Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium:bicarbonate symporter activity	SLC4A8 SLC4A4	1.23e-04	6	58	2	GO:0008510
GeneOntologyMolecularFunction	ligase activity, forming phosphoric ester bonds	LIG4 RTCB	1.73e-04	7	58	2	GO:0016886
GeneOntologyBiologicalProcess	regulation of organelle organization	LIG4 FCHSD2 VPS13D CDC42EP4 TBC1D22A SPTBN1 SYNE2 PDE4DIP BUB1B TOGARAM2 FLCN HUWE1 KIF20B SLX4 GSN	3.05e-06	1342	58	15	GO:0033043
Domain	Actinin_actin-bd_CS	DST SPTBN1 SYNE2 PLEC	6.61e-07	23	57	4	IPR001589
Domain	ACTININ_2	DST SPTBN1 SYNE2 PLEC	6.61e-07	23	57	4	PS00020
Domain	ACTININ_1	DST SPTBN1 SYNE2 PLEC	6.61e-07	23	57	4	PS00019
Domain	Spectrin_repeat	DST SPTBN1 SYNE2 PLEC	1.75e-06	29	57	4	IPR002017
Domain	Spectrin/alpha-actinin	DST SPTBN1 SYNE2 PLEC	2.63e-06	32	57	4	IPR018159
Domain	SPEC	DST SPTBN1 SYNE2 PLEC	2.63e-06	32	57	4	SM00150
Domain	Spectrin	DST SPTBN1 SYNE2	4.57e-05	23	57	3	PF00435
Domain	CH	DST SPTBN1 SYNE2 PLEC	4.59e-05	65	57	4	SM00033
Domain	CH	DST SPTBN1 SYNE2 PLEC	6.15e-05	70	57	4	PF00307
Domain	-	DST SPTBN1 SYNE2 PLEC	6.50e-05	71	57	4	1.10.418.10
Domain	CH	DST SPTBN1 SYNE2 PLEC	7.25e-05	73	57	4	PS50021
Domain	CH-domain	DST SPTBN1 SYNE2 PLEC	8.06e-05	75	57	4	IPR001715
Domain	Na/HCO3_transpt	SLC4A8 SLC4A4	9.10e-05	5	57	2	IPR003024
Domain	-	DST PLEC	1.36e-04	6	57	2	3.90.1290.10
Domain	Plectin_repeat	DST PLEC	1.90e-04	7	57	2	IPR001101
Domain	Plectin	DST PLEC	1.90e-04	7	57	2	PF00681
Domain	PLEC	DST PLEC	1.90e-04	7	57	2	SM00250
Domain	Band3_cytoplasmic_dom	SLC4A8 SLC4A4	3.25e-04	9	57	2	IPR013769
Domain	Band_3_cyto	SLC4A8 SLC4A4	3.25e-04	9	57	2	PF07565
Domain	-	SLC4A8 SLC4A4	3.25e-04	9	57	2	3.40.1100.10
Domain	HCO3_cotransp	SLC4A8 SLC4A4	4.05e-04	10	57	2	PF00955
Domain	HCO3_transpt_C	SLC4A8 SLC4A4	4.05e-04	10	57	2	IPR011531
Domain	PTrfase/Anion_transptr	SLC4A8 SLC4A4	4.05e-04	10	57	2	IPR016152
Domain	HCO3_transpt_euk	SLC4A8 SLC4A4	4.05e-04	10	57	2	IPR003020
Domain	WWE	HUWE1 PARP12	5.92e-04	12	57	2	PS50918
Domain	WWE	HUWE1 PARP12	5.92e-04	12	57	2	PF02825
Domain	WWE-dom	HUWE1 PARP12	5.92e-04	12	57	2	IPR004170
Domain	UBA-like	VPS13D USP25 HUWE1	9.84e-04	64	57	3	IPR009060
Domain	UIM	USP25 HUWE1	2.42e-03	24	57	2	PS50330
Domain	UIM_dom	USP25 HUWE1	2.62e-03	25	57	2	IPR003903
Domain	-	ZCCHC18 ZCCHC7	2.84e-03	26	57	2	4.10.60.10
Domain	HECT	HUWE1 HERC1	3.06e-03	27	57	2	PF00632
Domain	HECTc	HUWE1 HERC1	3.06e-03	27	57	2	SM00119
Domain	HECT_dom	HUWE1 HERC1	3.06e-03	27	57	2	IPR000569
Domain	HECT	HUWE1 HERC1	3.06e-03	27	57	2	PS50237
Domain	UBA	VPS13D HUWE1	3.77e-03	30	57	2	SM00165
Domain	ZF_CCHC	ZCCHC18 ZCCHC7	5.10e-03	35	57	2	PS50158
Domain	UBA	VPS13D HUWE1	5.39e-03	36	57	2	PF00627
Pathway	REACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY	DST PLEC	2.65e-04	9	39	2	MM15117
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A8 SLC4A4	3.31e-04	10	39	2	M27335
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A8 SLC4A4	3.31e-04	10	39	2	MM15073
Pathway	REACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY	DST PLEC	4.04e-04	11	39	2	M27372
Pathway	REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS	PLEC GSN	4.84e-04	12	39	2	MM14908
Pathway	REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS	PLEC GSN	4.84e-04	12	39	2	M3634
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	IVNS1ABP BNIP2 DST RASGRF2 SPTBN1 SYNE2 PDE4DIP PLEC MED13	1.79e-07	497	60	9	23414517
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	UBE4A EMC3 DST RTCB HACD3 SPTBN1 SYNE2 BUB1B HUWE1 IFIT1 GSN PARP12 IPO11	8.37e-07	1440	60	13	30833792
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	IVNS1ABP VPS13D DST CDC42EP4 RTCB CEP112 SPTBN1 SYNE2 BUB1B PLEC	2.02e-06	861	60	10	36931259
