Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nitrate reductase activity	MTARC2 MTARC1	1.30e-04	3	132	2	GO:0008940
GeneOntologyMolecularFunction	ATP:phosphate antiporter activity	SLC25A25 SLC25A23	1.30e-04	3	132	2	GO:0140987
Domain	CH	SPTBN2 GAS2L2 ASPM NAV2 MACF1	9.61e-05	65	132	5	SM00033
Domain	CH	SPTBN2 GAS2L2 ASPM NAV2 MACF1	1.37e-04	70	132	5	PF00307
Domain	-	SPTBN2 GAS2L2 ASPM NAV2 MACF1	1.46e-04	71	132	5	1.10.418.10
Domain	ABC_tran_Xtn	ABCF3 ABCF2	1.48e-04	3	132	2	PF12848
Domain	ABC_tran_Xtn	ABCF3 ABCF2	1.48e-04	3	132	2	IPR032781
Domain	MOSC	MTARC2 MTARC1	1.48e-04	3	132	2	PF03473
Domain	MOSC_N	MTARC2 MTARC1	1.48e-04	3	132	2	PF03476
Domain	MOSC	MTARC2 MTARC1	1.48e-04	3	132	2	PS51340
Domain	MOSC_N	MTARC2 MTARC1	1.48e-04	3	132	2	IPR005303
Domain	MoCF_Sase_C	MTARC2 MTARC1	1.48e-04	3	132	2	IPR005302
Domain	PH	SH2B3 SPTBN2 IRS1 PLEKHH3 FARP2 FGD1 ARAP1 TECPR1 FERMT3	1.62e-04	278	132	9	SM00233
Domain	PH_DOMAIN	SH2B3 SPTBN2 IRS1 PLEKHH3 FARP2 FGD1 ARAP1 TECPR1 FERMT3	1.67e-04	279	132	9	PS50003
Domain	CH	SPTBN2 GAS2L2 ASPM NAV2 MACF1	1.67e-04	73	132	5	PS50021
Domain	PH_domain	SH2B3 SPTBN2 IRS1 PLEKHH3 FARP2 FGD1 ARAP1 TECPR1 FERMT3	1.71e-04	280	132	9	IPR001849
Domain	CH-domain	SPTBN2 GAS2L2 ASPM NAV2 MACF1	1.90e-04	75	132	5	IPR001715
Domain	Pyrv_Knase-like_insert_dom	MTARC2 MTARC1	4.89e-04	5	132	2	IPR011037
Domain	Spectrin	SPTAN1 SPTBN2 MACF1	5.51e-04	23	132	3	PF00435
Domain	RIH_assoc-dom	RYR2 ITPR2	7.30e-04	6	132	2	IPR013662
Domain	GAR	GAS2L2 MACF1	7.30e-04	6	132	2	PS51460
Domain	Ins145_P3_rec	RYR2 ITPR2	7.30e-04	6	132	2	PF08709
Domain	GAS2	GAS2L2 MACF1	7.30e-04	6	132	2	PF02187
Domain	RIH_assoc	RYR2 ITPR2	7.30e-04	6	132	2	PF08454
Domain	RIH_dom	RYR2 ITPR2	7.30e-04	6	132	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 ITPR2	7.30e-04	6	132	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 ITPR2	7.30e-04	6	132	2	IPR015925
Domain	-	RYR2 ITPR2	7.30e-04	6	132	2	1.25.10.30
Domain	-	GAS2L2 MACF1	7.30e-04	6	132	2	3.30.920.20
Domain	RYDR_ITPR	RYR2 ITPR2	7.30e-04	6	132	2	PF01365
Domain	GAS_dom	GAS2L2 MACF1	7.30e-04	6	132	2	IPR003108
Domain	GAS2	GAS2L2 MACF1	7.30e-04	6	132	2	SM00243
Domain	Spectrin_repeat	SPTAN1 SPTBN2 MACF1	1.10e-03	29	132	3	IPR002017
Domain	PH	SH2B3 SPTBN2 IRS1 FARP2 FGD1 ARAP1 FERMT3	1.23e-03	229	132	7	PF00169
Domain	SPEC	SPTAN1 SPTBN2 MACF1	1.47e-03	32	132	3	SM00150
Domain	Spectrin/alpha-actinin	SPTAN1 SPTBN2 MACF1	1.47e-03	32	132	3	IPR018159
Domain	Mit_carrier	SLC25A25 SLC25A43 SLC25A23	1.47e-03	32	132	3	IPR002067
Domain	-	SH2B3 SPTBN2 IRS1 PLEKHH3 FARP2 FGD1 ARAP1 TECPR1 FERMT3	1.86e-03	391	132	9	2.30.29.30
Domain	MIR	RYR2 ITPR2	2.15e-03	10	132	2	PF02815
Domain	MIR_motif	RYR2 ITPR2	2.15e-03	10	132	2	IPR016093
Domain	MIR	RYR2 ITPR2	2.15e-03	10	132	2	PS50919
Domain	MIR	RYR2 ITPR2	2.15e-03	10	132	2	SM00472
Domain	-	CAPN14 SPTAN1 SLC25A25 STAT2 RYR2 MACF1 SLC25A23	2.57e-03	261	132	7	1.10.238.10
Domain	PNMA	PNMA1 PNMA6A	2.62e-03	11	132	2	IPR026523
Domain	PNMA	PNMA1 PNMA6A	2.62e-03	11	132	2	PF14893
Domain	EF-hand_7	SPTAN1 SLC25A25 MACF1 SLC25A23	3.10e-03	85	132	4	PF13499
Domain	PH_dom-like	SH2B3 SPTBN2 IRS1 PLEKHH3 FARP2 FGD1 ARAP1 TECPR1 FERMT3	3.30e-03	426	132	9	IPR011993
Domain	FERM_M	PLEKHH3 FARP2 FERMT3	4.20e-03	46	132	3	PF00373
Domain	PP2C_SIG	PPM1H PPM1L	4.27e-03	14	132	2	SM00331
Domain	EF-hand-dom_pair	CAPN14 SPTAN1 SLC25A25 STAT2 RYR2 MACF1 SLC25A23	4.34e-03	287	132	7	IPR011992
Domain	Galactose-bd-like	PCSK5 MYCBP2 LAMA1 NGLY1	4.45e-03	94	132	4	IPR008979
Domain	PPM_1	PPM1H PPM1L	4.90e-03	15	132	2	PS01032
Domain	FERM_central	PLEKHH3 FARP2 FERMT3	5.02e-03	49	132	3	IPR019748
Domain	FERM_1	PLEKHH3 FARP2 FERMT3	5.31e-03	50	132	3	PS00660
Domain	FERM_2	PLEKHH3 FARP2 FERMT3	5.31e-03	50	132	3	PS00661
Domain	FERM_3	PLEKHH3 FARP2 FERMT3	5.31e-03	50	132	3	PS50057
Domain	Band_41_domain	PLEKHH3 FARP2 FERMT3	5.31e-03	50	132	3	IPR019749
Domain	B41	PLEKHH3 FARP2 FERMT3	5.31e-03	50	132	3	SM00295
Domain	EFh	SPTAN1 SLC25A25 RYR2 MACF1 SLC25A23	5.32e-03	158	132	5	SM00054
Domain	Ald_DH_CS_GLU	ALDH1A2 ALDH1L2	5.58e-03	16	132	2	IPR029510
Domain	EF_HAND_2	CAPN14 SPTAN1 SLC25A25 RYR2 MACF1 SLC25A23	6.03e-03	231	132	6	PS50222
Domain	EF_hand_dom	CAPN14 SPTAN1 SLC25A25 RYR2 MACF1 SLC25A23	6.16e-03	232	132	6	IPR002048
Domain	-	SLC25A25 SLC25A43 SLC25A23	6.25e-03	53	132	3	1.50.40.10
Domain	Mito_carr	SLC25A25 SLC25A43 SLC25A23	6.25e-03	53	132	3	PF00153
Domain	Quinoprotein_ADH-like_supfam	EMC1 GEMIN5 MTARC2	6.25e-03	53	132	3	IPR011047
Domain	SOLCAR	SLC25A25 SLC25A43 SLC25A23	6.25e-03	53	132	3	PS50920
Domain	Mitochondrial_sb/sol_carrier	SLC25A25 SLC25A43 SLC25A23	6.25e-03	53	132	3	IPR018108
Domain	Mt_carrier_dom	SLC25A25 SLC25A43 SLC25A23	6.25e-03	53	132	3	IPR023395
Domain	PP2C	PPM1H PPM1L	6.29e-03	17	132	2	IPR015655
Domain	Ald_DH_CS_CYS	ALDH1A2 ALDH1L2	6.29e-03	17	132	2	IPR016160
Domain	ALDEHYDE_DEHYDR_CYS	ALDH1A2 ALDH1L2	7.04e-03	18	132	2	PS00070
Domain	ALDEHYDE_DEHYDR_GLU	ALDH1A2 ALDH1L2	7.04e-03	18	132	2	PS00687
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	UNC13B PCSK5 SH2B3 MYCBP2 CHSY1 GEMIN5 AMBRA1 TMCO6 IRS1 FRYL ITGA3 WNK1 REXO1 MADD PLEKHH3 ITPR2 NCOR2 TNRC18 MROH6 ARHGAP44 EHMT1 NAV2 TBCD ARAP1	1.04e-11	1105	137	24	35748872
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	THSD7A MYCBP2 WNK1 EHMT1 NAV2 MACF1 SCRIB DAGLA KDM4B ARAP1	2.36e-08	225	137	10	12168954
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	SPTAN1 FRYL RYR2 MADD TENM3 ASPM DAGLA	1.61e-06	142	137	7	11812828
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	FYTTD1 ATG7 MYCBP2 FRYL IQCN PPM1H FARP2 KIAA1671 NCOR2 TNRC18 SH3PXD2A ARHGAP44 EHMT1 ANTXR1 MACF1 DAGLA MTARC1 KDM4B TBCD ARAP1	1.65e-06	1489	137	20	28611215
