Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	adenylosuccinate synthase activity	ADSS2 ADSS1	1.11e-05	2	67	2	GO:0004019
GeneOntologyMolecularFunction	metalloendopeptidase activity	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	5.17e-05	120	67	5	GO:0004222
GeneOntologyMolecularFunction	cytidine kinase activity	UCK2 UCK1	6.63e-05	4	67	2	GO:0043771
GeneOntologyMolecularFunction	uridine kinase activity	UCK2 UCK1	6.63e-05	4	67	2	GO:0004849
GeneOntologyMolecularFunction	lipid transmembrane transporter activity	ABCA4 SLCO1C1 SLCO2A1 ABCB11	1.06e-04	73	67	4	GO:0170055
GeneOntologyMolecularFunction	nucleoside kinase activity	UCK2 UCK1	3.93e-04	9	67	2	GO:0019206
GeneOntologyMolecularFunction	lipid transporter activity	ABCA4 SLCO1C1 SLCO2A1 ABCB11 ABCB4	5.11e-04	196	67	5	GO:0005319
GeneOntologyMolecularFunction	metallopeptidase activity	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	5.60e-04	200	67	5	GO:0008237
GeneOntologyMolecularFunction	endopeptidase activity	ADAMTS12 PCSK5 ADAMTS2 ADAMTS1 ADAMTS20 TMPRSS2 ADAM22	5.84e-04	430	67	7	GO:0004175
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCA4 ABCB11 ABCB4	5.96e-04	49	67	3	GO:0140359
GeneOntologyMolecularFunction	ligase activity, forming carbon-nitrogen bonds	ASNSD1 ADSS2 ADSS1	7.50e-04	53	67	3	GO:0016879
GeneOntologyMolecularFunction	phosphate ion binding	ADSS2 ADSS1	1.29e-03	16	67	2	GO:0042301
GeneOntologyMolecularFunction	sodium-independent organic anion transmembrane transporter activity	SLCO1C1 SLCO2A1	1.64e-03	18	67	2	GO:0015347
GeneOntologyMolecularFunction	organic hydroxy compound transmembrane transporter activity	ABCA4 SLCO1C1 ABCB11	1.68e-03	70	67	3	GO:1901618
GeneOntologyBiologicalProcess	nucleotide salvage	ADSS2 UCK2 UCK1 ADSS1	1.53e-06	26	68	4	GO:0043173
GeneOntologyBiologicalProcess	ribonucleoside monophosphate biosynthetic process	ADSS2 UCK2 UCK1 ADSS1	7.33e-06	38	68	4	GO:0009156
GeneOntologyBiologicalProcess	cellular metabolic compound salvage	ADSS2 UCK2 UCK1 ADSS1	9.03e-06	40	68	4	GO:0043094
GeneOntologyBiologicalProcess	nucleoside monophosphate biosynthetic process	ADSS2 UCK2 UCK1 ADSS1	2.05e-05	49	68	4	GO:0009124
GeneOntologyBiologicalProcess	CTP salvage	UCK2 UCK1	3.21e-05	3	68	2	GO:0044211
GeneOntologyBiologicalProcess	CMP biosynthetic process	UCK2 UCK1	6.40e-05	4	68	2	GO:0009224
GeneOntologyBiologicalProcess	ribonucleoside monophosphate metabolic process	ADSS2 UCK2 UCK1 ADSS1	7.08e-05	67	68	4	GO:0009161
GeneOntologyBiologicalProcess	UMP salvage	UCK2 UCK1	1.59e-04	6	68	2	GO:0044206
GeneOntologyBiologicalProcess	pyrimidine nucleotide salvage	UCK2 UCK1	1.59e-04	6	68	2	GO:0032262
GeneOntologyBiologicalProcess	negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	UBR3 FBXO11	1.59e-04	6	68	2	GO:1904878
GeneOntologyBiologicalProcess	pyrimidine ribonucleotide salvage	UCK2 UCK1	1.59e-04	6	68	2	GO:0010138
GeneOntologyBiologicalProcess	nucleoside monophosphate metabolic process	ADSS2 UCK2 UCK1 ADSS1	2.05e-04	88	68	4	GO:0009123
GeneOntologyBiologicalProcess	pyrimidine-containing compound salvage	UCK2 UCK1	2.23e-04	7	68	2	GO:0008655
GeneOntologyBiologicalProcess	AMP salvage	ADSS2 ADSS1	2.96e-04	8	68	2	GO:0044209
GeneOntologyBiologicalProcess	'de novo' AMP biosynthetic process	ADSS2 ADSS1	2.96e-04	8	68	2	GO:0044208
GeneOntologyBiologicalProcess	aspartate metabolic process	ADSS2 ADSS1	3.80e-04	9	68	2	GO:0006531
GeneOntologyBiologicalProcess	aspartate family amino acid metabolic process	ASNSD1 ADSS2 ADSS1	5.33e-04	48	68	3	GO:0009066
GeneOntologyBiologicalProcess	iris morphogenesis	HIPK1 WNT2B	5.78e-04	11	68	2	GO:0061072
GeneOntologyBiologicalProcess	UMP biosynthetic process	UCK2 UCK1	5.78e-04	11	68	2	GO:0006222
GeneOntologyBiologicalProcess	CMP metabolic process	UCK2 UCK1	5.78e-04	11	68	2	GO:0046035
GeneOntologyCellularComponent	extracellular matrix	ADAMTS12 CCN4 ADAMTSL1 FCGBP ZAN ADAMTS2 LRRC3B ADAMTS1 WNT2B ADAMTS20 EMILIN3 MUC5B USH2A	1.95e-07	656	69	13	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	ADAMTS12 CCN4 ADAMTSL1 FCGBP ZAN ADAMTS2 LRRC3B ADAMTS1 WNT2B ADAMTS20 EMILIN3 MUC5B USH2A	2.02e-07	658	69	13	GO:0030312
GeneOntologyCellularComponent	intercellular canaliculus	ABCB11 ABCB4	3.81e-04	9	69	2	GO:0046581
MousePheno	middle ear effusion	FBXO11 SALL4 MUC5B	4.01e-06	9	52	3	MP:0030410
MousePheno	abnormal tympanic cavity morphology	FBXO11 SALL4 MUC5B	2.63e-05	16	52	3	MP:0030154
Domain	Peptidase_M12B_ADAM-TS	ADAMTS12 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20	2.22e-08	24	68	5	IPR013273
Domain	TSP_1	ADAMTS12 CCN4 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20	1.07e-07	63	68	6	PF00090
Domain	TSP1	ADAMTS12 CCN4 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20	1.30e-07	65	68	6	SM00209
Domain	TSP1_rpt	ADAMTS12 CCN4 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20	1.30e-07	65	68	6	IPR000884
Domain	TSP1	ADAMTS12 CCN4 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20	1.30e-07	65	68	6	PS50092
Domain	Peptidase_M12B_N	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	2.88e-07	39	68	5	IPR002870
Domain	Pep_M12B_propep	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	2.88e-07	39	68	5	PF01562
Domain	DISINTEGRIN_1	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	3.28e-07	40	68	5	PS00427
Domain	Reprolysin	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	3.28e-07	40	68	5	PF01421
Domain	ADAM_MEPRO	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	3.28e-07	40	68	5	PS50215
Domain	DISINTEGRIN_2	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	3.28e-07	40	68	5	PS50214
Domain	Peptidase_M12B	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	3.28e-07	40	68	5	IPR001590
Domain	Disintegrin_dom	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	3.73e-07	41	68	5	IPR001762
Domain	PLAC	ADAMTS12 PCSK5 ADAMTSL1 ADAMTS2	5.98e-07	19	68	4	PS50900
Domain	PLAC	ADAMTS12 PCSK5 ADAMTSL1 ADAMTS2	5.98e-07	19	68	4	IPR010909
Domain	ADAM_spacer1	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20	1.35e-06	23	68	4	IPR010294
Domain	ADAM_spacer1	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20	1.35e-06	23	68	4	PF05986
Domain	TIL	FCGBP ZAN MUC5B	9.92e-06	12	68	3	PF01826
Domain	C8	FCGBP ZAN MUC5B	9.92e-06	12	68	3	PF08742
Domain	VWC	CCN4 FCGBP ZAN MUC5B	1.08e-05	38	68	4	SM00214
Domain	MetalloPept_cat_dom	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	1.14e-05	81	68	5	IPR024079
Domain	-	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	1.14e-05	81	68	5	3.40.390.10
Domain	Unchr_dom_Cys-rich	FCGBP ZAN MUC5B	1.29e-05	13	68	3	IPR014853
Domain	C8	FCGBP ZAN MUC5B	1.29e-05	13	68	3	SM00832
Domain	Adenylsucc_synt	ADSS2 ADSS1	1.31e-05	2	68	2	SM00788
Domain	Adenylsucc_synt	ADSS2 ADSS1	1.31e-05	2	68	2	PF00709
Domain	Adenylosuccin_syn_Lys_AS	ADSS2 ADSS1	1.31e-05	2	68	2	IPR033128
Domain	ADENYLOSUCCIN_SYN_2	ADSS2 ADSS1	1.31e-05	2	68	2	PS00513
Domain	Adenylosuccin_syn_GTP-bd	ADSS2 ADSS1	1.31e-05	2	68	2	IPR018220
Domain	Adenylosuccinate_synthetase	ADSS2 ADSS1	1.31e-05	2	68	2	IPR001114
Domain	ADENYLOSUCCIN_SYN_1	ADSS2 ADSS1	1.31e-05	2	68	2	PS01266
Domain	VWF_dom	CCN4 FCGBP ZAN MUC5B	1.62e-05	42	68	4	IPR001007
Domain	TIL_dom	FCGBP ZAN MUC5B	1.63e-05	14	68	3	IPR002919
Domain	VWD	FCGBP ZAN MUC5B	2.50e-05	16	68	3	SM00216