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	MESD EMC3 SLC4A8 HCN4 HACD3 SPTBN1 PDE4DIP BSDC1 PLEC HUWE1 SLC4A4	3.49e-06	1139	60	11	36417873
Pubmed	Functional proteomics mapping of a human signaling pathway.	DST SPTBN1 PDE4DIP USP25 PLEC HUWE1 ZCCHC7 HERC1	7.80e-06	591	60	8	15231748
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	VPS13D RTCB SPTBN1 SYNE2 PLEC HERC1	8.44e-06	277	60	6	30745168
Pubmed	BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin.	DST PLEC	8.77e-06	3	60	2	19932097
Pubmed	Several genetic variants associated with systemic sclerosis in a Chinese Han population.	CXCR5 ARID3A	8.77e-06	3	60	2	36301368
Pubmed	Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.	DST PLEC	1.75e-05	4	60	2	14668477
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	VPS13D EMC3 DST TBC1D22A SYNE2 FLCN VPS16	2.56e-05	504	60	7	34432599
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SLC4A8 DST HCN4 SPTBN1 SYNE2 PDE4DIP HUWE1 SLC4A4 GSN	3.84e-05	963	60	9	28671696
Pubmed	Analysis of erythrocyte and platelet membrane proteins in various forms of beta-thalassemia.	SPTBN1 GSN	4.37e-05	6	60	2	15310273
Pubmed	TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.	SYNE2 PLEC	4.37e-05	6	60	2	18827015
Pubmed	Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.	CEP112 ADAMTS14	6.11e-05	7	60	2	19851299
Pubmed	The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.	DST PLEC	6.11e-05	7	60	2	10637308
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	UBE4A DST SPTBN1 PDE4DIP USP25 ZNF202 PLEC HUWE1 SLX4 MED13	6.42e-05	1285	60	10	35914814
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	VPS13D HACD3 SPTBN1 PLEC GSN	6.63e-05	245	60	5	21182205
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	EMC3 RTCB TM9SF4 PDE4DIP VPS16 HUWE1 HERC1 SLC4A4 IPO11	8.09e-05	1061	60	9	33845483
Pubmed	Epidermolysis Bullosa Simplex	DST PLEC	8.14e-05	8	60	2	20301543
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MESD CEP112 SPTBN1 PLEC HUWE1 HERC1 DNA2 SLX4 PARP12	9.52e-05	1084	60	9	11544199
Pubmed	Proteomic analysis of the NOS2 interactome in human airway epithelial cells.	HACD3 PLEC HUWE1 HERC1	9.74e-05	138	60	4	23438482
Pubmed	Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.	DST PLEC	1.05e-04	9	60	2	12482924
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	DST RTCB SPTBN1 HUWE1 HERC1	1.07e-04	271	60	5	25737280
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	CEP112 SPTBN1 VPS16 PLEC MED13	1.08e-04	272	60	5	31010829
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	MESD DST HACD3 ZC3H15 BUB1B HUWE1 MED13	1.20e-04	645	60	7	25281560
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	RASGRF2 SPTBN1 PLEC GSN	1.24e-04	147	60	4	16959763
Pubmed	Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.	TBC1D22A VPS16 HUWE1	1.27e-04	56	60	3	27103069
Pubmed	USP7 controls NGN3 stability and pancreatic endocrine lineage development.	SPTBN1 PLEC HUWE1	1.41e-04	58	60	3	37117185
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	SPTBN1 PDE4DIP VPS16 GSN	1.56e-04	156	60	4	29961565
Pubmed	Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11.	HUWE1 IPO11	1.59e-04	11	60	2	11809816
Pubmed	The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.	DST PLEC	1.59e-04	11	60	2	10811835
Pubmed	Current insights into the formation and breakdown of hemidesmosomes.	DST PLEC	1.59e-04	11	60	2	16757171
Pubmed	Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.	DST PLEC	1.59e-04	11	60	2	12802069
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	IVNS1ABP BNIP2 RTCB SPTBN1 BUB1B USP25 PLEC HUWE1 HERC1 IPO11	1.78e-04	1455	60	10	22863883
