Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionendoribonuclease activity, cleaving miRNA-paired mRNA

AGO2 AGO3

3.70e-0521222GO:0090624
GeneOntologyMolecularFunctioncarbohydrate binding

ENPP2 LGALS4 CD22 P4HA1 CRYBG1 C4A C4B SIGLEC11 TALDO1

1.23e-043101229GO:0030246
GeneOntologyMolecularFunctionRNA endonuclease activity

AGO2 AGO1 AGO4 AGO3 DROSHA

1.23e-04791225GO:0004521
GeneOntologyMolecularFunctionRNA nuclease activity

AGO2 AGO1 AGO4 AGO3 DROSHA N4BP1

1.89e-041361226GO:0004540
GeneOntologyMolecularFunctionmiRNA binding

AGO2 AGO1 AGO4 AGO3

2.10e-04481224GO:0035198
GeneOntologyMolecularFunctionuridine kinase activity

CMPK1 UCK1

2.20e-0441222GO:0004849
GeneOntologyMolecularFunctionnuclease activity

AGO2 ENPP2 AGO1 AGO4 AGO3 DROSHA N4BP1

5.50e-042311227GO:0004518
GeneOntologyMolecularFunctionregulatory RNA binding

AGO2 AGO1 AGO4 AGO3

5.63e-04621224GO:0061980
GeneOntologyMolecularFunctionsingle-stranded RNA binding

PATL2 AGO2 AGO1 AGO4 AGO3

6.00e-041111225GO:0003727
GeneOntologyBiologicalProcesssiRNA-mediated post-transcriptional gene silencing

AGO2 AGO1 AGO4 AGO3

1.09e-0941204GO:0140766
GeneOntologyBiologicalProcesssiRNA-mediated gene silencing by mRNA destabilization

AGO2 AGO1 AGO4 AGO3

1.09e-0941204GO:0090625
GeneOntologyBiologicalProcesspre-miRNA processing

AGO2 AGO1 AGO4 AGO3 DROSHA

3.59e-08171205GO:0031054
GeneOntologyBiologicalProcessRNA secondary structure unwinding

AGO2 AGO1 AGO4 AGO3

1.34e-0791204GO:0010501
GeneOntologyBiologicalProcessRISC complex assembly

AGO2 AGO1 AGO4 AGO3

2.23e-07101204GO:0070922
GeneOntologyBiologicalProcessmiRNA processing

AGO2 AGO1 AGO4 AGO3 DROSHA

8.59e-06481205GO:0035196
GeneOntologyBiologicalProcessregulatory ncRNA processing

AGO2 AGO1 AGO4 AGO3 DROSHA

7.17e-05741205GO:0070918
GeneOntologyBiologicalProcessmaintenance of postsynaptic specialization structure

SHANK1 ITGB3 DLG2

1.23e-04171203GO:0098880
GeneOntologyCellularComponentRISC-loading complex

AGO2 AGO1 AGO4 AGO3

2.41e-07101244GO:0070578
GeneOntologyCellularComponentendoribonuclease complex

AGO2 AGO1 AGO4 AGO3 DROSHA

2.54e-06371245GO:1902555
GeneOntologyCellularComponentendonuclease complex

AGO2 AGO1 AGO4 AGO3 DROSHA

5.44e-06431245GO:1905348
GeneOntologyCellularComponentP-body

PATL2 AGO2 MEX3A AGO1 AGO4 AGO3

3.26e-051021246GO:0000932
GeneOntologyCellularComponentanchoring collagen complex

COL12A1 COL14A1

1.04e-0431242GO:0030934
GeneOntologyCellularComponentcytoplasmic ribonucleoprotein granule

