Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	protein localization to M-band	ANK2 OBSCN	7.50e-06	2	57	2	GO:0036309
GeneOntologyBiologicalProcess	cellular response to camptothecin	BLM SPIDR	7.46e-05	5	57	2	GO:0072757
GeneOntologyBiologicalProcess	response to camptothecin	BLM SPIDR	7.46e-05	5	57	2	GO:1901563
GeneOntologyBiologicalProcess	negative regulation of mitotic recombination	BLM MLH1	7.46e-05	5	57	2	GO:0045950
Domain	-	RGS21 RGS1 RGS16	3.98e-05	22	57	3	1.10.196.10
Domain	RGS_subdom1	RGS21 RGS1 RGS16	3.98e-05	22	57	3	IPR024066
Domain	RGS	RGS21 RGS1 RGS16	1.65e-04	35	57	3	PF00615
Domain	RGS	RGS21 RGS1 RGS16	1.65e-04	35	57	3	SM00315
Domain	RGS	RGS21 RGS1 RGS16	1.79e-04	36	57	3	PS50132
Domain	RGS	RGS21 RGS1 RGS16	2.28e-04	39	57	3	IPR016137
Domain	FN3_dom	MPL FNDC5 OBSCN IFNLR1 IFNAR2	4.37e-04	209	57	5	IPR003961
Domain	Tissue_fac	IFNLR1 IFNAR2	5.92e-04	12	57	2	PF01108
Domain	Tissue_factor	IFNLR1 IFNAR2	5.92e-04	12	57	2	IPR001187
Domain	PH	PLEK2 ADAP1 PLEKHG4 OBSCN PLEKHH2	6.61e-04	229	57	5	PF00169
Domain	PH	PLEK2 ADAP1 PLEKHG4 OBSCN PLEKHH2	1.57e-03	278	57	5	SM00233
Domain	PH_DOMAIN	PLEK2 ADAP1 PLEKHG4 OBSCN PLEKHH2	1.59e-03	279	57	5	PS50003
Domain	PH_domain	PLEK2 ADAP1 PLEKHG4 OBSCN PLEKHH2	1.62e-03	280	57	5	IPR001849
Domain	FN3	MPL FNDC5 OBSCN IFNLR1	3.18e-03	199	57	4	PS50853
Domain	CRAL-TRIO_dom	PLEKHG4 SEC14L5	3.29e-03	28	57	2	IPR001251
Domain	KRAB	ZNF570 ZNF420 ZNF565 ZNF568 ZNF829	4.66e-03	358	57	5	PS50805
Domain	KRAB	ZNF570 ZNF420 ZNF565 ZNF568 ZNF829	4.66e-03	358	57	5	PF01352
Domain	DNA/RNA_helicase_DEAH_CS	BLM DHX29	5.10e-03	35	57	2	IPR002464
Domain	KRAB	ZNF570 ZNF420 ZNF565 ZNF568 ZNF829	5.29e-03	369	57	5	SM00349
Domain	KRAB	ZNF570 ZNF420 ZNF565 ZNF568 ZNF829	5.35e-03	370	57	5	IPR001909
Domain	DEAH_ATP_HELICASE	BLM DHX29	6.00e-03	38	57	2	PS00690
Domain	GDS_CDC24_CS	PLEKHG4 OBSCN	6.31e-03	39	57	2	IPR001331
Domain	-	PLEK2 ADAP1 PLEKHG4 OBSCN PLEKHH2	6.73e-03	391	57	5	2.30.29.30
Pathway	REACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR	BLM EME1 SPIDR RAD17	3.62e-05	70	38	4	M27570
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES	BLM EME1 SPIDR	1.11e-04	35	38	3	MM15293
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES	BLM EME1 SPIDR	1.32e-04	37	38	3	M27583
Pathway	REACTOME_HOMOLOGY_DIRECTED_REPAIR	BLM EME1 SPIDR RAD17	2.59e-04	116	38	4	MM15294
Pathway	REACTOME_DISEASES_OF_DNA_REPAIR	BLM MLH1 RAD17	3.44e-04	51	38	3	M29854
Pathway	REACTOME_HOMOLOGY_DIRECTED_REPAIR	BLM EME1 SPIDR RAD17	5.29e-04	140	38	4	M27584
Pathway	REACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR	BLM EME1 SPIDR	5.29e-04	59	38	3	MM15283
Pathway	REACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR	BLM EME1 SPIDR RAD17	6.20e-04	146	38	4	MM15292
Pubmed	SPIDR is required for homologous recombination during mammalian meiosis.	BLM MLH1 SPIDR	1.24e-06	13	58	3	36938872
Pubmed	The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair.	BLM MLH1	2.73e-06	2	58	2	11325959
