Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncomplement component C3b binding

CFH CFHR5 CR1

3.18e-05121073GO:0001851
GeneOntologyMolecularFunctionopsonin binding

CFH CFHR5 CR1

3.16e-04251073GO:0001846
GeneOntologyMolecularFunctionintegrin binding

ADAM15 ADAMTS13 ITGB3 SVEP1 THBS1 EGFR

3.62e-041751076GO:0005178
GeneOntologyMolecularFunctionfibrinogen binding

ITGB3 THBS1

4.21e-0461072GO:0070051
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAM15 ADAMTS13 ADAMTS10 ADAMTS7 ADAMTS20

4.70e-041201075GO:0004222
GeneOntologyMolecularFunctioncomplement binding

CFH CFHR5 CR1

6.63e-04321073GO:0001848
GeneOntologyMolecularFunctioncalcium ion binding

ESYT1 ADAMTS13 CD320 SVEP1 JAG2 THBS1 GJB2 CAMKK2 MEGF8 LRP2 LTBP2 FBN3

6.75e-0474910712GO:0005509
GeneOntologyMolecularFunctioninterleukin-17 receptor activity

IL17REL IL17RC

7.80e-0481072GO:0030368
GeneOntologyMolecularFunctionvirus receptor activity

MRC1 CR1 ITGB3 EGFR

1.13e-03851074GO:0001618
GeneOntologyMolecularFunctioncargo receptor activity

MRC1 CD320 ABCA7 LRP2

1.13e-03851074GO:0038024
GeneOntologyMolecularFunctionexogenous protein binding

MRC1 CR1 ITGB3 EGFR

1.18e-03861074GO:0140272
GeneOntologyMolecularFunctionRNA polymerase II CTD heptapeptide repeat kinase activity

CDK12 CDK13

1.24e-03101072GO:0008353
GeneOntologyMolecularFunctiongrowth factor binding

ITGB3 THBS1 EGFR LRP2 LTBP2

1.53e-031561075GO:0019838
GeneOntologyMolecularFunctionmonosaccharide binding

SIGLEC12 MRC1 PFKM SIGLEC7

1.71e-03951074GO:0048029
GeneOntologyMolecularFunctioninsulin-like growth factor I binding

ITGB3 LRP2

2.13e-03131072GO:0031994
GeneOntologyBiologicalProcessapoptotic cell clearance

XKR6 ITGB3 ABCA7 THBS1 PEAR1

4.90e-06481075GO:0043277
GeneOntologyBiologicalProcessnegative regulation of complement activation, classical pathway

CR1 SVEP1 C4BPB

7.46e-0681073GO:0045959
GeneOntologyBiologicalProcessblood coagulation

CFH FLNA ADAMTS13 ITGB3 SVEP1 F13B THBS1 C4BPB PEAR1

8.56e-062601079GO:0007596
GeneOntologyBiologicalProcesscoagulation

CFH FLNA ADAMTS13 ITGB3 SVEP1 F13B THBS1 C4BPB PEAR1

1.03e-052661079GO:0050817
GeneOntologyBiologicalProcesshemostasis

CFH FLNA ADAMTS13 ITGB3 SVEP1 F13B THBS1 C4BPB PEAR1

1.09e-052681079GO:0007599
GeneOntologyBiologicalProcessregulation of complement activation

CFH CR1 SVEP1 C4BPB

1.10e-05271074GO:0030449
GeneOntologyBiologicalProcessregulation of complement activation, classical pathway

CR1 SVEP1 C4BPB

1.59e-05101073GO:0030450
GeneOntologyBiologicalProcessnegative regulation of humoral immune response mediated by circulating immunoglobulin

CR1 SVEP1 C4BPB

2.89e-05121073GO:0002924
GeneOntologyBiologicalProcessphagocytosis, engulfment

SIGLEC12 XKR6 ABCA7 THBS1 SIGLEC7

2.95e-05691075GO:0006911
GeneOntologyBiologicalProcesscomplement activation

CFH CFHR5 CR1 SVEP1 C4BPB

3.17e-05701075GO:0006956
GeneOntologyBiologicalProcessnegative regulation of complement activation

CR1 SVEP1 C4BPB

4.74e-05141073GO:0045916
GeneOntologyBiologicalProcesspositive regulation of platelet activation

FLNA SVEP1 PEAR1

4.74e-05141073GO:0010572
GeneOntologyBiologicalProcessplasma membrane invagination

SIGLEC12 XKR6 ABCA7 THBS1 SIGLEC7

5.34e-05781075GO:0099024
GeneOntologyBiologicalProcessengulfment of apoptotic cell

XKR6 ABCA7 THBS1

5.90e-05151073GO:0043652
GeneOntologyBiologicalProcessnegative regulation of B cell mediated immunity

CR1 SVEP1 C4BPB

7.24e-05161073GO:0002713
GeneOntologyBiologicalProcessnegative regulation of immunoglobulin mediated immune response

CR1 SVEP1 C4BPB

7.24e-05161073GO:0002890
GeneOntologyBiologicalProcessblood coagulation, fibrin clot formation

FLNA ITGB3 F13B

8.75e-05171073GO:0072378
GeneOntologyBiologicalProcessanimal organ morphogenesis

TSPAN12 CFH FLNA ADAM15 NTN3 DVL3 LAMC2 LAMC3 AHDC1 PGR JAG2 THBS1 MEGF8 EGFR PKD1 LRP2 RELT MEGF11

8.81e-05126910718GO:0009887
GeneOntologyBiologicalProcessmembrane invagination

SIGLEC12 XKR6 ABCA7 THBS1 SIGLEC7

9.01e-05871075GO:0010324
GeneOntologyBiologicalProcessphagocytosis

SIGLEC12 XKR6 ITGB3 ABCA7 THBS1 SIGLEC7 C4BPB PEAR1

9.17e-052741078GO:0006909
GeneOntologyBiologicalProcessendocytosis

SIGLEC12 MRC1 XKR6 CD320 ITGB3 ABCA7 THBS1 SIGLEC7 STON2 LRP2 RAB11FIP5 C4BPB ARHGAP27 PEAR1

9.51e-0582710714GO:0006897
GeneOntologyBiologicalProcessregulation of body fluid levels

CFH FLNA ADAMTS13 ITGB3 SVEP1 F13B THBS1 EGFR C4BPB PEAR1

1.02e-0444210710GO:0050878
GeneOntologyBiologicalProcesscomplement activation, alternative pathway

CFH CFHR5 CR1

1.24e-04191073GO:0006957
GeneOntologyBiologicalProcessnegative regulation of humoral immune response

CR1 SVEP1 C4BPB

1.24e-04191073GO:0002921
GeneOntologyBiologicalProcessplatelet activation

CFH FLNA ADAMTS13 ITGB3 SVEP1 PEAR1

1.76e-041581076GO:0030168
GeneOntologyBiologicalProcessregulation of humoral immune response mediated by circulating immunoglobulin

CR1 SVEP1 C4BPB

1.95e-04221073GO:0002923
GeneOntologyBiologicalProcessprotein activation cascade

FLNA ITGB3 F13B

2.54e-04241073GO:0072376
GeneOntologyBiologicalProcessregulation of phagocytosis, engulfment

SIGLEC12 ABCA7 SIGLEC7

2.54e-04241073GO:0060099
GeneOntologyBiologicalProcessnegative regulation of phagocytosis, engulfment

SIGLEC12 SIGLEC7

2.64e-0451072GO:0060101
GeneOntologyBiologicalProcessnatural killer cell differentiation involved in immune response

PGLYRP1 ZNF683

2.64e-0451072GO:0002325
GeneOntologyBiologicalProcessregulation of natural killer cell differentiation involved in immune response

PGLYRP1 ZNF683

2.64e-0451072GO:0032826
GeneOntologyBiologicalProcessregulation of humoral immune response

CFH CR1 SVEP1 C4BPB

2.67e-04601074GO:0002920
GeneOntologyBiologicalProcessregulation of membrane invagination

SIGLEC12 ABCA7 SIGLEC7

2.87e-04251073GO:1905153
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

FLNA DVL3 PLXNB2 ITGB3 PGR JAG2 MEGF8 EGFR PKD1 LRP2 KDF1

3.72e-0461910711GO:0002009
GeneOntologyBiologicalProcessnegative regulation of membrane invagination

SIGLEC12 SIGLEC7

3.95e-0461072GO:1905154
GeneOntologyBiologicalProcessactivation of membrane attack complex

CFH CR1

3.95e-0461072GO:0001905
GeneOntologyBiologicalProcesshomotypic cell-cell adhesion

CFH FLNA ITGB3 MEGF11 PEAR1

4.72e-041241075GO:0034109
GeneOntologyBiologicalProcesstissue morphogenesis

FLNA DVL3 PLXNB2 ITGB3 AHDC1 PGR JAG2 MEGF8 EGFR PKD1 LRP2 KDF1

5.14e-0475010712GO:0048729
GeneOntologyBiologicalProcessregulation of complement activation, alternative pathway

CFH CR1

5.50e-0471072GO:0030451
GeneOntologyBiologicalProcessapolipoprotein A-I-mediated signaling pathway

ITGB3 ABCA7

5.50e-0471072GO:0038027
GeneOntologyBiologicalProcessgap junction-mediated intercellular transport

GJA8 GJB2

5.50e-0471072GO:1990349
GeneOntologyCellularComponentcell surface

SIGLEC12 CFH MRC1 ISLR2 UPK1A ADAM15 IL17RC ADAMTS13 CR1 PLXNB2 ADGRA2 ITGB3 ABCA7 THBS1 SIGLEC7 EGFR ADAMTS7 PKD1 LRP2 SCART1

7.89e-07111110720GO:0009986
GeneOntologyCellularComponentextracellular matrix

NTN3 LAMC2 LAMC3 ADAMTS13 PLXNB2 SSPOP SVEP1 ADAMTS10 THBS1 FCGBP ADAMTS7 ADAMTS20 LTBP2 FBN3

6.45e-0665610714GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

NTN3 LAMC2 LAMC3 ADAMTS13 PLXNB2 SSPOP SVEP1 ADAMTS10 THBS1 FCGBP ADAMTS7 ADAMTS20 LTBP2 FBN3

6.68e-0665810714GO:0030312
GeneOntologyCellularComponentruffle membrane

PSD ITGB3 ABCA7 EGFR PSD4

2.35e-041081075GO:0032587
MousePhenopetechiae

ITGB3 MEGF8 EGFR

3.34e-0511843MP:0008816
MousePhenoabnormal cilary zonule morphology

ADAMTS10 LTBP2

3.57e-052842MP:0014176
MousePhenoabnormal blood vessel morphology

TSPAN12 CFH FLNA ADAM15 PFKM CD320 CR1 ADGRA2 ITGB3 AHDC1 LACTB PGR THBS1 GJB2 MEGF8 EGFR ADAMTS7 SETD5 CDK13 PKD1 LRP2 SLC14A2

