Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF208 ZNF221 ZSCAN20 KLF10 ZNF876P ZNF732 EP300 NOTCH1 ZNF331 ZNF707

2.53e-0512713310GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF208 ZNF221 ZSCAN20 KLF10 ZNF876P ZNF732 ZNF875 NOTCH1 ZNF331 ZNF707

6.22e-0514123310GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF208 ZNF221 ZSCAN20 KLF10 ZNF876P ZNF732 ZNF875 EP300 ZNF331 ZNF707

8.20e-0514593310GO:0000977
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF208 ZNF221 ZSCAN20 KLF10 ZNF876P ZNF732 EP300 ZNF331 ZNF707

1.35e-041244339GO:0000978
GeneOntologyMolecularFunctionstructural constituent of postsynaptic actin cytoskeleton

POTEE POTEF

1.44e-0411332GO:0098973
GeneOntologyMolecularFunctionsemaphorin receptor binding

SEMA6A SEMA6D

6.56e-0423332GO:0030215
GeneOntologyMolecularFunctionchemorepellent activity

SEMA6A SEMA6D

1.05e-0329332GO:0045499
GeneOntologyMolecularFunctionstructural constituent of postsynapse

POTEE POTEF

1.27e-0332332GO:0099186
GeneOntologyMolecularFunctionstructural constituent of synapse

POTEE POTEF

2.19e-0342332GO:0098918
GeneOntologyBiologicalProcessaxonogenesis

POTEE SEMA6A SEMA6D POTEF EP300 NOTCH1 EPHA8

2.59e-05566337GO:0007409
GeneOntologyBiologicalProcessaxon development

POTEE SEMA6A SEMA6D POTEF EP300 NOTCH1 EPHA8

5.78e-05642337GO:0061564
GeneOntologyBiologicalProcessneuron development

CFH POTEE SEMA6A SETX SEMA6D OTOGL POTEF EP300 NOTCH1 EPHA8

6.38e-0514633310GO:0048666
GeneOntologyBiologicalProcessneuron projection development

POTEE SEMA6A SETX SEMA6D OTOGL POTEF EP300 NOTCH1 EPHA8

1.36e-041285339GO:0031175
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

POTEE SEMA6A SEMA6D POTEF EP300 NOTCH1 EPHA8

1.50e-04748337GO:0048667
GeneOntologyBiologicalProcessneuron projection morphogenesis

POTEE SEMA6A SEMA6D POTEF EP300 NOTCH1 EPHA8

2.31e-04802337GO:0048812
GeneOntologyBiologicalProcesscellular response to follicle-stimulating hormone stimulus

NOTCH1 EPHA8

2.57e-0415332GO:0071372
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

POTEE SEMA6A SEMA6D POTEF EP300 NOTCH1 EPHA8

2.62e-04819337GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

POTEE SEMA6A SEMA6D POTEF EP300 NOTCH1 EPHA8

2.76e-04826337GO:0048858
GeneOntologyCellularComponenthistone acetyltransferase complex

POTEE POTEF EP300

4.36e-0494333GO:0000123
GeneOntologyCellularComponentprotein acetyltransferase complex

POTEE POTEF EP300

5.86e-04104333GO:0031248
GeneOntologyCellularComponentacetyltransferase complex

POTEE POTEF EP300

6.71e-04109333GO:1902493
GeneOntologyCellularComponentH4/H2A histone acetyltransferase complex

POTEE POTEF

1.16e-0332332GO:0043189
GeneOntologyCellularComponentNuA4 histone acetyltransferase complex

POTEE POTEF

1.16e-0332332GO:0035267
GeneOntologyCellularComponentblood microparticle

CFH POTEE POTEF

1.50e-03144333GO:0072562
GeneOntologyCellularComponentH4 histone acetyltransferase complex

