Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glycogen phosphorylase activity	PYGB PYGL PYGM	7.57e-07	3	183	3	GO:0008184
GeneOntologyMolecularFunction	1,4-alpha-oligoglucan phosphorylase activity	PYGB PYGL PYGM	7.47e-06	5	183	3	GO:0004645
GeneOntologyMolecularFunction	GTPase activator activity	TAGAP MYO9B SIPA1L3 ARHGEF12 ARHGEF11 RAB3GAP1 RGS20 NF1 RASAL3 SIPA1L2 ARAP1	5.55e-05	279	183	11	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	GBF1 TAGAP MYO9B SIPA1L3 ARHGEF12 ARHGEF11 DENND4C RAB3GAP1 RGS20 NF1 RASAL3 RIMS1 ARHGEF4 SIPA1L2 ARAP1	7.05e-05	507	183	15	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	GBF1 TAGAP MYO9B SIPA1L3 ARHGEF12 ARHGEF11 DENND4C RAB3GAP1 RGS20 NF1 RASAL3 RIMS1 ARHGEF4 SIPA1L2 ARAP1	7.05e-05	507	183	15	GO:0030695
GeneOntologyMolecularFunction	bile acid binding	AKR1C2 AKR1C3 PYGL	8.67e-05	10	183	3	GO:0032052
GeneOntologyMolecularFunction	androsterone dehydrogenase (B-specific) activity	AKR1C2 AKR1C3	4.95e-04	4	183	2	GO:0047042
GeneOntologyMolecularFunction	ketoreductase activity	AKR1C2 AKR1C3	4.95e-04	4	183	2	GO:0045703
GeneOntologyMolecularFunction	chlordecone reductase activity	AKR1C2 AKR1C3	4.95e-04	4	183	2	GO:0047743
GeneOntologyMolecularFunction	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C2 AKR1C3	8.20e-04	5	183	2	GO:0047115
GeneOntologyMolecularFunction	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	AKR1C2 AKR1C3	8.20e-04	5	183	2	GO:0047020
GeneOntologyMolecularFunction	17-beta-ketosteroid reductase (NADPH) activity	AKR1C2 AKR1C3	8.20e-04	5	183	2	GO:0072555
GeneOntologyMolecularFunction	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	AKR1C2 AKR1C3	8.20e-04	5	183	2	GO:0047006
GeneOntologyMolecularFunction	lithocholic acid binding	AKR1C2 AKR1C3	8.20e-04	5	183	2	GO:1902121
GeneOntologyMolecularFunction	ketosteroid monooxygenase activity	AKR1C2 AKR1C3	8.20e-04	5	183	2	GO:0047086
GeneOntologyMolecularFunction	Delta4-3-oxosteroid 5beta-reductase activity	AKR1C2 AKR1C3	8.20e-04	5	183	2	GO:0047787
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1C2 AKR1C3	1.22e-03	6	183	2	GO:0045550
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	GBF1 TAGAP MYO9B SIPA1L3 ARHGEF12 ARHGEF11 DENND4C NF1 RASAL3 ARHGEF4 SIPA1L2 NOTCH2 ARAP1	9.17e-06	333	183	13	GO:0051056
MousePheno	abnormal vocalization	MPL ACHE TSPYL1 AKR1C2 SSUH2 SAMD9L NALF1 MTM1 CNTNAP2 AKR1C3 UTP20 NUP153 MVD ARAP1	3.28e-07	237	153	14	MP:0001529
Domain	PHOSPHORYLASE	PYGB PYGL PYGM	8.95e-07	3	181	3	PS00102
Domain	Glycg_phsphrylas	PYGB PYGL PYGM	8.95e-07	3	181	3	IPR011833
Domain	Glyco_trans_35	PYGB PYGL PYGM	8.95e-07	3	181	3	IPR000811
Domain	Phosphorylase	PYGB PYGL PYGM	8.95e-07	3	181	3	PF00343
Domain	C2	C2CD4B C2CD4A SYT2 NEDD4 RASAL3 HECW2 C2CD4D CAPN5 RIMS1 SMURF2	1.25e-06	142	181	10	PS50004
Domain	C2_dom	C2CD4B C2CD4A SYT2 NEDD4 RASAL3 HECW2 C2CD4D CAPN5 RIMS1 SMURF2	4.61e-06	164	181	10	IPR000008
Domain	-	C2CD4B SYT2 NEDD4 RASAL3 HECW2 C2CD4D CAPN5 RIMS1 SMURF2	1.43e-05	148	181	9	2.60.40.150
Domain	PDZ	DVL1P1 SIPA1L3 DVL1 ARHGEF12 PDZD7 ARHGEF11 RIMS1 SIPA1L2	7.05e-05	141	181	8	PF00595
Domain	DVL-1	DVL1P1 DVL1	9.34e-05	2	181	2	IPR008340
Domain	PDZ	DVL1P1 SIPA1L3 DVL1 ARHGEF12 PDZD7 ARHGEF11 RIMS1 SIPA1L2	9.90e-05	148	181	8	SM00228
Domain	PDZ	DVL1P1 SIPA1L3 DVL1 ARHGEF12 PDZD7 ARHGEF11 RIMS1 SIPA1L2	1.14e-04	151	181	8	PS50106
Domain	PDZ	DVL1P1 SIPA1L3 DVL1 ARHGEF12 PDZD7 ARHGEF11 RIMS1 SIPA1L2	1.19e-04	152	181	8	IPR001478
Domain	RGS-like_dom	ARHGEF12 ARHGEF11	2.78e-04	3	181	2	IPR015212
Domain	SPAR_C	SIPA1L3 SIPA1L2	2.78e-04	3	181	2	PF11881
Domain	RGS-like	ARHGEF12 ARHGEF11	2.78e-04	3	181	2	PF09128
Domain	SIPA1L_C	SIPA1L3 SIPA1L2	2.78e-04	3	181	2	IPR021818
Domain	C2	SYT2 NEDD4 HECW2 C2CD4D CAPN5 RIMS1 SMURF2	2.91e-04	131	181	7	PF00168
Domain	C2	SYT2 NEDD4 HECW2 C2CD4D CAPN5 RIMS1 SMURF2	3.82e-04	137	181	7	SM00239
Domain	Dishevelled	DVL1P1 DVL1	5.53e-04	4	181	2	PF02377
Domain	Dishevelled_fam	DVL1P1 DVL1	5.53e-04	4	181	2	IPR008339
Domain	Dishevelled_protein_dom	DVL1P1 DVL1	5.53e-04	4	181	2	IPR003351
Domain	-	SIPA1L3 DVL1 ARHGEF12 PDZD7 ARHGEF11 RIMS1 SIPA1L2	6.57e-04	150	181	7	2.30.42.10
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOGEN_DEGRADATION	G6PC3 PYGB PYGL PYGM	8.39e-07	9	130	4	M47621
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA3F RNF223 GBF1 MYO9B PIEZO1 SIPA1L3 DVL1 LMTK2 AMBRA1 EML2 PTCH1 ARHGEF11 STK11IP RNF43 WDR59 ANO8 C6orf132 FANCA PPP1R26 DIP2A INTS5 KANSL1 TRIB3 USP40 CPSF1 PYGB DISP2 ARHGEF4 SIPA1L2 SMURF2 SOWAHB NOTCH2 ARAP1	2.18e-15	1105	191	33	35748872
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	HGH1 DYNC2H1 FKRP TTI2 TSPYL1 ATP9A TARS2 NSUN2 RNF43 SACM1L FANCA RAB3GAP1 INTS5 RNF5 ASPH UTP20 LSS TIMELESS CORO7 NUP153 RAVER1	6.37e-08	942	191	21	31073040
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	PRRG2 IRS4 GBF1 BCAR1 MAGEE1 PTCH1 PRR7 C6orf132 NEDD4 RASAL3 NUP153 ARAP1 FAM110B	8.59e-07	430	191	13	35044719
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	GBF1 HDAC6 KDM5A PHRF1 NSUN2 TRIM16 INTS5 NF1 KANSL1 ASPH CPSF1 UTP20 TIMELESS RIMS1 NUP153 NOTCH2 RAVER1	1.50e-06	774	191	17	15302935