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	EMC1 MYCBP2 SPTAN1 IRS1 FRYL WNK1 PPM1H MADD KIAA1671 SH3PXD2A NAV2 TJP2 MACF1 NR3C2 SCRIB	1.68e-06	861	137	15	36931259
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	HSCB MPV17L2 FPGS MRPL58 ABCF2 SLC25A25 COQ10A CRLS1 GLDC ALDH1L2 NFXL1 MTARC2 MCAT SLC25A23 MTARC1	4.07e-06	926	137	15	20877624
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	RPGRIP1 ATG7 ACHE ASIC3 RP1L1 FSCN2 MACF1 ARAP1	4.28e-06	233	137	8	32290105
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	HSCB NDUFAF8 MPV17L2 FPGS MRPL58 SLC25A25 COQ10A CRLS1 GLDC ALDH1L2 RPUSD3 FLAD1 MTARC2 MCAT SLC25A23 MTARC1	1.10e-05	1136	137	16	34800366
Pubmed	A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13.	UNC13B SPTBN2	1.54e-05	2	137	2	9704016
Pubmed	The Chlamydomonas reinhardtii molybdenum cofactor enzyme crARC has a Zn-dependent activity and protein partners similar to those of its human homologue.	MTARC2 MTARC1	1.54e-05	2	137	2	21803866
Pubmed	MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases.	MTARC2 MTARC1	1.54e-05	2	137	2	11886751
Pubmed	Functional characterization of protein variants encoded by nonsynonymous single nucleotide polymorphisms in MARC1 and MARC2 in healthy Caucasians.	MTARC2 MTARC1	1.54e-05	2	137	2	24423752
Pubmed	Mitochondrial calcium overload is a key determinant in heart failure.	RYR2 ITPR2	1.54e-05	2	137	2	26217001
Pubmed	The mitochondrial amidoxime-reducing component (mARC1) is a novel signal-anchored protein of the outer mitochondrial membrane.	MTARC2 MTARC1	1.54e-05	2	137	2	23086957
Pubmed	AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through an ATG7-independent pathway.	ATG7 AMBRA1	1.54e-05	2	137	2	28789945
Pubmed	The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine.	MTARC2 MTARC1	1.54e-05	2	137	2	25713076
Pubmed	Functional local crosstalk of inositol 1,4,5-trisphosphate receptor- and ryanodine receptor-dependent Ca2+ release in atrial cardiomyocytes.	RYR2 ITPR2	1.54e-05	2	137	2	28158491
Pubmed	Interaction of acetylcholinesterase with the G4 domain of the laminin alpha1-chain.	ACHE LAMA1	1.54e-05	2	137	2	18215127
Pubmed	Characterization of a new beta-spectrin gene which is predominantly expressed in brain.	SPTAN1 SPTBN2	1.54e-05	2	137	2	9675416
Pubmed	Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor-dependent apoptosis.	ATG7 AMBRA1	1.54e-05	2	137	2	27390127
Pubmed	Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC).	MTARC2 MTARC1	1.54e-05	2	137	2	21029045
Pubmed	sh- Ambra1 inhibits IRS-1/PI3K/Akt signalling pathway to reduce autophagy in gestational diabetes.	AMBRA1 IRS1	1.54e-05	2	137	2	38497391
Pubmed	Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse.	MTARC2 MTARC1	1.54e-05	2	137	2	38437227
Pubmed	Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase.	IRS1 PIK3R2	1.54e-05	2	137	2	11120660
Pubmed	Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase.	IRS1 ALK	1.54e-05	2	137	2	16878150
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	EMC1 MYCBP2 SPTAN1 SPTBN2 EYA1 C2CD4C PPM1H MADD ITPR2 KIAA1671 NCOR2 KIF15 PPM1L SCRIB UTP3	1.78e-05	1049	137	15	27880917
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	LRP12 EMC1 MYCBP2 LAMA1 RNF149 CHSY1 ITGA3 MADD ITPR2 TENM3 PPM1L ANTXR1 ST6GALNAC4 NGLY1 SCRIB MTARC1	2.18e-05	1201	137	16	35696571
Pubmed	Laminin alpha5 chain is required for intestinal smooth muscle development.	VIL1 LAMA1 ITGA3	2.63e-05	15	137	3	12921739
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	EMC1 MYCBP2 FPGS AMBRA1 ABCF2 SLC25A25 KIAA1671 MTARC2 UTP3 MTARC1 TBCD	3.00e-05	606	137	11	36538041
Pubmed	Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton.	SPTAN1 TJP2	4.61e-05	3	137	2	10874042
Pubmed	Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains.	SLC25A25 SLC25A23	4.61e-05	3	137	2	15054102
Pubmed	Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways.	MADD PIK3R2	4.61e-05	3	137	2	26517243
Pubmed	Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site.	ACHE LAMA1	4.61e-05	3	137	2	12524166
Pubmed	Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.	IRS1 PIK3R2	4.61e-05	3	137	2	12730242
Pubmed	Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis.	CSF3R CTSG	4.61e-05	3	137	2	12384420
Pubmed	Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution.	SLC25A25 SLC25A23	4.61e-05	3	137	2	15123600
Pubmed	Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3.	SLC25A25 SLC25A23	4.61e-05	3	137	2	23344948
Pubmed	Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia.	SH3PXD2A FGD1	4.61e-05	3	137	2	32673397
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTAN1 SPTBN2 ITGA3	4.67e-05	18	137	3	12119179
Pubmed	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	ACHE IRS1 ITGA3 STAT2 NCOR2	4.68e-05	99	137	5	19730683
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	WNK1 KIAA1671 NCOR2 TNRC18 PIK3R2 AP5B1 ARAP1 TECPR1 DNMT3B	5.52e-05	430	137	9	35044719
Pubmed	CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity.	VIL1 SPTAN1 SCRIB	6.49e-05	20	137	3	19726564
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	HSCB NDUFAF8 MPV17L2 FPGS MRPL58 ABCF2 SLC25A25 CRLS1 SLC25A43 GLDC ALDH1L2 MTARC2 MCAT SLC25A23	7.05e-05	1047	137	14	18614015
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	MYCBP2 IRS1 FRYL WNK1 FARP2 PIK3R2 TJP2	7.18e-05	255	137	7	15324660
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	ABCF3 SPTAN1 SPTBN2 STAT2 KIAA1671 TENM3 NAV2 TJP2 MACF1 SCRIB	8.59e-05	565	137	10	25468996
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	HSCB EMC1 FPGS ABCF2 WNK1 FARP2 GLDC ALDH1L2 FLAD1 NFXL1 MTARC1	9.10e-05	686	137	11	28380382
Pubmed	Biochemical and spectroscopic characterization of the human mitochondrial amidoxime reducing components hmARC-1 and hmARC-2 suggests the existence of a new molybdenum enzyme family in eukaryotes.	MTARC2 MTARC1	9.19e-05	4	137	2	20861021