4.00e-0514728422MP:0001614
MousePhenoheart left ventricle hypertrophy

PFKM ITGB3 EGFR PKD1 LRP2

4.32e-0565845MP:0002625
MousePhenoabnormal epidermal-dermal junction morphology

LAMC2 AHDC1 ADAMTS10

4.43e-0512843MP:0011159
MousePhenoabnormal uvea morphology

CFH FLNA ADAM15 ESYT1 TYR ADAMTS10 GJA8 LTBP2

9.80e-05241848MP:0005197
MousePhenoabnormal kidney morphology

CFH PHRF1 DVL3 KCP LAMC2 IL17RC CR1 PLXNB2 ITGB3 ABCA7 TYR GJA8 THBS1 MEGF8 EGFR SETD5 CDK13 PKD1 LRP2 SLC14A2

1.27e-0413638420MP:0002135
MousePhenolethality during fetal growth through weaning, complete penetrance

FLNA SPEG DVL3 LAMC2 CHD4 CR1 ADGRA2 AHDC1 JAG2 TYR GJB2 MEGF8 EGFR SETD5 CDK13 HES7 PKD1 LRP2 KDF1

1.50e-0412698419MP:0011111
MousePhenoabnormal cardiac outflow tract development

FLNA DVL3 MEGF8 SETD5 PKD1 LRP2

1.53e-04134846MP:0006126
MousePhenoabnormal snout morphology

DVL3 AHDC1 MEGF8 EGFR SETD5 CDK13 LRP2 KDF1

1.53e-04257848MP:0000443
MousePhenolethality throughout fetal growth and development, complete penetrance

FLNA CR1 ADGRA2 GJB2 MEGF8 SETD5 CDK13 PKD1

1.79e-04263848MP:0011099
MousePhenoabnormal anterior uvea morphology

CFH FLNA ESYT1 TYR ADAMTS10 GJA8 LTBP2

1.91e-04199847MP:0005194
MousePhenoskin detachment

LAMC2 AHDC1

2.12e-044842MP:0009827
MousePhenosmall snout

DVL3 AHDC1 MEGF8 EGFR LRP2 KDF1

2.26e-04144846MP:0030190
MousePhenoabnormal cardiovascular development

FLNA SPEG DVL3 CHD4 PFKM ADGRA2 ITGB3 AHDC1 THBS1 MEGF8 ADAMTS7 SETD5 PKD1 LRP2

2.79e-048028414MP:0002925
MousePhenoomphalocele

FLNA AHDC1 MEGF8 LRP2

2.84e-0453844MP:0003052
MousePhenoabnormal jaw morphology

ESYT1 DVL3 LAMC2 JAG2 GJB2 MEGF8 EGFR SETD5 PKD1 LRP2 RELT

3.18e-045308411MP:0000454
MousePhenoabnormal heart left ventricle wall morphology