POTEE POTEF

2.29e-0345332GO:1902562
HumanPhenoAbnormal heart morphology

ALPK3 FBN1 EP300 NOTCH1 GNPTAB

1.27e-05184105HP:3000001
HumanPhenoHeart murmur

FBN1 NOTCH1 GNPTAB

4.80e-0539103HP:0030148
HumanPhenoAbnormal heart sound

FBN1 NOTCH1 GNPTAB

6.01e-0542103HP:0031657
HumanPhenoAbnormal mitral valve morphology

ALPK3 FBN1 EP300 NOTCH1 GNPTAB

6.43e-05257105HP:0001633
HumanPhenoRight ventricular hypertrophy

ALPK3 NOTCH1 GNPTAB

7.41e-0545103HP:0001667
HumanPhenoMegalocornea

FBN1 NSD2 GNPTAB

1.28e-0454103HP:0000485
HumanPhenoAnterior chamber mesodermal anomalies

FBN1 NSD2 GNPTAB

1.28e-0454103HP:0008040
HumanPhenoHemangioma

NSD2 EP300 NOTCH1 GNPTAB

1.36e-04151104HP:0001028
HumanPhenoVascular neoplasm

NSD2 EP300 NOTCH1 GNPTAB

1.50e-04155104HP:0100742
HumanPhenoAbnormal pulmonary valve physiology

FBN1 EP300 NOTCH1 GNPTAB

1.83e-04163104HP:0031654
HumanPhenoAbnormality of prenatal development or birth

ALPK3 CFH SETX FBN1 NSD2 EP300 NOTCH1 GNPTAB

2.03e-041159108HP:0001197
HumanPhenoSplit hand

NSD2 NOTCH1 GNPTAB

2.34e-0466103HP:0001171
HumanPhenoCardiac valve calcification

FBN1 NOTCH1

2.67e-0413102HP:0005146
HumanPhenoLimited shoulder movement

FBN1 GNPTAB

2.67e-0413102HP:0006467
HumanPhenoAbnormal mitral valve physiology

ALPK3 FBN1 NOTCH1 GNPTAB

2.68e-04180104HP:0031481
HumanPhenoAbnormal atrioventricular valve morphology

ALPK3 FBN1 EP300 NOTCH1 GNPTAB

2.81e-04350105HP:0006705
HumanPhenoAbnormal spinal cord morphology

SETX FBN1 NSD2 EP300 GNPTAB

3.09e-04357105HP:0002143
HumanPhenoAbnormal shoulder physiology

FBN1 GNPTAB

3.12e-0414102HP:0033129
HumanPhenoAbnormal heart valve morphology

ALPK3 FBN1 NSD2 EP300 NOTCH1 GNPTAB

3.22e-04588106HP:0001654
HumanPhenoAplasia of the toes

NSD2 EP300 NOTCH1

3.28e-0474103HP:0011306
HumanPhenoEctrodactyly

NSD2 NOTCH1 GNPTAB

3.28e-0474103HP:0100257
HumanPhenoAbsent toe

NSD2 EP300 NOTCH1

3.28e-0474103HP:0010760
HumanPhenoAbnormal aortic valve physiology

FBN1 EP300 NOTCH1 GNPTAB

3.44e-04192104HP:0031652
HumanPhenoNeoplasm of the skin

BLNK NSD2 EP300 NOTCH1 GNPTAB

3.47e-04366105HP:0008069
HumanPhenoAbnormal pulmonary valve morphology

FBN1 EP300 NOTCH1 GNPTAB

3.87e-04198104HP:0001641
HumanPhenoAbnormal atrioventricular valve physiology

ALPK3 FBN1 NOTCH1 GNPTAB

5.30e-04215104HP:0031650
HumanPhenoAbnormal heart valve physiology

ALPK3 FBN1 EP300 NOTCH1 GNPTAB

5.46e-04403105HP:0031653
HumanPhenoAbnormal right ventricle morphology

ALPK3 NOTCH1 GNPTAB

6.04e-0491103HP:0001707
HumanPhenoSpondylolisthesis

FBN1 GNPTAB

6.47e-0420102HP:0003302
HumanPhenoAbnormal morphology of bones of the upper limbs

