Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	antigen binding	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9 IGHV3-43D IGHV1-58	1.08e-07	190	41	7	GO:0003823
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	1.06e-04	231	41	5	GO:0005085
GeneOntologyBiologicalProcess	immunoglobulin mediated immune response	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9 IGHV3-43D IGHV1-58	3.68e-07	235	41	7	GO:0016064
GeneOntologyBiologicalProcess	B cell mediated immunity	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9 IGHV3-43D IGHV1-58	4.75e-07	244	41	7	GO:0019724
GeneOntologyBiologicalProcess	clathrin-dependent synaptic vesicle endocytosis	ITSN1 ITSN2	3.86e-06	2	41	2	GO:0150007
GeneOntologyBiologicalProcess	lymphocyte mediated immunity	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9 IGHV3-43D IGHV1-58	2.62e-05	449	41	7	GO:0002449
GeneOntologyBiologicalProcess	regulation of cell morphogenesis	TAOK2 FBXW8 WLS ARHGEF7 ITSN2 SH3KBP1	2.74e-05	302	41	6	GO:0022604
GeneOntologyBiologicalProcess	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9 IGHV3-43D IGHV1-58	3.14e-05	462	41	7	GO:0002460
GeneOntologyBiologicalProcess	leukocyte mediated immunity	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9 IGHV3-43D IGHV1-58	1.26e-04	576	41	7	GO:0002443
GeneOntologyBiologicalProcess	synaptic vesicle recycling via endosome	ITSN1 ITSN2	1.72e-04	10	41	2	GO:0036466
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	TAOK2 DDR1 ALS2 FBXW8 WLS ARHGEF7 CD2AP ITSN2	1.78e-04	819	41	8	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	TAOK2 DDR1 ALS2 FBXW8 WLS ARHGEF7 CD2AP ITSN2	1.89e-04	826	41	8	GO:0048858
GeneOntologyBiologicalProcess	immune effector process	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9 IGHV3-43D IGHV1-58 VAV2	2.46e-04	859	41	8	GO:0002252
GeneOntologyBiologicalProcess	positive regulation of growth hormone secretion	ARHGEF7 ITSN1	2.51e-04	12	41	2	GO:0060124
GeneOntologyBiologicalProcess	synapse organization	TAOK2 NEDD9 LGMN ALS2 ARHGEF7 ITSN1 CD2AP	3.63e-04	685	41	7	GO:0050808
GeneOntologyBiologicalProcess	postsynapse organization	TAOK2 NEDD9 LGMN ARHGEF7 ITSN1	3.73e-04	313	41	5	GO:0099173
GeneOntologyBiologicalProcess	positive regulation of cell projection organization	NEDD9 DDR1 FBXW8 WLS ARHGEF7 KCTD17	4.04e-04	494	41	6	GO:0031346
GeneOntologyBiologicalProcess	synaptic vesicle endosomal processing	ITSN1 ITSN2	4.55e-04	16	41	2	GO:0099532
GeneOntologyBiologicalProcess	cell morphogenesis	TAOK2 DDR1 ALS2 FBXW8 WLS ARHGEF7 CD2AP ITSN2 SH3KBP1	4.61e-04	1194	41	9	GO:0000902
GeneOntologyBiologicalProcess	cell surface receptor protein tyrosine kinase signaling pathway	NEDD9 LGMN DDR1 KL ARHGEF7 VAV2 CD2AP	6.10e-04	747	41	7	GO:0007169
GeneOntologyBiologicalProcess	regulation of growth hormone secretion	ARHGEF7 ITSN1	6.45e-04	19	41	2	GO:0060123
GeneOntologyBiologicalProcess	immunological synapse formation	NEDD9 CD2AP	6.45e-04	19	41	2	GO:0001771
GeneOntologyBiologicalProcess	growth hormone secretion	ARHGEF7 ITSN1	8.68e-04	22	41	2	GO:0030252
GeneOntologyBiologicalProcess	neuron projection morphogenesis	TAOK2 DDR1 ALS2 FBXW8 WLS CD2AP ITSN2	9.27e-04	802	41	7	GO:0048812
