Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ligase activity, forming carbon-oxygen bonds	WARS1 GARS1 TARS3 TARS1	8.60e-05	42	111	4	GO:0016875
GeneOntologyMolecularFunction	aminoacyl-tRNA ligase activity	WARS1 GARS1 TARS3 TARS1	8.60e-05	42	111	4	GO:0004812
GeneOntologyMolecularFunction	soluble NSF attachment protein activity	NAPA NAPB	9.15e-05	3	111	2	GO:0005483
GeneOntologyMolecularFunction	threonine-tRNA ligase activity	TARS3 TARS1	9.15e-05	3	111	2	GO:0004829
GeneOntologyMolecularFunction	alkylglycerophosphoethanolamine phosphodiesterase activity	GNA11 GNAQ	3.03e-04	5	111	2	GO:0047391
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	SYNJ1 SYNJ2	4.53e-04	6	111	2	GO:0043813
GeneOntologyMolecularFunction	pyrophosphatase activity	KIF26A GARS1 RNF213 RGS11 RGS1 IFIH1 GUF1 DDX54 GNA11 ABCC12 GNAQ ASCC3 ALPL	7.78e-04	839	111	13	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	KIF26A GARS1 RNF213 RGS11 RGS1 IFIH1 GUF1 DDX54 GNA11 ABCC12 GNAQ ASCC3 ALPL	7.87e-04	840	111	13	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	KIF26A GARS1 RNF213 RGS11 RGS1 IFIH1 GUF1 DDX54 GNA11 ABCC12 GNAQ ASCC3 ALPL	7.87e-04	840	111	13	GO:0016818
GeneOntologyMolecularFunction	inositol-1,4,5-trisphosphate 5-phosphatase activity	SYNJ1 SYNJ2	8.39e-04	8	111	2	GO:0052658
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	CDC42BPB CCNH EGFR MAST1 TNK2 ROCK1 CDK1 MAPK3 MAPK4	8.64e-04	446	111	9	GO:0004674
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	KIF26A RNF213 RGS11 RGS1 IFIH1 GUF1 DDX54 GNA11 ABCC12 GNAQ ASCC3 ALPL	1.26e-03	775	111	12	GO:0017111
GeneOntologyMolecularFunction	phosphorylation-dependent protein binding	TOPBP1 PLCG2	1.34e-03	10	111	2	GO:0140031
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	SYNJ1 SYNJ2	1.34e-03	10	111	2	GO:0004439
GeneOntologyMolecularFunction	phosphatidylinositol phosphate 4-phosphatase activity	SYNJ1 SYNJ2	1.34e-03	10	111	2	GO:0034596
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	SYNJ1 SYNJ2	1.63e-03	11	111	2	GO:0052629
GeneOntologyMolecularFunction	protein kinase activity	INSR CDC42BPB CCNH EGFR MAST1 TNK2 ROCK1 CDK1 MAPK3 MAPK4	1.89e-03	600	111	10	GO:0004672
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate phosphatase activity	SYNJ1 SYNJ2	1.95e-03	12	111	2	GO:0106019
GeneOntologyMolecularFunction	enzyme regulator activity	DOCK1 GIPC1 DENND2A ERCC5 WARS1 SERPINF1 TOPBP1 RGS11 RGS1 CCNH EGFR CCNB3 PPP4R2 TNK2 ROCK1 GNA11 GNAQ	2.10e-03	1418	111	17	GO:0030234
GeneOntologyMolecularFunction	STAT family protein binding	FAM220A PPARG	2.29e-03	13	111	2	GO:0097677
GeneOntologyMolecularFunction	phosphatidylinositol phosphate 5-phosphatase activity	SYNJ1 SYNJ2	2.29e-03	13	111	2	GO:0034595
GeneOntologyBiologicalProcess	heart development	NDST1 NCKAP1 INSR PPARA SETD2 SCUBE1 SALL1 EGFR ROCK1 GNA11 CDK1 GNAQ MAPK3 HECTD1 FKBP1A	1.18e-05	757	110	15	GO:0007507
GeneOntologyBiologicalProcess	circulatory system development	NDST1 WARS1 NCKAP1 SERPINF1 INSR VASH1 RNF213 PPARA PPARG SVEP1 SETD2 SCUBE1 SALL1 EGFR ROCK1 GNA11 CDK1 GNAQ MAPK3 HECTD1 FKBP1A	2.16e-05	1442	110	21	GO:0072359
GeneOntologyBiologicalProcess	negative regulation of macrophage derived foam cell differentiation	PPARA PPARG CRP	6.41e-05	15	110	3	GO:0010745
GeneOntologyBiologicalProcess	tRNA aminoacylation for protein translation	WARS1 GARS1 TARS3 TARS1	7.33e-05	42	110	4	GO:0006418
GeneOntologyBiologicalProcess	threonyl-tRNA aminoacylation	TARS3 TARS1	8.43e-05	3	110	2	GO:0006435
GeneOntologyBiologicalProcess	SNARE complex disassembly	NAPA NAPB	8.43e-05	3	110	2	GO:0035494
GeneOntologyBiologicalProcess	regulation of circadian rhythm	PPARA PPARG EZH2 GNA11 CDK1 GNAQ	8.63e-05	135	110	6	GO:0042752
GeneOntologyBiologicalProcess	placenta development	VASH1 PPARG SETD2 EGFR MAPK3 CTSB HECTD1	9.04e-05	197	110	7	GO:0001890
GeneOntologyBiologicalProcess	cellular response to organic cyclic compound	SERPINF1 PPARA PPARG EZH2 IFIH1 EGFR DDX54 GNA11 CDK1 GNAQ NR1H4 ALPL	9.34e-05	605	110	12	GO:0071407
GeneOntologyBiologicalProcess	tRNA aminoacylation	WARS1 GARS1 TARS3 TARS1	9.64e-05	45	110	4	GO:0043039
GeneOntologyBiologicalProcess	amino acid activation	WARS1 GARS1 TARS3 TARS1	1.05e-04	46	110	4	GO:0043038
GeneOntologyBiologicalProcess	response to nitrogen compound	INSR PPARA PPARG EZH2 IFIH1 EDEM3 ZNF106 SETD2 EGFR ROCK1 GNA11 CDK1 PLCG2 GNAQ MAPK3 FKBP1A NR1H4 ALPL	1.31e-04	1272	110	18	GO:1901698
GeneOntologyBiologicalProcess	response to organic cyclic compound	SERPINF1 PPARA PPARG EZH2 IFIH1 SETD2 EGFR DDX54 GNA11 CDK1 PLCG2 GNAQ MAPK3 FKBP1A NR1H4 ALPL	1.37e-04	1048	110	16	GO:0014070
GeneOntologyBiologicalProcess	peptidyl-tyrosine autophosphorylation	INSR EGFR MAPK3	2.11e-04	22	110	3	GO:0038083
MousePheno	abnormal foot pad morphology	EGFR GNA11 PLCG2 GNAQ	1.80e-05	26	86	4	MP:0000574
Domain	HGTP_anticodon	GARS1 TARS3 TARS1	1.58e-05	9	109	3	PF03129
Domain	aa-tRNA-synt_IIb	GARS1 TARS3 TARS1	3.08e-05	11	109	3	IPR002314
Domain	-	GARS1 TARS3 TARS1	3.08e-05	11	109	3	3.40.50.800
Domain	tRNA-synt_2b	GARS1 TARS3 TARS1	3.08e-05	11	109	3	PF00587
Domain	DUF1866	SYNJ1 SYNJ2	3.37e-05	2	109	2	IPR015047
Domain	DUF1866	SYNJ1 SYNJ2	3.37e-05	2	109	2	PF08952
Domain	DUF1866	SYNJ1 SYNJ2	3.37e-05	2	109	2	SM01165
Domain	Anticodon-bd	GARS1 TARS3 TARS1	6.72e-05	14	109	3	IPR004154
Domain	NSF_attach	NAPA NAPB	1.01e-04	3	109	2	IPR000744
Domain	1Cnucl_rcpt	PPARA PPARG	1.01e-04	3	109	2	IPR003074
Domain	ThrRS_core	TARS3 TARS1	1.01e-04	3	109	2	IPR033728
Domain	Thr-tRNA-ligase_IIa	TARS3 TARS1	1.01e-04	3	109	2	IPR002320
Domain	aa-tRNA-synth_II	GARS1 TARS3 TARS1	1.48e-04	18	109	3	IPR006195
Domain	AA_TRNA_LIGASE_II	GARS1 TARS3 TARS1	1.48e-04	18	109	3	PS50862
Domain	Gprotein_alpha_Q	GNA11 GNAQ	2.01e-04	4	109	2	IPR000654
Domain	WHEP_TRS_1	WARS1 GARS1	3.34e-04	5	109	2	PS00762
Domain	WHEP-TRS	WARS1 GARS1	3.34e-04	5	109	2	SM00991
Domain	WHEP-TRS	WARS1 GARS1	3.34e-04	5	109	2	PF00458
Domain	WHEP-TRS_dom	WARS1 GARS1	3.34e-04	5	109	2	IPR000738
Domain	Syja_N	SYNJ1 SYNJ2	3.34e-04	5	109	2	PF02383
Domain	WHEP_TRS_2	WARS1 GARS1	3.34e-04	5	109	2	PS51185
Domain	SAC	SYNJ1 SYNJ2	3.34e-04	5	109	2	PS50275
Domain	SAC_dom	SYNJ1 SYNJ2	3.34e-04	5	109	2	IPR002013
Domain	THIOL_PROTEASE_CYS	CAPN13 CAPN5 CTSB	4.56e-04	26	109	3	PS00139
Domain	TGS	TARS3 TARS1	4.99e-04	6	109	2	IPR004095
Domain	TGS	TARS3 TARS1	4.99e-04	6	109	2	PF02824
Domain	-	WARS1 GARS1	4.99e-04	6	109	2	1.10.287.10
Domain	THIOL_PROTEASE_ASN	CAPN13 CAPN5 CTSB	5.11e-04	27	109	3	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN13 CAPN5 CTSB	5.11e-04	27	109	3	PS00639
