Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionN6-methyladenosine-containing RNA reader activity

YTHDF1 YTHDF2 YTHDF3

7.64e-05151133GO:1990247
GeneOntologyBiologicalProcesscerebellar Purkinje cell layer development

CACNA1A LHX1 TTC21B HSPA5 AGTPBP1

1.87e-06391095GO:0021680
GeneOntologyBiologicalProcesscerebellar Purkinje cell differentiation

CACNA1A LHX1 TTC21B AGTPBP1

2.13e-06181094GO:0021702
GeneOntologyBiologicalProcesscerebellar Purkinje cell layer formation

CACNA1A LHX1 TTC21B AGTPBP1

3.35e-06201094GO:0021694
GeneOntologyBiologicalProcesscerebellar Purkinje cell layer morphogenesis

CACNA1A LHX1 TTC21B AGTPBP1

8.57e-06251094GO:0021692
GeneOntologyBiologicalProcesscerebellum morphogenesis

CACNA1A LHX1 TTC21B HSPA5 AGTPBP1

1.63e-05601095GO:0021587
GeneOntologyBiologicalProcesshindbrain morphogenesis

CACNA1A LHX1 TTC21B HSPA5 AGTPBP1

2.24e-05641095GO:0021575
GeneOntologyBiologicalProcesscell differentiation in hindbrain

CACNA1A LHX1 TTC21B AGTPBP1

2.37e-05321094GO:0021533
GeneOntologyBiologicalProcesscerebellar cortex formation

CACNA1A LHX1 TTC21B AGTPBP1

3.03e-05341094GO:0021697
GeneOntologyBiologicalProcesscerebellar cortex development

CACNA1A LHX1 TTC21B HSPA5 AGTPBP1

3.71e-05711095GO:0021695
GeneOntologyBiologicalProcesscerebellar cortex morphogenesis

CACNA1A LHX1 TTC21B AGTPBP1

1.20e-04481094GO:0021696
GeneOntologyCellularComponentcytoplasmic ribonucleoprotein granule

CKAP5 LARP1B YTHDF1 AGO1 UPF2 ANKRD34C YTHDF2 YTHDF3

9.54e-052691118GO:0036464
GeneOntologyCellularComponentribonucleoprotein granule

CKAP5 LARP1B YTHDF1 AGO1 UPF2 ANKRD34C YTHDF2 YTHDF3

1.49e-042871118GO:0035770
DomainYTH_domain

YTHDF1 YTHDF2 YTHDF3

2.03e-0651113IPR007275
DomainYTH

YTHDF1 YTHDF2 YTHDF3

2.03e-0651113PS50882
DomainYTH

YTHDF1 YTHDF2 YTHDF3

2.03e-0651113PF04146
DomainPecanex_C

PCNX3 PCNX1

2.08e-0441112PF05041
DomainPecanex

PCNX3 PCNX1

2.08e-0441112IPR007735
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CACNA1A SESTD1 ZNRD2 SIPA1L3 CKAP5 SIRPA SHANK3 AGO1 ZKSCAN1 EHMT2 OSBPL3 NAV1 WDFY3 PCM1 TP53BP1 TBL1X TPD52L2

1.51e-089631131728671696
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

POP4 LAD1 INSRR ELP6 NSRP1 PTPRB EHMT2 PLEC ACAP2 TP53BP1 DYNC1LI2

2.85e-083601131133111431
Pubmed

YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA.

YTHDF1 YTHDF2 YTHDF3

3.34e-083113328106072
Pubmed

YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation.

YTHDF1 YTHDF2 YTHDF3

3.34e-083113335508130
Pubmed

A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA.

YTHDF1 YTHDF2 YTHDF3

3.34e-083113332492408
Pubmed

m6A enhances the phase separation potential of mRNA.

YTHDF1 YTHDF2 YTHDF3

3.34e-083113331292544
Pubmed

Comprehensive Analysis of YTH Domain Family in Lung Adenocarcinoma: Expression Profile, Association with Prognostic Value, and Immune Infiltration.

YTHDF1 YTHDF2 YTHDF3

3.34e-083113334497675
Pubmed

m6A-binding YTHDF proteins promote stress granule formation.

YTHDF1 YTHDF2 YTHDF3

3.34e-083113332451507
Pubmed

N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.

YTHDF1 YTHDF2 YTHDF3

3.34e-083113327371828
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

SIPA1L3 GTSE1 CKAP5 MAML1 ELP6 CEP350 PLEKHG1 PJA2 AGO1 OSBPL3 PLEC YTHDF2 PCM1 DYNC1LI2 TPD52L2

1.20e-078531131528718761
Pubmed

N6-methyladenosine-dependent regulation of messenger RNA stability.

YTHDF1 YTHDF2 YTHDF3

1.33e-074113324284625
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

MYO9A SIPA1L3 GTSE1 CKAP5 LARP1B CEP350 PLEKHG1 PJA2 FAM13A OSBPL3 TET1 NAV1 PLEC YTHDF2 PCM1

1.36e-078611131536931259
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

FOXM1 UBR1 CDK12 GTSE1 CKAP5 ADCY6 PALB2 FAM13A PLEC PHF10 PCM1 TP53BP1 AGTPBP1 DYNC1LI2

2.34e-077741131415302935
Pubmed

Context-dependent functional compensation between Ythdf m6A reader proteins.