PFKM ITGB3 EGFR PKD1 LRP2

3.19e-0499845MP:0031533
MousePhenocleft palate

FLNA ADGRA2 JAG2 MEGF8 EGFR CDK13 LRP2 KDF1

3.39e-04289848MP:0000111
MousePhenoabnormal pulse pressure

THBS1 EGFR

3.53e-045842MP:0003882
MousePhenooral cleft

FLNA ADGRA2 JAG2 MEGF8 EGFR CDK13 LRP2 KDF1

3.55e-04291848MP:0021164
MousePhenoabnormal heart ventricle wall morphology

SPEG CHD4 PFKM ITGB3 EGFR CDK13 PKD1 LRP2

3.98e-04296848MP:0031532
DomainEGF_1

ADAM15 NTN3 LAMC2 LAMC3 SSPOP ITGB3 SVEP1 JAG2 THBS1 MEGF8 LRP2 LTBP2 MEGF11 FBN3 PEAR1

1.32e-1125510515PS00022
DomainEGF_2

ADAM15 NTN3 LAMC2 LAMC3 SSPOP ITGB3 SVEP1 JAG2 THBS1 MEGF8 LRP2 LTBP2 MEGF11 FBN3 PEAR1

2.28e-1126510515PS01186
DomainEGF-like_CS

ADAM15 NTN3 LAMC2 LAMC3 ITGB3 SVEP1 JAG2 THBS1 MEGF8 LRP2 LTBP2 MEGF11 FBN3 PEAR1

2.26e-1026110514IPR013032
DomainEGF

ADAM15 LAMC2 LAMC3 SVEP1 JAG2 THBS1 FCGBP MEGF8 LRP2 LTBP2 MEGF11 FBN3 PEAR1

7.13e-1023510513SM00181
DomainEGF-like_dom

ADAM15 LAMC2 LAMC3 SVEP1 JAG2 THBS1 FCGBP MEGF8 LRP2 LTBP2 MEGF11 FBN3 PEAR1

1.45e-0924910513IPR000742
DomainSushi

CFH CFHR5 CSMD2 CR1 SVEP1 F13B C4BPB

1.58e-08521057PF00084
DomainGrowth_fac_rcpt_

NTN3 LAMC2 LAMC3 SVEP1 JAG2 MEGF8 EGFR LRP2 LTBP2 FBN3

1.81e-0815610510IPR009030
DomainCCP

CFH CFHR5 CSMD2 CR1 SVEP1 F13B C4BPB

2.07e-08541057SM00032
DomainSUSHI

CFH CFHR5 CSMD2 CR1 SVEP1 F13B C4BPB

2.68e-08561057PS50923
DomainSushi_SCR_CCP_dom

CFH CFHR5 CSMD2 CR1 SVEP1 F13B C4BPB

3.04e-08571057IPR000436
DomainLaminin_EGF

NTN3 LAMC2 LAMC3 MEGF8 MEGF11 PEAR1

3.89e-08351056PF00053
DomainEGF_Lam

NTN3 LAMC2 LAMC3 MEGF8 MEGF11 PEAR1

3.89e-08351056SM00180
DomainEGF_extracell

ADAM15 ITGB3 SVEP1 JAG2 LRP2 LTBP2 MEGF11

4.38e-08601057IPR013111
DomainEGF_2

ADAM15 ITGB3 SVEP1 JAG2 LRP2 LTBP2 MEGF11

4.38e-08601057PF07974
DomainLaminin_EGF

NTN3 LAMC2 LAMC3 MEGF8 MEGF11 PEAR1

6.52e-08381056IPR002049
DomainEGF_3

ADAM15 SSPOP SVEP1 JAG2 THBS1 MEGF8 LRP2 LTBP2 MEGF11 FBN3 PEAR1

8.73e-0823510511PS50026
DomainEGF_CA

SVEP1 JAG2 THBS1 MEGF8 LRP2 LTBP2 FBN3

5.41e-07861057PF07645
DomainTIL_dom

KCP SSPOP FCGBP LRP2

9.04e-07141054IPR002919
DomainTSP_1

ADAMTS13 SSPOP ADAMTS10 THBS1 ADAMTS7 ADAMTS20

1.43e-06631056PF00090
DomainTSP1

ADAMTS13 SSPOP ADAMTS10 THBS1 ADAMTS7 ADAMTS20

1.73e-06651056SM00209
DomainTSP1_rpt

ADAMTS13 SSPOP ADAMTS10 THBS1 ADAMTS7 ADAMTS20

1.73e-06651056IPR000884
DomainTSP1

ADAMTS13 SSPOP ADAMTS10 THBS1 ADAMTS7 ADAMTS20

1.73e-06651056PS50092
DomainVWC

KCP SSPOP JAG2 THBS1 FCGBP

2.21e-06381055SM00214
DomainDISINTEGRIN_1

ADAM15 ADAMTS13 ADAMTS10 ADAMTS7 ADAMTS20

2.87e-06401055PS00427
DomainReprolysin

ADAM15 ADAMTS13 ADAMTS10 ADAMTS7 ADAMTS20

2.87e-06401055PF01421
DomainADAM_MEPRO

ADAM15 ADAMTS13 ADAMTS10 ADAMTS7 ADAMTS20

2.87e-06401055PS50215
DomainDISINTEGRIN_2

ADAM15 ADAMTS13 ADAMTS10 ADAMTS7 ADAMTS20

2.87e-06401055PS50214
DomainPeptidase_M12B

ADAM15 ADAMTS13 ADAMTS10 ADAMTS7 ADAMTS20

2.87e-06401055IPR001590
DomainDisintegrin_dom

ADAM15 ADAMTS13 ADAMTS10 ADAMTS7 ADAMTS20

3.26e-06411055IPR001762
DomainVWC_out

KCP SSPOP JAG2 FCGBP

3.43e-06191054SM00215
DomainVWF_dom

KCP SSPOP JAG2 THBS1 FCGBP

3.68e-06421055IPR001007
DomainEGF_CA

SVEP1 JAG2 THBS1 MEGF8 LRP2 LTBP2 FBN3

5.72e-061221057SM00179
DomainEGF-like_Ca-bd_dom

SVEP1 JAG2 THBS1 MEGF8 LRP2 LTBP2 FBN3

6.37e-061241057IPR001881
DomainPeptidase_M12B_ADAM-TS

ADAMTS13 ADAMTS10 ADAMTS7 ADAMTS20

9.19e-06241054IPR013273
DomainhEGF

SVEP1 JAG2 MEGF11 FBN3

1.74e-05281054PF12661
DomainEGF_Ca-bd_CS

SVEP1 JAG2 MEGF8 LRP2 LTBP2 FBN3

1.79e-05971056IPR018097
DomainEGF_CA

SVEP1 JAG2 MEGF8 LRP2 LTBP2 FBN3

2.01e-05991056PS01187
DomainASX_HYDROXYL

SVEP1 JAG2 MEGF8 LRP2 LTBP2 FBN3

2.12e-051001056PS00010
DomainEGF_LAM_2

NTN3 LAMC2 LAMC3 MEGF8

2.31e-05301054PS50027
DomainEGF_LAM_1

NTN3 LAMC2 LAMC3 MEGF8

2.31e-05301054PS01248
DomainEGF-type_Asp/Asn_hydroxyl_site

SVEP1 JAG2 MEGF8 LRP2 LTBP2 FBN3

2.96e-051061056IPR000152
DomainUnchr_dom_Cys-rich

KCP SSPOP FCGBP

4.74e-05131053IPR014853
DomainC8

KCP SSPOP FCGBP

4.74e-05131053SM00832
DomainVWFC_1

KCP SSPOP JAG2 THBS1

4.84e-05361054PS01208
DomainVWFC_2

KCP SSPOP JAG2 THBS1

6.01e-05381054PS50184
DomainPeptidase_M12B_N

ADAM15 ADAMTS10 ADAMTS7 ADAMTS20

6.67e-05391054IPR002870
DomainPep_M12B_propep

ADAM15 ADAMTS10 ADAMTS7 ADAMTS20

6.67e-05391054PF01562
DomainEGF

ITGB3 SVEP1 JAG2 LRP2 LTBP2 FBN3

7.80e-051261056PF00008
DomainVWD

KCP SSPOP FCGBP

9.17e-05161053SM00216
DomainVWF_type-D

KCP SSPOP FCGBP

9.17e-05161053IPR001846
DomainVWFD

KCP SSPOP FCGBP

9.17e-05161053PS51233
DomainVWD

KCP SSPOP FCGBP

9.17e-05161053PF00094
DomainMetalloPept_cat_dom

ADAM15 ADAMTS13 ADAMTS10 ADAMTS7 ADAMTS20

9.31e-05811055IPR024079
Domain-

ADAM15 ADAMTS13 ADAMTS10 ADAMTS7 ADAMTS20

9.31e-058110553.40.390.10
DomainIL-17_rcpt_C/E_N

IL17REL IL17RC

9.36e-0531052IPR027841
DomainIL17_R_N

IL17REL IL17RC

9.36e-0531052PF15037
DomainEMI

SSPOP MEGF11 PEAR1

1.11e-04171053PS51041
DomainLDLRA_1

CD320 SSPOP PKD1 LRP2

1.52e-04481054PS01209
DomainLDLRA_2

CD320 SSPOP PKD1 LRP2

1.64e-04491054PS50068
DomainCUB

ADAMTS13 CSMD2 OVCH1 MEGF8

2.23e-04531054PS01180
DomainZINC_PROTEASE

ADAM15 ADAMTS13 ADAMTS10 ADAMTS7 ADAMTS20

2.29e-04981055PS00142
DomainADAM_spacer1

ADAMTS10 ADAMTS7 ADAMTS20

2.82e-04231053IPR010294
DomainADAM_spacer1

ADAMTS10 ADAMTS7 ADAMTS20

2.82e-04231053PF05986
DomainCUB_dom

ADAMTS13 CSMD2 OVCH1 MEGF8

2.96e-04571054IPR000859
DomainTB

LTBP2 FBN3

6.45e-0471052PF00683
DomainLAMININ_IVA

LAMC2 LAMC3

8.57e-0481052PS51115
DomainLaminin_B

LAMC2 LAMC3

8.57e-0481052PF00052
Domain-

LTBP2 FBN3

8.57e-04810523.90.290.10
DomainLamB

LAMC2 LAMC3

8.57e-0481052SM00281
DomainLaminin_IV

LAMC2 LAMC3

8.57e-0481052IPR000034
DomainGPS

ADGRA2 PKD1 ADGRD2

9.10e-04341053SM00303
DomainGPS

ADGRA2 PKD1 ADGRD2

9.91e-04351053PF01825
DomainGPS

ADGRA2 PKD1 ADGRD2

1.08e-03361053PS50221
DomainPH_dom-spectrin-type

PSD PSD4

1.10e-0391052IPR001605
DomainIntegin_beta_N

ITGB3 MEGF8

1.10e-0391052IPR033760
DomainTB

LTBP2 FBN3

1.10e-0391052PS51364
DomainTB_dom

LTBP2 FBN3

1.10e-0391052IPR017878
DomainPSI_integrin

ITGB3 MEGF8

1.10e-0391052PF17205
DomainGPS

ADGRA2 PKD1 ADGRD2

1.17e-03371053IPR000203
DomainZnf_FYVE_PHD

PHRF1 PHF7 CHD4 ZFYVE28 BAZ1A

1.45e-031471055IPR011011
DomainLDLR_class-A_CS

CD320 SSPOP LRP2

1.47e-03401053IPR023415
DomainPHD

PHRF1 PHF7 CHD4 BAZ1A

1.60e-03891054SM00249
DomainCys-rich_flank_reg_C

ISLR2 ADGRA2 PKD1 LRRN4

1.66e-03901054IPR000483
DomainLRRCT

ISLR2 ADGRA2 PKD1 LRRN4

1.66e-03901054SM00082
DomainPentaxin-related

SVEP1 ADGRD2

1.67e-03111052IPR001759
DomainPentaxin

SVEP1 ADGRD2

1.67e-03111052PF00354
DomainZnf_PHD

PHRF1 PHF7 CHD4 BAZ1A

1.73e-03911054IPR001965
DomainPept_M10_metallopeptidase

ADAM15 ADAMTS13 ADAMTS7

1.81e-03431053IPR001818
DomainPSI

PLXNB2 ITGB3 MEGF8

1.93e-03441053IPR016201
DomainTIL

SSPOP FCGBP

1.99e-03121052PF01826
DomainC8

SSPOP FCGBP

1.99e-03121052PF08742
DomainZF_PHD_2

PHRF1 PHF7 CHD4 BAZ1A

2.03e-03951054PS50016
DomainLdl_recept_a

CD320 SSPOP LRP2

2.06e-03451053PF00057
DomainZF_PHD_1

PHRF1 PHF7 CHD4 BAZ1A

2.11e-03961054PS01359
DomainPSI

PLXNB2 ITGB3 MEGF8

2.20e-03461053SM00423
Domain-

CD320 SSPOP LRP2

2.20e-034610534.10.400.10
DomainCUB

CSMD2 OVCH1 MEGF8

2.64e-03491053PF00431
DomainLDrepeatLR_classA_rpt

CD320 SSPOP LRP2

2.64e-03491053IPR002172
DomainLDLa

CD320 SSPOP LRP2

2.64e-03491053SM00192
DomainCUB

CSMD2 OVCH1 MEGF8

2.79e-03501053SM00042
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS13 SSPOP ADAMTS10 THBS1 ADAMTS7 ADAMTS20

3.77e-0839716M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS13 SSPOP ADAMTS10 THBS1 ADAMTS7 ADAMTS20

3.77e-0839716MM15165
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS13 SSPOP ADAMTS10 THBS1 ADAMTS7 ADAMTS20

1.13e-0668716M27303
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS13 SSPOP ADAMTS10 THBS1 ADAMTS7 ADAMTS20

1.77e-05109716MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS13 SSPOP ADAMTS10 THBS1 ADAMTS7 ADAMTS20

1.97e-05111716M27416
PathwayWP_FOCAL_ADHESION

FLNA LAMC2 LAMC3 ITGB3 THBS1 SHC2 EGFR

6.23e-05199717M39402
PathwayKEGG_FOCAL_ADHESION

FLNA LAMC2 LAMC3 ITGB3 THBS1 SHC2 EGFR

6.23e-05199717M7253
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS13 SSPOP ADAMTS10 THBS1 ADAMTS7 ADAMTS20

8.17e-05143716M27275
PathwayWP_COMPLEMENT_SYSTEM

CFH CR1 ITGB3 THBS1 LRP2

1.20e-0496715M39581
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

LAMC2 LAMC3 ITGB3 THBS1

2.18e-0459714M27218
PathwayKEGG_MEDICUS_REFERENCE_ALTERNATIVE_PATHWAY_OF_COMPLEMENT_CASCADE_C3B_BREAKDOWN

CFH CR1

2.48e-045712M47875
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS13 CD320 SSPOP ADAMTS10 THBS1 ADAMTS7 ADAMTS20

2.57e-04250717M27554
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FLNA LTBP2 FBN3

2.60e-0425713M39713
PathwayWP_FOCAL_ADHESION

FLNA LAMC2 LAMC3 ITGB3 THBS1 EGFR

3.52e-04187716MM15913
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR

CFH CFHR5

3.70e-046712M47880
PathwayKEGG_COMPLEMENT_AND_COAGULATION_CASCADES

CFH CR1 F13B C4BPB

3.99e-0469714M16894
PathwayREACTOME_TRANSPORT_OF_RCBL_WITHIN_THE_BODY

CD320 LRP2

5.17e-047712MM15703
PathwayWP_MAMMARY_GLAND_DEVELOPMENT_PREGNANCY_AND_LACTATION_STAGE_3_OF_4

PGR GJB2 EGFR

5.99e-0433713M39455
PathwayREACTOME_TRANSPORT_OF_RCBL_WITHIN_THE_BODY

CD320 LRP2

6.87e-048712M45025
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

ADAM15 LAMC2 LAMC3 ITGB3 THBS1 LTBP2 FBN3

7.65e-04300717M610
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

ITGB3 LTBP2 FBN3

8.41e-0437713M27134
PathwayKEGG_ECM_RECEPTOR_INTERACTION

LAMC2 LAMC3 ITGB3 THBS1

8.41e-0484714M7098
PathwayWP_BREAST_CANCER_PATHWAY

DVL3 PGR JAG2 SHC2 EGFR

1.06e-03154715M39739
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FLNA CDK12 ESYT1 SPEG OBSCN LAMC3 PLXNB2 ADGRA2 ABCA7 AHDC1 PPP1R26 JAG2 NHSL1 TMEM129 MEGF8 ADAMTS7 SETD5 CDK13 CCDC3 PKD1

2.29e-1011051092035748872
Pubmed

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.

ADAMTS13 ADAMTS10 ADAMTS7 ADAMTS20

4.43e-0812109425770910
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS13 SSPOP ADAMTS10 THBS1 ADAMTS7 ADAMTS20

1.39e-0775109620637190
Pubmed

The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration.