GeneOntologyBiologicalProcess	regulation of cytoskeleton organization	TAOK2 NEDD9 DNAI3 ARHGEF7 CD2AP CAPN10	9.29e-04	579	41	6	GO:0051493
GeneOntologyBiologicalProcess	actin cytoskeleton organization	TAOK2 NEDD9 DNAI3 ARHGEF7 CD2AP SH3KBP1 CAPN10	9.34e-04	803	41	7	GO:0030036
GeneOntologyBiologicalProcess	regulation of actin cytoskeleton organization	TAOK2 NEDD9 DNAI3 CD2AP CAPN10	9.41e-04	384	41	5	GO:0032956
GeneOntologyBiologicalProcess	positive regulation of secretion by cell	WLS ARHGEF7 ITSN1 CD2AP CAPN10	1.18e-03	404	41	5	GO:1903532
GeneOntologyBiologicalProcess	adaptive immune response	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9 IGHV3-43D IGHV1-58	1.20e-03	838	41	7	GO:0002250
GeneOntologyCellularComponent	immunoglobulin complex	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9 IGHV3-43D IGHV1-58	3.75e-08	166	42	7	GO:0019814
GeneOntologyCellularComponent	cell leading edge	NEDD9 ALS2 WLS ARHGEF7 ITSN1 CD2AP	4.59e-04	500	42	6	GO:0031252
Domain	SH3_2	ARHGEF7 VAV2 ITSN1 CD2AP ITSN2 SH3KBP1	1.16e-08	86	35	6	IPR011511
Domain	SH3_2	ARHGEF7 VAV2 ITSN1 CD2AP ITSN2 SH3KBP1	1.16e-08	86	35	6	PF07653
Domain	SH3_1	NEDD9 ARHGEF7 VAV2 ITSN1 CD2AP ITSN2 SH3KBP1	1.94e-08	164	35	7	PF00018
Domain	SH3	NEDD9 ARHGEF7 VAV2 ITSN1 CD2AP ITSN2 SH3KBP1	1.28e-07	216	35	7	PS50002
Domain	SH3	NEDD9 ARHGEF7 VAV2 ITSN1 CD2AP ITSN2 SH3KBP1	1.28e-07	216	35	7	SM00326
Domain	SH3_domain	NEDD9 ARHGEF7 VAV2 ITSN1 CD2AP ITSN2 SH3KBP1	1.45e-07	220	35	7	IPR001452
Domain	DH_2	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	1.90e-07	70	35	5	PS50010
Domain	RhoGEF	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	1.90e-07	70	35	5	PF00621
Domain	DH-domain	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	2.04e-07	71	35	5	IPR000219
Domain	-	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	2.04e-07	71	35	5	1.20.900.10
Domain	SH3_9	NEDD9 ITSN1 CD2AP ITSN2 SH3KBP1	3.28e-07	78	35	5	PF14604
Domain	GDS_CDC24_CS	ALS2 ARHGEF7 VAV2 ITSN1	8.11e-07	39	35	4	IPR001331
Domain	PH_13	ITSN1 ITSN2	3.41e-06	2	35	2	PF16652
Domain	DH_1	ALS2 ARHGEF7 VAV2 ITSN1	5.69e-06	63	35	4	PS00741
Domain	RhoGEF	ARHGEF7 VAV2 ITSN1 ITSN2	7.73e-06	68	35	4	SM00325
Domain	EF-hand_4	ITSN1 ITSN2	1.52e-04	10	35	2	PF12763
Domain	PH	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	1.59e-04	278	35	5	SM00233
Domain	PH_DOMAIN	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	1.61e-04	279	35	5	PS50003
Domain	PH_domain	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	1.64e-04	280	35	5	IPR001849
Domain	EH	ITSN1 ITSN2	1.86e-04	11	35	2	PS50031
Domain	EH	ITSN1 ITSN2	1.86e-04	11	35	2	SM00027
Domain	EH_dom	ITSN1 ITSN2	1.86e-04	11	35	2	IPR000261
Domain	MORN	ALS2 JPH4	3.06e-04	14	35	2	SM00698
Domain	-	DDR1 FBXO17 F5	3.43e-04	73	35	3	2.60.120.260
Domain	MORN	ALS2 JPH4	3.53e-04	15	35	2	PF02493
Domain	MORN	ALS2 JPH4	3.53e-04	15	35	2	IPR003409
Domain	FA58C	DDR1 F5	7.01e-04	21	35	2	SM00231
Domain	FA58C_3	DDR1 F5	7.01e-04	21	35	2	PS50022
Domain	FA58C_1	DDR1 F5	7.01e-04	21	35	2	PS01285
Domain	FA58C_2	DDR1 F5	7.01e-04	21	35	2	PS01286
Domain	Galactose-bd-like	DDR1 FBXO17 F5	7.19e-04	94	35	3	IPR008979