Pubmed	Genetic variants in epigenetic genes and breast cancer risk.	EHMT1 DNMT3B	9.19e-05	4	137	2	16501248
Pubmed	Association of self-DNA mediated TLR9-related gene, DNA methyltransferase, and cytokeratin protein expression alterations in HT29-cells to DNA fragment length and methylation status.	TLR9 DNMT3B	9.19e-05	4	137	2	24459426
Pubmed	hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells.	TJP2 SCRIB	9.19e-05	4	137	2	15975580
Pubmed	Impact of viral and host DNA methylations on HPV16-related cervical cancer pathogenesis.	TLR9 DNMT3B	9.19e-05	4	137	2	28459195
Pubmed	Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.	IRS1 PIK3R2	9.19e-05	4	137	2	7559478
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR2 ITPR2	9.19e-05	4	137	2	19120137
Pubmed	Non-enzymatic developmental functions of acetylcholinesterase--the question of redundancy.	ACHE LAMA1	9.19e-05	4	137	2	18785927
Pubmed	Nitrite reductase and nitric-oxide synthase activity of the mitochondrial molybdopterin enzymes mARC1 and mARC2.	MTARC2 MTARC1	9.19e-05	4	137	2	24500710
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	MYCBP2 CHSY1 SLC25A25 WNK1 RYR2 PLEKHH3 ASPM MTARC2 KLHDC10	9.53e-05	462	137	9	31138677
Pubmed	The role of PI3K in immune cells.	IRS1 TLR9 PIK3R2	1.14e-04	24	137	3	12660731
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	UNC13B SH2B3 PPM1H FARP2 TENM3 TJP2 DAGLA KDM4B	1.18e-04	371	137	8	15747579
Pubmed	NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.	SPTAN1 SPTBN2 KIAA1671	1.29e-04	25	137	3	30309841
Pubmed	Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.	ATG7 CHSY1 TNRC18	1.29e-04	25	137	3	24068947
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ABCF3 MYCBP2 SPTAN1 GEMIN5 ABCF2 SH3PXD2A EHMT1 NFXL1 TJP2 MACF1 NOL8	1.46e-04	724	137	11	36232890
Pubmed	The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells.	MTARC2 MTARC1	1.53e-04	5	137	2	23703616
Pubmed	ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK).	IRS1 ALK	1.53e-04	5	137	2	9174053
Pubmed	Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance.	CSF3R CTSG	1.53e-04	5	137	2	21940780
Pubmed	Localization of the murine homolog of the anaplastic lymphoma kinase (AlK) gene on mouse chromosome 17.	LAMA1 ALK	1.53e-04	5	137	2	7736780
Pubmed	Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.	IRS1 PIK3R2	1.53e-04	5	137	2	7541045
Pubmed	Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5).	IRS1 ALK	1.53e-04	5	137	2	8633037
Pubmed	Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations.	IRS1 PIK3R2	1.53e-04	5	137	2	11172806
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	THSD7A SPTBN2 RNF8 WNK1 REXO1 FARP2 TNRC18 MACF1 KLHDC10	1.55e-04	493	137	9	15368895
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	VIL1 RPGRIP1 SPTAN1 SPTBN2 ABCF2 RYR2 TNRC18 SH3PXD2A ASPM NFXL1 NAV2 ANTXR1 MACF1 NGLY1 POLQ DNMT3B	1.85e-04	1442	137	16	35575683
Pubmed	Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.	UNC13B EMC1 MYCBP2 ABCF2 KLHDC10 TBCD	1.87e-04	209	137	6	26389662
Pubmed	Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation.	FPGS PPM1L	2.29e-04	6	137	2	24583629
Pubmed	The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease.	PNMA1 PNMA6A	2.29e-04	6	137	2	16214224
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR2 ITPR2	2.29e-04	6	137	2	23463619
Pubmed	Epigenetic response to environmental stress: Assembly of BRG1-G9a/GLP-DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts.	EHMT1 DNMT3B	2.29e-04	6	137	2	26952936
Pubmed	A widely expressed betaIII spectrin associated with Golgi and cytoplasmic vesicles.	PCSK5 SPTBN2	2.29e-04	6	137	2	9826670
Pubmed	Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection.	ATG7 CTSG	2.29e-04	6	137	2	27551156
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR2 ITPR2	2.29e-04	6	137	2	25966694
Pubmed	Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis.	NCOR2 ALDH1A2	2.29e-04	6	137	2	27506116
Pubmed	ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors.	SPTAN1 SPTBN2	2.29e-04	6	137	2	37069398
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR2 ITPR2	2.29e-04	6	137	2	20519450
Pubmed	In vivo assembly of the axon initial segment in motor neurons.	SPTAN1 SPTBN2	2.29e-04	6	137	2	23728480
Pubmed	Insights into the release mechanism of astrocytic glutamate evoking in neurons NMDA receptor-mediated slow depolarizing inward currents.	KCNK4 ITPR2	2.29e-04	6	137	2	30144319
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR2 ITPR2	2.29e-04	6	137	2	16844763
Pubmed	The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase.	IRS1 PIK3R2	2.29e-04	6	137	2	7542745
Pubmed	Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton.	SPTAN1 SPTBN2	2.29e-04	6	137	2	16687515
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	FYTTD1 FARP2 KIAA1671 SH3PXD2A PIK3R2 ARHGAP44 FGD1 TJP2 MCAT SCRIB CTSG ARAP1	2.85e-04	916	137	12	32203420
Pubmed	Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes.	ATG7 TLR9	3.19e-04	7	137	2	23219390
Pubmed	Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer.	EHMT1 DNMT3B	3.19e-04	7	137	2	20960050
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR2 ITPR2	3.19e-04	7	137	2	11860456
Pubmed	Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer.	EHMT1 DNMT3B	3.19e-04	7	137	2	19843671
Pubmed	Differential expression of laminin chain-specific mRNA transcripts during mouse preimplantation embryo development.	LAMA1 ITGA3	3.19e-04	7	137	2	8722691
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	UNC13B THSD7A NLRP9 ASPM EHMT1 NFXL1 NAV2	3.24e-04	326	137	7	17015433
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	FRYL TMC3 SLC5A2 FARP2 ANKRD13A CRLS1 SLC25A43 GAS2L2 GLDC SH3PXD2A PIK3R2 ASPM CFAP61 KDM4B	4.07e-04	1242	137	14	30973865