FBN1 NSD2 EP300 NOTCH1 GNPTAB

7.87e-04436105HP:0040065
HumanPhenoAbnormal left ventricle morphology

ALPK3 FBN1 NOTCH1 GNPTAB

7.93e-04239104HP:0001711
HumanPhenoPreeclampsia

CFH EP300

8.59e-0423102HP:0100602
HumanPhenoAortic regurgitation

FBN1 NOTCH1 GNPTAB

8.69e-04103103HP:0001659
HumanPhenoEctopia pupillae

FBN1 NSD2

9.36e-0424102HP:0009918
HumanPhenoAscending aortic dissection

FBN1 NOTCH1

1.10e-0326102HP:0004933
HumanPhenoAortic valve stenosis

FBN1 EP300 NOTCH1

1.14e-03113103HP:0001650
HumanPhenoFlared iliac wing

EP300 GNPTAB

1.19e-0327102HP:0002869
HumanPhenoBroad ribs

FBN1 GNPTAB

1.19e-0327102HP:0000885
HumanPhenoAbnormal ascending aorta morphology

FBN1 NOTCH1

1.19e-0327102HP:0031784
HumanPhenoSmall for gestational age

FBN1 NSD2 EP300 GNPTAB

1.22e-03268104HP:0001518
HumanPhenoAbnormal upper limb bone morphology

FBN1 NSD2 EP300 NOTCH1 GNPTAB

1.28e-03484105HP:0040070
HumanPhenoCalvarial skull defect

NSD2 NOTCH1

1.28e-0328102HP:0001362
HumanPhenoMitral stenosis

FBN1 NOTCH1

1.28e-0328102HP:0001718
HumanPhenoToxemia of pregnancy

CFH EP300

1.28e-0328102HP:0100603
HumanPhenoBicuspid aortic valve

FBN1 EP300 NOTCH1

1.32e-03119103HP:0001647
HumanPhenoAbnormal aortic valve cusp morphology

FBN1 EP300 NOTCH1

1.39e-03121103HP:0031567
HumanPhenoAbnormal cellular immune system morphology

BLNK CFH SETX NSD2 EP300 NOTCH1

1.46e-03774106HP:0010987
HumanPhenoAbnormal leukocyte morphology

BLNK CFH SETX NSD2 EP300 NOTCH1

1.46e-03774106HP:0001881
HumanPhenoAbnormality of the glabella

FBN1 NSD2

1.47e-0330102HP:0002056
HumanPhenoPreaxial foot polydactyly

NSD2 EP300

1.47e-0330102HP:0001841
HumanPhenoAbnormal cheek morphology

FBN1 NSD2 EP300 GNPTAB

1.48e-03282104HP:0004426
HumanPhenoAnterior bulging of the globe

FBN1 NSD2 EP300 GNPTAB

1.50e-03283104HP:0000644
HumanPhenoProptosis

FBN1 NSD2 EP300 GNPTAB

1.50e-03283104HP:0000520
HumanPhenoAbnormal cardiac ventricle morphology

ALPK3 FBN1 NSD2 EP300 NOTCH1 GNPTAB

1.53e-03780106HP:0001713
HumanPhenoCavernous hemangioma

NOTCH1 GNPTAB

1.56e-0331102HP:0001048
HumanPhenoShort thumb

FBN1 NSD2 EP300

1.60e-03127103HP:0009778
HumanPhenoAbnormal cardiac septum morphology

ALPK3 FBN1 NSD2 EP300 NOTCH1 GNPTAB

1.60e-03787106HP:0001671
HumanPhenoAbnormal aortic valve morphology

FBN1 EP300 NOTCH1 GNPTAB

1.62e-03289104HP:0001646
HumanPhenoAbnormal immune system morphology

BLNK CFH SETX NSD2 EP300 NOTCH1

1.73e-03798106HP:0032251
HumanPhenoAbnormal ventricular septum morphology

ALPK3 FBN1 NSD2 EP300 NOTCH1

1.79e-03521105HP:0010438
HumanPhenoAplasia/Hypoplasia involving bones of the feet

FBN1 NSD2 EP300 NOTCH1

1.82e-03298104HP:0006494
HumanPhenoCardiomegaly

ALPK3 FBN1 GNPTAB

1.83e-03133103HP:0001640
HumanPhenoOvoid vertebral bodies

FBN1 GNPTAB

1.88e-0334102HP:0003300
HumanPhenoPatent foramen ovale

EP300 NOTCH1 GNPTAB

1.91e-03135103HP:0001655
HumanPhenoHypoplasia of the iris

FBN1 NSD2

1.99e-0335102HP:0007676
HumanPhenoPulmonic stenosis

FBN1 EP300 NOTCH1

2.03e-03138103HP:0001642
HumanPhenoAplasia/hypoplasia involving bones of the hand

