Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH2 DNAH9 DNAH11

3.83e-0518743GO:0008569
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC6A7 SLC12A9 SLC17A1 SLC34A2 SLC13A2

8.02e-05119745GO:0015294
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH2 DNAH9 DNAH11

1.50e-0428743GO:0051959
GeneOntologyMolecularFunctionalpha-ketoglutarate transmembrane transporter activity

SLC22A6 SLC13A2

2.01e-046742GO:0015139
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC6A7 SLC17A1 SLC34A2 SLC13A2

2.33e-0481744GO:0015370
GeneOntologyMolecularFunctionsymporter activity

SLC6A7 SLC12A9 SLC17A1 SLC34A2 SLC13A2

2.38e-04150745GO:0015293
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH2 DNAH9 DNAH11

3.47e-0437743GO:0045505
GeneOntologyMolecularFunctionsphingomyelin phosphodiesterase activity

SMPD4 SMPD3

3.74e-048742GO:0004767
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC6A7 SLC22A6 ABCA3 CYBRD1 SLC12A9 SLC17A1 SLC34A2 SLC13A2

3.79e-04477748GO:0022804
GeneOntologyMolecularFunctionprotein-glutamine gamma-glutamyltransferase activity

TGM7 TGM5

4.80e-049742GO:0003810
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC6A7 SLC22A6 SLC12A9 SLC17A1 SLC34A2 SLC13A2

8.03e-04296746GO:0015291
GeneOntologyMolecularFunctionsodium:phosphate symporter activity

SLC17A1 SLC34A2

8.73e-0412742GO:0005436
GeneOntologyMolecularFunctionpalmitoyl hydrolase activity

PPT2 CPT1C

1.20e-0314742GO:0098599
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH2 DNAH9 DNAH11

2.24e-0370743GO:0003777
GeneOntologyMolecularFunctionimmunoglobulin receptor binding

IGHA1 IGHA2

2.72e-0321742GO:0034987
GeneOntologyMolecularFunctionhydrolase activity, acting on ester bonds

LPIN1 EPM2A PTPRA STS PPT2 CPT1C SMPD4 SMPD3 VARS1

2.90e-03807749GO:0016788
GeneOntologyMolecularFunctionphosphate transmembrane transporter activity

SLC17A1 SLC34A2

3.55e-0324742GO:0005315
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC22A6 SLC12A9 SLC17A1 SLC34A2

3.75e-03171744GO:0015103
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC6A7 SLC17A1 SLC34A2 SLC13A2

3.75e-03171744GO:0015081
GeneOntologyCellularComponentdimeric IgA immunoglobulin complex

IGHA1 IGHA2

3.80e-053752GO:0071750
GeneOntologyCellularComponentsecretory dimeric IgA immunoglobulin complex

IGHA1 IGHA2

3.80e-053752GO:0071752
GeneOntologyCellularComponentmonomeric IgA immunoglobulin complex

IGHA1 IGHA2

4.50e-049752GO:0071748
GeneOntologyCellularComponentpolymeric IgA immunoglobulin complex

IGHA1 IGHA2

5.61e-0410752GO:0071749
GeneOntologyCellularComponentIgA immunoglobulin complex, circulating

IGHA1 IGHA2

5.61e-0410752GO:0071746
GeneOntologyCellularComponentsecretory IgA immunoglobulin complex

IGHA1 IGHA2

5.61e-0410752GO:0071751
GeneOntologyCellularComponentdynein complex

DNAH2 DNAH9 DNAH11

9.65e-0454753GO:0030286
GeneOntologyCellularComponentIgA immunoglobulin complex

IGHA1 IGHA2

1.29e-0315752GO:0071745
GeneOntologyCellularComponent9+2 motile cilium

FSIP2 DNAH2 DNAH9 DNAH11 CFAP65

1.66e-03238755GO:0097729
GeneOntologyCellularComponentimmunoglobulin complex, circulating