YTHDF1 YTHDF2 YTHDF3

3.32e-075113332943573
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCNX3 CDK12 SIPA1L3 GTSE1 LAD1 MAML1 ELP6 ICE1 PLEKHG1 KMT2C FZR1 THADA NAV1 PCNX1 WDFY3 PLEC

5.98e-0711051131635748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

APBA2 CHD9 EZH1 ADCY6 NSRP1 PJA2 THADA ARHGEF33 BRDT EHMT2 OSBPL3 TNFSF13B WDFY3 PHF10 PCM1 AGTPBP1

6.81e-0711161131631753913
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

CKAP5 LARP1B CEP350 YTHDF1 AGO1 UPF2 TAGLN2 PLEC PHF10 YTHDF2 YTHDF3 AGTPBP1 TPD52L2

7.05e-077241131336232890
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

CDK12 RADX SYTL2 MAML1 ICE1 CEP350 YTHDF1 NAV1 YTHDF2 YTHDF3 PCM1 AGTPBP1 DYNC1LI2

8.09e-077331131334672954
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

CKAP5 ELP6 ICE1 PALB2 EHMT2 TET1 NAV1 PLEC PCM1 TBL1X

1.17e-064181131034709266
Pubmed

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.

CHD9 ZFPM2 YTHDF1 EHMT2 NAV1 YTHDF2

1.59e-06109113633554859
Pubmed

Interaction network of human early embryonic transcription factors.

MAML1 PCGF5 ZBTB14 KMT2C EHMT2 TET1 PHF10 YTHDF3 TBL1X

2.33e-06351113938297188
Pubmed

Human transcription factor protein interaction networks.

RADX MAML1 PCGF5 ZBTB14 ZFPM2 YTHDF1 LHX1 KMT2C AGO1 ZKSCAN1 EHMT2 PHF10 YTHDF2 YTHDF3 PCM1 TP53BP1 TBL1X

3.74e-0614291131735140242
Pubmed

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

LAD1 INSRR ICE1 OSBPL3 PKP1 PLEC HSPA5 DYNC1LI2

4.37e-06284113829459677
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SIPA1L3 SYTL2 SHANK3 CEP350 GPALPP1 THADA OSBPL3 TTC21B DISP3 TAGLN2

5.05e-064931131015368895
Pubmed

Mettl14-mediated m6A modification ensures the cell-cycle progression of late-born retinal progenitor cells.

FOXM1 YTHDF1 YTHDF2 YTHDF3

5.12e-0635113437269288
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

FOXM1 CKAP5 PALB2 CEP350 GPALPP1 EHMT2 NAV1 TAGLN2 ACAP2 PCM1 TPD52L2

8.62e-066451131125281560
Pubmed

Cytoplasmic m6A reader YTHDF3 promotes mRNA translation.

YTHDF1 YTHDF3

1.05e-052113228106076
Pubmed

Deletion of YTHDF1 (not YTHDF3) reduced brain and gut damage after traumatic brain injury.

YTHDF1 YTHDF3

1.05e-052113239081030
Pubmed

Characterization of cDNA clones containing CCA trinucleotide repeats derived from human brain.

CACNA1A SIRPA

1.05e-05211328525433
Pubmed

Inhibition of YTHDF1 prevents hypoxia-induced pulmonary artery smooth muscle cell proliferation by regulating Foxm1 translation in an m6A-dependent manner.

FOXM1 YTHDF1

1.05e-052113236736607
Pubmed

FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner.

FOXM1 FZR1

1.05e-052113218758239
Pubmed

YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer.

YTHDF1 YTHDF2

1.05e-052113234408926
Pubmed

N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.

YTHDF1 YTHDF2

1.05e-052113226046440
Pubmed

The mechanism underlying redundant functions of the YTHDF proteins.

YTHDF1 YTHDF2

1.05e-052113236694229
Pubmed

YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.

YTHDF2 YTHDF3

1.05e-052113232905781
Pubmed

Novel autosomal recessive LAMA3 and PLEC variants underlie junctional epidermolysis bullosa generalized intermediate and epidermolysis bullosa simplex with muscular dystrophy in two consanguineous families.

LAMA3 PLEC

1.05e-052113229797489
Pubmed

Tottering mouse motor dysfunction is abolished on the Purkinje cell degeneration (pcd) mutant background.

CACNA1A AGTPBP1

1.05e-052113210630211
Pubmed

Novel interactions between FOXM1 and CDC25A regulate the cell cycle.

FOXM1 CDC25A

1.05e-052113223240008
Pubmed

Transgelin-2 and phosphoregulation of the LIC2 subunit of dynein govern mitotic spindle orientation.

TAGLN2 DYNC1LI2

1.05e-052113232467330
Pubmed

FOXM1 promotes invasion and migration of colorectal cancer cells partially dependent on HSPA5 transactivation.

FOXM1 HSPA5

1.05e-052113227034162
Pubmed

Chromosomal localization of the neurological mouse mutations tottering (tg), Purkinje cell degeneration (pcd), and nervous (nr).

CACNA1A AGTPBP1

1.05e-05211328738138
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

CACNA1A XIRP1 SHANK3 YTHDF1 KMT2C AGO1 TSGA10IP

1.17e-05233113737704626
Pubmed

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PLEKHG1 FZR1 KIDINS220 INTS2 NAV1

2.25e-05103113510574462
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

MYO9A SIPA1L3 LAMA3 CHD9 NSRP1 KMT2C THADA KIDINS220 PTPRB FAM13A INTS2 TTC21B NAV1 METTL15 PCM1 TBL1X

2.59e-0514891131628611215
Pubmed

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

CKAP5 YTHDF1 AGO1 YTHDF2 YTHDF3

2.70e-05107113530995489
Pubmed

m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs.

YTHDF1 YTHDF2 YTHDF3

3.12e-0519113336039295
Pubmed

GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway.

FOXM1 GTSE1

3.13e-053113233328578
Pubmed

Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phase.