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	IRS4 GBF1 CAMKK1 KDM5A SIPA1L3 LMTK2 BCAR1 WDR59 DENND4C C6orf132 NEDD4 NF1 ARHGEF4 RASSF8 SIPA1L2 NOTCH2 FAM110B	6.15e-06	861	191	17	36931259
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	IRS4 GBF1 HDAC6 LRCH2 CAMKK1 SIPA1L3 TSPYL1 DENND4C NF1 RASSF8 SIPA1L2 NOTCH2	7.48e-06	446	191	12	24255178
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	IRS4 POLD2 TARS2 RAB3GAP1 DROSHA ARMC5 EPC1 SIPA1L2 RAVER1	8.46e-06	242	191	9	34011540
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	KDM5A DCLRE1B NSUN2 WDR59 SACM1L TRIM16 MST1 TRMU RAB3GAP1 NF1 TRIB3 ARMC5 EPC1 CHEK2 CPSF1 FIBP LSS SMPD1 SLC23A1 SOWAHB CDK6	1.45e-05	1327	191	21	32694731
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	AMBRA1 TARS2 NSUN2 SACM1L FANCA CLPTM1L DIP2A DROSHA ARMC5 ASPH PYGB TIMELESS DBR1 RAVER1	1.61e-05	650	191	14	38777146
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FNIP2 LRCH2 ARHGEF12 ATP9A SACM1L NEDD4 LRIG3 KANSL1 DISP2 ARHGEF4 SIPA1L2	1.73e-05	407	191	11	12693553
Pubmed	Characterising the dynamics of placental glycogen stores in the mouse.	G6PC3 PYGB PYGL PYGM	1.88e-05	29	191	4	32798765
Pubmed	Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.	PTCH1 NEDD4 SMURF2	1.90e-05	10	191	3	25092867
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	GBF1 POLD2 TARS2 STK11IP GFER SIRT3 DENND4C SACM1L CLPTM1L EBP ASPH CPSF1 METTL17 NOTCH2	2.91e-05	686	191	14	28380382
Pubmed	Semaphorin 3B and 3F single nucleotide polymorphisms are associated with prostate cancer risk and poor prognosis.	SEMA3F SEMA3B	3.00e-05	2	191	2	19683737
Pubmed	Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.	ARHGEF12 ARHGEF11	3.00e-05	2	191	2	24106280
Pubmed	The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.	SLC2A9 SLC2A6	3.00e-05	2	191	2	17997608
Pubmed	Substrate clustering potently regulates the activity of WW-HECT domain-containing ubiquitin ligases.	NEDD4 SMURF2	3.00e-05	2	191	2	29463679
Pubmed	Mammalian class theta GST and differential susceptibility to carcinogens: a review.	GSTT2B GSTT2	3.00e-05	2	191	2	11018744
Pubmed	Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1.	GSTT2B GSTT2	3.00e-05	2	191	2	8617493
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	3.00e-05	2	191	2	8644734
Pubmed	Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes.	SLC2A9 SLC2A6	3.00e-05	2	191	2	10970791
Pubmed	Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22.	GSTT2B GSTT2	3.00e-05	2	191	2	7789971
Pubmed	C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population.	C2CD4B C2CD4A	3.00e-05	2	191	2	35212842
Pubmed	Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.	C2CD4B C2CD4A	3.00e-05	2	191	2	33492421
Pubmed	Gene structure, expression and chromosomal localization of murine theta class glutathione transferase mGSTT1-1.	GSTT2B GSTT2	3.00e-05	2	191	2	9854036
Pubmed	Local androgen inactivation in abdominal visceral adipose tissue.	AKR1C2 AKR1C3	3.00e-05	2	191	2	14671194
Pubmed	Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow-Derived Macrophage Function.	SLC2A9 SLC2A6	3.00e-05	2	191	2	30700586
Pubmed	A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.	C2CD4B C2CD4A	3.00e-05	2	191	2	29625024
Pubmed	AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants.	AKR1C2 AKR1C3	3.00e-05	2	191	2	33675863
Pubmed	Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns.	SEMA3F SEMA3B	3.00e-05	2	191	2	8633026
Pubmed	Association between GLUT9 and gout in Japanese men.	SLC2A9 SLC2A6	3.00e-05	2	191	2	20413573
Pubmed	Identification and characterization of GSTT3, a third murine Theta class glutathione transferase.	GSTT2B GSTT2	3.00e-05	2	191	2	12038961
Pubmed	Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes.	GSTT2B GSTT2	3.00e-05	2	191	2	19424424
Pubmed	The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis.	GNE RNF5	3.00e-05	2	191	2	18270596
Pubmed	KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential.	PPP1R26 UTP20	3.00e-05	2	191	2	16053918
Pubmed	Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes.	PYGB PYGM	3.00e-05	2	191	2	25130497
Pubmed	Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate.	GSTT2B GSTT2	3.00e-05	2	191	2	1417752
Pubmed	Hormonal regulation and distinct functions of semaphorin-3B and semaphorin-3F in ovarian cancer.	SEMA3F SEMA3B	3.00e-05	2	191	2	20124444
Pubmed	Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development.	C2CD4B C2CD4A C2CD4D	3.46e-05	12	191	3	27349930
Pubmed	Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.	C2CD4B C2CD4A ARAP1	3.46e-05	12	191	3	21873549
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SEMA3F FKRP PIEZO1 ATP9A SACM1L FANCA IGSF10 EDEM3 CLPTM1L NF1 EBP ASPH SEMA3B CPSF1 TTI1 UTP20 SMPD1 TIMELESS NOTCH2	3.82e-05	1201	191	19	35696571
Pubmed	Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.	TARS2 SIRT3 TRMU	4.48e-05	13	191	3	19209188
Pubmed	Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages.	PTCH1 AKR1C2 AKR1C3	5.68e-05	14	191	3	19955443
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	GLT6D1 SLC2A9 ARHGEF12 ARHGEF11 SIRT3 FANCA PYGB TTI1 PYGL	6.36e-05	313	191	9	20800603