CFH CFHR5 F13B

5.95e-076109318541031
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

FLNA RNF19A LAMC2 FAM131A CHD4 AHDC1 TMEM129 THBS1 SETD5

1.09e-06332109937433992
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

CFH ADAMTS13 ITGB3 F13B THBS1 FCGBP MEGF8 C4BPB

1.59e-06257109816335952
Pubmed

Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.

CFH CFHR5 CR1 C4BPB

2.69e-0631109419344414
Pubmed

Analysis of the Tropism of SARS-CoV-2 Based on the Host Interactome of the Spike Protein.

FLNA LAMC2 THBS1 EGFR

2.69e-0631109437939376
Pubmed

ADAMTS: a novel family of extracellular matrix proteases.

ADAMTS13 ADAMTS10 ADAMTS7

3.54e-0610109311167130
Pubmed

Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease).

CFH CFHR5

9.73e-062109216299065
Pubmed

Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium.

CDK12 CDK13

9.73e-062109230319007
Pubmed

Silencing of LAMC2 Reverses Epithelial-Mesenchymal Transition and Inhibits Angiogenesis in Cholangiocarcinoma via Inactivation of the Epidermal Growth Factor Receptor Signaling Pathway.

LAMC2 EGFR

9.73e-062109231345467
Pubmed

FLNa negatively regulated proliferation and metastasis in lung adenocarcinoma A549 cells via suppression of EGFR.

FLNA EGFR

9.73e-062109229272322
Pubmed

Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.

CDK12 CDK13

9.73e-062109224999027
Pubmed

Role of TSP-1 and its receptor ITGB3 in the renal tubulointerstitial injury of focal segmental glomerulosclerosis.

ITGB3 THBS1

9.73e-062109238960036
Pubmed

Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence.

EGFR KLHDC8A

9.73e-062109220133782
Pubmed

Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells.

PGR EGFR

9.73e-062109226892043
Pubmed

Epidermal growth factor activates reproductive behavior independent of ovarian steroids in female rodents.

PGR EGFR

9.73e-062109210894157
Pubmed

Laminin-5γ-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration, and invasion by modulating signaling of EGFR.

LAMC2 EGFR

9.73e-062109224170107
Pubmed

Oncogenic Roles of Laminin Subunit Gamma-2 in Intrahepatic Cholangiocarcinoma via Promoting EGFR Translation.

LAMC2 EGFR

9.73e-062109238526177
Pubmed

Filamin A modulates kinase activation and intracellular trafficking of epidermal growth factor receptors in human melanoma cells.

FLNA EGFR

9.73e-062109219213840
Pubmed

Correlation between laminin-5 gamma2 chain and epidermal growth factor receptor expression in esophageal squamous cell carcinomas.

LAMC2 EGFR

9.73e-062109216103736
Pubmed

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.

CDK12 CDK13

9.73e-062109220952539
Pubmed

Assignment of complement components C4 binding protein (C4BP) and factor H (FH) to human chromosome 1q, using cDNA probes.

CFH CR1

9.73e-06210922977721
Pubmed

Factor H binds to washed human platelets.

CFH THBS1

9.73e-062109215634279
Pubmed

Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains.

ITGB3 EGFR

9.73e-062109228487468
Pubmed

Maternofetal transport of vitamin B12: role of TCblR/CD320 and megalin.

CD320 LRP2

9.73e-062109228351841
Pubmed

Homozygosity mapping of a Weill-Marchesani syndrome locus to chromosome 19p13.3-p13.2.

ADAMTS10 FBN3

9.73e-062109211941487
Pubmed

Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases.

SPEG OBSCN

9.73e-062109215185077
Pubmed

Localization of blood proteins thrombospondin1 and ADAMTS13 to cerebral corpora amylacea.

ADAMTS13 THBS1

9.73e-062109219422532
Pubmed

The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells.

MRC1 ADAMTS13

9.73e-062109222289891
Pubmed

Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing.

CDK12 CDK13

9.73e-062109225561469
Pubmed

MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer.

MIIP ITGB3

9.73e-062109236130933
Pubmed

Systemic antithrombotic effects of ADAMTS13.

ADAMTS13 ITGB3

9.73e-062109216533881
Pubmed

Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.

CDK12 CDK13

9.73e-062109235857807
Pubmed

The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous system.

CD320 LRP2

9.73e-062109223430977
Pubmed

[Correlation of serum ADAMTS13 and TSP1 levels with myocardial injury and prognosis in patients with acute coronary syndrome].

ADAMTS13 THBS1

9.73e-062109234134958
Pubmed

New genetic associations detected in a host response study to hepatitis B vaccine.

SIGLEC12 CFH KIF12 LAMC3 CFHR5 CR1 ITGB3 F13B JAG2 FCGBP SIGLEC7 C4BPB

1.11e-058241091220237496
Pubmed

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.

ADAM15 ZNF212 NTN3 OBSCN RTL10 FAM131A AHDC1 ADAMTS10 TMEM129 MEGF8 HES7 INAVA RELT

1.93e-0510211091326760575
Pubmed

Clinicopathological significance of MMP-7, laminin γ2 and EGFR expression at the invasive front of gastric carcinoma.

LAMC2 EGFR

2.91e-053109224048760
Pubmed

Immunoexpression of progesterone receptor, epithelial growth factor receptor and galectin-3 in uterine smooth muscle tumors.

PGR EGFR

2.91e-053109229729689
Pubmed

Thrombospondin-1 and ADAMTS13 competitively bind to VWF A2 and A3 domains in vitro.

ADAMTS13 THBS1

2.91e-053109220705333
Pubmed

Novel pathogenic variants and multiple molecular diagnoses in neurodevelopmental disorders.

CHD4 CDK13

2.91e-053109231238879
Pubmed

Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis.

GJA8 EGFR

2.91e-053109216611690
Pubmed

Gain-of-Function Mutation in Filamin A Potentiates Platelet Integrin αIIbβ3 Activation.

FLNA ITGB3

2.91e-053109228428218
Pubmed

ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers.

ADAM15 ADAMTS10

2.91e-053109215358598
Pubmed

LACTB promotes metastasis of nasopharyngeal carcinoma via activation of ERBB3/EGFR-ERK signaling resulting in unfavorable patient survival.

LACTB EGFR

2.91e-053109233152401
Pubmed

CR1, ABCA7, and APOE genes affect the features of cognitive impairment in Alzheimer's disease.

CR1 ABCA7

2.91e-053109224530172
Pubmed

Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains.

LAMC2 LAMC3

2.91e-053109218697739
Pubmed

β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.

ITGB3 EGFR

2.91e-053109221937717
Pubmed

Human neutrophil alpha-defensins induce formation of fibrinogen and thrombospondin-1 amyloid-like structures and activate platelets via glycoprotein IIb/IIIa.

ITGB3 THBS1

2.91e-053109222268819
Pubmed

ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1.

THBS1 ADAMTS7

2.91e-053109225712208
Pubmed

USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly.

PSD PSD4

2.91e-053109220339350
Pubmed

Identification of key proteins of cultured human intestinal cells involved in interaction with enteroaggregative Escherichia coli.

THBS1 EGFR

2.91e-053109222672426
Pubmed

An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin.

ITGB3 THBS1

2.91e-05310922478219
Pubmed

Thrombospondin-induced adhesion of human platelets.

ITGB3 THBS1

2.91e-05310922010551
Pubmed

A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.

CFH CR1

2.91e-05310923782802
Pubmed

Evaluating von Willebrand factor and ADAMTS13 levels in thalassemia major patients and assessing a possible association with Thrombospondin-1.

ADAMTS13 THBS1

2.91e-053109237438087
Pubmed

The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy.

CHD4 SETD5

2.91e-053109231474762
Pubmed

Human CMV infection of endothelial cells induces an angiogenic response through viral binding to EGF receptor and beta1 and beta3 integrins.

ITGB3 EGFR

2.91e-053109218375753
Pubmed

Structural mechanism of integrin inactivation by filamin.

FLNA ITGB3

2.91e-053109225849143
Pubmed

Thrombospondin-1 opens the paracellular pathway in pulmonary microvascular endothelia through EGFR/ErbB2 activation.

THBS1 EGFR

2.91e-053109221531776
Pubmed

Abnormal immune complex processing and spontaneous glomerulonephritis in complement factor H-deficient mice with human complement receptor 1 on erythrocytes.

CFH CR1

2.91e-053109220702729
Pubmed

Identification of residues within the 727-767 segment of human complement component C3 important for its interaction with factor H and with complement receptor 1 (CR1, CD35).

CFH CR1

2.91e-05310929988761
Pubmed

Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins.

GJA8 GJB2

2.91e-053109227143357
Pubmed

Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy.

CFH ADAMTS13

2.91e-053109231409673
Pubmed

Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia.

CFH C4BPB

2.91e-053109222514678
Pubmed

Factor H binds to platelet integrin alphaIIbbeta3.

CFH ITGB3

2.91e-053109218979363
Pubmed

HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells.

EGFR PKD1

2.91e-053109223152903
Pubmed

CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1.

CDK12 CDK13

2.91e-053109237026485
Pubmed

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.

CHD4 CDK13

2.91e-053109227479907
Pubmed

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.

ADGRA2 ITGB3 JAG2 THBS1

3.64e-0559109421421844
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ISLR2 CDK12 ZNF212 PHRF1 ADGRA2 TUBGCP6 ZFYVE28 CAMKK2 RAB11FIP5

4.52e-05529109914621295
Pubmed

A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing.

ITGB3 THBS1

5.82e-054109221224474
Pubmed

Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.

CFH CR1

5.82e-054109227165610
Pubmed

Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation-driven colorectal cancers.

SIGLEC12 SIGLEC7

5.82e-054109238990656
Pubmed

Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm.

SIGLEC12 SIGLEC7

5.82e-054109227494323
Pubmed

Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response.

SIGLEC12 SIGLEC7

5.82e-054109237460871
Pubmed

Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo.

SIGLEC12 SIGLEC7

5.82e-054109224391502
Pubmed

The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.

SIGLEC12 SIGLEC7

5.82e-054109238454157
Pubmed

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells.

SIGLEC12 SIGLEC7

5.82e-054109230130255
Pubmed

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood.

CR1 ITGB3

5.82e-054109236591264
Pubmed

Siglec receptors impact mammalian lifespan by modulating oxidative stress.