Pubmed	EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.	DST PDE4DIP PLEC	1.80e-04	63	60	3	29162697
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	DST USP25 PLEC HUWE1 HERC1 SLX4	1.81e-04	481	60	6	28190767
Pubmed	Meta-analysis identifies six new susceptibility loci for atrial fibrillation.	HCN4 SYNE2	1.91e-04	12	60	2	22544366
Pubmed	p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes.	SYNE2 PLEC	1.91e-04	12	60	2	28595999
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	VPS13D RASGRF2 SPTBN1 TOGARAM2 HERC1 IPO11	2.15e-04	497	60	6	36774506
Pubmed	Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.	IVNS1ABP RTCB HACD3 HUWE1 MED13	2.21e-04	317	60	5	11042152
Pubmed	Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.	DST PLEC	2.26e-04	13	60	2	22962592
Pubmed	Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.	DST PLEC	2.26e-04	13	60	2	9670011
Pubmed	The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.	HACD3 TM9SF4 SPTBN1 HUWE1 IFIT1	2.48e-04	325	60	5	36168628
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	CCDC9B DST CEP112 SPTBN1 PARP12	2.62e-04	329	60	5	34316702
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CCDC9B DST RTCB HACD3 ZC3H15 SPTBN1 PLEC KIF20B GSN	2.88e-04	1257	60	9	36526897
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	CEP112 CNPY4 PDE4DIP USP25 DNA2 GSN IPO11	3.12e-04	754	60	7	33060197
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	EMC3 DST RTCB HACD3 SYNE2 PLEC HUWE1 GSN	3.62e-04	1024	60	8	24711643
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	DST RTCB SPTBN1 PLEC GSN	3.96e-04	360	60	5	33111431
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	UBE4A DST PDE4DIP PLEC GSN	4.11e-04	363	60	5	14691545
Pubmed	Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.	SYNE2 HUWE1 SLX4	4.36e-04	85	60	3	19596235
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	VPS13D DST ZC3H15 SPTBN1 SYNE2 BSDC1	4.38e-04	568	60	6	37774976
Pubmed	A genome-wide association study of sleep habits and insomnia.	ADAMTS14 NAALADL2	4.40e-04	18	60	2	23728906
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TM9SF4 SYNE2 HUWE1	4.67e-04	87	60	3	12465718
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	DST RTCB HACD3 SPTBN1 PLEC HUWE1 GSN	4.68e-04	807	60	7	30575818
Pubmed	Quantitative analysis of PPT1 interactome in human neuroblastoma cells.	RTCB SPTBN1 PLEC HUWE1	4.83e-04	210	60	4	26217791
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DST RTCB HACD3 SPTBN1 VPS16 PLEC HUWE1 KIF20B PARP12	4.92e-04	1353	60	9	29467282
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	RTCB ZC3H15 TM9SF4 SPTBN1 SYNE2 HUWE1 IFIT1 GSN IPO11	5.29e-04	1367	60	9	32687490
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	DST SYNE2 HUWE1	5.50e-04	92	60	3	15840729
Pubmed	Proteome analysis of the circadian clock protein PERIOD2.	PLEC GSN CRY1	5.85e-04	94	60	3	35122331
Pubmed	Prohibitin regulates TGF-beta induced apoptosis as a downstream effector of Smad-dependent and -independent signaling.	PLEC IPO11	6.02e-04	21	60	2	19725029
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	EMC3 RTCB HACD3 ZC3H15 SPTBN1 SYNE2 PLEC HUWE1 GSN	6.78e-04	1415	60	9	28515276
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	IVNS1ABP HACD3 TM9SF4 SPTBN1 HUWE1	6.97e-04	408	60	5	33766124
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	PTPN5 DST SPTBN1 USP25 HUWE1 GSN	6.99e-04	621	60	6	22794259
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FCHSD2 SLC4A8 DST	7.21e-04	101	60	3	9872452
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	SPTBN1 PLEC HUWE1 IFIT1	7.36e-04	235	60	4	28378594