FBN1 NSD2 EP300 NOTCH1 GNPTAB

2.07e-03538105HP:0005927
HumanPhenoShallow orbits

FBN1 GNPTAB

2.11e-0336102HP:0000586
HumanPhenoAplasia/Hypoplasia of toe

NSD2 EP300 NOTCH1

2.12e-03140103HP:0001991
HumanPhenoAccessory spleen

NSD2 EP300

2.23e-0337102HP:0001747
HumanPhenoShort hallux

NSD2 EP300

2.35e-0338102HP:0010109
HumanPhenoAbnormal mitral valve morphology

FBN1 EP300 NOTCH1

2.39e-03146103HP:0031477
HumanPhenoAbnormality of the liver

BLNK CFH FBN1 NSD2 EP300 NOTCH1 GNPTAB

2.46e-031205107HP:0001392
HumanPhenoCardiovascular calcification

FBN1 NOTCH1

2.47e-0339102HP:0011915
HumanPhenoAbnormal morphology of bony orbit of skull

FBN1 GNPTAB

2.47e-0339102HP:3000030
HumanPhenoCongenital onset

ALPK3 FBN1 OTOGL NSD2 EP300 NOTCH1 GNPTAB

2.48e-031206107HP:0003577
HumanPhenoShort finger

FBN1 NSD2 EP300 NOTCH1

2.51e-03325104HP:0009381
HumanPhenoAplasia/Hypoplasia of the thumb

FBN1 NSD2 EP300

2.58e-03150103HP:0009601
HumanPhenoSevere postnatal growth retardation

NSD2 GNPTAB

2.60e-0340102HP:0008850
HumanPhenoAortic dissection

FBN1 NOTCH1

2.60e-0340102HP:0002647
HumanPhenoFull cheeks

FBN1 EP300 GNPTAB

2.63e-03151103HP:0000293
MousePhenoabnormal skin turgor

FBN1 GNPTAB

2.91e-057172MP:0003652
MousePhenoincreased classified tumor incidence

BLNK SMAP1 KLF10 ING2 NOTCH1

6.92e-05381175MP:0010273
MousePhenoabnormal classified tumor incidence

BLNK SMAP1 KLF10 ING2 NOTCH1

7.18e-05384175MP:0020188
MousePhenoabnormal osteocyte morphology

KLF10 GNPTAB

1.45e-0415172MP:0008753
MousePhenoabnormal osteocyte lacunocanalicular system morphology

KLF10 GNPTAB

2.11e-0418172MP:0030485
MousePhenoabnormal eosinophil cell number

BLNK ZNF208 SETX EP300

2.13e-04255174MP:0002602
MousePhenodecreased bone volume

FBN1 KLF10 GNPTAB

2.25e-04100173MP:0010876
MousePhenoabnormal eosinophil morphology

BLNK ZNF208 SETX EP300

2.30e-04260174MP:0005061
MousePhenoabnormal heart ventricle morphology

ALPK3 FBN1 NSD2 FCRL6 EP300 NOTCH1

2.36e-04793176MP:0005294
MousePhenoabnormal granulocyte number

BLNK SMAP1 ZNF208 SETX FBN1 EP300

2.56e-04805176MP:0020201
MousePhenoabnormal granulocyte morphology

BLNK SMAP1 ZNF208 SETX FBN1 EP300

3.12e-04835176MP:0002441
MousePhenoincreased tumor incidence

BLNK SMAP1 KLF10 ING2 NOTCH1

3.26e-04530175MP:0002020
MousePhenoenlarged spleen

BLNK SMAP1 FBN1 ING2 NOTCH1 GNPTAB

3.71e-04862176MP:0000691
MousePhenoabnormal heart ventricle wall morphology

ALPK3 FBN1 FCRL6 EP300

3.77e-04296174MP:0031532
MousePhenoanemia

CFH SMAP1 EP300 NOTCH1

4.28e-04306174MP:0001577
MousePhenoabnormal myeloid leukocyte morphology

BLNK SMAP1 ZNF208 SETX FBN1 EP300 GNPTAB

4.80e-041292177MP:0008250
MousePhenoabnormal heart valve physiology

FBN1 NOTCH1

5.94e-0430172MP:0011926
MousePhenoabnormal tumor incidence

BLNK SMAP1 KLF10 ING2 NOTCH1

7.47e-04635175MP:0002019
MousePhenodecreased lymphocyte cell number

BLNK ZNF208 SETX FBN1 EP300 NOTCH1

7.88e-04992176MP:0005016
MousePhenoabnormal myeloblast morphology/development

BLNK ZNF208 SETX EP300

7.89e-04360174MP:0002414
MousePhenoabnormal tumor susceptibility

BLNK SMAP1 KLF10 ING2 NOTCH1

8.30e-04650175MP:0002166
MousePhenoincreased neutrophil cell number

BLNK SMAP1 SETX FBN1

8.57e-04368174MP:0000219
MousePhenoabnormal heart valve morphology

FBN1 EP300 NOTCH1

9.39e-04163173MP:0000285
MousePhenovisceromegaly

BLNK SMAP1 FBN1 ING2 NOTCH1 GNPTAB

9.62e-041030176MP:0013328
MousePhenoincreased leukemia incidence

BLNK SMAP1

1.00e-0339172MP:0002026
MousePhenointernal hemorrhage

CFH FBN1 EP300 NOTCH1

1.03e-03387174MP:0001634
MousePhenoabnormal bone volume

FBN1 KLF10 GNPTAB

1.11e-03173173MP:0010874
MousePhenoabnormal bone marrow cell morphology/development