Domain	tRNA_SAD	TARS3 TARS1	6.95e-04	7	109	2	IPR012947
Domain	Recep_L_domain	INSR EGFR	6.95e-04	7	109	2	PF01030
Domain	Furin-like	INSR EGFR	6.95e-04	7	109	2	PF00757
Domain	Rcpt_L-dom	INSR EGFR	6.95e-04	7	109	2	IPR000494
Domain	TGS-like	TARS3 TARS1	6.95e-04	7	109	2	IPR012676
Domain	tRNA_SAD	TARS3 TARS1	6.95e-04	7	109	2	SM00863
Domain	Furin-like_Cys-rich_dom	INSR EGFR	6.95e-04	7	109	2	IPR006211
Domain	-	INSR EGFR	6.95e-04	7	109	2	3.80.20.20
Domain	tRNA_SAD	TARS3 TARS1	6.95e-04	7	109	2	PF07973
Domain	S15_NS1_RNA-bd	WARS1 GARS1	9.24e-04	8	109	2	IPR009068
Domain	Thr/Ala-tRNA-synth_IIc_edit	TARS3 TARS1	9.24e-04	8	109	2	IPR018163
Domain	P-loop_NTPase	NDST1 KIF26A MYH7B RNF213 IFIH1 GUF1 NLRP9 SULT2A1 DDX54 GNA11 ABCC12 GNAQ ASCC3	1.32e-03	848	109	13	IPR027417
Domain	PROTEIN_KINASE_ATP	INSR CDC42BPB EGFR MAST1 TNK2 ROCK1 CDK1 MAPK3 MAPK4	1.47e-03	459	109	9	PS00107
Domain	IPPc	SYNJ1 SYNJ2	1.47e-03	10	109	2	IPR000300
Domain	PTX	SVEP1 CRP	1.47e-03	10	109	2	SM00159
Domain	IPPc	SYNJ1 SYNJ2	1.47e-03	10	109	2	SM00128
Domain	Protein_kinase_ATP_BS	INSR CDC42BPB EGFR TNK2 ROCK1 CDK1 MAPK3 MAPK4	1.71e-03	379	109	8	IPR017441
Domain	Ephrin_rec_like	SVEP1 SCUBE1	1.79e-03	11	109	2	PF07699
Domain	Pentaxin-related	SVEP1 CRP	1.79e-03	11	109	2	IPR001759
Domain	Pentaxin	SVEP1 CRP	1.79e-03	11	109	2	PF00354
Domain	Pkinase_C	CDC42BPB MAST1 ROCK1	1.88e-03	42	109	3	PF00433
Domain	Prot_kinase_dom	INSR CDC42BPB EGFR MAST1 TNK2 ROCK1 CDK1 MAPK3 MAPK4	2.26e-03	489	109	9	IPR000719
Domain	PROTEIN_KINASE_DOM	INSR CDC42BPB EGFR MAST1 TNK2 ROCK1 CDK1 MAPK3 MAPK4	2.39e-03	493	109	9	PS50011
Domain	Znf_hrmn_rcpt	PPARA PPARG NR1H4	2.45e-03	46	109	3	IPR001628
Domain	NUCLEAR_REC_DBD_2	PPARA PPARG NR1H4	2.45e-03	46	109	3	PS51030
Domain	NUCLEAR_REC_DBD_1	PPARA PPARG NR1H4	2.45e-03	46	109	3	PS00031
Domain	ZnF_C4	PPARA PPARG NR1H4	2.45e-03	46	109	3	SM00399
Domain	zf-C4	PPARA PPARG NR1H4	2.45e-03	46	109	3	PF00105
Domain	Nuclear_hrmn_rcpt	PPARA PPARG NR1H4	2.45e-03	46	109	3	IPR001723
Domain	Calpain_III	CAPN13 CAPN5	2.52e-03	13	109	2	PF01067
Domain	Calpain_domain_III	CAPN13 CAPN5	2.52e-03	13	109	2	IPR022682
Domain	-	PPARA PPARG NR1H4	2.60e-03	47	109	3	1.10.565.10
Domain	Nucl_hrmn_rcpt_lig-bd	PPARA PPARG NR1H4	2.76e-03	48	109	3	IPR000536
Domain	HOLI	PPARA PPARG NR1H4	2.76e-03	48	109	3	SM00430
Domain	Hormone_recep	PPARA PPARG NR1H4	2.76e-03	48	109	3	PF00104
Domain	-	TARS3 TARS1	2.93e-03	14	109	2	3.10.20.30
Domain	Beta-grasp_dom	TARS3 TARS1	2.93e-03	14	109	2	IPR012675
Domain	Calpain_cysteine_protease	CAPN13 CAPN5	2.93e-03	14	109	2	IPR022684
Domain	Peptidase_C2	CAPN13 CAPN5	3.37e-03	15	109	2	PF00648
Domain	CysPc	CAPN13 CAPN5	3.37e-03	15	109	2	SM00230
Domain	Peptidase_C2_calpain_cat	CAPN13 CAPN5	3.37e-03	15	109	2	IPR001300
Domain	CALPAIN_CAT	CAPN13 CAPN5	3.37e-03	15	109	2	PS50203
Domain	GproteinA_insert	GNA11 GNAQ	3.84e-03	16	109	2	IPR011025
Domain	-	GNA11 GNAQ	3.84e-03	16	109	2	1.10.400.10
Domain	G-alpha	GNA11 GNAQ	3.84e-03	16	109	2	PF00503
Domain	G_alpha	GNA11 GNAQ	3.84e-03	16	109	2	SM00275
Domain	-	NDST1 RNF213 IFIH1 GUF1 NLRP9 SULT2A1 DDX54 GNA11 ABCC12 GNAQ ASCC3	4.21e-03	746	109	11	3.40.50.300
Domain	AGC-kinase_C	CDC42BPB MAST1 ROCK1	4.28e-03	56	109	3	IPR000961
Domain	AGC_KINASE_CTER	CDC42BPB MAST1 ROCK1	4.28e-03	56	109	3	PS51285
Domain	S_TK_X	CDC42BPB MAST1 ROCK1	4.28e-03	56	109	3	SM00133
Domain	Gprotein_alpha_su	GNA11 GNAQ	4.33e-03	17	109	2	IPR001019
Domain	Kinase-like_dom	INSR CDC42BPB EGFR MAST1 TNK2 ROCK1 CDK1 MAPK3 MAPK4	4.47e-03	542	109	9	IPR011009
Domain	-	PPARA PPARG NR1H4	4.50e-03	57	109	3	3.30.50.10
Domain	Znf_NHR/GATA	PPARA PPARG NR1H4	4.73e-03	58	109	3	IPR013088
Domain	Furin_repeat	INSR EGFR	4.86e-03	18	109	2	IPR006212
Domain	FU	INSR EGFR	4.86e-03	18	109	2	SM00261
Pathway	WP_AGERAGE_PATHWAY	INSR EGFR ROCK1 MAPK3 ALPL	5.60e-05	66	88	5	M39420
Pathway	WP_GASTRIN_SIGNALING	PPARG EGFR ROCK1 GNAQ MAPK3 HDC	8.13e-05	115	88	6	M39866
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY	EGFR PLCG2 MAPK3	8.14e-05	14	88	3	M47383
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY	EGFR PLCG2 MAPK3	1.01e-04	15	88	3	M47382
Pathway	PID_THROMBIN_PAR4_PATHWAY	ROCK1 GNA11 GNAQ	1.01e-04	15	88	3	M138
Pathway	KEGG_AMINOACYL_TRNA_BIOSYNTHESIS	WARS1 GARS1 TARS3 TARS1	1.20e-04	41	88	4	M14691
Pathway	KEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY	PLCG2 GNAQ MAPK3	2.12e-04	19	88	3	M47596
Pathway	KEGG_GAP_JUNCTION	EGFR GNA11 CDK1 GNAQ MAPK3	2.45e-04	90	88	5	M4013
Pathway	WP_CORTICOTROPINRELEASING_HORMONE_SIGNALING	SULT2A1 GNA11 PLCG2 GNAQ MAPK3	2.71e-04	92	88	5	M39441
Pathway	KEGG_MEDICUS_REFERENCE_GNRH_GNRHR_PLCB_PKC_SIGNALING_PATHWAY	GNA11 GNAQ MAPK3	2.88e-04	21	88	3	M47638
Pathway	WP_REGULATION_OF_ACTIN_CYTOSKELETON	DOCK1 NCKAP1 EGFR ROCK1 MAPK3 MAPK4	3.47e-04	150	88	6	M39520
Pathway	WP_REGULATION_OF_ACTIN_CYTOSKELETON	DOCK1 NCKAP1 EGFR ROCK1 MAPK3 MAPK4	3.73e-04	152	88	6	MM15834
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_USP8_TO_EGFR_ERK_ACTH_SIGNALING_PATHWAY	EGFR MAPK3	3.81e-04	5	88	2	M49028
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_VPR_TO_WEE1_CELL_CYCLE_G2M	CCNB3 CDK1	3.81e-04	5	88	2	M49022
Pathway	WP_TCA_CYCLE_NUTRIENT_USE_AND_INVASIVENESS_OF_OVARIAN_CANCER	EGFR MAPK3	3.81e-04	5	88	2	M39621
Pathway	PID_TXA2PATHWAY	EGFR ROCK1 GNA11 GNAQ	4.07e-04	56	88	4	M99
Pathway	PID_S1P_S1P2_PATHWAY	GNA11 GNAQ MAPK3	4.33e-04	24	88	3	M268
Pathway	REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION	WARS1 GARS1 TARS1	4.33e-04	24	88	3	M6591
Pathway	BIOCARTA_AT1R_PATHWAY	EGFR GNAQ MAPK3	5.51e-04	26	88	3	MM1346
Pathway	PID_RXR_VDR_PATHWAY	PPARA PPARG NR1H4	5.51e-04	26	88	3	M162
Pathway	PID_TRKR_PATHWAY	DOCK1 GIPC1 SHC2 MAPK3	5.64e-04	61	88	4	M187
Pathway	BIOCARTA_SAM68_PATHWAY	CDK1 MAPK3	5.69e-04	6	88	2	M22052
Pathway	BIOCARTA_SAM68_PATHWAY	CDK1 MAPK3	5.69e-04	6	88	2	MM1567
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY	GNA11 GNAQ	5.69e-04	6	88	2	M47548
Pathway	BIOCARTA_AT1R_PATHWAY	EGFR GNAQ MAPK3	6.17e-04	27	88	3	M14899
Pathway	KEGG_GLIOMA	SHC2 EGFR PLCG2 MAPK3	7.18e-04	65	88	4	M1835
Pathway	PID_S1P_S1P3_PATHWAY	GNA11 GNAQ MAPK3	7.64e-04	29	88	3	M55
Pathway	KEGG_MEDICUS_REFERENCE_WEE1_CELL_CYCLE_G2_M	CCNB3 CDK1	7.93e-04	7	88	2	M47574
Pathway	REACTOME_SUPPRESSION_OF_APOPTOSIS	RNF213 MAPK3	7.93e-04	7	88	2	M29815
Pathway	PID_RETINOIC_ACID_PATHWAY	CCNH CDK1 MAPK3	8.45e-04	30	88	3	M207
Pathway	WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY	PPARA PPARG NR1H4	8.45e-04	30	88	3	MM15866