PATL2 AGO2 TRIM25 CKAP5 MEX3A AGO1 AGO4 AGO3

2.06e-042691248GO:0036464
GeneOntologyCellularComponentribonucleoprotein granule

PATL2 AGO2 TRIM25 CKAP5 MEX3A AGO1 AGO4 AGO3

3.19e-042871248GO:0035770
GeneOntologyCellularComponentFACIT collagen trimer

COL12A1 COL14A1

5.15e-0461242GO:0005593
GeneOntologyCellularComponentsymbiont cell surface

C4A C4B

9.55e-0481242GO:0106139
GeneOntologyCellularComponentother organism part

C4A C4B

1.22e-0391242GO:0044217
MousePhenomidline facial cleft

ZEB1 APAF1 GTF2IRD1 GTF2I

8.12e-0619984MP:0000108
MousePhenodilated allantois

ENPP2 GTF2IRD1 GTF2I

1.82e-058983MP:0004557
DomainArgonaute_N

AGO2 AGO1 AGO4 AGO3

1.57e-0941194IPR032474
DomainArgonaute_Mid_dom

AGO2 AGO1 AGO4 AGO3

1.57e-0941194IPR032473
DomainArgoL2

AGO2 AGO1 AGO4 AGO3

1.57e-0941194IPR032472
DomainArgoN

AGO2 AGO1 AGO4 AGO3

1.57e-0941194PF16486
DomainArgoMid

AGO2 AGO1 AGO4 AGO3

1.57e-0941194PF16487
DomainArgoL2

AGO2 AGO1 AGO4 AGO3

1.57e-0941194PF16488
DomainDUF1785

AGO2 AGO1 AGO4 AGO3

7.79e-0951194SM01163
DomainArgoL1

AGO2 AGO1 AGO4 AGO3

2.33e-0861194PF08699
DomainArgoL1

AGO2 AGO1 AGO4 AGO3

2.33e-0861194IPR014811
DomainPIWI

AGO2 AGO1 AGO4 AGO3

1.08e-0781194PS50822
DomainPiwi

AGO2 AGO1 AGO4 AGO3

1.08e-0781194SM00950
DomainPiwi

AGO2 AGO1 AGO4 AGO3

1.08e-0781194PF02171
DomainPiwi

AGO2 AGO1 AGO4 AGO3

1.08e-0781194IPR003165
DomainPAZ

AGO2 AGO1 AGO4 AGO3

1.93e-0791194PS50821
DomainPAZ

AGO2 AGO1 AGO4 AGO3

1.93e-0791194SM00949
DomainPAZ

AGO2 AGO1 AGO4 AGO3

1.93e-0791194PF02170
DomainPAZ_dom

AGO2 AGO1 AGO4 AGO3

1.93e-0791194IPR003100
DomainVWFA

COL12A1 VWA8 ITGB3 HMCN1 VWA5A COL14A1

1.39e-05821196PS50234
DomainVWA

COL12A1 VWA8 ITGB3 HMCN1 VWA5A COL14A1

1.60e-05841196SM00327
DomainTF_II-I

GTF2IRD1 GTF2I

4.03e-0521192IPR016659
DomainVWF_A

COL12A1 VWA8 ITGB3 HMCN1 VWA5A COL14A1

4.08e-05991196IPR002035
Domain-

COL12A1 ITGB3 HMCN1 VWA5A COL14A1

1.09e-047411953.40.50.410
Domain-

AGO2 AGO1 AGO4 AGO3

2.26e-044711943.30.420.10
Domain-

GTF2IRD1 GTF2I

2.40e-04411923.90.1460.10
DomainGTF2I

GTF2IRD1 GTF2I

2.40e-0441192PS51139
DomainGTF2I

GTF2IRD1 GTF2I

2.40e-0441192PF02946
DomainGTF2I

GTF2IRD1 GTF2I

2.40e-0441192IPR004212
DomainAnaphylatoxin_comp_syst

C4A C4B

3.98e-0451192IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

3.98e-0451192IPR001840
DomainVWA

COL12A1 VWA8 VWA5A COL14A1

4.46e-04561194PF00092
DomainIg-like_fold

SLAMF8 BOC IL12RB1 COL12A1 SGCA ICAM4 REL PKHD1L1 IGSF10 HMCN1 CD22 COL14A1 SIGLEC11

5.66e-0470611913IPR013783
DomainPAK_BD

PAK2 PAK3

5.94e-0461192IPR033923
DomainANATO

C4A C4B

8.28e-0471192SM00104
DomainANAPHYLATOXIN_2

C4A C4B

8.28e-0471192PS01178
DomainANAPHYLATOXIN_1

C4A C4B

8.28e-0471192PS01177
DomainANATO

C4A C4B

8.28e-0471192PF01821
DomainAnaphylatoxin/fibulin

C4A C4B

8.28e-0471192IPR000020
DomainRNaseH-like_dom

AGO2 AGO1 AGO4 AGO3

9.84e-04691194IPR012337
Domain-

BOC IL12RB1 COL12A1 SGCA ICAM4 REL PKHD1L1 IGSF10 HMCN1 CD22 COL14A1 SIGLEC11

1.08e-03663119122.60.40.10
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

1.10e-0381192IPR019565
DomainThiol-ester_cl

C4A C4B

1.10e-0381192PF10569
DomainMacrogloblnA2_CS

C4A C4B

1.10e-0381192IPR019742
DomainA2M

C4A C4B

1.75e-03101192PF00207
DomainA2M_N_2

C4A C4B

1.75e-03101192IPR011625
DomainA2M_comp

C4A C4B

1.75e-03101192IPR011626
DomainA2M_recep

C4A C4B

1.75e-03101192PF07677
DomainA2M_comp

C4A C4B

1.75e-03101192PF07678
DomainA2M_N

C4A C4B

1.75e-03101192PF01835
DomainA2M_N

C4A C4B

1.75e-03101192IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

1.75e-03101192IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

1.75e-03101192PS00477
DomainHydrolase_3

ATP10D ATP2B3

1.75e-03101192PF08282
DomainA2M_N_2

C4A C4B

1.75e-03101192PF07703
DomainMacroglobln_a2

C4A C4B

1.75e-03101192IPR001599
DomainKH_1

MEX3D MEX3C MEX3A

1.81e-03381193PF00013
Domain-

MEX3D MEX3C MEX3A

1.95e-033911933.30.1370.10
DomainPDZ

SHANK1 PREX2 LMO7 DLG2 SNTB1

2.10e-031411195PF00595
DomainKH

MEX3D MEX3C MEX3A

2.10e-03401193SM00322
DomainKH_dom

MEX3D MEX3C MEX3A

2.10e-03401193IPR004087
DomainKH_TYPE_1

MEX3D MEX3C MEX3A

2.42e-03421193PS50084
Domain-

PAK2 PAK3

2.55e-031211923.90.810.10
DomainPDZ

SHANK1 PREX2 LMO7 DLG2 SNTB1

2.59e-031481195SM00228
Domain-

SHANK1 PREX2 LMO7 DLG2 SNTB1

2.74e-0315011952.30.42.10
DomainKH_dom_type_1

MEX3D MEX3C MEX3A

2.76e-03441193IPR004088
DomainConA-like_dom

COL12A1 CLGN TRIM25 FAT3 LGALS4 COL14A1

2.81e-032191196IPR013320
DomainPDZ

SHANK1 PREX2 LMO7 DLG2 SNTB1

2.82e-031511195PS50106
DomainPDZ

SHANK1 PREX2 LMO7 DLG2 SNTB1

2.90e-031521195IPR001478
DomainOTU

OTUD6A OTUD6B

3.00e-03131192PF02338
Domain-

COL12A1 CLGN FAT3 LGALS4

3.19e-039511942.60.120.200
DomainOTU

OTUD6A OTUD6B

4.00e-03151192PS50802
DomainOTU_dom

OTUD6A OTUD6B

4.00e-03151192IPR003323
DomainPBD

PAK2 PAK3

4.56e-03161192SM00285
DomainC345C

C4A C4B

5.14e-03171192SM00643
DomainPBD

PAK2 PAK3

5.14e-03171192PF00786
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

5.76e-03181192IPR008930
DomainLaminin_G

COL12A1 FAT3 COL14A1

6.03e-03581193IPR001791
PathwayBIOCARTA_DICER_PATHWAY

AGO2 AGO1 AGO4 AGO3

6.43e-095864M22079
PathwayREACTOME_MICRORNA_MIRNA_BIOGENESIS

AGO2 POLR2E AGO1 AGO4 AGO3 DROSHA

6.97e-0925866M712
PathwayREACTOME_MICRORNA_MIRNA_BIOGENESIS

AGO2 AGO1 AGO4 AGO3

1.92e-086864MM14818
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

AGO2 AGO1 AGO4 AGO3

1.92e-086864MM15083
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

AGO2 AGO1 AGO4 AGO3

4.46e-087864M46421
PathwayREACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS

AGO2 AGO1 AGO4 AGO3

8.87e-088864MM15082
PathwayREACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS

AGO2 AGO1 AGO4 AGO3

1.59e-079864M27340
PathwayREACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION

AGO2 AGO1 AGO4 AGO3

1.59e-079864M27810
PathwayREACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION

AGO2 AGO1 AGO4 AGO3

1.59e-079864M46436
PathwayREACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS

AGO2 AGO1 AGO4 AGO3

2.64e-0710864M48013
PathwayREACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION

AGO2 AGO1 AGO4 AGO3

8.85e-0713864M46434
PathwayREACTOME_MAPK6_MAPK4_SIGNALING

AGO2 PSMD7 AGO1 AGO4 AGO3 PAK2 PAK3

1.52e-0693867M27572
PathwayREACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY

AGO2 AGO1 AGO4 AGO3

2.89e-0617864M27788
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS

AGO2 AGO1 AGO4 AGO3

4.67e-0619864M48238
PathwayREACTOME_TGFBR3_EXPRESSION

AGO2 AGO1 AGO4 AGO3

2.36e-0528864M48253
PathwayREACTOME_CA2_PATHWAY

AGO2 ITPR2 AGO1 AGO4 AGO3

3.70e-0562865M27321
PathwayREACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION

AGO2 AGO1 AGO4 AGO3

4.08e-0532864M48012
PathwayREACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY

AGO2 AGO1 AGO4 AGO3

4.08e-0532864M27900
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4

AGO2 AGO1 AGO4 AGO3

5.21e-0534864M46422
PathwayREACTOME_NUCLEAR_EVENTS_STIMULATED_BY_ALK_SIGNALING_IN_CANCER

AGO2 AGO1 AGO4 AGO3

5.85e-0535864M42525
PathwayREACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX

AGO2 AGO1 AGO4 AGO3

7.31e-0537864M29790
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

AGO2 PSMD7 ITGB3 AGO1 AGO4 AGO3 PAK2 PAK3 DLG2

1.67e-04327869M27565
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

AGO2 AGO1 AGO4 AGO3

1.89e-0447864M29777
PathwayREACTOME_PTEN_REGULATION

AGO2 PSMD7 PREX2 AGO1 AGO4 AGO3

2.03e-04139866M27646
PathwayREACTOME_GENE_SILENCING_BY_RNA

AGO2 POLR2E AGO1 AGO4 AGO3 DROSHA

2.03e-04139866M715
PathwayREACTOME_GENE_SILENCING_BY_RNA

AGO2 AGO1 AGO4 AGO3

2.22e-0449864MM14837
PathwayREACTOME_SIGNALING_BY_TGFBR3

AGO2 AGO1 AGO4 AGO3

2.22e-0449864M48250
PathwayREACTOME_SIGNALING_BY_ALK_IN_CANCER

AGO2 AGO1 AGO4 AGO3 LMO7

2.56e-0493865M42521
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

AGO2 PSMD7 ITPR2 AGO1 AGO4 AGO3

2.65e-04146866M27288
PathwayREACTOME_ADHERENS_JUNCTIONS_INTERACTIONS

AGO2 AGO1 AGO4 AGO3

4.26e-0458864M11980
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

AGO2 ITGB3 AGO1 AGO4 AGO3 SMAD6

4.47e-04161866M27871
PathwayREACTOME_SIGNALING_BY_VEGF

NCF4 ITGB3 ITPR2 PAK2 PAK3

4.70e-04106865M27077
PathwayWP_EXRNA_MECHANISM_OF_ACTION_AND_BIOGENESIS

AGO2 DROSHA

5.43e-046862M39578
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR2 P2RX7 ATP2B3

5.77e-0427863MM15053
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2

AGO2 AGO1 AGO4 AGO3

5.85e-0463864M27862
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR2 P2RX7 ATP2B3

6.43e-0428863M924
PathwayREACTOME_ACTIVATION_OF_C3_AND_C5

C4A C4B

7.57e-047862MM14685
PathwayREACTOME_RAC1_GTPASE_CYCLE

ARHGAP42 NCF4 PREX2 PAK2 PAK3 TMPO

9.03e-04184866M41809
PathwayKEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION

C4A C4B

1.01e-038862M47872
PathwayREACTOME_ACTIVATION_OF_C3_AND_C5

C4A C4B

1.01e-038862M27031
PathwayREACTOME_ONCOGENE_INDUCED_SENESCENCE

AGO1 AGO4 AGO3

1.25e-0335863M27190
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

FBXW9 ICAM4 REL NCF4 PSMD7 MEX3C ITPR2 CD22 LMO7 PAK2 PAK3 SIGLEC11

1.34e-037198612MM14540
PathwayWP_GENETIC_CAUSES_OF_PORTOSINUSOIDAL_VASCULAR_DISEASE

NCF4 C4orf54 GTF2I

1.47e-0337863M45513
PathwayWP_PYRIMIDINE_METABOLISM

CMPK1 POLR3H POLR2E UCK1

1.72e-0384864M48340
PathwayREACTOME_TP53_REGULATES_METABOLIC_GENES

AGO2 AGO1 AGO4 AGO3

1.72e-0384864M27495
Pubmed

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.

