Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	MYT1L ZNF8 ZNF771 SCRT2 ZNF135 ZBTB38 ZNF547 ZNF473 ZNF484 ZNF607 ZBTB25 ZNF875 ZNF587 ZNF436 ZNF343 ZNF202 ZNF205 ZNF552 ZNF578 ZBTB41 ZNF217 PPARD ZNF229 PPARG ZKSCAN4 ZNF417 SNAI3 CASZ1 ZNF546 ZNF646 ZNF707	1.34e-16	1412	76	31	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	MYT1L ZNF8 ZNF771 SCRT2 ZNF135 ZBTB38 ZNF547 ZNF473 ZNF484 ZNF607 ZBTB25 ZNF875 ZNF587 ZNF436 ZNF343 ZNF202 ZNF205 ZNF552 ZNF578 ZBTB41 ZNF217 PPARD ZNF229 PPARG ZKSCAN4 ZNF417 SNAI3 CASZ1 ZNF546 ZNF646 ZNF707	3.34e-16	1459	76	31	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	MYT1L ZNF8 ZNF771 SCRT2 ZNF135 ZBTB38 ZNF547 ZNF473 ZNF484 ZNF607 ZBTB25 ZNF587 ZNF202 ZNF205 ZNF552 ZNF578 ZBTB41 ZNF217 PPARD ZNF229 PPARG ZKSCAN4 ZNF417 SNAI3 ZNF546 ZNF646 ZNF707	3.16e-14	1244	76	27	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	MYT1L ZNF8 ZNF771 SCRT2 ZNF135 ZBTB38 ZNF547 ZNF473 ZNF484 ZNF607 ZBTB25 ZNF587 ZNF202 ZNF205 ZNF552 ZNF578 ZBTB41 ZNF217 PPARD ZNF229 PPARG ZKSCAN4 ZNF417 SNAI3 ZNF546 ZNF646 ZNF707	5.31e-14	1271	76	27	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	MYT1L SCRT2 ZBTB25 ZNF202 ZNF205 ZNF217 PPARD PPARG ZKSCAN4 SNAI3	3.64e-07	320	76	10	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	MYT1L SCRT2 ZBTB25 ZNF202 ZNF205 ZNF217 PPARD PPARG ZKSCAN4 SNAI3	4.31e-07	326	76	10	GO:0001217
GeneOntologyMolecularFunction	zinc ion binding	MYT1L ZNF8 ZCCHC12 LIN28B ZNF875 ZNF343 ZNF205 EEA1 PPARD PPARG LIN28A BRAP	1.29e-04	891	76	12	GO:0008270
GeneOntologyMolecularFunction	transition metal ion binding	MYT1L ZNF8 ZCCHC12 LIN28B ZNF875 AOC3 ZNF343 ZNF205 EEA1 PPARD PPARG SNAI3 LIN28A BRAP	1.39e-04	1189	76	14	GO:0046914
GeneOntologyMolecularFunction	prostaglandin receptor activity	PPARD PPARG	7.69e-04	11	76	2	GO:0004955
GeneOntologyMolecularFunction	prostanoid receptor activity	PPARD PPARG	9.21e-04	12	76	2	GO:0004954
GeneOntologyMolecularFunction	icosanoid receptor activity	PPARD PPARG	1.66e-03	16	76	2	GO:0004953
GeneOntologyMolecularFunction	calcium ion binding	SCUBE1 MEGF8 EFEMP2 SLIT3 AOC3 FSTL4 CUBN VWCE F7	2.11e-03	749	76	9	GO:0005509
Domain	ZINC_FINGER_C2H2_2	ZNF8 ZNF771 SCRT2 ZNF135 ZBTB38 ZNF547 GTF3A ZNF473 ZNF484 ZNF607 ZNF592 ZBTB25 ZNF875 ZNF587 ZNF436 ZNF343 ZNF511 ZNF202 ZNF205 ZNF552 ZNF578 ZNF233 ZBTB41 ZNF217 EEA1 ZNF229 ZKSCAN4 ZNF417 SNAI3 CASZ1 ZNF546 ZNF646 ZNF707	4.96e-26	775	75	33	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF8 ZNF771 SCRT2 ZNF135 ZBTB38 ZNF547 GTF3A ZNF473 ZNF484 ZNF607 ZNF592 ZBTB25 ZNF875 ZNF587 ZNF436 ZNF343 ZNF511 ZNF202 ZNF205 ZNF552 ZNF578 ZNF233 ZBTB41 ZNF217 EEA1 ZNF229 ZKSCAN4 ZNF417 SNAI3 CASZ1 ZNF546 ZNF646 ZNF707	5.39e-26	777	75	33	PS00028
Domain	Znf_C2H2-like	ZNF8 ZNF771 SCRT2 ZNF135 ZBTB38 ZNF547 GTF3A ZNF473 ZNF484 ZNF607 ZNF592 ZBTB25 ZNF875 ZNF587 ZNF436 ZNF343 ZNF511 ZNF202 ZNF205 ZNF552 ZNF578 ZNF233 ZBTB41 ZNF217 EEA1 ZNF229 ZKSCAN4 ZNF417 SNAI3 CASZ1 ZNF546 ZNF646 ZNF707	1.16e-25	796	75	33	IPR015880
Domain	Znf_C2H2	ZNF8 ZNF771 SCRT2 ZNF135 ZBTB38 ZNF547 GTF3A ZNF473 ZNF484 ZNF607 ZNF592 ZBTB25 ZNF875 ZNF587 ZNF436 ZNF343 ZNF511 ZNF202 ZNF205 ZNF552 ZNF578 ZNF233 ZBTB41 ZNF217 EEA1 ZNF229 ZKSCAN4 ZNF417 SNAI3 CASZ1 ZNF546 ZNF646 ZNF707	1.67e-25	805	75	33	IPR007087
Domain	ZnF_C2H2	ZNF8 ZNF771 SCRT2 ZNF135 ZBTB38 ZNF547 GTF3A ZNF473 ZNF484 ZNF607 ZNF592 ZBTB25 ZNF875 ZNF587 ZNF436 ZNF343 ZNF511 ZNF202 ZNF205 ZNF552 ZNF578 ZNF233 ZBTB41 ZNF217 EEA1 ZNF229 ZKSCAN4 ZNF417 SNAI3 CASZ1 ZNF546 ZNF646 ZNF707	1.87e-25	808	75	33	SM00355