BLNK SMAP1 ZNF208 SETX EP300

1.21e-03706175MP:0002398
MousePhenoincreased hemolymphoid system tumor incidence

BLNK SMAP1 ING2

1.48e-03191173MP:0010296
MousePhenoneoplasm

BLNK SMAP1 KLF10 ING2 NOTCH1

1.55e-03747175MP:0002006
MousePhenothick skin

FBN1 GNPTAB

1.78e-0352172MP:0001200
MousePhenoabnormal vasculogenesis

EP300 NOTCH1

1.92e-0354172MP:0001622
MousePhenokinked neural tube

EP300 NOTCH1

2.14e-0357172MP:0003400
MousePhenoabnormal spleen size

BLNK SMAP1 FBN1 ING2 NOTCH1 GNPTAB

2.16e-031203176MP:0002224
MousePhenoabnormal sensory neuron morphology

CFH SEMA6A NOTCH1 GNPTAB

2.17e-03473174MP:0000965
MousePhenodecreased trabecular bone volume

KLF10 GNPTAB

2.36e-0360172MP:0010879
MousePhenoabnormal pericardium morphology

FBN1 EP300 NOTCH1

2.37e-03225173MP:0000288
MousePhenoabnormal heart ventricle wall thickness

ALPK3 FCRL6 EP300

2.43e-03227173MP:0020135
MousePhenoabnormal cardiac muscle tissue morphology

ALPK3 FBN1 EP300 NOTCH1

2.45e-03489174MP:0010630
MousePhenoabnormal heart atrium morphology

FBN1 NSD2 EP300

2.58e-03232173MP:0003105
MousePhenoabnormal neutrophil cell number

BLNK SMAP1 SETX FBN1

2.64e-03499174MP:0012440
MousePhenoabnormal blood circulation

ALPK3 CFH FBN1 EP300 NOTCH1

2.68e-03845175MP:0002128
MousePhenoabnormal neutrophil morphology

BLNK SMAP1 SETX FBN1

2.87e-03511174MP:0005065
DomainKRAB

ZNF208 ZNF221 ZSCAN20 ZNF234 ZNF732 ZNF875 ZNF331 ZNF707

1.14e-07369318SM00349
DomainKRAB

ZNF208 ZNF221 ZSCAN20 ZNF234 ZNF732 ZNF875 ZNF331 ZNF707

1.17e-07370318IPR001909
Domain-

ZNF208 ZNF221 ZSCAN20 ZNF234 KLF10 ZNF732 ZNF875 ZNF331 ZNF707

1.03e-066793193.30.160.60
Domainzf-C2H2

ZNF208 ZNF221 ZSCAN20 ZNF234 KLF10 ZNF732 ZNF875 ZNF331 ZNF707

1.23e-06693319PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF208 ZNF221 ZSCAN20 ZNF234 KLF10 ZNF732 ZNF875 ZNF331 ZNF707

