Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionzinc ion binding

ZNF385D ZFAND3 SETDB2 RARA RARB MID2 MBD1 MID1 TRIM49D1 ADAM33 NR1D1 ZFYVE1 TRIM48

1.88e-068916013GO:0008270
GeneOntologyMolecularFunctiontransition metal ion binding

ZNF385D ZFAND3 SETDB2 RARA RARB MID2 MBD1 MID1 TRIM49D1 FAXDC2 ADAM33 NR1D1 ZFYVE1 TRIM48

8.56e-0611896014GO:0046914
GeneOntologyMolecularFunctionlaminin binding

NTN4 ITGA7 AGRN

1.44e-0434603GO:0043236
GeneOntologyMolecularFunctioncytoskeletal protein binding

RARA MID2 NDC80 TRPM7 TTLL9 MID1 TUBGCP3 MACF1 PLEKHH2 FXYD1 MYO16

3.81e-0410996011GO:0008092
GeneOntologyMolecularFunctionnuclear receptor activity

RARA RARB NR1D1

7.81e-0460603GO:0004879
GeneOntologyMolecularFunctionligand-activated transcription factor activity

RARA RARB NR1D1

8.20e-0461603GO:0098531
GeneOntologyMolecularFunctionmicrotubule minus-end binding

TUBGCP3 MACF1

9.09e-0415602GO:0051011
GeneOntologyMolecularFunctionextracellular matrix binding