Domain	-	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	7.59e-04	391	35	5	2.30.29.30
Domain	PH	ARHGEF7 VAV2 ITSN1 ITSN2	8.55e-04	229	35	4	PF00169
Domain	F5_F8_type_C	DDR1 F5	9.18e-04	24	35	2	PF00754
Domain	FA58C	DDR1 F5	9.18e-04	24	35	2	IPR000421
Domain	TRYPSIN_HIS	PRSS42P TPSG1 TMPRSS7	9.38e-04	103	35	3	IPR018114
Domain	TRYPSIN_SER	PRSS42P TPSG1 TMPRSS7	1.02e-03	106	35	3	PS00135
Domain	TRYPSIN_HIS	PRSS42P TPSG1 TMPRSS7	1.05e-03	107	35	3	PS00134
Domain	PH_dom-like	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	1.11e-03	426	35	5	IPR011993
Domain	Peptidase_S1A	PRSS42P TPSG1 TMPRSS7	1.23e-03	113	35	3	IPR001314
Domain	TRYPSIN_DOM	PRSS42P TPSG1 TMPRSS7	1.29e-03	115	35	3	PS50240
Domain	Tryp_SPc	PRSS42P TPSG1 TMPRSS7	1.35e-03	117	35	3	SM00020
Domain	Trypsin	PRSS42P TPSG1 TMPRSS7	1.49e-03	121	35	3	PF00089
Domain	Trypsin_dom	PRSS42P TPSG1 TMPRSS7	1.49e-03	121	35	3	IPR001254
Domain	Peptidase_S1_PA	PRSS42P TPSG1 TMPRSS7	1.56e-03	123	35	3	IPR009003
Domain	F-box-like	FBXW8 FBXO17	3.07e-03	44	35	2	PF12937
Domain	FBOX	FBXW8 FBXO17	4.27e-03	52	35	2	SM00256
Domain	CH	ARHGEF7 VAV2	6.59e-03	65	35	2	SM00033
Domain	F-box	FBXW8 FBXO17	6.99e-03	67	35	2	PF00646
Pathway	PID_CDC42_REG_PATHWAY	ARHGEF7 VAV2 ITSN1 ITSN2	2.41e-07	30	26	4	M83
Pathway	PID_ERBB1_INTERNALIZATION_PATHWAY	ARHGEF7 ITSN1 SH3KBP1	5.67e-05	41	26	3	M214
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	ARHGEF7 VAV2 ITSN1	1.16e-04	52	26	3	MM14743
Pathway	REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	IGHV3-43 IGHV3-20 SH3KBP1	1.23e-04	53	26	3	MM15716
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	MIB2 ARHGEF7 VAV2 ITSN1	1.24e-04	142	26	4	MM15431
Pathway	REACTOME_VESICLE_MEDIATED_TRANSPORT	IGHV3-43 ALS2 IGHV3-20 F5 ITSN1 ITSN2 SH3KBP1	1.25e-04	645	26	7	MM15232
Pathway	REACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION	IGHV3-43 IGHV3-20 VAV2	1.61e-04	58	26	3	MM14914
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	ARHGEF7 VAV2 ITSN1	1.69e-04	59	26	3	M11215
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	MIB2 ARHGEF7 VAV2 ITSN1	1.70e-04	154	26	4	M27697
Pathway	REACTOME_FCERI_MEDIATED_MAPK_ACTIVATION	IGHV3-43 IGHV3-20 VAV2	1.78e-04	60	26	3	MM14913
Pathway	REACTOME_EPH_EPHRIN_SIGNALING	ARHGEF7 VAV2 ITSN1	2.26e-04	65	26	3	MM14911
Pathway	REACTOME_ADAPTIVE_IMMUNE_SYSTEM	LGMN IGHV3-43 FBXW8 MIB2 FBXO17 IGHV3-20 SH3KBP1	2.45e-04	719	26	7	MM14540
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	ARHGEF7 VAV2 ITSN1	2.81e-04	70	26	3	MM14824
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	ARHGEF7 VAV2 ITSN1	3.58e-04	76	26	3	M19832
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	ARHGEF7 VAV2 ITSN1	3.72e-04	77	26	3	MM15044
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	ARHGEF7 VAV2 ITSN1	4.16e-04	80	26	3	M800
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	ARHGEF7 VAV2 ITSN1	4.98e-04	85	26	3	MM14746
Pathway	REACTOME_EPH_EPHRIN_SIGNALING	ARHGEF7 VAV2 ITSN1	6.27e-04	92	26	3	M27201
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	ARHGEF7 VAV2 ITSN1	7.32e-04	97	26	3	M9400
Pathway	BIOCARTA_PTDINS_PATHWAY	PFKP VAV2	8.08e-04	23	26	2	M8809
Pathway	WP_INTEGRINMEDIATED_CELL_ADHESION	ARHGEF7 VAV2 CAPN10	8.47e-04	102	26	3	M39577