Pubmed	The N-reductive system composed of mitochondrial amidoxime reducing component (mARC), cytochrome b5 (CYB5B) and cytochrome b5 reductase (CYB5R) is regulated by fasting and high fat diet in mice.	MTARC2 MTARC1	4.25e-04	8	137	2	25144769
Pubmed	Differential expression of integrin alpha subunits supports distinct roles during lung branching morphogenesis.	LAMA1 ITGA3	4.25e-04	8	137	2	8725284
Pubmed	Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.	IRS1 PIK3R2	4.25e-04	8	137	2	12167717
Pubmed	Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells.	ATG7 AMBRA1	4.25e-04	8	137	2	22240590
Pubmed	Genome-wide association study of the child behavior checklist dysregulation profile.	ALK FERMT3	4.25e-04	8	137	2	21784300
Pubmed	TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways.	TLR9 STAT2	4.25e-04	8	137	2	24598055
Interaction	TOP3B interactions	UNC13B PCSK5 SH2B3 MYCBP2 SPTAN1 SPTBN2 CHSY1 GEMIN5 AMBRA1 TMCO6 IRS1 FRYL ITGA3 WNK1 REXO1 MADD PLEKHH3 ITPR2 NCOR2 TNRC18 MROH6 ARHGAP44 EHMT1 NAV2 TBCD ARAP1	4.35e-06	1470	135	26	int:TOP3B
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SH2B3 SPTBN2 IRS1 PLEKHH3 FARP2 FGD1 ARAP1 FERMT3	1.29e-05	206	95	8	682
GeneFamily	ATP binding cassette subfamily F	ABCF3 ABCF2	8.17e-05	3	95	2	810
GeneFamily	EF-hand domain containing\|Spectrins	SPTAN1 SPTBN2	5.64e-04	7	95	2	1113
GeneFamily	EF-hand domain containing	CAPN14 SPTAN1 SLC25A25 RYR2 MACF1 SLC25A23	1.05e-03	219	95	6	863
GeneFamily	Paraneoplastic Ma antigens	PNMA1 PNMA6A	1.46e-03	11	95	2	671
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PLEKHH3 FARP2 FERMT3	2.30e-03	50	95	3	1293
GeneFamily	Protein phosphatases, Mg2+/Mn2+ dependent	PPM1H PPM1L	3.53e-03	17	95	2	701
ToppCell	LV-14._Fibroblast_III\|LV / Chamber and Cluster_Paper	PCSK5 LINC00473 CHSY1 NCOR2 SH3PXD2A NAV2 ANTXR1	2.38e-06	194	137	7	927c26aea0147f7a4b8fb3f192de4de263f1b978
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SH2B3 RNF149 FCGRT AP5B1 SIGLEC10 ARAP1 FERMT3	2.91e-06	200	137	7	74ceebee9af63f8b3ec5857eff1b662752bc3862
ToppCell	21-Trachea-Immune-Immune\|Trachea / Age, Tissue, Lineage and Cell class	GPBAR1 SPTBN2 AMBRA1 TRPM8 MYEOV DAGLA	3.72e-06	134	137	6	4f0465324cc5b443ebadb68aef63be79b74f6ff9
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_B-GC_B_(II)\|lymph-node_spleen / Manually curated celltypes from each tissue	IRS1 SLC25A25 GSTA4 SIGLEC10 ST6GALNAC4 NGLY1	7.69e-06	152	137	6	4f690aed23338687bdefc47e8a2f3d1fdb2b6447
ToppCell	droplet-Liver-Hepatocytes-21m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FPGS UROC1 SLC25A25 CRLS1 GLDC SLC25A23	1.19e-05	164	137	6	90afae3cca108ebfb44ff2ec4adcbb8c68a0bdf2
ToppCell	facs-Lung-nan-3m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN2 EYA1 SLC5A2 GSTA4 FARP2 ALDH1A2	1.83e-05	177	137	6	e5070934c674a46e070b0d52b9a374516bf6aea1
ToppCell	facs-Lung-nan-3m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN2 EYA1 SLC5A2 GSTA4 FARP2 ALDH1A2	1.83e-05	177	137	6	b37d821f4f3204daf7c568ac17a0af0ba97273d6
ToppCell	RV-11._Adipocyte\|RV / Chamber and Cluster_Paper	PCSK5 MYCBP2 ITPR2 CRLS1 TENM3 MTARC1	1.89e-05	178	137	6	278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UNC13B THSD7A ITGA3 GSTA4 ARHGAP44 NAV2	1.95e-05	179	137	6	cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCell	facs-Marrow-T-cells-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHH3 FARP2 SLC25A43 ALDH1L2 NFXL1 NGLY1	2.07e-05	181	137	6	57f0cc749ae8b6a3d77e2af31f9a6e4739c57049
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-1\|bone_marrow / Manually curated celltypes from each tissue	ASPHD1 TNFSF13 KIF15 CSF3R ASPM POLQ	2.07e-05	181	137	6	ccd0ed30cea3fb41d34f28b3e8d80a94493bef3c
ToppCell	facs-Marrow-T-cells-3m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHH3 FARP2 SLC25A43 ALDH1L2 NFXL1 NGLY1	2.07e-05	181	137	6	d01b35cc2fc57991a35be6a06cb7351fbabd9a11
ToppCell	facs-Marrow-T-cells-3m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHH3 FARP2 SLC25A43 ALDH1L2 NFXL1 NGLY1	2.20e-05	183	137	6	b0b835f3b1de1bd46a47e1b805aa8994cd3a4e3e
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	PCSK5 PPM1H ITPR2 TNRC18 GLDC SH3PXD2A	2.42e-05	186	137	6	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD7A SPTBN2 IRS1 ITPR2 PPM1L NR3C2	2.42e-05	186	137	6	a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	PCSK5 PPM1H ITPR2 TNRC18 GLDC SH3PXD2A	2.42e-05	186	137	6	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	UNC13B LAMA1 PPM1H GLDC ARHGAP44 NR3C2	2.49e-05	187	137	6	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Lymphocytic\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSCB RPGRIP1 ASPM CTSG FERMT3 DNMT3B	2.49e-05	187	137	6	e53471c3e146a6f54788d81ecc469aba55b051bb
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Lymphocytic-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSCB RPGRIP1 ASPM CTSG FERMT3 DNMT3B	2.49e-05	187	137	6	3d7d51fbadb20dc884d0b3c0d61b80f022b19d09
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN14 EYA1 ITGA3 PPM1H ARHGAP44 NR3C2	2.49e-05	187	137	6	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	KIF15 GLDC ALDH1L2 ASPM ST6GALNAC4 POLQ	2.57e-05	188	137	6	ecba5d06cbf3254448255a2aeefffe711f43310e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD7A SPTBN2 IRS1 ITPR2 PPM1L NR3C2	2.57e-05	188	137	6	e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	KIF15 GLDC ALDH1L2 ASPM ST6GALNAC4 POLQ	2.57e-05	188	137	6	8cf135da4d1d2500755d2809d60b41509af9fa8b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LINC00473 LAMA1 EYA1 WNK1 NAV2 NR3C2	2.64e-05	189	137	6	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LINC00473 LAMA1 EYA1 WNK1 NAV2 NR3C2	2.64e-05	189	137	6	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	THSD7A CHSY1 PPM1H ITPR2 KIAA1671 TIE1	2.64e-05	189	137	6	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN14 EYA1 ITGA3 PPM1H ARHGAP44 NR3C2	2.64e-05	189	137	6	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYCBP2 SPTAN1 SH3PXD2A TJP2 ANTXR1 MACF1	2.72e-05	190	137	6	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK5 THSD7A TENM3 GLDC ASPM ALK	2.80e-05	191	137	6	782bc7946417549ffd39e5b596db659436fa01ba