SIGLEC12 SIGLEC7

5.82e-054109225846707
Pubmed

Validating GWAS Variants from Microglial Genes Implicated in Alzheimer's Disease.

CR1 ABCA7

5.82e-054109228477215
Pubmed

An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.

ITGB3 EGFR

5.82e-054109224747441
Pubmed

Immunosuppressive Siglec-E ligands on mouse aorta are up-regulated by LPS via NF-κB pathway.

SIGLEC12 SIGLEC7

5.82e-054109231918287
Pubmed

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

CDK12 CDK13

5.82e-054109222012619
Pubmed

Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E).

SIGLEC12 SIGLEC7

5.82e-054109219552697
Pubmed

Targeting the Siglec-sialic acid axis promotes antitumor immune responses in preclinical models of glioblastoma.

SIGLEC12 SIGLEC7

5.82e-054109237467314
Pubmed

Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization.

SIGLEC12 SIGLEC7

5.82e-054109237492129
Pubmed

Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.

THBS1 LRP2

5.82e-05410927775583
Pubmed

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes.

ADAM15 ITGB3

5.82e-054109222505472
Pubmed

The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.

SIGLEC12 SIGLEC7

5.82e-054109233007530
Pubmed

Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E.

SIGLEC12 SIGLEC7

5.82e-054109227920204
Pubmed

Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E.

SIGLEC12 SIGLEC7

5.82e-054109221835922
Pubmed

Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity.

SIGLEC12 SIGLEC7

5.82e-054109234155121
Pubmed

Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation.

SIGLEC12 SIGLEC7

5.82e-054109232725371
Pubmed

Weill-Marchesani Syndrome

ADAMTS10 LTBP2

5.82e-054109220301293
Pubmed

Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing.

SIGLEC12 SIGLEC7

5.82e-054109230910970
Pubmed

Protective chromosome 1q32 haplotypes mitigate risk for age-related macular degeneration associated with the CFH-CFHR5 and ARMS2/HTRA1 loci.

CFH CFHR5

5.82e-054109234563268
Cytoband1q32

CFH CR1 C4BPB

2.22e-044910931q32
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CFH CFHR5 CSMD2 CR1 SVEP1 F13B C4BPB

2.66e-09577271179
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS13 ADAMTS10 ADAMTS7 ADAMTS20

8.56e-071972450
GeneFamilyComplement system|Sushi domain containing

CFH CFHR5 CR1

3.93e-0436723492
GeneFamilyPHD finger proteins

PHRF1 PHF7 CHD4 BAZ1A

4.56e-049072488
GeneFamilyLaminin subunits

LAMC2 LAMC3

1.01e-0312722626
GeneFamilyGap junction proteins

GJA8 GJB2

3.43e-0322722314
GeneFamilyCyclin dependent kinases

CDK12 CDK13

4.78e-0326722496
GeneFamilyCD molecules|C2-set domain containing|Sialic acid binding Ig like lectins

SIGLEC12 SIGLEC7

5.53e-0328722745
GeneFamilyCD molecules|Tetraspanins

TSPAN12 UPK1A

7.62e-0333722768
CoexpressionNABA_ECM_GLYCOPROTEINS

NTN3 KCP LAMC2 LAMC3 SSPOP SVEP1 THBS1 LTBP2 FBN3

1.36e-071961099M3008
CoexpressionNABA_MATRISOME

ADAM15 NTN3 KCP LAMC2 LAMC3 ADAMTS13 PLXNB2 SSPOP SVEP1 F13B ADAMTS10 THBS1 MEGF8 ADAMTS7 ADAMTS20 LTBP2 MEGF11 FBN3

2.32e-07102610918M5889
CoexpressionNABA_MATRISOME

ADAM15 NTN3 KCP LAMC2 LAMC3 ADAMTS13 PLXNB2 SSPOP SVEP1 F13B ADAMTS10 THBS1 MEGF8 ADAMTS7 ADAMTS20 LTBP2 MEGF11

9.00e-07100810917MM17056
CoexpressionNABA_ECM_GLYCOPROTEINS

NTN3 KCP LAMC2 LAMC3 SSPOP SVEP1 THBS1 LTBP2

1.39e-061911098MM17059
CoexpressionNABA_CORE_MATRISOME

NTN3 KCP LAMC2 LAMC3 SSPOP SVEP1 THBS1 LTBP2 FBN3

2.31e-062751099M5884
CoexpressionPRC1_BMI_UP.V1_DN

TSPAN12 UPK1A RNF19A ANKS1B LAMC3 ADAMTS7 PSD4

1.36e-051871097M2730
CoexpressionNABA_CORE_MATRISOME

NTN3 KCP LAMC2 LAMC3 SSPOP SVEP1 THBS1 LTBP2

1.77e-052701098MM17057
CoexpressionGSE36078_UNTREATED_VS_AD5_INF_MOUSE_LUNG_DC_UP

ADAM15 DVL3 PFKM GJA8 GJB2 ADAMTS7 C4BPB

2.09e-052001097M9289
CoexpressionPEREZ_TP53_TARGETS

PHRF1 OBSCN DVL3 RTL10 KCP ABCA7 AHDC1 JAG2 TUBGCP6 ZFYVE28 ADAMTS7 CCDC3 INAVA ARHGAP27 MEGF11 PEAR1

3.68e-05120110916M4391
CoexpressionNIKOLSKY_BREAST_CANCER_22Q13_AMPLICON

IL17REL PLXNB2 TUBGCP6

4.56e-05171093M12053
CoexpressionNABA_MATRISOME_PRIMARY_METASTATIC_COLORECTAL_TUMOR

PLXNB2 SVEP1 MEGF8 LTBP2

1.08e-04591094M47989
ToppCellParenchymal-10x3prime_v2-Stromal-Mesofibroblastic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CFH IL17RC CSMD2 KLHDC8A LTBP2 ZNF565 FASTKD3

5.86e-0719810970cd930e374c2c48d1991b51c025f9801b22ecee7
ToppCellParenchymal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CFH IL17RC CSMD2 KLHDC8A LTBP2 ZNF565 FASTKD3

5.86e-071981097e0df6d6ff2a9c41d813f84a2a5ee7cb5f6fc3e30
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CFH LAMC3 ADGRA2 SVEP1 PGR LTBP2 PEAR1

6.06e-071991097dfc5c7a4a093baa7158dd8d4d29a870d9c469a3f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CFH LAMC3 ADGRA2 SVEP1 PGR LTBP2 PEAR1

6.06e-071991097c1760581c34b81d1d92c67500a1c8944e9cc6dad
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

CHD4 CSMD2 SETD5 BAZ1A ADAMTS20 LRRN4

1.82e-061491096768877bade04ca0321593b8470b5011ad8270431
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA LAMC3 SVEP1 PGR KLHDC8A CCDC3

2.38e-061561096d5207dbfbcfb885557ea1378dfe6a56d7102e94a
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA LAMC3 SVEP1 PGR KLHDC8A CCDC3

2.38e-061561096363f1b661048d25895e2b8681c82894c957b29c0
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Col15a1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CFH LAMC3 SVEP1 THBS1 GJB2 PEAR1

2.66e-06159109634c90711c5857cf6ada7b3acff99f1d48c7caf29
ToppCellfacs-Heart-RV-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCP LAMC2 TMEM129 SHC2 EGFR CCDC3

3.91e-061701096d7c9a604311974ff87ece43a0f8725a234d262f7
ToppCellBronchial_Biopsy-Endothelial-Lymphatic|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

MRC1 ISLR2 ADGRA2 SSPOP SHC2 ADAMTS7

4.18e-061721096c41f5a66781bbf63afce7ca5d118cc6d8e0fe0bc
ToppCellAdult-Mesenchymal-pericyte_cell-D231|Adult / Lineage, Cell type, age group and donor

SPEG KCP LAMC3 ADGRA2 CCDC3 PEAR1

4.18e-061721096858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH GJB2 LRP2 ADAMTS20 C4BPB LRRN4

5.26e-061791096056df2aaff750e0e283e7da78fcc3c90c366aac0
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH GJB2 LRP2 ADAMTS20 C4BPB LRRN4

5.26e-061791096f5f3945ef3b9efc5921a71fd51deeb2c80f0ce11
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA SPEG LAMC3 ADGRA2 PGR CCDC3

5.97e-061831096667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

OBSCN KCP LAMC3 ADGRA2 CCDC3 PEAR1

6.96e-061881096ccddc08121caff958a2b6f9e278a018858af6b4d
ToppCellSubstantia_nigra-Endothelial|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CFH FLNA ESYT1 LAMC3 ADGRA2 PEAR1

7.18e-061891096bef8234bd9c4d6e3cdef0791d8066b39ba56ebba
ToppCellHippocampus-Endothelial|Hippocampus / BrainAtlas - Mouse McCarroll V32

CFH ESYT1 LAMC3 IL17RC ADGRA2 PEAR1

7.85e-06192109636deadab892d3e639a71f33697bb2d3cbbaa5372
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

CFH ANKS1B SVEP1 THBS1 EGFR LTBP2

8.33e-061941096d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH FLNA LAMC3 ADGRA2 SVEP1 CCDC3

8.58e-061951096edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH GJB2 LRP2 IGFL2 C4BPB LRRN4

8.83e-061961096147dc1ca5942df48a083cce39a9a7541430f8365
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA LAMC3 ADGRA2 SVEP1 CCDC3 LTBP2

8.83e-061961096fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA LAMC3 ADGRA2 SVEP1 CCDC3 LTBP2

8.83e-061961096802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH GJB2 LRP2 IGFL2 C4BPB LRRN4

8.83e-061961096ee89f6884aea11aefeaabe043db7f80145dcdf7f
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH GJB2 LRP2 IGFL2 C4BPB LRRN4

8.83e-061961096e75c36cb042342d69a593fb1ce62fab033889871
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FLNA SPEG ADGRA2 ADAMTS10 CCDC3 PEAR1

9.36e-0619810967dd874b09c81cc512ccc1e9b65f290a5f94d736e
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ISLR2 ADGRA2 ADAMTS10 HES7 IGFL2 LTBP2

9.36e-0619810967d2fe57e0f9311ac1e6854402ebc154306eb1ba5
ToppCellBronchial-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

OBSCN KCP LAMC3 ADGRA2 HES7 PEAR1

9.63e-061991096929f809579368201331d9099d8904b6e3c41797b
ToppCellBronchial-NucSeq-Stromal-Pericyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