Pathway	REACTOME_CARGO_RECOGNITION_FOR_CLATHRIN_MEDIATED_ENDOCYTOSIS	ITSN1 ITSN2 SH3KBP1	8.47e-04	102	26	3	MM15498
Pathway	WP_INTEGRINMEDIATED_CELL_ADHESION	ARHGEF7 VAV2 CAPN10	8.47e-04	102	26	3	MM15830
Pathway	REACTOME_CARGO_RECOGNITION_FOR_CLATHRIN_MEDIATED_ENDOCYTOSIS	ITSN1 ITSN2 SH3KBP1	9.22e-04	105	26	3	M27752
Pathway	REACTOME_RHO_GTPASE_CYCLE	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	1.10e-03	439	26	5	MM15595
Pathway	REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS	IGHV3-43 IGHV3-20 VAV2	1.17e-03	114	26	3	MM14814
Pathway	REACTOME_RHO_GTPASE_CYCLE	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	1.22e-03	450	26	5	M27078
Pathway	REACTOME_NERVOUS_SYSTEM_DEVELOPMENT	ARHGEF7 VAV2 ITSN1 SH3KBP1	1.25e-03	261	26	4	MM15676
Pathway	REACTOME_EGFR_DOWNREGULATION	ARHGEF7 SH3KBP1	1.47e-03	31	26	2	MM14705
Pathway	REACTOME_EGFR_DOWNREGULATION	ARHGEF7 SH3KBP1	1.47e-03	31	26	2	M16597
Pathway	REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR	IGHV3-43 IGHV3-20 SH3KBP1	1.74e-03	131	26	3	MM15717
Pathway	REACTOME_CD22_MEDIATED_BCR_REGULATION	IGHV3-43 IGHV3-20	1.87e-03	35	26	2	MM17219
Pathway	REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS	ITSN1 ITSN2 SH3KBP1	2.20e-03	142	26	3	MM15499
Pathway	PID_RAC1_REG_PATHWAY	ARHGEF7 VAV2	2.21e-03	38	26	2	M241
Pathway	REACTOME_CLASSICAL_ANTIBODY_MEDIATED_COMPLEMENT_ACTIVATION	IGHV3-43 IGHV3-20	2.32e-03	39	26	2	MM17212
Pathway	REACTOME_RHOU_GTPASE_CYCLE	ARHGEF7 ITSN2	2.32e-03	39	26	2	MM15607
Pathway	REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS	ITSN1 ITSN2 SH3KBP1	2.33e-03	145	26	3	M27753
Pathway	REACTOME_RHOU_GTPASE_CYCLE	ARHGEF7 ITSN2	2.44e-03	40	26	2	M41816
Pathway	REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES	KL ARHGEF7 VAV2 DNMT1 SH3KBP1	2.56e-03	532	26	5	M27870
Pathway	REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING	IGHV3-43 IGHV3-20 VAV2	2.57e-03	150	26	3	MM14889
Pathway	REACTOME_CDC42_GTPASE_CYCLE	ARHGEF7 VAV2 ITSN1	2.82e-03	155	26	3	M41808
Pathway	REACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION	IGHV3-43 IGHV3-20	3.08e-03	45	26	2	MM14912
Pathway	REACTOME_FCGR_ACTIVATION	IGHV3-43 IGHV3-20	3.50e-03	48	26	2	MM17214
Pathway	REACTOME_NERVOUS_SYSTEM_DEVELOPMENT	ARHGEF7 VAV2 PRX ITSN1 SH3KBP1	3.58e-03	575	26	5	M29853
Pathway	REACTOME_SIGNALING_BY_EGFR	ARHGEF7 SH3KBP1	3.65e-03	49	26	2	MM14695
Pathway	REACTOME_RAC1_GTPASE_CYCLE	ALS2 ARHGEF7 VAV2	3.96e-03	175	26	3	MM15599
Pathway	REACTOME_SIGNALING_BY_EGFR	ARHGEF7 SH3KBP1	4.25e-03	53	26	2	M27039
Pathway	REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT	IGHV3-43 IGHV3-20	4.41e-03	54	26	2	MM14655
Pathway	REACTOME_RAC1_GTPASE_CYCLE	ALS2 ARHGEF7 VAV2	4.56e-03	184	26	3	M41809
Pathway	REACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS	IGHV3-43 IGHV3-20	4.74e-03	56	26	2	MM14815
Pathway	REACTOME_RHOQ_GTPASE_CYCLE	ARHGEF7 ITSN1	5.07e-03	58	26	2	MM15602
Pathway	REACTOME_RHOQ_GTPASE_CYCLE	ARHGEF7 ITSN1	5.25e-03	59	26	2	M41812
Pathway	REACTOME_MEMBRANE_TRAFFICKING	ALS2 F5 ITSN1 ITSN2 SH3KBP1	5.28e-03	630	26	5	M11480
Pathway	REACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS	IGHV3-43 IGHV3-20	5.42e-03	60	26	2	MM14872