AGO2 MEX3D MEX3C MEX3A AGO1

3.31e-126125517267406
Pubmed

Molecular dissection of human Argonaute proteins by DNA shuffling.

AGO2 AGO1 AGO4 AGO3

1.59e-104125423748378
Pubmed

Slicing-independent RISC activation requires the argonaute PAZ domain.

AGO2 AGO1 AGO4 AGO3

1.59e-104125422795694
Pubmed

Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.

AGO2 AGO1 AGO4 AGO3

1.59e-104125418771919
Pubmed

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.

AGO2 AGO1 AGO4 AGO3

1.59e-104125415260970
Pubmed

ATP-dependent human RISC assembly pathways.

AGO2 AGO1 AGO4 AGO3

1.59e-104125419966796
Pubmed

Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.

AGO2 AGO1 AGO4 AGO3

7.93e-105125419393748
Pubmed

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.

AGO2 AGO1 AGO4 AGO3

7.93e-105125412414724
Pubmed

The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.

AGO2 AGO1 AGO4 AGO3

7.93e-105125419324964
Pubmed

Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.

AGO2 AGO1 AGO4 AGO3

7.93e-105125412526743
Pubmed

Differential expression of components of the microRNA machinery during mouse organogenesis.

AGO2 AGO1 AGO4 AGO3

7.93e-105125416036130
Pubmed

Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs.

AGO2 AGO1 AGO4 AGO3 DROSHA

2.34e-0916125520102707
Pubmed

Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development.

AGO2 AGO1 AGO4 AGO3

5.52e-097125434907157
Pubmed

Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.

AGO2 AGO1 AGO4 AGO3

5.52e-097125419536157
Pubmed

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.

AGO2 AGO1 AGO4 AGO3

5.52e-097125419383768
Pubmed

Functional dissection of the human TNRC6 (GW182-related) family of proteins.

AGO2 AGO1 AGO4 AGO3

5.52e-097125419470757
Pubmed

Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis.

AGO2 AGO1 AGO4 AGO3

1.10e-088125419345100
Pubmed

Suppression of microRNA Activity in Kidney Collecting Ducts Induces Partial Loss of Epithelial Phenotype and Renal Fibrosis.

AGO2 AGO1 AGO4 AGO3

1.10e-088125429021386
Pubmed

Identification of eight members of the Argonaute family in the human genome.

AGO2 AGO1 AGO4 AGO3

1.98e-089125412906857
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

AGO2 TRIM25 GAS2L3 VWA8 AHCTF1 COBLL1 NAP1L1 SHMT2 MEX3C KNOP1 GTF2I AGO3 LMO7 P4HA1 DROSHA TMPO COL14A1 C4B HADHA TALDO1 PHF10

1.99e-0813711252136244648
Pubmed

Turning catalytically inactive human Argonaute proteins into active slicer enzymes.

AGO2 AGO1 AGO3

4.53e-083125323665583
Pubmed

The roles of individual mammalian argonautes in RNA interference in vivo.

AGO2 AGO1 AGO3

4.53e-083125324992693
Pubmed

Argonaute2 is the catalytic engine of mammalian RNAi.

AGO2 AGO1 AGO3

4.53e-083125315284456
Pubmed

Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins.

AGO2 AGO1 AGO4

4.53e-083125319946268
Pubmed

Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules.

MEX3D MEX3C MEX3A AGO1

7.70e-0812125418779327
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SHANK1 ENPP2 CKAP5 NAP1L1 PSMD7 ADAMTS8 BRWD3 BFSP1 SCYL2 TTLL12 GUF1 NSMF LMO7 DROSHA PAK2 DLG2 KIFC3 UAP1L1 ZNF292

1.75e-0712851251935914814
Pubmed

Argonaute proteins: potential biomarkers for human colon cancer.

AGO2 AGO4 AGO3

1.81e-074125320146808
Pubmed

Argonaute, Dicer, and Drosha are up-regulated along tumor progression in serous ovarian carcinoma.

AGO2 AGO1 DROSHA

1.81e-074125322647351
Pubmed

A Requirement for Argonaute 4 in Mammalian Antiviral Defense.

AGO1 AGO4 AGO3

1.81e-074125332049003
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

AGO2 TRIM25 ICE2 CAST CKAP5 MEX3A AGO1 AGO3 LMO7 PAK2 HADHA NNT PHF10 ZNF292

3.70e-077241251436232890
Pubmed

Quantitative functions of Argonaute proteins in mammalian development.

AGO2 AGO1 AGO3

4.51e-075125322474261
Pubmed

Upregulation of Cyclin B1 by miRNA and its implications in cancer.

AGO2 AGO1 DROSHA

8.99e-076125322053081
Pubmed

Mitochondrial Raf1 Regulates Glutamine Catabolism.

SAMD9 CAST SHMT2 ITGB3 LGALS4 TTLL12 MRPS30 HADHA UAP1L1

1.07e-06288125938496616
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

PDS5B CMPK1 AHCTF1 POLR2E NAP1L1 SHMT2 PSMD7 DNTTIP2 KNOP1 YEATS2 GUF1 GTF2I P4HA1 PAK2 TMPO CRYBG1 HADHA TALDO1

1.20e-0613181251830463901
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

TRIM25 AHCTF1 CAST CKAP5 NAP1L1 SHMT2 PSMD7 DNTTIP2 KNOP1 SCYL2 YEATS2 NEK1 GTF2I PAK2 TMPO

1.42e-069341251533916271
Pubmed

Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins.

AGO2 AGO1 AGO3

1.57e-067125328683311
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

PDS5B NAT9 PSMD7 LOXHD1 LMO7 P4HA1 TMPO C4A C4B NACA4P ZNF292

1.95e-064971251136774506
Pubmed

Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes.

AGO2 AGO1 DROSHA

2.50e-068125320211803
Pubmed

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.

CMPK1 AGO2 GAS2L3 MEX3D CKAP5 NAP1L1 PSMD7 MEX3C ITPR2 AGO1 P4HA1 C4A TALDO1

2.52e-067321251334732716
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

CLGN MEX3D BFSP1 MEX3C SCYL2 IGSF10 MEX3A

2.68e-06168125730631154
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

TRIM25 CAST CKAP5 NAP1L1 TTLL12 GTF2I LMO7 P4HA1 TMPO

3.42e-06332125932786267
Pubmed

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis.

AGO2 AGO1 DROSHA

3.75e-069125320424607
Pubmed

MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.

TRIM25 CAST NAP1L1 TTLL12 PAK2 TMPO HADHA

4.54e-06182125730711629
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

AGO2 AHCTF1 CAST NAP1L1 SCYL2 YEATS2 NEK1 GTF2I LMO7 PAK2 TMPO

5.03e-065491251138280479
Pubmed

Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.

AGO2 AGO1 DROSHA

5.34e-0610125320721975
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

TRIM25 SPRR3 COBLL1 CAST CKAP5 SCYL2 LMO7 PAK2 TMPO CRYBG1 N4BP1

6.60e-065651251125468996
Pubmed

HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.

AGO2 AGO1 AGO3

7.32e-0611125322915799
Pubmed

Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture.

BFSP1 PAK2 PAK3

9.74e-0612125318824165
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

1.28e-052125222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

1.28e-052125216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

1.28e-052125215998580
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

1.28e-052125219062096
Pubmed

Collagen types XII and XIV are present in basement membrane zones during human embryonic development.