IGHA1 IGHA2

1.67e-0317752GO:0042571
HumanPhenoDecreased fertility

FSIP2 PATL2 CYP11A1 NPAP1 DNAH2 SLC34A2 MEI1 ZP3 DNAH9 HYDIN DNAH11 CFAP65

9.27e-083802612HP:0000144
HumanPhenoInfertility

FSIP2 PATL2 NPAP1 DNAH2 MEI1 ZP3 DNAH9 HYDIN DNAH11 CFAP65

1.50e-063142610HP:0000789
HumanPhenoFemale infertility

PATL2 MEI1 ZP3 DNAH9 HYDIN DNAH11

2.97e-0684266HP:0008222
HumanPhenoDecreased fertility in females

PATL2 MEI1 ZP3 DNAH9 HYDIN DNAH11

1.04e-05104266HP:0000868
HumanPhenoAbnormal sperm motility

FSIP2 DNAH2 DNAH9 HYDIN DNAH11 CFAP65

1.85e-05115266HP:0012206
HumanPhenoAbnormal sperm physiology

FSIP2 DNAH2 DNAH9 HYDIN DNAH11 CFAP65

1.85e-05115266HP:0034809
HumanPhenoNeonatal respiratory distress

ABCA3 SMPD4 RUNX2 DNAH9 HYDIN DNAH11

9.66e-05154266HP:0002643
HumanPhenoPremature birth

ABCA3 DLL4 CYP11A1 SMPD4 DLL1 VARS1

2.08e-04177266HP:0001622
DomainDHC_N1

DNAH2 DNAH9 DNAH11

3.16e-068733PF08385
DomainDynein_heavy_dom-1

DNAH2 DNAH9 DNAH11

3.16e-068733IPR013594
DomainDynein_heavy_chain_D4_dom

DNAH2 DNAH9 DNAH11

2.02e-0514733IPR024317
DomainDynein_HC_stalk

DNAH2 DNAH9 DNAH11

2.02e-0514733IPR024743
DomainDynein_heavy_dom-2

DNAH2 DNAH9 DNAH11

2.02e-0514733IPR013602
DomainDHC_N2

DNAH2 DNAH9 DNAH11

2.02e-0514733PF08393
DomainMT

DNAH2 DNAH9 DNAH11

2.02e-0514733PF12777
DomainAAA_8

DNAH2 DNAH9 DNAH11

2.02e-0514733PF12780
DomainATPase_dyneun-rel_AAA

DNAH2 DNAH9 DNAH11

2.02e-0514733IPR011704
DomainAAA_5

DNAH2 DNAH9 DNAH11

2.02e-0514733PF07728
DomainDHC_fam

DNAH2 DNAH9 DNAH11

2.52e-0515733IPR026983
DomainDynein_heavy_dom

DNAH2 DNAH9 DNAH11

2.52e-0515733IPR004273
DomainDynein_heavy

DNAH2 DNAH9 DNAH11

2.52e-0515733PF03028
DomainDSL

DLL4 DLL1

9.00e-054732PF01414
DomainDSL

DLL4 DLL1

9.00e-054732SM00051
DomainDSL

DLL4 DLL1

1.50e-045732IPR001774
DomainDSL

DLL4 DLL1

1.50e-045732PS51051
DomainNotch_ligand_N

DLL4 DLL1

1.50e-045732IPR011651
DomainMNNL

DLL4 DLL1

1.50e-045732PF07657
DomainTransglut_N

TGM7 TGM5

5.33e-049732PF00868
DomainTRANSGLUTAMINASES

TGM7 TGM5

5.33e-049732PS00547
DomainTransglutaminase_N

TGM7 TGM5

5.33e-049732IPR001102
DomainTransglut_C

TGM7 TGM5

5.33e-049732PF00927
Domain-

TGM7 TGM5

5.33e-0497323.90.260.10
DomainGln_gamma-glutamylTfrase_euk

TGM7 TGM5

5.33e-049732IPR023608
DomainTransglutaminase_AS

TGM7 TGM5

5.33e-049732IPR013808
DomainPapD-like

HYDIN CFAP65

5.33e-049732IPR008962
DomainTransglutaminase_C

TGM7 TGM5

6.64e-0410732IPR008958
DomainTGc

TGM7 TGM5

8.10e-0411732SM00460
DomainTransglut_core

TGM7 TGM5

8.10e-0411732PF01841
DomainTransglutaminase-like

TGM7 TGM5

8.10e-0411732IPR002931
DomainC1-set

CD1E IGHA1 IGHA2

1.23e-0354733PF07654
DomainSEA

TMPRSS15 MUC16

1.33e-0314732SM00200
DomainIGc1

CD1E IGHA1 IGHA2

1.37e-0356733SM00407
DomainIg_C1-set

CD1E IGHA1 IGHA2

1.52e-0358733IPR003597
Domain-

TMPRSS15 MUC16

1.53e-03157323.30.70.960
DomainAAA+_ATPase

ABCA3 DNAH2 DNAH9 DNAH11

2.44e-03144734IPR003593
DomainAAA

ABCA3 DNAH2 DNAH9 DNAH11

2.44e-03144734SM00382
DomainSEA

TMPRSS15 MUC16

3.31e-0322732PF01390
DomainSEA

TMPRSS15 MUC16

3.61e-0323732PS50024
DomainSEA_dom

TMPRSS15 MUC16

3.61e-0323732IPR000082
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH2 DNAH9 DNAH11

1.54e-0427553M47755
PathwayREACTOME_SIGNALING_BY_NOTCH1_T_7_9_NOTCH1_M1580_K2555_TRANSLOCATION_MUTANT

DLL4 DLL1

3.10e-047552M27199
PathwayKEGG_MEDICUS_ENV_FACTOR_E2_TO_NUCLEAR_INITIATED_ESTROGEN_SIGNALING_PATHWAY

DLL4 DLL1

3.10e-047552M47805
PathwayKEGG_MEDICUS_REFERENCE_HYDROLYSIS_OF_SPHINGOMYELIN

SMPD4 SMPD3

4.12e-048552M47611
PathwayREACTOME_GLYCOSPHINGOLIPID_CATABOLISM

STS SMPD4 SMPD3

4.65e-0439553M48042
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_LIGAND_UBIQUITYLATION

DLL4 DLL1

5.29e-049552M47866
PathwayKEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT

DNAH2 DNAH9 DNAH11

6.21e-0443553M47669
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_SURFACTANT_METABOLISM

ABCA3 SLC34A2

6.59e-0410552M27573
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH2 DNAH9 DNAH11

7.10e-0445553M47670
Pubmed

Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries.

DNAH9 HYDIN DNAH11

4.17e-08477336140829
Pubmed

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

DNAH2 DNAH9 DNAH11

3.63e-07777331178125
Pubmed

Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein.

SMPD4 SMPD3

4.84e-06277216517606
Pubmed

The structure and function of human IgA.

IGHA1 IGHA2

4.84e-0627722241915
Pubmed

Neutral sphingomyelinase-3 mediates TNF-stimulated oxidant activity in skeletal muscle.

