Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionchromatin binding

GTF2F1 SAFB TOX3 H1-3 NAP1L3 SMARCC2 MACROH2A2 CHD3 CHD4 CHD6 CHD7 TOX2 MECP2 HMGN3 TOP2A TOP2B

1.60e-117395016GO:0003682
GeneOntologyMolecularFunctionhistone binding

SETD5 RBBP5 NAP1L3 PHF6 SMARCC2 DAXX CHD3 CHD4 CHD6 CHD7

9.21e-102655010GO:0042393
GeneOntologyMolecularFunctionchromatin DNA binding

TOX3 H1-3 SMARCC2 MACROH2A2 CHD4 TOX2 MECP2 HMGN3

8.06e-09167508GO:0031490
GeneOntologyMolecularFunctionnucleosomal DNA binding

H1-3 SMARCC2 MACROH2A2 CHD4 HMGN3

6.89e-0767505GO:0031492
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

CHD3 CHD4 CHD6 CHD7 TOP2A TOP2B

7.43e-07127506GO:0008094
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD3 CHD4 CHD6 CHD7

2.16e-0637504GO:0140658
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

NEIL1 CHD3 CHD4 CHD6 CHD7 TOP2A TOP2B

3.81e-06262507GO:0140097
GeneOntologyMolecularFunctionnucleosome binding

H1-3 SMARCC2 MACROH2A2 CHD4 HMGN3

4.57e-0698505GO:0031491
GeneOntologyMolecularFunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

TOP2A TOP2B

3.68e-054502GO:0003918
GeneOntologyMolecularFunctionATP-dependent activity

IQCA1L KIF3B CHD3 CHD4 CHD6 CHD7 TOP2A TOP2B

1.31e-04614508GO:0140657
GeneOntologyMolecularFunctionmolecular condensate scaffold activity

SURF6 DAXX MECP2

1.58e-0442503GO:0140693
GeneOntologyMolecularFunctionDNA topoisomerase activity

TOP2A TOP2B

1.70e-048502GO:0003916
GeneOntologyMolecularFunctiontranscription coregulator activity

SETD5 TOX3 SMARCC2 DAXX CHD4 TOX2 MECP2

4.71e-04562507GO:0003712
GeneOntologyMolecularFunctiontranscription factor binding

GTF2F1 DAXX CHD4 CHD6 TOX2 MECP2 HMGN3 ADD1

5.20e-04753508GO:0008134
GeneOntologyMolecularFunctionhelicase activity

CHD3 CHD4 CHD6 CHD7

6.55e-04158504GO:0004386
GeneOntologyMolecularFunctionATP hydrolysis activity

IQCA1L KIF3B CHD3 CHD4 CHD6 CHD7

7.83e-04441506GO:0016887
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

NEIL1 CHD3 CHD4 CHD6 CHD7 TOP2A TOP2B

1.06e-03645507GO:0140640
GeneOntologyMolecularFunctionpromoter-specific chromatin binding

GTF2F1 CHD7 MECP2

1.18e-0383503GO:1990841
GeneOntologyMolecularFunctionscaffold protein binding

TCOF1 PHF6 NLGN1

1.64e-0393503GO:0097110
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

TCOF1 SETD5 SURF6 TOX3 SMARCC2 DAXX CHD4 TOX2 MECP2

2.12e-031160509GO:0030674
GeneOntologyMolecularFunctiontranscription corepressor activity

SETD5 DAXX CHD4 MECP2

2.57e-03229504GO:0003714
GeneOntologyMolecularFunctiontranscription regulator inhibitor activity

SNIP1 DAXX

3.67e-0336502GO:0140416
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

DAXX CHD4 TOX2 HMGN3 ADD1

3.80e-03417505GO:0061629
GeneOntologyMolecularFunctionhistone deacetylase binding

PHF6 CHD4 MECP2

5.95e-03147503GO:0042826
GeneOntologyMolecularFunctionmolecular adaptor activity

TCOF1 SETD5 SURF6 TOX3 SMARCC2 DAXX CHD4 TOX2 MECP2

5.97e-031356509GO:0060090
GeneOntologyMolecularFunctiontranscription coactivator activity

TOX3 SMARCC2 DAXX TOX2

6.92e-03303504GO:0003713
GeneOntologyBiologicalProcesschromatin organization

SAFB ARID4A SETD5 RBBP5 H1-3 NAP1L3 SMARCC2 DAXX MACROH2A2 CHD3 CHD4 CHD6 CHD7 MECP2 HMGN3

1.78e-098965015GO:0006325
GeneOntologyBiologicalProcessprotein-DNA complex organization

SAFB ARID4A SETD5 RBBP5 H1-3 NAP1L3 SMARCC2 DAXX MACROH2A2 CHD3 CHD4 CHD6 CHD7 MECP2 HMGN3

7.79e-099995015GO:0071824
GeneOntologyBiologicalProcesschromatin remodeling

ARID4A SETD5 RBBP5 H1-3 NAP1L3 SMARCC2 DAXX MACROH2A2 CHD3 CHD4 CHD6 CHD7 MECP2

1.55e-087415013GO:0006338
GeneOntologyBiologicalProcesspositive regulation of single stranded viral RNA replication via double stranded DNA intermediate

TOP2A TOP2B

5.76e-062502GO:0045870
GeneOntologyBiologicalProcessnucleosome organization

H1-3 NAP1L3 SMARCC2 DAXX MACROH2A2

2.38e-05142505GO:0034728
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

ARID4A TRO H1-3 PHF6 SMARCC2 DAXX MACROH2A2 CHD3 CHD4 MECP2

1.83e-0410535010GO:0000122
GeneOntologyBiologicalProcessterminal button organization

CHD4 NLGN1

2.05e-049502GO:0072553
GeneOntologyBiologicalProcessnucleosome assembly

H1-3 NAP1L3 DAXX MACROH2A2

2.17e-04122504GO:0006334
GeneOntologyBiologicalProcessDNA topological change

TOP2A TOP2B

2.56e-0410502GO:0006265
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

GTF2F1 SAFB ARID4A TOX3 DAXX CHD6 CHD7 TOX2 MECP2 HMGN3 TOP2A

4.06e-0413905011GO:0045944
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

ARID4A SETD5 TRO H1-3 PHF6 SMARCC2 DAXX MACROH2A2 CHD3 CHD4 MECP2

4.29e-0413995011GO:0045892
GeneOntologyBiologicalProcessDNA damage response

GCNA PDS5B RBBP5 NEIL1 ZBTB40 SMARCC2 CHD4 TOP2A TOP2B

4.39e-04959509GO:0006974
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

ARID4A SETD5 TRO H1-3 PHF6 SMARCC2 DAXX MACROH2A2 CHD3 CHD4 MECP2

4.67e-0414135011GO:1902679
GeneOntologyCellularComponentchromatin

PDS5B ARID4A SETD5 H1-3 NAP1L3 NKX1-1 SMARCC2 DAXX MACROH2A2 CHD3 CHD4 CHD6 CHD7 MECP2 HMGN3 CREBL2 TOP2B

1.33e-0814804817GO:0000785
GeneOntologyCellularComponenthistone deacetylase complex

ARID4A SETD5 CHD3 CHD4

4.32e-0585484GO:0000118
GeneOntologyCellularComponentchromosomal region

PDS5B PHF6 SMARCC2 DAXX MACROH2A2 CHD4 TOP2A

4.62e-05421487GO:0098687
GeneOntologyCellularComponentchromosome, centromeric region