COL12A1 COL14A1

1.28e-052125215609093
Pubmed

Alternative splicing and promoter use in TFII-I genes.

GTF2IRD1 GTF2I

1.28e-052125219111598
Pubmed

Reduced Expression of Argonaute 1, Argonaute 2, and TRBP Changes Levels and Intracellular Distribution of RNAi Factors.

AGO2 AGO1

1.28e-052125226242502
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

1.28e-052125219933335
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

1.28e-05212522459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

1.28e-052125217645767
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

1.28e-052125212207352
Pubmed

Germline loss-of-function SAMD9 and SAMD9L alterations in adult myelodysplastic syndromes.

SAMD9 SAMD9L

1.28e-052125230322869
Pubmed

The Importance of AGO 1 and 4 in Post-Transcriptional Gene Regulatory Function of tRF5-GluCTC, an Respiratory Syncytial Virus-Induced tRNA-Derived RNA Fragment.

AGO1 AGO4

1.28e-052125233233493
Pubmed

Essential functions of the Williams-Beuren syndrome-associated TFII-I genes in embryonic development.

GTF2IRD1 GTF2I

1.28e-052125219109438
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

1.28e-052125227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

1.28e-052125222387014
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

1.28e-052125223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

1.28e-052125223918728
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

1.28e-05212523037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

1.28e-052125211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

1.28e-05212524216347
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

1.28e-05212526950384
Pubmed

Partial 7q11.23 deletions further implicate GTF2I and GTF2IRD1 as the main genes responsible for the Williams-Beuren syndrome neurocognitive profile.

GTF2IRD1 GTF2I

1.28e-052125219897463
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

1.28e-05212528660986
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

1.28e-05212528428773
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

1.28e-052125224638111
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

1.28e-052125221345967
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

1.28e-05212522572548
Pubmed

The complement component C4 of mammals.

C4A C4B

1.28e-05212522302180
Pubmed

SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies.

SAMD9 SAMD9L

1.28e-052125229535429
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

1.28e-052125222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

1.28e-052125218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

1.28e-052125229080553
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

1.28e-05212526589636
Pubmed

Regulation of immunoglobulin promoter activity by TFII-I class transcription factors.

GTF2IRD1 GTF2I

1.28e-052125214645227
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

1.28e-052125225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

1.28e-052125217728371
Pubmed

Involvement of AGO1 and AGO2 in mammalian transcriptional silencing.

AGO2 AGO1

1.28e-052125216936728
Pubmed

Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes.

SAMD9 SAMD9L

1.28e-052125234621053
Pubmed

Structure and organization of the C4 genes.

C4A C4B

1.28e-05212526149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

1.28e-05212526149581
Pubmed

Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression.

AGO2 AGO1

1.28e-052125210534406
Pubmed

Duplication of GTF2I results in separation anxiety in mice and humans.

GTF2IRD1 GTF2I

1.28e-052125222578324
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

1.28e-052125212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

1.28e-05212523542363
Pubmed

Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.

SAMD9 SAMD9L

1.28e-052125233731850
Pubmed

Argonaute Family Protein Expression in Normal Tissue and Cancer Entities.

AGO2 AGO1

1.28e-052125227518285
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

1.28e-05212522387317
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

1.28e-052125216908004
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

1.28e-05212527365238
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

1.28e-05212527391573
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

1.28e-052125217971360
InteractionTDRD1 interactions

AGO2 AGO1 AGO4 AGO3

4.62e-06191224int:TDRD1
Cytoband10p11.2

ZEB1 ZNF37A

2.00e-048124210p11.2
Cytoband7q21.2

SAMD9 SAMD9L

7.43e-041512427q21.2
CytobandEnsembl 112 genes in cytogenetic band chr12q23

GAS2L3 APAF1 SCYL2 TMPO

7.58e-041501244chr12q23
Cytoband8q23

PKHD1L1 COL14A1

1.08e-031812428q23
Cytoband4q23

C4orf54 ADH5

1.33e-032012424q23
Cytoband4p12

ATP10D GUF1

1.33e-032012424p12
CytobandEnsembl 112 genes in cytogenetic band chr4p12

ATP10D GUF1

2.25e-03261242chr4p12
CytobandEnsembl 112 genes in cytogenetic band chr6q14

COL12A1 CYB5R4 ZNF292

2.36e-03971243chr6q14
Cytoband3p22.3

SUSD5 OSBPL10

3.20e-033112423p22.3
Cytoband1p34

AGO4 AGO3

3.40e-033212421p34
CytobandEnsembl 112 genes in cytogenetic band chr5p12

MRPS30 NNT

3.40e-03321242chr5p12
Cytoband12q23.1

GAS2L3 SCYL2

3.62e-0333124212q23.1
Cytoband16p12.3

KNOP1 IQCK

3.84e-0334124216p12.3
CytobandEnsembl 112 genes in cytogenetic band chr4q23

C4orf54 ADH5

4.53e-03371242chr4q23
GeneFamilyArgonaute/PIWI family

AGO2 AGO1 AGO4 AGO3

2.58e-088814408
GeneFamilyPDZ domain containing

SHANK1 PREX2 LMO7 DLG2 SNTB1

6.03e-041528151220
GeneFamilyGlycosyltransferase family 6|Blood group antigens

ICAM4 C4A C4B

6.03e-0437813454
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

6.99e-0498121234
GeneFamilyOTU domain containing

OTUD6A OTUD6B

2.58e-0317812669
CoexpressionGSE3982_DC_VS_MAC_LPS_STIM_DN

TRIM25 VWA8 MEX3D ICAM4 NCF4 CPE P2RX7 NNT

4.97e-061991248M5390
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#5_top-relative-expression-ranked_1000

GAS2L3 ENPP2 APAF1 BRWD3 MRPS30 YEATS2 NEK1 AGO4 AGO3 HMCN1 LMO7 PAK3 TMPO

3.49e-0647812113gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000_k5
CoexpressionAtlasdev gonad_e13.5_F_SupCellPrec_Sry_top-relative-expression-ranked_500

ARHGAP42 BOC COL12A1 ENPP2 CPE ITPR2 SCYL2 HMCN1 LMO7 HADHA ATP2B3

3.02e-0542212111gudmap_dev gonad_e13.5_F_SupCellPrec_Sry_500
CoexpressionAtlaskidney_adult_RenalCapsule_top-relative-expression-ranked_1000

BOC COL12A1 FAT3 COBLL1 CAST CPE CREB3L1 ATP10D SAMD9L HMCN1 LMO7 P4HA1 VWA5A COL14A1 C4B

3.68e-0577812115gudmap_kidney_adult_RenalCapsule_1000
CoexpressionAtlasdev gonad_e13.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000

ARHGAP42 BOC COL12A1 ENPP2 ICE2 CPE MEX3C KNOP1 ITPR2 SCYL2 YEATS2 HMCN1 LMO7 HADHA ATP2B3

5.34e-0580412115gudmap_dev gonad_e13.5_F_SupCellPrec_Sry_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_1000

ARHGAP42 BOC COL12A1 ENPP2 FAT3 CREB3L1 MEX3C ITPR2 SCYL2 IGSF10 HMCN1 COL14A1 HADHA ATP2B3

8.32e-0574012114gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_top-relative-expression-ranked_1000

CLGN GAS2L3 ENPP2 APAF1 BRWD3 MRPS30 YEATS2 NEK1 AGO4 AGO3 HMCN1 LMO7 PAK3 TMPO COL14A1

9.96e-0585012115gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000
CoexpressionAtlaskidney_adult_RenalCapsule_top-relative-expression-ranked_500

BOC COL12A1 COBLL1 CPE CREB3L1 SAMD9L HMCN1 LMO7 VWA5A COL14A1

1.17e-0440812110gudmap_kidney_adult_RenalCapsule_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_1000_k-means-cluster#5

AGO2 ICE2 NCF4 GTF2IRD1 PREX2 ITPR2 ADH5 IGSF10 VWA5A

1.19e-043311219Facebase_RNAseq_e10.5_Mandibular Arch_1000_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#1

AGO2 NCF4 GTF2IRD1 PREX2 ITPR2 ADH5

1.35e-041371216Facebase_RNAseq_e10.5_Mandibular Arch_500_K1
CoexpressionAtlasdev gonad_e12.5_F_VasAssMesen_MafB_top-relative-expression-ranked_1000