FOXM1 FZR1

3.13e-053113218573889
Pubmed

YTH: a new domain in nuclear proteins.

YTHDF2 YTHDF3

3.13e-053113212368078
Pubmed

The anaphase-promoting complex/cyclosome co-activator, Cdh1, is a novel target of human papillomavirus 16 E7 oncoprotein in cervical oncogenesis.

FOXM1 FZR1

3.13e-053113235738876
Pubmed

Overexpression of G2 and S phase-expressed-1 contributes to cell proliferation, migration, and invasion via regulating p53/FoxM1/CCNB1 pathway and predicts poor prognosis in bladder cancer.

FOXM1 GTSE1

3.13e-053113230414902
Pubmed

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

YTHDF2 YTHDF3

3.13e-053113222575960
Pubmed

m6A modification controls the innate immune response to infection by targeting type I interferons.

YTHDF2 YTHDF3

3.13e-053113230559377
Pubmed

USP39 facilitates breast cancer cell proliferation through stabilization of FOXM1.

FOXM1 FZR1

3.13e-053113236119839
Pubmed

Usf2 Deficiency Promotes Autophagy to Alleviate Cerebral Ischemia-Reperfusion Injury Through Suppressing YTHDF1-m6A-Mediated Cdc25A Translation.

YTHDF1 CDC25A

3.13e-053113237914905
Pubmed

The m6 A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.

YTHDF1 YTHDF2

3.13e-053113234643063
Pubmed

KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma.

FOXM1 YTHDF1

3.13e-053113239060874
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

CDK12 SIPA1L3 LAD1 LARP1B CEP350 YTHDF1 UPF2 OSBPL3 TAGLN2 PLEC PHF10 YTHDF2 YTHDF3 PCM1 AGTPBP1

3.86e-0513711131536244648
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

CKAP5 LAMA3 CEP350 YTHDF1 PJA2 ZKSCAN1 PKP1 HSPA5 PCM1 TPD52L2

4.65e-056391131023443559
Pubmed

N-Acetylglucosaminyl transferase regulates the expression of the sulfoglucuronyl glycolipids in specific cell types in cerebellum during development.

CACNA1A AGTPBP1

6.25e-05411328910533
Pubmed

Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.

YTHDF1 YTHDF2

6.25e-054113226318451
Pubmed

[Elevated immunoreactive-somatostatin levels in the brain of ataxic mutant mice].

CACNA1A AGTPBP1

6.25e-05411322901364
Pubmed

Identification of Xin-repeat proteins as novel ligands of the SH3 domains of nebulin and nebulette and analysis of their interaction during myofibril formation and remodeling.

XIRP1 NEB

6.25e-054113223985323
Pubmed

FOXM1 Participates in Scleral Remodeling in Myopia by Upregulating APOA1 Expression Through METTL3/YTHDF2.

FOXM1 YTHDF2

6.25e-054113238190128
Pubmed

A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis.

EHMT2 HSPA5

6.25e-054113222430489
Pubmed

TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice.

TET1 OLIG1

6.25e-054113234099715
Pubmed

SUMOylation inhibits FOXM1 activity and delays mitotic transition.

FOXM1 FZR1

6.25e-054113224362530
Pubmed

The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.

YTHDF1 YTHDF2 YTHDF3

6.43e-0524113335179492
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

MYO9A SIPA1L3 LARP1B CEP350 KIDINS220 PCM1

6.49e-05209113636779422
Pubmed

The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.

YTHDF1 YTHDF2 YTHDF3

7.29e-0525113335874829
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SESTD1 SIPA1L3 CKAP5 APBA2 CHD9 SEC31B CEP350 EHMT2 WDFY3 PLEC HSPA5 PCM1 AGTPBP1 NR1D2

7.47e-0512851131435914814
Pubmed

Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice.

CACNA1A LHX1 AGTPBP1

8.22e-0526113335165395
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

CDK12 SIPA1L3 ADCY6 KMT2C PCNX1 WDFY3

9.74e-05225113612168954
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

POP4 ZNRD2 CDK12 RADX CHD9 LARP1B YTHDF1 AGO1 TAGLN2 PHF10 HSPA5 YTHDF2 YTHDF3

9.77e-0511531131329845934
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

SIPA1L3 LAD1 CKAP5 SIRPA KIDINS220 TAGLN2 PLEC HSPA5 TPD52L2

9.89e-05565113925468996
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

MYO9A NEB YTHDF1 AGO1 BRDT PKP1 TAGLN2 PLEC HSPA5 YTHDF2 YTHDF3

9.90e-058441131125963833
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

SESTD1 RADX MAML1 PCGF5 ADCY6 THADA OSBPL3 TTC21B NAV1 PLEC ACAP2 HSPA5 TP53BP1 DYNC1LI2

1.00e-0413211131427173435
Pubmed

Levels of somatostatin and cholecystokinin in the brain of ataxic mutant mice.

CACNA1A AGTPBP1

1.04e-04511328100981
Pubmed

Dual mode of degradation of Cdc25 A phosphatase.

FZR1 CDC25A

1.04e-045113212234927
Pubmed

Sfrp5 is not essential for axis formation in the mouse.

HHEX LHX1

1.04e-045113217133501
Pubmed

Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation.

YTHDF1 YTHDF2

1.04e-045113232610122
Pubmed

Solo/Trio8, a membrane-associated short isoform of Trio, modulates endosome dynamics and neurite elongation.

SESTD1 AGTPBP1

1.04e-045113216943433
Pubmed

A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis.

UPF2 YTHDF2

1.04e-045113230617251
Pubmed

A Cdh1-FoxM1-Apc axis controls muscle development and regeneration.