1.24e-06694319IPR013087
DomainKRAB

ZNF208 ZNF221 ZNF234 ZNF732 ZNF875 ZNF331 ZNF707

1.59e-06358317PS50805
DomainKRAB

ZNF208 ZNF221 ZNF234 ZNF732 ZNF875 ZNF331 ZNF707

1.59e-06358317PF01352
DomainZINC_FINGER_C2H2_2

ZNF208 ZNF221 ZSCAN20 ZNF234 KLF10 ZNF732 ZNF875 ZNF331 ZNF707

3.08e-06775319PS50157
DomainZINC_FINGER_C2H2_1

ZNF208 ZNF221 ZSCAN20 ZNF234 KLF10 ZNF732 ZNF875 ZNF331 ZNF707

3.15e-06777319PS00028
DomainZnf_C2H2-like

ZNF208 ZNF221 ZSCAN20 ZNF234 KLF10 ZNF732 ZNF875 ZNF331 ZNF707

3.84e-06796319IPR015880
DomainZnf_C2H2

ZNF208 ZNF221 ZSCAN20 ZNF234 KLF10 ZNF732 ZNF875 ZNF331 ZNF707

4.21e-06805319IPR007087
DomainZnF_C2H2

ZNF208 ZNF221 ZSCAN20 ZNF234 KLF10 ZNF732 ZNF875 ZNF331 ZNF707

4.34e-06808319SM00355
DomainLNR

NOTCH1 GNPTAB

2.66e-055312PS50258
DomainNotch_dom

NOTCH1 GNPTAB

5.57e-057312IPR000800
DomainNotch

NOTCH1 GNPTAB

5.57e-057312PF00066
DomainNL

NOTCH1 GNPTAB

5.57e-057312SM00004
DomainActin_CS

POTEE POTEF

3.15e-0416312IPR004001
DomainACTINS_2

POTEE POTEF

3.57e-0417312PS00432
DomainActin/actin-like_CS

POTEE POTEF

4.01e-0418312IPR020902
DomainACTINS_ACT_LIKE

POTEE POTEF

4.48e-0419312PS01132
DomainSemaphorin

SEMA6A SEMA6D

4.97e-0420312IPR027231
DomainEGF-like_CS

FBN1 CLEC18B NOTCH1 EPHA8

8.71e-04261314IPR013032
DomainEGF_2

FBN1 CLEC18B NOTCH1 EPHA8

9.22e-04265314PS01186
DomainSEMA

SEMA6A SEMA6D

1.20e-0331312PS51004
DomainActin

POTEE POTEF

1.20e-0331312IPR004000
DomainActin

POTEE POTEF

1.20e-0331312PF00022
DomainSema

SEMA6A SEMA6D

1.20e-0331312SM00630
DomainSemap_dom

SEMA6A SEMA6D

1.20e-0331312IPR001627
DomainACTIN

POTEE POTEF

1.20e-0331312SM00268
DomainSema

SEMA6A SEMA6D

1.20e-0331312PF01403
DomainPlexin_repeat

SEMA6A SEMA6D

1.28e-0332312IPR002165
DomainPSI

SEMA6A SEMA6D

1.28e-0332312PF01437
Domainzf-C2H2_6

ZNF208 ZNF234 ZNF732 ZNF331

1.72e-03314314PF13912
DomainPSI

SEMA6A SEMA6D

2.42e-0344312IPR016201
DomainPSI

SEMA6A SEMA6D

2.64e-0346312SM00423
DomainZinc_finger_PHD-type_CS

ING2 NSD2

5.20e-0365312IPR019786
DomainAnk_2

POTEE POTEF NOTCH1

5.33e-03215313PF12796
DomainAnk

POTEE POTEF NOTCH1

6.27e-03228313PF00023
DomainEGF_3

FBN1 CLEC18B NOTCH1

6.82e-03235313PS50026
DomainEGF

FBN1 CLEC18B NOTCH1

6.82e-03235313SM00181
DomainPHD

ING2 NSD2

6.86e-0375312PF00628
DomainZnf_PHD-finger

ING2 NSD2

7.59e-0379312IPR019787
Domain-

POTEE POTEF NOTCH1

7.90e-032483131.25.40.20
DomainEGF-like_dom

FBN1 CLEC18B NOTCH1

7.99e-03249313IPR000742
DomainANK

POTEE POTEF NOTCH1

8.17e-03251313SM00248
DomainANK_REPEAT

POTEE POTEF NOTCH1

8.35e-03253313PS50088
DomainAnkyrin_rpt-contain_dom

POTEE POTEF NOTCH1

8.44e-03254313IPR020683
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ZNF208 CPSF4 ZNF221 ZNF234 ING2 ZNF732 RBBP5 ZNF875 EP300 NOTCH1 ZNF331 ZNF707

3.34e-0613872712M734
PathwayREACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION

EP300 NOTCH1

9.82e-058272M48024
PathwayREACTOME_PI5P_REGULATES_TP53_ACETYLATION

ING2 EP300

1.26e-049272M27655
PathwayREACTOME_PI5P_REGULATES_TP53_ACETYLATION

ING2 EP300

1.26e-049272MM15357
PathwayREACTOME_RUNX3_REGULATES_NOTCH_SIGNALING

EP300 NOTCH1

1.57e-0410272MM15535
PathwayREACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES

EP300 NOTCH1

1.92e-0411272M48021
PathwayREACTOME_RUNX3_REGULATES_NOTCH_SIGNALING

EP300 NOTCH1

3.17e-0414272M27808
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS

EP300 NOTCH1

4.17e-0416272M27121
PathwayREACTOME_SIGNALING_BY_NOTCH1

EP300 NOTCH1

5.30e-0418272MM14775
PathwayREACTOME_OTHER_SEMAPHORIN_INTERACTIONS

SEMA6A SEMA6D

5.92e-0419272M10959
PathwayREACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

EP300 NOTCH1

6.57e-0420272M27881
PathwayREACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

EP300 NOTCH1

1.03e-0325272M27880
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

RBBP5 EP300

1.12e-0326272MM14793
Pubmed

A primate-specific POTE-actin fusion protein plays a role in apoptosis.