ARHGAP42 BOC COL12A1 ICE2 FAT3 CREB3L1 MEX3C ITPR2 SCYL2 IGSF10 YEATS2 HMCN1 HADHA ATP2B3

1.50e-0478312114gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_1000
CoexpressionAtlasdev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#1_top-relative-expression-ranked_100

FAT3 HMCN1 COL14A1

1.64e-04191213gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k1_100
CoexpressionAtlasdev gonad_e12.5_F_VasAssocMesStromOvary_Sma_top-relative-expression-ranked_1000

ARHGAP42 BOC COL12A1 FAT3 CPE CREB3L1 ATP10D MEX3C ITPR2 SCYL2 IGSF10 HMCN1 HADHA ATP2B3

1.81e-0479712114gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_1000
CoexpressionAtlasdev gonad_e12.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000

ARHGAP42 BOC COL12A1 VWA8 ICE2 CPE MEX3C KNOP1 ITPR2 SCYL2 HMCN1 LMO7 HADHA ATP2B3

1.95e-0480312114gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_1000
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_top-relative-expression-ranked_1000

ARHGAP42 COL12A1 AGO2 ENPP2 FAT3 COBLL1 CPE ADAMTS8 ITGB3 OR51E1 SAMD9L LMO7 PAX8 KCNJ1 CYB5R4

1.98e-0490512115gudmap_kidney_P0_JuxtaGlom_Ren1_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_500

BOC COL12A1 ENPP2 CREB3L1 ITPR2 SCYL2 IGSF10 HMCN1 ATP2B3

2.10e-043571219gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_500
CoexpressionAtlasfacebase_RNAseq_e10.5_MandArch_2500

ARHGAP42 ZEB1 ENPP2 ICE2 AHCTF1 CKAP5 CPE PREX2 BRWD3 DNTTIP2 ITPR2 ADH5 MRPS30 IGSF10 OR51E1 PLCL2 TMPO PHF10 IQCK ZNF292

2.31e-04146812120facebase_RNAseq_e10.5_MandArch_2500
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL12A1 GAS2L3 COBLL1 CPE GTF2IRD1 ARHGEF10L PAX8 OSBPL10 SNTB1

2.16e-0918112499d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL12A1 GAS2L3 COBLL1 CPE GTF2IRD1 ARHGEF10L PAX8 OSBPL10 SNTB1

2.26e-091821249eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAST CKAP5 CPE IGSF10 HMCN1 P4HA1 COL14A1 HADHA

3.50e-081761248749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BOC FAT3 CPE ARHGEF10L PAX8 TMEM132D OSBPL10 SNTB1

4.73e-08183124892fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCellTracheal-10x3prime_v2-Stromal-Mesofibroblastic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRIM25 SGCA FAT3 ADAMTS8 ARHGEF10L HMCN1 ZNF37A COL14A1

8.36e-081971248d7cef7881abd807a679432766ced609a6efd1067
ToppCellTracheal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRIM25 SGCA FAT3 ADAMTS8 ARHGEF10L HMCN1 ZNF37A COL14A1

8.36e-08197124820a5958512bdb99daeb8f4d244df53e4f048f879
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 C4orf54 PAX8 PLCL2 CRYBG1 DLG2 KIFC3

5.04e-071701247928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BOC FAT3 CPE ARHGEF10L PAX8 TMEM132D SNTB1

7.69e-071811247071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BOC FAT3 CPE ARHGEF10L PAX8 TMEM132D SNTB1

8.28e-071831247738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

PREX2 ATP10D ITPR2 NEK1 HMCN1 DLG2 COL14A1

8.58e-07184124767164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 CPE PAX8 TMEM132D OSBPL10 COL14A1 SNTB1

9.23e-071861247f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BOC COBLL1 CPE GTF2IRD1 ARHGEF10L PAX8 OSBPL10

9.57e-071871247c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT3 COBLL1 CPE PAX8 TMEM132D OSBPL10 SNTB1

1.10e-061911247d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

ENPP2 FAT3 NAP1L1 ADAMTS8 HMCN1 DLG2 KIFC3

1.14e-06192124762904f94dfce430456f05066522cbf9bd29f4d7e
ToppCellMatrixFB-Fibroblast-B_(Myofibroblast)|MatrixFB / shred on cell class and cell subclass (v4)

ARHGAP42 ZEB1 COL12A1 ENPP2 ADAMTS8 MEX3A HMCN1

1.31e-06196124738ea0eaf42f95c321ca23570d0d7752980cf00f8
ToppCellmLN-(2)_B_cell-(22)_B_cell_memory|mLN / shred on region, Cell_type, and subtype

COBLL1 REL NCF4 PKHD1L1 CD22 OSBPL10 MNDA

1.40e-0619812474d189df1db5b41306e9653436d7d7e75ff5afa06
ToppCellmLN-B_cell-B_cell_memory|mLN / Region, Cell class and subclass

COBLL1 REL NCF4 PKHD1L1 CD22 OSBPL10 MNDA

1.40e-0619812476dc155ee487abb1319a60a7a70e84c28c9851985
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ZEB1 COL12A1 ENPP2 EPB41L4A PREX2 AGO4 HMCN1

1.50e-062001247dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_and_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

ARHGAP42 COL12A1 ITGB3 HMCN1 COL14A1 OCSTAMP

3.86e-0614912463904f8ce9078de238600ceceee0116af52256a1c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related-Oligodendrocyte/OPC|GW10 / Sample Type, Dataset, Time_group, and Cell type.

PREX2 HMCN1 P2RX7 PAX8 UAP1L1 SMAD6

4.17e-0615112464533bccc996395f74b16af939ce79b6fe253c073
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related|GW10 / Sample Type, Dataset, Time_group, and Cell type.

PREX2 HMCN1 P2RX7 PAX8 UAP1L1 SMAD6

4.17e-061511246edb2f59789c295838d2030b80c792cbea25eaa3d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BOC ZEB1 CLGN PKHD1L1 PREX2 SMAD6

5.61e-061591246d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL12A1 CPE GTF2IRD1 PAX8 COL14A1 SNTB1

6.70e-061641246382e42701779d12a7948690b3be72d06dd75c8b4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BOC CPE PREX2 ARHGEF10L PAX8 SNTB1

8.23e-0617012465d5f208682be21ed58320f5fc083a7898f8712da
ToppCell10x5'-Lung-Lymphocytic_B-Memory_B_cells|Lung / Manually curated celltypes from each tissue

BOC SGCA COBLL1 PKHD1L1 CD22 OSBPL10

8.80e-0617212462cb2dc7cfd6db5a98a393b1a84c23abf3d692a53
ToppCellfacs-Trachea-24m-Hematologic-myeloid|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLAMF8 TRIM25 GAS2L3 REL NCF4 TALDO1

9.39e-0617412462f25fba5225f4687df4396645e94565a640b5583
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage|343B / Donor, Lineage, Cell class and subclass (all cells)

GAS2L3 SLC36A4 N4BP1 SIGLEC11 CYB5R4 MNDA

9.71e-061751246d3890bd0c570bb81434fdd1c5229891cefe2e462
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BOC FAT3 CPE PAX8 TMEM132D SNTB1

1.00e-051761246327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BOC FAT3 CPE PAX8 TMEM132D SNTB1

1.04e-051771246da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

REL PREX2 SAMD9L LMO7 PAK2 N4BP1

1.07e-05178124601dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 GTF2IRD1 BFSP1 KCNJ1 COL14A1 SNTB1

1.29e-051841246d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BOC FAT3 CPE PAX8 TMEM132D SNTB1

1.29e-051841246da06ff24ee2b2cf4715fdfce43030b2da9e0aaf8
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 C4orf54 PAX8 PLCL2 CRYBG1 DLG2

1.33e-051851246d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKHD1L1 PREX2 ITPR2 SAMD9L HMCN1 LMO7

1.37e-0518612460ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellCOVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

ZEB1 CPE EPB41L4A PKHD1L1 PREX2 SMAD6

1.41e-0518712462d20193a6cacdfa4877457c97b0077408942186c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 PAX8 PLCL2 CRYBG1 DLG2 IQCK

1.41e-051871246e3095455d2f255854f339f6b05fa87852af0700f
ToppCellfacs-MAT-Fat-3m|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC CPE IGSF10 P4HA1 VWA5A COL14A1