FOXM1 FZR1

1.04e-045113232152291
Pubmed

rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions.

GTSE1 CKAP5 NAV1 PCM1 DYNC1LI2

1.04e-04142113530217970
Pubmed

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.

LAMA3 CHGB PTPRB TAGLN2 PLEC ANKRD34C HSPA5

1.12e-04333113732665550
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

GTSE1 KMT2C EHMT2 TET1 TBL1X

1.19e-04146113523892456
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

ARHGAP9 PLEC ANKRD34C HSPA5 PCM1 TP53BP1

1.23e-04235113630258100
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

GTSE1 LARP1B PCGF5 KIF24 YTHDF1 EHMT2 HSPA5 YTHDF2 YTHDF3 PCM1

1.29e-047231131034133714
Pubmed

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.

PCNX3 MYO9A SIPA1L3 CKAP5 LAMA3 YTHDF1 KIDINS220 AGO1 TAGLN2 YTHDF2

1.42e-047321131034732716
Pubmed

New gene functions in megakaryopoiesis and platelet formation.

SIRPA ZFPM2 THADA PLEC

1.45e-0481113422139419
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

GTSE1 MAML1 PCGF5 CEP350 GPALPP1 YTHDF1 PJA2 UPF2 YTHDF2 YTHDF3 AGTPBP1 TBL1X

1.46e-0410381131226673895
Pubmed

Junctional Epidermolysis Bullosa

LAMA3 PLEC

1.56e-046113220301304
Pubmed

Initial characterization of the human central proteome.

LAMA3 YTHDF3

1.56e-046113221269460
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CACNA1A GPALPP1 AGO1 PKP1 TAGLN2 PHF10 PCM1 TP53BP1

1.67e-04475113831040226
Pubmed

MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.

HHEX LHX1 KMT2C

1.70e-0433113332439762
Pubmed

Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.

CDK12 SYTL2 HSPA5 TP53BP1

1.75e-0485113416051665
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

ELP6 CEP350 PLEKHG1 UPF2 TTC21B PCM1

1.77e-04251113629778605
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

CDK12 PCGF5 FZR1 CCDC198 AGO1 INTS2 RTL1 CNGB3 PLEC HSPA5 YTHDF2

1.91e-049101131136736316
Pubmed

A human MAP kinase interactome.

MYO9A LAMA3 NEB CEP350 KMT2C NAV1 PLEC HSPA5

1.95e-04486113820936779
InteractionFMR1 interactions

ZNRD2 CKAP5 SHANK3 ZFPM2 YTHDF1 FZR1 AGO1 ZKSCAN1 EHMT2 WDFY3 YTHDF2 YTHDF3 PCM1 TP53BP1 TPD52L2

3.20e-0753611315int:FMR1
InteractionSAMD4B interactions

CEP350 PLEKHG1 AGO1 OSBPL3 NAV1 YTHDF2 YTHDF3

5.69e-061221137int:SAMD4B
InteractionSP110 interactions

UBL3 APBA2 PJA2 OSBPL3 TNFSF13B PCM1 TP53BP1

5.69e-061221137int:SP110
InteractionTOP3B interactions

PCNX3 CDK12 SIPA1L3 GTSE1 LAD1 MAML1 ELP6 ICE1 YTHDF1 PLEKHG1 KMT2C FZR1 THADA UPF2 NAV1 PCNX1 WDFY3 PLEC HSPA5 YTHDF2 YTHDF3 TP53BP1

1.94e-05147011322int:TOP3B
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

EZH1 KMT2C EHMT2

3.32e-0434723487
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LAMA3 SIRPA KIF24 KMT2C UPF2 NAV1 PLEC AGTPBP1 TBL1X

1.20e-09186113923b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXM1 CACNA1A SIPA1L3 THADA DNAJC28 TMEM132D TESC

2.47e-07168113708f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HHEX LAMA3 PLEKHG1 PTPRB BTNL3 NAV1

2.72e-061541136e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCellAdult-Immune-mast_cell-D175|Adult / Lineage, Cell type, age group and donor

CACNA1A ARHGAP9 SEC31B SHANK3 BRDT NAV1

3.28e-0615911369f53fe2e0f25448d62a591c8e528e9a49b5400d5
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO9A SYTL2 NEB GPR83 OSBPL3 TESC

4.98e-0617111368719a18c9e6b6f5d8ec4e937c2bda1e36441c9ec
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-BM_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO9A SYTL2 NEB GPR83 OSBPL3 TESC

4.98e-061711136f4cdd7862c8fe99ee765a2f3ed375b584f4976c5
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO9A CKAP5 CHD9 CEP350 HSPA5 PCM1

5.88e-061761136749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A SIRPA CCDC198 TMEM132D WDFY3 TBL1X

6.90e-061811136071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A SIRPA CCDC198 TMEM132D WDFY3 TBL1X

7.35e-061831136738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 SHANK3 PLEKHG1 PTPRB NAV1 AGTPBP1

8.83e-0618911366463890d8dbee4bc198f91628a5f784970de786a
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

SHANK3 PLEKHG1 PTPRB NAV1 PHF10 HSPA5

9.95e-061931136479abb1cd2eb978b8a4fdb900069a6329fc8cade
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 SHANK3 PLEKHG1 PTPRB NAV1 AGTPBP1

1.06e-0519511366bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCellEntopeduncular-Macroglia-POLYDENDROCYTE|Entopeduncular / BrainAtlas - Mouse McCarroll V32

UBL3 LAD1 KIF24 NAV1 OLIG1

3.56e-051461135a317f14a1aab11ffcce65baeb1c475c04324315f
ToppCellLPS-antiTNF-Endothelial-Endothelial-FOXM1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXM1 GTSE1 CKAP5 KIF24 PTPRB