Pubmed	Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1.	BLM MLH1	2.73e-06	2	58	2	11691925
Pubmed	Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles.	ANK2 OBSCN	8.19e-06	3	58	2	12527750
Pubmed	Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line.	ANK2 OBSCN	8.19e-06	3	58	2	18782775
Pubmed	Role of Functional IFNL4, IFNLR1, IFNA, IFNAR2 Polymorphisms in Hepatitis B virus-related liver disease in Han Chinese population.	IFNLR1 IFNAR2	1.64e-05	4	58	2	29080269
Pubmed	Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha.	BLM MLH1	1.64e-05	4	58	2	11470874
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	MLF2 PLEKHG4 WDR20 MLH1 SPIDR REEP4 DHX29 ZNF568 IFNAR2	2.12e-05	925	58	9	28986522
Pubmed	Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.	BLM EME1 MLH1	2.32e-05	33	58	3	19714462
Pubmed	MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16.	RGS1 RGS16	2.72e-05	5	58	2	10760272
Pubmed	Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair.	BLM MLH1	2.72e-05	5	58	2	19015241
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	ZCCHC14 NSMF ANK2 MYCBP2 ASF1B OBSCN FGA MLH1 MAP3K15 IFNLR1	2.96e-05	1215	58	10	15146197
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	BLM MLF2 RAB3GAP1 ANK2 MYCBP2 PWP2 TTC17 CRYBG3 REEP4 PPP6R2 DHX29	3.01e-05	1487	58	11	33957083
Pubmed	A retinal-specific regulator of G-protein signaling interacts with Galpha(o) and accelerates an expressed metabotropic glutamate receptor 6 cascade.	RGS1 RGS16	4.08e-05	6	58	2	15215290
Pubmed	Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.	RGS1 RGS16	4.08e-05	6	58	2	18434541
Pubmed	Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.	RGS1 RGS16	5.71e-05	7	58	2	10747990
Pubmed	Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.	BLM MLH1	5.71e-05	7	58	2	21240188
Pubmed	Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.	BLM SPIDR	1.22e-04	10	58	2	23509288
Pubmed	SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.	BLM MLH1	1.49e-04	11	58	2	11877377
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	BLM MLF2 RAB3GAP1 MYCBP2 MARCHF5 PWP2 FGA TTC17 MTARC2 CRYBG3	1.67e-04	1496	58	10	32877691
Pubmed	USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation.	MYCBP2 DYNC1H1	1.78e-04	12	58	2	29293652
Pubmed	A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.	BLM MLH1	1.78e-04	12	58	2	12724401
Pubmed	BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.	BLM MLH1	1.78e-04	12	58	2	10783165
Pubmed	Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence.	MLH1 RAD17	2.11e-04	13	58	2	19213844
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	RAB3GAP1 WDR20 PWP2 OBSCN IFFO2 MTARC2 SMOX ZNF829	2.80e-04	1021	58	8	26760575
Pubmed	Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis.	BLM MLH1	3.23e-04	16	58	2	17696610