1.46e-0518812467da9750255efbc5cf9aed7e3105a337fac63b9f0
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BOC FAT3 CPE PAX8 TMEM132D SNTB1

1.50e-051891246904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ENPP2 FAT3 PREX2 IGSF10 HMCN1 COL14A1

1.50e-051891246203c80030df08ae112f9ae4043709f455d87ce89
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

ZEB1 EPB41L4A PKHD1L1 ITPR2 HMCN1 SMAD6

1.50e-051891246c81787a8c662db5d7814c583dd64562857629e81
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BOC COBLL1 CPE ARHGEF10L PAX8 OSBPL10

1.55e-0519012461cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell390C-Lymphocytic-B_cell-|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

COBLL1 NCF4 PKHD1L1 CD22 OSBPL10 MNDA

1.55e-051901246f63c9474f23bb72f0bb1fc531342f0da04ed8b3e
ToppCell(5)_Fibroblasts-(5)_Fibroblast-C_(Myofibroblast)|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

SGCA ENPP2 FAT3 NAP1L1 HMCN1 COL14A1

1.55e-05190124671e112dfb8c3190fe0286b45a046ea789eb6a8db
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-intestinal_crypt_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BOC NAP1L1 SHMT2 ADH5 MRPS30 TMPO

1.55e-051901246c0ee404d705b0b4f0c6ded4d070ad85eac4b16db
ToppCell390C-Lymphocytic-B_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

COBLL1 NCF4 PKHD1L1 CD22 OSBPL10 MNDA

1.55e-05190124653bf211f0e8a44f5adb89c43b210a1e35120b6a8
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARHGAP42 COL12A1 SGCA CPE HMCN1 COL14A1

1.55e-051901246d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAST BRWD3 ITPR2 SAMD9L PAK2 CYB5R4

1.59e-05191124660c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

BOC SGCA COBLL1 NCF4 CD22 OSBPL10

1.59e-0519112466a8b0987e75456a257954288206da0032605ff2a
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAST BRWD3 ITPR2 SAMD9L PAK2 CYB5R4

1.59e-051911246973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 CPE IGSF10 HMCN1 MNDA

1.62e-051131245ec4b89e727e1b921b9cb17443774955b95814dd4
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

BOC COL12A1 CPE CREB3L1 IGSF10 COL14A1

1.64e-0519212468d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BOC CREB3L1 IGSF10 DLG2 COL14A1 C4B

1.64e-051921246c3707243c5590d852c9f28429c96f50a1fa6b0dc
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

BOC ZEB1 ENPP2 CPE ITPR2 SUSD5

1.64e-051921246d0649410cf5eacdb0c1dce70e37c7473ef5fddfa
ToppCelldroplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SHANK1 BOC ADAMTS8 CREB3L1 IGSF10 C4B

1.64e-0519212461b228f0929b505de82a39bf64c837887b0e56701
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BOC CREB3L1 IGSF10 DLG2 COL14A1 C4B

1.64e-051921246f9fb24457999dc9e751a099d7f995543b9330ad4
ToppCellMesenchymal-matrix_fibroblast_2_cell|World / Lineage, Cell type, age group and donor

BOC COL12A1 CPE IGSF10 PAK3 COL14A1

1.64e-051921246a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D122|Adult / Lineage, Cell type, age group and donor

GAS2L3 NCF4 ARHGEF10L P2RX7 UAP1L1 SNTB1

1.69e-051931246cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

BOC ZEB1 COL12A1 HMCN1 DLG2 COL14A1

1.69e-051931246e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 GTF2IRD1 ARHGEF10L LMO7 PAX8 KIFC3

1.69e-0519312463866667dd221612589ae50f5c52f73a183a49ce6
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

BOC SGCA COBLL1 NCF4 CD22 OSBPL10

1.69e-051931246437ae3b10d169bb371f7b92d57a77f43e3f8d64d
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

SAMD9 REL SAMD9L CRYBG1 N4BP1 ZNF292

1.69e-0519312467256a5a491536c525b31ae96d47ab5c6303cb73a
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

BOC SGCA COBLL1 NCF4 CD22 OSBPL10

1.69e-05193124694b5a4a4e9faaa95cb72907a2f0497429c72e516
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BOC COL12A1 CPE PREX2 PAK3 COL14A1

1.74e-051941246c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_B-B_cell|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

COBLL1 REL NCF4 PKHD1L1 CD22 OSBPL10

1.74e-0519412461b9ec27cdd52a54b55e4ad89162e8a170d57c017
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL12A1 SGCA CPE OR51E1 SUSD5 COL14A1

1.79e-051951246e10b21e4dba4483efc4c82d6e395524246ca14a8
ToppCellfacs-Bladder-nan-3m-Epithelial-bladder_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZEB1 COL12A1 ENPP2 CREB3L1 IGSF10 COL14A1

1.79e-051951246223f5f07dc28fa13a09bb589884c58043c7928c7
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 GTF2IRD1 ARHGEF10L LMO7 PAX8 KIFC3

1.79e-0519512466477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BOC COL12A1 CPE PREX2 PAK3 COL14A1

1.79e-0519512463c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCellFibroblast-B_(Myofibroblast)|World / shred on cell class and cell subclass (v4)

ARHGAP42 COL12A1 ENPP2 ADAMTS8 MEX3A HMCN1

1.79e-051951246a8d6416518f226e1ec2d6bdc9d4b90cef5cb1365
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SGCA ENPP2 FAT3 NAP1L1 ADAMTS8 HMCN1

1.85e-0519612466730743cf088c419ccc2d28765769fc09d3ba6a7
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SGCA ENPP2 FAT3 NAP1L1 ADAMTS8 HMCN1

1.85e-05196124621dab89f3699037138a9c7a0e4dc98739a9fad9c
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SGCA FAT3 ADAMTS8 IGSF10 HMCN1 COL14A1

1.85e-05196124642e9828222a9663525d571633e8a454c30bfa7f8
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 GTF2IRD1 ARHGEF10L LMO7 PAX8 KIFC3

1.85e-0519612466ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCellChildren_(3_yrs)-Mesenchymal|Children_(3_yrs) / Lineage, Cell type, age group and donor

BOC FAT3 ADAMTS8 IGSF10 HMCN1 COL14A1

1.85e-051961246bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL12A1 SGCA CPE ADAMTS8 SUSD5 COL14A1

1.85e-051961246208ddedd29e1b9ca89cbb9b527c2e193a44cada2
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COBLL1 GTF2IRD1 ARHGEF10L LMO7 PAX8 KIFC3

1.85e-051961246eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL12A1 SGCA CPE OR51E1 SUSD5 COL14A1

1.90e-051971246d14e1f2ba94240c61eac435db43508a224d606a8
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ZEB1 CPE EPB41L4A PKHD1L1 PREX2 SMAD6

1.90e-051971246b0036cf3f7e6edf8e43f16cd2f0f0e80471d2576
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL12A1 SGCA CPE OR51E1 SUSD5 COL14A1

1.90e-05197124602e70768a917c5f097bc653e9e965a1000289d2e
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGAP42 COL12A1 ENPP2 ADAMTS8 MEX3A HMCN1

1.90e-0519712469d7a1c7dc70ba5e35645f19f9e056e4fa2494aa0
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGAP42 COL12A1 ENPP2 ADAMTS8 MEX3A HMCN1

1.90e-051971246090a251194da3e2806989d9a522588f83f52da7f
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGAP42 COL12A1 ENPP2 ADAMTS8 MEX3A HMCN1

1.90e-05197124643b5f8e917506c1717f9311584901b506ffd2c79
ToppCell11.5-Airway-Mesenchymal-Mesenchyme_SERPINF1-high|Airway / Age, Tissue, Lineage and Cell class

BOC ZEB1 COL12A1 CPE CREB3L1 COL14A1

1.90e-0519712469a053a32ff9c3a85ef9a3382453acd619cc48546
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)|367C / Donor, Lineage, Cell class and subclass (all cells)

SGCA FAT3 ADAMTS8 IGSF10 HMCN1 COL14A1

1.95e-051981246a9afedbc0556faf4a46f7bf28f4a9adb3bc859d8
ToppCellBronchus_Control_(B.)-Immune-TX-MoAM-3|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

SLAMF8 GAS2L3 ITGB3 P2RX7 CYB5R4 SNTB1

1.95e-0519812461d92b09aeb03a95fa9e221813002045c4f41dd24
ToppCell10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-early_osteoblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