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	5.99e-03	649	26	5	MM15690
Pubmed	Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus.	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9	1.12e-09	39	42	5	8490662
Pubmed	The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus.	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9 IGHV1-58	1.32e-09	91	42	6	9841928
Pubmed	Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.	ITSN1 CD2AP ITSN2 SH3KBP1	6.45e-07	56	42	4	22745667
Pubmed	CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes.	CD2AP SH3KBP1	1.42e-06	2	42	2	27531950
Pubmed	Intersectin deficiency impairs cortico-striatal neurotransmission and causes obsessive-compulsive behaviors in mice.	ITSN1 ITSN2	1.42e-06	2	42	2	37603735
Pubmed	Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain.	ITSN1 ITSN2	1.42e-06	2	42	2	31031201
Pubmed	Intersectin associates with synapsin and regulates its nanoscale localization and function.	ITSN1 ITSN2	1.42e-06	2	42	2	29078407
Pubmed	Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.	ITSN1 ITSN2	1.42e-06	2	42	2	23936226
Pubmed	Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition.	ITSN1 ITSN2	1.42e-06	2	42	2	23447614
Pubmed	CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes.	CD2AP SH3KBP1	1.42e-06	2	42	2	17213204
Pubmed	The human intersectin genes and their spliced variants are differentially expressed.	ITSN1 ITSN2	1.42e-06	2	42	2	11690630
Pubmed	Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation.	ITSN1 SH3KBP1	1.42e-06	2	42	2	19166927
Pubmed	Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration.	ARHGEF7 VAV2	1.42e-06	2	42	2	23615439
Pubmed	Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.	ARHGEF7 VAV2 ITSN1	3.70e-06	25	42	3	23873930
Pubmed	Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain.	ITSN1 ITSN2	4.27e-06	3	42	2	31718706
Pubmed	Inhibition of T cell activation and function by the adaptor protein CIN85.	CD2AP SH3KBP1	4.27e-06	3	42	2	30723173
Pubmed	The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2.	CD2AP SH3KBP1	4.27e-06	3	42	2	31142511
Pubmed	Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis.	ITSN1 ITSN2	4.27e-06	3	42	2	10922467
Pubmed	Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications.	CD2AP SH3KBP1	4.27e-06	3	42	2	24039852
Pubmed	CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP.	CD2AP SH3KBP1	4.27e-06	3	42	2	16895919
Pubmed	Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.	ARHGEF7 VAV2 ITSN1	5.25e-06	28	42	3	18067320
Pubmed	Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.	VAV2 ITSN1 CD2AP ITSN2	8.34e-06	106	42	4	18654987
Pubmed	Identification of CMS as a cytosolic adaptor of the human pTalpha chain involved in pre-TCR function.	CD2AP SH3KBP1	8.53e-06	4	42	2	17823309
Pubmed	Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85.	CD2AP SH3KBP1	8.53e-06	4	42	2	12690097
Pubmed	Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin.	ITSN1 ITSN2	8.53e-06	4	42	2	28161632
Pubmed	Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation.	CD2AP SH3KBP1	8.53e-06	4	42	2	17606992
Pubmed	Multimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*.	CD2AP SH3KBP1	8.53e-06	4	42	2	23663663