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LINC00473 THSD7A SPTBN2 ANKRD13A PPM1L NR3C2	2.89e-05	192	137	6	f7e7491426bbd6ed29a465b58bf67acb93dbb90a
ToppCell	mild_COVID-19_(asymptomatic)-Non-classical_Monocyte\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	GPBAR1 SH2B3 FCGRT ANKDD1A SIGLEC10 ARAP1	2.97e-05	193	137	6	7839040e703877ef321494ad8926a8604729ceda
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	THSD7A CHSY1 PPM1H KIAA1671 ALDH1A2 TIE1	2.97e-05	193	137	6	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	severe-Myeloid-CD16_Monocytes\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	GPBAR1 SH2B3 SLC25A25 GSTA4 PPM1L SIGLEC10	3.06e-05	194	137	6	1b33248b8a7cb914783bcf9e6a80481b4db7e0e8
ToppCell	severe_COVID-19-Non-classical_Monocyte\|severe_COVID-19 / disease group, cell group and cell class (v2)	GPBAR1 SH2B3 GSTA4 FCGRT SIGLEC10 ARAP1	3.24e-05	196	137	6	34c1c74cad5e23196e86cfd6f19c836fe57b2264
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SH2B3 CHSY1 ITPR2 LMAN1L FCGRT FERMT3	3.33e-05	197	137	6	b597c292fc1cb381a4325fed15a32966c38def28
ToppCell	control-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GPBAR1 SH2B3 STAT2 FCGRT KLHDC8B ARAP1	3.43e-05	198	137	6	35499a5231818e3432cf69b5c4a58c02f7771db8
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	MYCBP2 LAMA1 RYR2 ALDH1A2 TENM3 MACF1	3.53e-05	199	137	6	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	Transverse-B_cell-B_cell_cycling\|B_cell / Region, Cell class and subclass	AMBRA1 KIF15 TIE1 AP5B1 ASPM POLQ	3.53e-05	199	137	6	170ae68963d31f3b821b6f0e8f0c039bea0bc981
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SH2B3 RNF149 IQCN FCGRT AP5B1 FERMT3	3.63e-05	200	137	6	88d713dfc792e7609bf7ecfb28f87cb748088570
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LINC00473 THSD7A SPTBN2 NR3C2 ROBO3	9.19e-05	147	137	5	64fa0753a3a79f492ef8acc6942bf90d379a983f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WNK1 RP1L1 SIGLEC10 TRPM8 NR3C2	1.11e-04	153	137	5	9b6675ace8a83c8d446b722301d0ec4e6840f3fc
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LMAN1L KIF15 ASPM POLQ TBCD	1.21e-04	156	137	5	b3f10cd044f24807576e7d56e51df7064dbf6c50
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WNK1 RP1L1 SIGLEC10 TRPM8 NR3C2	1.25e-04	157	137	5	2c5295043611bac7dfa4aef2146681bce4a33a8f
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPTBN2 PLEKHH3 KCNQ4 ARHGAP44 SLC25A23	1.29e-04	158	137	5	17a13c5719eb363f2eb8f1d4e171429c6a1ce1e9
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-cortical_neurons_1\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	SPTBN2 ITGA3 ASIC3 MADD DAGLA	1.29e-04	158	137	5	1f94622186d8329357fa06785e03eeacf29ab1ce
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SPTBN2 PLEKHH3 KCNQ4 ARHGAP44 SLC25A23	1.29e-04	158	137	5	1397078f909338fa5fa3b01748db891e5e3fc9e7
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPTBN2 PLEKHH3 KCNQ4 ARHGAP44 SLC25A23	1.29e-04	158	137	5	e5451cfe67e882eb0c1eca287740f8ab75370abc
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPV17L2 PLEKHH3 KIF15 ASPM BRINP2	1.41e-04	161	137	5	9f02b94e29e60d50e92eaa748ebf0c36d3671bb3
ToppCell	Mild_COVID-19-B_cell-Plasmablast\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	SPTBN2 PLEKHH3 KCNQ4 ARHGAP44 SLC25A23	1.45e-04	162	137	5	b67f6fb3d7f6093c8ef02398ff8fea4d0fb41a3b
ToppCell	facs-Marrow-B-cells-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNMA1 ACHE SLC25A43 ALDH1L2 BRINP2	1.58e-04	165	137	5	361a605d8f833d9ec54b120480dce397da35f9c3
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ITGA3 ANKRD60 NR3C2 NGLY1 TECPR1	1.62e-04	166	137	5	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ITGA3 ANKRD60 NR3C2 NGLY1 TECPR1	1.62e-04	166	137	5	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC25A25 PPM1H ITPR2 PNMA6A DNMT3B	1.67e-04	167	137	5	49d9220f22d10ff06c0512c9c40c26ad51728e4f
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC25A25 PPM1H ITPR2 PNMA6A DNMT3B	1.67e-04	167	137	5	7ec032a98a13504d15c7e3a4e259278d07f40180
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SMYD1 KIF15 ASPM NAV2 POLQ	1.67e-04	167	137	5	bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC25A25 PPM1H ITPR2 PNMA6A DNMT3B	1.67e-04	167	137	5	5e3588eee73693a996bb4846427cf0038ceafbca
ToppCell	healthy_donor-Myeloid-Monocytic-Developing_Neutrophil\|healthy_donor / Disease condition, Lineage, Cell class and subclass	KIF15 KCNQ4 ASPM POLQ CTSG	1.81e-04	170	137	5	cfd7f29805b7c51666b0eaf269c36c96b8765a1a
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX12 KIF15 PRSS50 CTSG FERMT3	1.81e-04	170	137	5	4ab2a890c8631028ee9099d2faf6091c742a317b
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	RNF149 PLEKHH3 ANKRD13A CSF3R CELF2-AS1	1.86e-04	171	137	5	2b7c5a557c4bc5c573211c4d618bdd6766a24916
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	THSD7A WNT2B C2CD4C TIE1 BRINP2	1.86e-04	171	137	5	1597459c971d6befa991d59dc66b41b6a522f797
ToppCell	normal_Lung-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	LRP12 TNRC18 TIE1 ROBO3 KLHDC10	1.86e-04	171	137	5	f49dfe11ae66d82125b577c48345a13683d7bb7b
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	RNF149 PLEKHH3 ANKRD13A CSF3R CELF2-AS1	1.86e-04	171	137	5	dcb15bc54aeea06ef8f07f1134f3ff1e21ac0e4f