OBSCN KCP LAMC3 ADGRA2 HES7 PEAR1

9.63e-061991096854628ce91068093c14bd4d45ba38c41469f3549
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-TYR-L2-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKS1B LAMC3 TYR EGFR KLHDC8A FBN3

9.91e-06200109604954fbe1e2264077228bb582c9a5897a70e6da2
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_2|Neuronal / cells hierarchy compared to all cells using T-Statistic

LAMC3 TYR EGFR KLHDC8A MEGF11 FBN3

9.91e-062001096913487e065dd580c9cbcbb3c3fc76a8d446f8856
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-TYR|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKS1B LAMC3 TYR EGFR KLHDC8A FBN3

9.91e-062001096bfdafb024a7b20d46837b2e6480dd4929253cd62
ToppCell(01)_IL1RL1+|World / shred by cell type by condition

FLNA LAMC2 JAG2 THBS1 GJB2 CCDC3

9.91e-062001096501420901bf3ec1b050e0d14596a9f9f3fdfc928
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CFH LAMC3 SVEP1 GJB2 PEAR1

5.84e-0516810959930bd63b60c03f0152838a79eef77da1c2dd8e5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH LAMC3 ADGRA2 SVEP1 PGR

5.84e-051681095d19a115365c5415e51c039718d7669de788fcf33
ToppCellCOVID-19_Severe-CD4+_CTL|World / disease group, cell group and cell class

CFH ISLR2 ZNF683 CD320 RAB11FIP5

6.01e-0516910958c8168ac93a808d7b4756e4491db2b2979df1c1f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH LAMC3 ADGRA2 SVEP1 PEAR1

6.01e-051691095a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCellfacs-Marrow-T-cells-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAM15 ESYT1 PLXNB2 CAMKK2

6.18e-051701095a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCellfacs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAM15 ESYT1 PLXNB2 CAMKK2

6.18e-051701095ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CFH LAMC3 ADGRA2 CCDC3 PEAR1

6.35e-051711095a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CFH LAMC3 SVEP1 GJB2 PEAR1

6.35e-0517110952e43fb129ee9bdc3b31febc43c10f959bf0f4a7d
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CFH LAMC3 SVEP1 GJB2 PEAR1

6.35e-051711095e219a1aa59a96e4bc3e2eacf985679174a51de41
ToppCelldroplet-Liver-nan-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LAMC2 LAMC3 JAG2 HES7

6.53e-0517210951f335ccb92b22d0412954e8fc3af212f96410b67
ToppCelldroplet-Liver-nan-3m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LAMC2 LAMC3 JAG2 HES7

6.53e-051721095bb96c896d125e10b71e94e2bdad243899045af5c
ToppCelldroplet-Marrow-nan-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH MRC1 PLXNB2 PPP1R26 TUBGCP6

6.71e-0517310956d2ceba4f89a228600e2b40aba81bb0eb81578c0
ToppCelldroplet-Thymus-nan-24m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH MRC1 ADAM15 PLXNB2 THBS1

6.89e-05174109544c21521991ad4789783d73d5aa4993a22876886
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CFH LAMC3 SVEP1 GJB2 PEAR1

6.89e-0517410952891ab2fd05eb4bbd239d1a2865f21ef7f2df39e
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CFH LAMC3 SVEP1 GJB2 PEAR1

6.89e-051741095eade55f86ef1f7a5355ad65cec3aa6bfc5d3c62d
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Dedifferentiated_Liposarcoma|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

CFH MRC1 CR1 SVEP1 C4BPB

7.08e-0517510952eca4c168dea2017ea0e383006e28abed22f32ec
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LAMC2 FAM131A JAG2 KLHDC8A C9orf50

7.08e-051751095711ace94fa9a763c6ae48171a690953f25deebe4
ToppCellNS-critical-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ADAM15 PHF7 ADGRA2 PGR STON2

7.28e-0517610957cf1a06ceee1ec06532f44c729c31b4d58e5ea49
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PSD PHF7 PGR ADAMTS10

7.28e-051761095b4a23d8d1414434adeb237a96f28c825f1aebd77
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PSD PHF7 PGR ADAMTS10

7.28e-05176109566c9c6b59030f67e8d746a9c6930e50923f2ded1
ToppCellCOVID-19_Severe-CD4+_CTL|COVID-19_Severe / disease group, cell group and cell class

CFH ISLR2 ZNF683 CD320 RAB11FIP5

7.47e-05177109534e9455790bae905dd91923792f4109d18b7686e
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ISLR2 LAMC3 EGFR MEGF11 SLC25A48

7.47e-0517710951cb78133ac09ea3a3f5b5de07151033998406512
ToppCellfacs-Brain_Myeloid-Striatum-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 ADGRA2 PPP1R26 ADAMTS10 RELT

7.47e-051771095f6b9d91d46830d0d207b0abd4ee5a4942fd99774
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CFH LAMC3 SVEP1 GJB2 PEAR1

7.47e-051771095599cf7f5b774e197a1b43c98e4b9a8c1a618f38a
ToppCellPND14-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FAM131A XKR6 ITGB3 THBS1 STON2

7.68e-05178109563f5880a5b514e20ef2c07a6a9cb8df34e6cede5
ToppCellPND14-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FAM131A XKR6 ITGB3 THBS1 STON2

7.68e-05178109582c84f8b8a7e6a3d3be3351b348a37143279c100
ToppCelldroplet-Fat-Scat-21m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN NHSL1 KLHDC8A LTBP2 INAVA

7.68e-0517810955fc9f41609735b972a2cd0830182d13742cd5bf5
ToppCellPND14-Immune-Immune_Myeloid-Megakaryocyte/Platelet|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FAM131A XKR6 ITGB3 THBS1 STON2

7.68e-051781095cb91558469ae0748106fb0b6d702edb0ff21a884
ToppCellfacs-Heart-RA-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UPK1A THBS1 INAVA KDF1 SLC25A48

8.30e-051811095c68d272eb41f81bd8ea4d0360733a2396bc87037
ToppCellfacs-Heart-RA-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UPK1A THBS1 INAVA KDF1 SLC25A48

8.30e-0518110955e5eb89f224ee48065a328ade030cbc4dcdcac12
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMC3 TYR EGFR KLHDC8A FBN3

8.30e-05181109535bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

ANKS1B CCDC3 LRP2 LTBP2 SLC25A48

8.30e-051811095c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCelldroplet-Thymus-nan-18m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF12 LAMC3 ADGRA2 MEGF8 KDF1

8.52e-051821095f6717e97e87513384149800c9fd8dea821ab9393
ToppCelldroplet-Thymus-nan-18m-Myeloid-professional_antigen_presenting_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF12 LAMC3 ADGRA2 MEGF8 KDF1

8.52e-051821095c33b0d532822186a1e8e645500347972468718c0
ToppCellAdult-Mesenchymal-pericyte_cell-D122|Adult / Lineage, Cell type, age group and donor

OBSCN KCP LAMC3 CCDC3 PEAR1

8.75e-051831095fc31a43a637423cb3bb9aa184a3a889a0b9aaea6
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ISLR2 LAMC3 EGFR MEGF11 SLC25A48

8.75e-0518310955e361be3ae3fe05098968e58427630127bd12675
ToppCell343B-Epithelial_cells-Epithelial-I_(AT1)|343B / Donor, Lineage, Cell class and subclass (all cells)

LAMC2 ABCA7 C4BPB LRRN4 FBN3

8.97e-051841095cb15d6bae52c5ec251c2235859dc7e65f630ae23
ToppCell343B-Epithelial_cells-Epithelial-I_(AT1)-|343B / Donor, Lineage, Cell class and subclass (all cells)

LAMC2 ABCA7 C4BPB LRRN4 FBN3

8.97e-051841095bde4eaabd3e9bdaed23867d23a919b9d84b52d4b
ToppCellfacs-Lung-EPCAM-24m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UPK1A LAMC2 LRP2 KDF1 SLC25A48

9.44e-0518610953c4994a1a7db06a61da8170e45e06aaef7896592
ToppCellfacs-Lung-EPCAM-24m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UPK1A LAMC2 LRP2 KDF1 SLC25A48

9.44e-051861095a583d6fc0f1e729f6e9fd18d7b49d6eab9ca32b9
ToppCellAdult-Mesenchymal-pericyte_cell|Adult / Lineage, Cell type, age group and donor

OBSCN KCP LAMC3 CCDC3 PEAR1

9.68e-05187109562759efb660179402fb574ce5701c89a2e17bcfe
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ISLR2 SVEP1 LRP2 LRRN4

9.68e-0518710954e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ISLR2 SVEP1 LRP2 LRRN4

9.68e-051871095d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ISLR2 SVEP1 LRP2 LRRN4

9.68e-051871095827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ISLR2 PGLYRP1 PRR23C ADAM15 JAG2

9.68e-05187109525efb82afe863a853ecdd781ad89026c993aaa67
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH THBS1 C9orf50 LTBP2 MEGF11

9.93e-051881095b382d18fb09fb2869f3c151efa71540a7f5ed229
ToppCellFrontal_cortex-Endothelial|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CFH ESYT1 IL17RC ADGRA2 PEAR1

9.93e-051881095a43392dbd10fc7dbfb31be39b8af8a7ea121c894
ToppCellCOVID-19-Heart-Fib_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

CFH ANKS1B SVEP1 EGFR LTBP2

9.93e-051881095fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

ISLR2 ADGRA2 ADAMTS10 LTBP2 PEAR1

9.93e-051881095c90669b51e1902fe7726555290c91c92a911df83
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH LAMC3 ADGRA2 SVEP1 PGR

1.02e-04189109571397e993a77d70b2eeede240bdfc7660b558987
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH LAMC3 ADGRA2 SVEP1 PGR

1.02e-0418910954eea4759520c312bd17a681034d8074e47093d2b
ToppCellGlobus_pallidus-Endothelial|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CFH ESYT1 IL17RC ADGRA2 PEAR1

1.02e-041891095ad7dc9d25edd68fb624380a082c389fe7d640e7d
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC2 THBS1 FCGBP LTBP2 KDF1

1.02e-0418910956f0fc5271a7d3682f145e734abc3be6473dda2e2
ToppCellStriatum-Endothelial|Striatum / BrainAtlas - Mouse McCarroll V32