PDS5B PHF6 SMARCC2 DAXX TOP2A

4.17e-04276485GO:0000775
GeneOntologyCellularComponentNuRD complex

CHD3 CHD4

6.87e-0417482GO:0016581
GeneOntologyCellularComponentCHD-type complex

CHD3 CHD4

6.87e-0417482GO:0090545
GeneOntologyCellularComponentasymmetric, glutamatergic, excitatory synapse

CHD4 NLGN1

1.38e-0324482GO:0098985
GeneOntologyCellularComponentSWI/SNF superfamily-type complex

SMARCC2 CHD3 CHD4

1.40e-0396483GO:0070603
GeneOntologyCellularComponentheterochromatin

DAXX MECP2 TOP2B

1.62e-03101483GO:0000792
GeneOntologyCellularComponentnuclear chromosome

ARID4A SETD5 MACROH2A2 TOP2A

2.72e-03254484GO:0000228
GeneOntologyCellularComponentPML body

GCNA DAXX CHD3

2.97e-03125483GO:0016605
GeneOntologyCellularComponentATPase complex

SMARCC2 CHD3 CHD4

3.24e-03129483GO:1904949
GeneOntologyCellularComponentsex chromosome

DAXX MACROH2A2

4.59e-0344482GO:0000803
MousePhenoabsent nasal pit

TCOF1 CHD7

2.15e-053382MP:0030060
DomainCHROMO

ARID4A SMARCC2 CHD3 CHD4 CHD6 CHD7

2.49e-1033496SM00298
DomainChromo/shadow_dom

ARID4A SMARCC2 CHD3 CHD4 CHD6 CHD7

2.49e-1033496IPR000953
DomainChromodomain-like

ARID4A CHD3 CHD4 CHD6 CHD7

1.92e-0832495IPR016197
DomainChromo_domain

CHD3 CHD4 CHD6 CHD7

4.27e-0724494IPR023780
DomainChromo

CHD3 CHD4 CHD6 CHD7

5.99e-0726494PF00385
DomainCHROMO_2

CHD3 CHD4 CHD6 CHD7

8.17e-0728494PS50013
DomainCHROMO_1

CHD3 CHD4 CHD6 CHD7

8.17e-0728494PS00598
DomainSNF2_N

CHD3 CHD4 CHD6 CHD7

1.42e-0632494PF00176
DomainSNF2_N

CHD3 CHD4 CHD6 CHD7

1.42e-0632494IPR000330
DomainDNA/RNA_helicase_DEAH_CS

CHD3 CHD4 CHD6 CHD7

2.06e-0635494IPR002464
DomainDEAH_ATP_HELICASE

CHD3 CHD4 CHD6 CHD7

2.89e-0638494PS00690
DomainTOPRIM_C

TOP2A TOP2B

6.74e-062492IPR031660
DomainTOPRIM_C

TOP2A TOP2B

6.74e-062492PF16898
Domain-

TOP2A TOP2B

6.74e-0624923.90.199.10
DomainDNA_topoisoIV

TOP2A TOP2B

6.74e-062492PF00521
DomainTopo_IIA_A/C_ab

TOP2A TOP2B

6.74e-062492IPR013758
DomainTopo_IIA_A_a

TOP2A TOP2B

6.74e-062492IPR013757
DomainTopo_IIA_cen_dom

TOP2A TOP2B

6.74e-062492IPR013759
Domain-

TOP2A TOP2B

6.74e-0624923.40.50.670
DomainDTHCT

TOP2A TOP2B

6.74e-062492IPR012542
DomainTopoIIA_CS

TOP2A TOP2B

6.74e-062492IPR018522
DomainTOP4c

TOP2A TOP2B

6.74e-062492SM00434
DomainTOP2c

TOP2A TOP2B

6.74e-062492SM00433
DomainTopo_IIA-like_dom

TOP2A TOP2B

6.74e-062492IPR013760
DomainTopo_IIA_bsu_dom2

TOP2A TOP2B

6.74e-062492IPR013506
DomainDTHCT

TOP2A TOP2B

6.74e-062492PF08070
DomainDNA_gyraseB

TOP2A TOP2B

6.74e-062492PF00204
Domain-

TOP2A TOP2B

6.74e-0624921.10.268.10
DomainTopo_IIA_A/C

TOP2A TOP2B

6.74e-062492IPR002205
DomainTopo_IIA

TOP2A TOP2B

6.74e-062492IPR001241
DomainTOPOISOMERASE_II

TOP2A TOP2B

6.74e-062492PS00177
Domain-

TOP2A TOP2B

2.02e-0534923.30.1360.40
DomainCHDCT2

CHD3 CHD4

2.02e-053492PF08074
DomainCHDNT

CHD3 CHD4

2.02e-053492PF08073
DomainDUF1086

CHD3 CHD4

2.02e-053492IPR009462
DomainDUF1087

CHD3 CHD4

2.02e-053492IPR009463
DomainDUF1087

CHD3 CHD4

2.02e-053492PF06465
DomainDUF1086

CHD3 CHD4

2.02e-053492PF06461
DomainDUF1087

CHD3 CHD4

2.02e-053492SM01147
DomainDUF1086

CHD3 CHD4

2.02e-053492SM01146
DomainArg_repress_C-like

TOP2A TOP2B

2.02e-053492IPR024946
DomainCHD_N

CHD3 CHD4

2.02e-053492IPR012958
DomainCHD_C2

CHD3 CHD4

2.02e-053492IPR012957
DomainHMG_box_dom

TOX3 CHD3 CHD4 TOX2

2.52e-0565494IPR009071
DomainTOPRIM

TOP2A TOP2B

4.03e-054492PS50880
DomainToprim_domain

TOP2A TOP2B

4.03e-054492IPR006171
DomainToprim

TOP2A TOP2B

4.03e-054492PF01751
DomainPHD

PHF6 CHD3 CHD4 RAI1

8.66e-0589494SM00249
DomainZnf_PHD

PHF6 CHD3 CHD4 RAI1

9.45e-0591494IPR001965
DomainBRK

CHD6 CHD7

1.00e-046492SM00592
DomainBRK_domain

CHD6 CHD7

1.00e-046492IPR006576
DomainBRK

CHD6 CHD7

1.00e-046492PF07533
DomainZF_PHD_2

PHF6 CHD3 CHD4 RAI1

1.12e-0495494PS50016
DomainZF_PHD_1

PHF6 CHD3 CHD4 RAI1

1.16e-0496494PS01359
DomainHelicase_C

CHD3 CHD4 CHD6 CHD7

1.77e-04107494PF00271
DomainHELICc

CHD3 CHD4 CHD6 CHD7

1.77e-04107494SM00490
DomainHelicase_C

CHD3 CHD4 CHD6 CHD7

1.83e-04108494IPR001650
DomainHELICASE_CTER

CHD3 CHD4 CHD6 CHD7

1.90e-04109494PS51194
DomainHELICASE_ATP_BIND_1

CHD3 CHD4 CHD6 CHD7

1.90e-04109494PS51192
DomainDEXDc

CHD3 CHD4 CHD6 CHD7

1.90e-04109494SM00487
DomainHelicase_ATP-bd

CHD3 CHD4 CHD6 CHD7

1.97e-04110494IPR014001
DomainSANT

SMARCC2 CHD6 CHD7

3.05e-0450493SM00717
DomainSANT/Myb

SMARCC2 CHD6 CHD7

3.43e-0452493IPR001005
Domain-

TOX3 CHD3 TOX2

4.04e-04554931.10.30.10
DomainHATPase_c

TOP2A TOP2B

1.00e-0318492SM00387
DomainHATPase_c

TOP2A TOP2B

1.12e-0319492PF02518
Domain-

TOP2A TOP2B

1.24e-03204923.30.565.10
DomainHATPase_C

TOP2A TOP2B

1.37e-0321492IPR003594
Domain-

TOP2A TOP2B

1.37e-03214923.30.230.10
DomainEPHD

PHF6 RAI1

1.51e-0322492PS51805
DomainRibosomal_S5_D2-typ_fold_subgr

TOP2A TOP2B

1.51e-0322492IPR014721
DomainAT_hook

PDS5B MECP2

2.27e-0327492SM00384
DomainAT_hook_DNA-bd_motif

PDS5B MECP2

2.27e-0327492IPR017956
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

ARID4A RBBP5 SMARCC2 CHD3 CHD4

4.99e-05175335MM14941
PathwayREACTOME_SUMOYLATION

SAFB DAXX CHD3 TOP2A TOP2B

7.19e-05189335M27214
PathwayBIOCARTA_DNAFRAGMENT_PATHWAY

TOP2A TOP2B

2.36e-0410332M7239
PathwayREACTOME_HDACS_DEACETYLATE_HISTONES

ARID4A CHD3 CHD4

2.82e-0455333MM14932
PathwayBIOCARTA_DNAFRAGMENT_PATHWAY

TOP2A TOP2B

2.88e-0411332MM1349