Pubmed	Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively.	PYGB PYGL PYGM	7.07e-05	15	191	3	2575583
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TREX1 GBF1 DYNC2H1 FKRP TARS2 STK11IP SIRT3 TRIM16 LRIG3 INTS5 NF1 SLC2A6 EBP TTI1 LSS TIMELESS NOTCH2	8.50e-05	1061	191	17	33845483
Pubmed	Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.	AKR1C2 AKR1C3	8.97e-05	3	191	2	19320734
Pubmed	Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells.	ARHGEF12 ARHGEF11	8.97e-05	3	191	2	15143072
Pubmed	Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.	AKR1C2 AKR1C3	8.97e-05	3	191	2	31780644
Pubmed	No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse.	SLC2A9 SLC2A6	8.97e-05	3	191	2	25565311
Pubmed	NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation.	HGH1 NSUN2	8.97e-05	3	191	2	38844963
Pubmed	c-Ski, Smurf2, and Arkadia as regulators of TGF-beta signaling: new targets for managing myofibroblast function and cardiac fibrosis.	SMURF2 RNF111	8.97e-05	3	191	2	19898560
Pubmed	Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.	AKR1C2 AKR1C3	8.97e-05	3	191	2	13678667
Pubmed	Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).	ARHGEF12 ARHGEF11	8.97e-05	3	191	2	21454492
Pubmed	Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors.	ARHGEF12 ARHGEF11	8.97e-05	3	191	2	12220504
Pubmed	Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9.	PTCH1 NEDD4	8.97e-05	3	191	2	22679284
Pubmed	Reversible regulation of SATB1 ubiquitination by USP47 and SMURF2 mediates colon cancer cell proliferation and tumor progression.	SATB1 SMURF2	8.97e-05	3	191	2	30742943
Pubmed	Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control.	CHEK2 TIMELESS	8.97e-05	3	191	2	19996108
Pubmed	Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF.	ARHGEF12 ARHGEF11	8.97e-05	3	191	2	26627240
Pubmed	A novel gene family induced by acute inflammation in endothelial cells.	C2CD4B C2CD4A	8.97e-05	3	191	2	15527968
Pubmed	RapGAPs in brain: multipurpose players in neuronal Rap signalling.	SIPA1L3 SIPA1L2	8.97e-05	3	191	2	20576033
Pubmed	Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.	PTCH1 SMURF2	8.97e-05	3	191	2	24925320
Pubmed	A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.	C2CD4B C2CD4A	8.97e-05	3	191	2	20818381
Pubmed	A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese.	C2CD4B C2CD4A	8.97e-05	3	191	2	21799836
Pubmed	Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.	AKR1C2 AKR1C3	8.97e-05	3	191	2	21232532
Pubmed	Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.	C2CD4B C2CD4A	8.97e-05	3	191	2	27329800
Pubmed	HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway.	ARHGEF12 ARHGEF11	8.97e-05	3	191	2	20844236
Pubmed	The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human.	GSTT2B GSTT2	8.97e-05	3	191	2	8761485
Pubmed	B plexins activate Rho through PDZ-RhoGEF.	ARHGEF12 ARHGEF11	8.97e-05	3	191	2	12372594
Pubmed	Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts.	DVL1 NEDD4	8.97e-05	3	191	2	22467858
Pubmed	Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation.	GSTT2B GSTT2	8.97e-05	3	191	2	30783009
Pubmed	MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation.	SATB1 CDK6	8.97e-05	3	191	2	22683624
Pubmed	Specific variants in WDR35 cause a distinctive form of Ellis-van Creveld syndrome by disrupting the recruitment of the EvC complex and SMO into the cilium.	DYNC2H1 WDR35	8.97e-05	3	191	2	25908617
Pubmed	AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells.	AKR1C2 AKR1C3	8.97e-05	3	191	2	18508192
Pubmed	Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.	MYO9B PIEZO1 TMEM79	1.05e-04	17	191	3	24647736
Pubmed	Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination.	AOC1 ARHGEF11 PAPPA CORO7	1.31e-04	47	191	4	26687681
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	ATP9A NSUN2 ANO8 CLPTM1L G6PC3 SLC2A6 EPC1 ASPH RETREG1 TTI1 LSS NUP153 NOTCH2	1.38e-04	697	191	13	28298427
Pubmed	Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.	RNF43 HSF5 NALF1	1.48e-04	19	191	3	25208829
Pubmed	SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.	NEDD4 HECW2 SMURF2	1.48e-04	19	191	3	21572392
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	DNAH10 PDZD7 BCAR1 NSUN2 LRIG3 INTS5 LSS SPINDOC	1.58e-04	277	191	8	30745168
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	LRCH2 SIPA1L3 ARHGEF12 DENND4C MISP RASSF8 SIPA1L2	1.66e-04	209	191	7	36779422
Pubmed	WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland.	PTCH1 AKR1C2 AKR1C3	1.74e-04	20	191	3	24135228
Pubmed	Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).	AKR1C2 AKR1C3	1.79e-04	4	191	2	10500239
Pubmed	AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.	AKR1C2 AKR1C3	1.79e-04	4	191	2	19487289
Pubmed	Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C2 AKR1C3	1.79e-04	4	191	2	14967952
Pubmed	Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.	AKR1C2 AKR1C3	1.79e-04	4	191	2	10393440
Pubmed	Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.	AKR1C2 AKR1C3	1.79e-04	4	191	2	15193432
Pubmed	Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.	AKR1C2 AKR1C3	1.79e-04	4	191	2	31479646