CFH ESYT1 LAMC3 ADGRA2 PEAR1

1.02e-04189109595ee3b6d7fbbfcf91c780dfcd0926acec05f0a2d
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC2 THBS1 FCGBP LTBP2 KDF1

1.02e-0418910953b9ce8964b16cb2200d30cbb0bfc711dcad2380e
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC2 THBS1 FCGBP LTBP2 KDF1

1.02e-04189109538acb307907fde68b992057714448c1561d69ee3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG LAMC3 ADGRA2 SVEP1 CCDC3

1.04e-04190109570c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCelldroplet-Marrow-nan-24m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM15 ESYT1 PLXNB2 LACTB CAMKK2

1.04e-041901095e2fdbfaf08da3274b6bdda615386aa880040a90a
ToppCell10x5'v1-week_12-13-Endothelial-stroma-tip_EC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TSPAN12 JAG2 NHSL1 SHC2 KLHDC8A

1.07e-041911095cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH LAMC3 ADGRA2 SVEP1 PGR

1.07e-04191109539092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-3|TCGA-Ovary / Sample_Type by Project: Shred V9

RNF19A ITGB3 THBS1 GJB2 IGFL2

1.07e-04191109580d30d8eedb4c70b58440646325bc04c5700803e
ToppCellmetastatic_Lymph_Node-Fibroblasts-Myofibroblasts|metastatic_Lymph_Node / Location, Cell class and cell subclass

ISLR2 GJB2 CCDC3 IGFL2 LTBP2

1.07e-041911095aa43b472bc8362f79ae63f09f1ca764718bbf22c
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

CFH LAMC3 ADGRA2 CCDC3 PEAR1

1.07e-04191109578c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA JAG2 THBS1 LTBP2 INAVA

1.07e-0419110952f733d510a4862565a817f59829d8387d7ea26d9
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA JAG2 THBS1 LTBP2 INAVA

1.07e-0419110958691eba35793e4e90f93d50c2145847ee51289f7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH LAMC3 ADGRA2 SVEP1 PGR

1.07e-041911095ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFH CSMD2 GJB2 IGFL2 LTBP2

1.10e-04192109567e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CFH LAMC3 ADGRA2 CCDC3 PEAR1

1.10e-04192109509cb5b89a164ac7444774ccc8c90323c8ea2026b
DrugNefopam hydrochloride [23327-57-3]; Up 200; 13.8uM; MCF7; HT_HG-U133A

IL17RC ADGRA2 ITGB3 GJA8 THBS1 CAMKK2 SIGLEC7 ADAMTS7 ADAMTS20 SLC14A2

2.90e-08197106103627_UP
DrugColchicine [64-86-8]; Up 200; 10uM; MCF7; HT_HG-U133A

FLNA SPEG DVL3 PHF7 LAMC2 ADGRA2 ABCA7 MEGF8 PSD4

3.17e-0719410693213_UP
DrugPindolol [13523-86-9]; Up 200; 16.2uM; MCF7; HT_HG-U133A

MIIP CFH DBF4B ADAMTS13 ITGB3 KLHDC8A LTBP2 ADGRD2

3.98e-0619710682238_UP
DrugTheophylline monohydrate [5967-84-0]; Up 200; 20.2uM; MCF7; HT_HG-U133A

PGLYRP1 DVL3 LAMC3 IL17RC SVEP1 GJA8 SIGLEC7 KLHDC8A

4.13e-0619810683326_UP
DrugMianserine hydrochloride [21535-47-7]; Up 200; 13.2uM; MCF7; HT_HG-U133A

DBF4B SPEG FAM131A ADGRA2 ITGB3 SVEP1 PGR

2.96e-0518910672231_UP
DrugOxalamine citrate salt [1949-20-8]; Up 200; 9.2uM; MCF7; HT_HG-U133A

RNF19A DVL3 FAM131A ADGRA2 ITGB3 THBS1 C4BPB

3.39e-0519310673344_UP
Drug5707885; Up 200; 50uM; MCF7; HT_HG-U133A

ADAM15 LAMC3 IL17RC ADGRA2 SVEP1 F13B SIGLEC7

3.50e-0519410676385_UP
DrugIfenprodil tartrate [23210-58-4]; Down 200; 8.4uM; HL60; HT_HG-U133A

ADAM15 IL17RC CD320 ADGRA2 MEGF8 LRP2 LTBP2

3.74e-0519610672372_DN
DrugPiperacillin sodium salt [59703-84-3]; Up 200; 7.4uM; MCF7; HT_HG-U133A

PGLYRP1 DVL3 IL17RC CR1 ITGB3 SIGLEC7 ADAMTS7

3.86e-0519710673939_UP
DrugIndapamide [26807-65-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A

IL17RC CR1 ABCA7 PGR THBS1 CAMKK2 LRP2

3.86e-0519710673859_UP
Drug(+) -Levobunolol hydrochloride [47141-41-3]; Up 200; 12.2uM; MCF7; HT_HG-U133A

PGLYRP1 RNF19A LAMC2 ADAMTS13 CR1 ITGB3 ADAMTS7

3.86e-0519710673355_UP
DrugNSC-270916

CFH ADAMTS13 CFHR5 PGR EGFR

4.08e-05821065CID000002949
DrugFlecainide acetate [54143-56-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A

RNF19A SPEG SVEP1 PGR CAMKK2 SIGLEC7 CDK13

4.25e-0520010673418_UP
DrugOxymetazoline hydrochloride [2315-02-8]; Up 200; 13.4uM; MCF7; HT_HG-U133A

LAMC2 IL17RC CR1 ADGRA2 PGR LRP2 C4BPB

4.25e-0520010672278_UP
DrugGrgds

FLNA SPEG LAMC2 ITGB3 THBS1

4.33e-05831065CID000123811
DiseaseSushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 measurement

ADAM15 SVEP1 PEAR1

1.70e-0741043EFO_0803113
Diseasecortical surface area measurement

UPK1A ADAM15 LAMC3 XKR6 PLXNB2 ADGRA2 SVEP1 JAG2 TYR NHSL1 THBS1 EGFR ADAMTS7 CCDC3 PKD1 ADAMTS20 ARHGAP27 FBN3

1.03e-06134510418EFO_0010736
Diseaseatypical hemolytic-uremic syndrome (is_marker_for)

CFH ADAMTS13

3.68e-0531042DOID:0080301 (is_marker_for)
DiseaseWeill-Marchesani syndrome

ADAMTS10 LTBP2

3.68e-0531042C0265313
Diseasecomplement C5 measurement

CFHR5 F13B

3.68e-0531042EFO_0020278
Diseasethrombospondin type-1 domain-containing protein 7A measurement

CFH C4BPB

3.68e-0531042EFO_0803150
Diseaseplatelet-derived growth factor receptor alpha measurement

CFHR5 F13B

3.68e-0531042EFO_0021844
DiseaseWeill-Marchesani Syndrome, Autosomal Dominant

ADAMTS10 LTBP2

3.68e-0531042C1869115
DiseaseWeill-Marchesani Syndrome, Autosomal Recessive

ADAMTS10 LTBP2

3.68e-0531042C1869114
DiseaseSchizophrenia

PSD CHD4 CSMD2 ITGB3 JAG2 TYR GJA8 THBS1 CAMKK2 STON2 LRP2 ZNF565

6.64e-0588310412C0036341
Diseasesemaphorin-6A measurement

CFH MRC1

7.35e-0541042EFO_0020721
DiseaseWeill-Marchesani syndrome

ADAMTS10 LTBP2

7.35e-0541042cv:C0265313
DiseaseWeill-Marchesani syndrome (is_implicated_in)

ADAMTS10 LTBP2

7.35e-0541042DOID:0050475 (is_implicated_in)
Diseasecreatinine measurement

CFH CDK12 SPEG OBSCN PHF7 PLXNB2 LACTB JAG2 ADAMTS7 LRP2 SLC14A2 PSD4

2.03e-0499510412EFO_0004518
Diseasesialic acid-binding Ig-like lectin 6 measurement

SIGLEC12 CFH

3.40e-0481042EFO_0008285
Diseasetumor necrosis factor receptor superfamily member 19L measurement

CFH RELT

3.40e-0481042EFO_0008309
DiseaseMalignant neoplasm of breast

FLNA OBSCN DVL3 PHF7 FAM131A CFHR5 PGR JAG2 THBS1 EGFR FASTKD3 ZNF541

4.05e-04107410412C0006142
Diseasesialic acid-binding Ig-like lectin 9 measurement

SIGLEC12 SIGLEC7

4.36e-0491042EFO_0008286
DiseaseC3 glomerulopathy

CFH CFHR5

4.36e-0491042C4087273
Diseaseplexin-B2 measurement

MRC1 PLXNB2

4.36e-0491042EFO_0021867
Diseasecomplement factor H-related protein 5 measurement

CFH CFHR5 F13B

4.42e-04421043EFO_0008098
Diseaseplatelet aggregation

CSMD2 CCDC3 PEAR1

5.42e-04451043GO_0070527
Diseasecortical thickness

LAMC3 XKR6 ADGRA2 JAG2 NHSL1 THBS1 EGFR ADAMTS7 SETD5 BAZ1A PKD1 ADAMTS20

5.55e-04111310412EFO_0004840
Diseasecorneal topography

NHSL1 ADAMTS7 STON2 ADAMTS20

6.10e-041091044EFO_0004345
Diseasemyopathy (implicated_via_orthology)

FLNA MEGF11 PEAR1

6.56e-04481043DOID:423 (implicated_via_orthology)
Diseasehemopexin measurement

CFH CFHR5

6.63e-04111042EFO_0008149
DiseaseSensory hearing loss

GJB2 LRP2

6.63e-04111042C1691779
Diseaselung adenocarcinoma (is_implicated_in)

CHD4 ESCO2 EGFR

6.97e-04491043DOID:3910 (is_implicated_in)
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

FLNA ADAMTS10 PKD1

8.77e-04531043C4707243
Diseaseinterleukin-1 beta measurement

CFH MEGF11 PSD4

9.26e-04541043EFO_0004812
Diseasecomplement factor H-related protein 1 measurement

CFH CFHR5 F13B

1.03e-03561043EFO_0600054
Diseasemembranous glomerulonephritis (biomarker_via_orthology)