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	BLM MLF2 MTMR14 MYCBP2 WDR20 MLH1 CRYBG3 PPP6R2	3.36e-04	1049	58	8	27880917
Pubmed	Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.	RGS1 RGS16	3.66e-04	17	58	2	20627871
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	BLM MLF2 NSMF KMT2A	4.25e-04	210	58	4	16565220
Pubmed	A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes.	RGS1 RGS16	4.59e-04	19	58	2	11342430
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZCCHC14 MTMR14 MYCBP2 OBSCN ICE1 DYNC1H1 IFNLR1 RGS16	4.74e-04	1105	58	8	35748872
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	MTMR14 IFFO1 IFFO2 TTC17 ZNF565 PPP6R2 DYNC1H1	5.28e-04	853	58	7	28718761
Pubmed	Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.	MLH1 DYNC1H1	6.76e-04	23	58	2	36973253
Pubmed	Exploring the link between MORF4L1 and risk of breast cancer.	BLM MLH1	7.37e-04	24	58	2	21466675
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	BLM MYCBP2 PWP2 DHX29 RPS6KC1	8.37e-04	440	58	5	34244565
Pubmed	Same but different - Molecular comparison of human KTI12 and PSTK.	RAB3GAP1 CRYBG3	9.34e-04	27	58	2	33417976
Pubmed	Decoding type I and III interferon signalling during viral infection.	IFNLR1 IFNAR2	9.34e-04	27	58	2	30936491
Pubmed	Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria.	MARCHF5 MTARC2	1.00e-03	28	58	2	28057766
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NSMF ANK2 OTOF MYCBP2 NAP1L3 TTC17 ZNF565 DYNC1H1	1.26e-03	1285	58	8	35914814
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	MLF2 ANK2 MTMR14 MYCBP2 OBSCN	1.44e-03	497	58	5	23414517
Cytoband	19q13.12	ZNF570 ZNF420 ZNF565 ZNF568 ZNF829	3.54e-08	72	58	5	19q13.12
Cytoband	1q42.13	OBSCN JMJD4	1.78e-03	49	58	2	1q42.13
Cytoband	1q41	MTARC2 RPS6KC1	3.19e-03	66	58	2	1q41
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	RGS21 RGS1	4.10e-03	75	58	2	chr1q31
GeneFamily	Intermediate filament family orphans	IFFO1 IFFO2	5.27e-06	2	42	2	614
GeneFamily	Regulators of G-protein signaling	RGS21 RGS1 RGS16	1.51e-05	21	42	3	720
GeneFamily	Interferon receptors	IFNLR1 IFNAR2	5.24e-05	5	42	2	599
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEK2 ADAP1 PLEKHG4 PLEKHH2	1.31e-03	206	42	4	682
GeneFamily	Fibronectin type III domain containing	MPL FNDC5 OBSCN	6.06e-03	160	42	3	555
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG4 OBSCN	1.03e-02	66	42	2	722
Coexpression	NIKOLSKY_BREAST_CANCER_19Q13.1_AMPLICON	ZNF570 ZNF420 ZNF568 ZNF829	1.53e-07	22	58	4	M8692
Disease	Acute Cerebrovascular Accidents	ZCCHC14 ANK2 FGA SMOX	3.19e-06	54	55	4	C0751956
Disease	Cerebrovascular accident	ZCCHC14 ANK2 FGA SMOX	5.56e-06	62	55	4	C0038454
Disease	diffuse large B-cell lymphoma, multiple sclerosis	RGS21 RGS1	7.12e-05	7	55	2	EFO_0000403, MONDO_0005301
Disease	myelofibrosis (is_implicated_in)	MPL KMT2A	9.48e-05	8	55	2	DOID:4971 (is_implicated_in)
Disease	marginal zone B-cell lymphoma, multiple sclerosis	RGS21 RGS1	1.22e-04	9	55	2	EFO_1000630, MONDO_0005301