6.01e-0516311355285318c52aa31c9b22dc2ffff078e32e408604d
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

FOXM1 GTSE1 CHGB KIF24 CDC25A

6.37e-051651135a5c3af634d2698f9a01cf074791756b7669f9fff
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GARIN1A LAD1 LARP1B SHANK3 ADCY6

6.37e-051651135c39f0479955c4e23921f7a450d3bc251a002200f
ToppCellPosterior_cortex-Macroglia-POLYDENDROCYTE|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

POP4 LAD1 LHX1 NAV1 OLIG1

6.55e-051661135a7ac5a414e3e2ff01f1c452c0a85048b17cba0b6
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 SHANK3 PLEKHG1 PTPRB AGTPBP1

6.55e-0516611358e2faca6a2e76a625de04d6098aa6f98911945c6
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A INSRR CHGB NEB HSPA5

6.74e-051671135b94e8ee8c3fcebedd8fcd719eadddc04c7513c50
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

FOXM1 SYTL2 CEP350 THADA TNFSF13B

7.13e-051691135b66ffc2b2b6bfcc3a6e639d9d31d3de95f4a94e1
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A HHEX CHGB NEB TMEM132D

7.54e-051711135fa5cc720bd0045d0307439be547b41d56def5b43
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SHANK3 PLEKHG1 PTPRB PKP1 NAV1

7.96e-051731135f193c63cc536d891c9d23043765e320252bb6e65
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_28|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ELP6 SHANK3 PTPRB TTC21B SERPINF2

7.96e-05173113566488d01e03264fb193285470901c9c4182fbae8
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PALB2 ZNF800 THADA DTWD1 PHF10

8.63e-0517611356b4afd2c9268172063fe5832896bea15e862579e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A CCDC198 TMEM132D WDFY3 TBL1X

8.63e-051761135327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDK12 GBP2 ZNF800 PTPRB PCM1

9.10e-05178113501dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellCOVID-19-kidney-Stressed_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK3 PLEKHG1 PTPRB PHF10 HSPA5

9.35e-051791135754f69bac7a1d5137f5141f6193285ccbfe361cb
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FOXM1 GTSE1 LAMA3 KIF24 CDC25A

9.35e-05179113588d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1A INSRR ELP6 CHGB ZBTB14

1.01e-0418211351923932a9c60e9ec33db69ded441210d1fb07bec
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1A INSRR ELP6 CHGB ZBTB14

1.01e-04182113569ff652f74cc47fbe0bd665ab17c445c5b959dad
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

CDK12 GBP2 CHD9 CEP350 KMT2C

1.04e-0418311358f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A CCDC198 TMEM132D WDFY3 TBL1X

1.04e-04183113592fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-T-T_CD8-CD8_TRM|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SYTL2 APBA2 SEC31B PALB2 BRDT

1.06e-04184113517ffa0e890960c00a3b5fa33d48caba66c61dbb0
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK3 PLEKHG1 PTPRB PHF10 HSPA5

1.09e-041851135673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FOXM1 GTSE1 CKAP5 LAMA3 KIF24

1.09e-04185113530e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCell10x5'-Liver-Lymphocytic_NK-Cycling_NK|Liver / Manually curated celltypes from each tissue

FOXM1 XIRP1 GTSE1 KIF24 CDC25A

1.18e-0418811355eb94e652a734c6f15c68a178e9d05f0febcf34c
ToppCellfacs-Heart-LV-3m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRPPA DNAJC28 TET1 TESC AGTPBP1

1.18e-04188113540ce7125fca6f6b6b5cc1637c87d43c29b08f4f1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SHANK3 PLEKHG1 PTPRB NAV1 AGTPBP1

1.18e-041881135c2c51c6526defe2600302901159b8abbb58d7595
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A SIPA1L3 CCDC198 TMEM132D TBL1X

1.18e-04188113563a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellfacs-Heart-LV-3m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRPPA DNAJC28 TET1 TESC AGTPBP1

1.18e-041881135ba7f7ce034c0f42742bf2461f68f8d343ee593a5
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A CCDC198 TMEM132D WDFY3 TBL1X

1.21e-041891135904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellsevere_COVID-19-Plasmablast|severe_COVID-19 / disease group, cell group and cell class (v2)

FOXM1 GTSE1 KIF24 ENAM CDC25A

1.21e-041891135953143b2c2e87a4d8ef033a5fbb155fe62e9c78e
ToppCellControl-Endothelial-Endothelial-FOXM1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXM1 GTSE1 CKAP5 KIF24 CDC25A

1.21e-0418911351e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FOXM1 GTSE1 PLEKHG1 PTPRB NAV1

1.24e-04190113531de1727822e9818652946dfb962daee77ffad68
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHD9 LARP1B CEP350 ZKSCAN1 TBL1X

1.27e-04191113560c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

UBR1 KIDINS220 OSBPL3 HSPA5 AGTPBP1

1.27e-0419111359454f642c3621370fa23640b631301346b300950
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYTL2 ADCY6 KIDINS220 CCDC198 TESC

1.27e-041911135297bc79adc5fef211497819b4861b52cd26ac754
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

MYO9A CHGB LHX1 GPR83 PJA2

1.27e-0419111355d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCellEntopeduncular-Neuronal-Inhibitory|Entopeduncular / BrainAtlas - Mouse McCarroll V32

MYO9A CHGB LHX1 GPR83 PJA2

1.27e-04191113573dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYTL2 ADCY6 KIDINS220 CCDC198 TESC

1.27e-041911135e1ec165ba6578cefd88895e7e183190e79f733a4
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHD9 LARP1B CEP350 ZKSCAN1 TBL1X