POTEE POTEF

8.73e-07233219669888
Pubmed

Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D.

SEMA6A SEMA6D

2.62e-06333228453731
Pubmed

Evolution and expression of chimeric POTE-actin genes in the human genome.

POTEE POTEF

2.62e-06333217101985
Pubmed

ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation.

ING2 EP300

2.62e-06333216024799
Pubmed

p300 acts as a transcriptional coactivator for mammalian Notch-1.

EP300 NOTCH1

2.62e-06333211604511
Pubmed

Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis.

ING2 EP300

2.62e-06333216782091
Pubmed

Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma.

NSD2 EP300

5.23e-06433233589584
Pubmed

p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro.

EP300 NOTCH1

5.23e-06433212391150
Pubmed

Ubiquitination of Notch1 is regulated by MAML1-mediated p300 acetylation of Notch1.

EP300 NOTCH1

5.23e-06433222100894
Pubmed

Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor.

EP300 NOTCH1

8.72e-06533211564735
Pubmed

Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.

EP300 NOTCH1

1.31e-05633219838210
Pubmed

Notch1 haploinsufficiency causes ascending aortic aneurysms in mice.

FBN1 NOTCH1

1.83e-05733229093270
Pubmed

Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation.

NSD2 EP300

1.83e-05733224101509
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

SEMA6A SEMA6D EP300 NOTCH1 EPHA8

2.10e-0535833532460013
Pubmed

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.

EP300 NOTCH1

4.78e-051133215546612
Pubmed

On and off retinal circuit assembly by divergent molecular mechanisms.

SEMA6A SEMA6D

5.73e-051233224179230
Pubmed

The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors.

CPSF4 RBBP5

7.89e-051433219136632
Pubmed

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.

SEMA6A SEMA6D EPHA8

8.93e-059133328558017
Pubmed

Identification of a novel actin isoform in hepatocellular carcinoma.

POTEE POTEF

9.10e-051533216824795
Pubmed

SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.

RBBP5 EP300

1.04e-041633223870121
Pubmed

Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.

SEMA6A SEMA6D

1.04e-041633222632726
Pubmed

Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

ZNF221 ZNF234

1.64e-042033212743021
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

CPSF4 ZNF221 SETX ING2 RBBP5 NSD2 EP300

1.77e-04129433730804502
Pubmed

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

SEMA6A SEMA6D EPHA8

1.88e-0411733317145500
Pubmed

Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability.

BLNK FBN1

1.99e-042233215733672
Pubmed

The structural role of radial glial endfeet in confining spinal motor neuron somata is controlled by the Reelin and Notch pathways.

SEMA6A NOTCH1

2.80e-042633223988635
Pubmed

Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.

SEMA6A SEMA6D

3.25e-042833218617019
Pubmed

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.

CFH POTEE POTEF

3.39e-0414333322516433
Pubmed

Heritable Thoracic Aortic Disease Overview

FBN1 NOTCH1

3.74e-043033220301299
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

BLNK SEMA6A NSD2 ZNF875 EP300 LMLN ZNF331

4.17e-04148933728611215
Pubmed

Hypertrophic Cardiomyopathy Overview

ALPK3 KLF10

4.81e-043433220301725
Pubmed

Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice.

SEMA6A SEMA6D

5.09e-043533228172500
Pubmed

Gene expression analysis of the embryonic subplate.

CFH CPSF4 SEMA6D

8.49e-0419633321862448
Pubmed

TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.