SMPD4 SMPD3

4.84e-06277225180167
Pubmed

Suppression of Th2 cell development by Notch ligands Delta1 and Delta4.

DLL4 DLL1

4.84e-06277218209061
Pubmed

Three-dimensional architecture of the thymus is required to maintain delta-like expression necessary for inducing T cell development.

DLL4 DLL1

4.84e-06277216393955
Pubmed

Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes.

DLL4 DLL1

4.84e-06277220548034
Pubmed

Isolation and characterization of the notch ligand delta4.

DLL4 DLL1

4.84e-06277211035934
Pubmed

The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts.

CYP11A1 RUNX2

4.84e-06277219342447
Pubmed

DLL1- and DLL4-Mediated Notch Signaling Is Essential for Adult Pancreatic Islet Homeostasis.

DLL4 DLL1

4.84e-06277232029480
Pubmed

Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo.

DLL4 DLL1

4.84e-06277215146182
Pubmed

Induction of T-cell development by Delta-like 4-expressing fibroblasts.

DLL4 DLL1

4.84e-06277223988616
Pubmed

In vivo and in absence of a thymus, the enforced expression of the Notch ligands delta-1 or delta-4 promotes T cell development with specific unique effects.

DLL4 DLL1

4.84e-06277215728481
Pubmed

Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice.

DLL4 DLL1

4.84e-06277231934853
Pubmed

Upregulation of smpd3 via BMP2 stimulation and Runx2.

SMPD3 RUNX2

4.84e-06277219250608
Pubmed

Dengue virus up-regulates expression of notch ligands Dll1 and Dll4 through interferon-β signalling pathway.

DLL4 DLL1

4.84e-06277225041739
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

DLL4 RUNX2 DLL1

8.31e-061877315689374
Pubmed

Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines.

DLL4 DLL1

1.45e-05377212684674
Pubmed

Ceramide triggers budding of exosome vesicles into multivesicular endosomes.

SMPD4 SMPD3

1.45e-05377218309083
Pubmed

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.

DLL4 DLL1

1.45e-05377221372153
Pubmed

Lack of Delta like 1 and 4 expressions in nude thymus anlages.

DLL4 DLL1

1.45e-05377216095582
Pubmed

DLL4 and Jagged1 are angiogenic targets of orphan nuclear receptor TR3/Nur77.

DLL4 NR4A1

1.45e-05377230930165
Pubmed

Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.

DLL4 DLL1

1.45e-05377223839946
Pubmed

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

DLL4 DLL1

2.89e-05477218824585
Pubmed

Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate.

DLL4 DLL1

2.89e-05477220602435
Pubmed

Characterization, quantification, and assessment of immune protection potential of secretory immunoglobulin A in colostrum samples from Saudi women.

IGHA1 IGHA2

2.89e-05477224145934
Pubmed

Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2.

DLL4 DLL1

2.89e-05477232820046
Pubmed

No evidence for a functional role of bi-directional Notch signaling during angiogenesis.

DLL4 DLL1

2.89e-05477223300864
Pubmed

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.

DLL4 DLL1

2.89e-05477228319044
Pubmed

Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin.

SMPD4 SMPD3

2.89e-05477219698806
Pubmed

Deregulation of RUNX2 by miR-320a deficiency impairs steroidogenesis in cumulus granulosa cells from polycystic ovary syndrome (PCOS) patients.

CYP11A1 RUNX2

2.89e-05477227965096
Pubmed

Defective immunoglobulin A (IgA) glycosylation and IgA deposits in patients with IgA nephropathy.

IGHA1 IGHA2

2.89e-05477223398317
Pubmed

Role of recycling, Mindbomb1 association, and exclusion from lipid rafts of δ-like 4 for effective Notch signaling to drive T cell development.

DLL4 DLL1

2.89e-05477223162128
Pubmed

Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.

DLL4 RUNX2 DLL1

3.66e-052977325535917
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

FSIP2 TDRD15 PTPRA CCDC168 MEX3C

3.70e-0516877530631154
Pubmed

Notch signaling regulates ovarian follicle formation and coordinates follicular growth.

DLL4 DLL1 ZP3

4.06e-053077324552588
Pubmed

Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.

DLL4 DLL1

4.82e-05577221726900
Pubmed

Neuralized-2: expression in human and rodents and interaction with Delta-like ligands.

DLL4 DLL1

4.82e-05577219723503
Pubmed

Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms.

DLL4 DLL1

4.82e-05577219110448
Pubmed

Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences.

IGHA1 IGHA2

4.82e-0557726421489
Pubmed

DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes.

DNAH9 DNAH11

4.82e-05577226909801
Pubmed

Human plasma-derived polymeric IgA and IgM antibodies associate with secretory component to yield biologically active secretory-like antibodies.

IGHA1 IGHA2

4.82e-05577223250751
Pubmed

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice.

DLL4 DLL1

4.82e-05577230181175
Pubmed

Redd1 is a novel marker of testis development but is not required for normal male reproduction.

DDIT4 CYP11A1

7.22e-05677222797524
Pubmed

Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells.

DLL4 DLL1

7.22e-05677219050235
Pubmed

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.

DNAH9 DNAH11

7.22e-05677233347437
Pubmed

Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches.

DLL4 DLL1

7.22e-05677219217325
Pubmed

Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing.

DLL4 DLL1

7.22e-05677235091558
Pubmed

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.

DLL4 DLL1

1.01e-04777226114479
Pubmed

Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion.

LPIN1 NR4A1

1.01e-04777229536159
Pubmed

Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.