Domain	VWF_type-D	FCGBP ZAN MUC5B	2.50e-05	16	68	3	IPR001846
Domain	VWFD	FCGBP ZAN MUC5B	2.50e-05	16	68	3	PS51233
Domain	VWD	FCGBP ZAN MUC5B	2.50e-05	16	68	3	PF00094
Domain	ZINC_PROTEASE	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	2.88e-05	98	68	5	PS00142
Domain	TILa	FCGBP ZAN	3.91e-05	3	68	2	PF12714
Domain	TILa_dom	FCGBP ZAN	3.91e-05	3	68	2	IPR025615
Domain	PRK/URK	UCK2 UCK1	3.91e-05	3	68	2	IPR006083
Domain	PRK	UCK2 UCK1	3.91e-05	3	68	2	PF00485
Domain	VWC_out	FCGBP ZAN MUC5B	4.29e-05	19	68	3	SM00215
Domain	Uridine_kinase-like	UCK2 UCK1	7.80e-05	4	68	2	IPR000764
Domain	EGF	PCSK5 FCGBP EGF ZAN ADGRE5 ADAM22	2.12e-04	235	68	6	SM00181
Domain	ZF_UBR	UBR3 FBXO11	2.71e-04	7	68	2	PS51157
Domain	zf-UBR	UBR3 FBXO11	2.71e-04	7	68	2	PF02207
Domain	Znf_UBR	UBR3 FBXO11	2.71e-04	7	68	2	IPR003126
Domain	ZnF_UBR1	UBR3 FBXO11	2.71e-04	7	68	2	SM00396
Domain	EGF-like_dom	PCSK5 FCGBP EGF ZAN ADGRE5 ADAM22	2.90e-04	249	68	6	IPR000742
Domain	VWFC_1	CCN4 ZAN MUC5B	3.02e-04	36	68	3	PS01208
Domain	VWFC_2	CCN4 ZAN MUC5B	3.55e-04	38	68	3	PS50184
Domain	ABC_transporter_CS	ABCA4 ABCB11 ABCB4	4.79e-04	42	68	3	IPR017871
Domain	ABC_tran	ABCA4 ABCB11 ABCB4	7.10e-04	48	68	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA4 ABCB11 ABCB4	7.10e-04	48	68	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCA4 ABCB11 ABCB4	7.54e-04	49	68	3	PS00211
Domain	ABC_transporter-like	ABCA4 ABCB11 ABCB4	8.00e-04	50	68	3	IPR003439
Domain	OA_transporter	SLCO1C1 SLCO2A1	8.42e-04	12	68	2	IPR004156
Domain	OATP	SLCO1C1 SLCO2A1	8.42e-04	12	68	2	PF03137
Domain	PLAC	PCSK5 ADAMTSL1	1.16e-03	14	68	2	PF08686
Domain	Glyco_hormone_CN	CCN4 MUC5B	1.33e-03	15	68	2	IPR006208
Domain	Cys_knot	CCN4 MUC5B	1.33e-03	15	68	2	PF00007
Domain	AAA+_ATPase	ABCA4 IGHMBP2 ABCB11 ABCB4	1.88e-03	144	68	4	IPR003593
Domain	AAA	ABCA4 IGHMBP2 ABCB11 ABCB4	1.88e-03	144	68	4	SM00382
Domain	CTCK_1	CCN4 MUC5B	1.92e-03	18	68	2	PS01185
Domain	EGF_1	EGF ZAN NTN5 USH2A ADAM22	2.36e-03	255	68	5	PS00022
Domain	Growth_fac_rcpt_	PCSK5 CCN4 EGF ADGRE5	2.52e-03	156	68	4	IPR009030
Domain	CT	CCN4 MUC5B	2.88e-03	22	68	2	SM00041
Domain	ABC_membrane	ABCB11 ABCB4	3.42e-03	24	68	2	PF00664
Domain	P-loop_NTPase	ABCA4 ADSS2 IGHMBP2 GET3 ABCB11 UCK2 UCK1 ABCB4 ADSS1	3.50e-03	848	68	9	IPR027417
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS12 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20 MUC5B	1.19e-07	68	49	6	M27303
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS12 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20	2.17e-07	39	49	5	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS12 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20	2.17e-07	39	49	5	MM15165
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS12 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20 MUC5B	1.99e-06	109	49	6	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS12 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20 MUC5B	2.21e-06	111	49	6	M27416
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTS12 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20 MUC5B	9.58e-06	143	49	6	M27275
Pathway	BIOCARTA_MRP_PATHWAY	ABCB11 ABCB4	1.76e-04	6	49	2	M22078
Pathway	REACTOME_DISEASES_OF_METABOLISM	ADAMTS12 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20 MUC5B	2.16e-04	250	49	6	M27554
Pathway	REACTOME_METABOLISM_OF_NUCLEOTIDES	ADSS2 UCK2 UCK1 ADSS1	3.52e-04	97	49	4	MM14607
Pathway	REACTOME_METABOLISM_OF_NUCLEOTIDES	ADSS2 UCK2 UCK1 ADSS1	3.52e-04	97	49	4	M777
Pathway	KEGG_ABC_TRANSPORTERS	ABCA4 ABCB11 ABCB4	4.73e-04	44	49	3	M11911
Pathway	REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS	ADSS2 ADSS1	6.38e-04	11	49	2	M2071
Pathway	REACTOME_PYRIMIDINE_SALVAGE	UCK2 UCK1	6.38e-04	11	49	2	M27689
Pathway	REACTOME_PYRIMIDINE_SALVAGE	UCK2 UCK1	6.38e-04	11	49	2	MM15422
Pathway	REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS	ADSS2 ADSS1	6.38e-04	11	49	2	MM15425
Pathway	REACTOME_TRANSPORT_OF_ORGANIC_ANIONS	SLCO1C1 SLCO2A1	6.38e-04	11	49	2	M930
Pathway	REACTOME_TRANSPORT_OF_ORGANIC_ANIONS	SLCO1C1 SLCO2A1	7.64e-04	12	49	2	MM15476
Pathway	REACTOME_NUCLEOTIDE_BIOSYNTHESIS	ADSS2 ADSS1	1.05e-03	14	49	2	M27830
Pathway	REACTOME_NUCLEOTIDE_BIOSYNTHESIS	ADSS2 ADSS1	1.05e-03	14	49	2	MM15551
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20	6.94e-09	12	69	4	25770910
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS12 CCN4 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20	8.83e-09	75	69	6	20637190
Pubmed	Hydrophilic bile acids prevent liver damage caused by lack of biliary phospholipid in Mdr2-/- mice.	ABCB11 ABCB4	3.88e-06	2	69	2	30416103
Pubmed	Expression Analysis of ATP-Binding Cassette Transporters ABCB11 and ABCB4 in Primary Sclerosing Cholangitis and Variety of Pediatric and Adult Cholestatic and Noncholestatic Liver Diseases.	ABCB11 ABCB4	3.88e-06	2	69	2	31886153
Pubmed	Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy.	ABCB11 ABCB4	3.88e-06	2	69	2	15077010
Pubmed	Molecular cloning and expression of a mouse muscle cDNA encoding adenylosuccinate synthetase.	ADSS2 ADSS1	3.88e-06	2	69	2	1939273
Pubmed	Tetrahydroxylated bile acids improve cholestatic liver and bile duct injury in the Mdr2-/- mouse model of sclerosing cholangitis via immunomodulatory effects.	ABCB11 ABCB4	3.88e-06	2	69	2	35691019
Pubmed	ABCB4 and ABCB11 mutations in intrahepatic cholestasis of pregnancy in an Italian population.	ABCB11 ABCB4	3.88e-06	2	69	2	23022423
Pubmed	BSEP and MDR3: Useful Immunohistochemical Markers to Discriminate Hepatocellular Carcinomas From Intrahepatic Cholangiocarcinomas and Hepatoid Carcinomas.	ABCB11 ABCB4	3.88e-06	2	69	2	26735860
Pubmed	Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy.	ABCB11 ABCB4	3.88e-06	2	69	2	16890614
Pubmed	Purification, activity, and expression levels of two uridine-cytidine kinase isoforms in neuroblastoma cell lines.	UCK2 UCK1	3.88e-06	2	69	2	27906629
Pubmed	Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6.	UBR3 FBXO11	3.88e-06	2	69	2	26059563
Pubmed	Variations in the response of mouse isozymes of adenylosuccinate synthetase to inhibitors of physiological relevance.	ADSS2 ADSS1	3.88e-06	2	69	2	12482871
Pubmed	Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury.	ABCB11 ABCB4	3.88e-06	2	69	2	17264802
Pubmed	The pivotal role of uridine-cytidine kinases in pyrimidine metabolism and activation of cytotoxic nucleoside analogues in neuroblastoma.	UCK2 UCK1	3.88e-06	2	69	2	27239701
Pubmed	Hepatic immunohistochemistry of bile transporters in progressive familial intrahepatic cholestasis.	ABCB11 ABCB4	3.88e-06	2	69	2	26845599
Pubmed	The role of ABC transporters' gene polymorphism in the etiology of intrahepatic cholestasis of pregnancy.	ABCB11 ABCB4	3.88e-06	2	69	2	30091450
Pubmed	Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases.	UCK2 UCK1	3.88e-06	2	69	2	11306702
Pubmed	Biliary transporter gene mutations in severe intrahepatic cholestasis of pregnancy: Diagnostic and management implications.	ABCB11 ABCB4	3.88e-06	2	69	2	29992621
Pubmed	Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells.	ADSS2 ADSS1	3.88e-06	2	69	2	15786719
Pubmed	Common variants of ABCB4 and ABCB11 and plasma lipid levels: a study in sib pairs with gallstones, and controls.	ABCB11 ABCB4	3.88e-06	2	69	2	19408031