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

ARID4A RBBP5 SMARCC2 CHD3 CHD4

3.93e-04272335M29619
PathwayREACTOME_SUMOYLATION

SAFB DAXX TOP2A TOP2B

6.22e-04169334MM14919
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

PDS5B ARID4A RBBP5 ZBTB40 SMARCC2 DAXX CHD3 CHD4 CHD6 CHD7 MECP2 TOP2A TOP2B RAI1 LRRC41

4.70e-15608501536089195
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

PDS5B SAFB TCOF1 ARID4A ZBTB40 SMARCC2 DAXX CHD3 CHD4 CHD7 MECP2 TOP2A TOP2B ADD1

2.91e-12774501415302935
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

PDS5B SETD5 H1-3 SMARCC2 DAXX MACROH2A2 CHD3 CHD4 MECP2 HMGN3 TOP2A TOP2B

1.06e-11533501230554943
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

PDS5B SAFB PDE6H ARID4A SURF6 PHF6 SMARCC2 CHD3 CHD4 CHD7 MECP2 TOP2A TOP2B RAI1

4.65e-11954501436373674
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

PDS5B SNIP1 IBTK H1-3 SMARCC2 CHD3 CHD6 CHD7 MECP2 TOP2A TOP2B

5.55e-11469501127634302
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

TCOF1 MACROH2A2 CHD3 CHD4 TOP2A TOP2B RAI1

1.46e-1010350732744500
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

SNIP1 SAFB TCOF1 ARID4A RBBP5 SURF6 CHD3 CHD4 CHD6 CHD7 MECP2 HMGN3 TOP2A TOP2B RAI1

2.21e-101294501530804502
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

PDS5B SAFB SETD5 TRO H1-3 SMARCC2 CHD3 CHD4 CHD6 MECP2 HMGN3 TOP2A TOP2B RAI1 CFAP46

9.81e-101442501535575683
Pubmed

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.

SAFB SURF6 PHF6 MACROH2A2 CHD3 CHD4 MECP2 TOP2A TOP2B

9.95e-1033050933301849
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

SNIP1 SAFB RBBP5 H1-3 MACROH2A2 CHD4 TOP2A TOP2B

2.72e-0925150831076518
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

PDS5B GTF2F1 SAFB ZBTB40 PHF6 SMARCC2 CHD3 CHD4 CHD7 MECP2 TOP2A TOP2B RAI1

3.66e-091103501334189442
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

PDS5B RBBP5 PHF6 SMARCC2 DAXX CHD3 CHD7 TOP2A RAI1

4.67e-0939450927248496
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

ARID4A RBBP5 TRO ZBTB40 SMARCC2 MACROH2A2 CHD4 MECP2 TOP2A TOP2B LRRC41

2.97e-08857501125609649
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

SNIP1 TCOF1 SETD5 SURF6 SMARCC2 MACROH2A2 CHD3 CHD4 MECP2 TOP2A RAI1 LRRC41

4.43e-081116501231753913
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

SAFB TCOF1 SURF6 CHD4 TOP2A TOP2B

7.30e-0814850632538781
Pubmed

Nucleolar proteome dynamics.

GTF2F1 SURF6 H1-3 PHF6 CHD3 CHD4 TOP2A TOP2B

1.43e-0741950815635413
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

PDS5B GTF2F1 SAFB RBBP5 PHF6 SMARCC2 CHD3 CHD4 HMGN3 TOP2A TOP2B

1.62e-071014501132416067
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

SAFB TCOF1 SMARCC2 CHD3 CHD4 TOP2A TOP2B RAI1 KRT80

1.82e-0760550928977666
Pubmed

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.

GTF2F1 SAFB TCOF1 SURF6 H1-3 CHD4 MECP2 TOP2A

2.11e-0744150831239290
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

PDS5B SNIP1 SAFB TCOF1 H1-3 PHF6 CHD4 CHD6 CHD7 TOP2A TOP2B ADD1

2.67e-071318501230463901
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

PDS5B SAFB TCOF1 SURF6 SMARCC2 MACROH2A2 CHD4 CHD6 CHD7 MECP2 TOP2B

3.09e-071082501138697112
Pubmed

Oct4 links multiple epigenetic pathways to the pluripotency network.

TCOF1 RBBP5 SMARCC2 CHD4 TOX2 TOP2B

4.71e-0720350622083510
Pubmed

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

SAFB SURF6 DAXX MACROH2A2 CHD4 MECP2 RAI1

6.65e-0734950725665578
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

IBTK SAFB TCOF1 SURF6 PHF6 CHD3 CHD4 TOP2A TOP2B ADD1

7.22e-07934501033916271
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

PDS5B IBTK SURF6 PHF6 MACROH2A2 CHD3 CHD4 TOP2A TOP2B

1.21e-0675950935915203
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

GTF2F1 COL27A1 H1-3 SMARCC2 CHD3 TOP2A

1.58e-0625050633536335
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

PDS5B SAFB TCOF1 SMARCC2 MACROH2A2 CHD3 CHD4 TOP2A TOP2B KRT80

1.65e-061024501024711643
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PDS5B KIF3B SETD5 TRO PHF6 CHD6 NLGN1

1.85e-0640750712693553
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

SNIP1 TCOF1 SURF6 MACROH2A2 CHD4 RAI1

1.94e-0625950630404004
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

GTF2F1 SAFB SMARCC2 MACROH2A2 CHD4 CHD7 TOP2A

1.97e-0641150735182466
Pubmed

DNA topoisomerase II is dispensable for oocyte meiotic resumption but is essential for meiotic chromosome condensation and separation in mice.

TOP2A TOP2B

2.03e-06250224048577
Pubmed

Association of immunophenotype with expression of topoisomerase II α and β in adult acute myeloid leukemia.

TOP2A TOP2B

2.03e-06250232218491
Pubmed

CHD chromatin remodelling enzymes and the DNA damage response.

CHD4 CHD6

2.03e-06250223954449
Pubmed

Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen.

CHD3 CHD4

2.03e-0625027560064
Pubmed

Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.

TOP2A TOP2B

2.03e-0625021309226
Pubmed

Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.

TOP2A TOP2B

2.03e-06250219222228
Pubmed

Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells.

TOP2A TOP2B

2.03e-0625022555055
Pubmed

Involvement of human topoisomerase II isoforms in HIV-1 reverse transcription.

TOP2A TOP2B

2.03e-06250223399433
Pubmed

Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2.