DLL4 DLL1

1.01e-04777224025447
Pubmed

GCNT1-Mediated O-Glycosylation of the Sialomucin CD43 Is a Sensitive Indicator of Notch Signaling in Activated T Cells.

DLL4 DLL1

1.01e-04777232060138
Pubmed

Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z.

TGM7 TGM5

1.01e-04777211390390
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH2 DNAH11

1.01e-0477729256245
Pubmed

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.

DLL4 DLL1

1.01e-04777227576369
Pubmed

Bone morphogenic protein (BMP) signaling up-regulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt protein signaling pathway as a negative feedback mechanism.

SMPD3 RUNX2

1.01e-04777224505141
Pubmed

The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro.

DLL4 DLL1

1.01e-04777230289388
Pubmed

Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function.

CYP11A1 NR4A1

1.01e-04777214726490
Pubmed

Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells.

DLL4 DLL1

1.01e-04777221238454
Pubmed

HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A.

TGM7 TGM5

1.34e-0487727906657
Pubmed

Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro.

TGM7 TGM5

1.34e-0487727688299
Pubmed

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.

DLL4 DLL1

1.34e-04877224647000
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

DLL4 DLL1

1.72e-04977216245338
Pubmed

Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase.

SMPD4 SMPD3

1.72e-04977215509740
Pubmed

Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium.

DLL4 DLL1

1.72e-04977217605079
Pubmed

Dll4 and Notch signalling couples sprouting angiogenesis and artery formation.

DLL4 DLL1

1.72e-04977228714968
Pubmed

A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization.

SMPD3 RUNX2

1.72e-04977221788370
Pubmed

Expression of Phosphate Transporters during Dental Mineralization.

SLC17A1 SLC34A2

1.72e-04977228892649
Pubmed

Monitoring Notch1 activity in development: evidence for a feedback regulatory loop.

DLL4 DLL1

1.72e-04977217685488
Pubmed

Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation.

DLL4 DLL1

1.72e-04977220727173
Pubmed

Notch signaling is essential for vascular morphogenesis in mice.

DLL4 DLL1

1.72e-04977210837027
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

DLL4 DLL1

2.15e-041077223665443
Pubmed

Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle.

DLL4 DLL1

2.15e-041077224015274
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

DLL4 DLL1

3.15e-041277215465494
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

DLL4 DLL1

3.71e-041377211578869
Pubmed

Notch signaling is required for the maintenance of enteric neural crest progenitors.

DLL4 DLL1

3.71e-041377218832397
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH2 DNAH11

4.33e-04147729373155
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

DLL4 DLL1

4.33e-041477214757642
Pubmed

Structure and function of immunoglobulins.

IGHA1 IGHA2

4.99e-041577220176268
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

DLL4 DLL1

4.99e-041577212971992
Pubmed

Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos.

DLL1 DNAH11

5.69e-041677211900971
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

DLL4 DLL1

5.69e-041677212617809
Pubmed

A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs.

DLL4 DLL1

5.69e-041677235577801
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

DLL4 DLL1

5.69e-041677217273555
Pubmed

Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments.

DLL4 DLL1

5.69e-041677222464328
Pubmed

Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys.

SLC17A1 SLC34A2

5.69e-041677219679677
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

DLL4 DLL1

6.44e-041777218694942
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

DLL4 DLL1

6.44e-041777215821257
Pubmed

Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking.

DLL4 DLL1

6.44e-041777239315665
Pubmed

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

DLL4 DLL1

6.44e-041777223362346
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

DLL4 DLL1

7.23e-041877218093989
Pubmed

Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches.

DLL4 DLL1

8.07e-041977218505817
Pubmed

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.

SLC17A1 CYP11A1

8.07e-04197727628695
Pubmed

RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.

DLL4 DLL1

8.07e-041977220335360
Pubmed

Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.

DLL4 DLL1

8.07e-041977216518823
Pubmed

Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves.

DLL4 DLL1

8.07e-041977225691540
Pubmed

A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development.

DLL4 DLL1

8.96e-042077212588999
Pubmed

Mesenchymal cells are required for functional development of thymic epithelial cells.

DLL4 DLL1

9.89e-042177217625108
Pubmed

Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation.

DLL4 DLL1

9.89e-042177231631837
Cytoband15q15.2

TGM7 TGM5

3.28e-041677215q15.2
GeneFamilyDyneins, axonemal

DNAH2 DNAH9 DNAH11

1.57e-0517533536
GeneFamilyTransglutaminases

TGM7 TGM5

3.00e-049532773
GeneFamilySolute carriers

SLC6A7 SLC22A6 SLC12A9 SLC17A1 SLC34A2 SLC13A2

1.01e-03395536752
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.49e-091917787b5da29109aa28768c67653a1bc0f385c2d2269b
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.49e-091917789f19098f260d5542aa8ba7eb6f91b44d0db6e0a4
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.49e-09191778fa9f8b50bfc7911c858bc2f9dcd204873d97ac61
ToppCellControl-Epithelial-Ciliated_cells|Control / Condition, Lineage and Cell class

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.49e-09191778ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.49e-09191778b4e335e798c9617356b8e24412f9270c42dce656
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.49e-09191778c4b223b33c020a064f576711a3d700eb60a2d737
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.49e-091917785129f778a9283bfac4ff322c21c5ca71da4b7174
ToppCellBAL-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.49e-09191778df8a1a6e78aa0cb941b94cb676bd6891d79f3687
ToppCellControl-Epithelial|Control / Disease group,lineage and cell class (2021.01.30)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.49e-09191778b78547dae8328244a47c83346447bdd787efbcae
ToppCellBAL-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.49e-09191778c50d6a1a6209ed4157f7c00fc24d4ecb43790f44
ToppCellControl-Epithelial-Ciliated|Control / Disease group,lineage and cell class (2021.01.30)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.49e-09191778cdc08e95a0c8f5c7a8d01b6bbaafdb54ef2f0d12
ToppCellControl-Epithelial|Control / Condition, Lineage and Cell class