Pubmed	Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase.	ADSS2 ADSS1	3.88e-06	2	69	2	1592113
Pubmed	Amplification of an adenylosuccinate synthetase gene in alanosine-resistant murine T-lymphoma cells. Molecular cloning of a cDNA encoding the "non-muscle" isozyme.	ADSS2 ADSS1	3.88e-06	2	69	2	8308018
Pubmed	BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis.	ABCB11 ABCB4	3.88e-06	2	69	2	14999697
Pubmed	Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11).	ABCB11 ABCB4	3.88e-06	2	69	2	16763017
Pubmed	A comprehensive analysis of common genetic variation around six candidate loci for intrahepatic cholestasis of pregnancy.	ABCB11 ABCB4	3.88e-06	2	69	2	24366234
Pubmed	Heterozygous mutations of ATP8B1, ABCB11 and ABCB4 cause mild forms of Progressive Familial Intrahepatic Cholestasis in a pediatric cohort.	ABCB11 ABCB4	1.16e-05	3	69	2	34942279
Pubmed	Searching the second hit in patients with inherited retinal dystrophies and monoallelic variants in ABCA4, USH2A and CEP290 by whole-gene targeted sequencing.	ABCA4 USH2A	1.16e-05	3	69	2	30190494
Pubmed	Clinical phenotype of adult-onset liver disease in patients with variants in ABCB4, ABCB11, and ATP8B1.	ABCB11 ABCB4	1.16e-05	3	69	2	35894240
Pubmed	Role of common canalicular transporter gene variations in aetiology of idiopathic gallstones in childhood.	ABCB11 ABCB4	1.16e-05	3	69	2	20163776
Pubmed	Sequencing of FIC1, BSEP and MDR3 in a large cohort of patients with cholestasis revealed a high number of different genetic variants.	ABCB11 ABCB4	1.16e-05	3	69	2	28733223
Pubmed	Hepatobiliary transporter expression and post-operative jaundice in patients undergoing partial hepatectomy.	ABCB11 ABCB4	1.16e-05	3	69	2	22098322
Pubmed	A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke.	ADAMTS12 ADAMTS2	1.16e-05	3	69	2	22990015
Pubmed	DHPLC screening for mutations in progressive familial intrahepatic cholestasis patients.	ABCB11 ABCB4	1.16e-05	3	69	2	20414253
Pubmed	ATP8B1, ABCB11, and ABCB4 Genes Defects: Novel Mutations Associated with Cholestasis with Different Phenotypes and Outcomes.	ABCB11 ABCB4	1.16e-05	3	69	2	33915153
Pubmed	The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family.	ADAMTS2 ADAMTS1	1.16e-05	3	69	2	26025392
Pubmed	Cryptogenic cholestasis in young and adults: ATP8B1, ABCB11, ABCB4, and TJP2 gene variants analysis by high-throughput sequencing.	ABCB11 ABCB4	2.32e-05	4	69	2	29238877
Pubmed	Analysis of gene mutations in children with cholestasis of undefined etiology.	ABCB11 ABCB4	2.32e-05	4	69	2	20683201
Pubmed	Panel-based NGS Reveals Novel Pathogenic Mutations in Autosomal Recessive Retinitis Pigmentosa.	ABCA4 USH2A	2.32e-05	4	69	2	26806561
Pubmed	ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats.	ADAMTS2 ADAMTS1	2.32e-05	4	69	2	10094461
Pubmed	Familial intrahepatic cholestasis: New and wide perspectives.	ABCB11 ABCB4	2.32e-05	4	69	2	31105019
Pubmed	ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.	ADAMTS12 ADAMTS1	2.32e-05	4	69	2	29135310
Pubmed	[ADAMTS family--new extracellular matrix degrading enzyme].	ADAMTS2 ADAMTS1	3.86e-05	5	69	2	11831030
Pubmed	Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells.	ABCB11 ABCB4	3.86e-05	5	69	2	15159385
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	ZNF672 EGF ZAN SLCO1C1 LRRC3B TLR2 TRPS1 LHX6	5.64e-05	674	69	8	37196079
Pubmed	Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage.	ADSS2 ADSS1	5.79e-05	6	69	2	29079593
Pubmed	Exome sequencing of index patients with retinal dystrophies as a tool for molecular diagnosis.	ABCA4 USH2A	5.79e-05	6	69	2	23940504
Pubmed	Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism.	ABCB11 ABCB4	1.08e-04	8	69	2	11279518
Pubmed	Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.	ABCB11 MUC5B ABCB4	1.14e-04	47	69	3	11208732
Pubmed	A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.	ADAMTS2 ITPR1	1.38e-04	9	69	2	31491533
Pubmed	Role of the C-terminal binding protein PXDLS motif binding cleft in protein interactions and transcriptional repression.	HIPK1 TRPS1	1.38e-04	9	69	2	16940173
Pubmed	Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes.	ABCB11 ABCB4	1.73e-04	10	69	2	12068294
Pubmed	DYRK3 phosphorylates SNAPIN to regulate axonal retrograde transport and neurotransmitter release.	DNAJA2 ADAM22	1.73e-04	10	69	2	36585413
Pubmed	Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.	ADSS2 ABCB4	1.73e-04	10	69	2	25134534
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS12 ADAMTS2	1.73e-04	10	69	2	11167130
Pubmed	Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.	FBXO11 USH2A	2.11e-04	11	69	2	24349473
Pubmed	Deubiquitinase USP28 inhibits ubiquitin ligase KLHL2-mediated uridine-cytidine kinase 1 degradation and confers sensitivity to 5'-azacytidine-resistant human leukemia cells.	UCK2 UCK1	2.11e-04	11	69	2	31938050
Pubmed	Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties.	SLCO1C1 SLCO2A1	2.11e-04	11	69	2	14579113
Pubmed	De novo purine nucleotide biosynthesis.	ADSS2 ADSS1	2.11e-04	11	69	2	1574589
Pubmed	Lifelong persistence of nuclear RNAs in the mouse brain.	UCK2 UCK1	2.98e-04	13	69	2	38574132
Pubmed	Pediatric Genetic Cholestatic Liver Disease Overview	ABCB11 ABCB4	3.48e-04	14	69	2	36108118
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DNAJC10 ADAMTS1 DNAJA2 IL21R TRPS1 EMILIN3 UCK2 CUL7 ARAP2	3.52e-04	1116	69	9	31753913
Pubmed	MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.	HLA-C IL21R	4.01e-04	15	69	2	21964024
Pubmed	ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.	ADAMTS2 ADAMTS1	4.01e-04	15	69	2	38871984
Pubmed	ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family.	ADAMTS2 ADAMTS1	5.18e-04	17	69	2	10464288
Pubmed	A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex.	WNT2B LHX6	5.18e-04	17	69	2	17694053
Pubmed	Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.	ADAMTS1 ADAMTS20	5.18e-04	17	69	2	22183742
Pubmed	Development of a diagnostic genetic test for simplex and autosomal recessive retinitis pigmentosa.	ABCA4 USH2A	5.81e-04	18	69	2	20591486
Pubmed	Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.	TRPS1 SALL4 ITPR1	5.92e-04	82	69	3	31073041
Pubmed	Early thalamocortical tract guidance and topographic sorting of thalamic projections requires LIM-homeodomain gene Lhx2.	WNT2B LHX6	6.49e-04	19	69	2	17493606
Pubmed	Hundreds of variants clustered in genomic loci and biological pathways affect human height.	PCSK5 BNC2 SLCO1C1 NCKAP5	6.60e-04	198	69	4	20881960
Pubmed	ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.	ADAMTS1 ADAMTS20	7.20e-04	20	69	2	19922873
Pubmed	Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.	PCSK5 ARAP2	7.95e-04	21	69	2	22959728
Pubmed	A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.	SALL4 SF1	8.73e-04	22	69	2	19483677
Pubmed	Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.	EGF MUC5B	8.73e-04	22	69	2	12768436
Pubmed	Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.	GET3 UBR3	8.73e-04	22	69	2	24981174
Pubmed	Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development.	WNT2B SALL4	9.55e-04	23	69	2	20159597