Pubmed	Variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A are associated with intermediate Charcot-Marie-Tooth disease in a Norwegian family.	DNAH10 LRIG3	1.79e-04	4	191	2	26517670
Pubmed	Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.	AKR1C2 AKR1C3	1.79e-04	4	191	2	16191478
Pubmed	Pathways of adipose tissue androgen metabolism in women: depot differences and modulation by adipogenesis.	AKR1C2 AKR1C3	1.79e-04	4	191	2	18984855
Pubmed	Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.	AKR1C2 AKR1C3	1.79e-04	4	191	2	15577209
Pubmed	Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.	AKR1C2 AKR1C3	1.79e-04	4	191	2	10702227
Pubmed	Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.	AKR1C2 AKR1C3	1.79e-04	4	191	2	17034817
Pubmed	RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.	AKR1C2 AKR1C3	1.79e-04	4	191	2	29764944
Pubmed	Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases.	DVL1 RNF43	1.79e-04	4	191	2	25891077
Pubmed	Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.	AKR1C2 AKR1C3	1.79e-04	4	191	2	17888864
Pubmed	Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.	AKR1C2 AKR1C3	1.79e-04	4	191	2	17442338
Pubmed	Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.	AKR1C2 AKR1C3	1.79e-04	4	191	2	28329705
Pubmed	Clinical significance of Gata-1, Gata-2, EKLF, and c-MPL expression in acute myeloid leukemia.	MPL KLF1	1.79e-04	4	191	2	19097174
Interaction	TOP3B interactions	SEMA3F RNF223 GBF1 MYO9B PIEZO1 SIPA1L3 DVL1 LMTK2 AMBRA1 EML2 PTCH1 ARHGEF11 STK11IP RNF43 WDR59 ANO8 C6orf132 FANCA PPP1R26 DIP2A INTS5 KANSL1 TRIB3 USP40 CPSF1 PYGB DISP2 ARHGEF4 SIPA1L2 SMURF2 SOWAHB NOTCH2 ARAP1	2.10e-06	1470	188	33	int:TOP3B
Interaction	GPR55 interactions	GBF1 PIEZO1 TARS2 STK11IP FANCA MISP TTI1	2.98e-06	67	188	7	int:GPR55
Cytoband	3p21.3	SEMA3F SACM1L SEMA3B HEMK1	1.10e-04	59	191	4	3p21.3
Cytoband	10p15-p14	AKR1C2 AKR1C3	2.55e-04	6	191	2	10p15-p14
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	SEMA3F TREX1 SACM1L MST1 SEMA3B HEMK1 KLHDC8B	3.83e-04	316	191	7	chr3p21
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	C2CD4B C2CD4A HECW2 C2CD4D CAPN5 SMURF2	1.25e-07	36	120	6	823
GeneFamily	Glycogen phosphorylases	PYGB PYGL PYGM	2.85e-07	3	120	3	437
GeneFamily	PDZ domain containing	SIPA1L3 DVL1 ARHGEF12 PDZD7 ARHGEF11 FRMPD2B RIMS1 SIPA1L2	7.87e-06	152	120	8	1220
GeneFamily	TTT complex	TTI2 TTI1	1.30e-04	3	120	2	1320
GeneFamily	Methyltransferase like	METTL24 CSKMT METTL17	1.35e-03	33	120	3	963
GeneFamily	Ring finger proteins	RNF223 RNF113A PHRF1 RNF43 RNF113B RNF5 RNF111	2.41e-03	275	120	7	58
GeneFamily	Fibronectin type III domain containing	MPL DSCAM NCAM2 VWA1 PTPRU	4.29e-03	160	120	5	555
GeneFamily	Aldo-keto reductases	AKR1C2 AKR1C3	4.34e-03	15	120	2	399
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	DSCAM NCAM2 IGSF10 LRIG3 SIGLEC11	4.41e-03	161	120	5	593
Coexpression	MIKKELSEN_MCV6_LCP_WITH_H3K4ME3	PRRG2 TREX1 AOC1 SIPA1L3 PLEKHA6 ARHGEF11 AKR1C2 AKR1C3 ARAP1	5.12e-06	174	189	9	MM836
Coexpression	ERBB2_UP.V1_UP	GBF1 ACHE VWA1 PTPRU AKR1C2 FER1L4 ASPH CAPN5 MVD	1.04e-05	190	189	9	M2636
Coexpression	GSE37532_TREG_VS_TCONV_CD4_TCELL_FROM_LN_DN	HLA-DRB1 ETV6 NSUN2 FANCA MST1 GSTT2 CLPTM1L SLC2A6 ARAP1	1.57e-05	200	189	9	M8958
Coexpression	GSE5589_LPS_AND_IL10_VS_LPS_AND_IL6_STIM_IL10_KO_MACROPHAGE_45MIN_DN	SLC2A9 CAMKK1 MAGEE1 ASIC3 KANSL1 SLC2A6 RETREG1 PYGB CDK6	1.57e-05	200	189	9	M6636
Drug	heptenitol	MGAM PYGB PYGL PYGM	1.48e-07	7	186	4	CID000188267
Drug	Fluoxetine hydrochloride [59333-67-4]; Up 200; 11.6uM; MCF7; HT_HG-U133A	DSCAM KDM5A ARHGEF12 PLEKHA6 RNF43 SIRT3 EXD3 SLC2A6 MTM1 AKR1C3 MVD	3.57e-07	184	186	11	5356_UP
Drug	3,5-dimethylphenyl isocyanate	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000521488
Drug	5'-deoxy-5'-fluoro-5'-(methylthio)adenosine	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000147839
Drug	NSC758405	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000003201
Drug	3,5-dinitrophenyl phosphate	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000151920
Drug	pyridoxal phosphoglucose	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000196007
Drug	5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000093111
Drug	adenosine-5'-chloromethylphosphonate	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000191554
Drug	hydan	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000008360
Drug	EHMF	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000033931
Drug	pyridoxal 5'-methylenephosphonate	PYGB PYGL PYGM	5.37e-07	3	186	3	CID003082249
Drug	Plp 5'-mpa	PYGB PYGL PYGM	5.37e-07	3	186	3	CID003082151
Drug	glucose-1,2-cyclic phosphate	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000191723
Drug	3'-FFdUrd	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000072260
Drug	2',3',4',5,5'-pentachloro-2-biphenylol	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000119518
Drug	AC1L8XK3	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000409735
Drug	N-acetyl-N'-beta-D-glucopyranosyl urea	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000446801
Drug	riboflavin tetraacetate	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000094186