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.49e-091917786228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCell5'-Adult-Distal_Rectal-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LPIN1 DDIT4 IGHA1 IGHA2 RUNX2 MEI1 ZP3

2.11e-0817377762abaaaf48cabd1423f17fb27c33b75ea88867f4
ToppCell5'-Adult-Distal_Rectal-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LPIN1 DDIT4 IGHA1 IGHA2 RUNX2 MEI1 ZP3

2.11e-0817377709cd878c33534bd476d6a4880f5582076189da8c
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

DNAH2 MUC16 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

3.35e-0818577718a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH2 MUC16 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

4.16e-08191777e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH2 MUC16 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

4.16e-081917779d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH2 MUC16 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

4.16e-081917771c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellASK454|World / Donor, Lineage and Cell class of Lung cells from Dropseq

DDIT4 ABCA3 IGHA1 IGHA2 SLC34A2 CSKMT NR4A1

4.32e-081927776b047b445a0df0ecdd6d7baf388a0d966a93b3a2
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DNAH2 MUC16 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

4.63e-08194777756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCellCOVID-19-Epithelial-Ciliated_cells|COVID-19 / Condition, Lineage and Cell class

DNAH2 MUC16 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

4.63e-0819477743be5fbd51dd58839cb03ca3ddd05a458e1ddb74
ToppCellCOVID-19-Epithelial|COVID-19 / Condition, Lineage and Cell class

DNAH2 MUC16 SLC34A2 DNAH9 HYDIN DNAH11 CFAP65

5.15e-0819777718fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCellBAL-Mild-Epithelial-Epithelial|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11

5.51e-081997771ee4010d8557564e25e8ee00b914c2dfd9037838
ToppCellBAL-Mild-Epithelial-Epithelial|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11

5.51e-081997771df69c0cb5f759f6a2152521842506a75bb95cae
ToppCellMild-Epithelial-Epithelial-|Mild / Condition, Lineage, Cell class and cell subclass

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11

5.51e-0819977781115bbd2c10bfdd38376d2075f03a59c31870d2
ToppCellBAL-Mild-Epithelial|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11

5.51e-0819977774087b4b5e567310fc4ac58fb267ff651a180680
ToppCellBAL-Mild-Epithelial|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11

5.51e-0819977700b5ce099c50a5e1786ce2b3a06ee0931a8205a4
ToppCellMild-Epithelial|Mild / Condition, Lineage, Cell class and cell subclass

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11

5.51e-08199777ec5fff80e2a8a94fbaf1fdcc6d45c8d7c6252e18
ToppCellMild-Epithelial-Epithelial|Mild / Condition, Lineage, Cell class and cell subclass

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11

5.51e-0819977791308b255783ad4029e5575028c18d7550832c51
ToppCellMild_COVID-19-Epithelial|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

DNAH2 MUC16 SLC34A2 C11orf16 DNAH9 HYDIN DNAH11

5.51e-0819977772689bda7476930887ae007682fcab27f956f050
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 MUC16 DNAH9 HYDIN DNAH11 CFAP65

4.89e-0716977614aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

5.60e-07173776c3762655caa79ac4879876f470d32578a3c93b01
ToppCelldroplet-Fat-Gat-18m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C11orf16 ZP3 DNAH9 HYDIN DNAH11 CFAP65

5.60e-07173776f3f67531f72d6d52e19c7f1f2db1ab4026fb70da
ToppCelldroplet-Fat-Gat-18m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C11orf16 ZP3 DNAH9 HYDIN DNAH11 CFAP65

5.60e-07173776a40a52d8041d45dc3bef74fe55945ae07aa018d6
ToppCelldroplet-Fat-Gat-18m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C11orf16 ZP3 DNAH9 HYDIN DNAH11 CFAP65

5.60e-07173776f0b4dd1cf41d6ee6abb0e1968b8b39f4fabebcb5
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

7.54e-071827767ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

7.54e-07182776fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

8.03e-071847765daff849625f2f41d56615569c0ed59cd733b34c
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH2 C11orf16 DNAH9 HYDIN MYBL2 CFAP65

8.29e-0718577605bc89a566b0db90ae06506e067190a4739a0974
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

8.29e-071857765e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellCiliated_cells-B-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

DNAH2 MUC16 C11orf16 DNAH9 HYDIN DNAH11

8.29e-07185776f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

8.29e-0718577630f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

8.56e-0718677676033438426d8f9c72cd6691a7baf92104c9f03d
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

8.56e-0718677685787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

9.11e-0718877661a459f3fe57e5728efc72637ff2edc2d343492b
ToppCell21-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

9.11e-07188776803bf76a85b3033d2a04b08dd2c03ce9c15529ba
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

9.11e-0718877634b11f72ca73153d02edcd09b38983ad1a504659
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

9.11e-071887762b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCellCOVID-19-lung-Ciliated|COVID-19 / Disease (COVID-19 only), tissue and cell type

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

9.39e-07189776a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

9.39e-0718977668a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

9.39e-07189776b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

9.39e-0718977627329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

9.99e-071917762a8e6d560907e71e9f6e190ca0667da804e25641
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