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ADAMTS1 HIPK1 DNAJA2 TRPS1 FBXO11 NCKAP5 ZNF227 SF1 ADAM22	9.64e-04	1285	69	9	35914814
Pubmed	Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly.	ADAMTS2 ADAMTS1	1.04e-03	24	69	2	29791855
Pubmed	Adult-onset Alopecia areata is a complex polygenic trait in the C3H/HeJ mouse model.	TRPS1 ADAMTS20	1.04e-03	24	69	2	15245428
Pubmed	c-IAP1 binds and processes PCSK9 protein: linking the c-IAP1 in a TNF-α pathway to PCSK9-mediated LDLR degradation pathway.	DNAJC10 DNAJA2	1.04e-03	24	69	2	23085658
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	BNC2 SALL4 USH2A	1.08e-03	101	69	3	18519826
Pubmed	Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction.	DNAJC10 DNAJA2	1.13e-03	25	69	2	27483141
Pubmed	Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.	CHRNA5 ITPR1	1.63e-03	30	69	2	22837378
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	PCSK5 PPIG GET3	1.69e-03	118	69	3	21078624
Pubmed	The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor.	TCEA2 SF1	1.97e-03	33	69	2	9765201
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS12 ADAMTS2 ADAMTS1 ADAMTS20	2.28e-07	19	52	4	50
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR3 FBXO11	1.69e-04	7	52	2	785
GeneFamily	ATP binding cassette subfamily B	ABCB11 ABCB4	4.39e-04	11	52	2	806
Coexpression	NABA_MATRISOME	ADAMTS12 PCSK5 CCN4 ADAMTSL1 EGF ADAMTS2 ADAMTS1 WNT2B NTN5 ADAMTS20 EMILIN3 MUC5B USH2A ADAM22	3.76e-07	1026	69	14	M5889
Coexpression	NABA_MATRISOME	ADAMTS12 PCSK5 CCN4 ADAMTSL1 EGF ADAMTS2 ADAMTS1 WNT2B NTN5 ADAMTS20 EMILIN3 MUC5B ADAM22	1.95e-06	1008	69	13	MM17056
Coexpression	NABA_ECM_REGULATORS	ADAMTS12 PCSK5 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	3.11e-06	238	69	7	M3468
Coexpression	NABA_ECM_REGULATORS	ADAMTS12 PCSK5 ADAMTSL1 ADAMTS2 ADAMTS1 ADAMTS20 ADAM22	3.48e-06	242	69	7	MM17062
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS12 PCSK5 ADAMTSL1 EGF ADAMTS2 ADAMTS1 WNT2B ADAMTS20 MUC5B ADAM22	2.24e-05	738	69	10	MM17058
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS12 PCSK5 ADAMTSL1 EGF ADAMTS2 ADAMTS1 WNT2B ADAMTS20 MUC5B ADAM22	2.60e-05	751	69	10	M5885
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_1000	CCN4 BNC2 ADAMTSL1 SNCAIP ADAMTS2 LRRC3B SLCO2A1 TRPS1 EMILIN3 SALL4 ZNF784 LHX6 ADAM22	5.06e-06	967	64	13	Facebase_RNAseq_e8.5_Paraxial Mesoderm_1000
CoexpressionAtlas	facebase_RNAseq_e14.5_palate_poster_distal_ERK2_WT_2500_K1	ADAMTS12 PCSK5 CCN4 PPIG ADAMTSL1 SNCAIP ADAMTS2 TLR2 TRPS1 EMILIN3 ZNF784 LHX6 ADAM22 CREB3L2	7.59e-06	1166	64	14	facebase_RNAseq_e14.5_palate_poster_distal_ERK2_WT_2500_K1
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000_k-means-cluster#5	BNC2 ADAMTSL1 ADAMTS2 SLCO2A1 TRPS1 EMILIN3 LHX6	8.63e-06	244	64	7	Facebase_RNAseq_e9.5_Olfactory Placode_1000_K5
CoexpressionAtlas	FacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#1	ADAMTS12 TCEA2 BNC2 ADAMTSL1 SNCAIP HLA-C ADAMTS2 SLCO2A1 TRPS1 EMILIN3 ADGRE5 LHX6	1.05e-05	878	64	12	Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_2500_K1
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#5	TCEA2 BNC2 ZNF672 SNCAIP HLA-C SLCO2A1 TRPS1 EMILIN3 UBR3 ADGRE5 LHX6	1.09e-05	734	64	11	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_2500_K5
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_500_k-means-cluster#5	BNC2 ADAMTSL1 ADAMTS2 EMILIN3 LHX6 ITPR1	1.32e-05	172	64	6	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_500_K5
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000_k-means-cluster#1	BNC2 SNCAIP SLCO2A1 TRPS1 EMILIN3 LHX6 ITPR1	1.48e-05	265	64	7	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_1000_K1
CoexpressionAtlas	FacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_1000_k-means-cluster#3	CCN4 BNC2 ADAMTSL1 ADAMTS2 SLCO2A1 TRPS1 EMILIN3 LHX6	1.95e-05	384	64	8	Facebase_RNAseq_e9.5_Facial Mesenchyne_1000_K3
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_k-means-cluster#5_top-relative-expression-ranked_1000	PCSK5 CCN4 BNC2 ADAMTSL1 ADAMTS2 ADAMTS20 ADAM22	2.52e-05	288	64	7	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_1000_k5
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_1000	CCN4 BNC2 ADAMTSL1 ADAMTS2 LRRC3B SLCO2A1 TRPS1 EMILIN3 NCKAP5 ZNF784 LHX6 ADAM22	2.73e-05	967	64	12	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_1000
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000	CCN4 BNC2 ADAMTSL1 SNCAIP ADAMTS2 SLCO2A1 TRPS1 EMILIN3 ZNF784 LHX6 ADAM22 ITPR1	2.87e-05	972	64	12	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_1000
CoexpressionAtlas	facebase_RNAseq_e14.5_palate_poster_oral_Tgfbr2_WT_2500_K4	ADAMTS12 PCSK5 TCEA2 CCN4 ADAMTSL1 SNCAIP TLR2 EMILIN3 CUL7 ZNF784 LHX6 ADAM22 CREB3L2	3.14e-05	1148	64	13	facebase_RNAseq_e14.5_palate_poster_oral_Tgfbr2_WT_2500_K4
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#5	TCEA2 BNC2 SNCAIP HLA-C SLCO2A1 TRPS1 EMILIN3 UBR3 ADGRE5 LHX6	5.86e-05	726	64	10	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_2500_k-means-cluster#4	TCEA2 BNC2 ZNF672 SNCAIP HLA-C TRPS1 EMILIN3 UBR3 ADGRE5 LHX6	6.20e-05	731	64	10	Facebase_RNAseq_e8.5_Paraxial Mesoderm_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#2	TCEA2 BNC2 SNCAIP HLA-C TRPS1 EMILIN3 UBR3 ADGRE5 LHX6	7.08e-05	596	64	9	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K2
CoexpressionAtlas	FacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#4	TCEA2 BNC2 PPIG SNCAIP HLA-C SLCO2A1 TRPS1 EMILIN3 ADGRE5 LHX6	7.18e-05	744	64	10	Facebase_RNAseq_e10.5_Medial Nasal Eminence_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_500_k-means-cluster#3	BNC2 ADAMTSL1 ADAMTS2 SLCO2A1 EMILIN3 LHX6	1.04e-04	249	64	6	Facebase_RNAseq_e8.5_Paraxial Mesoderm_500_K3
CoexpressionAtlas	FacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_500_k-means-cluster#3	BNC2 ADAMTSL1 ADAMTS2 EMILIN3 LHX6	1.22e-04	160	64	5	Facebase_RNAseq_e9.5_Facial Mesenchyne_500_K3
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_1000_k-means-cluster#1	BNC2 ADAMTSL1 ADAMTS2 SLCO2A1 TRPS1 EMILIN3 LHX6	1.24e-04	371	64	7	Facebase_RNAseq_e9.5_Maxillary Arch_1000_K1
CoexpressionAtlas	kidney_P0_JuxtaGlom_Ren1_k-means-cluster#2_top-relative-expression-ranked_1000	ADAMTS1 SLCO2A1 ADAM22 ARAP2 ITPR1	1.33e-04	163	64	5	gudmap_kidney_P0_JuxtaGlom_Ren1_k2_1000
CoexpressionAtlas	kidney_adult_GlomCapSys_Tie2_k-means-cluster#4_top-relative-expression-ranked_200	HLA-C SLCO2A1 ARAP2	1.34e-04	33	64	3	gudmap_kidney_adult_GlomCapSys_Tie2_k4_200
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_1000	CCN4 BNC2 ADAMTSL1 ADAMTS2 SLCO2A1 TRPS1 EMILIN3 SALL4 ZNF784 LHX6 ADAM22	1.34e-04	967	64	11	Facebase_RNAseq_e9.5_Maxillary Arch_1000
CoexpressionAtlas	FacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_1000	CCN4 BNC2 ADAMTSL1 ADAMTS2 SLCO2A1 TRPS1 EMILIN3 SALL4 ZNF784 LHX6 ADAM22	1.35e-04	968	64	11	Facebase_RNAseq_e9.5_Facial Mesenchyne_1000
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#2	TCEA2 BNC2 SNCAIP HLA-C TRPS1 EMILIN3 ADGRE5 LHX6 ITPR1	1.40e-04	652	64	9	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_2500_K2
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_1000_k-means-cluster#5	BNC2 ADAMTSL1 ADAMTS2 SLCO2A1 EMILIN3 LHX6	1.82e-04	276	64	6	Facebase_RNAseq_e10.5_Olfactory Pit_1000_K5