COL12A1 ENPP2 FAT3 CPE CREB3L1 LMO7

1.95e-0519812466a539d3b47bd2d4a7ad5c67cad23facffc0ac45f
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL12A1 SGCA CPE OR51E1 SUSD5 COL14A1

1.95e-05198124654c8aa47040bc4977eed382514fc4ceae03f54f8
ToppCell(5)_Fibroblasts-(5)_Fibroblast-B_(Myofibroblast)|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

COL12A1 ENPP2 SPRR3 HMCN1 LMO7 COL14A1

1.95e-051981246196257c4420ac801ed9fbb444f11718adb7560ae
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL12A1 SGCA CPE OR51E1 SUSD5 COL14A1

1.95e-051981246daf367b699726286f0f0f7b4f3a6cf70c462fbeb
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|367C / Donor, Lineage, Cell class and subclass (all cells)

SGCA FAT3 ADAMTS8 IGSF10 HMCN1 COL14A1

1.95e-0519812467b5350768f306ec528e271d2ac4470bf668ec6f0
ToppCellproximal-mesenchymal-Alveolar_Fibroblast|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SGCA ENPP2 FAT3 ADAMTS8 IGSF10 HMCN1

2.01e-0519912467f4840ae6a888380feca722543e5e52783f3e35d
ToppCellproximal-3-mesenchymal-Alveolar_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SGCA ENPP2 FAT3 ADAMTS8 IGSF10 HMCN1

2.01e-051991246301d02bbb37e6f1d24b6e865bc3fe3e91260eb30
ToppCellproximal-mesenchymal-Alveolar_Fibroblast-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SGCA ENPP2 FAT3 ADAMTS8 IGSF10 HMCN1

2.01e-0519912469a16e519fb0651a7c4d8e05b931df4fb3b0eb3d1
ToppCellBiopsy_Control_(H.)-Mesenchymal-Mesothelial_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

SHANK1 BOC CPE PKHD1L1 C4A C4B

2.01e-051991246ca970114b5aef4518ce580897a62ac88688b2671
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-B_lymphocytic|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

COBLL1 REL NCF4 PKHD1L1 CD22 OSBPL10

2.01e-0519912461aa963ed5205d6d52262b1597a5d08707a95c3ca
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-early_osteoblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

COL12A1 ENPP2 FAT3 CPE CREB3L1 LMO7

2.07e-05200124616a7c398626b6e82b394eb3ef013bda3a788659d
ToppCellCOVID-19-COVID-19_Convalescent-Lymphocyte-B-B_intermediate|COVID-19_Convalescent / Disease, condition lineage and cell class

BOC SGCA COBLL1 NCF4 CD22 OSBPL10

2.07e-052001246fdc0df661a34e0db3279334bdeebfdf60c85ef41
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SLAMF8 GAS2L3 NCF4 ARHGEF10L SIGLEC11 MNDA

2.07e-0520012466e50272d172b491200d9a255ed08e6d6998cfe02
ToppCellLPS_IL1RA|World / Treatment groups by lineage, cell group, cell type

COL12A1 CAST ITGB3 P4HA1 PAK2 SMAD6

2.07e-052001246a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

COL12A1 ENPP2 FAT3 CPE CREB3L1 LMO7

2.07e-052001246780d47f8eff630020dfae32218de495a7e9dbad6
DrugThiethylperazine malate [52239-63-1]; Down 200; 6uM; HL60; HT_HG-U133A

IL12RB1 TRIM25 MEX3D LGALS4 KNOP1 ITPR2 CD22 SNTB1 IQCK

1.29e-0619912296154_DN
Drugcyclopentenyl uracil

CPE UCK1 TMEM132D

2.97e-0661223CID000128937
Drugdiphosphoethanolamine

ZEB1 GTF2IRD1 TMEM132D

8.24e-0681223CID000193703
DrugSulfamethoxazole [723-46-6]; Down 200; 15.8uM; MCF7; HT_HG-U133A

IL12RB1 ZEB1 SAMD9 COBLL1 BFSP1 SCYL2 KCNJ1 COL14A1

9.73e-0619312284690_DN
Drugsemustine; Down 200; 100uM; PC3; HT_HG-U133A

ZEB1 COBLL1 CREB3L1 NEK1 LMO7 PLCL2 NNT IQCK

1.01e-0519412287545_DN
DiseaseFamilial monosomy 7 syndrome

SAMD9 SAMD9L

1.70e-0521222cv:C5681220
DiseaseFuchs' endothelial dystrophy (is_implicated_in)

ZEB1 LOXHD1

2.52e-0461222DOID:11555 (is_implicated_in)
DiseasePARTINGTON X-LINKED MENTAL RETARDATION SYNDROME

BRWD3 PAK3

4.67e-0481222C0796250
DiseaseWilliams Syndrome

GTF2IRD1 GTF2I

4.67e-0481222C0175702
DiseaseColorectal Carcinoma

SHANK1 BOC AMDHD2 CPE PREX2 ARHGEF10L P2RX7 LMO7 PAX8 ZNF292

6.88e-0470212210C0009402
DiseaseAutistic Disorder

SHANK1 VWA8 ITGB3 AGO1 C4B ZNF292

7.77e-042611226C0004352
Diseaselate-onset Alzheimers disease

FAT3 CKAP5 TECTA HMCN1 KIFC3 IQCK

1.38e-032921226EFO_1001870
Diseasepulse pressure measurement, social deprivation

ADAMTS8 PLCL2

1.49e-03141222EFO_0005763, EFO_0009696
DiseaseWilliams-Beuren syndrome (implicated_via_orthology)

GTF2IRD1 GTF2I

1.72e-03151222DOID:1928 (implicated_via_orthology)
Diseaserheumatoid arthritis (is_implicated_in)

CAST NCF4 C4B

1.80e-03581223DOID:7148 (is_implicated_in)
Diseasesystemic lupus erythematosus (is_implicated_in)

CAST C4A C4B

2.18e-03621223DOID:9074 (is_implicated_in)
DiseaseAlzheimer disease, brain volume measurement

PDS5B PAK2

2.21e-03171222EFO_0006930, MONDO_0004975
Diseaseethylmalonate measurement

P2RX7 TMEM132D

3.07e-03201222EFO_0020009
Diseaseschizophrenia, intelligence, self reported educational attainment

SAMD9 FAT3 SHMT2 MRPS30 NEK1 PLCL2

3.22e-033461226EFO_0004337, EFO_0004784, MONDO_0005090
DiseaseParoxysmal atrial fibrillation