9.99e-0719177646c9d4d10c66c0fae1fa351924091b69ea2f38d4
ToppCellMild_COVID-19-Epithelial-Ciliated|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

9.99e-07191776995e76bbf07674d95b8ef09e078cf6410af27a09
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

9.99e-07191776a37f20172b85566b9039254a89680e37fd503fd5
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

9.99e-071917762d36e08c5629cf73b6dd02cd173cafb52e8a3a7d
ToppCellwk_15-18-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DNAH2 MUC16 DNAH9 HYDIN DNAH11 CFAP65

9.99e-07191776e81cd65dbf0ef1c2ab7088f73ce605d456dd3a7a
ToppCellnormal_Lung-Epithelial_cells-Ciliated|normal_Lung / Location, Cell class and cell subclass

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.03e-06192776097a13121820ab4e5cd2365600efccf5ea4ce8c3
ToppCellCiliated-cil-3|World / Class top

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.03e-061927764989ebb8812b8af1870599acd932849122c05a29
ToppCell15-Trachea-Epithelial-Intermediate_ciliated|Trachea / Age, Tissue, Lineage and Cell class

DNAH2 MUC16 C11orf16 DNAH9 HYDIN DNAH11

1.03e-061927769cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCellCOPD-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

MUC16 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.03e-06192776eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCellIPF-Epithelial-Ciliated|IPF / Disease state, Lineage and Cell class

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.03e-06192776354adc1354bf596fbc60dd45c0169688e6f45165
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.06e-06193776ea345d34440b25f65358a53dc72831998d1c3620
ToppCell15-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.06e-06193776aa3acc7571405169efb656d214f3a8cbf988362e
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.09e-061947761ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCellwk_15-18-Epithelial-Proximal_epithelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.09e-06194776b0477583301dc6d9767b667bd2f8f94fbfaa6f81
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 MUC16 C11orf16 DNAH9 HYDIN DNAH11

1.09e-061947764a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellcellseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.13e-06195776d8bf15aa7cdbc5f29b58e1e6cff76c257f0ea12e
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.13e-06195776cfcf554b436083179dea1d6fd6e3a800ea2430fe
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.13e-061957763486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellmoderate-Epithelial-Ciliated|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.13e-06195776e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCellcellseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.13e-06195776e7f069f557a59ee7b502ff82ad4c9f47fa619ba8
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.16e-06196776a37ba02446eef5d1fab703204583f6550a8ec3e1
ToppCellCOVID-19-Epithelial-Ciliated_cells|Epithelial / Condition, Lineage and Cell class

DNAH2 MUC16 DNAH9 HYDIN DNAH11 CFAP65

1.16e-06196776de7aa31354b019d7321a8ef965d59ce2e8b89276
ToppCellcritical-Epithelial-Ciliated|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.16e-0619677627b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.16e-06196776a156840330630e518bc85633dded6f2c3ead3b30
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.16e-06196776009e83c7251cf300be78b263634d233a8d972a68
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.16e-06196776686a5a0ddb00929842c1c98445c59edfcc9a8a04
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.16e-0619677667aefc480714e4b8c9ae53c036efdc07ec6f94af
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.16e-06196776ca56311edc6788e032e7635fa69b1e07035202b5
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.16e-0619677689ea4d2086e1c769c5a87f1471a6cd4acabcfe33
ToppCellSevere_COVID-19-Epithelial-Ciliated|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.16e-061967761cdef976a754c90d18b6149d367bd64e6e99b0a9
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.16e-06196776d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.16e-0619677669f5081e06d84ec1d9695762df801a9d0df1984b
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 MUC16 C11orf16 DNAH9 HYDIN DNAH11

1.20e-0619777691637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 MUC16 C11orf16 DNAH9 HYDIN DNAH11

1.20e-0619777622c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NPAP1 DNAH2 DNAH9 HYDIN DNAH11 CFAP65

1.20e-0619777674a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 MUC16 C11orf16 DNAH9 HYDIN DNAH11

1.20e-061977763bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 MUC16 C11orf16 DNAH9 HYDIN DNAH11

1.20e-0619777687db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCelldistal-3-Epithelial-Proximal_Ciliated|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DNAH2 MUC16 C11orf16 DNAH9 HYDIN CFAP65

1.20e-0619777615b4d1203943ce90a7083178d4a4284d9b323071
ToppCellwk_20-22-Epithelial-Proximal_epithelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.23e-0619877616c54b884500066ade05a406915f9569ca8abdfc
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.23e-06198776ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCellmedial-Epithelial-Ciliated-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.27e-06199776526002f16bbf61cf086278d45a401cc0b0b757a8
ToppCelldistal-Epithelial-Ciliated-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.27e-061997762de1fe124737a6cca4b3805ab3056f9d9d7c16c7
ToppCellmedial-Epithelial-Ciliated|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.27e-06199776a2daa42b100c422dc8c04fb7d2ebf54293eef574
ToppCelldistal-Epithelial-Ciliated|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.27e-0619977618ca031cfe702afb9bf94e03c0f3680c38e7599e
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DNAH2 MUC16 C11orf16 DNAH9 HYDIN CFAP65

1.27e-061997762498237b9e895ca4826a3378d9d40989968df72b
ToppCellmedial-2-Epithelial-Ciliated|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DNAH2 C11orf16 DNAH9 HYDIN DNAH11 CFAP65

1.27e-06199776c02f04a5aa79ee0cf427f6e94b93ceab38ebbcd7
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DNAH2 MUC16 C11orf16 DNAH9 HYDIN CFAP65