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SPTBN2 EYA1 PPM1H ITPR2 SIGLEC10	1.92e-04	172	137	5	7fb43b3938b9a3b6935ec22d9d853e7d47b82b3c
ToppCell	Mesenchymal_cells-Osteo-CAR\|Mesenchymal_cells / Lineage and Cell class	TMC3 NAV2 ST6GALNAC4 MTARC1 IQCG	2.02e-04	174	137	5	430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|368C / Donor, Lineage, Cell class and subclass (all cells)	KIF15 ASPM MYEOV POLQ DNMT3B	2.08e-04	175	137	5	74800a10f5ff25d5414fbccb0668f92ff077d1cc
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 THSD7A C2CD4C KIAA1671 TIE1	2.13e-04	176	137	5	77516048aefbe1f48e825052756df0c310c1c486
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 THSD7A C2CD4C KIAA1671 TIE1	2.13e-04	176	137	5	96779273b94345250cf53ba671203345b43d9e00
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	KIF15 ASPM MYEOV POLQ DNMT3B	2.19e-04	177	137	5	844017225e9039d1bc621a9630a30c2e9a51b36d
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KIF15 ASPM MYEOV POLQ DNMT3B	2.19e-04	177	137	5	26c25d10aa511b64cc7db43a8deea7b5d31bca96
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Tuft\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ITPR2 LMAN1L KCNQ4 CFAP61 MTARC1	2.25e-04	178	137	5	f17c3b7bb562ac24c6a03fe3c9ba94c2b434c141
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-granulocyte-monocyte_progenitor\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACHE SLC5A2 KIF15 PRSS50 POLQ	2.30e-04	179	137	5	804aa3899585fc7e662eff9f6d41f48655f16dd6
ToppCell	367C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SH2B3 ATG7 SLC25A43 TIE1 AP5B1	2.30e-04	179	137	5	5aa8465e943b6b666c7f8b1937fcc3764bfe91f6
ToppCell	Control-Developping_Plasmablast\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	KIF15 GLDC ASPM POLQ CTSG	2.30e-04	179	137	5	9383568f78b07b8cca72ece5d15fea209aa54ea9
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN2 CHSY1 ANKRD13A ARHGAP44 NR3C2	2.30e-04	179	137	5	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	facs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A25 ARHGAP44 PPM1L BRINP2 KLHDC8B	2.36e-04	180	137	5	a37cc885fe3f6cb9df69d43358064c83c18412e7
ToppCell	facs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A25 ARHGAP44 PPM1L BRINP2 KLHDC8B	2.36e-04	180	137	5	63a6d532b16b8b15c7c9102148d7297ee3afd641
ToppCell	3'_v3-bone_marrow-Mast\|bone_marrow / Manually curated celltypes from each tissue	LINC00473 THSD7A SPTBN2 PPM1H CTSG	2.36e-04	180	137	5	b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCell	3'_v3-bone_marrow-Mast-Mast_cells\|bone_marrow / Manually curated celltypes from each tissue	LINC00473 THSD7A SPTBN2 PPM1H CTSG	2.43e-04	181	137	5	30ec4635474ee0f0ea1415ec0ba7f008d97e8c1a
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK5 THSD7A KIAA1671 TIE1 CTSG	2.43e-04	181	137	5	0ba91575fe8851788cebc4cf5a6d76680bf586c5
ToppCell	severe-Myeloid-Neutrophils_1\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	RNF149 ALDH1A2 CSF3R SIGLEC10 ARAP1	2.55e-04	183	137	5	60a6112aa4fc4f5debda4c7e81b37539ba2e4e6e
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B PCSK5 THSD7A TIE1 RP1L1	2.55e-04	183	137	5	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LINC00473 THSD7A SPTBN2 ARHGAP44 NR3C2	2.55e-04	183	137	5	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	10x5'v1-week_17-19-Hematopoietic-MK-MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	RYR2 KCNQ4 PRSS50 MYEOV FERMT3	2.55e-04	183	137	5	9c66a40c355387f805dbdca4162dd05af5c1d8d4
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK5 THSD7A GSTA4 ARHGAP44 NR3C2	2.55e-04	183	137	5	351d575339038bd4a66f408da518c567444208e8
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GEMIN5 KIF15 ASPM POLQ CTSG	2.62e-04	184	137	5	a8c6028d745aaa6ee7842259238694cb50ce0526
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GEMIN5 KIF15 ASPM POLQ CTSG	2.62e-04	184	137	5	081d045f3bc98a36f342de7d50f39c9a888dd7eb
ToppCell	Control-Myeloid_G-immature_Neutrophil\|Control / Disease group, lineage and cell class	GEMIN5 KIF15 ASPM POLQ CTSG	2.62e-04	184	137	5	45f873236f7e90fb78c8e291d3b5b92d121acec9
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	GEMIN5 KIF15 ASPM POLQ CTSG	2.62e-04	184	137	5	84c20730cd92b9aaa50077d7b625e37e7f9e91d2
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	LRP12 MYCBP2 ITPR2 TENM3 ALDH1L2	2.62e-04	184	137	5	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Lymphocytic-T_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSCB RPGRIP1 ASPM CTSG DNMT3B	2.62e-04	184	137	5	185b49630da61cbf45c0926d1b992943296d2a54
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK5 THSD7A TIE1 ARHGAP44 IQCG	2.62e-04	184	137	5	f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK5 THSD7A TIE1 ARHGAP44 IQCG	2.62e-04	184	137	5	8bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCell	COPD-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	RNF149 CHSY1 ALDH1A2 CSF3R PPM1L	2.62e-04	184	137	5	ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GEMIN5 KIF15 ASPM POLQ CTSG	2.62e-04	184	137	5	d31d4116d1d196633784863781fa45673607a421
ToppCell	Control-immature_Neutrophil-\|Control / Disease condition and Cell class	GEMIN5 KIF15 ASPM POLQ CTSG	2.62e-04	184	137	5	c4e8ba82a6aa76c46f05a71d5f1c7926555318cf
ToppCell	Control-immature_Neutrophil\|Control / Disease condition and Cell class	GEMIN5 KIF15 ASPM POLQ CTSG	2.62e-04	184	137	5	2fdae5c6b3eb2232881d933a8c1061fda3623016
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN2 SLC25A25 WNK1 GLDC NR3C2	2.75e-04	186	137	5	08632045d499e61dd96ff29a5a9a208afe58dc58
ToppCell	wk_15-18-Mesenchymal-Mesothelial-Early_mesothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ASPHD1 SMYD1 WNT2B ITGA3 ALDH1A2	2.75e-04	186	137	5	ae4b6ecfc1850c0a01a11b9dd9718880f2a24fe0