TOP2A TOP2B

2.03e-06250230169847
Pubmed

Characterization of cDNA encoding the mouse DNA topoisomerase II that can complement the budding yeast top2 mutation.

TOP2A TOP2B

2.03e-0625021331984
Pubmed

Enhanced processing of UVA-irradiated DNA by human topoisomerase II in living cells.

TOP2A TOP2B

2.03e-06250215044480
Pubmed

C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.

TOP2A TOP2B

2.03e-06250217526531
Pubmed

Doxorubicin-induced cardiotoxicity is maturation dependent due to the shift from topoisomerase IIα to IIβ in human stem cell derived cardiomyocytes.

TOP2A TOP2B

2.03e-06250231106979
Pubmed

A biochemical analysis of topoisomerase II alpha and beta kinase activity found in HIV-1 infected cells and virus.

TOP2A TOP2B

2.03e-06250216091284
Pubmed

The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.

TOP2A TOP2B

2.03e-0625029155056
Pubmed

Kinetic analysis of human topoisomerase IIalpha and beta DNA binding by surface plasmon resonance.

TOP2A TOP2B

2.03e-06250214596941
Pubmed

Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.

TOP2A TOP2B

2.03e-06250217361331
Pubmed

DNA topoisomerase II distribution in mouse preimplantation embryos.

TOP2A TOP2B

2.03e-06250211835579
Pubmed

Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication.

TOP2A TOP2B

2.03e-06250210095062
Pubmed

Functional compatibility between isoform alpha and beta of type II DNA topoisomerase.

TOP2A TOP2B

2.03e-06250214996935
Pubmed

Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes.

TOP2A TOP2B

2.03e-0625022556712
Pubmed

A study of the topoisomerase II activity in HIV-1 replication using the ferrocene derivatives as probes.

TOP2A TOP2B

2.03e-06250216712776
Pubmed

Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms.

TOP2A TOP2B

2.03e-0625028710863
Pubmed

Structural organization of the human TOP2A and TOP2B genes.

TOP2A TOP2B

2.03e-0625029795238
Pubmed

The distribution of DNA topoisomerase II isoforms in differentiated adult mouse tissues.

TOP2A TOP2B

2.03e-0625028241259
Pubmed

Mining topoisomerase isoforms in gastric cancer.

TOP2A TOP2B

2.03e-06250232535049
Pubmed

Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon.

TOP2A TOP2B

2.03e-06250226612825
Pubmed

Using a biochemical approach to identify the primary dimerization regions in human DNA topoisomerase IIalpha.

TOP2A TOP2B

2.03e-06250210473615
Pubmed

Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development.

TOP2A TOP2B

2.03e-0625021380833
Pubmed

CHD6 is a DNA-dependent ATPase and localizes at nuclear sites of mRNA synthesis.

CHD3 CHD6

2.03e-06250217027977
Pubmed

Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells.

TOP2A TOP2B

2.03e-06250211927602
Pubmed

Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells.

TOP2A TOP2B

2.03e-06250217182034
Pubmed

Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development.

CHD3 CHD4

2.03e-06250235568926
Pubmed

Cellular distribution of mammalian DNA topoisomerase II is determined by its catalytically dispensable C-terminal domain.

TOP2A TOP2B

2.03e-0625029224616
Pubmed

DNA damage response during chromatin remodeling in elongating spermatids of mice.

TOP2A TOP2B

2.03e-06250218032420
Pubmed

Discrete localization of different DNA topoisomerases in HeLa and K562 cell nuclei and subnuclear fractions.

TOP2A TOP2B

2.03e-0625028299728
Pubmed

Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.

TOP2A TOP2B

2.03e-06250222111588
Pubmed

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

TOP2A TOP2B

2.03e-06250217578914
Pubmed

The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation.

CHD3 CHD4

2.03e-0625027575689
Pubmed

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons.

TOP2A TOP2B

2.03e-06250228700616
Pubmed

Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen.

CHD3 CHD4

2.03e-0625028843877
Pubmed

Predictors and mechanisms of epilepsy occurrence in cerebral gliomas: What to look for in clinicopathology.

TOP2A TOP2B

2.03e-06250228087392
Pubmed

Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint.

TOP2A TOP2B

2.03e-06250228472494
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

RBBP5 SMARCC2 CHD3 CHD4 CHD7 RAI1

2.37e-0626850633640491
Pubmed

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

TCOF1 SMARCC2 CHD3 CHD4 TOP2A TOP2B

2.52e-0627150632433965
Pubmed

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.

PDS5B ARID4A CNST NEIL1 SURF6 PHF6 RAI1

2.70e-0643150733660365
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

SAFB TCOF1 RBBP5 SURF6 SMARCC2 CHD3 CHD4 TOP2A TOP2B

2.96e-0684750935850772
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

TCOF1 RBBP5 SMARCC2 DAXX CHD4 TOP2A TOP2B

3.09e-0644050734244565
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

SMARCC2 CHD3 CHD4 CHD6 CHD7

3.16e-0615750530186101
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

SURF6 CHD3 CHD7 MECP2 TOP2A TOP2B

3.24e-0628350630585729
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

NAP1L3 PHF6 SMARCC2 MACROH2A2 CHD6 CHD7 RAI1 LRRC41

3.34e-0663850831182584
Pubmed

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding.

TCOF1 CHD4 MECP2 TOP2A

3.62e-067250431248990
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

SAFB SURF6 SMARCC2 CHD4 TOP2A

3.80e-0616350522113938
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

PDS5B TCOF1 SURF6 H1-3 SMARCC2 CHD4 CHD7 RAI1

3.96e-0665350822586326
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

PDS5B SAFB H1-3 PHF6 MACROH2A2 TOP2A TOP2B KRT80

4.29e-0666050832780723
Pubmed

Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.

GTF2F1 SAFB SMARCC2 CHD4 TOP2B

4.66e-0617050516159877
Pubmed

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

SMARCC2 MACROH2A2 CHD7 RAI1

4.98e-067850428611094
Pubmed

DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.

TOP2A TOP2B

6.07e-06350223466610
Pubmed

Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1.

TOP2A TOP2B

6.07e-06350217567603
Pubmed

Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis.

TOP2A TOP2B

6.07e-06350211136718
Pubmed

Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation.

DAXX MECP2

6.07e-06350222500635
Pubmed

Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53.

TOP2A TOP2B

6.07e-06350210666337
Pubmed

The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development.

CHD3 CHD4

6.07e-06350232658897
Pubmed

Nucleophagy contributes to genome stability through degradation of type II topoisomerases A and B and nucleolar components.

TOP2A TOP2B

6.07e-06350236633090
Pubmed

Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage.

TOP2A TOP2B

6.07e-06350216611985
Pubmed

The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy.

SETD5 CHD4

6.07e-06350231474762
Pubmed

The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.

CHD6 CHD7

6.07e-06350228533432
Pubmed

Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).

TOP2A TOP2B

6.07e-06350224808172
Pubmed

Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta.

TOP2A TOP2B

6.07e-06350212821127
Pubmed

Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities.