1.27e-06199776542ec45c931b40738df1f3777b00c83be33a514a
Drugcelecoxib; Up 200; 10uM; MCF7; HT_HG-U133A_EA

LPIN1 DDIT4 STS ABI3BP AP5Z1 ZNF589 NR4A1 TGM5

2.26e-07189768922_UP
Drug2-bromopalmitate

PPRC1 CPT1C SLC34A2 NR4A1 ZDHHC3

2.76e-0666765CID000082145
DrugD-8 (pharmaceutical)

STS RUNX2 DLL1

2.96e-069763CID000107261
DrugLisuride (S)(-) [18016-80-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A

TRIM33 DDIT4 CD1E PTPRA STS ZNF589 SLC34A2

4.03e-061957671545_UP
Drugnordihydroguaiaretic acid; Up 200; 1uM; MCF7; HT_HG-U133A

LPIN1 EPM2A PTPRA AP5Z1 SQLE ZNF589 NR4A1

4.17e-061967676942_UP
Drug17-hydroxypregnenolone

STS DLL4 CYP11A1 NR4A1

1.68e-0546764CID000091451
Drugcalmidazolium chloride; Up 200; 5uM; MCF7; HG-U133A

LPIN1 DDIT4 AP5Z1 ZNF589 NR4A1 RUNX2

1.90e-05165766486_UP
Drugmangrove

LPIN1 EPM2A PIK3C2G PPRC1 CPT1C SQLE NR4A1 DLL1 ADCY8

2.55e-05468769CID000000965
DrugSyrosingopine [84-36-6]; Up 200; 6uM; MCF7; HT_HG-U133A

LPIN1 DDIT4 JADE2 AP5Z1 SQLE NR4A1

2.92e-051787662753_UP
DrugMonensin sodium salt [22373-78-0]; Up 200; 5.8uM; PC3; HT_HG-U133A

LPIN1 DDIT4 TMPRSS15 SQLE ZNF589 NR4A1

3.41e-051837663704_UP
DrugMan5GlcNAc2

TMPRSS15 EPM2A MAN2B2 ZP3

3.44e-0555764CID003081562
Drugfurosemide

SLC22A6 SLC12A9 SLC17A1 PPRC1 SLC34A2 SLC13A2 ADCY8

3.48e-05272767CID000003440
DrugNifedipine [21829-25-4]; Down 200; 11.6uM; HL60; HT_HG-U133A

LPIN1 ZBTB44 EPM2A PTPRA ZNF589 NR4A1

4.72e-051947661856_DN
DrugKetoconazole [65277-42-1]; Up 200; 7.6uM; PC3; HT_HG-U133A

TRIM33 DDIT4 TMPRSS15 STS SQLE TGM5

4.72e-051947664624_UP
DrugMethotrimeprazine maleat salt [7104-38-3]; Up 200; 9uM; MCF7; HT_HG-U133A

LPIN1 DDIT4 SQLE ZNF589 SLC34A2 C11orf16

4.86e-051957664723_UP
DrugDroperidol [548-73-2]; Down 200; 10.6uM; PC3; HT_HG-U133A

ZBTB44 EPM2A ABCA3 PTPRA STS NR4A1

5.00e-051967664629_DN
Drugipsapirone

SLC22A6 HTR1B PPRC1 ADCY8

5.18e-0561764CID000056971
DrugDOCP

DYM PPRC1 DLL1

5.26e-0522763CID000013126
DrugAcyclovir [59277-89-3]; Up 200; 17.8uM; HL60; HG-U133A

ZBTB44 PTPRA TBC1D4 NET1 AP5Z1 MEX3C

5.59e-052007662044_UP
DrugN-n-propylnorapomorphine

HTR1B PPRC1 ADCY8

7.80e-0525763CID000030137
DiseasePrimary Ciliary Dyskinesia

DNAH9 HYDIN DNAH11

2.45e-0447763C4551720
DiseaseInherited oocyte maturation defect

PATL2 ZP3

7.67e-0416762cv:CN238505
Diseasephosphatidylcholine 40:6 measurement

PTPRA DNAH9

8.68e-0417762EFO_0010389
Diseaseischemia (biomarker_via_orthology)

HTR1B DLL4

9.75e-0418762DOID:326 (biomarker_via_orthology)
Diseaseeye color

SLC12A9 MUC16 ADCY8

1.64e-0390763EFO_0003949
Diseaseomega-6 polyunsaturated fatty acid measurement

TDRD15 PPT2 DNAJB8 DNAH11

1.70e-03197764EFO_0005680
Diseaseintelligence, response to cranial radiation therapy