CFH LRP2

1.09e-03141042DOID:10976 (biomarker_via_orthology)
Diseasemyeloid cell surface antigen CD33 measurement

SIGLEC12 SIGLEC7

1.25e-03151042EFO_0008238
DiseaseProteinuria

ADAMTS7 LRP2

1.25e-03151042HP_0000093
Diseaseskin pigmentation

CFHR5 TYR MEGF11

1.88e-03691043EFO_0003784
Diseasesystemic lupus erythematosus

CFH CDK12 ADAM15 PHRF1 KCP LAMC2 XKR6 COQ2 ARHGAP27

2.08e-037991049MONDO_0007915
DiseaseEndometrial Carcinoma

CHD4 PGR EGFR

2.13e-03721043C0476089
Diseasecoagulation factor measurement

CFH CFHR5

2.24e-03201042EFO_0004634
DiseaseCOVID-19 (is_implicated_in)

CFH C4BPB

2.47e-03211042DOID:0080600 (is_implicated_in)
Diseasenephrosis (biomarker_via_orthology)

CFH LRP2

2.71e-03221042DOID:2527 (biomarker_via_orthology)
Diseasedilated cardiomyopathy (implicated_via_orthology)

JAG2 EGFR LTBP2

2.87e-03801043DOID:12930 (implicated_via_orthology)
DiseaseSensorineural Hearing Loss (disorder)

GJB2 LRP2

2.97e-03231042C0018784

Protein segments in the cluster

PeptideGeneStartEntry
SEICFPTVPGCPGAW

ESYT1

601

Q9BSJ8
ELISRLCGSPCPAVW

CDK12

946

Q9NYV4
GSPRCPNCSFLPDLW

C9orf50

186

Q5SZB4
LWSSPLPRCVAECGN

CSMD2

1086

Q7Z408
TCLPNLTWSGTPPDC

CSMD2

3171

Q7Z408
ARPPGSCWDPTQCTR

C19orf48

26

Q6RUI8
VRASWRACCPPASPA

ADGRA2

1076

Q96PE1
SGWQCRPTRGDCDLP

ADAM15

476

Q13444
PLVDPWIERPCCGDT

RTL10

41

Q7L3V2
WRPLPSCEEKSCDNP

CFH

256

P08603
AWPCPNTVDCFVSRP

GJB2

171

P29033
RCSPPRCWTPSEPES

AHDC1

631

Q5TGY3
RGRCWAAGPVPELCP

FBN3

321

Q75N90
CWDPSPRGCFTLPRS

DVL3

336

Q92997
ISRICGSPCPAVWPD

CDK13

926

Q14004
LDWSECTPSCGPGLR

ADAMTS10

951

Q9H324
ACVLEPCPPYWAVGD

ADAMTS13

736

Q76LX8
PRPAEIWDCFTPCGE

ADAMTS20

1196

P59510
WPESSRPCGTEDCEP

ADAMTS7

1616

Q9UKP4
WTPESPSPACQCSRP

ABCA7

1336

Q8IZY2
PEGDWFCPECRPKQR

BAZ1A

1186

Q9NRL2
WALLGVAGSCPEPCA

ISLR2

11

Q6UXK2
CPEWREECSFELPPG

RAB11FIP5

66

Q9BXF6
PPEWVPDEACGFCTA

ZFYVE28

811

Q9HCC9
PSGLWEALTPCNGCR

ANKS1B

401

Q7Z6G8
LPCTWSIGLAAEPGC

COQ2

91

Q96H96
TPGWLGDTCELPCPD

MEGF11

511

A6BM72
LPCLCLEGWSATPDA

IL17REL

176

Q6ZVW7
WGECGAEEPPSTPCL

JAG2

946

Q9Y219
WAPPCSPGSAKCPRE

KIF12

546

Q96FN5
IPLTWRCDGHPDCPD

CD320

146

Q9NPF0
WSPQTPAPPCSRCFA

LACTB

91

P83111
EALIPFCSPPDWCLS

NHSL1

981

Q5SYE7
QGKWSSPPVCLEPCT

F13B

441

P05160
GQPCSCWPRPDSVVL

PLXNB2

1501

O15031
LSCGADWVFIPECPP

PFKM

221

P08237
DPACCSPIVPRNEWK

PGLYRP1

26

O75594
PSEPCERPWEGPHTC

PEAR1

51

Q5VY43
RPGASWAFLSCPPED

MEGF8

2166

Q7Z7M0
PVDEWFCPECAAPGV

PHRF1

221

Q9P1Y6
CWERVGCPPGHREEP

TUBGCP6

296

Q96RT7
DEKDCPTQPFRCPSW

LRP2

1301

P98164
CPWLTEEGPACSRPA

OBSCN

7921

Q5VST9
WVPAGDAACGCPRLL

NTN3

506

O00634
PPACEVTSSWCLFGP

PGR

131

P06401
SPEGCWGPEPRDCVS

EGFR

511

P00533
WEPELPSCSRVCQPP

CR1

286

P17927
WEPELPSCSRVCQPP

CR1

736

P17927
WEPELPSCSRVCQPP

CR1

1186

P17927
ACQLPSEWRPLSEGC

CCDC3

21

Q9BQI4
WSGSPASDCDPLCPE

DBF4B

356

Q8NFT6
WRSEELCPLSCPPHS

FCGBP

1126

Q9Y6R7
LVDSCAPGLCPDWDS

FLNA

201

P21333
WPCPNVVDCFVSRPT

GJA8

186

P48165
PAGSEPWLCQPAPRC

IGFL2

26

Q6UWQ7
KDCQPLCPPLTGSWE

FAM131A

326

Q6UXB0
TWAPPFPICKSRDCD

C4BPB

126

P20851
QWSEPPRCLDPCVVS

CFHR5

496

Q9BXR6
GAFWGVTLCAPCPPR

LTBP2

581

Q14767
TECPRAWQCSDVPEP

ESCO2

516

Q56NI9
WCSDEALPLGSPRCD

ITGB3

51

P05106
VRGSPCVESCWAPAP

CAMKK2

556

Q96RR4
CVESCWAPAPGSPAR

CAMKK2

561

Q96RR4
WEILPAMPTPRCACS

KLHDC8A

306

Q8IYD2
VSGAPAPWVEQCICP

LAMC2

371

Q13753
CSLCPFSPTDPGWPA

FLAD1

496

Q8NFF5
PRCAWSPSLCSPRAG

HES7

171

Q9BYE0
PEIPNGEWLCPRCTC

CHD4

481

Q14839
PGWSRCPPSLLCALS

INAVA

66

Q3KP66
CSLPAEAALCWRAPG

IL17RC

391

Q8NAC3
WRCRCPGLSGEDTIP

LRRN4

566

Q8WUT4
SWVLCDRCTPIPGGP

PKD1

1581

P98161
TPEPKCPEDWGASSR

MRC1

641

P22897
LPEASDDFCPGIRCW

TPSG1

146

Q9NRR2
PRSPWGDCAEPSCLC

TMEM105

61

Q8N8V8
EGDCAISPPRCPRRW

PSD

11

A5PKW4
DISGQVTCPPDWPCG

SSPOP

1831

A2VEC9
LIANCSSWPCAEGEP

SSPOP

3171

A2VEC9
WSPCSRSCTDPARPA

SSPOP

3891

A2VEC9
SEWSPCGPCLPPSAL

SSPOP

4531

A2VEC9
RLCPDPGACPDSCQW

SSPOP

4606

A2VEC9
KPSSGPVCWLCLREP

PHF7

26

Q9BWX1
PTWRGPTLCVVGCPL

KCP

1471

Q6ZWJ8
SWPGCCSEAELEKPR

OVCH1

841

Q7RTY7
LCPWLCSRQPEPFGV

FASTKD3

41

Q14CZ7
CPRGRSSVWGPPDAC

MIIP

66

Q5JXC2
ESLPCTLAPCPWRSP

PSD4

426

Q8NDX1
CSVAGSWVCPRPLAR

ARHGAP27

181

Q6ZUM4
SPNSEGETVPTWCPC

SETD5

81

Q9C0A6
LTCSVPWACEQGTPP

SIGLEC7

166

Q9Y286
WEAFGPPGSCRFPRC

PPP1R26

16

Q5T8A7
ITPEACTGPSPCAVW

SLC25A48

206

Q6ZT89
EPALESPTCCLLWRP

KDF1

66

Q8NAX2
LCQPDGTWSSPLPEC

SVEP1

2421

Q4LDE5
GTWSSPLPECVPVEC

SVEP1

2426

Q4LDE5
LTCSVPWACEQGTPP

SIGLEC12

291

Q96PQ1
PCWTCPSFDSLGRCP

STON2

131

Q8WXE9
VRLLCPVPSEECPTW

ADGRD2

321

Q7Z7M1
TLPPLCCCGPDFWDA

CCDC15

881

Q0P6D6
PLPELLFPWTCRGCG

ZNF513

306

Q8N8E2
SCCAELLWGIPLPPD

XKR6

511

Q5GH73
ATVPDGECCPRCWPS

THBS1

361

P07996
VTGPWCPDLESRCEK

ZNF565

111

Q8N9K5
VADPDCRWCPAPDCG

RNF19A

211

Q9NV58
PAPEPSCLWLRRCGA

SPEG

86

Q15772
GPSPSLRDACSLPWD

SHC2

371

P98077
VGRAPGWAPTCCLPV

WDR97

191

A6NE52
GWAPTCCLPVPDLRL

WDR97

196

A6NE52
CPPWSGDRSPCGQLS

TYR

36

P14679
PLNCSSWLGCPEEGA

SCART1

771

Q4G0T1
EVVFPWPPLCCRRTG

UPK1A

181

O00322
WPPDSCCVREFPGCS

TSPAN12

176

O95859
TLCRPCPPGTFSAAW

RELT

46

Q969Z4
WGSCTPEEPEESLRP

ZNF212

341

Q9UDV6
PDTWLASRVPCPTCR

TMEM129

336

A0AVI4
GLPPCTWPFCLSALT

SLC14A2

856

Q15849
MGSRPCSPSACLAPW

PRR23C

1

Q6ZRP0
SCASWLCPLPLAPGR

ZNF683

56

Q8IZ20
AECWPEGGSVPACLP

ZNF541

381

Q9H0D2
PGLSPPASWVEICSC

LAMC3

661

Q9Y6N6