Drug	2,5-dimethyl-3-furanone	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000085730
Drug	3,5-dinitrophenol	PYGB PYGL PYGM	5.37e-07	3	186	3	CID000011459
Drug	Clorgyline hydrochloride [17780-75-5]; Down 200; 13uM; MCF7; HT_HG-U133A	PRRG2 HDAC6 DYNC2H1 AMBRA1 EML2 WDR59 TRMU RGS20 SEMA3B HEMK1 CAPN5	7.41e-07	198	186	11	3219_DN
Drug	glucosyl fluoride	MGAM PYGB PYGL PYGM	1.36e-06	11	186	4	CID000150967
Drug	9 Da	MGAM PYGB PYGL PYGM	1.36e-06	11	186	4	CID005287565
Drug	1,2-dideoxy-d-arabino-hex-1-enopyranose	MGAM GNE PYGB PYGL PYGM	1.60e-06	25	186	5	CID000089465
Drug	galocitabine	PYGB PYGL PYGM	2.13e-06	4	186	3	CID000065950
Drug	5-deoxyribose-1-phosphate	PYGB PYGL PYGM	2.13e-06	4	186	3	CID000135786
Drug	ingliforib	PYGB PYGL PYGM	2.13e-06	4	186	3	CID006451325
Drug	uric acid riboside	PYGB PYGL PYGM	2.13e-06	4	186	3	CID000164933
Drug	pseudo-dl-glucose	PYGB PYGL PYGM	2.13e-06	4	186	3	CID000125259
Drug	pyridoxal diphosphate	PYGB PYGL PYGM	2.13e-06	4	186	3	CID000125696
Drug	2,5-anhydro-D-mannitol 1-phosphate	PYGB PYGL PYGM	2.13e-06	4	186	3	CID000189134
Drug	AC1LAMW2	PYGB PYGL PYGM	2.13e-06	4	186	3	CID000491364
Drug	FdUrd-C8	PYGB PYGL PYGM	2.13e-06	4	186	3	CID000094262
Drug	Mem-CC	PYGB PYGL PYGM	2.13e-06	4	186	3	CID003081269
Drug	BCIp4A	PYGB PYGL PYGM	2.13e-06	4	186	3	CID000192417
Drug	3'-chloromethotrexate	PYGB PYGL PYGM	2.13e-06	4	186	3	CID000097703
Drug	5-ethyluracil	AKR1C2 PYGB PYGL PYGM	2.91e-06	13	186	4	CID000073267
Drug	Serotonin hydrochloride [153-98-0]; Up 200; 18.8uM; PC3; HT_HG-U133A	SEMA3F FKRP MYO9B POLD2 PTCH1 TRMU RETREG1 HEMK1 NOTCH2 MVD	5.11e-06	196	186	10	4673_UP
Drug	Carisoprodol [78-44-4]; Down 200; 15.4uM; MCF7; HT_HG-U133A	CCDC22 GBF1 PLEKHA6 PTPRU INTS5 SEMA3B LSS CAPN5 MVD ARAP1	5.11e-06	196	186	10	3251_DN
Drug	heptulose-2-P	PYGB PYGL PYGM	5.30e-06	5	186	3	CID000124823
Drug	6-FPLP	PYGB PYGL PYGM	5.30e-06	5	186	3	CID000146246
Drug	gluconohydroximo-1,5-lactone	PYGB PYGL PYGM	5.30e-06	5	186	3	CID009576855
Drug	DHPBU	PYGB PYGL PYGM	5.30e-06	5	186	3	CID000125914
Drug	5'-isobutylthioinosine	PYGB PYGL PYGM	5.30e-06	5	186	3	CID003080910
Drug	indirubin-5-sulphonate	PYGB PYGL PYGM	5.30e-06	5	186	3	CID005288641
Drug	AC1LCUXJ	PYGB PYGL PYGM	5.30e-06	5	186	3	CID000656425
Drug	6-amino-5-bromouracil	PYGB PYGL PYGM	5.30e-06	5	186	3	CID000080578
Drug	etafenone	PYGB PYGL PYGM	5.30e-06	5	186	3	CID000003275
Drug	ddEtUrd	PYGB PYGL PYGM	5.30e-06	5	186	3	CID000451452
Drug	5-trifluoromethyl-2'-deoxycytidine	PYGB PYGL PYGM	5.30e-06	5	186	3	CID000125618
Drug	m-anisidine	PYGB PYGL PYGM	5.30e-06	5	186	3	CID000010824
Drug	2-hydroxypropylphosphonate	PYGB PYGL PYGM	5.30e-06	5	186	3	CID000441028
Drug	6-FDPL	PYGB PYGL PYGM	5.30e-06	5	186	3	CID000129578
Drug	3'-O-methylpyridoxal 5'-phosphate	PYGB PYGL PYGM	5.30e-06	5	186	3	CID003082179
Drug	GlcMan	PYGB PYGL PYGM	5.30e-06	5	186	3	CID000152120
Drug	U66985	PYGB PYGL PYGM	5.30e-06	5	186	3	CID000127224
Drug	AC1O3M08	PYGB PYGL PYGM	5.30e-06	5	186	3	CID006331955
Drug	Bretylium tosylate [61-75-6]; Up 200; 9.6uM; PC3; HT_HG-U133A	SEMA3F IRS4 MYO9B ACHE ARHGEF12 NCAM2 PTPRU NF1 CNTNAP2 TIMELESS	5.35e-06	197	186	10	6674_UP
Drug	4-nitrophenylmaltoheptaoside	MGAM PYGB PYGL PYGM	5.49e-06	15	186	4	CID000173254
Drug	Thioproperazine dimesylate [2347-80-0]; Down 200; 6.2uM; MCF7; HT_HG-U133A	PRRG2 AMBRA1 NCAM2 ARHGEF11 SIRT3 FANCA TRMU INTS5 NF1 G6PC3	5.85e-06	199	186	10	6265_DN
Drug	butylethanolamine	MGAM PYGB PYGL PYGM	7.27e-06	16	186	4	CID000249006
Drug	homonojirimycin	MGAM PYGB PYGL PYGM	9.44e-06	17	186	4	CID000159496
Drug	fagomine	MGAM PYGB PYGL PYGM	9.44e-06	17	186	4	CID000072259
Drug	CV-araU	PYGB PYGL PYGM	1.05e-05	6	186	3	CID006441877
Drug	2-thiothymidine	PYGB PYGL PYGM	1.05e-05	6	186	3	CID003005944
Drug	Carbocyclic Bvdc	PYGB PYGL PYGM	1.05e-05	6	186	3	CID006438602
Drug	2,2-dimethyl-3-hydroxybutyric acid	PYGB PYGL PYGM	1.05e-05	6	186	3	CID000152984
Drug	EdUMP	PYGB PYGL PYGM	1.05e-05	6	186	3	CID003085112
Drug	5'-deoxy-5'-chloroformycin	PYGB PYGL PYGM	1.05e-05	6	186	3	CID000126430
Drug	5-n-propylthioadenosine	PYGB PYGL PYGM	1.05e-05	6	186	3	CID000656428
Drug	AzddCyd	PYGB PYGL PYGM	1.05e-05	6	186	3	CID000451374
Drug	5-Ffdru	PYGB PYGL PYGM	1.05e-05	6	186	3	CID000065561
Drug	Carbocyclic Ivdu	PYGB PYGL PYGM	1.05e-05	6	186	3	CID006439191
Drug	DNPP	PYGB PYGL PYGM	1.05e-05	6	186	3	CID000067056
Drug	5-chloro-indole-2-carboxylic acid	PYGB PYGL PYGM	1.05e-05	6	186	3	CID000082693
Drug	NSC-97433	PYGB PYGL PYGM	1.05e-05	6	186	3	CID000001803
Drug	AR-L57	PYGB PYGL PYGM	1.05e-05	6	186	3	CID000156890
Drug	alpha-(fluoromethyl)dehydroornithine	PYGB PYGL PYGM	1.83e-05	7	186	3	CID006439607
Drug	6-fluoropyridoxal	PYGB PYGL PYGM	1.83e-05	7	186	3	CID003080803
Drug	AC1L3372	PYGB PYGL PYGM	1.83e-05	7	186	3	CID000108025
Drug	1 Gpt	PYGB PYGL PYGM	1.83e-05	7	186	3	CID000101247
Drug	formycins	PYGB PYGL PYGM	1.83e-05	7	186	3	CID000512867
Drug	5'-methylthioinosine	PYGB PYGL PYGM	1.83e-05	7	186	3	CID000161214
Drug	hydantocidin	PYGB PYGL PYGM	1.83e-05	7	186	3	CID000125429
Drug	2',3'-dideoxy-3'-fluorocytidine	PYGB PYGL PYGM	1.83e-05	7	186	3	CID000356019
Drug	Promonta	PYGB PYGL PYGM	1.83e-05	7	186	3	CID000108494