Domain	zf-C2H2	ZNF8 ZNF771 SCRT2 ZNF135 ZBTB38 ZNF547 GTF3A ZNF473 ZNF484 ZNF607 ZNF592 ZNF875 ZNF587 ZNF436 ZNF343 ZNF511 ZNF202 ZNF205 ZNF552 ZNF578 ZNF233 ZBTB41 ZNF217 ZNF229 ZKSCAN4 ZNF417 SNAI3 CASZ1 ZNF546 ZNF646 ZNF707	5.66e-25	693	75	31	PF00096
Domain	-	ZNF8 ZNF771 SCRT2 ZNF135 ZBTB38 ZNF547 GTF3A ZNF473 ZNF484 ZNF607 ZBTB25 ZNF875 ZNF587 ZNF436 ZNF343 ZNF511 ZNF202 ZNF205 ZNF552 ZNF578 ZNF233 ZBTB41 ZNF217 ZNF229 ZKSCAN4 ZNF417 SNAI3 ZNF546 ZNF646 ZNF707	5.86e-24	679	75	30	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF8 ZNF771 SCRT2 ZNF135 ZBTB38 ZNF547 GTF3A ZNF473 ZNF484 ZNF607 ZBTB25 ZNF875 ZNF587 ZNF436 ZNF343 ZNF511 ZNF202 ZNF205 ZNF552 ZNF578 ZNF233 ZBTB41 ZNF217 ZNF229 ZKSCAN4 ZNF417 SNAI3 ZNF546 ZNF646 ZNF707	1.10e-23	694	75	30	IPR013087
Domain	KRAB	ZNF8 ZNF135 ZNF547 ZNF473 ZNF484 ZNF607 ZNF875 ZNF587 ZNF436 ZNF343 ZNF202 ZNF205 ZNF552 ZNF578 ZNF233 ZNF229 ZKSCAN4 ZNF417 ZNF546 ZNF707	8.13e-18	358	75	20	PS50805
Domain	KRAB	ZNF8 ZNF135 ZNF547 ZNF473 ZNF484 ZNF607 ZNF875 ZNF587 ZNF436 ZNF343 ZNF202 ZNF205 ZNF552 ZNF578 ZNF233 ZNF229 ZKSCAN4 ZNF417 ZNF546 ZNF707	8.13e-18	358	75	20	PF01352
Domain	KRAB	ZNF8 ZNF135 ZNF547 ZNF473 ZNF484 ZNF607 ZNF875 ZNF587 ZNF436 ZNF343 ZNF202 ZNF205 ZNF552 ZNF578 ZNF233 ZNF229 ZKSCAN4 ZNF417 ZNF546 ZNF707	1.47e-17	369	75	20	SM00349
Domain	KRAB	ZNF8 ZNF135 ZNF547 ZNF473 ZNF484 ZNF607 ZNF875 ZNF587 ZNF436 ZNF343 ZNF202 ZNF205 ZNF552 ZNF578 ZNF233 ZNF229 ZKSCAN4 ZNF417 ZNF546 ZNF707	1.55e-17	370	75	20	IPR001909
Domain	zf-C2H2_6	ZNF8 ZNF771 SCRT2 ZNF135 ZNF473 ZNF607 ZNF587 ZNF578 ZBTB41 ZNF229 ZKSCAN4 ZNF417 ZNF546 ZNF646	2.41e-11	314	75	14	PF13912
Domain	EGF_Ca-bd_CS	SCUBE1 MEGF8 EFEMP2 SLIT3 CUBN VWCE F7	1.22e-07	97	75	7	IPR018097
Domain	EGF_CA	SCUBE1 MEGF8 EFEMP2 SLIT3 CUBN VWCE F7	1.40e-07	99	75	7	PS01187
Domain	EGF-type_Asp/Asn_hydroxyl_site	SCUBE1 MEGF8 EFEMP2 SLIT3 CUBN VWCE F7	2.24e-07	106	75	7	IPR000152
Domain	EGF_CA	SCUBE1 MEGF8 EFEMP2 SLIT3 CUBN VWCE F7	5.86e-07	122	75	7	SM00179
Domain	EGF-like_Ca-bd_dom	SCUBE1 MEGF8 EFEMP2 SLIT3 CUBN VWCE F7	6.55e-07	124	75	7	IPR001881
Domain	ASX_HYDROXYL	SCUBE1 MEGF8 EFEMP2 CUBN VWCE F7	3.02e-06	100	75	6	PS00010
Domain	EGF	SCUBE1 MEGF8 EFEMP2 SLIT3 ZNF578 CUBN VWCE F7	4.55e-06	235	75	8	SM00181
Domain	EGF_3	SCUBE1 MEGF8 CUBN	1.33e-05	12	75	3	PF12947
Domain	EGF_dom	SCUBE1 MEGF8 CUBN	1.33e-05	12	75	3	IPR024731
Domain	EGF_CA	SCUBE1 MEGF8 EFEMP2 CUBN VWCE	2.47e-05	86	75	5	PF07645
Domain	Growth_fac_rcpt_	SCUBE1 MEGF8 EFEMP2 SLIT3 CUBN VWCE	3.86e-05	156	75	6	IPR009030
Domain	EGF_3	SCUBE1 MEGF8 EFEMP2 SLIT3 CUBN VWCE F7	4.38e-05	235	75	7	PS50026
Domain	1Cnucl_rcpt	PPARD PPARG	4.76e-05	3	75	2	IPR003074
Domain	EGF-like_dom	SCUBE1 MEGF8 EFEMP2 SLIT3 CUBN VWCE F7	6.31e-05	249	75	7	IPR000742
Domain	EGF_1	SCUBE1 MEGF8 EFEMP2 SLIT3 CUBN VWCE F7	7.33e-05	255	75	7	PS00022
Domain	EGF-like_CS	SCUBE1 MEGF8 EFEMP2 SLIT3 CUBN VWCE F7	8.48e-05	261	75	7	IPR013032
Domain	EGF_2	SCUBE1 MEGF8 EFEMP2 SLIT3 CUBN VWCE F7	9.33e-05	265	75	7	PS01186
Domain	-	ZCCHC12 LIN28B LIN28A	1.51e-04	26	75	3	4.10.60.10
Domain	ZF_CCHC	ZCCHC12 LIN28B LIN28A	3.71e-04	35	75	3	PS50158
Domain	CSP	LIN28B LIN28A	4.39e-04	8	75	2	SM00357
Domain	Cold_shock_prot	LIN28B LIN28A	4.39e-04	8	75	2	IPR011129
Domain	CSD	LIN28B LIN28A	4.39e-04	8	75	2	PF00313
Domain	CSP_DNA-bd	LIN28B LIN28A	4.39e-04	8	75	2	IPR002059
Domain	CUB	SCUBE1 MEGF8 CUBN	1.00e-03	49	75	3	PF00431
Domain	CUB	SCUBE1 MEGF8 CUBN	1.06e-03	50	75	3	SM00042
Domain	-	SCUBE1 MEGF8 CUBN	1.19e-03	52	75	3	2.60.120.290