CoexpressionAtlas	FacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_1000_k-means-cluster#4	BNC2 ADAMTSL1 ADAMTS2 SLCO2A1 EMILIN3 LHX6	2.75e-04	298	64	6	Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_1000_K4
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#1	TCEA2 BNC2 SNCAIP HLA-C TRPS1 EMILIN3 ADGRE5 LHX6	3.77e-04	589	64	8	Facebase_RNAseq_e9.5_Maxillary Arch_2500_K1
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#4	TCEA2 SNCAIP HLA-C SLCO2A1 TRPS1 EMILIN3 ADGRE5 LHX6	3.86e-04	591	64	8	Facebase_RNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_2500_k-means-cluster#2	TCEA2 BNC2 SNCAIP HLA-C TRPS1 EMILIN3 ADGRE5 LHX6	4.60e-04	607	64	8	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_2500_K2
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_1000_k-means-cluster#2	BNC2 SNCAIP SLCO2A1 TRPS1 EMILIN3 LHX6	4.73e-04	330	64	6	Facebase_RNAseq_e8.5_Paraxial Mesoderm_1000_K2
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_500	BNC2 ADAMTSL1 ADAMTS2 SLCO2A1 EMILIN3 NCKAP5 LHX6	5.83e-04	479	64	7	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_500
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000	BNC2 ADAMTSL1 ADAMTS2 SLCO2A1 TRPS1 EMILIN3 SALL4 NCKAP5 LHX6 ARAP2	6.22e-04	973	64	10	Facebase_RNAseq_e9.5_Olfactory Placode_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_1000	CCN4 BNC2 ADAMTSL1 ADAMTS2 SLCO2A1 TRPS1 EMILIN3 SALL4 ZNF784 LHX6	6.47e-04	978	64	10	Facebase_RNAseq_e10.5_Mandibular Arch_1000
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_500	BNC2 ADAMTSL1 ADAMTS2 SLCO2A1 EMILIN3 SALL4 LHX6	6.58e-04	489	64	7	Facebase_RNAseq_e8.5_Paraxial Mesoderm_500
CoexpressionAtlas	FacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_2500_k-means-cluster#2	TCEA2 BNC2 SNCAIP HLA-C TRPS1 EMILIN3 ADGRE5 LHX6	6.66e-04	642	64	8	Facebase_RNAseq_e9.5_Facial Mesenchyne_2500_K2
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_500	PPIG SNCAIP TRPS1 UBR3 SALL4 ADAM22 ARAP2	6.82e-04	492	64	7	Facebase_RNAseq_e10.5_Maxillary Arch_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#4	BNC2 ADAMTSL1 SNCAIP ADAMTS2 SLCO2A1 TRPS1 EMILIN3 LHX6	7.58e-04	655	64	8	Facebase_RNAseq_e10.5_Maxillary Arch_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_2500_k-means-cluster#2	TCEA2 BNC2 SNCAIP HLA-C TRPS1 EMILIN3 ADGRE5 LHX6	7.58e-04	655	64	8	Facebase_RNAseq_e9.5_Olfactory Placode_2500_K2
CoexpressionAtlas	mendel_RNAseq_e18.5_Urothelium_Krt5CreRFP_2500_K3	HLA-C ADAMTS1 SLCO2A1 ARAP2	7.60e-04	136	64	4	mendel_RNAseq_e18.5_Urothelium_Krt5CreRFP_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_500_k-means-cluster#3	BNC2 ADAMTSL1 ADAMTS2 LHX6	7.81e-04	137	64	4	Facebase_RNAseq_e9.5_Maxillary Arch_500_K3
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_top-relative-expression-ranked_1000	BNC2 ADAMTSL1 ADAMTS2 TRPS1 ADAMTS20 TMPRSS2 EMILIN3 NCKAP5 ARAP2	7.90e-04	826	64	9	DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_1000
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_1000_k-means-cluster#4	ADAMTSL1 ADAMTS2 SLCO2A1 EMILIN3 LHX6	7.99e-04	241	64	5	Facebase_RNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_1000_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#3	TCEA2 BNC2 SNCAIP HLA-C SLCO2A1 TRPS1 EMILIN3 ADGRE5 LHX6	8.45e-04	834	64	9	Facebase_RNAseq_e10.5_Mandibular Arch_2500_K3
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_500_k-means-cluster#2	BNC2 SLCO2A1 EMILIN3 LHX6	1.01e-03	147	64	4	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_500_K2
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 ZAN ADAMTS20 SALL4 MUC5B USH2A	4.17e-07	184	69	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 ZAN ADAMTS20 SALL4 MUC5B USH2A	4.17e-07	184	69	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 ZAN ADAMTS20 SALL4 MUC5B USH2A	4.17e-07	184	69	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 PCSK5 BNC2 SNCAIP ADAMTS1 ADAM22	4.31e-07	185	69	6	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	ADAMTS12 CCN4 SLCO1C1 ADAMTS2 ADAMTS1 ITPR1	4.45e-07	186	69	6	cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BNC2 ADAMTS2 TLR2 WNT2B TRPS1 ADGRE5	5.04e-07	190	69	6	2d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	PCSK5 BNC2 ADAMTS2 TRPS1 CREB3L2 ITPR1	5.35e-07	192	69	6	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	BNC2 ADAMTSL1 HLA-C ADAMTS1 SLCO2A1 WNT2B	5.69e-07	194	69	6	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature\|E16.5-samps / Age Group, Lineage, Cell class and subclass	TCEA2 ADAMTS2 ABCB11 ADAMTS20 EMILIN3	1.74e-06	129	69	5	5e4783cc63afdeaebdfaecb72f95f3efc8d3c4a3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 SLCO1C1 MICALL2 ADAMTS2 SALL4	5.47e-06	163	69	5	bbc078761c5043af13d9a6fcf3145a3e300bae5e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 SLCO1C1 MICALL2 ADAMTS2 SALL4	5.47e-06	163	69	5	8e32b6431e1862572663aa6ddc4ea299c6acc8a6
ToppCell	metastatic_Brain-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	TCEA2 BNC2 TLR2 TRPS1 ADGRE5	6.90e-06	171	69	5	0d14bc9688c427ba2265984987dc3eea195b19eb
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CCN4 ADAMTS2 ADAMTS1 CREB3L2	8.39e-06	178	69	5	d4ecb84e9b1f4ec49c519321156aa10f9bd34cce
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	ADAMTS12 CCN4 BNC2 ADAMTS2 ADAMTS1	1.06e-05	187	69	5	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CCN4 ADAMTS2 ADAM22 ITPR1	1.12e-05	189	69	5	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CCN4 ADAMTS2 ADAM22 ITPR1	1.15e-05	190	69	5	2e592323085ba9c019d678ac2a784462ab470ed9
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CCN4 ADAMTS2 ADAM22 ITPR1	1.15e-05	190	69	5	445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CCN4 BNC2 ADAMTS2 ADAMTS1 WNT2B	1.15e-05	190	69	5	4f775ee24b14733f06ae40b45f2dc1a0f0df0705
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CCN4 BNC2 ADAMTS2 ADAMTS1 WNT2B	1.24e-05	193	69	5	cd45118ced91b10baed3b1068d4673ec99824b86
ToppCell	LV-14._Fibroblast_III\|LV / Chamber and Cluster_Paper	PCSK5 BNC2 ADAMTS1 TRPS1 CREB3L2	1.27e-05	194	69	5	927c26aea0147f7a4b8fb3f192de4de263f1b978
ToppCell	COPD-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	BNC2 ADAMTSL1 ADAMTS1 UCK2 ARAP2	1.27e-05	194	69	5	8dcde77767b23e75360adb316cdccf56a00e3726
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADAMTSL1 ADAMTS2 SALL4 ADGRE5	1.27e-05	194	69	5	90efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADAMTSL1 ADAMTS2 SALL4 ADGRE5	1.27e-05	194	69	5	df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCGBP IL21R UCK2 NCKAP5 ABCB4	1.27e-05	194	69	5	e56c6e5c9b7d287ae94566b561e21cec2055f83d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CCN4 ADAMTSL1 ADAMTS2 ADGRE5	1.30e-05	195	69	5	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADAMTSL1 SLCO1C1 ADAMTS2 ADGRE5	1.30e-05	195	69	5	803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FCGBP IL21R UCK2 NCKAP5 ABCB4	1.30e-05	195	69	5	85fee07d71c0393ea42bcf1130566dff4a62f507
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	BNC2 FCGBP HLA-C ADAMTS1 WNT2B	1.30e-05	195	69	5	633c7668fe365f7b0f7851cdc442d5dd89c454e2