NTN4 ITGA7 AGRN

1.38e-0373603GO:0050840
DomainSEA

TMPRSS15 UMODL1 AGRN

4.20e-0522583PF01390
DomainSEA

TMPRSS15 UMODL1 AGRN

4.82e-0523583PS50024
DomainSEA_dom

TMPRSS15 UMODL1 AGRN

4.82e-0523583IPR000082
DomainRetinoic_acid_rcpt

RARA RARB

5.66e-054582IPR003078
DomainBBOX

MID2 MID1 TRIM49D1 TRIM48

6.23e-0569584SM00336
DomainButyrophylin

MID2 MID1 TRIM49D1 TRIM48

6.59e-0570584IPR003879
Domain-

MID2 MID1 TRIM49D1 TRIM48

6.97e-05715844.10.45.10
Domainzf-B_box

MID2 MID1 TRIM49D1 TRIM48

7.36e-0572584PF00643
DomainZF_BBOX

MID2 MID1 TRIM49D1 TRIM48

1.11e-0480584PS50119
DomainZnf_B-box

MID2 MID1 TRIM49D1 TRIM48

1.17e-0481584IPR000315
DomainEGF-like_CS

NTN4 CLEC18B UMODL1 ADAM33 AGRN EPHA1

1.55e-04261586IPR013032
DomainSPRY

MID2 MID1 TRIM49D1 TRIM48

2.07e-0494584PF00622
DomainSPRY_dom

MID2 MID1 TRIM49D1 TRIM48

2.07e-0494584IPR003877
DomainB30.2/SPRY

MID2 MID1 TRIM49D1 TRIM48

2.16e-0495584IPR001870
DomainB302_SPRY

MID2 MID1 TRIM49D1 TRIM48

2.16e-0495584PS50188
Domain-

SETDB2 MBD1

2.62e-0485823.30.890.10
Domainzf-C4

RARA RARB NR1D1

3.92e-0446583PF00105
DomainZnf_hrmn_rcpt

RARA RARB NR1D1

3.92e-0446583IPR001628
DomainNuclear_hrmn_rcpt

RARA RARB NR1D1

3.92e-0446583IPR001723
DomainNUCLEAR_REC_DBD_2

RARA RARB NR1D1

3.92e-0446583PS51030
DomainNUCLEAR_REC_DBD_1

RARA RARB NR1D1

3.92e-0446583PS00031
DomainZnF_C4

RARA RARB NR1D1

3.92e-0446583SM00399
Domain-

RARA RARB NR1D1

4.18e-04475831.10.565.10
DomainHOLI

RARA RARB NR1D1

4.45e-0448583SM00430
DomainNucl_hrmn_rcpt_lig-bd

RARA RARB NR1D1

4.45e-0448583IPR000536
DomainHormone_recep

RARA RARB NR1D1

4.45e-0448583PF00104
DomainMethyl_CpG_DNA-bd

SETDB2 MBD1

5.12e-0411582IPR001739
DomainMBD

SETDB2 MBD1

5.12e-0411582PF01429
DomainDNA-bd_dom

SETDB2 MBD1

5.12e-0411582IPR016177
DomainMBD

SETDB2 MBD1

5.12e-0411582SM00391
DomainMBD

SETDB2 MBD1

5.12e-0411582PS50982
DomainConA-like_dom

TMPRSS15 MID2 MID1 TRIM49D1 AGRN

5.85e-04219585IPR013320
DomainCOS_domain

MID2 MID1

6.13e-0412582IPR017903
DomainCOS

MID2 MID1

6.13e-0412582PS51262
Domain-

RARA RARB NR1D1

7.38e-04575833.30.50.10
DomainZnf_NHR/GATA

RARA RARB NR1D1

7.77e-0458583IPR013088
DomainSEA

TMPRSS15 AGRN

8.42e-0414582SM00200
DomainBbox_C

MID2 MID1

9.70e-0415582IPR003649
DomainBBC

MID2 MID1

9.70e-0415582SM00502
Domain-

GLIPR1 CLEC18B

9.70e-04155823.40.33.10
DomainCAP

GLIPR1 CLEC18B

9.70e-0415582PF00188
DomainCAP_domain

GLIPR1 CLEC18B

9.70e-0415582IPR014044
Domain-

TMPRSS15 AGRN

9.70e-04155823.30.70.960
DomainSCP

GLIPR1 CLEC18B

9.70e-0415582SM00198
DomainAllrgn_V5/Tpx1

GLIPR1 CLEC18B

9.70e-0415582IPR001283
DomainEGF_1

NTN4 CLEC18B UMODL1 ADAM33 AGRN

1.16e-03255585PS00022
DomainEGF_2

CLEC18B UMODL1 ADAM33 AGRN EPHA1

1.37e-03265585PS01186
DomainIntegrin_alpha-2

ITGA11 ITGA7

1.40e-0318582IPR013649
DomainIntegrin_alpha2

ITGA11 ITGA7

1.40e-0318582PF08441
DomainIntegrin_alpha

ITGA11 ITGA7

1.40e-0318582IPR000413
DomainINTEGRIN_ALPHA

ITGA11 ITGA7

1.40e-0318582PS00242
DomainInt_alpha_beta-p

ITGA11 ITGA7

1.57e-0319582IPR013519
DomainInt_alpha

ITGA11 ITGA7

1.57e-0319582SM00191
Domainfn3

MID2 UMODL1 MID1 EPHA1

1.61e-03162584PF00041
DomainFG_GAP

ITGA11 ITGA7

2.10e-0322582PS51470
DomainZF_RING_2

MID2 MID1 TRIM49D1 TTC3 TRIM48

2.30e-03298585PS50089
DomainNACHT

NLRP12 NAIP

2.30e-0323582PS50837
DomainNACHT_NTPase

NLRP12 NAIP

2.30e-0323582IPR007111
DomainFG-GAP

ITGA11 ITGA7

2.50e-0324582PF01839
DomainFG-GAP

ITGA11 ITGA7

2.50e-0324582IPR013517
DomainSPRY

MID2 MID1 TRIM49D1

2.50e-0387583SM00449
DomainRING

MID2 MID1 TRIM49D1 TTC3 TRIM48

2.54e-03305585SM00184
DomainFN3

MID2 UMODL1 MID1 EPHA1

2.61e-03185584SM00060
Domain-

MID2 MID1 TRIM49D1 TTC3 ZFYVE1 TRIM48

2.63e-034495863.30.40.10
DomainIntegrin_dom

ITGA11 ITGA7

2.72e-0325582IPR032695
DomainZnf_RING/FYVE/PHD

MID2 MID1 TRIM49D1 TTC3 ZFYVE1 TRIM48

2.93e-03459586IPR013083
DomainTIMP-like_OB-fold

NTN4 AGRN

2.94e-0326582IPR008993
DomainGalactose-bd-like

NTN4 SUN5 EPHA1

3.12e-0394583IPR008979
Pubmed

Recurrent RARB Translocations in Acute Promyelocytic Leukemia Lacking RARA Translocation.

RARA RARB

2.93e-06260229921692
Pubmed

Biological functional annotation of retinoic acid alpha and beta in mouse liver based on genome-wide binding.

RARA RARB

2.93e-06260224833708
Pubmed

Purification and crystallization of the heterodimeric complex of RARbeta and RXRalpha ligand-binding domains in the active conformation.

RARA RARB

2.93e-06260215159591
Pubmed

[The significance of expression of isoforms RARa1 and RARa2 in response to medicinal therapy and in evaluation of total survival of patients with primarily detected multiple myeloma].

RARA RARB

2.93e-06260230601638
Pubmed

Mid1/Mid2 expression in craniofacial development and a literature review of X-linked opitz syndrome.

MID2 MID1

2.93e-06260226788540
Pubmed

Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.

RARA RARB

2.93e-0626027644503
Pubmed

Retinoic acid receptors in normal growth and development.

RARA RARB

2.93e-0626021330302
Pubmed

Association between nuclear expression of retinoic acid receptor alpha and beta and clinicopathological features and prognosis of advanced non-small cell lung cancer.

RARA RARB

2.93e-06260227306217
Pubmed

Compartment-selective sensitivity of cardiovascular morphogenesis to combinations of retinoic acid receptor gene mutations.

RARA RARB

2.93e-0626029168777
Pubmed

Anticancer effect of retinoic acid via AP-1 activity repression is mediated by retinoic acid receptor alpha and beta in gastric cancer cells.

RARA RARB

2.93e-06260212009305
Pubmed

Retinoic acid regulates gene expression of retinoic acid receptors alpha, beta and gamma in F9 mouse teratocarcinoma cells.

RARA RARB

2.93e-0626021334013
Pubmed

Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma.

RARA RARB

8.77e-0636029852056
Pubmed

Differential expression of retinoic acid receptors in normal and malignant esophageal tissues.

RARA RARB

8.77e-06360215255287
Pubmed

Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants.

RARA RARB

8.77e-0636027607068
Pubmed

Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants.

RARA RARB

8.77e-0636027607067
Pubmed

Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia.

RARA RARB

8.77e-06360217244680
Pubmed

Impaired distribution of retinoic acid receptors in the hindgut-tailgut region of murine embryos with anorectal malformations.

RARA RARB

8.77e-06360211172439
Pubmed

Cloning of several genes coding for retinoic acid nuclear receptors in the mouse embryonal carcinoma cell line PCC7-MZ1.