Domain	CUB	SCUBE1 MEGF8 CUBN	1.26e-03	53	75	3	PS01180
Domain	ZnF_C2HC	ZCCHC12 LIN28B LIN28A	1.40e-03	55	75	3	SM00343
Domain	Znf_CCHC	ZCCHC12 LIN28B LIN28A	1.40e-03	55	75	3	IPR001878
Domain	CUB_dom	SCUBE1 MEGF8 CUBN	1.56e-03	57	75	3	IPR000859
Domain	BTB	GMCL1 ZBTB38 ZBTB25 ZBTB41	1.91e-03	131	75	4	PF00651
Domain	zf-CCHC	LIN28B LIN28A	3.81e-03	23	75	2	PF00098
Domain	BTB	GMCL1 ZBTB38 ZBTB25 ZBTB41	3.93e-03	160	75	4	PS50097
Domain	NA-bd_OB-fold	LIN28B POT1 LIN28A	4.54e-03	83	75	3	IPR012340
Domain	cEGF	SCUBE1 EFEMP2	4.86e-03	26	75	2	IPR026823
Domain	cEGF	SCUBE1 EFEMP2	4.86e-03	26	75	2	PF12662
Domain	VWC	PXDNL VWCE	5.62e-03	28	75	2	PF00093
Domain	BTB	GMCL1 ZBTB38 ZBTB25 ZBTB41	5.96e-03	180	75	4	SM00225
Domain	BTB/POZ_dom	GMCL1 ZBTB38 ZBTB25 ZBTB41	6.56e-03	185	75	4	IPR000210
Domain	SKP1/BTB/POZ	GMCL1 ZBTB38 ZBTB25 ZBTB41	7.06e-03	189	75	4	IPR011333
Domain	VWFC_1	PXDNL VWCE	9.18e-03	36	75	2	PS01208
Domain	VWC	PXDNL VWCE	1.02e-02	38	75	2	SM00214
Domain	VWFC_2	PXDNL VWCE	1.02e-02	38	75	2	PS50184
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF771 KMT2C ZNF135 ZNF547 ZNF473 ZNF484 ZNF607 ZNF875 ZNF587 ZNF436 ZNF343 ZNF202 ZNF205 ZNF552 ZNF233 PPARD PPARG ZKSCAN4 ZNF417 ZNF546 ZNF707	5.89e-09	1387	52	21	M734
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF8 ZNF607 ZNF587 CENPV ZNF552 ZNF229 ZNF417 ZNF707	7.92e-09	181	78	8	37372979
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MYT1L GTF3A ZNF473 ZNF592 MKRN1 PXN ZNF202 ZNF205 ZBTB41 PPARD ZKSCAN4 ZNF646	2.43e-07	808	78	12	20412781
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	MYT1L KMT2C GTF3A ZNF436 MKRN1 EIF5 PXN ZNF217 EEA1 PPARD SNAI3	5.27e-07	709	78	11	22988430
Pubmed	A GO catalogue of human DNA-binding transcription factors.	ZNF592 ZNF818P ZNF511 ZNF233	2.46e-06	42	78	4	34673265
Pubmed	Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ gene.	PPARD PPARG	4.97e-06	2	78	2	24486511
Pubmed	Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma.	PPARD PPARG	4.97e-06	2	78	2	23374874
Pubmed	LIN28 expression and function in medulloblastoma.	LIN28B LIN28A	4.97e-06	2	78	2	36649308
Pubmed	The function of the nuclear receptor peroxisome proliferator-activated receptor delta in energy homeostasis.	PPARD PPARG	4.97e-06	2	78	2	14677574
Pubmed	Lin28B and Let-7 in the Control of Sympathetic Neurogenesis and Neuroblastoma Development.	LIN28B LIN28A	4.97e-06	2	78	2	26674877
Pubmed	Pleiotropic effects of peroxisome proliferator-activated receptor γ and δ in vascular diseases.	PPARD PPARG	4.97e-06	2	78	2	24107399
Pubmed	The Impact of PPARD and PPARG Polymorphisms on Glioma Risk and Prognosis.	PPARD PPARG	4.97e-06	2	78	2	32198386
Pubmed	High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer.	LIN28B LIN28A	4.97e-06	2	78	2	22433967
Pubmed	The function of peroxisome proliferator-activated receptors PPAR-γ and PPAR-δ in Mycobacterium leprae-induced foam cell formation in host macrophages.	PPARD PPARG	4.97e-06	2	78	2	33075048
Pubmed	Genomic organization of the mouse peroxisome proliferator-activated receptor beta/delta gene: alternative promoter usage and splicing yield transcripts exhibiting differential translational efficiency.	PPARD PPARG	4.97e-06	2	78	2	12059785
Pubmed	Lin28 promotes transformation and is associated with advanced human malignancies.	LIN28B LIN28A	4.97e-06	2	78	2	19483683
Pubmed	Association of peroxisome proliferator-activated receptor α/δ/γ with obesity, and gene-gene interaction, in the Chinese Han population.	PPARD PPARG	4.97e-06	2	78	2	23545576