SGCA MEX3C GTF2I PAK2

4.07e-031561224C0235480
Diseasefamilial atrial fibrillation

SGCA MEX3C GTF2I PAK2

4.07e-031561224C3468561
DiseasePersistent atrial fibrillation

SGCA MEX3C GTF2I PAK2

4.07e-031561224C2585653

Protein segments in the cluster

PeptideGeneStartEntry
PKYVVPVESSLGKEK

APAF1

276

O14727
EISSLVPLGPKYVVK

ARHGEF10L

586

Q9HCE6
EKRTLIAEGYPIPTK

CREB3L1

266

Q96BA8
FEVKITPGKPYILTV

C4B

241

P0C0L5
TKLKAGDTVIPLYIP

ADH5

81

P11766
LTVPGEVFPPKVKYT

ADAMTS8

791

Q9UP79
IIVILPGKTPVYAEV

AGO1

516

Q9UL18
VKIVGIKYEVGPPTL

BRWD3

986

Q6RI45
VILPGKTPVYAEVKR

AGO3

521

Q9H9G7
VVILPGKTPVYAEVK

AGO4

511

Q9HCK5
KPSNEITREYIPKIG

COBLL1

716

Q53SF7
AYTTKILPPEKEGAL

ATP2B3

521

Q16720
TSAPPVIYGVLEKDV

ATP10D

1156

Q9P241
ILPGKTPVYAEVKRV

AGO2

521

Q9UKV8
GKITYPPGVKEISDK

PDS5B

11

Q9NTI5
KLEKPPKEGVYELAT

NIPSNAP3A

136

Q9UFN0
PKVATPKVVEKIGDY

PAX8

81

Q06710
EGYKVKQEPVITVAP

IQCK

71

Q8N0W5
ETPTGYIESLPRVVK

NAP1L1

61

P55209
VKAVDPKTGREIPYT

SHMT2

296

P34897
IVLVKVKDPTEYTGP

ITPR2

2596

Q14571
PDKSKVTEYLEPVVL

GUF1

461

Q8N442
RTIIIKGYVPPTGKS

LGALS4

206

P56470
PTLIIGEEYVKKPII

OTUD6A

241

Q7L8S5
PEVVTRKAYGPKVDI

PAK3

446

O75914
PDILVTGTYDKKVTI

FBXW9

276

Q5XUX1
KKVDIAGIYPPVTTP

HOGA1

31

Q86XE5
TIRSEISPEGEKYKP

NEK1

831

Q96PY6
VPVKYEVIVTTGYEP

LOXHD1

1946

Q8IVV2
PVLNPIVYGVKTKEI

OR51E1

286

Q8TCB6
PPVVNPIVYSIKTKE

OR51J1

286

Q9H342
IDPDVKPGEYVIKSL

FRYL

6

O94915
TYIKTPVRGEEPVFI

MEX3D

211

Q86XN8
LPTLPAKVYVGVKQE

NCF4

86

Q15080
VEEKGATYPSEIPKE

LMO7

831

Q8WWI1
KPVKVEAPEYIPISD

KNOP1

246

Q1ED39
ISSKVPKAEYIPTII

NSMF

351

Q6X4W1
VPKYVPLADVKSEKT

TMPO

391

P42167
DPLDIVITGKYKKPS

KIR3DX1

211

Q9H7L2
KEIKYEVDVLVPPAI

HMCN1

1721

Q96RW7
TTPKKKGVAVDYLPE

P4HA1

271

P13674
SVLSKSVPGYKPKVI

PHF10

361

Q8WUB8
VESLKLVTPYIPKAE

PATL2

241

C9JE40
APEVVTRKAYGPKVD

PAK2

411

Q13177
PIIVGEEYSKKPLIL

OTUD6B

251

Q8N6M0
IVEPKPTLKYVSFVD

P2RX7

391

Q99572
IYPETLKLEGKVPEL

ERVK-19

156

Q9YNA8
IPYLVVKVGEPKDVI

CKAP5

1291

Q14008
KPVILTYAPGTVKGI

IGSF10

2431

Q6WRI0
LEPTTPQEYILKGVV

TTC26

311

A0AVF1
IPVAGSKPVKVIYIN

ICE2

311

Q659A1
IIYPPEAQTIIVTKG

BOC

231

Q9BWV1
EYSEPLKGTEKTLPV

COL12A1

1461

Q99715
KPLLPDTEYKVTVTP

COL14A1

796

Q05707
YGVEPPVLVKLEKEI

GAS2L3

171

Q86XJ1
KGPPKALAYKTVEVV

BFSP1

611

Q12934
AIVKLSPEPIDVEYK

FAT3

396

Q8TDW7
ITKKVAVPYSPAAGV

CPE

431

P16870
KLLSVVPVPEGYSVK

C20orf27

91

Q9GZN8
IEELGKREVTIPPKY

CAST

191

P20810
SVKYEPPLGDIKVSK

IL12RB1

136

P42701
GLYPAPLKIIDVVKT

HADHA

296

P40939
GKSILYVVEEPECPK

ITGB3

701

P05106
YIKEGKIVPVEITIS

CMPK1

56

P30085
PILETVVEIKLFKGP

DLG2

186

Q15700
SQKVDTLPYVPEPIK

AHCTF1

1651

Q8WYP5
TLPYVPEPIKVAIAE

AHCTF1

1656

Q8WYP5
PGKVVIYSEPDVSEK

CRYBG1

1021

Q9Y4K1
RYAKAIGISEPVKVP

GTF2IRD1

576

Q9UHL9
IGISEPVKVPYSKFL

GTF2IRD1

581

Q9UHL9
KALGKSTVVPVPYEK

GTF2I

126

P78347
PEQGSYLPVLKIVSK

C4orf54

1211

D6RIA3
LKEIPYTKIETQGDP

EPB41L4A

571

Q9HCS5
DKIKQYVEGSSIPVP

ENPP2

751

Q13822
AELDVQYPPKKVTTV

CD22

411

P20273
FEVKITPGKPYILTV

C4A

241

P0C0L4
SVILEPPVLKGRKYT

ICAM4

136

Q14773
PVTVVVLKATAPFKY

MNDA

211

P41218
GIPYKQLTVGVPKEI

NNT

51

Q13423
VPLDYSVPIEIPTIK

MRPS30

251

Q9NP92
PVLVKDTPEDKYGIK

RHNO1

196

Q9BSD3
GKEPDIPLYKTLQTV

DROSHA

1276

Q9NRR4
EATPYVKKGSPVSEI

SNTB1

196

Q13884
GVKLVPGEPETKVIY

SUSD5

326

O60279
FPEEPKVGIKTIKVY

POLR2E

76

P19388
VVRKVPPGYSIKVFD

SMAD6

426

O43541
SKIYVSPKDLIGVVP

TMEM132D

416

Q14C87
GKEPIYTLPAIISKK

ARHGAP42

371

A6NI28
VKPKDLGLPTEAYIS

PSMD7

126

P51665
VEYGTEEKIKIPVIS

SAMD9L

1536

Q8IVG5
EEKIKIPVISVYSGP

SAMD9L

1541

Q8IVG5
IEYGINEKITIPITP

SAMD9

1541

Q5K651
SPPVKYVIKTVEVES

KIFC3

251

Q9BVG8
GIVPEVLKKIVTTYD

PLCL2

991

Q9UPR0
KTNTYIKTPVRGEEP

MEX3C

261

Q5U5Q3
TKEEYVKLILPELGP

SCYL2

401

Q6P3W7
KLPTVPITLTVKYDV

OCSTAMP

336

Q9BR26
ELPKKEAPYTLVGSI

POLR3H

176

Q9Y535
VYLKLPITGTEIVKP

CYB5R4

311

Q7L1T6
ETKVIDTTTLPVYPK

OSBPL10

671

Q9BXB5
PLPIEGRKEGVYIKV

SGCA

186

Q16586
IGPGSDYIIKEKTVL

SHANK1

651

Q9Y566
YTKVPEPGSIKVPDQ

SPRR3

106

Q9UBC9
SSEIKYKTPQPIGEV

CLGN

46

O14967
SVGYCIPKPEVILKL

ZNF37A

46

P17032
YTKEPKEQIISVGPI

TECTA

2066

O75443
PKVTPTKESYTEEIV

DNTTIP2

126

Q5QJE6
YPPGLSELKVAEVKE

PRR22

246

Q8IZ63
PTKKYADVIIPRGVD

UCK1

201

Q9HA47
KTNTYIKTPVRGEEP

MEX3A

161

A1L020
GISTKPVYIPEVELN

TRIM25

316

Q14258
KDKSYEPEVIPVQKP

ZNF292

661

O60281
KVVEKAYPEEPVGVV

UAP1L1

281

Q3KQV9
VKTPIVPVEDLPYTL

VWA5A

166

O00534
YSPKLERKTSEGIIP

PREX2

1056

Q70Z35
TPPYCKAITEPVTVK

REL

246

Q04864
GSQIIPKVTEIIPKY

PKHD1L1

26

Q86WI1
PKVTEIIPKYGSING

PKHD1L1

31

Q86WI1
PGKASYKDVLLVVVP

SLAMF8

226

Q9P0V8
PKVVSKYIESPVLFL

TTLL12

446

Q14166
IKTEPVDYEFKPIVV

ZEB1

346

P37275
YEPLEDPGVKSVTKI

TALDO1

206

P37837
PGEVPLKDIYPKDVT

VWA8

1431

A3KMH1
TVEEIIYPTPKVVAG

SLC36A4

471

Q6YBV0
KVTALTKKPDVYIPE

SIGLEC11

151

Q96RL6
TKKPDVYIPETLEPG

SIGLEC11

156

Q96RL6
VVGNVSKYIPPDKRE

YEATS2

211

Q9ULM3
IYGKLLKTTVTPEGE

KCNJ1

226

P48048
EVYHKVVPQIPVKSG

AMDHD2

116

Q9Y303
QEIVEKVIKVYGPST

N4BP1

361

O75113
ILFVITKPDVYKSPA

NACA4P

101

Q9BZK3
GKKVVLVPYTSEHVP

NAT9

11

Q9BTE0