RARA RARB

8.77e-0636028383767
Pubmed

The molecular and genetic dissection of the retinoid signalling pathway.

RARA RARB

8.77e-0636028276261
Pubmed

Retinoic acid receptor gamma: specific immunodetection and phosphorylation.

RARA RARB

8.77e-0636021655807
Pubmed

Requirement of retinoic acid receptor isotypes alpha, beta, and gamma during the initial steps of neural differentiation of PCC7 cells.

RARA RARB

8.77e-06360215831518
Pubmed

A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia.

RARA RARB

8.77e-06360217252005
Pubmed

Immunolocalization of retinoic acid receptors in rat, mouse and human ovary and uterus.

RARA RARB

8.77e-0636028136307
Pubmed

Retinoic acid down-regulation of fibronectin and retinoic acid receptor alpha proteins in NIH-3T3 cells. Blocks of this response by ras transformation.

RARA RARB

8.77e-0636028626453
Pubmed

Genes involved in cell adhesion and signaling: a new repertoire of retinoic acid receptor target genes in mouse embryonic fibroblasts.

RARA RARB

8.77e-06360224357724
Pubmed

Function of retinoic acid receptor gamma in the mouse.

RARA RARB

8.77e-0636028388780
Pubmed

Contribution of retinoic acid receptor beta isoforms to the formation of the conotruncal septum of the embryonic heart.

RARA RARB

8.77e-0636029659935
Pubmed

Retinoids and vertebrate development.

RARA RARB

8.77e-0636027910825
Pubmed

Tissue-specific expression of retinoic acid receptor isoform transcripts in the mouse embryo.

RARA RARB

8.77e-06360210842077
Pubmed

Retinoic acid and mouse skin morphogenesis. I. Expression pattern of retinoic acid receptor genes during hair vibrissa follicle, plantar, and nasal gland development.

RARA RARB

8.77e-0636028027572
Pubmed

MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders.

MID2 MID1

8.77e-06360211806752
Pubmed

Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity.

RARA RARB

8.77e-06360211245412
Pubmed

mRNA expression pattern of retinoic acid and retinoid X nuclear receptor subtypes in human thyroid papillary carcinoma.

RARA RARB

8.77e-06360223969901
Pubmed

Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin.

RARA RARB

8.77e-0636022544807
Pubmed

[Genetic expression and morphogenesis of the skin in vertebrates].

RARA RARB

8.77e-0636028099268
Pubmed

Regulation of retinoic acid receptor alpha by protein kinase C in B16 mouse melanoma cells.

RARA RARB

8.77e-06360212000751
Pubmed

Altered expression of retinoic acid (RA) receptor mRNAs in the fetal mouse secondary palate by all-trans and 13-cis RAs: implications for RA-induced teratogenesis.

RARA RARB

8.77e-06360210100049
Pubmed

Specificity of retinoid receptor gene expression in mouse cervical epithelia.

RARA RARB

8.77e-0636028156902
Pubmed

Both retinoic acid receptors alpha (RARalpha) and gamma (RARgamma) are able to initiate mouse upper-lip skin glandular metaplasia.

RARA RARB

8.77e-0636029699718
Pubmed

Mammalian hexokinase 1: evolutionary conservation and structure to function analysis.

RARA RARB

8.77e-0636021783373
Pubmed

Retinoic acid receptor-beta: immunodetection and phosphorylation on tyrosine residues.

RARA RARB

8.77e-0636021283441
Pubmed

Characterization of retinoic acid receptor-deficient keratinocytes.

RARA RARB

8.77e-06360210748128
Pubmed

Synergistic activation of RARβ and RARγ nuclear receptors restores cell specialization during stem cell differentiation by hijacking RARα-controlled programs.

RARA RARB

8.77e-06360236446525
Pubmed

Strain difference and mode of inheritance of the susceptibility to passive cutaneous anaphylaxis mediated by allogeneic IgE antibody in the mouse.

RARA RARB

8.77e-0636022737701
Pubmed

Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.

RARA RARB

8.77e-06360215528208
Pubmed

Immunohistochemical localization of the retinoic Acid receptors in human prostate.

RARA RARB

8.77e-06360212399530
Pubmed

Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells.

RARA RARB

8.77e-06360229848550
Pubmed

Association of retinoic acid receptor genes with meningomyelocele.

RARA RARB

8.77e-06360221254357
Pubmed

Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes.

RARA RARB

8.77e-0636021655630
Pubmed

HACE1: A novel repressor of RAR transcriptional activity.

RARA RARB

1.75e-05460219350571
Pubmed

Association of peroxisome proliferator-activated receptors/retinoic acid receptors with renal diseases.

RARA RARB

1.75e-05460224050824
Pubmed

Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled.

RARA RARB

1.75e-05460212093741
Pubmed

Roles of retinoic acid receptors and of Hox genes in the patterning of the teeth and of the jaw skeleton.

RARA RARB

1.75e-0546027626396
Pubmed

Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand.

RARA RARB

1.75e-0546028524212
Pubmed

Immunolocalization of enzymes, binding proteins, and receptors sufficient for retinoic acid synthesis and signaling during the hair cycle.

RARA RARB

1.75e-05460217363914
Pubmed

Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma.

RARA RARB

1.75e-05460222022577
Pubmed

The retinoid receptors.

RARA RARB

1.75e-0546027967725
Pubmed

MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation.