Pubmed	Peroxisome proliferator-activated receptor-β/δ, the acute signaling factor in prostacyclin-induced pulmonary vasodilation.	PPARD PPARG	4.97e-06	2	78	2	22021335
Pubmed	+294T/C polymorphism in the PPAR-delta gene is associated with risk of coronary artery disease in normolipidemic Tunisians.	PPARD PPARG	4.97e-06	2	78	2	20645257
Pubmed	Comparison of the expression and function of Lin28A and Lin28B in colon cancer.	LIN28B LIN28A	4.97e-06	2	78	2	27793004
Pubmed	Sex-specific regulation of weight and puberty by the Lin28/let-7 axis.	LIN28B LIN28A	4.97e-06	2	78	2	26698568
Pubmed	PPARδ deficient mice develop elevated Th1/Th17 responses and prolonged experimental autoimmune encephalomyelitis.	PPARD PPARG	4.97e-06	2	78	2	21192919
Pubmed	Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.	LIN28B LIN28A	4.97e-06	2	78	2	22118463
Pubmed	Deregulation of tumor angiogenesis and blockade of tumor growth in PPARbeta-deficient mice.	PPARD PPARG	4.97e-06	2	78	2	17641685
Pubmed	Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA.	LIN28B LIN28A	4.97e-06	2	78	2	18951094
Pubmed	Endothelial, but not smooth muscle, peroxisome proliferator-activated receptor β/δ regulates vascular permeability and anaphylaxis.	PPARD PPARG	4.97e-06	2	78	2	25556996
Pubmed	[Effects of Lin28a and Lin28b on let-7 family activity].	LIN28B LIN28A	4.97e-06	2	78	2	22263265
Pubmed	Different expression patterns of Lin28 and Lin28b in mouse molar development.	LIN28B LIN28A	4.97e-06	2	78	2	28683410
Pubmed	Influence of tumor peroxisome proliferator-activated receptor gamma and delta expression on postoperative mortality of patients undergoing colorectal cancer surgery.	PPARD PPARG	4.97e-06	2	78	2	19283612
Pubmed	Cinnamaldehyde Contributes to Insulin Sensitivity by Activating PPARδ, PPARγ, and RXR.	PPARD PPARG	4.97e-06	2	78	2	26227398
Pubmed	Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway.	LIN28B LIN28A	4.97e-06	2	78	2	38612395
Pubmed	Genetic polymorphisms of peroxisome proliferator-activated receptors and the risk of cardiovascular morbidity and mortality in a community-based cohort in washington county, Maryland.	PPARD PPARG	4.97e-06	2	78	2	18288282
Pubmed	Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation.	PPARD PPARG	4.97e-06	2	78	2	17713572
Pubmed	Impact of peroxisome proliferator-activated receptors gamma and delta on adiposity in toddlers and preschoolers in the GENESIS Study.	PPARD PPARG	4.97e-06	2	78	2	18379566
Pubmed	The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury.	LIN28B LIN28A	4.97e-06	2	78	2	28536261
Pubmed	Expression of LIN28 and its regulatory microRNAs in adult adrenocortical cancer.	LIN28B LIN28A	4.97e-06	2	78	2	25200669
Pubmed	The contrasting roles of PPARδ and PPARγ in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue.	PPARD PPARG	4.97e-06	2	78	2	21843327
Pubmed	Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico.	PPARD PPARG	4.97e-06	2	78	2	32664384
Pubmed	PPARβ/δ activation protects against hepatic ischaemia-reperfusion injury.	PPARD PPARG	4.97e-06	2	78	2	37833850
Pubmed	Activation of PPARγ and δ by dietary punicic acid ameliorates intestinal inflammation in mice.	PPARD PPARG	4.97e-06	2	78	2	21736821
Pubmed	The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson's disease.	PPARD PPARG	4.97e-06	2	78	2	26028469
Pubmed	PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells.	PPARD PPARG	4.97e-06	2	78	2	21070867
Pubmed	Peroxisome proliferator-activated receptor-γ and -δ polymorphisms in women with polycystic ovary syndrome.	PPARD PPARG	4.97e-06	2	78	2	20840271