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B THSD7A KIAA1671 TIE1 ARHGAP44	2.75e-04	186	137	5	1e67bfb248366d7395efdd2d5e70a97bdb2e68af
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|bone_marrow / Manually curated celltypes from each tissue	TNFSF13 KIF15 CSF3R ASPM POLQ	2.75e-04	186	137	5	e82d5e7a976b9cfa2b4640c7a7cd1cfea19c4806
Drug	camphene	PCSK5 EYA1 FARP2 MCAT	4.01e-07	11	137	4	CID000006616
Drug	Debrisoquin sulfate [581-88-4]; Up 200; 9uM; MCF7; HT_HG-U133A	ASPHD1 SPTAN1 WNK1 RYR2 GSTA4 NCOR2 ARHGAP44 SLC25A23 NOL8	3.00e-06	196	137	9	5288_UP
Disease	small vessel stroke	SH2B3 ATG7 AFDN-DT SH3PXD2A NFXL1 ANTXR1	4.77e-06	96	132	6	EFO_1001504
Disease	macula measurement	STAT2 SLC6A20 NAV2 TJP2 MYEOV ROBO3	2.14e-04	189	132	6	EFO_0008375
Disease	glucagon measurement, glucose tolerance test	MACF1 UTP3	2.94e-04	6	132	2	EFO_0004307, EFO_0008463
Disease	eye disease (implicated_via_orthology)	EYA1 RP1L1	2.94e-04	6	132	2	DOID:5614 (implicated_via_orthology)
Disease	serum albumin measurement	SH2B3 TNFSF13 MADD FARP2 ALDH1A2 FCGRT MACF1 MYEOV DAGLA MTARC1	3.43e-04	592	132	10	EFO_0004535
Disease	cortical thickness	GPBAR1 ABCF3 MYCBP2 SPTBN2 LAMA1 CHSY1 EYA1 LMAN1L ALDH1A2 SH3PXD2A NAV2 MACF1 MYEOV KDM4B	4.77e-04	1113	132	14	EFO_0004840
Disease	pseudohypoaldosteronism (is_implicated_in)	WNK1 NR3C2	5.46e-04	8	132	2	DOID:4479 (is_implicated_in)
Disease	Pseudohypoaldosteronism, Type I	WNK1 NR3C2	8.73e-04	10	132	2	C0268436
Disease	Pseudohypoaldosteronism	WNK1 NR3C2	8.73e-04	10	132	2	C0033805
Disease	Hyperpotassemia and Hypertension, Familial	WNK1 NR3C2	8.73e-04	10	132	2	C2713447
Disease	Pseudohypoaldosteronism, Type I, Autosomal Recessive	WNK1 NR3C2	8.73e-04	10	132	2	C1449843
Disease	Pseudohypoaldosteronism, Type II	WNK1 NR3C2	8.73e-04	10	132	2	C1449844
Disease	Pseudohypoaldosteronism, Type I, Autosomal Dominant	WNK1 NR3C2	8.73e-04	10	132	2	C1449842
Disease	cholesteryl ester 20:4 measurement	ALDH1A2 NAV2 DAGLA	1.01e-03	44	132	3	EFO_0010348
Disease	X-11315 measurement	MROH6 SLC6A20	1.06e-03	11	132	2	EFO_0021223
Disease	migraine disorder	AMBRA1 EYA1 NCOR2 EHMT1 TJP2 MACF1 TRPM8	1.16e-03	357	132	7	MONDO_0005277
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	PCSK5 SH2B3 ALDH1A2 MTARC1	1.16e-03	102	132	4	EFO_0004329, EFO_0004611
Disease	systolic blood pressure, alcohol consumption measurement	SH2B3 LMAN1L RP1L1	1.23e-03	47	132	3	EFO_0006335, EFO_0007878
Disease	level of Phosphatidylinositol (18:0_20:3) in blood serum	ALDH1A2 DAGLA	1.27e-03	12	132	2	OBA_2045157
Disease	phosphoglycerides measurement	NCOR2 ALDH1A2 MTARC1	1.31e-03	48	132	3	EFO_0022291
Disease	omega-6:omega-3 polyunsaturated fatty acid ratio	ALDH1A2 CFAP61 DAGLA	1.47e-03	50	132	3	EFO_0010732
Disease	cholesteryl esters to total lipids in IDL percentage	ALDH1A2 MACF1 MTARC1	1.47e-03	50	132	3	EFO_0022247
Disease	mean arterial pressure, alcohol consumption measurement	SH2B3 LMAN1L RP1L1	1.65e-03	52	132	3	EFO_0006340, EFO_0007878
Disease	level of Phosphatidylcholine (18:1_18:2) in blood serum	ALDH1A2 DAGLA	1.74e-03	14	132	2	OBA_2045100
Disease	level of Phosphatidylethanolamine (18:2_0:0) in blood serum	ALDH1A2 DAGLA	1.74e-03	14	132	2	OBA_2045143
Disease	testosterone measurement	VIL1 TNFSF13 ACHE WNT2B IQCN EYA1 REXO1 FARP2 NCOR2 FCGRT SH3PXD2A FGD1 MACF1 ARAP1	1.75e-03	1275	132	14	EFO_0004908
Disease	phosphatidylcholine measurement	NCOR2 ALDH1A2 MACF1 MYEOV DAGLA MTARC1	1.79e-03	284	132	6	EFO_0010226
Disease	Acute Cerebrovascular Accidents	SH2B3 WNT2B SH3PXD2A	1.84e-03	54	132	3	C0751956
Disease	white matter microstructure measurement	SH2B3 TMCO6 ALDH1A2 TIE1 SH3PXD2A NAV2 ROBO3	1.92e-03	390	132	7	EFO_0005674
Disease	tumor necrosis factor measurement	SH2B3 ALDH1A2	2.01e-03	15	132	2	EFO_0010834
Disease	level of Triacylglycerol (53:3) in blood serum	ALDH1A2 MTARC1	2.01e-03	15	132	2	OBA_2045165
Disease	platelet component distribution width	CAPN14 SH2B3 IRS1 WNK1 LMAN1L NCOR2 ANKDD1A ANTXR1 MACF1 NR3C2	2.15e-03	755	132	10	EFO_0007984
Disease	pro-hydroxy-pro measurement	NR3C2 ALK	2.29e-03	16	132	2	EFO_0021132
Disease	Rolandic epilepsy	ALDH1L2 NR3C2	2.29e-03	16	132	2	Orphanet_1945
Disease	cholesteryl esters to total lipids in large HDL percentage	MADD NCOR2 ALDH1A2	2.37e-03	59	132	3	EFO_0022248
Disease	age at menopause	WNT2B GEMIN5 FRYL UROC1 TNRC18 CSF3R	2.44e-03	302	132	6	EFO_0004704
Disease	triglycerides to total lipids in large HDL percentage	MADD NCOR2 ALDH1A2	2.49e-03	60	132	3	EFO_0022330
Disease	cholesterol to total lipids in IDL percentage	ALDH1A2 MACF1 MTARC1	2.49e-03	60	132	3	EFO_0022233
Disease	free cholesterol to total lipids in medium HDL percentage	MADD ALDH1A2 MTARC1	2.49e-03	60	132	3	EFO_0022282
Disease	Cerebrovascular accident	SH2B3 WNT2B SH3PXD2A	2.73e-03	62	132	3	C0038454
Disease	level of Phosphatidylcholine (15:0_18:2) in blood serum	ALDH1A2 DAGLA	2.90e-03	18	132	2	OBA_2045065
Disease	Headache	TJP2 MACF1 TRPM8	2.99e-03	64	132	3	HP_0002315
Disease	Seizures	ACHE KCNK4 GLDC MACF1 TBCD	3.04e-03	218	132	5	C0036572
Disease	primary ciliary dyskinesia (implicated_via_orthology)	PCSK5 GAS2L2	3.23e-03	19	132	2	DOID:9562 (implicated_via_orthology)
Disease	age at onset, smoking initiation	MYCBP2 ITPR2	3.23e-03	19	132	2	EFO_0004847, EFO_0005670
Disease	brain measurement, neuroimaging measurement	ABCF3 WNT2B ALDH1A2 SH3PXD2A NAV2 MACF1 MYEOV DNMT3B	3.40e-03	550	132	8	EFO_0004346, EFO_0004464
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	ALDH1A2 MACF1 MTARC1	3.40e-03	67	132	3	EFO_0008595, EFO_0020946
Disease	exercise test	RYR2 ALDH1A2	3.58e-03	20	132	2	EFO_0004328
Disease	cataract	THSD7A PLEKHH3 ST6GALNAC4 MYEOV	3.76e-03	141	132	4	MONDO_0005129