MID2 MID1

1.75e-05460211685209
Pubmed

Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells.

RARA RARB

1.75e-0546029005841
Pubmed

Identification of a retinoid receptor response element in the human aldehyde dehydrogenase-2 promoter.

RARA RARB

1.75e-05460214691372
Pubmed

Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters.

RARA RARB

1.75e-05460218845237
Pubmed

The retinoic acid receptors RARalpha and RARgamma are required for inner ear development.

RARA RARB

1.75e-05460212464434
Pubmed

Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms.

RARA RARB

1.75e-0546029376317
Pubmed

Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression.

RARA RARB

1.75e-05460223102699
Pubmed

Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells.

RARA RARB

1.75e-0546029348290
Pubmed

Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse.

RARA RARB

1.75e-0546022556642
Pubmed

Retinoic acid signalling in the development of branchial arches.

RARA RARB

1.75e-05460215380252
Pubmed

Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway.

RARA RARB

1.75e-05460210869350
Pubmed

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

ZNF385D ITGA11 FRY RARB UMODL1

2.47e-0519960523382691
Pubmed

Retinoic acid signaling regulates murine bronchial tubule formation.

RARA RARB

2.92e-05560212834868
Pubmed

Retinoic acid signaling is necessary for the development of the organ of Corti.

RARA RARB

2.92e-05560210452855
Pubmed

An essential set of basic DNA response elements is required for receptor-dependent transcription of the lecithin:retinol acyltransferase (Lrat) gene.

RARA RARB

2.92e-05560219665987
Pubmed

Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity.

RARA RARB

2.92e-05560231097581
Pubmed

Regulation of the Oct-4 gene by nuclear receptors.

RARA RARB

2.92e-0556028152920
Pubmed

The methyl-CpG binding protein MBD1 is required for PML-RARalpha function.

RARA MBD1

2.92e-05560216432238
Pubmed

Retinoic acid receptor beta 2 mRNA is elevated by retinoic acid in vivo in susceptible regions of mid-gestation mouse embryos.

RARA RARB

2.92e-0556021334737
Pubmed

Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development.

RARA RARB

2.92e-0556029053308
Pubmed

Vitamin A controls epithelial/mesenchymal interactions through Ret expression.

RARA RARB

2.92e-05560211138002
Pubmed

High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.

RARA RARB

2.92e-0556028394014
Pubmed

Initiation of retinoid signaling in primitive streak mouse embryos: spatiotemporal expression patterns of receptors and metabolic enzymes for ligand synthesis.

RARA RARB

2.92e-0556029097025
Pubmed

Retinal dysplasia and degeneration in RARbeta2/RARgamma2 compound mutant mice.

RARA RARB

2.92e-0556028681798
Pubmed

Changes of the expression and distribution of retinoic acid receptors during neurogenesis in mouse embryos.

RARA RARB

2.92e-0556028174226
Pubmed

Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.

RARA RARB

2.92e-05560219006694
Pubmed

ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.

RARA RARB

2.92e-05560219345331
Pubmed

Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret.

RARA RARB

2.92e-05560212195422
Pubmed

The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development.

RARA RARB

4.37e-0566029806918
Pubmed

Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis.

RARA RARB

4.37e-0566021966045
Pubmed

Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes.

RARA RARB

4.37e-05660211328745
Pubmed

Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding.

MID2 MID1

4.37e-05660216434393
Pubmed

A genetic dissection of the retinoid signalling pathway in the mouse.

RARA RARB

4.37e-05660210604193
Pubmed

Retinoid signaling and the generation of regional and cellular diversity in the embryonic mouse spinal cord.

RARA RARB

4.37e-0566028563020
Pubmed

Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos.

RARA RARB

4.37e-0566021849812
Pubmed

The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains.

RARA RARB

4.37e-0566029153406
Pubmed

Retinoid signaling distinguishes a subpopulation of olfactory receptor neurons in the developing and adult mouse.

RARA RARB

4.37e-0566029590554
Pubmed

Dysregulated endocardial TGFβ signaling and mesenchymal transformation result in heart outflow tract septation failure.

RARA RARB

4.37e-05660226522286
Pubmed

DLG1 influences distal ureter maturation via a non-epithelial cell autonomous mechanism involving reduced retinoic acid signaling, Ret expression, and apoptosis.

RARA RARB

4.37e-05660224699546
Pubmed

Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning.

RARA RARB

4.37e-05660211493525
Pubmed

Mesenchymal/epithelial regulation of retinoic acid signaling in the olfactory placode.

RARA RARB

4.37e-05660212941622
Pubmed

Isolation of genes differentially expressed in human primary myoblasts and embryonal rhabdomyosarcoma.

NTN4 ITGA11

4.37e-0566028635876
Pubmed

Spatial distributions of retinoic acid receptor gene transcripts in the prenatal mouse inner ear.