Pubmed	Cbl promotes clustering of endocytic adaptor proteins.	ARHGEF7 SH3KBP1	8.53e-06	4	42	2	16228008
Pubmed	The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15.	ITSN1 ITSN2	8.53e-06	4	42	2	10064583
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	MRPL28 ALS2 ARHGEF7 VAV2 ITSN1 CD2AP ITSN2 SH3KBP1	1.20e-05	916	42	8	32203420
Pubmed	Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain.	CD2AP SH3KBP1	1.42e-05	5	42	2	17020880
Pubmed	CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities.	CD2AP SH3KBP1	1.42e-05	5	42	2	12618476
Pubmed	Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation.	CD2AP SH3KBP1	1.42e-05	5	42	2	23279575
Pubmed	Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo.	SPIN1 DNMT1	1.42e-05	5	42	2	18599511
Pubmed	CD2AP regulates SUMOylation of CIN85 in podocytes.	CD2AP SH3KBP1	1.42e-05	5	42	2	22203040
Pubmed	CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes.	CD2AP SH3KBP1	1.42e-05	5	42	2	20457601
Pubmed	Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide.	CD2AP SH3KBP1	1.42e-05	5	42	2	24167568
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	NEDD9 ARHGEF7 ITSN2 SH3KBP1	2.04e-05	133	42	4	15144186
Pubmed	Potent rescue of human immunodeficiency virus type 1 late domain mutants by ALIX/AIP1 depends on its CHMP4 binding site.	CD2AP SH3KBP1	2.13e-05	6	42	2	17428861
Pubmed	Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.	ARHGEF7 VAV2	2.13e-05	6	42	2	16356860
Pubmed	Multiple Src Homology 3 Binding to the Ubiquitin Ligase Itch Conserved Proline-Rich Region.	ARHGEF7 ITSN1	2.13e-05	6	42	2	26613292
Pubmed	E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis.	CD2AP SH3KBP1	2.13e-05	6	42	2	33627783
Pubmed	Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications.	CD2AP SH3KBP1	2.98e-05	7	42	2	20654576
Pubmed	EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?	ITSN1 ITSN2	2.98e-05	7	42	2	10373452
Pubmed	Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.	ITSN1 SH3KBP1	3.97e-05	8	42	2	15719014
Pubmed	Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix.	ARHGEF7 SH3KBP1	3.97e-05	8	42	2	16407834
Pubmed	Protein interaction screening by quantitative immunoprecipitation combined with knockdown (QUICK).	CD2AP SH3KBP1	5.10e-05	9	42	2	17072306
Pubmed	Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release.	CD2AP SH3KBP1	5.10e-05	9	42	2	18641129
Pubmed	The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.	CD2AP SH3KBP1	6.37e-05	10	42	2	17314030
Pubmed	FCHo proteins are nucleators of clathrin-mediated endocytosis.	ITSN1 ITSN2	1.10e-04	13	42	2	20448150
Pubmed	IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes.	IGHV3-43 IGHV3-20 IGHV1-58	1.13e-04	77	42	3	15608191
Pubmed	The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.	NEDD9 CD2AP ITSN2	1.31e-04	81	42	3	20697350
Pubmed	Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins.	ITSN1 ITSN2	1.48e-04	15	42	2	9630982
Pubmed	1.3 A X-ray structure of an antibody Fv fragment used for induced membrane-protein crystallization.	IGHV3-43 IGHV3-20	1.48e-04	15	42	2	12657787
Pubmed	Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.	FBXW8 MIB2 FBXO17	1.51e-04	85	42	3	19028597