Pathway	REACTOME_SUMOYLATION_OF_INTRACELLULAR_RECEPTORS	PPARA PPARG NR1H4	8.45e-04	30	88	3	M27323
Pathway	REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS	GNA11 GNAQ MAPK3	1.02e-03	32	88	3	M861
Pathway	REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS	GNA11 GNAQ MAPK3	1.02e-03	32	88	3	MM15148
Pathway	REACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION	GNA11 GNAQ	1.05e-03	8	88	2	MM15032
Pathway	REACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION	GNA11 GNAQ	1.05e-03	8	88	2	M27356
Pathway	REACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION	GNA11 GNAQ	1.05e-03	8	88	2	MM15100
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PLCG_PKC_SIGNALING_PATHWAY	EGFR PLCG2	1.05e-03	8	88	2	M47479
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	GIPC1 NDST1 WARS1 PPFIBP1 CKAP5 NAPA DNAAF9 CDC42BPB GUF1 TARS3 SYNJ1 NAPB SACS VPS35L MAST1 CTSB HECTD1 TARS1 PCM1 ALPL BRWD1	8.20e-10	1285	112	21	35914814
Pubmed	RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.	ROCK1 GNA11 GNAQ	3.24e-07	5	112	3	25857352
Pubmed	A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes.	GIPC1 RGS11 RGS1 GNAQ	3.80e-07	19	112	4	11342430
Pubmed	ATRX proximal protein associations boast roles beyond histone deposition.	CCDC71L NOL10 EZH2 ZNF106 SALL1 DDX54	5.20e-07	91	112	6	34780483
Pubmed	Oxidized low density lipoprotein activates peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARgamma through MAPK-dependent COX-2 expression in macrophages.	PPARA PPARG MAPK3	6.46e-07	6	112	3	18208815
Pubmed	Expression of epidermal fatty acid binding protein (E-FABP) in septoclasts in the growth plate cartilage of mice.	PPARA PPARG CTSB	6.46e-07	6	112	3	24879443
Pubmed	GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner.	GNA11 GNAQ MAPK3	1.13e-06	7	112	3	20886089
Pubmed	High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.	PPARA PPARG NR1H4	1.13e-06	7	112	3	17272748
Pubmed	Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.	INSR PPARA PPARG CRP NR1H4	1.38e-06	59	112	5	20855565
Pubmed	Epigenetic modulation of signal transduction pathways in HPV-associated HNSCC.	PPARA PPARG EGFR	1.80e-06	8	112	3	23736812
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DENND2A WARS1 NCKAP1 CKAP5 CDC42BPB TARS3 SYNJ1 NAPB SACS CLMN PRICKLE2 OSBPL10 MAST1 GNAQ MAPK3 TARS1 PCM1	3.36e-06	1431	112	17	37142655
Pubmed	Genetics of dark skin in mice.	EGFR GNA11 GNAQ	3.84e-06	10	112	3	12533510
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	GIPC1 ERCC5 WARS1 PPFIBP1 CKAP5 SYNJ1 PPP4R2 ROCK1 ZBED1	3.95e-06	378	112	9	34315543
Pubmed	Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.	INSR EGFR TNK2 CDK1 MAPK3	4.56e-06	75	112	5	15951569
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DOCK1 INSR NAPA RNF213 PPARA SLC30A4 CDC42BPB SHC2 EGFR SYNJ2 CLMN VPS35L TTC21B MAST1 TNK2 HECTD1 PCM1	5.69e-06	1489	112	17	28611215
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CEP162 RNF213 NOL10 CDC42BPB CCNH CNNM3 EGFR PPP4R2 DDX54 EFR3B ROCK1 CDK1 MAPK3 L3MBTL3	7.31e-06	1049	112	14	27880917
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	ERCC5 INSR PPARG SLC30A4 CRP CCNH EGFR CTSB NR1H4	9.38e-06	421	112	9	19692168
Pubmed	Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.	PPARA PPARG CCNH CDK1	9.41e-06	41	112	4	17276355
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	VAPA WARS1 CDC42BPB CNNM3 PA2G4 PPP4R2 NXF2 GNA11 EBNA1BP2 MAPK3 MAPK4 CTSB PCM1	9.85e-06	931	112	13	27432908
Pubmed	Fluorescence imaging reveals the nuclear behavior of peroxisome proliferator-activated receptor/retinoid X receptor heterodimers in the absence and presence of ligand.	PPARA PPARG	1.03e-05	2	112	2	15731109
Pubmed	The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan.	GNA11 GNAQ	1.03e-05	2	112	2	28248732
Pubmed	Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice.	PPARA PPARG	1.03e-05	2	112	2	24244369
Pubmed	Peroxisome proliferator-activated receptors-alpha and gamma are targets to treat offspring from maternal diet-induced obesity in mice.	PPARA PPARG	1.03e-05	2	112	2	23700465
Pubmed	Roles of peroxisome proliferator-activated receptor-alpha and -gamma in the development of non-small cell lung cancer.	PPARA PPARG	1.03e-05	2	112	2	20081051
Pubmed	Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia.	VASH1 EZH2	1.03e-05	2	112	2	31815666
Pubmed	PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor.	PPARA PPARG	1.03e-05	2	112	2	12700342
Pubmed	Somatic mutation in the ACK1 ubiquitin association domain enhances oncogenic signaling through EGFR regulation in renal cancer derived cells.	EGFR TNK2	1.03e-05	2	112	2	20359967
Pubmed	Association of serum pigment epithelium-derived factor with high-sensitivity C-reactive protein in women with polycystic ovary syndrome.	SERPINF1 CRP	1.03e-05	2	112	2	24105071
Pubmed	The Synaptojanins in the murine small and large intestine.	SYNJ1 SYNJ2	1.03e-05	2	112	2	27878645
Pubmed	Molecular genetic testing of uveal melanoma from routinely processed and stained cytology specimens.	GNA11 GNAQ	1.03e-05	2	112	2	21945171
Pubmed	Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8).	PPARA SULT2A1	1.03e-05	2	112	2	28442498
Pubmed	PPARγ2 gene Pro12Ala and PPARα gene Leu162Val single nucleotide polymorphisms interact with dietary intake of fat in determination of plasma lipid concentrations.	PPARA PPARG	1.03e-05	2	112	2	22378291
Pubmed	85-kDa cPLA(2) plays a critical role in PPAR-mediated gene transcription in human hepatoma cells.	PPARA PPARG	1.03e-05	2	112	2	11897617
Pubmed	PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation.	PPARA PPARG	1.03e-05	2	112	2	20852389
Pubmed	Association between PPARs Gene Functional Polymorphisms and Ischemic Stroke in Chinese Uyghur Population.	PPARA PPARG	1.03e-05	2	112	2	30697628
Pubmed	Relationship between serum alkaline phosphatase level, C-reactive protein and leukocyte counts in adults aged 60 years or older.	CRP ALPL	1.03e-05	2	112	2	30888211
Pubmed	PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis.	PPARA PPARG	1.03e-05	2	112	2	11934839
Pubmed	Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy.	PPARA PPARG	1.03e-05	2	112	2	12594295
Pubmed	Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.	PPARA PPARG	1.03e-05	2	112	2	25516156
Pubmed	Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function.	PPARA PPARG	1.03e-05	2	112	2	32130908
Pubmed	Enhanced muscle by myostatin propeptide increases adipose tissue adiponectin, PPAR-alpha, and PPAR-gamma expressions.	PPARA PPARG	1.03e-05	2	112	2	18312853