RARA RARB

4.37e-0566029548551
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

MID2 MID1 TRIM49D1 TRIM48

9.04e-059545459
GeneFamilyNuclear hormone receptors

RARA RARB NR1D1

2.45e-044945371
GeneFamilyZinc fingers CXXC-type|Methyl-CpG binding domain containing

SETDB2 MBD1

3.28e-04114521025
GeneFamilyRing finger proteins

MID2 MID1 TRIM49D1 TTC3 TRIM48

5.83e-0427545558
GeneFamilyCD molecules|Integrin alpha subunits

ITGA11 ITGA7

9.04e-04184521160
GeneFamilyNLR family

NLRP12 NAIP

1.75e-0325452666
GeneFamilyFibronectin type III domain containing

MID2 MID1 EPHA1

7.35e-03160453555
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

ZNF385D TMPRSS15 ADAM33 ITGA7 FXYD1

2.49e-06160605d783d29150033e9181c0e30870070268fed3fd85
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

ZNF385D NLRP12 DGKI ADAM33 ITGA7

4.68e-06182605ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

NTN4 CXCL17 ARHGEF38 ACSS2 TMC5

4.93e-06184605369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

GALNT15 ZNF385D ITGA11 ADAM33 PLEKHH2

5.06e-06185605fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

NTN4 ITGA11 CLEC18B ADAM33 ITGA7

5.33e-061876051aebf6fab40b96f2f5feb77a302bb805838fccf3
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF385D NTN4 ADRA1A ADAM33 ITGA7

5.33e-0618760502105c82a9ba79d2f19e002188377fc3440770c2
ToppCellCOVID-19-lung-AT2|COVID-19 / Disease (COVID-19 only), tissue and cell type

NTN4 CXCL17 ARHGEF38 ACSS2 TMC5

5.76e-0619060527a1a86620fe9b5ee930d388b32352206485e6d0
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NTN4 ITGA11 FRY ADAM33 ITGA7

5.76e-06190605d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCellmLN-T_cell-Th17|T_cell / Region, Cell class and subclass

GLIPR1 ZNF385D NTN4 NLRP12 MYO16

7.04e-06198605efdc9515dd9fb20ef9c8ddc106d88cbdde7d6ea2
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MID1 MACF1 PLEKHH2 AGRN IQUB

7.22e-061996053cd6383c50ce342fe5c175e2e50784d634a90e80
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

ZNF385D FRY DGKI PLEKHH2 MYO16

7.39e-06200605f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

ZNF385D FRY DGKI PLEKHH2 MYO16

7.39e-06200605cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-MC4R|Neuronal / cells hierarchy compared to all cells using T-Statistic

ZNF385D NTN4 ADRA1A ADAM33 ITGA7

7.39e-06200605c1797542541747b524c9c22c723d24c8d027d486
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

ZNF385D FRY DGKI PLEKHH2 MYO16

7.39e-06200605c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

ZNF385D FRY DGKI PLEKHH2 MYO16

7.39e-062006054fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

ZNF385D FRY DGKI PLEKHH2 MYO16

7.39e-06200605310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-MC4R-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

ZNF385D NTN4 ADRA1A ADAM33 ITGA7

7.39e-06200605a0cc84add181109bb66ba9d49c732e1790222c96
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

ZNF385D FRY DGKI PLEKHH2 MYO16

7.39e-06200605961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-2|TCGA-Bladder / Sample_Type by Project: Shred V9

ZNF385D ADAM33 ITGA7 FXYD1

2.38e-05124604ff08f74c3bc8e60679e0e21370095936a174c580
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TMPRSS15 ADRA1A PLEKHH2 MYO16

2.45e-05125604b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCell(02)_Cycling_Basal_(regeneration)-(3)_72hpi|(02)_Cycling_Basal_(regeneration) / shred by cell type and Timepoint

CROCC2 CXCL17 ACSS2 TMC5

3.13e-0513360432c6a00671af309c4b0b90e93549733729684c61
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-AT1_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ITGA11 ZNF425 CXCL17 IQUB

4.39e-05145604186b8bd8ac2d5c66cc29fdc2dd6751eddce3e8b8
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF385D RARB NDC80 AGRN

5.98e-05157604beab0ac47202266b04543c02cfcdda012375e879
ToppCellIIF-Lymphocyte-T_NK-ILC|IIF / Disease, Lineage and Cell Type

ADRA1A TTLL9 TUBGCP3 ZFYVE1

6.28e-0515960455e4f21548f480ca414c00cbff5ec3b13bafd271
ToppCellURO-Lymphocyte-T_NK-MAIT|URO / Disease, Lineage and Cell Type

NTN4 TTLL9 ZNF425 EPHA1

7.08e-05164604cb42a70433b3968caca67f7aa98ea536cd90a0bc
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

GALNT15 ZNF385D PLEKHH2 ADGRL2

7.42e-05166604f416d8a322f086c769659a9fab6b460a2d546ab1
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TTLL9 CROCC2 LMLN IQUB

7.95e-05169604fba841664939c771881ba97f14ef1df6635c04ff
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 FRY ADRA1A TMC5

8.13e-0517060499dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 FRY ADRA1A TMC5

8.13e-051706043a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 FRY ADRA1A TMC5

8.13e-05170604cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCellPericytes-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

ITGA11 DGKI ADAM33 ITGA7

8.32e-05171604bbc8d9fc83d37c9250345b1e76776610799de9ae
ToppCell3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GALNT15 ITGA11 ADAM33 FXYD1

8.70e-0517360411e95a60b5f6f07f27154a23203bac431e7528c6
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue-3|TCGA-Breast / Sample_Type by Project: Shred V9

ADRA1A ADAM33 ITGA7 FXYD1

8.90e-051746047f8f5fafae08676d2b90cab9802c3c9320f1370e
ToppCellTCGA-Breast-Solid_Tissue_Normal|TCGA-Breast / Sample_Type by Project: Shred V9