RUNX2 ADCY8

2.37e-0328762EFO_0004337, EFO_0010950

Protein segments in the cluster

PeptideGeneStartEntry
ATFTEGSWSPELPFD

ADCY8

616

P40145
FNSPTPPWLGFVSSF

EPM2A

301

B3EWF7
FSISISLPPFFWRQA

HTR1B

176

P28222
LSGFSVFLLPWAPLS

CYBRD1

136

Q53TN4
NEDFHPSWSPSSLPF

CSRNP2

496

Q9H175
NPLQLPFNFTWPGTF

DLL4

101

Q9NR61
PFNFTWPGTFSLIIE

DLL4

106

Q9NR61
PAVVWLSGFFNPQSF

DNAH11

4371

Q96DT5
TEGWHTTSLFPLFPN

ABCA3

176

Q99758
FKFLAWNSPPLTSEF

AP5Z1

436

O43299
TQSFWLFRVSPTTFP

ATP8B3

1161

O60423
GLDPFSFEFWDSPFN

DNAJB8

106

Q8NHS0
NTFFVPTAPKWDSTG

PIK3C2G

61

O75747
LSPWDGSFGHFSPSQ

NR4A1

151

P22736
SFTFLTPGPNWDFTL

NET1

51

Q7Z628
PTWGIPQSTLTFEFS

MUC16

2881

Q8WXI7
VGDLPTFFTWEFSSP

CFAP65

271

Q6ZU64
TFFTWEFSSPFQMLP

CFAP65

276

Q6ZU64
GPFELWEPNTTFSST

TMPRSS15

526

P98073
PLFSGDWSSTFFSFL

FSIP2

5396

Q5CZC0
TSFPIDGTFFNSWLA

JADE2

521

Q9NQC1
AQPRLGTVPTFDWFF

CSKMT

41

A8MUP2
TFSNFTFWREPLPPF

LPIN1

866

Q14693
GFSDWPSLQPVLFAL

OR2I1P

16

Q8NGU4
PFAFLGFLFWSPLQS

SMPD3

76

Q9NY59
SFLSPWPPAVTDASF

SMPD4

551

Q9NXE4
PSFNFLYWSLHQTTP

MEI1

956

Q5TIA1
PVATVQTTWLFSFPF

OR10A2

141

Q9H208
PDDGVITPWQSSFFG

PPT2

226

Q9UMR5
FWPTFPSTSSPAQHF

PATL2

111

C9JE40
FWNDFLTGVFPASPL

CPT1C

46

Q8TCG5
DFLSFQGISWEPSPG

CD1E

146

P15812
FQFTPFHLGITESSW

HYDIN

4046

Q4G0P3
PFWNQLLSFSFPAPT

DYM

31

Q7RTS9
WPKIQGLFSSANSPF

DDIT4

186

Q9NX09
PFGFTWPGTFSLIIE

DLL1

111

O00548
FSDILSGLPFIGFFW

SQLE

66

Q14534
FFPQEPLSVTWSESG

IGHA1

31

P01876
PTFFFDPENFDPTRW

CYP11A1

426

P05108
DFLPYSTEPFQAWTG

MAN2B2

346

Q9Y2E5
FFPQEPLSVTWSESG

IGHA2

31

P01877
PSTVWLTGFFNPQSF

DNAH9

4341

Q9NYC9
LFPPWTFQFQSGDLE

CCDC168

5921

Q8NDH2
LISPAWFQTPTFSFG

LHFPL7

21

Q6ICI0
GSFLNWFSFFPLLGR

DNAJC22

216

Q8N4W6
IFWLSGFTFPTGFLT

DNAH2

4276

Q9P225
NSWGIPLFSLHSFPS

SLC13A2

556

Q13183
FTSPQWGLPFLNGTE

SLC22A6

81

Q4U2R8
SWDFSPPSFLETSSP

PPRC1

206

Q5VV67
TQFHFTSWPDFGVPF

PTPRA

401

P18433
LGWPTVNFVATFSSP

ARHGAP20

156

Q9P2F6
NFFWDPSTSRRFSPP

RUNX2

16

Q13950
TSASPPTFFWANASG

RXFP4

6

Q8TDU9
FSSGLFPLSILGWPN

VARS1

791

P26640
FWGTILFTTCFFTPG

TAAR3P

196

Q9P1P4
PTLLSFPSGDWICTF

TRIM33

916

Q9UPN9
SVPFSFDPNTAAGWL

TRIM35

301

Q9UPQ4
FKNPFTLSVGPESSW

TDRD15

731

B5MCY1
VKTLPFSPSQFLNFW

MYBL2

446

P10244
SLPVWAISTGSFTFF

SLC17A1

261

Q14916
DFSPTSPFSTGNFWF

MEX3C

466

Q5U5Q3
SPFSTGNFWFGDTLP

MEX3C

471

Q5U5Q3
TSIWKAFFFTPNFNP

STS

461

P08842
PSTTSVFPFGQAAWD

NPAP1

1046

Q9NZP6
TMLPLSPFWSFLFFF

SLC6A7

376

Q99884
FWEDGSVPSPSLFST

CLEC12B

216

Q2HXU8
PAFSGLTWAPFLFLF

RPP38-DT

121

Q8N326
SFTYPFALQAPWLTG

C11orf16

36

Q9NQ32
KTINTDFPFPFAWLT

SLC34A2

401

O95436
PWPSQSANFPEFSFD

UHRF1BP1L

1406

A0JNW5
FSLGWASPFATPDQG

ZDHHC3

276

Q9NYG2
NDPFFPLSFLVNSWL

TMEM181

361

Q9P2C4
WASAPNFRPTFSLFS

SLC12A9

441

Q9BXP2
PVDSSLAFPWTFPFG

ZBTB44

221

Q8NCP5
DGSPLSPFWQDTAFI

TGM5

551

O43548
PWFLTLFASQFSLGF

TBC1D4

1086

O60343
GFSSLFQRPPISSWG

ZNF589

166

Q86UQ0
TPSSVFLSWGFLINP

ABI3BP

126

Q7Z7G0
TYPLGTFILLFNPWS

TGM7

131

Q96PF1
SFSKPSNSWFPVEGS

ZP3

301

P21754
NFFPENPAFSAWGTS

YTHDF1

121

Q9BYJ9
SSWLSAAFPGPAFDF

nan

206

Q6ZQT7
QDPGLPFLFWFSVAS

KIAA2013

586

Q8IYS2