ToppCell	COVID-19-kidney-Fibroblast-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADAMTS12 CCN4 ADAMTSL1 SNCAIP ADAMTS2	1.30e-05	195	69	5	3d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADAMTSL1 SLCO1C1 ADAMTS2 ADGRE5	1.30e-05	195	69	5	4f70157d42a16ff0259bc24a62803c4df4285c44
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CCN4 ADAMTSL1 ADAMTS2 ADGRE5 CREB3L2	1.37e-05	197	69	5	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	(0)_NK_FCGR3Apos\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PCSK5 BNC2 HLA-C ADAMTS1 ADGRE5	1.40e-05	198	69	5	13f10f9233fc1523f0da2d9d59f3ced9c51a603a
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS12 BNC2 SLCO1C1 ADAMTS1 EMILIN3	1.44e-05	199	69	5	3835452e4848d7f7dd8651c17b746b271ef39688
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS12 SLCO1C1 ADAMTS1 EMILIN3 MUC5B	1.44e-05	199	69	5	45c3b853900d8c3d5965117d904e3714100138bc
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS12 BNC2 SLCO1C1 ADAMTS1 EMILIN3	1.44e-05	199	69	5	9c2db0bb94cba71a3cc1827844da090e213e0258
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS12 BNC2 MICALL2 WNT2B CREB3L2	1.47e-05	200	69	5	5ad3ea1cf1fcd4100966c5517bc7ed0a1af54317
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Desmoid_Tumor\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	ADAMTS12 LRRC3B ADAMTS20 SALL4	3.52e-05	119	69	4	d8fbea9ded96fcc3ebdfb4d28873c563427ce811
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Desmoid_Tumor-7\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	ADAMTS12 LRRC3B ADAMTS20 SALL4	3.52e-05	119	69	4	9e38f13bf98b9ee44b178300e6f80fd08a006296
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-RGCs_3\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	SNCAIP ADAMTS2 ZNF227 ARAP2	5.93e-05	136	69	4	5e209185b5f6e9347829fc9066f0b2c3711df057
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADAMTS1 LHX6 CREB3L2 ADSS1	1.09e-04	159	69	4	c64fff8d89f84d1f5a0cc432e31f56f741162505
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	BNC2 LRRC3B SLCO2A1 CHRNA5	1.28e-04	166	69	4	6a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADAMTSL1 SLCO1C1 ADAMTS2	1.34e-04	168	69	4	d19a115365c5415e51c039718d7669de788fcf33
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CCN4 SNCAIP ADAMTS2	1.37e-04	169	69	4	a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADAMTSL1 ADAMTS2 ADGRE5	1.40e-04	170	69	4	fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADAMTSL1 ADAMTS2 ADGRE5	1.40e-04	170	69	4	03044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRC3B ADAMTS1 NCKAP5 ABCB4	1.40e-04	170	69	4	36dbbdb13f69307afd2122ff051b2980850c1f00
ToppCell	Endothelial-A-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	ADAMTSL1 ADAMTS1 SLCO2A1 LHX6	1.47e-04	172	69	4	a3201773a25832e92dd113fad165f1ecd37f5e91
ToppCell	ILEUM-inflamed-(1)_T_(gd)\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ZAN FBXO11 SALL4 ADGRE5	1.50e-04	173	69	4	85c3e227c81c6ab70148639381389fba3ac5e088
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 ADAMTS2 XPO5 PRORP	1.57e-04	175	69	4	1d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 ADAMTS2 ADGRE5 CREB3L2	1.57e-04	175	69	4	910a075ccaf79de22338ecf321fa0a867f3d7d75
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP SLCO2A1 MUC5B PRORP	1.57e-04	175	69	4	31f0fb2e47e357dbf9c15436b7df85b3c370ded7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 ADAMTS2 ADGRE5 CREB3L2	1.57e-04	175	69	4	f0c2eb82e17e8aec2cfa5d83169178f409cc1abc
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 ADAMTS2 XPO5 PRORP	1.57e-04	175	69	4	427a7ee92fe16a90625946492062d37aa0f7235b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CCN4 SLCO1C1 ADAMTS2 CREB3L2	1.60e-04	176	69	4	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_DCN\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ADAMTS12 ADAMTSL1 ADAMTS2 USH2A	1.60e-04	176	69	4	08f94b78b27feeb113dbfadbfa7fe34d08b2809b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CCN4 SLCO1C1 ADAMTS2 CREB3L2	1.60e-04	176	69	4	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	ADAMTS12 CCN4 ADAMTSL1 ADAMTS2	1.68e-04	178	69	4	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BNC2 FCGBP ZNF354A ABCB4	1.71e-04	179	69	4	06d412fc096d88de168969466ce422f0ab5553b2
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 PCSK5 BNC2 ADAM22	1.71e-04	179	69	4	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	COVID-19-Heart-EC_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PCSK5 SNCAIP LRRC3B ADAMTS1	1.71e-04	179	69	4	2a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-nan\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP MARF1 TMPRSS2 ITPR1	1.75e-04	180	69	4	a0faed4cf23f6d5e6e8f6b0284cea8a5bd0680a0
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BNC2 SLCO2A1 WNT2B LHX6	1.75e-04	180	69	4	27e8bbee388e64dd79d70b160b76d45b1f398006
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK5 ADAMTS1 SLCO2A1 ITPR1	1.79e-04	181	69	4	0ba91575fe8851788cebc4cf5a6d76680bf586c5
ToppCell	Club-club-8\|World / Class top	FCGBP NTN5 MUC5B PRORP	1.82e-04	182	69	4	8111d917e588008d947021460ddf8f1e7ae1337a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CCN4 ADAMTSL1 ADAMTS2	1.82e-04	182	69	4	44764676ed3f51ba171ce63f669390392fa50a43
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CCN4 ADAMTSL1 ADAMTS2	1.82e-04	182	69	4	d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 PCSK5 BNC2 ADAM22	1.86e-04	183	69	4	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP EGF DNAJC10 ITPR1	1.86e-04	183	69	4	ee9c88be88221b7ad4ea9f890b17d6156fb3432e
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-Goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP EGF DNAJC10 ITPR1	1.86e-04	183	69	4	c52b84034503d931f7b87312d2ff86daff14152d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CCN4 ADAMTSL1 ADAMTS2	1.90e-04	184	69	4	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PCSK5 CCN4 ADAMTS2 CREB3L2	1.94e-04	185	69	4	427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell	Control-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	ADAMTSL1 NTN5 UCK2 NCKAP5	1.94e-04	185	69	4	6814b3c94c7558443c038a227b5c8563d2cfeac4
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 PCSK5 BNC2 ADAM22	1.94e-04	185	69	4	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	Club\|World / Class top	FCGBP ADGRE5 MUC5B PRORP	1.94e-04	185	69	4	c3caf789e622ed515d143dc594158d52fdcffaef
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRC3B ADAMTS1 ADGRE5 NCKAP5	1.94e-04	185	69	4	0b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 BNC2 ADAMTS1 ADAM22	1.94e-04	185	69	4	e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CCN4 ABCA4 ADAMTS1 ABCB4	1.94e-04	185	69	4	e1fbec55b71f604189eb2431768fadbaa0453a83
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CCN4 ABCA4 ADAMTS1 ABCB4	1.94e-04	185	69	4	9d933cd5ebc8368fd37aa83113d2dfa6938ff72d
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 BNC2 ADAMTS1 ADAM22	1.98e-04	186	69	4	6add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS1 SLCO2A1 NCKAP5 LHX6	1.98e-04	186	69	4	41f1674afc17661eccaa779cdeb663db5e45685d
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ADAMTS2 TLR2 ADAMTS20 USH2A	1.98e-04	186	69	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-2\|TCGA-Kidney / Sample_Type by Project: Shred V9	ADAMTS12 SLCO1C1 ADAMTS2 LHX6	1.98e-04	186	69	4	1e6526fc9e9381b7ace864588cc7bd80194338d6