TOP2A TOP2B

6.07e-0635029049244
InteractionH2BC8 interactions

PDS5B GTF2F1 ARID4A RBBP5 PHF6 SMARCC2 MACROH2A2 CHD3 CHD4 CHD6 CHD7 MECP2 TOP2A TOP2B RAI1 LRRC41

3.23e-135765016int:H2BC8
InteractionBRD3 interactions

PDS5B SNIP1 SETD5 SURF6 H1-3 SMARCC2 DAXX MACROH2A2 CHD4 MECP2 HMGN3 TOP2A TOP2B RAI1

9.85e-124945014int:BRD3
InteractionH3C3 interactions

PDS5B ARID4A RBBP5 SMARCC2 DAXX CHD3 CHD4 CHD6 CHD7 MECP2 TOP2A TOP2B RAI1 LRRC41

1.01e-114955014int:H3C3
InteractionH2BC21 interactions

PDS5B ARID4A RBBP5 H1-3 SMARCC2 DAXX MACROH2A2 CHD4 CHD7 MECP2 HMGN3 TOP2A TOP2B RAI1 CFAP46

7.48e-116965015int:H2BC21
InteractionZNF330 interactions

PDS5B GTF2F1 SURF6 PHF6 SMARCC2 CHD3 CHD7 MECP2 TOP2A TOP2B RAI1 LRRC41

6.76e-104465012int:ZNF330
InteractionH3-3A interactions

PDS5B RBBP5 H1-3 ZBTB40 SMARCC2 DAXX CHD3 CHD4 CHD7 MECP2 TOP2A TOP2B RAI1 LRRC41

2.30e-097495014int:H3-3A
InteractionGLYR1 interactions

NEIL1 SURF6 H1-3 MACROH2A2 CHD3 CHD4 MECP2 TOP2A TOP2B

6.55e-09239509int:GLYR1
InteractionCOIL interactions

PDS5B GTF2F1 PHF6 DAXX CHD3 CHD4 CHD6 CHD7 MECP2 TOP2A TOP2B LRRC41

7.44e-095525012int:COIL
InteractionSRRM1 interactions

SNIP1 GTF2F1 SAFB NEIL1 SMARCC2 CHD3 CHD4 MECP2 TOP2A TOP2B

1.15e-083485010int:SRRM1
InteractionPOU5F1 interactions

IBTK TCOF1 RBBP5 H1-3 SMARCC2 CHD3 CHD4 CHD7 TOX2 TOP2A TOP2B LRRC41

1.39e-085845012int:POU5F1
InteractionPYHIN1 interactions

SAFB TCOF1 RBBP5 DAXX MACROH2A2 CHD4 MECP2 TOP2A TOP2B RAI1

1.51e-083585010int:PYHIN1
InteractionARID1A interactions

SNIP1 RBBP5 SMARCC2 CHD3 CHD4 CHD7 MECP2 TOP2A TOP2B

2.28e-08276509int:ARID1A
InteractionCENPA interactions

PDS5B GTF2F1 CHD3 CHD6 CHD7 MECP2 TOP2A TOP2B RAI1 LRRC41

2.46e-083775010int:CENPA
InteractionFBL interactions

TCOF1 NEIL1 TRO SURF6 NAP1L3 PHF6 CHD3 CHD4 MECP2 TOP2A TOP2B LRRC41

3.75e-086395012int:FBL
InteractionCHD4 interactions

SNIP1 SAFB TCOF1 PHF6 SMARCC2 DAXX MACROH2A2 CHD3 CHD4 MECP2 TOP2A TOP2B RAI1 KRT80

3.98e-089385014int:CHD4
InteractionH2BC3 interactions

PDS5B RBBP5 PHF6 SMARCC2 DAXX CHD3 CHD4 CHD7 HMGN3 RAI1

4.94e-084065010int:H2BC3
InteractionPARP1 interactions

PDS5B GTF2F1 H1-3 PHF6 SMARCC2 DAXX MACROH2A2 CHD3 CHD4 CHD6 CHD7 MECP2 TOP2A TOP2B RAI1 KRT80

5.91e-0813165016int:PARP1
InteractionSSRP1 interactions

SNIP1 SAFB SETD5 RBBP5 DAXX MACROH2A2 CHD3 CHD4 MECP2 TOP2A TOP2B RAI1

8.02e-086855012int:SSRP1
InteractionH2BC12 interactions

PDS5B TRO H1-3 MACROH2A2 CHD3 CHD4 HMGN3 TOP2A TOP2B

8.55e-08322509int:H2BC12
InteractionSMC5 interactions

PDS5B SAFB PDE6H ARID4A SURF6 PHF6 SMARCC2 CHD3 CHD4 CHD7 MECP2 TOP2A TOP2B RAI1

8.81e-0810005014int:SMC5
InteractionRFC1 interactions

IBTK NEIL1 SURF6 DAXX MACROH2A2 CHD3 CHD4 TOP2A

9.36e-08231508int:RFC1
InteractionTOP1 interactions

GTF2F1 SAFB TCOF1 RBBP5 SMARCC2 MACROH2A2 CHD3 CHD4 MECP2 TOP2A TOP2B RAI1

9.54e-086965012int:TOP1
InteractionNOP56 interactions

IBTK GTF2F1 TCOF1 NEIL1 SURF6 H1-3 CHD3 CHD4 MECP2 TOP2A TOP2B

1.16e-075705011int:NOP56
InteractionH2BC9 interactions

PDS5B SNIP1 TRO H1-3 SMARCC2 CHD3 CHD4 HMGN3 TOP2A RAI1

1.19e-074465010int:H2BC9
InteractionRBBP4 interactions

SAFB ARID4A RBBP5 PHF6 SMARCC2 CHD3 CHD4 CHD7 MECP2 TOP2A RAI1

1.22e-075735011int:RBBP4
InteractionZBTB2 interactions

SAFB SURF6 PHF6 DAXX MACROH2A2 CHD3 CHD4 MECP2 TOP2A TOP2B

1.29e-074505010int:ZBTB2
InteractionNOC3L interactions

SNIP1 TCOF1 NEIL1 SURF6 H1-3 MACROH2A2 CHD3 CHD4

1.43e-07244508int:NOC3L
InteractionSMARCC2 interactions

SNIP1 GTF2F1 RBBP5 SMARCC2 CHD3 CHD4 CHD7 MECP2 TOP2B

1.87e-07353509int:SMARCC2
InteractionH3C1 interactions

PDS5B GTF2F1 RBBP5 H1-3 SMARCC2 DAXX MACROH2A2 CHD3 CHD4 CHD7 MECP2 TOP2A TOP2B

1.99e-079015013int:H3C1
InteractionDDX23 interactions

PDS5B GTF2F1 SAFB TCOF1 SURF6 CHD3 CHD4 MECP2 TOP2A TOP2B

2.34e-074805010int:DDX23
InteractionREXO4 interactions

SNIP1 NEIL1 SURF6 H1-3 MACROH2A2 CHD3 CHD4 MECP2

2.39e-07261508int:REXO4
InteractionAPEX1 interactions

PDS5B GTF2F1 SAFB TCOF1 ARID4A NEIL1 SURF6 SMARCC2 DAXX CHD4 CHD7 MECP2 TOP2B RAI1 LRRC41

2.53e-0712715015int:APEX1
InteractionRBM28 interactions

SNIP1 NEIL1 SURF6 H1-3 DAXX MACROH2A2 CHD3 CHD4 MECP2

2.65e-07368509int:RBM28
InteractionPOLR1G interactions

PDS5B GTF2F1 TCOF1 SURF6 SMARCC2 CHD7 MECP2 TOP2A TOP2B RAI1

2.78e-074895010int:POLR1G
InteractionH2AZ1 interactions

RBBP5 PHF6 SMARCC2 MACROH2A2 CHD4 SLCO6A1 TOP2A TOP2B RAI1

2.84e-07371509int:H2AZ1
InteractionNUP43 interactions

PDS5B SAFB ARID4A RBBP5 SURF6 TOX3 CHD3 CHD6 MECP2 TOP2A TOP2B

2.91e-076255011int:NUP43
InteractionGNL2 interactions

SNIP1 GTF2F1 RBBP5 NEIL1 SURF6 H1-3 CHD3 CHD4 MECP2

3.96e-07386509int:GNL2
InteractionDKC1 interactions

TCOF1 RBBP5 NEIL1 H1-3 DAXX MACROH2A2 CHD3 CHD4 MECP2

4.60e-07393509int:DKC1
InteractionSMARCE1 interactions

SNIP1 RBBP5 SMARCC2 CHD3 CHD4 CHD7 MECP2 TOP2B

4.91e-07287508int:SMARCE1