Pubmed	Gonadotropin and gonadal steroid release in response to a gonadotropin-releasing hormone agonist in Gqalpha and G11alpha knockout mice.	GNA11 GNAQ	1.03e-05	2	112	2	9607776
Pubmed	Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling.	PPARA PPARG	1.03e-05	2	112	2	19179641
Pubmed	Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.	GNA11 GNAQ	1.03e-05	2	112	2	26628681
Pubmed	PPAR α and PPAR γ polymorphisms as risk factors for dyslipidemia in a Chinese Han population.	PPARA PPARG	1.03e-05	2	112	2	24460649
Pubmed	A Val227Ala polymorphism in the peroxisome proliferator activated receptor alpha (PPARalpha) gene is associated with variations in serum lipid levels.	PPARA PPARG	1.03e-05	2	112	2	11897821
Pubmed	The time-course of agonist-induced solubilization of trimeric G(q)alpha/G(11)alpha proteins resolved by two-dimensional electrophoresis.	GNA11 GNAQ	1.03e-05	2	112	2	17552882
Pubmed	Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice.	PPARA PPARG	1.03e-05	2	112	2	25557389
Pubmed	PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice.	PPARA PPARG	1.03e-05	2	112	2	37479780
Pubmed	Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas.	GNA11 GNAQ	1.03e-05	2	112	2	29209985
Pubmed	Combined effects of PPARgamma2 P12A and PPARalpha L162V polymorphisms on glucose and insulin homeostasis: the Québec Family Study.	PPARA PPARG	1.03e-05	2	112	2	14677049
Pubmed	[Effects of Pollen Typhae total flavones on mRNA expressions of peroxisome proliferator-activated receptors in 3T3-L1 adipocytes].	PPARA PPARG	1.03e-05	2	112	2	18782538
Pubmed	Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis.	GUF1 ALPL	1.03e-05	2	112	2	27065197
Pubmed	The role of alkaline phosphatase in intracellular lipid accumulation in the human hepatocarcinoma cell line, HepG2.	PPARG ALPL	1.03e-05	2	112	2	28209522
Pubmed	Distinct roles of Galpha(q) and Galpha11 for Purkinje cell signaling and motor behavior.	GNA11 GNAQ	1.03e-05	2	112	2	15175381
Pubmed	APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk.	PPARA PPARG	1.03e-05	2	112	2	19660836
Pubmed	PEDF and PEDF-derived peptide 44mer inhibit oxygen-glucose deprivation-induced oxidative stress through upregulating PPARγ via PEDF-R in H9c2 cells.	SERPINF1 PPARG	1.03e-05	2	112	2	26966066
Pubmed	Mutations in GNA11 in uveal melanoma.	GNA11 GNAQ	1.03e-05	2	112	2	21083380
Pubmed	GNAQ and GNA11 mutations in uveal melanoma.	GNA11 GNAQ	1.03e-05	2	112	2	25304237
Pubmed	Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.	GNA11 GNAQ	1.03e-05	2	112	2	28301547
Pubmed	Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation.	GNA11 GNAQ	1.03e-05	2	112	2	16847339
Pubmed	Moderating effect of ppar-γ on the association of c-reactive protein and ischemic stroke in patients younger than 60.	PPARG CRP	1.03e-05	2	112	2	34673211
Pubmed	NK2 receptor-mediated detrusor muscle contraction involves Gq/11-dependent activation of voltage-dependent Ca2+ channels and the RhoA-Rho kinase pathway.	GNA11 GNAQ	1.03e-05	2	112	2	31461351
Pubmed	SNX16 is required for hepatocellular carcinoma survival via modulating the EGFR-AKT signaling pathway.	SNX16 EGFR	1.03e-05	2	112	2	38849490
Pubmed	The PPARα and PPARγ Epigenetic Landscape in Cancer and Immune and Metabolic Disorders.	PPARA PPARG	1.03e-05	2	112	2	34638914
Pubmed	Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanoma.	GNA11 GNAQ	1.03e-05	2	112	2	23634288
Pubmed	Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism.	GNA11 GNAQ	1.03e-05	2	112	2	26368812
Pubmed	Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to cholecystokinin are mediated by a transient receptor potential-like current.	GNA11 GNAQ	1.03e-05	2	112	2	17482476
Pubmed	Peroxisome proliferator-activated receptors family is involved in the response to treatment and mild clinical course in patients with ulcerative colitis.	PPARA PPARG	1.03e-05	2	112	2	25548431
Pubmed	Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists.	PPARA PPARG	1.03e-05	2	112	2	23502212
Pubmed	Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.	GNA11 GNAQ	1.03e-05	2	112	2	24141786
Pubmed	Peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms in nonalcoholic fatty liver disease: a study in Brazilian patients.	PPARA PPARG	1.03e-05	2	112	2	23891824
Pubmed	Association of PPAR polymorphisms with cytokine levels in allergic rhinitis.	PPARA PPARG	1.03e-05	2	112	2	21785974
Pubmed	Increased expression of peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma in human atherosclerosis.	PPARA PPARG	1.03e-05	2	112	2	20399568
Pubmed	Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.	GNA11 GNAQ	1.03e-05	2	112	2	37102682
Pubmed	Structural insight into the crucial role of ligand chirality in the activation of PPARs by crystallographic methods.	PPARA PPARG	1.03e-05	2	112	2	21291392
Pubmed	Developmentally regulated alternative splicing in a novel synaptojanin.	SYNJ1 SYNJ2	1.03e-05	2	112	2	9442075
Pubmed	Gαq and Gα11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes.	GNA11 GNAQ	1.03e-05	2	112	2	22562663
Pubmed	Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF Inhibition.	EGFR TNK2	1.03e-05	2	112	2	33159968
Pubmed	Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons.	GNA11 GNAQ	1.03e-05	2	112	2	11826096
Pubmed	Blue nevi and variants: an update.	GNA11 GNAQ	1.03e-05	2	112	2	21366456
Pubmed	Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese.	CRP ALPL	1.03e-05	2	112	2	18605934
Pubmed	PPARalpha governs glycerol metabolism.	PPARA PPARG	1.03e-05	2	112	2	15232616
Pubmed	Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation.	PPARA PPARG	1.03e-05	2	112	2	18267111
Pubmed	Association of the PPARgamma gene polymorphism Pro12Ala with delayed onset of multiple sclerosis.	PPARA PPARG	1.03e-05	2	112	2	18977277
Pubmed	Skeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis.	GNA11 GNAQ	1.03e-05	2	112	2	30936140
Pubmed	Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11.	GNA11 GNAQ	1.03e-05	2	112	2	23778528
Pubmed	High throughput mass spectrometry-based mutation profiling of primary uveal melanoma.	GNA11 GNAQ	1.03e-05	2	112	2	22977135
Pubmed	PAR-5359, a well-balanced PPARalpha/gamma dual agonist, exhibits equivalent antidiabetic and hypolipidemic activities in vitro and in vivo.	PPARA PPARG	1.03e-05	2	112	2	18727927
Pubmed	An experimental strategy to probe Gq contribution to signal transduction in living cells.	GNA11 GNAQ	1.03e-05	2	112	2	33639168
Pubmed	Low mutational burden of eight genes involved in the MAPK/ERK, PI3K/AKT, and GNAQ/11 pathways in female genital tract primary melanomas.	GNA11 GNAQ	1.03e-05	2	112	2	25695059