1.27e-04191113509db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHD9 LARP1B CEP350 ZKSCAN1 TBL1X

1.27e-041911135973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FOXM1 GTSE1 CKAP5 KIF24 FZR1

1.30e-04192113527723f4e320e49d4a3daafa2d8d3946ff79fab64
ToppCell5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HHEX SHANK3 PLEKHG1 PTPRB TAGLN2

1.30e-0419211355a0615fdc217554ccd611504b16e5d97628e207d
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FOXM1 GTSE1 CKAP5 KIF24 FZR1

1.30e-041921135026f3e38970bea1e6e8d76a4e2becdfb8484b2ff
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 SHANK3 PLEKHG1 PTPRB AGTPBP1

1.30e-0419211353259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 SHANK3 PLEKHG1 PTPRB NAV1

1.30e-04192113556b021c297a21dff357531f21e2464f85186106d
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHD9 CEP350 ACAP2 HSPA5 YTHDF2

1.33e-04193113506b65110db974f4ef90d3511ff34428976a52c9c
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHD9 CEP350 ACAP2 HSPA5 YTHDF2

1.33e-0419311359c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INSRR SIRPA CHGB NEB HSPA5

1.33e-041931135471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCellfacs-Brain_Myeloid-Hippocampus-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHD9 CEP350 ACAP2 HSPA5 YTHDF2

1.33e-041931135a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INSRR SIRPA CHGB NEB HSPA5

1.33e-041931135fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHD9 CEP350 ACAP2 HSPA5 YTHDF2

1.33e-041931135b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCellLPS_only-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHANK3 ZFPM2 PLEKHG1 PTPRB NAV1

1.36e-04194113558f069efdefa0366033764446b9d6ffd4a17807e
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHANK3 ZFPM2 PLEKHG1 PTPRB NAV1

1.36e-041941135bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCell5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HHEX SHANK3 PLEKHG1 PTPRB TAGLN2

1.40e-041951135f65053811074a7f2ff0368f3a63b88e2a08da1a0
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 SHANK3 PLEKHG1 PTPRB AGTPBP1

1.40e-041951135d35102f95bb1e419d2df05ff0a01b6c5c923acef
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HHEX SHANK3 PLEKHG1 PTPRB TAGLN2

1.46e-04197113598e34e8612f111bb667a574de1faaa785d318ca4
ToppCellPCW_10-12-Endothelial-Endothelial_cycling-endo_proliferating2_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FOXM1 HHEX GTSE1 SHANK3 PTPRB

1.46e-041971135491e12a5fca06b86443c0173f5fa750ea3b8a715
ToppCellPCW_13-14-Endothelial-Endothelial_cycling-endo_proliferating2_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FOXM1 HHEX GTSE1 SHANK3 PTPRB

1.46e-0419711358e655db7c6f04d49927a1f0a75178e5955b4af08
ToppCell5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HHEX SHANK3 PLEKHG1 PTPRB TAGLN2

1.46e-041971135f4834378d5d31560b4efe5dee0d5b5d11caeb10f
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HHEX SHANK3 PLEKHG1 PTPRB TAGLN2

1.50e-041981135ff8a9adc1302a4679ccdfe9ef95ef53e4c7a5391
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HHEX SHANK3 PLEKHG1 PTPRB TAGLN2

1.50e-04198113509e452742aed9f48bf1ffc35c6b06a296bcfe076
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FOXM1 HHEX GTSE1 SHANK3 PTPRB

1.50e-041981135604fb20ca1aaf8f07067a8e1593a30ba335891f7
ToppCellParenchymal-NucSeq-Endothelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SHANK3 ZFPM2 PLEKHG1 PTPRB NAV1

1.53e-041991135a4a9a1c2a34b5a8318a55d1211d6c8661ca9793e
ToppCelldistal-1-Epithelial-Proliferating_Basal|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FOXM1 GTSE1 NEB PKP1 CDC25A

1.53e-04199113593450257180d918c310bca7b5defc74390c48091
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_activated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A LAD1 SIRPA NEB PALB2

1.53e-0419911353b2bd3caf4d189a1726a737b0121860b265eec04
ToppCellLPS_anti-TNF-Endothelial-Endothelial-FOXM1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FOXM1 GTSE1 CKAP5 KIF24 CDC25A

1.53e-04199113598575fcce726589e93fbb4df1aab03e57cb56076
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SESTD1 SHANK3 ZFPM2 PLEKHG1 TAGLN2

1.57e-042001135032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCelldistal-Epithelial-Proliferating_Basal|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FOXM1 GTSE1 NEB PKP1 CDC25A

1.57e-04200113525cc494ef831511840d8c02ec1bd086635cc7edd
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SESTD1 SHANK3 ZFPM2 PLEKHG1 TAGLN2

1.57e-04200113568fce28690246895fd33354b30960ebcc31aa4cc
ToppCellmLN-Dendritic_cell-cDC2|Dendritic_cell / Region, Cell class and subclass

NSRP1 TTC21B METTL15 DYNC1LI2 NR1D2

1.57e-042001135e3f7852aaa26a9b3e626d85e40afde799e873045
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HHEX SHANK3 PTPRB TAGLN2 PLEC

1.57e-04200113593e13937ec74418a697c37d56f57509fb2154780
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SESTD1 SHANK3 ZFPM2 PLEKHG1 TAGLN2

1.57e-042001135376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal-Mesoderm|3m / Sample Type, Dataset, Time_group, and Cell type.