Drug	Withaferin A [5119-48-2]; Down 200; 1uM; MCF7; HT_HG-U133A	SEMA3F DSCAM PGGHG SIPA1L3 ETV6 PLEKHA6 TARS2 RNF43 TIMELESS	1.96e-05	182	186	9	4376_DN
Drug	AC1L3XPY	MGAM PYGB PYGL PYGM	2.31e-05	21	186	4	CID000124005
Drug	I0329	MGAM PYGB PYGL PYGM	2.31e-05	21	186	4	CID000439668
Drug	maltosaccharide	MGAM PYGB PYGL PYGM	2.81e-05	22	186	4	CID005461034
Drug	6-methylpurine	PYGB PYGL PYGM	2.92e-05	8	186	3	CID005287547
Drug	Etafenone [inn]	PYGB PYGL PYGM	2.92e-05	8	186	3	CID000066659
Drug	AC1NUVX5	PYGB PYGL PYGM	2.92e-05	8	186	3	CID005461894
Drug	amorphin	PYGB PYGL PYGM	2.92e-05	8	186	3	CID000122792
Drug	Cimetidine [51481-61-9]; Down 200; 15.8uM; MCF7; HT_HG-U133A	SEMA3F MYO9B ASIC3 ARHGEF11 EXD3 NF1 MTM1 ASPH HEMK1	2.99e-05	192	186	9	4144_DN
Drug	AC1L6KTW	EBP PYGB PYGL PYGM LSS MVD	3.20e-05	74	186	6	CID000247705
Drug	Isoetharine mesylate salt [7279-75-6]; Down 200; 12uM; MCF7; HT_HG-U133A	DYNC2H1 MYO9B SIPA1L3 AMBRA1 SIRT3 NF1 MTM1 LSS HEMK1	3.38e-05	195	186	9	3451_DN
Drug	ginsenoside	MGAM PYGB PYGL PYGM	3.38e-05	23	186	4	CID000092797
Drug	CP-944629 [668990-94-1]; Up 200; 10uM; PC3; HT_HG-U133A	SEMA3F SIPA1L3 SIRT3 FANCA NF1 NALF1 SLC2A6 CNTNAP2 SMPD1	3.52e-05	196	186	9	7502_UP
Disease	Charcot-Marie-Tooth disease (biomarker_via_orthology)	GSTT2B GSTT2	3.87e-05	2	184	2	DOID:10595 (biomarker_via_orthology)
Disease	Neoplasms, Hormone-Dependent	AKR1C2 AKR1C3	1.16e-04	3	184	2	C0027661
Disease	Fibrosarcoma	ETV6 NF1	1.16e-04	3	184	2	C0016057
Disease	lymphocyte count	FNIP2 GLT6D1 NWD1 GBF1 AOC1 DNAH10 HLA-DRB1 PIEZO1 PLEKHA6 ARHGEF11 SIRT3 DIP2A NUDT3 RASAL3 CHEK2 TMEM38A PAPPA CORO7 VWA2 NOTCH2 CDK6	3.36e-04	1464	184	21	EFO_0004587
Disease	Hermaphroditism	AKR1C2 AKR1C3	3.82e-04	5	184	2	C0019269
Disease	Ambiguous Genitalia	AKR1C2 AKR1C3	3.82e-04	5	184	2	C0266362
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	3.82e-04	5	184	2	DOID:11198 (is_implicated_in)
Disease	Pseudohermaphroditism	AKR1C2 AKR1C3	3.82e-04	5	184	2	C0033804
Disease	Short rib-polydactyly syndrome, Verma-Naumoff type	DYNC2H1 WDR35	3.82e-04	5	184	2	C0432197
Disease	Intersex Conditions	AKR1C2 AKR1C3	3.82e-04	5	184	2	C2930618
Disease	Sex Differentiation Disorders	AKR1C2 AKR1C3	3.82e-04	5	184	2	C2930619
Disease	Endometrial Neoplasms	SEMA3F RNF43 SEMA3B AKR1C3	4.77e-04	58	184	4	C0014170
Disease	PROSTATE CANCER, HEREDITARY, 1	MYO9B RNF43 CHEK2 B3GAT1	5.43e-04	60	184	4	C4722327
Disease	liposarcoma	NF1 CDK6	5.71e-04	6	184	2	C0023827
Disease	cortolone glucuronide (1) measurement	AKR1C2 AKR1C3	5.71e-04	6	184	2	EFO_0800552
Disease	foot muscle strength measurement	DSCAM SIPA1L2	5.71e-04	6	184	2	EFO_0009699
Disease	1,5 anhydroglucitol measurement	MGAM NCAM2 RAB3GAP1	7.74e-04	29	184	3	EFO_0008009
Disease	Disorders of Sex Development	AKR1C2 AKR1C3	7.96e-04	7	184	2	C0036875
Disease	Prostate cancer, familial	MYO9B RNF43 CHEK2 B3GAT1	9.22e-04	69	184	4	C2931456
Disease	Ependymoblastoma	PTCH1 NOTCH2	1.06e-03	8	184	2	C0700367
Disease	myasthenia gravis (is_implicated_in)	ACHE HLA-DRB1	1.06e-03	8	184	2	DOID:437 (is_implicated_in)
Disease	Neuroectodermal Tumor, Primitive	PTCH1 NOTCH2	1.06e-03	8	184	2	C0206663
Disease	Cerebral Primitive Neuroectodermal Tumor	PTCH1 NOTCH2	1.06e-03	8	184	2	C0751675
Disease	Spongioblastoma	PTCH1 NOTCH2	1.06e-03	8	184	2	C0334584
Disease	Medulloepithelioma	PTCH1 NOTCH2	1.06e-03	8	184	2	C0334596
Disease	hemoglobin measurement, mean corpuscular hemoglobin concentration	PIEZO1 TMEM79	1.06e-03	8	184	2	EFO_0004509, EFO_0004528
Disease	Endometrial Carcinoma	SEMA3F RNF43 SEMA3B AKR1C3	1.08e-03	72	184	4	C0476089
Disease	joint hypermobility measurement	PIEZO1 NEDD4 SMURF2	1.13e-03	33	184	3	EFO_0007905
Disease	intellectual disability (implicated_via_orthology)	IRS4 KDM5A NSUN2 KANSL1	1.26e-03	75	184	4	DOID:1059 (implicated_via_orthology)
Disease	non-melanoma skin carcinoma	GABRG3 HLA-DRB1 DCLRE1B FANCA CLPTM1L C2CD4D MYO15A	1.43e-03	265	184	7	EFO_0009260
Disease	uric acid measurement	SLC2A9 DSCAM DYNC2H1 SIPA1L3 LMTK2 PLEKHA6 HSF5 FANCA RGS20 PYGB PYGM	1.64e-03	610	184	11	EFO_0004761
Disease	celiac disease (is_implicated_in)	MYO9B HLA-DRB1	1.68e-03	10	184	2	DOID:10608 (is_implicated_in)
Disease	abdominal obesity-metabolic syndrome (implicated_via_orthology)	SLC2A9 SIRT3	1.68e-03	10	184	2	DOID:0060611 (implicated_via_orthology)
Disease	hepatocyte growth factor-like protein measurement	SEMA3F MST1 KLHDC8B	1.71e-03	38	184	3	EFO_0008154
Disease	cryptorchidism (biomarker_via_orthology)	KDM5A GFER	2.05e-03	11	184	2	DOID:11383 (biomarker_via_orthology)
Disease	Intellectual Disability	TREX1 KDM5A TTI2 RNF113A NSUN2 GFER NF1 KANSL1 LSS	2.06e-03	447	184	9	C3714756
Disease	neuroimaging measurement, brain volume measurement	PTCH1 ARHGEF11 NF1 KANSL1 PYGB PAPPA CDK6	2.20e-03	286	184	7	EFO_0004346, EFO_0006930
Disease	autistic disorder (is_implicated_in)	HLA-DRB1 NF1 CNTNAP2	2.29e-03	42	184	3	DOID:12849 (is_implicated_in)
Disease	Hematologic Neoplasms	MPL ETV6	2.45e-03	12	184	2	C0376545
Disease	Childhood Medulloblastoma	MPL PTCH1 CDK6	2.45e-03	43	184	3	C0278510
Disease	Melanotic medulloblastoma	MPL PTCH1 CDK6	2.45e-03	43	184	3	C1275668