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	FCHSD2 VPS13D SPTBN1 PLEC	7.36e-04	235	60	4	30258100
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	DST BUB1B PLEC HUWE1 KIF20B	7.77e-04	418	60	5	34709266
Pubmed	Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.	IVNS1ABP RTCB HACD3 ERI3 PLEC	7.77e-04	418	60	5	32552912
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	EMC3 RTCB HACD3 TBC1D22A CNPY4 PLEC ADAMTS14 IFIT1 PARP12	8.10e-04	1451	60	9	30550785
Pubmed	NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.	SPTBN1 PLEC	8.56e-04	25	60	2	30309841
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	IVNS1ABP ZC3H15 HERC1 CRY1	8.60e-04	245	60	4	35652658
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	AVEN HACD3 SPTBN1 HUWE1	8.73e-04	246	60	4	15345747
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DST RTCB SPTBN1 SYNE2 PLEC HUWE1	9.07e-04	653	60	6	22586326
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HUWE1 HERC1	9.26e-04	26	60	2	26949039
Pubmed	Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.	CEP112 ADAMTS14	9.26e-04	26	60	2	20378664
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	FCHSD2 DST PDE4DIP	9.48e-04	111	60	3	22558309
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	UBE4A VPS13D EMC3 DST HACD3 SYNE2 HUWE1 HERC1 IFIT1	1.01e-03	1496	60	9	32877691
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	USP25 VPS16 DNA2 PARP12	1.03e-03	257	60	4	30945288
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	UBE4A EMC3 HACD3 TM9SF4 SPTBN1 PLEC ZCCHC7 SLX4	1.04e-03	1203	60	8	29180619
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	UBE4A EMC3 HACD3 BSDC1 HUWE1	1.07e-03	449	60	5	31732153
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	UBE4A KIF20B PARP12	1.08e-03	116	60	3	21282530
Pubmed	Global landscape of HIV-human protein complexes.	IVNS1ABP MESD HACD3 FLCN HUWE1	1.16e-03	457	60	5	22190034
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	DST SPTBN1 PDE4DIP	1.19e-03	120	60	3	31413325
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	RTCB HACD3 PLEC IPO11	1.21e-03	269	60	4	29511261
Pubmed	Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.	SPTBN1 BUB1B VPS16	1.22e-03	121	60	3	26354767
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	MESD EMC3 CDC42EP4 HACD3 TM9SF4 BSDC1 SLC4A4	1.23e-03	952	60	7	38569033
Pubmed	The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.	SPTBN1 SYNE2	1.23e-03	30	60	2	30480076
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	DST SPTBN1 PLEC HUWE1 GSN	1.40e-03	477	60	5	31300519
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	UBE4A DST SPTBN1 PLEC	1.48e-03	284	60	4	29459677
Pubmed	Reevaluating human gene annotation: a second-generation analysis of chromosome 22.	RTCB TBC1D22A	1.49e-03	33	60	2	12529303
Pubmed	Lynch Syndrome	BUB1B FLCN	1.49e-03	33	60	2	20301390
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	VPS13D DST MED13	1.49e-03	130	60	3	12421765
Pubmed	Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.	DST HACD3 PLEC GSN	1.50e-03	285	60	4	21423176
Pubmed	A human MAP kinase interactome.	DST CDC42EP4 SPTBN1 PLEC SLC4A4	1.52e-03	486	60	5	20936779
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	RTCB HACD3 ZC3H15 HUWE1 DNA2	1.52e-03	486	60	5	30940648
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	ARID3A RTCB GSN	1.53e-03	131	60	3	34551306
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	DST HCN4 SPTBN1 PDE4DIP BSDC1 PLEC ZCCHC7 MED13	1.64e-03	1293	60	8	15342556
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	IVNS1ABP MESD DST RTCB CEP112 ZC3H15 TM9SF4 SYNE2	1.67e-03	1297	60	8	33545068