Pubmed	Cardiac remodeling in Gαq and Gα11 knockout mice.	GNA11 GNAQ	1.03e-05	2	112	2	26476043
Pubmed	Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells.	PPARA PPARG	1.03e-05	2	112	2	20862655
Pubmed	Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study.	PPARA PPARG	1.03e-05	2	112	2	20825652
Pubmed	PPARalpha/gamma expression and activity in mouse and human melanocytes and melanoma cells.	PPARA PPARG	1.03e-05	2	112	2	18172578
Pubmed	PPARalpha gene expression is up-regulated by LXR and PXR activators in the small intestine.	PPARA NR1H4	1.03e-05	2	112	2	18448072
Pubmed	GNAQ and GNA11 mutations in melanocytomas of the central nervous system.	GNA11 GNAQ	1.03e-05	2	112	2	22307269
Pubmed	Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.	PPARA PPARG	1.03e-05	2	112	2	9013583
Pubmed	Activation of Gq/11 in the mouse corpus luteum is required for parturition.	GNA11 GNAQ	1.03e-05	2	112	2	25495873
Pubmed	Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development.	TARS3 TARS1	1.03e-05	2	112	2	37059185
Interaction	NUP210 interactions	VAPA CEP162 INSR NAPA EZH2 EGFR CDK1 CTSB	5.83e-06	174	112	8	int:NUP210
GeneFamily	X-linked mental retardation\|RNA helicases	IFIH1 ASCC3	8.87e-04	11	74	2	1168
GeneFamily	Nuclear hormone receptors	PPARA PPARG NR1H4	1.06e-03	49	74	3	71
GeneFamily	Mitogen-activated protein kinases	MAPK3 MAPK4	1.25e-03	13	74	2	651
GeneFamily	C2 domain containing\|Calpains	CAPN13 CAPN5	1.68e-03	15	74	2	975
GeneFamily	Aminoacyl tRNA synthetases, Class II	GARS1 TARS1	2.70e-03	19	74	2	132
GeneFamily	Regulators of G-protein signaling	RGS11 RGS1	3.30e-03	21	74	2	720
Coexpression	GSE17721_0.5H_VS_24H_PAM3CSK4_BMDC_UP	DOCK1 SERPINF1 PPARG CCNH PA2G4 DDX54 NIPA2 PLCG2 FKBP1A	1.75e-07	200	110	9	M4112
Coexpression	GSE25087_FETAL_VS_ADULT_TCONV_UP	RNF213 EZH2 RGS1 ZNF106 PPP4R2 CTSB TARS1	2.15e-05	199	110	7	M4645
Coexpression	GSE7568_IL4_VS_IL4_AND_DEXAMETHASONE_TREATED_MACROPHAGE_DN	ERCC5 INSR SYNJ1 GNA11 L3MBTL3 BRWD1	4.33e-05	151	110	6	M369
Coexpression	RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP	ONECUT2 WARS1 TOPBP1 CKAP5 IFIH1 EGFR OSBPL10 CDK1 ASCC3 HECTD1 TARS1 BRWD1	5.14e-05	721	110	12	M10237
Coexpression	LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN	GARS1 TOPBP1 CKAP5 EZH2 SACS CDK1	6.85e-05	164	110	6	M13108
Coexpression	OUYANG_PROSTATE_CANCER_MARKERS	INSR EZH2 CTSB	9.05e-05	21	110	3	M9874
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	ERCC5 SERPINF1 SNX16 CCNH IFIH1 SACS PPP4R2 OSBPL10 SNAPC1 HECTD1 PCM1	1.01e-04	656	110	11	M18979
Coexpression	FAN_OVARY_CL11_MURAL_GRANULOSA_CELL	VAPA PPFIBP1 GARS1 INSR PPARG EZH2 PPP4R2 SNAPC1 TARS1	1.09e-04	444	110	9	M41713
Coexpression	BUSSLINGER_GASTRIC_ISTHMUS_CELLS	GIPC1 PPFIBP1 GARS1 PPARG EDEM3 CLMN GNA11 CAPN5 MAPK3	1.37e-04	458	110	9	M40010
Coexpression	GSE20152_HTNFA_OVERXPRESS_ANKLE_VS_CTRL_SPHK1_KO_ANKLE_UP	PPFIBP1 PPARG SVEP1 CLMN TNK2 CAPN5	1.82e-04	196	110	6	M7687
Coexpression	BRUNO_HEMATOPOIESIS	SERPINF1 ZNF106 CAPN5 FKBP1A	1.84e-04	67	110	4	M1492
Coexpression	GSE3720_VD1_VS_VD2_GAMMADELTA_TCELL_UP	WARS1 MC2R RNF213 NLRP9 PRICKLE2 MAPK4	1.92e-04	198	110	6	M6361
Coexpression	GSE15330_LYMPHOID_MULTIPOTENT_VS_GRANULOCYTE_MONOCYTE_PROGENITOR_IKAROS_KO_UP	WARS1 TOPBP1 EZH2 SYNJ2 PPP4R2 CDK1	1.92e-04	198	110	6	M7046
Coexpression	GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP	FAM220A NAPA NAPB OSBPL10 PLCG2 SNAPC1	1.98e-04	199	110	6	M8107
Coexpression	GSE14308_TH2_VS_TH1_UP	ERCC5 SYNJ1 SACS ROCK1 ASCC3 TARS1	1.98e-04	199	110	6	M3359
Coexpression	GSE25088_WT_VS_STAT6_KO_MACROPHAGE_DN	DOCK1 INSR CKAP5 EZH2 CDK1 GNAQ	1.98e-04	199	110	6	M8031
Coexpression	GSE360_L_DONOVANI_VS_M_TUBERCULOSIS_DC_UP	GARS1 PPARG CCNH PVALB GNAQ TARS1	1.98e-04	199	110	6	M5205
Coexpression	GSE19888_CTRL_VS_A3R_ACTIVATION_MAST_CELL_UP	WARS1 CKAP5 RGS11 ZNF106 RPAP1 TNK2	1.98e-04	199	110	6	M7325
Coexpression	GSE6259_FLT3L_INDUCED_33D1_POS_DC_VS_BCELL_UP	PPARA SLC30A4 CDPF1 TNK2 SNAPC1 HECTD1	1.98e-04	199	110	6	M6741
Coexpression	GSE6674_ANTI_IGM_VS_ANTI_IGM_AND_CPG_STIM_BCELL_DN	GARS1 NOL10 DDX54 EBNA1BP2 FKBP1A TARS1	1.98e-04	199	110	6	M6935
Coexpression	GSE8685_IL2_ACT_IL2_STARVED_VS_IL15_ACT_IL2_STARVED_CD4_TCELL_DN	PPFIBP1 SERPINF1 FANCL SLC30A4 CNNM3 ASCC3	2.03e-04	200	110	6	M332
Coexpression	GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_ATOPIC_PATIENT_UP	VAPA CPZ CCNH SACS FKBP1A TARS1	2.03e-04	200	110	6	M7077
Coexpression	GSE17721_CTRL_VS_PAM3CSK4_0.5H_BMDC_DN	ERCC5 PPARA CNNM3 PA2G4 MAST1 BRWD1	2.03e-04	200	110	6	M3729
Coexpression	GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_UP	FAM220A SLC30A4 CDPF1 PLCG2 CTSB HECTD1	2.03e-04	200	110	6	M7198
Coexpression	GSE3982_EOSINOPHIL_VS_CENT_MEMORY_CD4_TCELL_UP	NOL10 CCNH SYNJ1 NXF2 GNAQ CFAP46	2.03e-04	200	110	6	M5418
Coexpression	GSE20366_CD103_KLRG1_DP_VS_DN_TREG_DN	CCDC71L NOL10 SNX16 NIPA2 GNAQ BRWD1	2.03e-04	200	110	6	M4343
Coexpression	GSE16450_CTRL_VS_IFNA_6H_STIM_IMMATURE_NEURON_CELL_LINE_UP	ERCC5 KIF26A PPFIBP1 SLC30A4 IFIH1 SACS	2.03e-04	200	110	6	M7417
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_28\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KIF26A INSR VASH1 TTC21B EFR3B ALPL	5.06e-06	173	112	6	66488d01e03264fb193285470901c9c4182fbae8
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UBTD2 SERPINF1 CPZ SVEP1 SHC2 EFR3B	8.91e-06	191	112	6	b51e0f5d1b93f526160c904e9091313a5364f3a7
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 DENND2A RNF213 CLMN PRICKLE2 OSBPL10	1.00e-05	195	112	6	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 DENND2A RNF213 CLMN PRICKLE2 OSBPL10	1.00e-05	195	112	6	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	CEP162 INSR ZNF106 EGFR ROCK1 EBNA1BP2	1.09e-05	198	112	6	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RNF213 IFIH1 SETD2 ROCK1 PLCG2 PCM1	1.16e-05	200	112	6	12f1685ce8f218433068e090c9d839cd5a1910bf
Drug	SR-202	INSR PPARA PPARG MAPK3	1.21e-06	17	111	4	CID000060910
Drug	Ethylnitrosourea	NCKAP1 INSR PPARA EGFR TTC21B GNA11 PLCG2 GNAQ HECTD1 BRWD1	1.65e-06	291	111	10	ctd:D005038
Drug	norathyriol	PPARA PPARG MAPK3	2.23e-06	6	111	3	ctd:C069053
Drug	Ascorbic Acid	ERCC5 WARS1 GARS1 INSR FANCL PPARG EZH2 CRP EGFR SULT2A1 CDK1 MAPK3 TARS1 ALPL	2.29e-06	628	111	14	ctd:D001205
Drug	englitazone	INSR PPARA PPARG MAPK3	3.66e-06	22	111	4	CID000060303
Drug	Akt inhibitor IV	INSR PPARG EGFR MAPK3	5.27e-06	24	111	4	CID002326992