InteractionHMGA1 interactions

RBBP5 H1-3 MACROH2A2 CHD4 MECP2 TOP2A TOP2B RAI1 CFAP46

7.85e-07419509int:HMGA1
InteractionH2BC13 interactions

PDS5B TCOF1 H1-3 DAXX CHD4 HMGN3 TOP2A

8.25e-07210507int:H2BC13
InteractionBRD2 interactions

SNIP1 SMARCC2 DAXX MACROH2A2 CHD3 CHD4 MECP2 TOP2A TOP2B

9.55e-07429509int:BRD2
InteractionHDAC2 interactions

ARID4A RBBP5 H1-3 SMARCC2 DAXX CHD3 CHD4 MECP2 TOP2A TOP2B RAI1 KRT80

9.75e-078655012int:HDAC2
InteractionNIFK interactions

GTF2F1 TCOF1 RBBP5 NEIL1 SURF6 CHD3 CHD4 MECP2 TOP2B

9.92e-07431509int:NIFK
InteractionKLHL20 interactions

PDS5B SAFB PHF6 MACROH2A2 MECP2 TOP2A TOP2B

9.96e-07216507int:KLHL20
InteractionBMS1 interactions

SNIP1 NEIL1 SURF6 H1-3 MACROH2A2 CHD4 MECP2

1.06e-06218507int:BMS1
InteractionNUCKS1 interactions

RBBP5 H1-3 MACROH2A2 MECP2 TOP2A TOP2B RAI1

1.13e-06220507int:NUCKS1
InteractionZC3H18 interactions

SNIP1 SAFB TCOF1 NEIL1 SURF6 H1-3 DAXX MACROH2A2 CHD3 CHD4 MECP2 TOP2A

1.13e-068775012int:ZC3H18
InteractionSUPT16H interactions

SNIP1 RBBP5 SMARCC2 DAXX MACROH2A2 CHD3 CHD4 MECP2 TOP2B

1.22e-06442509int:SUPT16H
InteractionKRI1 interactions

SAFB NEIL1 SURF6 H1-3 DAXX CHD3 CHD4

1.31e-06225507int:KRI1
InteractionNLE1 interactions

TCOF1 SURF6 MACROH2A2 CHD3 MECP2 TOP2A TOP2B

1.43e-06228507int:NLE1
InteractionPPAN-P2RY11 interactions

NEIL1 SURF6 H1-3 DAXX MACROH2A2 CHD4

1.47e-06144506int:PPAN-P2RY11
InteractionDDX18 interactions

TCOF1 RBBP5 NEIL1 SURF6 MACROH2A2 CHD3 CHD4 MECP2

1.53e-06334508int:DDX18
InteractionSMARCA4 interactions

SNIP1 GTF2F1 SMARCC2 CHD3 CHD4 CHD7 MECP2 TOP2A TOP2B

1.76e-06462509int:SMARCA4
InteractionCHD3 interactions

SAFB RBBP5 PHF6 SMARCC2 CHD3 CHD4 CHD6 TOP2A TOP2B RAI1 KRT80

1.91e-067575011int:CHD3
InteractionRPL23A interactions

SNIP1 GTF2F1 SAFB NEIL1 SURF6 DAXX CHD3 CHD4 MECP2 RAI1

1.95e-066065010int:RPL23A
InteractionSMARCA2 interactions

SNIP1 GTF2F1 RBBP5 SMARCC2 CHD3 CHD4 MECP2 TOP2B

1.99e-06346508int:SMARCA2
InteractionCSNK2A1 interactions

GTF2F1 SAFB TCOF1 RBBP5 NEIL1 SURF6 SMARCC2 DAXX CHD3 CHD4 MECP2 TOP2A

2.77e-069565012int:CSNK2A1
InteractionSMARCB1 interactions

SNIP1 GTF2F1 RBBP5 SMARCC2 CHD3 CHD4 MECP2 TOP2B

2.90e-06364508int:SMARCB1
InteractionHNRNPC interactions

SNIP1 SAFB TCOF1 PHF6 SMARCC2 CHD3 CHD4 PKDREJ MECP2 TOP2A

2.92e-066345010int:HNRNPC
InteractionPUM3 interactions

SNIP1 NEIL1 SURF6 H1-3 MACROH2A2 CHD3 CHD4

2.93e-06254507int:PUM3
InteractionH2AC4 interactions

PDS5B RBBP5 H1-3 PHF6 DAXX CHD3 CHD4 TOP2A RAI1

3.70e-06506509int:H2AC4
InteractionRBBP7 interactions

SAFB TCOF1 ARID4A RBBP5 PHF6 SMARCC2 DAXX CHD3 CHD4

3.76e-06507509int:RBBP7
InteractionDCAF4 interactions

IBTK TCOF1 RBBP5 TRO SURF6 CHD6 TOP2A TOP2B

3.84e-06378508int:DCAF4
InteractionTOP2B interactions

SMARCC2 DAXX CHD3 CHD4 MECP2 TOP2A TOP2B

3.97e-06266507int:TOP2B
InteractionCPSF2 interactions

SNIP1 RBBP5 SMARCC2 CHD3 CHD4 MECP2

4.26e-06173506int:CPSF2
InteractionSMARCC1 interactions

GTF2F1 RBBP5 SMARCC2 CHD3 CHD4 CHD7 MECP2 TOP2B

4.31e-06384508int:SMARCC1
InteractionSF3B2 interactions

SNIP1 NEIL1 SURF6 H1-3 DAXX CHD3 CHD4 MECP2 TOP2A

4.41e-06517509int:SF3B2
InteractionPHF14 interactions

DAXX CHD3 CHD4 MECP2 RAI1

4.83e-06100505int:PHF14
InteractionRPL31 interactions

PDS5B SNIP1 GTF2F1 TCOF1 SURF6 H1-3 CHD3 CHD4 TOP2A TOP2B

5.43e-066805010int:RPL31
InteractionSMARCD2 interactions

SNIP1 RBBP5 SMARCC2 CHD4 MECP2 TOP2B

5.89e-06183506int:SMARCD2
InteractionRBBP5 interactions

TCOF1 RBBP5 SMARCC2 CHD3 CHD7 MECP2 TOP2A

6.53e-06287507int:RBBP5
InteractionRPLP2 interactions

RBBP5 NEIL1 SURF6 MACROH2A2 CHD3 CHD4 MECP2 TOP2A

6.84e-06409508int:RPLP2
InteractionDDX51 interactions

NEIL1 SURF6 MACROH2A2 CHD3 MECP2

7.04e-06108505int:DDX51
InteractionCEBPA interactions

PDS5B GTF2F1 SAFB ZBTB40 PHF6 SMARCC2 CHD3 CHD4 CHD7 MECP2 TOP2A TOP2B RAI1

7.42e-0612455013int:CEBPA
InteractionTERF2IP interactions

PDS5B SNIP1 GTF2F1 SMARCC2 CHD3 CHD7 HMGN3 TOP2A RAI1

7.49e-06552509int:TERF2IP
InteractionRPS6 interactions

PDS5B SNIP1 SURF6 PHF6 DAXX CHD3 CHD4 CHD6 MECP2 TOP2A TOP2B

7.58e-068745011int:RPS6
InteractionSRPK2 interactions

SNIP1 SAFB TCOF1 NEIL1 SURF6 PHF6 MACROH2A2 HMGN3 TOP2A TOP2B

8.64e-067175010int:SRPK2
InteractionDDX21 interactions

SNIP1 IBTK SAFB NEIL1 SURF6 MACROH2A2 CHD3 CHD4 MECP2 TOP2A

8.75e-067185010int:DDX21
InteractionNAT10 interactions

IBTK RBBP5 NEIL1 SURF6 CHD3 CHD4 MECP2

9.10e-06302507int:NAT10
InteractionH3-5 interactions

H1-3 DAXX MACROH2A2 CHD4 TOP2B

9.17e-06114505int:H3-5
InteractionSAP18 interactions

SNIP1 SAFB RBBP5 SMARCC2 CHD3 CHD4 MECP2

9.71e-06305507int:SAP18
InteractionRPL27 interactions

SNIP1 TCOF1 CHD3 CHD4 MECP2 TOP2A TOP2B RAI1

1.00e-05431508int:RPL27
InteractionMTA2 interactions

RBBP5 SMARCC2 CHD3 CHD4 CHD7 MECP2 TOP2A TOP2B

1.07e-05435508int:MTA2