Pubmed	LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.	LIN28B LIN28A	4.97e-06	2	78	2	27320042
Pubmed	Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target.	LIN28B LIN28A	4.97e-06	2	78	2	25638158
Pubmed	Comparison of PPARδ and PPARγ in inhibiting the pro-inflammatory effects of C-reactive protein in endothelial cells.	PPARD PPARG	4.97e-06	2	78	2	19395102
Pubmed	PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages.	PPARD PPARG	4.97e-06	2	78	2	12740443
Pubmed	Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation.	KMT2C USP21	4.97e-06	2	78	2	18172164
Pubmed	Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28.	LIN28B LIN28A	4.97e-06	2	78	2	38216964
Pubmed	Investigation of peripubertal expression of Lin28a and Lin28b in C57BL/6 female mice.	LIN28B LIN28A	4.97e-06	2	78	2	23138112
Pubmed	PPARbeta/delta potentiates PPARgamma-stimulated adipocyte differentiation.	PPARD PPARG	4.97e-06	2	78	2	15247146
Pubmed	Activation of PPARδ in bone marrow endothelial progenitor cells improves their hematopoiesis-supporting ability after myelosuppressive injury.	PPARD PPARG	4.97e-06	2	78	2	38704134
Pubmed	Nuclear receptors of the peroxisome proliferator-activated receptor (PPAR) family in gestational diabetes: from animal models to clinical trials.	PPARD PPARG	4.97e-06	2	78	2	20427759
Pubmed	Gene-gene interaction between PPARδ and PPARγ is associated with abdominal obesity in a Chinese population.	PPARD PPARG	4.97e-06	2	78	2	23273766
Pubmed	Hepatitis B virus X protein upregulates Lin28A/Lin28B through Sp-1/c-Myc to enhance the proliferation of hepatoma cells.	LIN28B LIN28A	4.97e-06	2	78	2	23318446
Pubmed	The effects of kefir, koumiss, yogurt and commercial probiotic formulations on PPARα and PPAR-β/δ expressions in mouse kidney.	PPARD PPARG	4.97e-06	2	78	2	24205877
Pubmed	Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells.	AOC3 VAV1	4.97e-06	2	78	2	1375396
Pubmed	Peroxisome-proliferator-activated receptors γ and β/δ mediate vascular endothelial growth factor production in colorectal tumor cells.	PPARD PPARG	4.97e-06	2	78	2	20221637
Pubmed	Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-δ/β overexpression.	PPARD PPARG	4.97e-06	2	78	2	24681603
Pubmed	Activation of PPARbeta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release.	PPARD PPARG	4.97e-06	2	78	2	19389799
Pubmed	Association between peroxisome proliferator-activated receptor-alpha, delta, and gamma polymorphisms and risk of coronary heart disease: A case-control study and meta-analysis.	PPARD PPARG	1.49e-05	3	78	2	27512842
Pubmed	Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.	PPARD PPARG	1.49e-05	3	78	2	9113987
Pubmed	Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase.	PPARD PPARG	1.49e-05	3	78	2	29346772
Pubmed	Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart.	PPARD PPARG	1.49e-05	3	78	2	20075336
Pubmed	Changes in plasma PPARs levels in migraine patients.	PPARD PPARG	1.49e-05	3	78	2	25758678
Pubmed	Modulating Intrafollicular Hormonal Milieu in Controlled Ovarian Stimulation: Insights From PPAR Expression in Human Granulosa Cells.	PPARD PPARG	1.49e-05	3	78	2	26332656
Pubmed	PPARβ/δ Agonism Upregulates Forkhead Box A2 to Reduce Inflammation in C2C12 Myoblasts and in Skeletal Muscle.	PPARD PPARG	1.49e-05	3	78	2	32143325
Pubmed	TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation.	LIN28B LIN28A	1.49e-05	3	78	2	19703396
Pubmed	Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta.	PPARD PPARG	1.49e-05	3	78	2	15917308