Pubmed	Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.	RTCB SPTBN1 PLEC GSN	1.70e-03	295	60	4	26209609
Interaction	YWHAH interactions	IVNS1ABP VPS13D DST CDC42EP4 RTCB CEP112 SPTBN1 SYNE2 FLCN PLEC HUWE1 HERC1 CRY1	1.15e-05	1102	58	13	int:YWHAH
Cytoband	11q23.3	CXCR5 UBE4A ZNF202	1.51e-04	78	60	3	11q23.3
Cytoband	15q22.2	BNIP2 HACD3	6.67e-04	29	60	2	15q22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr15q22	BNIP2 HACD3 HERC1	7.05e-04	132	60	3	chr15q22
Cytoband	10q23.31	IFIT1 KIF20B	9.17e-04	34	60	2	10q23.31
GeneFamily	EF-hand domain containing\|Plakins	DST PLEC	1.26e-04	8	39	2	939
GeneFamily	Zinc fingers CCHC-type\|RNA binding motif containing	ZCCHC18 ZCCHC7	1.32e-03	25	39	2	74
GeneFamily	Zinc fingers CCCH-type	ZC3H15 PARP12	2.58e-03	35	39	2	73
Coexpression	GSE21670_IL6_VS_TGFB_AND_IL6_TREATED_STAT3_KO_CD4_TCELL_DN	CXCR5 MESD RASGRF2 SPTBN1 BSDC1 IFIT1	6.32e-06	199	60	6	M7451
Coexpression	GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP	IVNS1ABP CXCR5 DST CEP112 USP25 FLCN PLEC IFIT1 PARP12	1.05e-05	616	60	9	MM977
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP	CXCR5 CEP112 USP25 PLEC IFIT1 PARP12	1.63e-05	235	60	6	MM978
Coexpression	GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP	IVNS1ABP CXCR5 DST CEP112 USP25 FLCN PLEC PARP12	4.34e-05	567	60	8	M1097
Coexpression	HELLER_HDAC_TARGETS_UP	SLC4A8 PDE4DIP PLEC HERC1 IFIT1 GSN	8.63e-05	317	60	6	M3335
Coexpression	GSE3982_MEMORY_CD4_TCELL_VS_TH2_UP	SYNE2 USP25 HUWE1 HERC1 GSN	8.69e-05	196	60	5	M5381
Coexpression	GSE39556_UNTREATED_VS_3H_POLYIC_INJ_MOUSE_NK_CELL_UP	FCHSD2 SYNE2 BUB1B DNA2 KIF20B	9.34e-05	199	60	5	M9410
Coexpression	HALLMARK_MITOTIC_SPINDLE	DST CDC42EP4 SPTBN1 KIF20B GSN	9.34e-05	199	60	5	M5893
Coexpression	GSE33162_UNTREATED_VS_4H_LPS_STIM_HDAC3_HET_MACROPHAGE_DN	CXCR5 CEP112 SPTBN1 HUWE1 HERC1	9.34e-05	199	60	5	M9031
Coexpression	GSE27786_BCELL_VS_CD8_TCELL_UP	CXCR5 LIG4 FCHSD2 BUB1B MED13	9.56e-05	200	60	5	M4801
Coexpression	GSE25123_WT_VS_PPARG_KO_MACROPHAGE_ROSIGLITAZONE_STIM_UP	FCHSD2 VPS13D DST ARID3A HACD3	9.56e-05	200	60	5	M7978
Coexpression	GSE21670_TGFB_VS_IL6_TREATED_STAT3_KO_CD4_TCELL_DN	RASGRF2 SYNE2 IFIT1 GSN PARP12	9.56e-05	200	60	5	M7432
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP	CXCR5 CEP112 USP25 PLEC PARP12	1.43e-04	218	60	5	M1099
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	FCHSD2 TBC1D22A USP25 ZCCHC7 HERC1 NAALADL2	2.85e-07	199	60	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	SYNE2 HUWE1 HERC1 MED13 CRY1	5.47e-06	188	60	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	Mild/Remission-B_activate-7\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	FCHSD2 USP25 ZCCHC7 IFIT1 PARP12	5.91e-06	191	60	5	382686d62f7b8576c44bb9726a4e10dc26fd348e
ToppCell	Mild/Remission-B_activate-7\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	FCHSD2 USP25 ZCCHC7 IFIT1 PARP12	6.38e-06	194	60	5	01c97543972159a9468272da06e7e611e2c21fae
ToppCell	B_cells-ISG-high_B_cells\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	RTCB USP25 IFIT1 GSN PARP12	6.54e-06	195	60	5	b64d9e1a8834401b4dc501566546647754ae21fc
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	DST RASGRF2 SPTBN1 SYNE2 IFIT1	7.39e-06	200	60	5	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN5 CCDC9B PTPRQ TOGARAM2	6.28e-05	159	60	4	4000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN5 CCDC9B PTPRQ TOGARAM2	6.28e-05	159	60	4	7619d0d49738dd08daf01b42664691a5323aa793
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR5 ARID3A RASGRF2 ZCCHC7	6.59e-05	161	60	4	249c2b97cc25de5053f5048ee354615df49b2081