ADRA1A ADAM33 ITGA7 FXYD1

8.90e-05174604e2f240d60bffbe8e6d60f0bb405b231bd3c96875
ToppCellP15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RIMKLA MACF1 FXYD1 EPHA1

8.90e-051746043c47d069bd836599a8d40eae485c23d4d3487517
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue|TCGA-Breast / Sample_Type by Project: Shred V9

ADRA1A ADAM33 ITGA7 FXYD1

8.90e-051746040f3ec0d0d4344e10c9b48adc9174123f6402dc51
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NTN4 ITGA11 FRY ITGA7

8.90e-05174604015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue|TCGA-Breast / Sample_Type by Project: Shred V9

ADRA1A ADAM33 ITGA7 FXYD1

8.90e-051746041aadbf2642b6d1320ceabd92e6ff59e11f16c315
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GALNT15 MACF1 ADAM33 PLEKHH2

9.10e-051756041799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NTN4 FRY ADRA1A ITGA7

9.30e-0517660490f36f10c6ed440a0ca549f23219398853f1fbc3
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF385D NTN4 RARB MYO16

9.51e-0517760491706bd0d4dda8d98843fb00b898d5aca4d66b64
ToppCellPericytes-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

ITGA11 RARB ITGA7 FXYD1

9.72e-05178604a2448d868da2abe48c394c51264aad03e866dfec
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADRA1A PLEKHH2 FXYD1 MYO16

1.01e-041806049b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCellHippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Adcyap1_(Dentate_hilum?)|Hippocampus / BrainAtlas - Mouse McCarroll V32

GLIPR1 NLRP12 TMPRSS15

1.02e-046760352f6c244e8d89ccacb79bc5ef3663a5d01fd393c
ToppCellHippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Adcyap1_(Dentate_hilum?)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

GLIPR1 NLRP12 TMPRSS15

1.02e-0467603e462f9b5dca7c64101a31891f25654c05f2d215d
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADRA1A PLEKHH2 FXYD1 MYO16

1.04e-041816049e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF385D NTN4 RARB MYO16

1.04e-04181604bd7e9437839bca543ca5945df43d6525e6a312a8
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GALNT15 ZNF385D ADAM33 PLEKHH2

1.04e-04181604b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF385D NTN4 ADRA1A ADAM33

1.04e-041816042f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGA11 ADAM33 ITGA7 FXYD1

1.08e-04183604b4f29dd3994009bb5eb769d36d95886664e7f87d
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-6_RORB_HPCA|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NTN4 RARB PLEKHH2 ADGRL2

1.08e-04183604c7e94fe3e7669db9304b249979fef7a69c30a143
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF385D NTN4 ADRA1A ADAM33

1.08e-041836046e6128c5be5e0a2db6d84eecbf4dddd02d0216f8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF385D NTN4 ADRA1A ADAM33

1.08e-04183604e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF385D NTN4 ADRA1A ADAM33

1.08e-041836045e361be3ae3fe05098968e58427630127bd12675
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF385D NTN4 ADRA1A ADAM33

1.13e-0418560416e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NTN4 RARB CXCL17 TUBGCP3

1.13e-04185604ef3c1fd52d21d96f81fb0e5097b24be0ce16e222
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

NTN4 ARHGEF38 ACSS2 TMC5

1.13e-04185604cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF385D NTN4 ADRA1A ADAM33

1.13e-0418560408fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NTN4 RARB CXCL17 TUBGCP3

1.13e-04185604c357fa098b561da16c9fa82b0c3563b5cd3fa875
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NTN4 ADRA1A ADAM33 TMC5

1.13e-041856044c42bd3cd72f91f4d4ebb849069a03761a2cd662
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LMLN NAIP PLEKHH2 FXYD1

1.15e-0418660477bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LMLN NAIP PLEKHH2 FXYD1

1.15e-0418660413bc41c60fd628af31899a5e8b480e06cc4781be
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GLIPR1 ZNF385D NTN4 MYO16

1.15e-041866046379609b7ace80683f5754b16aa77f11b43766ae
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|368C / Donor, Lineage, Cell class and subclass (all cells)

CXCL17 LMLN TMC5 AGRN

1.17e-04187604b827d9da7032bf051756ddf88352af922eb0f87b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRY MID1 MYO16 IQUB

1.17e-04187604f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|368C / Donor, Lineage, Cell class and subclass (all cells)

CXCL17 LMLN TMC5 AGRN

1.17e-0418760461c00604dda8b36a5c3eea6554e5601aa1b884f7
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 ADRA1A ADAM33 ITGA7

1.20e-04188604b2d68a32314e9b099ed74d974079ad96359d1ae3
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 FRY PLEKHH2 AGRN

1.20e-04188604b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellCOPD-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

FRY NAIP FAXDC2 ADGRL2

1.20e-041886041aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCellCOVID-19-kidney-DCT|kidney / Disease (COVID-19 only), tissue and cell type

ZNF385D TRPM7 ARHGEF38 ADGRL2

1.20e-04188604df1fd0819d301679f3c9ea404e942e39095912eb
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF385D NTN4 RARB MYO16

1.20e-0418860472cbfe9dc0583dbeafa6cb0945fa370d0c808284
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 FRY PLEKHH2 AGRN

1.20e-04188604874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

CXCL17 ARHGEF38 ACSS2 TMC5

1.20e-04188604ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRY ADRA1A ITGA7 FXYD1