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FCGBP SLCO2A1 TLR2 TMPRSS2	1.98e-04	186	69	4	bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCell	droplet-Lung-LUNG-30m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS1 SLCO2A1 NCKAP5 LHX6	1.98e-04	186	69	4	aa006650cf21a2c51dfe1091681f67fdad939107
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SNCAIP SLCO1C1 SLCO2A1	2.02e-04	187	69	4	ddfc2d1d9fcc3d8e4d3d015576bb17eebf44ada9
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	ADAMTSL1 HLA-C SLCO2A1 WNT2B	2.02e-04	187	69	4	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADAMTS12 CCN4 ADAMTSL1 ADAMTS2	2.02e-04	187	69	4	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	PCSK5 SNCAIP LRRC3B ADAMTS1	2.02e-04	187	69	4	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	ADAMTS12 CCN4 BNC2 ADAMTS2	2.02e-04	187	69	4	a96495803ba13fcfadd1d83b3cf5774f3fed0a20
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 BNC2 ADAMTS1 ADAM22	2.06e-04	188	69	4	3177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTSL1 TMPRSS2 NCKAP5 ARAP2	2.06e-04	188	69	4	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 BNC2 ADAMTS1 ADAM22	2.06e-04	188	69	4	293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	HLA-C SLCO2A1 WNT2B EMILIN3	2.06e-04	188	69	4	fe7143c36e4a883745862d3c3147cf751b440e46
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAMTSL1 FCGBP LRRC3B TMPRSS2	2.06e-04	188	69	4	0d86044bc340e3efb90d0022dd299873639d831c
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|343B / Donor, Lineage, Cell class and subclass (all cells)	HLA-C SLCO2A1 WNT2B EMILIN3	2.06e-04	188	69	4	cbf32b675a7cd0c808d5c9c22dfa7fa79fbe2437
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADAMTSL1 SNCAIP SLCO2A1 LHX6	2.11e-04	189	69	4	c121817ddad164e9cfe382c43d0cbc9215508d02
ToppCell	LV-14._Fibroblast_III\|World / Chamber and Cluster_Paper	BNC2 ADAMTS1 TRPS1 CREB3L2	2.11e-04	189	69	4	3922135d1f6fc768d71ba3b465585fead6ea68a8
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 BNC2 ADAMTS1 ADAM22	2.11e-04	189	69	4	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	Endothelial-A-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	ADAMTSL1 ADAMTS1 SLCO2A1 LHX6	2.11e-04	189	69	4	04b565855f58ca0f343904d04be657b66e109076
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLA-C HIPK1 ADGRE5 SF1	2.11e-04	189	69	4	0e8d1be3c406d1a393e18faccfe89116a8f82bcf
Drug	NcAg	PPIG EGF FBXO11	4.84e-07	6	67	3	CID002795122
Drug	6-azauridine	ADSS2 UCK2 UCK1 ADSS1	1.33e-06	28	67	4	CID000005901
Drug	Sparfosate	ADSS2 UCK2 UCK1 ADSS1	2.03e-06	31	67	4	CID000004312
Drug	AC1L7UE9	UCK2 UCK1	8.53e-06	2	67	2	CID000341622
Drug	benziodarone	ABCB11 ABCB4	8.53e-06	2	67	2	ctd:C058702
Drug	AC1LAPI9	ADSS2 ADSS1	8.53e-06	2	67	2	CID000472615
Drug	tasosartan	ABCB11 ABCB4	8.53e-06	2	67	2	ctd:C086167
Drug	tipranavir	ABCB11 ABCB4	8.53e-06	2	67	2	ctd:C107201
Drug	1-[butoxy(phenyl)methyl]piperidine	UCK2 UCK1	8.53e-06	2	67	2	CID000219169
Drug	AC1Q6S1T	ADSS2 UCK2 UCK1 ADSS1	1.31e-05	49	67	4	CID000000644
Drug	AC1L1BJ2	ADSS2 UCK2 UCK1 ADSS1	1.54e-05	51	67	4	CID000001460
Drug	glutarimide	EGF UCK2 UCK1	1.61e-05	17	67	3	CID000070726
Drug	Primaquine	EGF ABCB11 ABCB4	1.93e-05	18	67	3	ctd:D011319
Drug	alanosyl-AICOR	ADSS2 ADSS1	2.55e-05	3	67	2	CID000127520
Drug	phosphohydantocidin	ADSS2 ADSS1	2.55e-05	3	67	2	CID000446561
Drug	N-ethylglutamine	PPIG SLCO2A1 SLC25A16	2.68e-05	20	67	3	CID000228398
Drug	estradiol-17 beta-glucuronide	EGF ABCB11 ABCB4	3.60e-05	22	67	3	ctd:C025483
Drug	thioinosinic acid	ADSS2 ABCB4 ADSS1	4.14e-05	23	67	3	CID003034391
Drug	guanidinosuccinic acid	ADSS2 ADGRE5 ADSS1	4.14e-05	23	67	3	CID000097856
Drug	6-methoxypurine arabinoside	ADSS2 HLA-C ADSS1	4.72e-05	24	67	3	CID000124757
Drug	CPE-CTP	UCK2 UCK1	5.10e-05	4	67	2	CID000164056
Drug	fipexide	ABCB11 ABCB4	5.10e-05	4	67	2	ctd:C038628
Drug	TPPR-MP	ADSS2 ADSS1	5.10e-05	4	67	2	CID003036186
Drug	EUrd	UCK2 UCK1	5.10e-05	4	67	2	CID000176869
Drug	streptovitacin A	UCK2 UCK1	5.10e-05	4	67	2	CID000091467
Drug	latanoprost	SLCO2A1 ABCB11	5.10e-05	4	67	2	ctd:C072042
Drug	3-cyano-2,6-dihydroxypyridine	UCK2 UCK1	8.48e-05	5	67	2	CID000100608
Drug	5-mercaptodeoxyuridine	UCK2 UCK1	8.48e-05	5	67	2	CID000099529
Drug	epiallopregnanolone sulfate	ABCB11 ABCB4	8.48e-05	5	67	2	ctd:C579439
Drug	17beta-estradiol glucuronide	SLCO1C1 SLCO2A1 ABCB11	1.14e-04	32	67	3	CID000066424
Drug	2,5-dibenzylidenecyclopentanone	PPIG ADAMTS2	1.27e-04	6	67	2	CID000098039
Drug	uridine analog	UCK2 UCK1	1.27e-04	6	67	2	CID000473560
Drug	HPPR -MP	ADSS2 ADSS1	1.27e-04	6	67	2	CID000086479
Drug	cyclopentenyl uracil	UCK2 UCK1	1.27e-04	6	67	2	CID000128937
Drug	thioinosine	UCK2 UCK1 ABCB4	1.49e-04	35	67	3	CID000676166
Drug	5-benzyloxybenzyluracil	UCK2 UCK1	1.77e-04	7	67	2	CID000099314
Drug	BBAU	UCK2 UCK1	1.77e-04	7	67	2	CID000134111
Drug	Indocyanine Green	ABCB11 ABCB4	1.77e-04	7	67	2	ctd:D007208
Drug	hydantocidin	ADSS2 ADSS1	1.77e-04	7	67	2	CID000125429
Drug	cimetidine	PPIG EGF SLCO1C1 SLCO2A1 ABCB4	1.85e-04	179	67	5	CID000002756
Drug	CaLam	ABCB11 SLC25A16 ABCB4	2.06e-04	39	67	3	CID004126474
Drug	Gabrene	PPIG SLCO2A1 ADGRE5	2.23e-04	40	67	3	CID005361323
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A	IGHMBP2 TMPRSS2 ZNF227 ADAM22 CREB3L2	2.27e-04	187	67	5	6978_UP
Drug	T beta-MC	ABCB11 ABCB4	2.36e-04	8	67	2	CID000168408
Drug	N3UDP	UCK2 UCK1	2.36e-04	8	67	2	CID000169817
Drug	L-alanosine	ADSS2 ABCB4 ADSS1	2.40e-04	41	67	3	CID000022128
Drug	TTNPB; Up 200; 0.1uM; MCF7; HG-U133A	TCEA2 ABCA4 TLR2 TMPRSS2 ADAM22	2.44e-04	190	67	5	223_UP
Drug	Diclofenac	EGF DNAJC10 SLCO2A1 DNAJA2 TLR2 ABCB11 UCK2 ABCB4	2.62e-04	570	67	8	ctd:D004008
Drug	Boldine [476-70-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A	SLCO2A1 IGHMBP2 TLR2 CUL7 ADAM22	2.62e-04	193	67	5	4122_UP
Drug	troglitazone; Up 200; 10uM; MCF7; HT_HG-U133A	ADAMTS20 TMPRSS2 ADGRE5 CUL7 ITPR1	2.68e-04	194	67	5	5229_UP
Drug	0317956-0000 [391210-11-0]; Up 200; 10uM; MCF7; HT_HG-U133A	SNCAIP HIPK1 TMPRSS2 CUL7 ADAM22	2.68e-04	194	67	5	3855_UP
Drug	Beta-Escin [11072-93-8]; Up 200; 3.2uM; MCF7; HT_HG-U133A	SNCAIP IL21R TLR2 ADAM22 ITPR1	2.75e-04	195	67	5	3890_UP
Drug	Aminopurine, 6-benzyl [1214-39-7]; Down 200; 17.8uM; MCF7; HT_HG-U133A	SLCO2A1 TMPRSS2 ZNF227 LHX6 ITPR1	2.75e-04	195	67	5	2313_DN
Drug	Cephapirin sodium salt [24356-60-3]; Down 200; 9uM; MCF7; HT_HG-U133A	MICALL2 IGHMBP2 TMPRSS2 ADGRE5 ZNF227	2.81e-04	196	67	5	3471_DN
Drug	Homatropine hydrobromide (R,S) [51-56-9]; Up 200; 11.2uM; MCF7; HT_HG-U133A	CENPO TMPRSS2 FBXO11 ZNF227 ITPR1	2.81e-04	196	67	5	1684_UP
Drug	SB 203580; Down 200; 1uM; MCF7; HT_HG-U133A	MICALL2 IGHMBP2 CENPO TMPRSS2 ADGRE5	2.81e-04	196	67	5	6899_DN
Drug	Clebopride maleate [84370-95-6]; Up 200; 8.2uM; PC3; HT_HG-U133A	IGHMBP2 ABCB11 FBXO11 MUC5B ZNF227	2.88e-04	197	67	5	6311_UP
Drug	Sulfadiazine [68-35-9]; Down 200; 16uM; PC3; HT_HG-U133A	EGF ADAMTS1 TRPS1 ZNF227 ARAP2	2.88e-04	197	67	5	5098_DN
Drug	Mevalonic-D, L acid lactone [674-26-0]; Up 200; 30.8uM; MCF7; HT_HG-U133A	TMPRSS2 CUL7 LHX6 ADAM22 ITPR1	2.88e-04	197	67	5	3459_UP