Disease	Medullomyoblastoma	MPL PTCH1 CDK6	2.45e-03	43	184	3	C0205833
Disease	Desmoplastic Medulloblastoma	MPL PTCH1 CDK6	2.45e-03	43	184	3	C0751291
Disease	Adult Medulloblastoma	MPL PTCH1 CDK6	2.45e-03	43	184	3	C0278876
Disease	Crohn's disease of large bowel	TAGAP HLA-DRB1 MST1	2.62e-03	44	184	3	C0156147
Disease	IIeocolitis	TAGAP HLA-DRB1 MST1	2.62e-03	44	184	3	C0949272
Disease	Crohn's disease of the ileum	TAGAP HLA-DRB1 MST1	2.62e-03	44	184	3	C0267380
Disease	Regional enteritis	TAGAP HLA-DRB1 MST1	2.62e-03	44	184	3	C0678202
Disease	nasopharyngeal neoplasm	HLA-DRB1 CLPTM1L NALF1 EPC1 CNTNAP2	2.62e-03	151	184	5	EFO_0004252
Disease	testosterone measurement	AOC1 DSCAM MYO9B ACHE HLA-DRB1 AKR1C2 GSTT2B LIPE NF1 NALF1 CNTNAP2 CHEK2 AKR1C3 MYO15A ARAP1 FAM110B CDK6	2.70e-03	1275	184	17	EFO_0004908
Disease	interleukin 17 measurement	AMBRA1 FANCA TRIB3	2.79e-03	45	184	3	EFO_0008174
Disease	3-formylindole measurement	GSTT2B GSTT2	2.88e-03	13	184	2	EFO_0801025
Disease	intercellular adhesion molecule 5 measurement	MRPL4 RAVER1	2.88e-03	13	184	2	EFO_0008164
Disease	Short Rib-Polydactyly Syndrome	DYNC2H1 WDR35	2.88e-03	13	184	2	C0036996
Disease	leukemia (is_implicated_in)	ETV6 AKR1C3	2.88e-03	13	184	2	DOID:1240 (is_implicated_in)
Disease	autism spectrum disorder	NWD1 MYO9B SSUH2 KANSL1 TMEM38A	3.02e-03	156	184	5	EFO_0003756
Disease	level of Phosphatidylethanolamine (18:1_18:1) in blood serum	CNTNAP2 RNF111	3.35e-03	14	184	2	OBA_2045142
Disease	Saldino-Noonan Syndrome	DYNC2H1 WDR35	3.35e-03	14	184	2	C0036069
Disease	Majewski Syndrome	DYNC2H1 WDR35	3.35e-03	14	184	2	C0024507
Disease	lung adenocarcinoma (is_implicated_in)	PTCH1 RNF43 CLPTM1L	3.56e-03	49	184	3	DOID:3910 (is_implicated_in)
Disease	Medulloblastoma	MPL PTCH1 CDK6	3.77e-03	50	184	3	C0025149
Disease	Crohn Disease	TAGAP HLA-DRB1 MST1	3.77e-03	50	184	3	C0010346
Disease	TPE interval measurement	AOC1 LRIG3 PYGB	4.21e-03	52	184	3	EFO_0004644
Disease	lung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma	DVL1P1 DYNC2H1 DVL1	4.21e-03	52	184	3	EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575
Disease	Congenital total cataract	SIPA1L3 LSS	4.38e-03	16	184	2	C0266539
Disease	coronary thrombosis, GM11992	DSCAM METTL24	4.38e-03	16	184	2	EFO_0001124, EFO_1000883
Disease	idiopathic scoliosis (implicated_via_orthology)	DNAH10 SSPOP	4.38e-03	16	184	2	DOID:0060250 (implicated_via_orthology)
Disease	myopia (is_implicated_in)	CPSF1 PRIMPOL	4.38e-03	16	184	2	DOID:11830 (is_implicated_in)
Disease	Leukemia, Myelocytic, Acute	ETV6 FANCA NF1 NOTCH2 CDK6	4.68e-03	173	184	5	C0023467
Disease	alkaline phosphatase measurement	AOC1 PGGHG HLA-DRB1 PTCH1 GSTT2B MRPL4 EDEM3 NF1 KANSL1 SLC2A6 CHEK2 PYGB PYGL B3GAT1	4.73e-03	1015	184	14	EFO_0004533
Disease	Muscle hypotonia	KANSL1 LSS	4.95e-03	17	184	2	C0026827
Disease	Moyamoya Disease	HLA-DRB1 NF1	4.95e-03	17	184	2	C0026654
Disease	Glioblastoma Multiforme	NF1 TRIB3 NOTCH2 CDK6	5.22e-03	111	184	4	C1621958
Disease	urinary albumin to creatinine ratio	GABRG3 MGAM HLA-DRB1 EDEM3 RGS20	5.40e-03	179	184	5	EFO_0007778
Disease	Drugs used in diabetes use measurement	C2CD4B PTCH1 NF1 NUDT3 NOTCH2 ARAP1	5.44e-03	255	184	6	EFO_0009924
Disease	Libman-Sacks Disease	TREX1 HLA-DRB1 PHRF1	5.72e-03	58	184	3	C0242380
Disease	ankylosing spondylitis (is_implicated_in)	KDM5A HLA-DRB1	6.17e-03	19	184	2	DOID:7147 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WLHPEDPARLREALS	ACHE	416	P22303
HWLVVEDAPRRTPLT	B3GAT1	116	Q9P2W7
WRHFRPRTPSLHDSD	EPC1	526	Q9H2F5
VSRPIDHDLANWTPA	BCAR1	711	P56945
WSTFHRPELVRPALE	AKR1C3	86	P42330
DSRVLWAPAEAHPLS	SMPD1	51	P17405
DTWRLVNPPARPHLE	FBXO10	901	Q9UK96
RGIPHRSPVSVDDLW	ARHGEF4	56	Q9NR80
LVLAEPRRKPSTFWH	ARHGEF4	666	Q9NR80
EHLPPRTRNSGIWES	ARHGEF11	1286	O15085
DVWSRLEEAGHRPPN	ACSM5	61	Q6NUN0
PRASAWHPRIVAALV	ARMC5	381	Q96C12
EDWPRDVALPRQAFH	CDK6	241	Q00534
DVWHPELTPQQRRSL	ASPH	741	Q12797
RELRLDEPPHTCWSS	CAPN5	496	O15484
LENITNPWSPRHRVV	AOC1	536	P19801
RRHVSINSARWLPEP	AMBRA1	1006	Q9C0C7
EDWVHRTSRLPPQED	CCDC22	226	O60826
PKARFTTEEALRHPW	CHEK2	471	O96017
IPHTPIAVDFWSLRR	DCLRE1B	6	Q9H816
QPDLPDVWLRRPSTH	DISP2	1381	A7MBM2
IPDSHLPVSEERWAL	ARHGEF12	1236	Q9NZN5
RQNRSSWIDPPEEEH	ANO8	711	Q9HCE9
DLDSVRHARRVPWLP	NWD1	441	Q149M9
VWDLSDAHRSRVPAP	NWD1	1196	Q149M9
WRDTERHLAPHENPI	RASSF8	46	Q8NHQ8
GAERDVRIWPLHPSL	RASAL3	241	Q86YV0
PSVSRPHWAARNAAL	RAVER1	561	Q8IY67
DLDPIQAPHWSVRVR	RAB3GAP1	301	Q15042
DWDAVPHSRHTQIRP	NSUN2	376	Q08J23
DEALPPNWEARIDSH	HECW2	806	Q9P2P5
PAHLRLQPIYWSRDD	ETV6	51	P41212
DAHQGRPTWALRPED	MISP	101	Q8IVT2
DDPIDRRPWTQQHLE	NOTCH2	1781	Q04721
APHSWPESRLESKAR	MAGEE1	736	Q9HCI5
TTWEDPRLKIPAHLR	NEDD4	866	P46934
RTSRVHWIAEEPPAA	TRMU	306	O75648
PLPSWVARLDLSHNR	LRIG3	71	Q6UXM1
RAGAWRAPLEHRESP	MYO15A	896	Q9UKN7
QDELSHLLAWTEPRP	ERVFC1-1	391	P60608
LIWSREINGPPRDHL	GAB3	256	Q8WWW8
RLRSATWKPVPDSHQ	GLB1L3	556	Q8NCI6
DPRHPELVSSWLQSR	HEMK1	296	Q9Y5R4
ASHISPRAWRRPTIE	CAMKK1	96	Q8N5S9
SARVARLNPTWNHPD	MYG1	196	Q9HB07
ILPWQEPALNTHLSR	MGAM	1716	O43451
TDFRVHWAQHPLRPE	EDEM3	391	Q9BZQ6
QRWVPLHDPRDTRAG	FER1L4	126	A9Z1Z3
ERPEWIHVDSRPFAS	G6PC3	236	Q9BUM1
IRDWHLKQSPASPER	KRT13	136	P13646
TDWDPRSQAALSLPH	C2CD4B	76	A6NLJ0