XIRP1 LAD1 NEB KIF24 TNFSF13B

1.57e-042001135538ae964db58c4acafe93f735b3e03fc08fdaac6
ToppCelldistal-Epithelial-Proliferating_Basal-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FOXM1 GTSE1 NEB PKP1 CDC25A

1.57e-042001135cc31e8c28d01e6757c5dd7f485db6acf7409a47e
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SESTD1 SHANK3 ZFPM2 PLEKHG1 TAGLN2

1.57e-0420011357fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCellsevere-CD163+_Monocytes_(Sample_ID1_d7)|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SIRPA TNFSF13B TESC WDFY3 AGTPBP1

1.57e-042001135a3f22826f3d8f917ff0594bdadd93b60763bcaa2
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SESTD1 SHANK3 ZFPM2 PLEKHG1 TAGLN2

1.57e-042001135878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SESTD1 SHANK3 ZFPM2 PLEKHG1 TAGLN2

1.57e-0420011357136936d05ab344a560cf159684c881063b5430d
DrugMuramic acid, N-acetyl [10597-89-4]; Down 200; 13.6uM; MCF7; HT_HG-U133A

SIPA1L3 GBP2 NEB LHX1 DNAJC28 TESC PLEC PCM1

4.43e-0618911283262_DN
DrugMelatonin [73-31-4]; Down 200; 17.2uM; MCF7; HT_HG-U133A

MAML1 LAMA3 NEB ZNF783 LHX1 CNGB3 TESC PLEC

6.23e-0619811285393_DN
Diseasedisease of metabolism (implicated_via_orthology)

YTHDF1 YTHDF2 YTHDF3

6.74e-05211123DOID:0014667 (implicated_via_orthology)
Diseasemean platelet volume

HHEX PCNX3 CDK12 CHD9 SIRPA SHANK3 ZFPM2 FAM13A ZPR1 TESC TAGLN2 PLEC ACAP2

1.34e-04102011213EFO_0004584
DiseaseAmelogenesis imperfecta local hypoplastic form

LAMA3 ENAM

2.96e-0471122C0399367
Diseasetestosterone measurement

FOXM1 UBR1 HHEX ARHGAP9 ADCY6 ZFPM2 GPR83 ZNF800 THADA SERPINF2 SLC24A1 METTL15 NR1D2 TBL1X

3.40e-04127511214EFO_0004908
Diseaseimmature platelet count

SIRPA ZFPM2 TAGLN2 PLEC

7.25e-041061124EFO_0803544
Diseasetriacylglycerol 56:2 measurement

ZPR1 SLC5A12

7.68e-04111122EFO_0010429
DiseaseIschemic stroke, fibrinogen measurement

CHD9 SHANK3 PLEC

1.21e-03551123EFO_0004623, HP_0002140
Diseasecholesterol to total lipids in large HDL percentage

FAM13A ZPR1 TP53BP1

1.21e-03551123EFO_0022234
Diseaserevision of total hip arthroplasty

CRPPA ICE1

1.26e-03141122EFO_0020973
Diseasecholesteryl esters to total lipids in large HDL percentage

FAM13A ZPR1 TP53BP1

1.48e-03591123EFO_0022248
Diseasecholesterol in chylomicrons and extremely large VLDL measurement

EHMT2 ZPR1 TP53BP1

1.56e-03601123EFO_0021898
Diseasecardiovascular disease

ZFPM2 PLEKHG1 THADA ZPR1 NAV1 PCNX1 CDC25A

1.83e-034571127EFO_0000319
Diseaseinterstitial lung disease

FAM13A ZKSCAN1 NAV1

2.14e-03671123EFO_0004244
Diseasevenous thromboembolism, fibrinogen measurement

CHD9 SHANK3 ZFPM2

2.14e-03671123EFO_0004286, EFO_0004623
Diseasetriglycerides in very small VLDL measurement

EHMT2 ZPR1 TP53BP1

2.23e-03681123EFO_0022144
Diseaseuric acid measurement

SESTD1 PCNX3 MYO9A SIPA1L3 SYTL2 INSRR NAV1 TSGA10IP

2.31e-036101128EFO_0004761
Diseaseautism spectrum disorder (implicated_via_orthology)

CHD9 SHANK3 PKP1 WDFY3

2.73e-031521124DOID:0060041 (implicated_via_orthology)
Diseasevenous thromboembolism, plasminogen activator inhibitor 1 measurement

CKAP5 ZFPM2

2.86e-03211122EFO_0004286, EFO_0004792
Diseasebehavioural disinhibition measurement

CRPPA ZFPM2 TMEM132D

2.95e-03751123EFO_0006946
Diseasetriacylglycerol 48:2 measurement

ZPR1 ANKRD34C

3.14e-03221122EFO_0010405
Diseasetriacylglycerol 48:3 measurement

ZPR1 ANKRD34C

3.14e-03221122EFO_0010406
DiseaseLiver carcinoma

FOXM1 GTSE1 KMT2C PKP1 TAGLN2 HSPA5 YTHDF2

3.26e-035071127C2239176
Diseasemonounsaturated fatty acids; 16:1, 18:1 measurement