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	FCHSD2 VPS13D DST PLEC	6.59e-05	161	60	4	347edb0de10850b7d16c40945751033289289c9b
ToppCell	PND01-03-samps\|World / Age Group, Lineage, Cell class and subclass	CCDC9B SPTBN1 PLEC GSN	6.59e-05	161	60	4	1973b112d8d67aacc02751797d0148e7b53bfa66
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IVNS1ABP BNIP2 DST SYNE2	7.42e-05	166	60	4	7a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IVNS1ABP BNIP2 DST SYNE2	7.42e-05	166	60	4	bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CEP112 WDR87 BUB1B KIF20B	7.95e-05	169	60	4	563c267edaade0e5df192ad953801ef9768d4270
ToppCell	RSV-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	TOGARAM2 IFIT1 SLX4 GSN	9.10e-05	175	60	4	ff3a27f512a3a710ebc863b7b75cce8167d5440b
ToppCell	RSV-Healthy-1\|RSV / Virus stimulation, Condition and Cluster	TOGARAM2 IFIT1 SLX4 GSN	9.10e-05	175	60	4	ca52b99b03535a5b3a2751d6981708dc5b255b91
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	FCHSD2 VPS13D DST HERC1	9.51e-05	177	60	4	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST HCN4 PDE4DIP HERC1	9.72e-05	178	60	4	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	IVNS1ABP RASGRF2 SPTBN1 SYNE2	1.01e-04	180	60	4	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	COVID-19_Mild-Lymphoid_T/NK-CD4+_T_activated\|COVID-19_Mild / Disease group, lineage and cell class	RASGRF2 SPTBN1 SYNE2 IFIT1	1.08e-04	183	60	4	7717fce227b4e02ed41baad8ae7dd2e22bd7c13e
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	DST SYNE2 IFIT1 PARP12	1.08e-04	183	60	4	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	B_cells-ISG-high_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	FCHSD2 RTCB IFIT1 PARP12	1.08e-04	183	60	4	dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CXCR5 ARID3A BUB1B KIF20B	1.10e-04	184	60	4	8f40093de5bb978f046d66e8f05f333686a009a4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DST PTPRQ PDE4DIP TOGARAM2	1.13e-04	185	60	4	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DST PTPRQ PDE4DIP TOGARAM2	1.13e-04	185	60	4	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DST PTPRQ PDE4DIP TOGARAM2	1.13e-04	185	60	4	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	COVID-CD4-CD8_1\|COVID / Condition, Cell_class and T cell subcluster	LIG4 FCHSD2 RASGRF2 BUB1B	1.13e-04	185	60	4	c634bb04a081ae3214b68f6e4a147db5b2b916ed
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DST PTPRQ PDE4DIP ADAMTS14	1.17e-04	187	60	4	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	COVID-19-Heart-EC_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PTPN5 RASGRF2 SPTBN1 SYNE2	1.22e-04	189	60	4	fe49852ba15f948b384d6b4c258927c70b741357
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CEP112 BUB1B DNA2 KIF20B	1.25e-04	190	60	4	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	IVNS1ABP SYNE2 HERC1 CRY1	1.30e-04	192	60	4	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IVNS1ABP SLC4A8 SYNE2 PDE4DIP	1.30e-04	192	60	4	ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCell	Control-Lymphoid-Proliferating_CD4_T_cells\|Control / Condition, Lineage and Cell class	SPTBN1 BUB1B DNA2 KIF20B	1.33e-04	193	60	4	33d409d6ed1c606337248587ad997ac5f67f081d
ToppCell	human_hepatoblastoma-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CEP112 BUB1B DNA2 KIF20B	1.33e-04	193	60	4	4b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	CEP112 SPTBN1 SYNE2 CFAP46	1.38e-04	195	60	4	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	CEP112 SPTBN1 SYNE2 CFAP46	1.38e-04	195	60	4	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST HUWE1 ZCCHC7 HERC1	1.38e-04	195	60	4	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	DST SPTBN1 SYNE2 PDE4DIP	1.38e-04	195	60	4	22191d361af136942508f1553ff41a626ed982ad