InteractionBAZ1B interactions

SMARCC2 DAXX CHD3 CHD4 TOP2A TOP2B

1.10e-05204506int:BAZ1B
InteractionRPL22 interactions

GTF2F1 SURF6 H1-3 PHF6 CHD3 CHD4 MECP2 TOP2A

1.16e-05440508int:RPL22
InteractionNUMA1 interactions

RBBP5 H1-3 MACROH2A2 CHD3 CHD4 TOP2A TOP2B RAI1

1.84e-05469508int:NUMA1
InteractionRPS17 interactions

NEIL1 SURF6 H1-3 CHD3 CHD4 MECP2 TOP2A

1.85e-05337507int:RPS17
InteractionGATAD2A interactions

RBBP5 SMARCC2 CHD3 CHD4 CHD7 TOP2A

1.86e-05224506int:GATAD2A
InteractionRPF1 interactions

NEIL1 SURF6 H1-3 MACROH2A2 MECP2

1.87e-05132505int:RPF1
InteractionCSNK2B interactions

TCOF1 RBBP5 NEIL1 DAXX CHD4 MECP2 TOP2A TOP2B ADD1

2.01e-05625509int:CSNK2B
InteractionPRC1 interactions

PDS5B IQCA1L SAFB KIF3B H1-3 MACROH2A2 CHD4 MECP2 HMGN3 TOP2A TOP2B

2.07e-059735011int:PRC1
InteractionMYCN interactions

PDS5B SNIP1 SAFB TCOF1 SURF6 PHF6 SMARCC2 DAXX MACROH2A2 CHD4 CHD7 MECP2 RAI1

2.12e-0513735013int:MYCN
InteractionRSL1D1 interactions

SNIP1 NEIL1 SURF6 H1-3 DAXX CHD3 CHD4 CREBL2

2.15e-05479508int:RSL1D1
InteractionUTP14A interactions

SNIP1 SAFB CHD3 CHD4 MECP2 TOP2B

2.16e-05230506int:UTP14A
InteractionNAA40 interactions

IBTK SAFB TCOF1 SURF6 PHF6 CHD3 CHD4 MECP2 TOP2A TOP2B ADD1

2.17e-059785011int:NAA40
InteractionTENT4B interactions

NEIL1 SURF6 H1-3 MACROH2A2 CHD6

2.32e-05138505int:TENT4B
InteractionRPL6 interactions

SNIP1 IBTK GTF2F1 SURF6 H1-3 CHD3 CHD4 MECP2 TOP2A

2.34e-05637509int:RPL6
InteractionSNRNP40 interactions

SNIP1 GTF2F1 TCOF1 SURF6 SMARCC2 CHD3 MECP2 TOP2A TOP2B

2.34e-05637509int:SNRNP40
InteractionDOT1L interactions

IBTK SAFB TCOF1 SURF6 SMARCC2 DAXX CHD3 CHD4 TOP2A TOP2B

2.40e-058075010int:DOT1L
Cytoband12p13

PDE6H CHD4 CREBL2

4.83e-056450312p13
Cytoband6q14.1

IBTK HMGN3

3.16e-04245026q14.1
GeneFamilyTopoisomerases

TOP2A TOP2B

4.25e-0563121050
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

SMARCC2 CHD6 CHD7

1.01e-0453313532
GeneFamilyPHD finger proteins|NuRD complex

CHD3 CHD4

1.86e-04123121305
GeneFamilyPHD finger proteins

PHF6 CHD3 CHD4

4.85e-049031388
CoexpressionGSE40068_CXCR5POS_BCL6POS_TFH_VS_CXCR5NEG_BCL6NEG_CD4_TCELL_UP

IBTK CNST PNRC1 PLCB2 CHD7 CREBL2 ADD1

1.03e-07200507M9258
CoexpressionGSE20727_H2O2_VS_ROS_INHIBITOR_TREATED_DC_UP

CNST ZBTB40 PRR22 CHD7 MECP2 TOP2B

2.14e-06199506M9255
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#4

PDS5B KIF3B ARID4A SETD5 RBBP5 TRO CHD4 CHD7 TOP2A

9.01e-06595509Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K4
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5

PDS5B ARID4A SETD5 RBBP5 TRO SMARCC2 PNRC1 CHD7 NLGN1

1.40e-05629509Facebase_RNAseq_e10.5_Maxillary Arch_2500_K5
CoexpressionAtlasFacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2

PDS5B ARID4A SETD5 TRO PHF6 PNRC1 CHD7 TOP2A

4.74e-05564508Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_1000

PDE6H ARID4A SETD5 RBBP5 TRO TOX3 H1-3 PNRC1 CHD7 TOX2

7.92e-059795010Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_1000
CoexpressionAtlasFacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_1000_k-means-cluster#4

ARID4A SETD5 TRO PNRC1 CHD7

1.14e-04203505Facebase_RNAseq_e9.5_Mandibular Arch_1000_K4
CoexpressionAtlasFacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000_k-means-cluster#2

TOX3 CHD3 CHD7 NLGN1 TOX2

1.33e-04210505Facebase_RNAseq_e9.5_Olfactory Placode_1000_K2
CoexpressionAtlasFacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_1000_k-means-cluster#2

TOX3 CHD3 CHD7 NLGN1 TOX2

2.88e-04248505Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_1000_K2
ToppCellCV-Mild-3|Mild / Virus stimulation, Condition and Cluster

TCOF1 NEIL1 NAP1L3 TOP2A

3.61e-051665045599f90fc0e15a3670b03187085eba91228390a2
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCOF1 H1-3 CHD4 TOP2A

4.24e-05173504a5172dee859bf6c2eed46c48bd64dfef0ff9f28f
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCOF1 H1-3 CHD4 TOP2A

4.24e-05173504639b5b0b33ce5aa0bc26363c059717012ddc14c0
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNRC1 CHD3 CHD4 TOP2B

5.16e-051825041710eab3037a87609d21838be2d2d29c3bc36651
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c13-HAVCR2|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IBTK H1-3 TOX2 TOP2A

5.16e-051825046c9a48037fa002bc528875538bdaaf15696d68b6
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNRC1 CHD3 CHD4 TOP2B

5.16e-05182504e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCOF1 PNRC1 CHD4 TOP2B

5.50e-051855047adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellNeuron-Postmitotic-Inhibitory_Neuron-SST-MGE1-4|World / Primary Cells by Cluster

PNRC1 CHD6 CHD7 TOX2

6.48e-051935042eb6e4cff4fe3ce564c1581f6f7df4834895aaa9
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_OPC-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TOX3 NAP1L3 CHD7 TOP2B