1.22e-04189604032f169e8ede653117919bf97c17f92043320b3c
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADRA1A PLEKHH2 FXYD1 MYO16

1.22e-04189604e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCellfacs-Skin-nan-18m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM33 FXYD1 MYO16 IL19

1.22e-0418960429287525120be2953b76881ba3cfc4379c265e7a
ToppCellfacs-Skin-nan-18m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM33 FXYD1 MYO16 IL19

1.22e-041896047150dad9a92a715487c2d8130fa01b752ea69663
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRY ADRA1A ITGA7 FXYD1

1.22e-0418960407208d32afca6f93207a2ac35b647b31a9f71b7c
ToppCellfacs-Skin-nan-18m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM33 FXYD1 MYO16 IL19

1.22e-041896046e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRY ADRA1A ADAM33 ITGA7

1.22e-04189604127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

ZNF385D FRY MID1 MACF1

1.22e-041896046b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GLIPR1 ZNF385D NTN4 MYO16

1.22e-0418960499a13b1b669b0cd36e3096632351d9ade25d1173
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRY ADRA1A ADAM33 ITGA7

1.22e-041896042cfb4d12f75678d1619f4743838a0e954bd57761
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADRA1A RARB PLEKHH2 MYO16

1.25e-0419060445df8fee00f8949937863159d7aa042e72748d9b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRY MID1 ARHGEF38 IQUB

1.25e-041906044836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 FRY ADRA1A ITGA7

1.25e-0419060470c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GLIPR1 ZNF385D NTN4 MYO16

1.25e-041906048c9c230a509afaeee50644153974a5642b01a2b8
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAM33 PLEKHH2 FXYD1 MYO16

1.27e-0419160414057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF385D ADAM33 ITGA7 FXYD1

1.27e-0419160408042952431ca1a6fd7dfc13f36eb28643979598
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FRY ARHGEF38 FAXDC2 DGKI

1.27e-0419160454f07e4de61735051498846afb44b1798bed8144
ToppCellMesenchymal-vascular_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

ITGA11 FRY ADAM33 ITGA7

1.27e-04191604fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 FRY RARB ITGA7

1.27e-041916047b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF385D NTN4 ADRA1A MYO16

1.27e-04191604fa50a3c7ff86e1ee07100da1ace0b0fa1b0ab26b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MID1 ADGRL2 MYO16 IQUB

1.27e-0419160496b78b4e819ea6052334bfcbc7abbf35897df885
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTLL9 CROCC2 CXCL17 IQUB

1.27e-0419160496483adb97c81208aa513782550acd8a08b63866
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 FRY RARB ITGA7

1.27e-04191604cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADRA1A PLEKHH2 FXYD1 MYO16

1.30e-041926046f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCellCOVID-19-kidney-CNT|kidney / Disease (COVID-19 only), tissue and cell type

ZNF385D MID1 ARHGEF38 IQUB

1.30e-04192604d32ae226d95b4b6adb99d14b602be09b661d4cd9
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADRA1A PLEKHH2 FXYD1 MYO16

1.30e-04192604f4fc2b0121f879bab2bee99dfb5ff2c3ca1c0e1b
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADRA1A RARB MID1 MYO16

1.30e-04192604df1545670370fb1010c567cd059c2783eab315f7
DrugRo 8-8717

RARA RARB

6.60e-062592CID006438148
DrugTamibarotene

RARA RARB

6.60e-062592DB04942
DrugPenbutolol sulfate [38363-32-5]; Up 200; 5.8uM; MCF7; HT_HG-U133A

GLIPR1 RIN1 ADRA1A RARA FAXDC2 ITGA7

1.06e-051935963534_UP
DrugKawain [500-64-1]; Down 200; 17.4uM; PC3; HT_HG-U133A

ZNF385D ZFAND3 RARA MBD1 TMC5 ZNF292

1.16e-051965967369_DN
DiseaseNeuralgia-Neuritis, Sciatic Nerve

RARA RARB

2.19e-054572C0751924
DiseaseSciatic Nerve Palsy

RARA RARB

2.19e-054572C0751925
DiseaseLesion of Sciatic Nerve

RARA RARB

2.19e-054572C0154748
DiseaseSciatic Neuritis

RARA RARB

2.19e-054572C0242013
DiseaseSciatic Neuropathy

RARA RARB

2.19e-054572C0149940
DiseaseOpitz GBBB syndrome (implicated_via_orthology)

MID2 MID1

5.47e-056572DOID:0080697 (implicated_via_orthology)
Diseaseubiquitin-like protein ISG15 measurement

NLRP12 AGRN

5.47e-056572EFO_0021875
Diseasesusceptibility to common cold measurement

RARB ARHGEF38 MYO16

1.58e-0454573EFO_0008417
Diseasecup-to-disc ratio measurement

RARB CLEC18B ASB7 CROCC2 MYO16 SYMPK

1.79e-04430576EFO_0006939
DiseaseFEV change measurement, response to bronchodilator

GALNT15 MBD1 ADGRL2

1.96e-0458573EFO_0005921, GO_0097366
Diseasetuberculin skin test reactivity measurement, decreased susceptibility to bacterial infection

FRY ZFYVE1

2.39e-0412572EFO_0008307, EFO_0008322
Diseasecaudal anterior cingulate cortex volume measurement