Disease	beta wave measurement	RGS21 RGS1	2.22e-04	12	55	2	EFO_0006871
Disease	blood pressure	RGS21 RGS1	7.69e-04	22	55	2	EFO_0004325
Disease	vasculitis	RGS21 RGS1	9.17e-04	24	55	2	EFO_0006803
Disease	pulmonary embolism	FGA RPS6KC1	9.96e-04	25	55	2	EFO_0003827
Disease	unipolar depression, depressive symptom measurement	PLEK2 KMT2A	1.08e-03	26	55	2	EFO_0003761, EFO_0007006
Disease	Acute monocytic leukemia	BLM KMT2A	1.08e-03	26	55	2	C0023465
Disease	neurodegenerative disease (implicated_via_orthology)	PRKAG3 TRPC5 DYNC1H1	2.53e-03	145	55	3	DOID:1289 (implicated_via_orthology)
Disease	Lymphoma	BLM MLH1	2.54e-03	40	55	2	C0024299
Disease	bitter beverage consumption measurement	ACVR2B ZNF568	2.80e-03	42	55	2	EFO_0010089

Protein segments in the cluster

Peptide	Gene	Start	Entry
RNDTFEDTEDTWDSE	CRYBG3	1321	Q68DQ2
ATEFPATEAWECELE	PRKAG3	136	Q9UGI9
TECVEFLDWADARLT	ANKRD45	156	Q5TZF3
FACETESDQREWVAA	ADAP1	336	O75689
EESWENLVSDEDFSA	DHX29	521	Q7Z478
VDCLWRESTEVFARD	NWD2	1686	Q9ULI1
DSWSDSEEEFFECLS	RAB3GAP1	576	Q15042
TDWVDPSFDDFLECS	RAD17	16	O75943
EFSEENIEFWLACED	RGS1	106	Q08116
DSDSWSEIREDDEAF	ANK2	3041	Q01484
TLTFCWESSPEEEEE	IFNLR1	471	Q8IU57
WADVEDVTEEDCALR	MTMR14	171	Q8NCE2
WSEVEDSCDSDAIER	RPS6KC1	951	Q96S38
VCFATDEDDRTAEWV	MARCHF5	16	Q9NX47
CTLDEAFEDLDWDTE	NSMF	316	Q6X4W1
WEAKVEEVDRSCDSD	PLEKHH2	856	Q8IVE3
SFCDLTDEWRSTHEA	IFNAR2	91	P48551
EDDCDSLTWEETEET	IFFO1	416	Q0D2I5
DAEATEEGWASFSCE	OBSCN	2566	Q5VST9
SFSCELSHEDEEVEW	OBSCN	2576	Q5VST9
ISFECSEALADDLEW	ASF1B	26	Q9NVP2
EETLGTCEEWIESEE	ICE1	1226	Q9Y2F5
DDSEWLSSDVICIDD	BLM	226	P54132
FELRTSGEKCDEDAW	EFCAB7	431	A8K855
ELCAVQEEVSEWRDS	JMJD4	346	Q9H9V9
VVTGCDAFEEDTWDE	MTARC2	241	Q969Z3
TFDFDDDCDSLTWEE	IFFO2	371	Q5TF58
DDCDSLTWEENEDTL	IFFO2	376	Q5TF58
STFDRDADQWEENCA	FGA	786	P02671
DLRSACDTVDTWLDD	DYNC1H1	4211	Q14204
VNCALWSAEVFEDDD	KMT2A	1901	Q03164
LRDETTFSFCLESDW	EME1	451	Q96AY2
EDWTCFEQSASLDIR	SEC14L5	121	O43304
EDIWEDSDTRCAARV	PPP6R2	636	O75170
ESEAAAFDDEWRRET	MLF2	186	Q15773
ENCEDVADFDETFRW	OTOF	36	Q9HC10
LQDSDTEDECWSDTE	REEP4	191	Q9H6H4
TEDECWSDTEAVPRA	REEP4	196	Q9H6H4
DCKDDTSRDSAIEWY	MAP3K15	376	Q6ZN16
SEFSEENVEFWLACE	RGS21	41	Q2M5E4
DFDKIWREHCEDEET	BMT2	56	Q1RMZ1
CSFRDAWEEEEPASQ	PLEKHG4	26	Q58EX7
TTRSCALWDLEEDTE	FNDC5	86	Q8NAU1
EFCESDEGEAWSLAR	MYCBP2	2646	O75592
ECEWNSEDEEFSSDE	NAP1L3	161	Q99457
GEDDLVTVWSFVDCR	WDR20	281	Q8TBZ3
ATEVNWDEEKECFES	MLH1	661	P40692
TIEECWDHDAEARLS	ACVR2B	456	Q13705
ACSREERDAWAFEIT	PLEK2	86	Q9NYT0
KCSDLEGSDFRADWE	ZNF565	146	Q8N9K5
AWCSQESALSEEEED	ZNF568	26	Q3ZCX4
IDWEIDSDRAEASDC	SPIDR	126	Q14159
ETTCIDWTDDSRCFV	PWP2	146	Q15269
DEDEQWSVVVECEDC	SMOX	306	Q9NWM0
EFSEENLEFWLACEE	RGS16	86	O15492
FSRTFEDLTCFWDEE	MPL	41	P40238
EDLTCFWDEEEAAPS	MPL	46	P40238
DCRSEDDEATEWITF	TTC17	826	Q96AE7
SIDFSQEEWECLDAD	ZNF829	41	Q3KNS6
DRNVECSFEVLWSDS	ZCCHC14	111	Q8WYQ9
FRDVAVDFSQEEWDC	ZNF570	16	Q96NI8
VAIDFSQEEWECLDS	ZNF420	11	Q8TAQ5
DSSEDVFETWGEACD	TRPC5	941	Q9UL62