Drug	Dethiocoenzyme A	INSR PPARA EGFR PLCG2 MAPK3 MAPK4 NR1H4	7.86e-06	147	111	7	CID000003002
Drug	pyrazolo(3,4-d)pyrimidine	EGFR ROCK1 CAPN5 CDK1 PLCG2 CTSB	8.57e-06	98	111	6	ctd:C014175
Drug	myricitrin	PPARG CRP MAPK3 ALPL	8.61e-06	27	111	4	ctd:C008577
Drug	Cholesterol, Dietary	INSR PPARA PPARG MAPK3 NR1H4 ALPL	1.08e-05	102	111	6	ctd:D002791
Drug	AICA ribonucleotide	INSR PPARA PPARG EGFR MAPK3 NR1H4	1.08e-05	102	111	6	ctd:C031143
Drug	Clofibric Acid	WARS1 NCKAP1 GARS1 PPARA PPARG CRP CCNH PA2G4 ROCK1 EBNA1BP2 CTSB NR1H4 ALPL HDC	1.22e-05	727	111	14	ctd:D002995
Drug	mono-benzyl phthalate	PPARA PPARG CRP	1.32e-05	10	111	3	ctd:C103325
Drug	MCC-555	INSR PPARA PPARG MAPK3	1.52e-05	31	111	4	CID000204109
Drug	GW9662	SERPINF1 MC2R PPARA PPARG MAPK3 MAPK4 NR1H4	1.54e-05	163	111	7	CID000644213
Drug	Mevalonic Acid	PPARA PPARG CRP EGFR CDK1 MAPK3	1.75e-05	111	111	6	ctd:D008798
Drug	BE-23372M	INSR EGFR CDK1	1.81e-05	11	111	3	CID005311105
Drug	PD98059	ONECUT2 INSR PPARG SETD2 EGFR ROCK1 MAPK3 MAPK4	1.90e-05	233	111	8	CID000004713
Drug	ciprofibrate	SERPINF1 CKAP5 PPARA PPARG CRP SULT2A1 HDC	2.02e-05	170	111	7	CID000002763
Drug	oleoyl-lysophosphatidic acid	DOCK1 MYH7B PPARG EGFR ROCK1 GNA11 PLCG2 GNAQ MAPK3 MAPK4	2.20e-05	391	111	10	CID000003987
Drug	(2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid	PPARA PPARG	2.36e-05	2	111	2	DB08483
Drug	AC1L1KDK	INSR EGFR	2.36e-05	2	111	2	CID000005451
Drug	mono-n-octyl phthalate	PPARA PPARG	2.36e-05	2	111	2	ctd:C041260
Drug	LY 465608	PPARA PPARG	2.36e-05	2	111	2	ctd:C453901
Drug	MHY966	PPARA PPARG	2.36e-05	2	111	2	ctd:C580737
Drug	Gw 9544	PPARA PPARG	2.36e-05	2	111	2	CID000446642
Drug	mono-n-hexyl phthalate	PPARA PPARG	2.36e-05	2	111	2	ctd:C049841
Drug	naveglitazar	PPARA PPARG	2.36e-05	2	111	2	ctd:C517861
Drug	Phenylpropionates	PPARA PPARG	2.36e-05	2	111	2	ctd:D010666
Drug	13-oxooctadecadienoic acid	WARS1 PPARA PPARG	2.40e-05	12	111	3	CID005283012
Drug	fulvestrant	INSR PPARG EGFR CLMN CDK1 GNAQ MAPK3 CTSB TARS1 NR1H4 ALPL	2.50e-05	484	111	11	ctd:C070081
Drug	acetovanillone	EGFR PVALB GNA11 GNAQ MAPK3 ALPL	2.86e-05	121	111	6	ctd:C056165
Drug	sphingosine 1-phosphate	PPARA EGFR GNAQ MAPK3	3.12e-05	37	111	4	ctd:C060506
Drug	Clorocruoro Hem	ROCK1 CAPN5 PLCG2 MAPK3 MAPK4 CTSB	3.13e-05	123	111	6	CID003518809
Drug	isocycloheximide	INSR MC2R PPARG RGS1 SETD2 EGFR SULT2A1 CCNB3 ROCK1 CDK1 MAPK3 MAPK4 CTSB ALPL HDC	3.36e-05	905	111	15	CID000002900
Drug	Dronabinol	GIPC1 WARS1 PPFIBP1 SERPINF1 GARS1 PPARA PPARG SETD2 SCUBE1 NAPB PVALB MAST1 ABCC12 CDK1 MAPK3	3.36e-05	905	111	15	ctd:D013759
Drug	oleoylethanolamide	INSR PPARA MAPK3	3.95e-05	14	111	3	ctd:C488250
Drug	GSK126	PPARG EZH2 ALPL	3.95e-05	14	111	3	ctd:C577920
Drug	P-38	WARS1 INSR PPARA PPARG SETD2 EGFR ROCK1 PLCG2 GNAQ MAPK3 MAPK4 PCM1	4.54e-05	613	111	12	CID000200878
Drug	AC1OAGKW	INSR SYNJ1 EGFR SYNJ2 GNA11 PLCG2 MAPK3	4.55e-05	193	111	7	CID006857413
Drug	Cinchonine [118-10-5]; Up 200; 13.6uM; MCF7; HT_HG-U133A	NDST1 MC2R NOL10 PPARA SLC30A4 SYNJ1 PADI3	4.86e-05	195	111	7	4107_UP
Drug	trametinib	GNA11 GNAQ MAPK3	4.92e-05	15	111	3	ctd:C560077
Drug	AD-5075	INSR PPARA PPARG	4.92e-05	15	111	3	CID000128440
Drug	picropodophyllin	CDK1 MAPK3 NR1H4	4.92e-05	15	111	3	ctd:C415032
Drug	Sulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; MCF7; HT_HG-U133A	NCKAP1 SNX16 CDC42BPB IFIH1 SETD2 SYNJ1 PLCG2	5.02e-05	196	111	7	3422_DN
Drug	Dorzolamide hydrochloride [130693-82-2]; Up 200; 11uM; MCF7; HT_HG-U133A	SERPINF1 NOL10 H2AP EGFR SULT2A1 SYNJ2 EFR3B	5.53e-05	199	111	7	3565_UP
Drug	Uridine Triphosphate	EGFR GNAQ MAPK3	6.03e-05	16	111	3	ctd:D014544
Drug	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	PPARA PPARG MAPK3	6.03e-05	16	111	3	ctd:D019377
Drug	tyrphostin AG1296	MYH7B EGFR GNAQ MAPK3	6.25e-05	44	111	4	CID000002049
Drug	gamma-Linolenic Acid	PPARA PPARG CDK1 MAPK3	6.25e-05	44	111	4	ctd:D017965
Drug	Dehydroepiandrosterone	WARS1 PPARA EGFR SULT2A1 PLCG2 MAPK3	6.73e-05	141	111	6	ctd:D003687
Drug	AC1L1KC5	ONECUT2 EGFR SACS ROCK1 PLCG2 GNAQ MAPK3 MAPK4 CTSB FKBP1A HDC	6.84e-05	541	111	11	CID000005428
Drug	ankaflavin	PPARA NR1H4	7.04e-05	3	111	2	ctd:C499916
Drug	indeglitazar	PPARA PPARG	7.04e-05	3	111	2	CID011395145
Drug	didecyl phthalate	PPARA PPARG	7.04e-05	3	111	2	ctd:C027718
Drug	Bezafibrate	PPARA PPARG	7.04e-05	3	111	2	DB01393
Drug	linoleoyl-coenzyme A	PPARA PPARG	7.04e-05	3	111	2	ctd:C026562
Drug	2,2-dichloro-12-(p-chlorophenyl)-dodecanoic acid	PPARA PPARG	7.04e-05	3	111	2	ctd:C116893
Drug	2-methyl-c-5-(4-(5-methyl-2-(4-methylphenyl)-4-oxazolyl)butyl)-1,3-dioxane-r-2-carboxylic acid	PPARA PPARG	7.04e-05	3	111	2	ctd:C487401
Drug	oleoyl-coenzyme A	PPARA PPARG	7.04e-05	3	111	2	ctd:C017585
Drug	stearoyl-coenzyme A	PPARA PPARG	7.04e-05	3	111	2	ctd:C017725
Drug	ragaglitazar	PPARA PPARG	7.04e-05	3	111	2	ctd:C432703
Drug	5-((2,4-dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide	PPARA PPARG	7.04e-05	3	111	2	ctd:C116017
Drug	N-methylpentanamide	PPARA PPARG	7.04e-05	3	111	2	CID000022591
Drug	3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid	PPARA PPARG	7.04e-05	3	111	2	DB07724
Drug	gnetin C	PPARA PPARG	7.04e-05	3	111	2	ctd:C575740
Drug	NSC 29059	PPARA PPARG	7.04e-05	3	111	2	CID000097701
Drug	calcium silicate	EGFR MAPK3 ALPL	7.30e-05	17	111	3	ctd:C031293
Drug	monascin	PPARA PPARG NR1H4	7.30e-05	17	111	3	ctd:C517880
Drug	JTT-501	INSR PPARA PPARG	7.30e-05	17	111	3	CID000154000
Drug	Pkcs	INSR EGFR ROCK1 PLCG2 GNAQ MAPK3 MAPK4	7.99e-05	211	111	7	CID000164073
Drug	olmesartan	SERPINF1 PPARG CRP MAPK3 MAPK4	8.38e-05	91	111	5	CID000158781
Drug	purmorphamine	WARS1 PPARA PPARG	8.72e-05	18	111	3	CID005284329
Drug	RS 102221	SALL1 ROCK1 MAPK3	8.72e-05	18	111	3	CID003693566
Drug	pervanadate	INSR EGFR MAPK3	1.03e-04	19	111	3	ctd:C076715
Drug	AC1L419E	PPARA PPARG MAPK3	1.03e-04	19	111	3	CID000099951
Drug	Eicosapentaenoic Acid	PPARA PPARG CRP MAPK3 ALPL	1.08e-04	96	111	5	ctd:D015118
Drug	sildenafil	MC2R ROCK1 GNAQ MAPK3 MAPK4	1.08e-04	96	111	5	CID000005212
Drug	tetramethylpyrazine	PPARA PPARG EGFR MAPK3	1.12e-04	51	111	4	ctd:C017953
Drug	LY171883	PPARA PPARG NR1H4 ALPL	1.12e-04	51	111	4	CID000003969
Drug	NSC226080	MYH7B INSR MC2R PPARG CCNH SETD2 EGFR CCNB3 ROCK1 MAPK3 MAPK4 FKBP1A ALPL	1.13e-04	782	111	13	CID000005040
Drug	fucoxanthin	PPARA PPARG MAPK3	1.21e-04	20	111	3	ctd:C025164
Drug	pamidronate	CRP ROCK1 ALPL	1.21e-04	20	111	3	ctd:C019248
Drug	gemcabene	PPARA PPARG NR1H4	1.21e-04	20	111	3	CID000157691
Drug	hexabromocyclododecane	MC2R PPARA PPARG EGFR SULT2A1 ROCK1 MAPK3	1.33e-04	229	111	7	ctd:C089796