Pubmed	A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.	CD2AP SH3KBP1	1.91e-04	17	42	2	16678097
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	NEDD9 TNRC6B	2.15e-04	18	42	2	25363768
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	ARHGEF7 ITSN2	2.15e-04	18	42	2	12799088
Pubmed	Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.	VAV2 ITSN1	2.15e-04	18	42	2	27984743
Pubmed	Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.	CD2AP SH3KBP1	3.24e-04	22	42	2	30089695
Pubmed	Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.	IGHV3-43 IGHV3-20	3.24e-04	22	42	2	2499654
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	ITSN1 ITSN2 SH3KBP1	3.32e-04	111	42	3	22558309
Pubmed	The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.	CD2AP SH3KBP1	3.86e-04	24	42	2	21822214
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	ITSN1 CD2AP SH3KBP1	4.17e-04	120	42	3	31413325
Pubmed	Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.	CD2AP SH3KBP1	4.20e-04	25	42	2	12029088
Pubmed	Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.	VAV2 ITSN1	6.47e-04	31	42	2	25838543
Pubmed	Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice.	ITSN1 ITSN2	6.47e-04	31	42	2	19666558
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	KL ARHGEF7 ITSN1 SH3KBP1	8.08e-04	347	42	4	17114649
Pubmed	Mutation of ARHGAP9 in patients with coronary spastic angina.	VAV2 ITSN2	9.74e-04	38	42	2	19911011
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	VAV2 ITSN1	9.74e-04	38	42	2	11756498
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TAOK2 TNRC6B ARHGEF7 ITSN1 DNMT1 SH3KBP1	9.94e-04	963	42	6	28671696
Pubmed	Roles of tau protein in health and disease.	TAOK2 LGMN	1.08e-03	40	42	2	28386764
Pubmed	Proteomic identification of brain proteins that interact with dynein light chain LC8.	PFKP DNMT1	1.19e-03	42	42	2	14760703
Pubmed	A family of mammalian F-box proteins.	FBXW8 FBXO17	1.19e-03	42	42	2	10531037
Interaction	CBLB interactions	ARHGEF7 VAV2 ITSN1 CD2AP ITSN2 SH3KBP1	3.57e-08	115	34	6	int:CBLB
Interaction	ZYX interactions	NEDD9 TNRC6B ALS2 ARHGEF7 ITSN1 CD2AP	1.65e-05	329	34	6	int:ZYX
Interaction	PRRG4 interactions	ARHGEF7 VAV2 ITSN1	3.85e-05	39	34	3	int:PRRG4
Interaction	SOS1 interactions	ITSN1 CD2AP ITSN2 SH3KBP1	4.37e-05	117	34	4	int:SOS1
Interaction	SYNJ2 interactions	ITSN1 ITSN2 SH3KBP1	5.17e-05	43	34	3	int:SYNJ2
Interaction	TNRC6C interactions	TNRC6B MIB2 ITSN1 ITSN2	8.32e-05	138	34	4	int:TNRC6C
Interaction	ITSN2 interactions	TNRC6B ITSN1 ITSN2 SH3KBP1	1.06e-04	147	34	4	int:ITSN2
Interaction	SOS2 interactions	ITSN1 CD2AP ITSN2	1.34e-04	59	34	3	int:SOS2
Interaction	GAREM2 interactions	ITSN1 ITSN2	1.51e-04	11	34	2	int:GAREM2
Interaction	SH3KBP1 interactions	ITSN1 CD2AP ITSN2 DNMT1 SH3KBP1	1.73e-04	315	34	5	int:SH3KBP1
Interaction	CBL interactions	ARHGEF7 VAV2 ITSN1 CD2AP ITSN2 SH3KBP1	2.00e-04	516	34	6	int:CBL
Cytoband	14q32.33	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9 IGHV1-58	5.46e-08	228	41	6	14q32.33
Cytoband	Ensembl 112 genes in cytogenetic band chr14q32	LGMN IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV1-58	1.07e-05	566	41	6	chr14q32