Pubmed	Association and interaction of PPARα, δ, and γ gene polymorphisms with low-density lipoprotein-cholesterol in a Chinese Han population.	PPARD PPARG	1.49e-05	3	78	2	26098621
Pubmed	Roles of PPARs on regulating myocardial energy and lipid homeostasis.	PPARD PPARG	1.49e-05	3	78	2	17356846
Pubmed	Roles of PPAR transcription factors in the energetic metabolic switch occurring during adult neurogenesis.	PPARD PPARG	1.49e-05	3	78	2	27860527
Pubmed	Polymorphisms in PPARD, PPARG and APM1 associated with four types of traditional Chinese medicine constitutions.	PPARD PPARG	1.49e-05	3	78	2	20621019
Pubmed	Gene-gene interactions among PPARα/δ/γ polymorphisms for hypertriglyceridemia in Chinese Han population.	PPARD PPARG	1.49e-05	3	78	2	23262340
Pubmed	Association of polymorphisms of peroxisome proliferator activated receptors in early and late onset of type 2 diabetes mellitus.	PPARD PPARG	1.49e-05	3	78	2	28292576
Pubmed	Peroxisome proliferator-activated receptors in squamous cell carcinoma and its precursors.	PPARD PPARG	1.49e-05	3	78	2	15811118
Pubmed	Role of UCP2 in the protective effects of PPARβ/δ activation on lipopolysaccharide-induced endothelial dysfunction.	PPARD PPARG	1.49e-05	3	78	2	27179975
Pubmed	[Effects of PPARD-87T > C and interactions with single nucleotide polymorphisms in PPARA and PPARG on abdominal obesity].	PPARD PPARG	1.49e-05	3	78	2	22944052
Pubmed	Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study.	PPARD PPARG	1.49e-05	3	78	2	15128052
Pubmed	Let-7a mimic attenuates CCL18 induced breast cancer cell metastasis through Lin 28 pathway.	LIN28B LIN28A	1.49e-05	3	78	2	26898455
Pubmed	Ligand modulated antagonism of PPARgamma by genomic and non-genomic actions of PPARdelta.	PPARD PPARG	1.49e-05	3	78	2	19756148
Pubmed	Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells.	PPARD PPARG	1.49e-05	3	78	2	21765467
Pubmed	The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review.	PPARD PPARG	1.49e-05	3	78	2	29762540
Pubmed	Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.	LIN28B LIN28A	1.49e-05	3	78	2	31379107
Pubmed	Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity.	PPARD PPARG	1.49e-05	3	78	2	18657264
Pubmed	Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity.	PPARD PPARG	1.49e-05	3	78	2	18323470
Pubmed	PPAR activation as a regulator of lipid metabolism, nitric oxide production and lipid peroxidation in the placenta from type 2 diabetic patients.	PPARD PPARG	1.49e-05	3	78	2	23811234
Pubmed	Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation.	MKRN1 PPARG	1.49e-05	3	78	2	24336050
Pubmed	Sjögren Syndrome antigen B regulates LIN28-let-7 axis in Caenorhabditis elegans and human.	LIN28B LIN28A	1.49e-05	3	78	2	33484878
Pubmed	Effects of PPARs/20-HETE on the renal impairment under diabetic conditions.	PPARD PPARG	1.49e-05	3	78	2	31163124
Pubmed	Identification of two mPPAR related receptors and evidence for the existence of five subfamily members.	PPARD PPARG	1.49e-05	3	78	2	8240342
Pubmed	Effects of peroxisome proliferator-activated receptors, dietary fat intakes and gene-diet interactions on peak particle diameters of low-density lipoproteins.	PPARD PPARG	1.49e-05	3	78	2	21487230
Pubmed	Genetic manipulations of PPARs: effects on obesity and metabolic disease.	PPARD PPARG	1.49e-05	3	78	2	17389768
Pubmed	Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma.	PPARD PPARG	1.49e-05	3	78	2	15578089
Pubmed	PPAR and GST polymorphisms may predict changes in intellectual functioning in medulloblastoma survivors.	PPARD PPARG	1.49e-05	3	78	2	30607709