ZNF385D TMPRSS15

4.89e-0417572EFO_0010289
Diseasemaximal midexpiratory flow rate

GALNT15 MYO16

6.81e-0420572EFO_0004313
Diseaseeconomic and social preference

MBD1 ARHGEF38 IL19

8.86e-0497573EFO_0004827
Diseasereaction time measurement

GALNT15 ADRA1A FAXDC2 DGKI ADGRL2 TRIM48

1.66e-03658576EFO_0008393

Protein segments in the cluster

PeptideGeneStartEntry
ATCKINCNNFRLLQN

UMODL1

1226

Q5DID0
RKQIISCNICQLRFN

ZNF385D

76

Q9H6B1
IQQCQQLHCLRVLSF

NAIP

1256

Q13075
AARNILVNQNLCCKV

EPHA1

751

P21709
RNLQDLCRIKIRQCI

ASB7

276

Q9H672
LCRIKIRQCIGLQNL

ASB7

281

Q9H672
AFQNVLRIQCLCRKQ

ADRA1A

336

P35348
NQAARKILLNCLCSF

ARHGEF38

481

Q9NXL2
CELQRAQCSQQRRIR

AGRN

221

O00468
KIMTQRCNNRTQCIV

ADGRL2

91

O95490
RCRKNAFQELQRCLT

ADAM33

641

Q9BZ11
LLVQVCQFSNVLRKQ

ACSS2

141

Q9NR19
IINKVTRNRCQYCRL

RARA

131

P10276
VINKVTRNRCQYCRL

RARB

131

P10826
CRLVNRPQSILNCIN

RIMKLA

96

Q8IXN7
QAQQVQRIISRCNCR

KIAA0100

1696

Q14667
CLDNLCVNRQRDQVK

GLIPR1

201

P48060
NDLCLQLQRKIITCQ

MYO16

1141

Q9Y6X6
KTLRQCQEQRQCHCR

IL19

116

Q9UHD0
QCLQDSLIRLQCNHK

TMPRSS15

756

P98073
CRQDQRAVAVCNLQK

LMLN

431

Q96KR4
CVLVSIRNNRNLQKF

FBXO33

191

Q7Z6M2
LCFAVRQEQVILQNC

GALNT15

561

Q8N3T1
NQKRQKCRWRQCLQF

MBD1

366

Q9UIS9
LSRRCRCKFNQQQRT

FXYD1

56

O00168
QKSPNVLLQNLCCRI

TUBGCP3

6

Q96CW5
CVNEERRLQKQVCNV

ITGA11

881

Q9UKX5
QIQSREVQRKAFCTC

OR2A7

226

Q96R45
LQNEICCQLIKQTRR

PLEKHH2

1016

Q8IVE3
CCQLIKQTRRRQPQN

PLEKHH2

1021

Q8IVE3
LLIRFLCCSQQQKAT

MAS1L

246

P35410
VTRQVAQCKCAKRFQ

MACF1

7126

Q9UPN3
KNENCSIVRINRNRC

NR1D1

171

P20393
SIVRINRNRCQQCRF

NR1D1

176

P20393
NRNRCQQCRFKKCLS

NR1D1

181

P20393
VKLRQSIRTVLFNQC

FAXDC2

126

Q96IV6
AQRLEVQQCRASCKL

CROCC2

471

H7BZ55
KAACQRNRAVCQLLV

DGKI

1001

O75912
RIYRCRNCINLQNEA

IQUB

621

Q8NA54
ICQSNLQLVRARFCT

ITGA7

686

Q13683
TCLLCVSQKQLFLNR

FRY

366

Q5TBA9
RACQQFLKQCQLRSF

CXCL17

101

Q6UXB2
TQCFECIKTIQQRNL

TRIM48

66

Q8IWZ4
FLVRKSNTRQCQALC

RIN1

91

Q13671
CAQRQLQLEQSLRVC

TEDC2

21

Q7L2K0
VQLLKRQSCPCQRND

NTN4

226

Q9HB63
INLLNNAIRLKFQNC

NUP160

121

Q12769
FIRNLCQKRHVCIQS

SRBD1

386

Q8N5C6
QRCKTRNRYICQFAQ

CLEC18B

431

Q6UXF7
SLLCKCNRQLCQNRV

SETDB2

346

Q96T68
RTQAQQVLFNTCRCK

SUN5

81

Q8TC36
RLRKLAQQIANCKQC

MID1

291

O15344
RNLLIVFKRCCNSQV

ZNF292

2421

O60281
QRCQFLDDRILQCIK

TTC3

811

P53804
CCQRTKPQSFQVILQ

SYMPK

1041

Q92797
QRAIVRCQTCKINLC

ZFYVE1

86

Q9HBF4
CVNDRKKQLRQLFCS

TTLL9

416

Q3SXZ7
QCFECLKTTQQRNLK

TRIM49D1

51

C9J1S8
SKQTHRILQLNCCIQ

TMC5

391

Q6UXY8
RILQLNCCIQCLNSI

TMC5

396

Q6UXY8
KLRKLAQQVANCRQC

MID2

311

Q9UJV3
NCRQCLERSTVLINQ

MID2

321

Q9UJV3
TQRLLCQKKRFQCSE

ZNF425

236

Q6IV72
RCFQCQTKLELVQQE

ZFAND3

156

Q9H8U3
CQQLVRCFCGRLVKQ

TRPM7

36

Q96QT4
NCKLQNLRLKRCRIS

NLRP12

741

P59046
LNDKAFIQQCIRQLC

NDC80

86

O14777