GeneFamily	Immunoglobulin heavy locus at 14q32.33	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9 IGHV3-43D IGHV1-58	1.46e-08	187	29	7	349
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ALS2 ARHGEF7 VAV2 ITSN1 ITSN2	6.16e-08	66	29	5	722
GeneFamily	Proteases, serine	PRSS42P TPSG1 TMPRSS7	1.38e-04	63	29	3	738
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ITSN1 ITSN2	1.51e-03	36	29	2	823
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF7 VAV2 ITSN1	4.28e-03	206	29	3	682
GeneFamily	SH2 domain containing	SH2D4B VAV2	1.14e-02	101	29	2	741
Coexpression	HALLMARK_MITOTIC_SPINDLE	TAOK2 NEDD9 ALS2 ARHGEF7 ITSN1 CD2AP	4.00e-07	199	38	6	M5893
Coexpression	BOGNI_TREATMENT_RELATED_MYELOID_LEUKEMIA_DN	DDR1 MRPL28 CD2AP	1.49e-05	33	38	3	M8981
ToppCell	healthy_donor-Lymphocytic-Plasma_cell-IgG_Plasmablast\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IGHV3-43 IGHV3-35 IGHV3-20 IGHV3-16 IGHV3-9	2.80e-07	152	41	5	a2ba2d95ac9010e1a62db34dcad10d004f8a90cc
Disease	nephrotic syndrome (implicated_via_orthology)	CD2AP ITSN2 SH3KBP1	3.91e-06	24	38	3	DOID:1184 (implicated_via_orthology)
Disease	tauopathy (implicated_via_orthology)	CD2AP SH3KBP1	7.22e-05	10	38	2	DOID:680 (implicated_via_orthology)
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	KL DNMT1 CAPN10	8.99e-04	147	38	3	DOID:9352 (biomarker_via_orthology)
Disease	Colonic Neoplasms	F5 DNMT1 SH3KBP1	9.91e-04	152	38	3	C0009375
Disease	Malignant tumor of colon	F5 DNMT1 SH3KBP1	1.13e-03	159	38	3	C0007102
Disease	pneumonia	NEDD9 F5	1.68e-03	47	38	2	EFO_0003106

Protein segments in the cluster

Peptide	Gene	Start	Entry
TVIEQNTGGLEGWWL	NEDD9	31	Q14511
INEWWITGFDGGEKA	DNMT1	461	P26358
TEVWTWGKGKEGQLG	ALS2	526	Q96Q42
GWKDRWGQEVISGNE	DDR1	131	Q08345
QGLWREGGEGWSQVD	CAPN10	271	Q9HC96
VEEGGWWEGTLNGRT	ARHGEF7	216	Q14155
KETGEAGWWRGELNG	CD2AP	301	Q9Y5K6
VGGWNVAIWKEGVMT	DNAI3	691	Q8IWG1
FIIGTGWEEAVQGWG	C16orf46	61	Q6P387
TQKDGEWWTGSIGDR	ITSN2	1011	Q9NZM3
GQRLEWIGWIVVGSG	IGHV1-58	61	A0A0C4DH39
GKGLEWVSLISWDGG	IGHV3-43D	61	P0DP04
GKGLEWVSGISWNSG	IGHV3-9	61	P01782
EWLGGLKGRSGVWES	JPH4	86	Q96JJ6
WKIVSGGEEGLVSVW	FBXW8	486	Q8N3Y1
GQIKEIGWTDVGGWT	PFKP	456	Q01813
GKGLEWVSGINWNGG	IGHV3-20	61	A0A0C4DH32
AGGWGKWVRLNVGGT	KCTD17	26	Q8N5Z5
GKGLEWVSLISWDGG	IGHV3-43	61	A0A0B4J1X8
GWEVEHGGNGWAIEK	FBXO17	121	Q96EF6
GDWWTGTVGDKAGVF	ITSN1	1036	Q15811
TEGGWQQHGKGASIW	KL	76	Q9UEF7
GKGLEWVSGVSWNGS	IGHV3-16	61	A0A0C4DH30
GKGLEWVSGVSWNGS	IGHV3-35	61	A0A0C4DH35
VRGVDWKWGQQDGGE	MIB2	16	Q96AX9
WKWGQQDGGEGGVGT	MIB2	21	Q96AX9
NGAWVQAGTVSWGEG	TPSG1	231	Q9NRR2
VAEGGGLLIGGQAWW	TCAF2	351	A6NFQ2
LVVLGTSWVGWGSQG	F5	11	P12259
VEEGWWEGVLNGKTG	SH3KBP1	131	Q96B97
SVQWWMGGVPVGVDG	SIGLECL1	36	Q8N7X8
IVGQEEAGTWSLWGK	TAOK2	861	Q9UL54
LWAGQAKGILGGWGI	MSMP	6	Q1L6U9
DGKWILTGIVSWGHG	TMPRSS7	801	Q7RTY8
GWKEGNGPVTQWKGT	SPIN1	61	Q9Y657
GVAELEGKGWGWDGR	PRX	1041	Q9BXM0
NDTWVQVGIVSWGIG	PRSS42P	276	Q7Z5A4
QRGLWGGEGWILGQI	MRPL28	76	Q13084
EGGAIRESSGWVSWK	nan	691	Q3C1V9
LGADGEVWVWIMGEG	SH2D4B	71	Q5SQS7
GDQGWWKGETNGRIG	VAV2	851	P52735
IVSQVTEGHWKWGGV	WLS	451	Q5T9L3
TEGHWKWGGVTVQVN	WLS	456	Q5T9L3
GWSSGKNGWGEEVDQ	TNRC6B	741	Q9UPQ9
WGLGWRVEVGLEGAG	UNQ6493/PRO21345	46	Q6UXR8
GGKHWVVIVAGSNGW	LGMN	26	Q99538