Drug	Y 27632	ERCC5 PPARG ROCK1 MAPK3 CTSB	1.37e-04	101	111	5	ctd:C108830
Drug	sulindac sulfone	PPARA PPARG EGFR MAPK3	1.40e-04	54	111	4	ctd:C025463
Drug	taurine	GARS1 INSR SETD2 MAPK3 MAPK4 NR1H4 ALPL	1.40e-04	231	111	7	CID000001123
Drug	rifamycin analog	PPARG NR1H4	1.40e-04	4	111	2	CID009574292
Drug	AC1MHGE4	PPARA PPARG	1.40e-04	4	111	2	CID003025998
Drug	dinonylphthalate	PPARA PPARG	1.40e-04	4	111	2	ctd:C019174
Drug	GW 2331	PPARA PPARG	1.40e-04	4	111	2	ctd:C105715
Drug	clinofibrate	PPARA PPARG	1.40e-04	4	111	2	ctd:C006231
Drug	perfluorooctanesulfonamide	PPARA PPARG	1.40e-04	4	111	2	ctd:C063900
Drug	monoethyl phthalate	PPARA PPARG	1.40e-04	4	111	2	ctd:C581825
Drug	3',4'-dihydroxy-4-monochlorobiphenyl	SULT2A1 MAPK3	1.40e-04	4	111	2	ctd:C543847
Drug	methylparaben	PPARG MAPK3 ALPL	1.41e-04	21	111	3	ctd:C015358
Drug	AGN 194204	PPARA EZH2 EGFR CDK1 MAPK3 MAPK4	1.45e-04	162	111	6	ctd:C430898
Drug	AC1L1GTT	PPARG SETD2 GNA11 GNAQ MAPK3 MAPK4 ALPL	1.48e-04	233	111	7	CID000003837
Drug	Metformin	WARS1 PPFIBP1 GARS1 INSR PPARA PPARG CRP PPP4R2 MAPK3	1.52e-04	400	111	9	ctd:D008687
Disease	Malignant neoplasm of liver	PPARA PPARG CCNH DDX54 PRICKLE2 TNK2 NR1H4	8.99e-07	142	107	7	C0345904
Disease	Liver neoplasms	PPARA PPARG CCNH DDX54 PRICKLE2 TNK2 NR1H4	8.99e-07	142	107	7	C0023903
Disease	Prostatic Neoplasms	ONECUT2 SERPINF1 MC2R PPARA EZH2 CCNH SETD2 EGFR SULT2A1 MAPK3 CTSB ZBED1	2.51e-06	616	107	12	C0033578
Disease	Malignant neoplasm of prostate	ONECUT2 SERPINF1 MC2R PPARA EZH2 CCNH SETD2 EGFR SULT2A1 MAPK3 CTSB ZBED1	2.51e-06	616	107	12	C0376358
Disease	fatty liver disease (biomarker_via_orthology)	INSR PPARA PPARG CTSB	6.17e-06	33	107	4	DOID:9452 (biomarker_via_orthology)
Disease	Phakomatosis cesioflammea	GNA11 GNAQ	1.30e-05	2	107	2	C3838883
Disease	Congenital hemangioma	GNA11 GNAQ	1.30e-05	2	107	2	C0235753
Disease	Port-wine stain with oculocutaneous melanosis	GNA11 GNAQ	1.30e-05	2	107	2	C1274879
Disease	Crohn's disease of large bowel	PPARA PPARG CRP NR1H4	1.98e-05	44	107	4	C0156147
Disease	IIeocolitis	PPARA PPARG CRP NR1H4	1.98e-05	44	107	4	C0949272
Disease	Crohn's disease of the ileum	PPARA PPARG CRP NR1H4	1.98e-05	44	107	4	C0267380
Disease	Regional enteritis	PPARA PPARG CRP NR1H4	1.98e-05	44	107	4	C0678202
Disease	Osteosarcoma	EZH2 RGS1 EGFR CCNB3	2.59e-05	47	107	4	C0029463
Disease	hepatocellular carcinoma (implicated_via_orthology)	INSR PPARA CTSB NR1H4	3.05e-05	49	107	4	DOID:684 (implicated_via_orthology)
Disease	Crohn Disease	PPARA PPARG CRP NR1H4	3.31e-05	50	107	4	C0010346
Disease	Insulin Resistance	INSR PPARA PPARG EGFR	6.82e-05	60	107	4	C0021655
Disease	Insulin Sensitivity	INSR PPARA PPARG EGFR	6.82e-05	60	107	4	C0920563
Disease	retinal vein occlusion (is_marker_for)	SERPINF1 CRP	7.78e-05	4	107	2	DOID:1727 (is_marker_for)
Disease	amino acid metabolic disorder (implicated_via_orthology)	TARS3 TARS1	7.78e-05	4	107	2	DOID:9252 (implicated_via_orthology)
Disease	hepatocellular carcinoma (is_marker_for)	SERPINF1 INSR PPARG EZH2 EGFR CDK1 NR1H4	1.17e-04	301	107	7	DOID:684 (is_marker_for)
Disease	Malignant melanoma of iris	GNA11 GNAQ	1.29e-04	5	107	2	C0346373
Disease	Malignant melanoma of choroid	GNA11 GNAQ	1.29e-04	5	107	2	C0346388
Disease	Hyperparathyroidism, Secondary	CRP ALPL	1.29e-04	5	107	2	C0020503
Disease	kidney failure (is_marker_for)	SERPINF1 CRP	1.94e-04	6	107	2	DOID:1074 (is_marker_for)
Disease	proliferative diabetic retinopathy (is_implicated_in)	SERPINF1 PPARG	1.94e-04	6	107	2	DOID:13207 (is_implicated_in)
Disease	early-onset Parkinson's disease (implicated_via_orthology)	SYNJ1 SYNJ2	1.94e-04	6	107	2	DOID:0060894 (implicated_via_orthology)
Disease	obesity (biomarker_via_orthology)	SERPINF1 PPARA PPARG CRP NR1H4	2.03e-04	147	107	5	DOID:9970 (biomarker_via_orthology)
Disease	Giant Cell Glioblastoma	PPARG CCNH EGFR CTSB	2.52e-04	84	107	4	C0334588
Disease	Uveal melanoma	GNA11 GNAQ	3.60e-04	8	107	2	C0220633
Disease	Cutaneous Melanoma	ERCC5 GNA11 GNAQ	4.47e-04	41	107	3	C0151779
Disease	alcoholic liver cirrhosis (is_marker_for)	SERPINF1 CRP	4.61e-04	9	107	2	DOID:14018 (is_marker_for)
Disease	Acute Confusional Senile Dementia	INSR PPARG SLC30A4 PLCG2	4.72e-04	99	107	4	C0546126
Disease	Alzheimer's Disease, Focal Onset	INSR PPARG SLC30A4 PLCG2	4.72e-04	99	107	4	C0750900
Disease	Alzheimer Disease, Early Onset	INSR PPARG SLC30A4 PLCG2	4.72e-04	99	107	4	C0750901
Disease	Presenile dementia	INSR PPARG SLC30A4 PLCG2	4.72e-04	99	107	4	C0011265
Disease	Alzheimer Disease, Late Onset	INSR PPARG SLC30A4 PLCG2	4.72e-04	99	107	4	C0494463
Disease	calcium measurement	ERCC5 PPARG CNNM3 GNA11 ABCC12 GNAQ ASCC3 L3MBTL3 ALPL	4.77e-04	628	107	9	EFO_0004838
Disease	mean arterial pressure	WARS1 INSR RNF213 SVEP1 EDEM3 EFR3B GNA11 MAPK4	4.78e-04	499	107	8	EFO_0006340
Disease	Familial Alzheimer Disease (FAD)	INSR PPARG SLC30A4 PLCG2	4.90e-04	100	107	4	C0276496
Disease	Alzheimer's Disease	INSR PPARG SLC30A4 PLCG2	5.09e-04	101	107	4	C0002395
Disease	Malignant Head and Neck Neoplasm	FANCL EGFR MAPK3	5.51e-04	44	107	3	C0278996
Disease	high grade glioma (implicated_via_orthology)	INSR EGFR CTSB	5.51e-04	44	107	3	DOID:3070 (implicated_via_orthology)
Disease	Metabolic Diseases	PPARG CRP	5.75e-04	10	107	2	C0025517
Disease	renal Wilms' tumor (is_implicated_in)	EZH2 SALL1	5.75e-04	10	107	2	DOID:5176 (is_implicated_in)
Disease	breast cancer (is_marker_for)	INSR CRP EGFR CDK1 CTSB	5.82e-04	185	107	5	DOID:1612 (is_marker_for)
Disease	cerebral cavernous malformation (implicated_via_orthology)	RNF213 CDC42BPB	7.01e-04	11	107	2	DOID:0060669 (implicated_via_orthology)
Disease	response to fenofibrate	SLC30A4 SCUBE1 DDX54	8.03e-04	50	107	3	GO_1901557
Disease	diabetic retinopathy (is_marker_for)	SERPINF1 CRP EGFR	1.01e-03	54	107	3	DOID:8947 (is_marker_for)
Disease	Hepatomegaly	PPARA NR1H4 HDC	1.01e-03	54	107	3	C0019209
Disease	malignant pleural mesothelioma (is_marker_for)	EZH2 SETD2	1.15e-03	14	107	2	DOID:7474 (is_marker_for)
Disease	Psoriasis	PPARG CRP IFIH1	1.18e-03	57	107	3	C0033860
Disease	Pustulosis of Palms and Soles	PPARG CRP IFIH1	1.18e-03	57	107	3	C0030246
Disease	Inflammation	PPARA PPARG CRP NR1H4	1.20e-03	127	107	4	C0021368
Disease	Atherosclerosis	PPARG CRP NR1H4	1.30e-03	59	107	3	C0004153
Disease	Atherogenesis	PPARG CRP NR1H4	1.30e-03	59	107	3	C1563937
Disease	Down syndrome (implicated_via_orthology)	SYNJ1 SYNJ2	1.33e-03	15	107	2	DOID:14250 (implicated_via_orthology)
Disease	Hypertriglyceridemia	PPARA CRP	1.33e-03	15	107	2	C0020557