Pubmed	Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.	PPARD PPARG	1.49e-05	3	78	2	18522830
Pubmed	PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration.	PPARD PPARG	1.49e-05	3	78	2	20238044
Pubmed	Lin28a is dormant, functional, and dispensable during mouse oocyte-to-embryo transition.	LIN28B LIN28A	1.49e-05	3	78	2	24829024
Pubmed	Peroxisome proliferator-activated receptors, orphans with ligands and functions.	PPARD PPARG	1.49e-05	3	78	2	9211064
Pubmed	Selective intranuclear redistribution of PPAR isoforms by RXR alpha.	PPARD PPARG	1.49e-05	3	78	2	11923467
Pubmed	Screening of Peroxisome Proliferator-Activated Receptors (PPARs) α, γ and α Gene Polymorphisms for Obesity and Metabolic Syndrome Association in the Multi-Ethnic Malaysian Population.	PPARD PPARG	1.49e-05	3	78	2	26673968
Interaction	ZNF837 interactions	ZNF473 ZNF587 EFEMP2 ZNF202 ZNF552 PPARD ZNF417	1.74e-08	79	75	7	int:ZNF837
Interaction	CCDC125 interactions	ZNF587 ZNF436 ZNF343 ZNF552 ZNF417	5.03e-06	67	75	5	int:CCDC125
Interaction	TRIM41 interactions	ZBTB38 ZNF473 ZNF587 ZNF343 ZNF552 ZNF417 BRAP	1.94e-05	223	75	7	int:TRIM41
Interaction	MDFI interactions	ZNF607 ZBTB25 ZNF587 EFEMP2 ZNF205 ZNF578 ZNF417 ZNF646 ZNF707	3.05e-05	430	75	9	int:MDFI
Interaction	ZNF547 interactions	ZNF547 ZNF587 ZNF417	3.24e-05	17	75	3	int:ZNF547
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF8 ZNF135 ZNF547 ZNF473 MEGF8 ZNF607 ZNF875 ZNF587 ZNF818P ZNF552 ZNF578 ZNF233 ZNF229 ZNF417 ZNF546	1.43e-09	1192	78	15	chr19q13
Cytoband	19q13.43	ZNF8 ZNF547 ZNF587 ZNF552 ZNF417	4.12e-07	87	78	5	19q13.43
Cytoband	19q13.31	ZNF233 ZNF229	1.12e-03	29	78	2	19q13.31
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF8 ZNF771 SCRT2 ZNF135 ZBTB38 ZNF547 GTF3A ZNF473 ZNF484 ZNF607 ZNF592 ZBTB25 ZNF875 ZNF587 ZNF436 ZNF343 ZNF511 ZNF202 ZNF205 ZNF552 ZNF578 ZNF233 ZBTB41 ZNF217 ZNF229 ZKSCAN4 ZNF417 SNAI3 CASZ1 ZNF546 ZNF646 ZNF707	2.13e-28	718	63	32	28
GeneFamily	Zinc fingers C2H2-type\|SNAG transcriptional repressors	SCRT2 SNAI3	5.28e-04	10	63	2	1259
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	GMCL1 ZBTB38 ZBTB25 ZBTB41	1.23e-03	134	63	4	861
GeneFamily	Zinc fingers CCHC-type\|RNA binding motif containing	ZCCHC12 LIN28A	3.40e-03	25	63	2	74
Disease	aortic aneurysm (implicated_via_orthology)	EFEMP2 AOC3	5.21e-05	5	68	2	DOID:3627 (implicated_via_orthology)
Disease	protein-glutamine gamma-glutamyltransferase e measurement	SLC5A6 PXN ITGA1	3.65e-04	60	68	3	EFO_0020690
Disease	waist circumference	ZNF771 ZBTB38 PXDNL SLIT3 PKHD1 PPARG	4.67e-04	429	68	6	EFO_0004342
Disease	unipolar depression, response to selective serotonin reuptake inhibitor, mood disorder	MYT1L FSTL4	6.96e-04	17	68	2	EFO_0003761, EFO_0004247, EFO_0005658
Disease	coagulation factor measurement	ZBTB41 F7	9.68e-04	20	68	2	EFO_0004634
Disease	Left ventricular mass to end-diastolic volume ratio	ZNF592 PXN	1.52e-03	25	68	2	EFO_0010556
Disease	mean arterial pressure, alcohol drinking	SLIT3 CASZ1 BRAP	1.52e-03	98	68	3	EFO_0004329, EFO_0006340
Disease	type 2 diabetes mellitus (implicated_via_orthology)	AOC3 PPARD F7	1.86e-03	105	68	3	DOID:9352 (implicated_via_orthology)
Disease	pulmonary tuberculosis	MYT1L ZNF202	2.04e-03	29	68	2	EFO_1000049
Disease	caudate nucleus volume	MYT1L PPARG	2.18e-03	30	68	2	EFO_0004830
Disease	Diabetes Mellitus	AOC3 PPARG	2.48e-03	32	68	2	C0011849
Disease	diastolic blood pressure, alcohol drinking	SLIT3 CASZ1 BRAP	2.59e-03	118	68	3	EFO_0004329, EFO_0006336