7.01e-05197504d9a5b6171867de21d4ef12aa5a802fb4de9e0c00
ToppCellmild-dn_T|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

H1-3 ZBTB40 TOX2 TOP2A

7.01e-0519750407a1f59c83b748825e0708cd1cc7b63a2cb856cc
ToppCellerythropoietic-Basophilic_Erythroblast|erythropoietic / Lineage and Cell class

PNRC1 CHD4 HMGN3 TOP2B

7.29e-0519950439c4adef3e02f948414f866aa22ac76f44b7b7db
ToppCell10x3'2.3-week_12-13-Lymphocytic_B-B_lineage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

H1-3 HMGN3 TOP2A TOP2B

7.29e-05199504fe3b7d540a644dfc6beea171c809b4d1ba4e188f
ToppCell10x3'2.3-week_12-13-Lymphocytic_B|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

H1-3 HMGN3 TOP2A TOP2B

7.29e-05199504cdee798e3586e4e7a15de598239090a85752ea1e
DrugDB08184

PDS5B H1-3 MACROH2A2 CHD3 CHD4 MECP2

1.53e-06167496CID009547945
DrugDexrazoxane

TOP2A TOP2B

4.54e-062492DB00380
DrugF14512

TOP2A TOP2B

4.54e-062492ctd:C534191
DrugDaunorubicin

TOP2A TOP2B

4.54e-062492DB00694
DrugDigoxin [20830-75-5]; Up 200; 5.2uM; MCF7; HT_HG-U133A

SNIP1 ARID4A H1-3 ZBTB40 PNRC1

2.85e-051664955324_UP
Diseaseacute myeloid leukemia (implicated_via_orthology)

ARID4A TOP2A TOP2B

8.80e-0712483DOID:9119 (implicated_via_orthology)
DiseaseB cell deficiency (implicated_via_orthology)

TOP2A TOP2B

2.59e-062482DOID:2115 (implicated_via_orthology)
DiseaseCHARGE syndrome (implicated_via_orthology)

CHD6 CHD7

5.41e-057482DOID:0050834 (implicated_via_orthology)
Diseasecongenital heart disease (implicated_via_orthology)

PLCB2 CHD6 CHD7

1.96e-0469483DOID:1682 (implicated_via_orthology)
DiseaseCoffin-Siris syndrome

PHF6 SMARCC2

2.00e-0413482C0265338
DiseaseAdrenocortical carcinoma

DAXX TOP2A

3.90e-0418482C0206686
DiseaseIntellectual Disability

ZBTB40 SMARCC2 CHD3 MECP2 RAI1

7.82e-04447485C3714756
DiseaseChild Development Disorders, Specific

CHD4 MECP2

1.02e-0329482C0085997
DiseaseChild Development Deviations

CHD4 MECP2

1.02e-0329482C0085996
DiseaseDevelopmental Disabilities

CHD4 MECP2

1.09e-0330482C0008073
DiseaseMental Retardation, Psychosocial

ZBTB40 MECP2 RAI1

1.52e-03139483C0025363
DiseaseProfound Mental Retardation

ZBTB40 MECP2 RAI1

1.52e-03139483C0020796
DiseaseMental deficiency

ZBTB40 MECP2 RAI1

1.52e-03139483C0917816

Protein segments in the cluster

PeptideGeneStartEntry
AEKSPKGKGRRSKTK

ARID4A

786

P29374
KPKHSSPGKKPAGRK

CXorf49;

371

A8MYA2
SGKKGGKKSKAAKPR

MACROH2A2

141

Q9P0M6
KKRSLAKKGRKGSIP

CFAP46

2386

Q8IYW2
SAPVPRGRKGKKVKA

CHD7

1686

Q9P2D1
GPPCKKSRKEKKQTG

DAXX

626

Q9UER7
AFKSGKRVGKPSPKA

RAI1

1091

Q7Z5J4
SKKGSKKKSGPPAPE

PDS5B

1311

Q9NTI5
GPLAPKGRKSRKKKS

NEIL1

286

Q96FI4
KKKKSGSEKNTGRPP

HECA

201

Q9UBI9
KAKKKPRKRSDSSGG

IBTK

981

Q9P2D0
APSRKKKGSKGPVIK

KRT80

421

Q6KB66
GKGKPKPKVPERKSS

NHSL1

881

Q5SYE7
AGGTPRAAPKKRRKK

PNRC1

86

Q12796
PKPRKTSAKKEPGAK

HMGN3

41

Q15651
PGKKICRKGGPLTKK

NLGN1

176

Q8N2Q7
RPKGSKGKEKDSPFK

RBBP5

486

Q15291
GAAKGSKDREPKPKR

CHD6

106

Q8TD26
KEGKGPGHKRRSKSP

CHD3

261

Q12873
VKKPGKRGRKPAKID

CREBL2

11

O60519
ASKKAGPKSSPRKPV

COL27A1

541

Q8IZC6
PGHKKRGPSKKKPGA

GCNA

466

Q96QF7
RGPSKKKPGAAKVEK

GCNA

471

Q96QF7
EGKPKAKKAGAAKPR

H1-3

116

P16402
AKKAGAAKPRKPAGA

H1-3

121

P16402
AAKPRKPAGAAKKPK

H1-3

126

P16402
KPAGAAKKPKKVAGA

H1-3

131

P16402
KTKEGKGPNARRKPK

CHD4

261

Q14839
KKIPGKRSPRSKKGT

CNST

106

Q6PJW8
KRSPRSKKGTAKKIP

CNST

111

Q6PJW8
KSGKGLKTCKSPGRK

MECP2

331

P51608
VPKAKKKAPLAKGGR

GTF2F1

231

P35269
SPPKKKNKASGRRSK

SNIP1

76

Q8TAD8
PKKTTTPKGKGRGAK

TOP2B

1531

Q02880
TPKGKGRGAKKRKAS

TOP2B

1536

Q02880
ARTPRSKKKKKLGAG

TCOF1

1356

Q13428
KPLKRFKRAAGKKGA

LRRC41

386

Q15345
KPKRKRTGSDSKSGK

NKX1-1

281

Q15270
PLRAPKKTPGKKTGK

IQCA1L

461

A6NCM1
ASKGKPRLPKASPKA

PKDREJ

1501

Q9NTG1
KRKKSPEKGRAAPKT

SETD5

171

Q9C0A6
KDRRAKGTPKSSKPG

SLCO6A1

31

Q86UG4
KRARKGKPKREDPKG

NAP1L3

296

Q99457
QGSETAGPPKKKRKK

SURF6

36

O75683
KKGGNYKKRKRSPSP

SMARCC2

291

Q8TAQ2
GNKKTSKRSSKGRKP

SAFB

81

Q15424
PGKSPSKKKKKFRTP

ADD1

711

P35611
TRQFKSKPPKKGVKG

PDE6H

31

Q13956
KASTAKKGKPGRKAR

PRR22

386

Q8IZ63
PKSKKKSRKGRPRKT

PHF6

156

Q8IWS0
RPKKSKGKKAASRGP

TRO

296

Q12816
KKSKARPKSGRKSGS

KIF3B

711

O15066
KRAAPDSGKKPKTPK

TOX3

231

O15405
PPAAKRRKTDTKGKK

nan

66

A6NLC8
KLGPGKGSRKKRSLP

PLCB2

946

Q00722
GAKKRAAPKGTKRDP

TOP2A

1431

P11388
KRPSADPGKKAKNPK

TOX2

231

Q96NM4
AGGEPDAPKKKKKRL

ZBTB40

791

Q9NUA8