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST HUWE1 ZCCHC7 HERC1	1.38e-04	195	60	4	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	SYNE2 HERC1 IFIT1 PARP12	1.46e-04	198	60	4	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IVNS1ABP DST SPTBN1 HUWE1	1.46e-04	198	60	4	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	VPS13D EMC3 SYNE2 KIF20B	1.46e-04	198	60	4	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IVNS1ABP DST SPTBN1 HUWE1	1.46e-04	198	60	4	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_T_activated\|Control / Disease, condition lineage and cell class	RASGRF2 SPTBN1 SYNE2 IFIT1	1.46e-04	198	60	4	ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IVNS1ABP DST SPTBN1 HUWE1	1.49e-04	199	60	4	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DST SPTBN1 PLEC GSN	1.49e-04	199	60	4	9b02acae6325b0ac9642438a4431285ff396e5fe
ToppCell	COVID-19_Moderate\|World / disease group, cell group and cell class	SPTBN1 SYNE2 IFIT1 PARP12	1.49e-04	199	60	4	952fac67588ad5676f5939e3c7f8bac803c27064
ToppCell	18-Distal-Mesenchymal-Mesenchyme_RSPO2+\|Distal / Age, Tissue, Lineage and Cell class	DST CDC42EP4 HACD3 IFIT1	1.49e-04	199	60	4	95403988caef322314f4ed15415ad1a9a987adc1
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST SPTBN1 SYNE2 IFIT1	1.52e-04	200	60	4	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	Hematolymphoid-Endothelial-NOSTRIN\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	RASGRF2 CEP112 SPTBN1 SYNE2	1.52e-04	200	60	4	032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST SPTBN1 SYNE2 IFIT1	1.52e-04	200	60	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	mLN-T_cell-cycling_gd_T\|mLN / Region, Cell class and subclass	BUB1B ADAMTS14 SLC4A4 CFAP46	1.52e-04	200	60	4	4efeef51f885ee8f6dd3911a536cc49e3c14da98
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST SPTBN1 SYNE2 IFIT1	1.52e-04	200	60	4	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	Hematolymphoid-Endothelial-NOSTRIN---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	RASGRF2 CEP112 SPTBN1 SYNE2	1.52e-04	200	60	4	68fce28690246895fd33354b30960ebcc31aa4cc
ToppCell	LPS_only-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	DST SPTBN1 SYNE2 IFIT1	1.52e-04	200	60	4	81e76508c9050d533853d5fd2f3097b27613d836
ToppCell	mLN-(1)_T_cell-(18)_cycling_gd_T\|mLN / shred on region, Cell_type, and subtype	BUB1B ADAMTS14 SLC4A4 CFAP46	1.52e-04	200	60	4	e8a0a88a8344e80783931115bbe6cd5b62a4c1f7
ToppCell	Control_saline-Endothelial-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	DST SPTBN1 PLEC IFIT1	1.52e-04	200	60	4	e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCell	Hematolymphoid-Endothelial-NOSTRIN-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	RASGRF2 CEP112 SPTBN1 SYNE2	1.52e-04	200	60	4	376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST SPTBN1 SYNE2 IFIT1	1.52e-04	200	60	4	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DST SPTBN1 SYNE2 IFIT1	1.52e-04	200	60	4	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	IVNS1ABP SYNE2 HUWE1 IFIT1	1.52e-04	200	60	4	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Hematolymphoid-Endothelial-NOSTRIN--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	RASGRF2 CEP112 SPTBN1 SYNE2	1.52e-04	200	60	4	7fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCell	Control_saline-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	DST SPTBN1 PLEC IFIT1	1.52e-04	200	60	4	3372c488a39fe812fa94e4f0564594186fea3db5