Disease	osteosarcoma (is_implicated_in)	SERPINF1 EZH2	1.51e-03	16	107	2	DOID:3347 (is_implicated_in)
Disease	gliosarcoma	PPARG EGFR	1.51e-03	16	107	2	C0206726
Disease	Monogenic diabetes	INSR PPARG	1.51e-03	16	107	2	C3888631
Disease	transitional cell carcinoma (is_marker_for)	EGFR CDK1 CTSB	1.57e-03	63	107	3	DOID:2671 (is_marker_for)
Disease	fatty liver disease (is_marker_for)	PPARA ALPL	1.71e-03	17	107	2	DOID:9452 (is_marker_for)
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	INSR EZH2 NR1H4	1.72e-03	65	107	3	DOID:0080208 (biomarker_via_orthology)
Disease	platelet component distribution width	CCDC71L DENND2A PPARG SVEP1 SETD2 EGFR SYNJ2 PLCG2 BRWD1	1.73e-03	755	107	9	EFO_0007984
Disease	Parkinson's disease (is_marker_for)	SERPINF1 CRP EGFR	1.88e-03	67	107	3	DOID:14330 (is_marker_for)
Disease	alcoholic hepatitis (biomarker_via_orthology)	PPARA NR1H4	1.92e-03	18	107	2	DOID:12351 (biomarker_via_orthology)
Disease	non-alcoholic steatohepatitis (is_marker_for)	SERPINF1 NR1H4	1.92e-03	18	107	2	DOID:0080547 (is_marker_for)
Disease	inflammatory bowel disease (is_implicated_in)	CRP EGFR	2.14e-03	19	107	2	DOID:0050589 (is_implicated_in)
Disease	DiGeorge syndrome (implicated_via_orthology)	DOCK1 NDST1	2.14e-03	19	107	2	DOID:11198 (implicated_via_orthology)
Disease	free androgen index	INSR PPARA PPARG SETD2 L3MBTL3 NR1H4	2.46e-03	374	107	6	EFO_0007005
Disease	Parkinson's disease (implicated_via_orthology)	GIPC1 INSR SYNJ1 SYNJ2	2.60e-03	157	107	4	DOID:14330 (implicated_via_orthology)
Disease	colorectal cancer (is_marker_for)	SERPINF1 EZH2 SETD2 EGFR	2.60e-03	157	107	4	DOID:9256 (is_marker_for)
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	CKAP5 PLCG2	2.62e-03	21	107	2	EFO_0004286, EFO_0004792
Disease	complement factor H-like 1 protein measurement	FAM220A SYNJ2	2.87e-03	22	107	2	EFO_0600092
Disease	portal hypertension (biomarker_via_orthology)	SERPINF1 VASH1	2.87e-03	22	107	2	DOID:10762 (biomarker_via_orthology)
Disease	Glioblastoma	CCNH EGFR CTSB	3.00e-03	79	107	3	C0017636
Disease	goiter	INSR SALL1	3.14e-03	23	107	2	EFO_0004283
Disease	liver cirrhosis (is_marker_for)	VASH1 CRP EGFR	3.34e-03	82	107	3	DOID:5082 (is_marker_for)
Disease	lung non-small cell carcinoma (is_marker_for)	SERPINF1 EZH2 EGFR GNAQ	3.39e-03	169	107	4	DOID:3908 (is_marker_for)
Disease	Cancer of Head	EGFR MAPK3	3.41e-03	24	107	2	C0751177
Disease	Dyslipidemias	PPARA PPARG	3.41e-03	24	107	2	C0242339
Disease	Head Neoplasms	EGFR MAPK3	3.41e-03	24	107	2	C0018675
Disease	Dyslipoproteinemias	PPARA PPARG	3.41e-03	24	107	2	C0598784
Disease	Upper Aerodigestive Tract Neoplasms	EGFR MAPK3	3.41e-03	24	107	2	C0887900

Protein segments in the cluster

Peptide	Gene	Start	Entry
AKPDELMDSKLRCVF	VAPA	116	Q9P0L0
KLEDVPRFFSMAEKR	TTC21B	1001	Q7Z4L5
EKRLLEFCSVFKPAM	CCNH	61	P51946
ELKDRETFKAAQMFP	ANKRD30B	701	Q9BXX2
RVMFTEDLKLPASFD	CTSB	71	P07858
EETKRIFLDRLKPMF	FAM220A	206	Q7Z4H9
RFPSISEEKMLLLFE	CFAP46	281	Q8IYW2
TFTLKLTEPRKAFDM	GIPC1	206	O14908
SAEFLLRIFLKMPDS	CAPN13	466	Q6MZZ7
MKDPFTSDKDRFLVL	CDPF1	46	Q6NVV7
FFKSEKLDMIRLRNP	CAPN5	271	O15484
KFDSSRDRNKPFKFM	FKBP1A	36	P62942
MSKVFSGKRLEAEFP	TNK2	76	Q07912
LLPFKMKSTTEEKFL	CCNB3	621	Q8WWL7
PRFLKSDMYKALLAE	RGS11	406	O94810
LMEKDSYPRFLKSDI	RGS1	181	Q08116
REFILKMFVDLNPDS	GNAQ	306	P50148
SAEFKEKLDMSRFPV	GUF1	51	Q8N442
AMFLRSAEIFNKKLP	NR1H4	341	Q96RI1
TVFSEKTGMPFRLKD	L3MBTL3	96	Q96JM7
MPFTLRAFEDEKKAR	PA2G4	276	Q9UQ80
VKMKFLPVDDNFSLR	HDC	206	P19113
KLPMTFFTELEKTTL	nan	831	O00370
DVTRFLFDEMPKSRK	H2AP	101	O75409
LKEDDMFKDFAARSP	PPFIBP1	986	Q86W92
IDFLEKILTFNPMDR	MAPK4	286	P31152
DTDDIKIPMLFLFSK	EDEM3	756	Q9BZQ6
KTACFLLPMFERLKT	DDX54	146	Q8TDD1
KRPTDYFAEMAKSDL	EBNA1BP2	131	Q99848
RKFPSDKIFEAISSM	EZH2	216	Q15910
LFFKMKPLLRSAQAE	MYH7B	881	A7E2Y1
SERLPDEKVELFSKM	PCM1	386	Q15154
FATPKMLVDFFIERK	OR4K1	76	Q8NGD4
FATPKMIADFLREHK	OR4K3	76	Q96R72
MEKLTFYALSAPEKL	EFR3B	36	Q9Y2G0
SRFKDMPNFIALEKS	EBLN2	166	Q6P2I7
LFAIFKENKRPSKEM	ONECUT2	441	O95948
LASLPVSFRKDEKAM	NIPA2	306	Q8N8Q9
KYPEMDLDSRAFLKD	NDST1	836	P52848
RSAEAMSFLKVDPRK	KIF26A	386	Q9ULI4
FPKSDSKALDLLDRM	MAPK3	296	P27361
EDFRDLSFPKLIMIT	INSR	71	P06213
KFIDDTMRETAEPFL	PLCG2	271	P16885
SKFEDKLPEDMARFY	CDC42BPB	166	Q9Y5S2
LPNILTDDRFKVMFE	NOL10	476	Q9BSC4
ERKKATAFFPDLVNM	PADI3	576	Q9ULW8
RTSFDKPDQMAALFK	NCKAP1	881	Q9Y2A7
FPKATAQMEEKLRDF	MAST1	186	Q9Y2H9
RLEMDKFPFVALSKT	ALPL	86	P05186
PLEMEKTISKLMFDF	PRICKLE2	6	Q7Z3G6
FRELIIEFSKMARDP	EGFR	961	P00533
RMFFEDEKPALLSQI	CKAP5	791	Q14008
RDGFNKVFPMEKLSS	HECTD1	2466	Q9ULT8
PDEKMFKLLSRAYAD	CPZ	406	Q66K79
VFDPKELSKMFTEFI	DOCK1	811	Q14185
PLKLERSFKFMREAE	DENND2A	591	Q9ULE3
REFILKMFVDLNPDS	GNA11	306	P29992
PLKLDETDRFLMTLF	IFIH1	666	Q9BYX4
DMSRKAFVFPKESDT	CRP	21	P02741
SFELIPFKAALRSKM	DNAAF9	411	Q5TEA3
ERKETEFFSSLPLKM	CEP162	376	Q5TB80
DLSSEEERFMKPKVT	BRWD1	416	Q9NSI6
DSTKALGDAFKLFMP	CCDC71L	51	Q8N9Z2
DKEEPRSFFFMSEKA	FAM172BP	86	A6NC97
EREKVIDFSKPFMTL	GRIK4	506	Q16099
AQESKEMFPRSFIKL	SCUBE1	961	Q8IWY4
VKFPEMFQKDLAARS	SALL1	1211	Q9NSC2
DSIKRLEMEKSSDFP	SACS	511	Q9NZJ4
FKLEKVMDDFRTSAP	PPP4R2	51	Q9NY27
REFLKSLRKPFCDIM	PPARA	341	Q07869
FEDSRNMKTLKDPYL	NXF2	441	Q9GZY0
FTFEIEKDTFALKPM	TARS3	476	A2RTX5
MFSFEVEKELFALKP	TARS1	396	P26639
IVKEFMTPRKLSFDF	WARS1	456	P23381
NEDFIEIARKLSFPM	SYNJ1	701	O43426
SKPIVDRFVESFKAM	SYNJ2	416	O15056
DFPARAILEKSDFTM	FANCL	291	Q9NW38
IMSDSPSAKEVFKER	NBEAL2	391	Q6ZNJ1
MTREFLKSLRKPFGD	PPARG	376	P37231
FPISDESMIKDRKDR	ERCC5	486	P28715
EFMPFVKELSEALTR	GARS1	626	P41250
LFPAFSDSRECKLMK	NAPA	231	P54920
FDKLFQEKMADLPRE	SULT2A1	266	Q06520
SELMFVRKLLSDFPV	SVEP1	101	Q4LDE5
DTVFDKILKSPMSFF	ABCC12	886	Q96J65
MADDPSKSYKLRFVA	OSBPL10	516	Q9BXB5
FKDPSDRVMKLITSD	SNAPC1	161	Q16533
PELRDAFKKMIFCSR	MC2R	281	Q01718
EFLSMDLKKYLDSIP	CDK1	81	P06493
MFKDRLKPECSTEEL	ASCC3	1831	Q8N3C0
FVCDKPESMKEFRLD	CLMN	351	Q96JQ2
QKELEFMFKFTRREP	CLEC2L	141	P0C7M8
ASLMAPLKRKEEFSL	CNNM3	466	Q8NE01
MLETSFGFPLSKDLK	NLRP9	506	Q7RTR0
LFKLDPSVDFSAFMK	RNF213	1476	Q63HN8
IDGKMRPSESFLLEF	VPS35L	761	Q7Z3J2
EMKLQSLFDSPDFSK	SERPINF1	331	P36955
KDLFDMRPFEDALKL	SHC2	431	P98077
MFSRFLPEKTDLKDY	THEM5	41	Q8N1Q8
FSPDARDLSAKETKM	PVALB	71	P20472
FSGRPLTDKMKFEEL	UBTD2	196	Q8WUN7
VMLSFPLFKDDLCKD	TSTD2	226	Q5T7W7
MFPAFTDSRECKLLK	NAPB	231	Q9H115
MSAFASEPRKRDKLE	RPAP1	296	Q9BWH6
TEADTDTPKKLMFRR	SETD2	1866	Q9BYW2
LLSKFEMIKRSDSAF	ROCK1	106	Q13464
MLTLRLSFFDVDSKP	USP41	191	Q3LFD5
KSMLRKDDAPLFLND	SLC30A4	11	O14863
MEPLKFRDVAIEFSL	ZNF681	1	Q96N22
MREAFATAFSKLKPE	ZBED1	86	O96006
TDFSRLNDKLKEMFP	SNX16	146	P57768
FFEIKKSRPLTGLMD	VASH1	141	Q7L8A9
MSRNDKEPFFVKFLK	TOPBP1	1	Q92547
KSEMIEKPLFDFSLI	ZNF106	371	Q9H2Y7
KDIRLERSMKEFFAP	LRRIQ3	396	A6PVS8