Disease	saturated fatty acids to total fatty acids percentage	ALDH1A2 MTARC1	3.94e-03	21	132	2	EFO_0022305
Disease	level of Phosphatidylcholine (16:1_18:2) in blood serum	ALDH1A2 DAGLA	3.94e-03	21	132	2	OBA_2045083
Disease	metabolite measurement, diet measurement	ALDH1A2 GLDC DAGLA	4.01e-03	71	132	3	EFO_0004725, EFO_0008111
Disease	Agents acting on the renin-angiotensin system use measurement	SH2B3 ATG7 WNT2B REXO1 TJP2 FERMT3	4.06e-03	335	132	6	EFO_0009931
Disease	stroke	SH2B3 WNT2B ALDH1A2 SH3PXD2A	4.06e-03	144	132	4	EFO_0000712
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	MADD ALDH1A2 MACF1 MTARC1	4.06e-03	144	132	4	EFO_0004611, EFO_0020943
Disease	sexual dimorphism measurement	PCSK5 VIL1 CHSY1 FRYL EYA1 MADD FARP2 NCOR2 ALDH1A2 AP5B1 MACF1 MTARC1	4.10e-03	1106	132	12	EFO_0021796
Disease	total blood protein measurement	SH2B3 TNFSF13 NCOR2 FCGRT SH3PXD2A MACF1 ARAP1	4.17e-03	449	132	7	EFO_0004536

Protein segments in the cluster

Peptide	Gene	Start	Entry
AAMSGLQSGRRWRPQ	nan	51	Q9H8V8
PWATVGMGEARRRAT	ACHE	266	P22303
GGWRMRVALARALFI	ABCF2	231	Q9UG63
WVNVVVGRMTGIDRA	CFAP61	736	Q8NHU2
MATAERRALGIGFQW	ANTXR1	1	Q9H6X2
MGRGARQKLLGRSWS	DNMT3B	821	Q9UBC3
WQLEGSSVVTMGGRR	HAAO	231	P46952
GSVWRRMDASERGRL	ALDH1A2	91	O94788
RWAVLGSVRMGGARS	AFDN-DT	51	Q9Y6Z5
GEWGRMNARERGRLM	ALDH1L2	496	Q3SY69
REFSGGWRMRLALAR	ABCF3	326	Q9NUQ8
MTRGRAWGMRRAAAG	ANKRD60	1	Q9BZ19
RILWGRERGARAMGA	AMBRA1	11	Q9C0C7
MWFLERLRGSGENGA	C2CD4C	6	Q8TF44
MANRRVGRGCWEVSP	ASPM	1	Q8IZT6
TMREGRWEKRSTAGG	CAPN14	351	A8MX76
QAWWRGTMIRREIGG	IQCG	401	Q9H095
RGAMVIQATWRGYRV	IQCN	951	Q9H0B3
VQRAAMGWRLSARSG	ITPR2	1571	Q14571
MASSIRRGRGAWTRL	PCDHA2	1	Q9Y5H9
LLGFENMSWIRGRRS	ANKRD13A	161	Q8IZ07
GLLEHGRNWSAIARM	NCOR2	626	Q9Y618
IRDWRLMGRLVGTEQ	KIAA0100	1036	Q14667
SRMTQGLRWVRFTLG	LRP12	731	Q9Y561
EGLDMERRWGQVSQA	NR3C2	11	P08235
RGVQRDTMWRIFTGS	MADD	216	Q8WXG6
LMAAGDGVRQSWEIR	MPV17L2	36	Q567V2
AMGLRSGNLRDRFWL	MTARC1	81	Q5VT66
SGGWRNRRVASTSMN	KIF15	216	Q9NS87
GSVQRASLIWEARGM	KIAA1671	791	Q9BY89
GSVAWRVARGEMGLQ	NGLY1	461	Q96IV0
MEASWRQVAGGRGRS	NFXL1	1	Q6ZNB6
CRGQLQGLVSWGMER	KLK14	226	Q9P0G3
RALTWRQARAQAGAM	GPBAR1	216	Q8TDU6
WLRVVSRRTRAEMGG	KCNK4	256	Q9NYG8
WEVEVQMRVTGLGRR	LMAN1L	91	Q9HAT1
RRLAALLGSQGMRFW	CELF2-AS1	56	Q8N7Q2
CRAMWGLAARRGRAE	CELF2-AS1	76	Q8N7Q2
RYSWAGMGRVRRAAQ	ASPHD1	156	Q5U4P2
RMDRRGGTWKLLGSV	KCNQ4	216	P56696
TAAAVGGALLWRRMR	FCGRT	311	P55899
VRMGRRGLGSVFVWA	PCSK5	296	Q92824
QVLWSGSEDQRRMVG	ITGA3	146	P26006
MSAAQGWDRNRRRGG	KLHDC10	1	Q6PID8
RELMVTSRRWLRGEG	FRYL	1341	O94915
ATGVRGGVDWMRKLA	EYA1	421	Q99502
NLRGGALQMTTDRRW	KDM4B	801	O94953
VEALGGWRMGVRRTG	MYEOV	266	Q96EZ4
VTCMEQAGGWRRLVG	MROH6	321	A6NGR9
MGPLSRDAWAQRLGA	AP5B1	1	Q2VPB7
GSLSLRRGMWAAAVV	ASIC3	36	Q9UHC3
RGVGSNMSRNSWEAR	NOL8	1131	Q76FK4
RAAWQESTGVEMGRL	IRS1	951	P35568
RILRSTVMVRVGGGW	MACF1	7161	Q9UPN3
MSVRVARVAWVRGLG	MCAT	1	Q8IVS2
WMPGLNERTRQRGDF	PIK3R2	56	O00459
NGRGRMESVRWVLAA	GSTA4	11	O15217
LGCNVARTLMGWGVR	ATG7	366	O95352
MELSAAAGRRRQAPW	LINC00473	1	A8K010
ILRNHVMVRVGGGWD	GAS2L2	246	Q8NHY3
RRNMRTIWVTGRKGL	POLQ	856	O75417
MAWAGSRRVPAGTRA	COQ10A	1	Q96MF6
MAATRCLRWGLSRAG	MRPL58	1	Q14197
TWRMEQNGRATGFLL	CSF3R	476	Q99062
MGLRSGNLRDRFWLV	MTARC2	81	Q969Z3
MPGIVVFRRRWSVGS	DAGLA	1	Q9Y4D2
MRLGLRNTEWPGRTQ	FPGS	351	Q05932
RWERRATLPQAAMGV	KLHDC8B	106	Q8IXV7
LCTVAGWGRVSMRRG	CTSG	141	P08311
GWGRVSMRRGTDTLR	CTSG	146	P08311
SNGGRIMRSWETNIG	EMC1	101	Q8N766
RWMEVIQGASSSAGR	FARP2	1016	O94887
WRALQRGREGRTMTS	FLAD1	86	Q8NFF5
RGMDVNSQRALLVWG	PNMA1	11	Q8ND90
MVGRSRRRGAAKWAA	UTP3	1	Q9NQZ2
GWRIERTREGDSMAL	RYR2	2786	Q92736
ARLQLYRTRDMGWGV	EHMT1	1126	Q9H9B1
YRTRDMGWGVRSLQD	EHMT1	1131	Q9H9B1
MLALRVARGSWGALR	CRLS1	1	Q9UJA2
MEWRGRRVALKASNG	FSCN2	336	O14926
MWRGRAGALLRVWGF	HSCB	1	Q8IWL3
AREMDGRRVLGRFWS	RPUSD3	6	Q6P087
LRRNRVAGGWETQYM	REXO1	1001	Q8N1G1
ARRGQKAGWRQRLSM	RPGRIP1	101	Q96KN7
SRPGMGLRRNNTWAL	TMC3	456	Q7Z5M5
TAAAVLGGWKRLRGM	PLEKHH3	626	Q7Z736
LWNDGRIMGFVSRSQ	STAT2	571	P52630
MGLQARRWASGSRGA	THSD7A	1	Q9UPZ6
DRAGGRSWCLRRVGM	RNF8	11	O76064
MSANGAVWGRVRSRL	NDUFAF8	1	A1L188
MRRGRVAFLWDLGSG	LAMA1	2171	P25391
EELQRRWMAVLGRAG	FGD1	906	P98174
RWMAVLGRAGRGDTF	FGD1	911	P98174
QTGSWRRGMTAQVGI	NAV2	1056	Q8IVL1
LAARIMWRVEREGTG	SMYD1	106	Q8NB12
FNGSWRVQGILAMSR	PPM1L	251	Q5SGD2
DRLSSGRWMGKDGQQ	MYCBP2	4241	O75592
MATWRRDGRLTGGQR	SLC25A43	1	Q8WUT9
RGAGTAVQMRVWRER	SCRIB	801	Q14160
GVRVMDTNWVARRGS	ARHGAP44	516	Q17R89
GQRMRQGSIGAWRTI	SLC6A20	66	Q9NP91
RWMGVNARRGLLILG	PNMA6A	11	P0CW24
MRWQCGTRFRGLRPA	BRINP2	1	Q9C0B6
RMSWLIRGVLRGNVS	ALK	551	Q9UM73
VAIGRRDLAGWSTMA	ANKDD1A	486	Q495B1
GERRLDFMGWLGAIQ	ARAP1	936	Q96P48
MAARGRRAWLSVLLG	CHSY1	1	Q86X52
RRNGLSESEGVMWVG	NLRP9	416	Q7RTR0
TQMIREGGARSLWRG	SLC25A25	231	Q6KCM7
LIGMGKARGRNQTWD	TNRC18	1586	O15417
SGAQQFRMRVRWGIQ	FYTTD1	61	Q96QD9
MAWRRREASVGARGV	RNF149	1	Q8NC42
QWNGPESTRMERLRG	VIL1	176	P09327
WGQGRHMDRVLGGRT	ST6GALNAC4	151	Q9H4F1
DRADFWRMRGQRSGV	TJP2	681	Q9UDY2
ELGRMWESRQGRLAQ	SPTBN2	1156	O15020
LVGEDTLLWSRRMGR	RP1L1	331	Q8IWN7
VIGVGLWSMCRTNRG	SLC5A2	36	P31639
MRARGVLKDRGWRIS	PPM1H	476	Q9ULR3
GQRSFWAQLGMALTR	TLR9	1001	Q9NR96
EGRARLMLSWDVSNG	UROC1	616	Q96N76
LWRMVPAGRAARGQA	SOX12	186	O15370
FRMRASIQGLGDWSN	TIE1	716	P35590
LDRRWTLGGMVNRQH	SH3PXD2A	251	Q5TCZ1
SDFRDLMSWINGIRG	SPTAN1	1346	Q13813
RSAAGWARSAMLRGL	ROBO3	821	Q96MS0
RMVEANSRGVVWGIG	TECPR1	771	Q7Z6L1
IRIWSCSRGRGVMIL	GEMIN5	251	Q8TEQ6
MWSRRQGRLRPTVCG	TMCO6	1	Q96DC7
MDSGARWQRGRLALR	SH2B3	211	Q9UQQ2
AMRLWGRGVKSGRSS	TENM3	131	Q9P273
ARWMAGCRLASKGRT	FERMT3	446	Q86UX7
GLLWGIARQGMRCSE	UNC13B	496	O14795
SMVLEGGIRSLWRGN	SLC25A23	231	Q9BV35
VRWSAAKGIGRMAGR	TBCD	376	Q9BTW9
NWARDAMNLSGRRGS	WNK1	2256	Q9H4A3
VWMVAFGVARQGILR	TRPM8	876	Q7Z2W7
LGGSQAMDGRFWIRV	SIGLEC10	11	Q96LC7
MGRWCQTVARGQRPR	PRSS50	1	Q9UI38
NSIIMWDIGGRKGRT	WDFY1	221	Q8IWB7
VMWQPALRRGRGLQA	TNFSF13	136	O75888
DIMRSVGEGAREWIR	WNT2B	91	Q93097
MQSCARAWGLRLGRG	GLDC	1	P23378