Disease	melanoma	POT1 PPARD PPARG CUBN	2.60e-03	248	68	4	C0025202
Disease	primary dental caries	FSTL4 CUBN	2.80e-03	34	68	2	EFO_0600095
Disease	tea consumption measurement	PKHD1 LIN28A BRAP	3.33e-03	129	68	3	EFO_0010091
Disease	gluteofemoral adipose tissue measurement	LIN28B PKHD1 PPARG	3.55e-03	132	68	3	EFO_0803317
Disease	total blood protein measurement	ZBTB38 PKHD1 ITGA1 PPARD PPARG	3.79e-03	449	68	5	EFO_0004536
Disease	guilt measurement	LIN28B ZKSCAN4	3.86e-03	40	68	2	EFO_0009595
Disease	Nodular glomerulosclerosis	AOC3 PPARG	4.05e-03	41	68	2	C0017667
Disease	Neoplastic Cell Transformation	LIN28B PXN LIN28A	4.10e-03	139	68	3	C0007621

Protein segments in the cluster

Peptide	Gene	Start	Entry
ICGHIGCGRYVSRHA	BRAP	331	Q7Z569
GCGRYVSRHAYKHFE	BRAP	336	Q7Z569
HYCVLGCESFISGRH	BTN3A1	381	O00481
YSKATNHFHCIRAGC	CASZ1	661	Q86V15
FRMRGHYHCLRTGCY	CASZ1	1236	Q86V15
ASGLLHHCCFYKHRG	AOC3	191	Q16853
HGFCYCAGSHKRKRS	GMCL1	41	Q96IK5
CSVGYHLFSCHRSEK	PAQR3	121	Q6TCH7
SRECVHSYCEHGGFV	POC1A	176	Q8NBT0
HKTGATSGCHRFRCT	KMT2C	4466	Q8NEZ4
TSGCHRFRCTNIYHF	KMT2C	4471	Q8NEZ4
HTMGLSCFRICHYAG	MYO1A	496	Q9UBC5
GDRCYNCGGLDHHAK	LIN28B	126	Q6ZN17
SFHSHCRKRGPGFCD	MEGF8	1166	Q7Z7M0
YRCGHLHYTTGICSD	ITGA1	136	P56199
HYHERRGSLCSGCQK	PXN	526	P49023
LYHGRSHSCKTFGNR	OXR1	841	Q8N573
RCFHAKYRAHDGTCN	PXDNL	721	A1KZ92
ASFHKSCGGYLHADR	CUBN	2086	O60494
CGKGFSVTVRRHHCR	EEA1	1361	Q15075
SCKACGYRGMLDTHH	EIF5	121	P55010
CYHCSEGGEAHSCRR	CDK15	16	Q96Q40
CGSDGRFYENHCKLH	FSTL4	101	Q6MZW2
TVCYGRPRTSHHGCF	FSCN3	81	Q9NQT6
VKHTGGCHCGAVRFE	CENPV	146	Q7Z7K6
CYKQEGCHTASRSGH	KLHDC9	176	Q8NEP7
AVAEYGRCRHGCHSS	KRTAP20-4	26	Q3LI62
CRCHQGYELHRDGFS	EFEMP2	226	O95967
CGCHQKYALHSDGRT	SCUBE1	226	Q8IWY4
AAQCGRHHEKRASYG	NIT1	256	Q86X76
EHAGRYCCIYGSHTA	LILRA3	91	Q8N6C8
HGVCKEGDNCRYSHD	MKRN1	66	Q9UHC7
GGHRHACAECGKTYA	SCRT2	151	Q9NQ03
ASGFHYGVHACEGCK	PPARD	81	Q03181
HTLCRRCGSKAYHLQ	RPL37	16	P61927
SCQKRLHCRSYGQDH	SLC5A6	576	Q9Y289
YCSDHTGTKRSCRCH	F7	161	P08709
ASGFHYGVHACEGCK	PPARG	146	P37231
GTIHHYGCKQCSSLR	POT1	496	Q9NUX5
RLGFHIRGHKCSSCE	PKHD1	3101	P08F94
HTGEKPYACSHCSRA	SNAI3	231	Q3KNW1
KIHLCHYCGERFDSR	ZBTB25	236	P24278
RCHHGKCVATGTSYM	SLIT3	1376	O75094
YHTLHGNVCSFCKRA	ZNF511	101	Q8NB15
RLHLTKRFYECGHCG	ZNF707	336	Q96C28
THSGEKHYVCRECRR	ZNF343	486	Q6P1L6
HSGEKHYVCRECGRG	ZNF343	571	Q6P1L6
HYVCRECGRGFSHKS	ZNF343	576	Q6P1L6
SGSVHYGHYTALCRC	USP21	511	Q9UK80
RYHICSHCGKAFSQI	ZNF436	136	Q9C0F3
YKSSLTCHHRCHTGE	ZNF578	326	Q96N58
HTGEKPYACAHCGRR	ZNF771	141	Q7L3S4
YECHDCGKSFRQSTH	ZNF135	606	P52742
ELQLRYHCCGRHGYK	ROM1	161	Q03395
YAKSCGRYRCRLHHT	TOMT	256	Q8WZ04
YQGYRCHRCRASAHK	VAV1	541	P15498
HTGERAYHCGECGKS	ZNF587	346	Q96SQ5
LHYARKVGYRCIHCG	ZNF592	791	Q92610
CGKCFGRRDHLTVHY	ZBTB41	636	Q5SVQ8
HTGERAYHCGECGKS	ZNF417	346	Q8TAU3
RCGKAFHCASYLVRH	ZNF607	621	Q96SK3
ECTECGKTFSRHYHL	ZNF546	666	Q86UE3
YKCSCRTGFHLHGNR	VWCE	201	Q96DN2
KCSECGRAYRHRGSL	ZNF646	466	O15015
AFACRDCGKSYRHSG	ZNF646	616	O15015
RCHVCGKGYSQSSHL	ZNF229	741	Q9UJW7
GSRRHYCHECGKSFA	ZKSCAN4	316	Q969J2
YACTDCGKRFGRSSH	ZNF205	336	O95201
HYRIHTGKRSYGCSE	ZNF547	286	Q8IVP9
CVSLFHGGKSHYSCG	ZNF552	201	Q9H707
PYECNHCGKGFRHSS	ZNF8	396	P17098
CYHGHRSVCSGYLAD	ZNRF3	531	Q9ULT6
TCGRCGKGFHHSLDF	ZNF233	371	A6NK53
HTGERHYECSECGKA	ZNF484	546	Q5JVG2
HTGERHYECSECGKA	ZNF484	686	Q5JVG2
RIHTGEKSYRCHECG	ZNF818P	81	Q6ZRF7
HCSECGKAFRTYHQL	ZNF217	376	O75362
GCGKAFIRDYHLSRH	GTF3A	76	Q92664
HKRAHSGAFVCRECG	ZNF875	571	P10072
RIHTGEKRYHCQFCF	ZBTB38	1086	Q8NAP3
CGKSFSRGYHLIRHQ	ZNF202	626	O95125
RKHTIRCSYCGEEGH	ZCCHC12	341	Q6PEW1
YKCSECGKAFHRHTH	ZNF473	431	Q8WTR7
GDRCYNCGGLDHHAK	LIN28A	136	Q9H9Z2
HVSGKYARHRSVYGC	MYT1L	41	Q9UL68