SEMA6A SEMA6D

9.19e-044733235462405
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF208 CPSF4 ZSCAN20 KLF10 ING2

9.25e-0480833520412781
Cytoband4p16.3

ZNF876P ZNF732 NSD2

3.21e-05853334p16.3
Cytoband15q21.1

FBN1 SEMA6D

3.28e-043733215q21.1
CytobandEnsembl 112 genes in cytogenetic band chr4p16

ZNF876P ZNF732 NSD2

5.47e-04222333chr4p16
Cytoband1q32

CFH RBBP5

5.77e-04493321q32
Cytoband2q21.1

POTEE POTEF

8.08e-04583322q21.1
CytobandEnsembl 112 genes in cytogenetic band chr2q21

POTEE POTEF

5.31e-03151332chr2q21
CytobandEnsembl 112 genes in cytogenetic band chr15q21

FBN1 SEMA6D

7.21e-03177332chr15q21
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF208 ZNF221 ZSCAN20 ZNF234 KLF10 ZNF732 ZNF875 ZNF331 ZNF707

8.18e-0771828928
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTEE POTEF

1.79e-0413282685
GeneFamilyImmunoglobulin like domain containing|Semaphorins

SEMA6A SEMA6D

4.32e-0420282736
GeneFamilyAnkyrin repeat domain containing

POTEE POTEF NOTCH1

6.06e-03242283403
GeneFamilyPHD finger proteins

ING2 NSD2

8.52e-039028288
Diseasesemaphorin-6A measurement

CFH SEMA6A

6.40e-064312EFO_0020721
DiseaseFc receptor-like protein 6 measurement

CFH FCRL6

6.40e-064312EFO_0801600
Diseasebifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 measurement

CFH GNPTAB

2.24e-057312EFO_0802332
Diseasearylsulfatase A measurement

CFH GNPTAB

2.98e-058312EFO_0020163
Diseasemembranoproliferative glomerulonephritis (implicated_via_orthology)

CFH EP300

4.78e-0510312DOID:2920 (implicated_via_orthology)
Diseaseinterleukin-8 measurement

CFH EPHA8

4.87e-0431312EFO_0004811
DiseaseNeoplasm of uncertain or unknown behavior of breast

EP300 NOTCH1

8.54e-0441312C0496956
DiseaseBreast adenocarcinoma

EP300 NOTCH1

8.54e-0441312C0858252

Protein segments in the cluster

PeptideGeneStartEntry
WPAGFVCDGCLKKSA

EP300

1266

Q09472
GKPLESYCSREWGCA

ALPK3

1726

Q96L96
TTCWDGKLEYPTCAK

CFH

1216

P08603
FPCCRGSSKSKVGAW

POTEF

106

A5A3E0
CYERLGCFKDGLPWT

PNLIPRP3

21

Q17RR3
TLTEYKCRCPPGWSG

NOTCH1

121

P46531
GCPGSWIKDGYCDKA

GNPTAB

441

Q3T906
KCERKLSYPDWGSGC

LMLN

536

Q96KR4
CIPGAKEGDSGLYWC

FCRL6

166

Q6DN72
SCLGLGKRPFGKWEC

NSD2

1266

O96028
GKWYCPKCRGDNEKT

ING2

251

Q9H160
RTPWKKCCFSGDGEY

RBBP5

251

Q15291
FPCCRGSGKSKVGAW

POTEE

106

Q6S8J3
VLCKPWYAGACDRKS

BLNK

341

Q8WV28
FKCSCSPGWIGDGIK

FBN1

1346

P35555
YCSAEGEWLVPIGKC

EPHA8

246

P29322
EKPFSCSWKGCERRF

KLF10

396

Q13118
IKDCPWYDRGFCKHG

CPSF4

121

O95639
NWGESKIKGSCPYEC

OTOGL

71

Q3ZCN5
WRTPDYCSLSCPEGK

OTOGL

1796

Q3ZCN5
KDSGWRTAICPDYCP

SETX

366

Q7Z333
IPYKKGAWCSLCTAS

CLEC18B

196

Q6UXF7
YTCAECGKSFRWPKG

ZNF707

316

Q96C28
PYKCKECGKAFRWSR

ZNF876P

146

Q49A33
RIHTGEKPYKCGECW

ZSCAN20

786

P17040
CKKTCIASRDPYCGW

SEMA6A

521

Q9H2E6
PYECKDCGKAFRWGS

ZNF331

186

Q9NQX6
PHECKECGKAFRWGS

ZNF331

326

Q9NQX6
KYCADCEAKGPRWAS

SMAP1

31

Q8IYB5
PYKCEICGKRFSWRS

ZNF234

651

Q14588
RPYNCKECGKSFGWA

ZNF221

476

Q9UK13
CEECGKAYKWPSTLS

ZNF208

371

O43345
EKPYVCKDCGRGFTW

ZNF875

326

P10072
RPHKCEECGKAFGWS

ZNF732

416

B4DXR9
CKKSCIASRDPYCGW

SEMA6D

521

Q8NFY4