Drug	Ampyrone [83-07-8]; Up 200; 19.6uM; MCF7; HT_HG-U133A	ADAMTS12 SLCO2A1 WNT2B ADGRE5 ITPR1	2.88e-04	197	67	5	2249_UP
Drug	troglitazone; Up 200; 10uM; MCF7; HT_HG-U133A	EGF TLR2 CUL7 ADAM22 ITPR1	2.95e-04	198	67	5	5592_UP
Drug	celecoxib; Up 200; 10uM; MCF7; HG-U133A	BNC2 IGHMBP2 LHX6 SF1 ADAM22	2.95e-04	198	67	5	206_UP
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SLCO2A1 IGHMBP2 FBXO11 CUL7 ITPR1	2.95e-04	198	67	5	3882_DN
Drug	Chlorpropamide [94-20-2]; Down 200; 14.4uM; MCF7; HT_HG-U133A	IGHMBP2 TMPRSS2 FBXO11 ZNF227 ARAP2	2.95e-04	198	67	5	5391_DN
Drug	5-benzyluracil	UCK2 UCK1	3.03e-04	9	67	2	CID000236212
Drug	S 37	UCK2 UCK1	3.03e-04	9	67	2	CID000046875
Drug	N-hydroxyglycine	ADSS2 ADSS1	3.03e-04	9	67	2	CID000019070
Drug	4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid	ABCB11 ABCB4	3.03e-04	9	67	2	ctd:C000598200
Drug	oxybutynin	ABCB11 ABCB4	3.03e-04	9	67	2	ctd:C005419
Drug	EM-FU	UCK2 UCK1	3.03e-04	9	67	2	CID000124352
Drug	WAY-362450	ABCB11 ABCB4	3.03e-04	9	67	2	ctd:C540004
Drug	Bbb acyclonucleoside	UCK2 UCK1	3.03e-04	9	67	2	CID003025732
Disease	body fat distribution	PCSK5 BNC2 ADAMTSL1 MICALL2 ADAMTS2 WNT2B CREB3L2	4.32e-07	202	68	7	EFO_0004341
Disease	urinary tract obstruction (implicated_via_orthology)	BNC2 ADAMTS1	5.23e-06	2	68	2	DOID:5200 (implicated_via_orthology)
Disease	Progressive intrahepatic cholestasis (disorder)	ABCB11 ABCB4	1.57e-05	3	68	2	C0268312
Disease	Cholestasis, benign recurrent intrahepatic 1	ABCB11 ABCB4	1.57e-05	3	68	2	C4551899
Disease	Progressive familial intrahepatic cholestasis type 3	ABCB11 ABCB4	1.57e-05	3	68	2	cv:C1865643
Disease	sarcoma (biomarker_via_orthology)	ADSS2 ADSS1	1.57e-05	3	68	2	DOID:1115 (biomarker_via_orthology)
Disease	intrahepatic cholestasis (is_implicated_in)	ABCB11 ABCB4	3.13e-05	4	68	2	DOID:1852 (is_implicated_in)
Disease	Cholestasis, progressive familial intrahepatic 1	ABCB11 ABCB4	3.13e-05	4	68	2	C4551898
Disease	Colorectal Neoplasms	ABCA4 LRRC3B SLCO2A1 TLR2 ABCB11 ABCB4	4.36e-05	277	68	6	C0009404
Disease	endodermal sinus tumor (is_marker_for)	WNT2B SALL4	5.21e-05	5	68	2	DOID:1911 (is_marker_for)
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	PCSK5 TRPS1 ABCB11 CREB3L2	9.25e-05	102	68	4	EFO_0004329, EFO_0004611
Disease	Cholestasis of pregnancy	ABCB11 ABCB4	1.45e-04	8	68	2	C0268318
Disease	Ventricular Septal Defects	PCSK5 SALL4	1.45e-04	8	68	2	C0018818
Disease	cystic fibrosis (implicated_via_orthology)	ABCB11 ABCB4	1.86e-04	9	68	2	DOID:1485 (implicated_via_orthology)
Disease	cholestasis (implicated_via_orthology)	ABCB11 ABCB4	1.86e-04	9	68	2	DOID:13580 (implicated_via_orthology)
Disease	age at onset, multiple sclerosis	PCSK5 NCKAP5	2.33e-04	10	68	2	EFO_0004847, MONDO_0005301
Disease	otitis media (is_marker_for)	TLR2 MUC5B	2.33e-04	10	68	2	DOID:10754 (is_marker_for)
Disease	skin pigmentation measurement	ADAMTS12 BNC2 TRPS1 USH2A	2.88e-04	137	68	4	EFO_0007009
Disease	lung non-small cell carcinoma (is_implicated_in)	EGF XPO5 FBXO11 CHRNA5	3.04e-04	139	68	4	DOID:3908 (is_implicated_in)
Disease	diffuse plaque measurement	PCSK5 ADAMTSL1 SLCO2A1 FBXO11 SALL4 CUL7 SLC25A16 LHX6	3.47e-04	758	68	8	EFO_0010699
Disease	actinic keratosis	BNC2 TRPS1	4.68e-04	14	68	2	EFO_0002496
Disease	squamous cell carcinoma	ADAMTS12 BNC2 TRPS1	5.05e-04	67	68	3	EFO_0000707
Disease	amyotrophic lateral sclerosis, age at onset	PCSK5 ARAP2	5.39e-04	15	68	2	EFO_0004847, MONDO_0004976
Disease	sinusitis (is_marker_for)	TLR2 MUC5B	7.82e-04	18	68	2	DOID:0050127 (is_marker_for)
Disease	skin aging measurement	BNC2 TRPS1 CHRNA5 ARAP2	8.21e-04	181	68	4	EFO_0008006
Disease	basal cell carcinoma	ADAMTS12 BNC2 HLA-C TRPS1	9.64e-04	189	68	4	EFO_0004193
Disease	unipolar depression, bipolar disorder, schizophrenia	PCSK5 ADAMTS2	9.68e-04	20	68	2	EFO_0003761, MONDO_0004985, MONDO_0005090
Disease	Drug toxicity	HLA-C SLCO2A1 TLR2	9.76e-04	84	68	3	C0013221
Disease	Adverse reaction to drug	HLA-C SLCO2A1 TLR2	9.76e-04	84	68	3	C0041755
Disease	intraocular pressure measurement	PCSK5 ABCA4 ADSS2 ADAMTS2 WNT2B ADAMTS20	1.13e-03	509	68	6	EFO_0004695
Disease	otitis media (implicated_via_orthology)	FBXO11 SALL4	1.17e-03	22	68	2	DOID:10754 (implicated_via_orthology)
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	PCSK5 ABCB11 CREB3L2	1.57e-03	99	68	3	EFO_0004611, EFO_0007878
Disease	pancreatic cancer (is_marker_for)	EGF UCK2 ADGRE5	1.66e-03	101	68	3	DOID:1793 (is_marker_for)
Disease	Bone Diseases, Developmental	PCSK5 TRPS1	1.77e-03	27	68	2	C0005941
Disease	FEV/FEC ratio	PCSK5 BNC2 FCGBP ADAMTS2 ADAMTS1 TRPS1 CHRNA5 ARAP2 ITPR1	1.97e-03	1228	68	9	EFO_0004713

Protein segments in the cluster

Peptide	Gene	Start	Entry
GTRGLSCKNKTCGTI	C2orf42	36	Q9NWW7
KGSEGTCSCSSKGFS	ABCA4	1171	P78363
SSLSGSNGGIMCNIC	BNC2	1026	Q6ZN30
EGCQVLGSKNGSTTC	ADGRE5	511	P48960
SSKEGTICSGNGVCS	ADAM22	681	Q9P0K1
FVGSSGCGKSTSIQL	ABCB11	1111	O95342
CLSFVGCSTSGTNSG	ARAP2	216	Q8WZ64
CSTSCGLGVSTRISN	CCN4	226	O95388
DLCSTSCGGGFQKRT	ADAMTS12	1481	P58397
GVCGGDNSSCKTITG	ADAMTS20	711	P59510
GSCSRTCGTGVKFRT	ADAMTS2	571	O95450
LAGGIAGCCAKTTVA	SLC25A16	41	P16260
GAVCSCTGGKLSCLG	MUC5B	771	Q9HC84
LSCLGASLQKSTGCA	MUC5B	781	Q9HC84
NIPCGTTGTTCSKAI	MUC5B	941	Q9HC84
CTGTSGGVLVCQTKH	ADAMTS1	511	Q9UHI8
VCGGNGSTCKKISGS	ADAMTS1	716	Q9UHI8
LSVAGCGSCLEGSAQ	HAGHL	136	Q6PII5
TLQFLDCICGSTTGG	ITPR1	2011	Q14643
TKPVASVSGQSSGCC	HIPK1	1011	Q86Z02
TACSSSCGGGIQSRA	ADAMTSL1	386	Q8N6G6
GSLVSSTCGVCGKHV	MICALL2	181	Q8IY33
KSSGGKGGSCSQAAC	HLA-C	336	P10321
LTCSSSGTCTTCQKG	PCSK5	1426	Q92824
GKGSACSSTDVLSCI	CUL7	1611	Q14999
SVPSAGKNICSSCGL	LHX6	61	Q9UPM6
KGCLCSSSGGLNVTC	LRRC3B	36	Q96PB8
SGQTVALVGSSGCGK	ABCB4	421	P21439
RCLCTGEKGTGKSTQ	PPIG	41	Q13427
VLCSACSGQGGKSGA	DNAJA2	141	O60884
VSATGSKGNRTDSCC	CHRNA5	221	P30532
GSVLERDGKTCSGCS	EGF	426	P01133
STCTVGSAVCVSGQG	FBXO11	381	Q86XK2
SLGCVAVGSSTCQAS	FCGBP	1241	Q9Y6R7
GSLGCVAVGSTTCQA	FCGBP	2441	Q9Y6R7
GGSLGCVAVGSTTCQ	FCGBP	3641	Q9Y6R7
SDNCGGKVLSITGCS	MARF1	536	Q9Y4F3
GKSFCLSSVGTQTSG	ASNSD1	151	Q9NWL6
GGVGKTTCSCSLAVQ	GET3	46	O43681
LSSACCGLSSGQKSS	KRTAP10-3	206	P60369
SGCKSACCVTGLGTS	KRTAP29-1	301	A8MX34
TGLSGKLTSRGVCVC	CENPO	111	Q9BU64
AGTTVLSCGCVSAGS	IL21R	421	Q9HBE5
SQLQGLSVSGRGSCC	EMILIN3	371	Q9NT22
ITFCSKGGDCLTSQT	DNAJC10	261	Q8IXB1
GCTRCGKNFSSASAL	SALL4	871	Q9UJQ4
SRTCKLAGTQTGTCL	CREB3L2	366	Q70SY1
LCNSVGCVTSASGAG	USH2A	1446	O75445
YALQACTSGGCSTSK	USH2A	4331	O75445
LVACTNGGCTASVSK	USH2A	4421	O75445
TSSNCTVGGVCTGLG	ADSS1	271	Q8N142
SASLTCTLCSGINVG	IGLV5-45	36	A0A087WSX0
LKGSSQGSCLIGSSI	NCKAP5	1646	O14513
SGQCTCKLGVTGLTC	NTN5	291	Q8WTR8
CTTINGLSGKACSTG	SNCAIP	181	Q9Y6H5
SSNCTVGGVCTGLGM	ADSS2	271	P30520
LETCCSSELKGGGSG	RNF169	526	Q8NCN4
TVRKSGQCSGCGKTI	PRORP	341	O15091
NCSCVTGGSASAKTG	SLCO2A1	491	Q92959
GSGVFCANCLTTKTS	TRPS1	891	Q9UHF7
SKCSNSGIECDSSGT	TMPRSS2	111	O15393
IGVSGGTASGKSTVC	UCK1	26	Q9HA47
TCGFAKCTAGVTTLG	IGHMBP2	896	P38935
CGVCGKCFGKSSTLT	ZNF672	201	Q499Z4
CTCVGIAASKSGNSS	SLCO1C1	521	Q9NYB5
SCSAVGTGEGSLCSV	XPO5	481	Q9HAV4
SGGTASGKSSVCAKI	UCK2	26	Q9BZX2
CSGGASTAGKRSCLN	UBR3	1471	Q6ZT12
CDSCGKGFSSSTGLI	ZNF227	326	Q86WZ6
TGGTQTDLFTCGKCR	TCEA2	251	Q15560
GRKASSCSTSLSGCQ	ZNF354A	331	O60765
ASLSCDRNGICKGSS	TLR2	26	O60603
RSITNTTVCTKCGGA	SF1	271	Q15637
TTVCTKCGGAGHIAS	SF1	276	Q15637
AGRVCSKTSKGTDGC	WNT2B	321	Q93097
GQCGTKGDTTALCRS	ZAN	1771	Q9Y493
CGICGKGFTQSSVLS	ZNF784	226	Q8NCA9