ToppCell	Hematolymphoid-Endothelial-NOSTRIN----L2-6\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	RASGRF2 CEP112 SPTBN1 SYNE2	1.52e-04	200	60	4	878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCell	Hematolymphoid-Endothelial\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	RASGRF2 CEP112 SPTBN1 SYNE2	1.52e-04	200	60	4	7136936d05ab344a560cf159684c881063b5430d
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	DST SPTBN1 SYNE2 IFIT1	1.52e-04	200	60	4	4bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Neuronal-GABAergic_neurons\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	DST TBC1D22A PDE4DIP	2.28e-04	88	60	3	5582fd7bac60c690ecd1f2aff1d446ccb69f79b9
Disease	Weight Gain	VPS13D SPTBN1 GSN IPO11	5.29e-05	102	59	4	C0043094
Disease	epidermolysis bullosa simplex (is_implicated_in)	DST PLEC	8.20e-05	7	59	2	DOID:4644 (is_implicated_in)
Disease	response to ketamine, dissociation measurement	RASGRF2 TOGARAM2	3.02e-04	13	59	2	EFO_0009748, EFO_0009750
Disease	anemia (implicated_via_orthology)	SLC4A8 SLC4A4	4.06e-04	15	59	2	DOID:2355 (implicated_via_orthology)
Disease	Seckel syndrome	LIG4 DNA2	8.85e-04	22	59	2	C0265202
Disease	Colorectal cancer	BUB1B FLCN	1.34e-03	27	59	2	cv:C0346629
Disease	COLORECTAL CANCER	BUB1B FLCN	1.34e-03	27	59	2	114500
Disease	Neoplasm of the large intestine	BUB1B FLCN	1.34e-03	27	59	2	cv:C0009404
Disease	level of Sphingomyelin (d38:1) in blood serum	SYNE2 SLC4A4	1.65e-03	30	59	2	OBA_2045180
Disease	colorectal cancer (is_implicated_in)	LIG4 BUB1B FLCN	1.85e-03	121	59	3	DOID:9256 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSEAMSLEGDEWELS	BUB1B	11	O60566
LERVDEWMAKEGLLD	ERI3	221	O43414
VHEAWAGMLKEEDDD	CNPY4	16	Q8N129
TLEMDLENLEDLFWE	CXCR5	6	P32302
ISEDWEKDFDLDMTE	BSDC1	391	Q9NW68
MEVGSEEEKWEKLDA	CEP112	1	Q8N8E3
TEEEDKEWRAELMLE	CFAP46	166	Q8IYW2
MGLEWEDAVEDAKES	ADAMTS14	781	Q8WXS8
WMEEKIEDDFLDLDP	PTPN5	196	P54829
MEKLADLEEESESWD	FLCN	286	Q8NFG4
DFDRWLDESDAEMEL	HACD3	106	Q9P035
IWENGDSLEELMEEV	IVNS1ABP	206	Q9Y6Y0
LMEWLEESEKSLDSE	DST	6716	Q03001
ADMARLLEQWEKDDD	MESD	61	Q14696
LTEEELTMWEEDPEG	IPO11	376	Q9UI26
DWDMLDVDEDEKLTG	HERC1	3076	Q15751
WDMKEDKEELEGQEG	CCDC9B	341	Q6ZUT6
EESFESWLEDAKDML	PNMA6F	266	A0A0J9YX94
SWENSLEDLMEDEDL	KIF20B	521	Q96Q89
ETLDELGWMDEESKK	MMEL1	481	Q495T6
LWDMLGECLKELEES	HUWE1	3856	Q7Z6Z7
AKAWIMDEEEDAEEE	HCN4	21	Q9Y3Q4
LDAMEGDVELEWEET	PTPRQ	2316	Q9UMZ3
RGKWEDLDNMELIEE	PARP12	306	Q9H0J9
DDKEWHECMTLDDLE	LIG4	586	P49917
KNVTEEELEDWLDSM	AVEN	346	Q9NQS1
EGMKVFEELLLDADW	CRY1	376	Q16526
VLSIMDKEEWDPEEG	CDC42EP4	221	Q9H3Q1
MEGVELKEEWQDEDF	BNIP2	1	Q12982
FTWELSIDDDEMPDL	IFIT1	21	P09914
EAEWMALTALEEGED	C2orf81	41	A6NN90
EDLATDDVMLLDTWD	GSN	691	P06396
QWALDDVEEELMAKD	EMC3	231	Q9P0I2
LEVIEDGDMEDWVKA	FCHSD2	496	O94868
ELELLMEKSFWEEAE	DNA2	6	P51530
QEVMKGRELEELEWD	CYP4F22	366	Q6NT55
KDLEEALEMGVDWSL	RTCB	166	Q9Y3I0
EAWLQEVEELMDEDL	SYNE2	396	Q8WXH0
LTLGSPEWEEEEEMD	TOGARAM2	461	Q6ZUX3
LELRCEEEQDGKEWM	RASGRF2	111	O14827
DEICMKEGEDAEWKE	SLC4A8	121	Q2Y0W8
EEKQEDMDWEDDSLA	MED13	251	Q9UHV7
SMWADEEEEAETLLK	SLX4	821	Q8IY92
ADADDIDAWMLDILK	SPTBN1	751	Q01082
KWEEEEMEEDLGEDE	ARID3A	126	Q99856
DDIEDTMEESGWKLV	TM9SF4	316	Q92544
ELYSMDWDLKEELRD	VPS16	21	Q9H269
LDWLEDAFQMKAEEE	USP25	271	Q9UHP3
LMWLNEKEEEEVGFD	PLEC	766	Q15149
AWDAGEDDDELLAMA	TBC1D22A	71	Q8WUA7
ELIKMIREEEDWDDA	ZCCHC18	211	P0CG32
WMLLGCEVDDKDDDI	ZCCHC7	176	Q8N3Z6
ELDELLAVDGQEMEW	SLC4A4	111	Q9Y6R1
LEEMAVELEDQDWLD	UBE4A	116	Q14139
RDEELEKDTMDNWDE	ZC3H15	141	Q8WU90
EKELAQELEELEWDM	WDR87	1711	Q6ZQQ6
LEWDMEELSWKEEEL	WDR87	1721	Q6ZQQ6
DLWEEEGILMVKLED	ZNF202	11	O95125
DDKDIESAKSEDWMG	VPS13D	2826	Q5THJ4
LDLEWDMEKELEESG	NAALADL2	46	Q58DX5
AMSDGWEIEEDKEKG	PDE4DIP	1066	Q5VU43