APLSQRWTVPELLTH	C9orf131	761	Q5VYM1
PFRAEPTHWCLLVRE	CPSF1	776	Q10570
HTEARPPRRESWISD	CORO7	11	P57737
EWTLRVRHISPTAPD	POLD2	366	P49005
LVSSSRHPDRWIVPG	NUDT3	36	O95989
LRPNWLLTEPLSREH	PDZD7	746	Q9H5P4
WDRLHAQPRLGTVPT	CSKMT	36	A8MUP2
APDELYTPHSWLLRV	LSS	281	P48449
RSHERPDRKESVAWP	PHRF1	1141	Q9P1Y6
SVQPWERRTFPLAHS	KANSL1	1031	Q7Z3B3
SIARQVAPESHWPEL	MVD	181	P53602
WLSPEKRPAAEDVHR	LMTK2	391	Q8IWU2
PLRRSRLTPNDLHWA	ASIC3	96	Q9UHC3
ARPRTVWLGHPEKRD	ATP9A	36	O75110
PHLEAELWPSQSRLS	PGGHG	656	Q32M88
TVRDIPHWLNPTRVE	PAPPA	1521	Q13219
LLWFPLDSHARARPD	CHRDL2	16	Q6WN34
PEHLRATVRWDYQPD	RNF113A	186	O15541
PDHWYPSDLQARARV	GSTT2B	81	P0CG30
RVSWAEARAPHVCRP	SLC2A6	261	Q9UGQ3
RWHKPRPAAANAATV	INSM2	311	Q96T92
WRILQATHPPSEDRF	KDM5A	1466	P29375
LHPLQSTTPDFWRLV	PTPRU	1251	Q92729
REPLEHGAWRLPVSI	PRR7	251	Q8TB68
LHSPERERGRWSPSL	RIMS1	1126	Q86UR5
GTELSRRHNWTKPEP	C6orf132	926	Q5T0Z8
RLWLTAEVHPNFTPI	DYNC2H1	3806	Q8NCM8
PHSSRPRAWKQDLEQ	GUCA1ANB	41	X6R8D5
SVCAEPWRHQRARDP	FAM157B	316	P0CG42
VDPERVLWSLRDHPL	FBH1	306	Q8NFZ0
PSARRIDPQHWAALL	IGSF10	746	Q6WRI0
DHSGWVRPALRARAP	KLF1	131	Q13351
RTPLSDTLHLPVWVD	GNE	501	Q9Y223
HRQVRPEAWLSSRPS	CD1C	201	P29017
LHPDSSRWIPERISL	GABRG3	356	Q99928
LRLSDWFHPRKRPDV	GLT6D1	31	Q7Z4J2
QHLRETAWHDPIVPA	C19orf71	111	A6NCJ1
NRERPWASSLTHSPE	FRMPD2B	251	Q6IN97
DRSVAWPCPDRHLRE	FNIP2	696	Q9P278
EDVASLSWRPLHLPS	FANCA	886	O15360
PDHWYPSDLQARARV	GSTT2	81	P0CG29
WAFLPESPHTRRRES	C2CD4D	91	B7Z1M9
NLHQEPREPLYVSWR	DENND4C	1776	Q5VZ89
HPSVTSPLTVEWRAR	HLA-DRB1	206	P01911
AEPPDHLTITRRRTW	CEP170P1	101	Q96L14
SRNWPPHRSEATDLH	FAM110B	141	Q8TC76
WSTHTPLDEERDPLL	GBF1	26	Q92538
RHGRPIDPDTLTLLW	SLC2A9	96	Q9NRM0
HLHVFNPRENTWRPL	KLHDC7B	321	Q96G42
DLEARTWTRHPSLPS	KLHDC8B	196	Q8IXV7
VENRLPQWLPAHDSR	KRCC1	81	Q9NPI7
PQWLPAHDSRLRLDS	KRCC1	86	Q9NPI7
QPIDIFLSHDWPRSI	DBR1	166	Q9UK59
VRSPTPLNDDQWHRV	CNTNAP2	871	Q9UHC6
WSARLLTRAHVECPP	CRIPAK	51	Q8N1N5
RPIDPAAWLSHTAAL	DVL1	356	O14640
SDSHQPLWSRIIEDP	EML2	406	O95834
PLQSHSSVEPWLDRV	DIP2A	156	Q14689
WDSHHPEVPQRILRI	HDAC6	496	Q9UBN7
AAARQPPLATAHARW	FKRP	241	Q9H9S5
PPLATAHARWKAERE	FKRP	246	Q9H9S5
RWDAQIPHQHRFTPE	MST1	306	P26927
QEWLSRDLLHRPSDA	C1orf127	246	Q8N9H9
RPIDPAAWLSHTAAL	DVL1P1	356	P54792
LRLDNFVPNDRPTWH	EBP	16	Q15125
SLERITKPHPDFRLW	DNAH10	3951	Q8IVF4
ELESHSPLSVPRDWK	SACM1L	506	Q9NTJ5
RGSPEEAHRWPRITQ	METTL17	376	Q9H7H0
TDWDPRSQAALSLPH	C2CD4A	81	Q8NCU7
PPAARDDRAAHRLWE	DHRS13	291	Q6UX07
EEPPSIWRLFHRQAQ	PRIMPOL	36	Q96LW4
KSVSRSDWQPEPHQR	LIPE	6	Q05469
PESHPIIWQSEERRR	LRCH2	541	Q5VUJ6
RELHSWEPEPDVRTA	HGH1	316	Q9BTY7
AIPRANPLSLDSARW	IRS4	981	O14654
VEPCRSDHWPLSDVR	FIBP	311	O43427
HRLSIDWRDPHPAVA	METTL24	226	Q5JXM2
AHTLTTDWRLPTPRA	DSCAM	1761	O60469
RRPIAQWHSLKPEEE	SYT2	396	Q8N9I0
HTAVVSTPPRWLAER	TARS2	21	Q9BW92
LDRTPVPHRIWQNSL	HSF5	221	Q4G112
ATEEEVTPQHRLWPL	STK11IP	921	Q8N1F8
SQSWAALVVLPHIRP	UTP20	516	O75691
TDSWAPPLEIVNHRS	DROSHA	341	Q9NRR4
PTHRRPVQAWVESLR	MRPL4	56	Q9BYD3
NREPLIIHWAASPQR	SEMA3F	86	Q13275
RWLNDPSFIHAELIP	SEMA3F	251	Q13275
EPTAELAAHSWRLSP	SSPOP	1166	A2VEC9
LHQWLETRPERQECP	RNF5	51	Q99942
SPLPERWKQSRTVHA	TAGAP	661	Q8N103
PIRAPGHLRATVRWD	RNF113B	176	Q8IZP6
PDERPRLSHCIAESW	RETREG1	161	Q9H6L5
PTIASHELRADLPTW	RGS20	231	O76081
HELRADLPTWEESPA	RGS20	236	O76081
PLEPHLWQRERASEV	SAMD9L	511	Q8IVG5
ASQANIRPHRPEWVH	PTCH1	936	Q13635
HSRPDPLQQRTAWAI	RNF43	226	Q68DV7
PHDRSLRDARAPWKT	SMIM32	86	A0A1B0GUA5
RRNTTWHRVPTPALQ	SIPA1L2	1061	Q9P2F8
EPLWHVPAQARLSAI	SIPA1L3	1221	O60292
DLVGPLAWHPRSRDV	SIRT3	346	Q9NTG7
EEPPAVSLLQDWSRH	SPINDOC	331	Q9BUA3
AHQSRLPSPWVLRSE	PPP1R26	1031	Q5T8A7
WPPEEHARATVERDL	INTS5	831	Q6P9B9
TREWVARHPQVPEAR	SOWAHB	306	A6NEL2
LEDLPPEQWSHTTVR	SATB1	176	Q01826
RPQEQRSWPSFLEHR	SSUH2	56	Q9Y2M2
PPDREELGRHSWAVL	GFER	96	P55789
WSNSHRPELVRPALE	AKR1C2	86	P52895
HDGLVWPSEPSRVSR	ARAP1	1396	Q96P48
SALDEPVSHWRPRLA	CLPTM1L	161	Q96KA5
PAHLRREEPVWLEGT	RNF223	126	E7ERA6
VSTWHDPRVPRDLSN	SMURF2	276	Q9HAU4
SHARPRSLRVSWAPA	VWA1	341	Q6PCB0
SRRAPTWSPEEEAHL	TIMELESS	816	Q9UNS1
DRISPPWALEDKRHA	PLEKHA6	381	Q9Y2H5
PEELQAWLREHRPEN	ZSCAN30	101	Q86W11
SRNRIPVLSWIHPEN	MTM1	221	Q13496
SNPPASIHWRRDKLV	NCAM2	426	O15394
TNHTVLPEALERWPV	PYGM	376	P11217
SSHPRQAPERSAWEL	RNF111	796	Q6ZNA4
LPLNTSHIWHPRIRE	SLC23A1	141	Q9UHI7
THSLEQPWTTPRSRE	TTI2	156	Q6NXR4
LQLPLHPSWEASRRR	SRFBP1	396	Q8NEF9
QRPSLRTEPHDSRWL	SEMA3B	206	Q13214
LSTPIIWRRGHEPQS	TSPYL1	351	Q9H0U9
PLAPTRSHLWEAAQV	TRIB3	321	Q96RU7
LWPLSIHDPTRRARV	TPRG1L	46	Q5T0D9
RIPRANHWDLELLTP	PRRG2	46	O14669
HPDPTERKWAEAVVR	TMEM79	166	Q9BSE2
TNHTVLPEALERWPV	PYGB	376	P11216
RFPRWEELHALASEP	VWA2	186	Q5GFL6
HIRTRWELSQPDSIP	NF1	1826	P21359
HQAVRLPTPNLHWRE	MPL	386	P40238
PLWSPEAERSHSLSQ	NUP153	206	P49790
DKDHERPLPALSWAR	PITPNM3	951	Q9BZ71
VPTLGHRNPWVARDS	ZNF333	156	Q96JL9
HRNPWVARDSAVPAR	ZNF333	161	Q96JL9
ETPWARHPFGRQLLE	WDR59	716	Q6PJI9
PDLPSRFLHWRQVLS	TRIM16	406	O95361
LPRWAHRQDAVSGTP	PIEZO1	721	Q92508
ASQFIEDNPHPRLWR	WDR35	686	Q9P2L0
EDNPHPRLWRLLAEA	WDR35	691	Q9P2L0
TNHTVLPEALERWPV	PYGL	376	P06737
RPQALLRWVDAHARP	TREX1	211	Q9NSU2
PSPAHLRAWTVERKR	USP40	1016	Q9NVE5
LQDRVLSSSHPWGPR	SIGLEC11	301	Q96RL6
PGAVELSRRHPIASW	TMEM38A	41	Q9H6F2
WPSLVHRLTRDAPLA	TTI1	911	O43156
PEELQAWVRQHRPVS	ZSCAN23	101	Q3MJ62
EVRSKHPTPLWNLSD	NALF1	206	B1AL88
LPIPRENVHLLASWE	EXD3	366	Q8N9H8
NDSPVHRVLLWPRRA	MYO9B	81	Q13459