SEC31B ZPR1 TP53BP1

3.29e-03781123EFO_0022187
Diseasehemoglobin A1 measurement

HHEX FAM234A PLEKHG1 FZR1 THADA YTHDF2 TBL1X

3.75e-035201127EFO_0007629

Protein segments in the cluster

PeptideGeneStartEntry
EQALNQNPKDGTLAS

TTC21B

746

Q7Z4L5
DPQENRNNNTNKSRA

CACNA1A

826

O00555
NEERKSQENLGNPSK

FAM234A

16

Q9H0X4
SQENLGNPSKNEDNV

FAM234A

21

Q9H0X4
DVDRGKNNVTLSPNN

BTNL3

361

Q6UXE8
KGGQRNITDDSRDQP

CDY1

251

Q9Y6F8
NQSEDPRNQRLSKNG

DISP3

216

Q9P2K9
QEPAGSLEENNSDKN

CDK12

1221

Q9NYV4
LLDNRADPNIQDKSG

ANKRD34C

71

P0C6C1
EQQDSPGNKDFLQSL

SERPINF2

446

P08697
ELKASQENQRDLGNG

BRDT

856

Q58F21
DSSKDNRGTQDALNP

ADCY6

606

O43306
QSNGRDPQALAKAVQ

AGO1

831

Q9UL18
QTSFSDQNPRQDQKG

ARHGEF33

801

A8MVX0
LDNLDPNFQSDQQSK

EHMT2

671

Q96KQ7
RKQQRSDLNGPVDNN

APBA2

326

Q99767
NNLLNTTPDRAEQGK

ELP6

6

Q0PNE2
ASNNPEKLNRFQQDS

ACAP2

761

Q15057
DIKDNDRTLQQQPGD

AGTPBP1

501

Q9UPW5
RQQNDQNRPSEKGEK

NSRP1

396

Q9H0G5
PQDDQKLQESLRQGA

CRPPA

416

A4D126
NPERTNGTLNSAQED

KIAA1107

636

Q9UPP5
RNGKRHQDDEPVNSQ

RADX

596

Q6NSI4
VKRNLDSATSPQNGD

MAML1

111

Q92585
FPDKVANLEANNNGR

PTPRB

376

P23467
NKPQENGQDDTSKAD

PCGF5

101

Q86SE9
NPNVNLTDKDGNTAL

KIDINS220

226

Q9ULH0
RTQESGDQDPQEAQK

LAD1

481

O00515
QPSNKKDIDDNSNGT

KMT2C

166

Q8NEZ4
DGRNSNTLLNLDPEN

LAMA3

2521

Q16787
KEEESLNQGARAQPQ

SLC24A1

691

O60721
LNQGARAQPQAKAES

SLC24A1

696

O60721
DQRQDLPSEQNKGAS

HHEX

216

Q03014
QSRNAENESPKGQAS

ZFPM2

1006

Q8WW38
QKELRNQGSTQGDPE

KCNH5

716

Q8NCM2
DPNIKNNAASEGVLA

DYNC1LI2

416

O43237
PAEEDTKQNSNNTRG

PCM1

701

Q15154
NVPLEREATSKNDQN

PCM1

1851

Q15154
LDRNPGSDDNNLNSI

PCNX1

1541

Q96RV3
VTQLDRNPGADDNNL

PCNX3

1326

Q9H6A9
EEKANGVNPDSLLRN

INTS2

951

Q9H0H0
TDRNPNNLDQGEGEK

DNAJC28

351

Q9NX36
RQLNFDSPADNKDRN

KIF24

96

Q5T7B8
AGSNENDDQNLGAKR

LHX1

166

P48742
RIKANSSPGNNSVDD

GBP2

151

P32456
ATQRQDPAAAQEGQD

GAGE2A

46

Q6NT46
QDQDVQDNPRGRSAK

METTL15

386

A6NJ78
GGSARPDAKEEQQQQ

OLIG1

91

Q8TAK6
PSLSDTKQQRNQDAG

FAM13A

536

O94988
TEKNDGQRAPLANNL

GPR83

386

Q9NYM4
SSRNQAAQAAKPEDP

GTSE1

96

Q9NYZ3
KSPSDTLDGRNENLQ

PALB2

356

Q86YC2
DNEDNSNDGTQPSKR

PHF10

31

Q8WUB8
PSQNRKAKDATSDNG

FZR1

71

Q9UM11
EEKPQRAQNISSNAN

CKAP5

1436

Q14008
NPNKLDVNSLTGEER

CHD9

2546

Q3L8U1
GQKQRQPQATDLDSS

ICE1

981

Q9Y2F5
EDDSGPTARKQRKNQ

GPALPP1

66

Q8IXQ4
SSLPDNKQEENTALN

CEP350

506

Q5VT06
SFDPDVAKQEARQQN

A3GALT2

86

U3KPV4
QNKAEINPRTNGDRA

INSRR

466

P14616
EPKRSPAQQESNQAE

FOXM1

31

Q08050
GQRNSSEKRESQNPF

ENAM

931

Q9NRM1
IGDAAKNQLTSNPEN

HSPA5

76

P11021
DEILNRGPGNSKNTE

CCDC198

211

Q9NVL8
PGETQNAFLNERKQA

CHGB

191

P05060
QNNVRGKNDDPDKPS

DTWD1

161

Q8N5C7
ENRETKLNGPGENVS

LARP1B

46

Q659C4
QEGKDLFTQRQNSAP

CDC25A

166

P30304
NLSNDLDNERQTLGP

OSBPL3

486

Q9H4L5
SKNQNAPDSRPEENF

UPF2

146

Q9HAU5
DRVPIDGFSQNENKN

NR1D2

356

Q14995
SGKPQLTADRNNDTA

GARIN1A

236

Q6NXP2
GQLDSNQRDRNTLPK

NAV1

931

Q8NEY1
QDQDNSTLALPSDQK

PKP1

16

Q13835
LKESGREETPQEQNQ

RTL1

141

A6NKG5
PQIAAEQSKDRENGA

SYTL2

81

Q9HCH5
DLNKDDNQSFPRQRT

SYTL2

246

Q9HCH5
DGVPNQDLQQRSQSS

TSGA10IP

56

Q3SY00
NRSAKDNQPVLESLG

THADA

1471

Q6YHU6
KFGQNDANPNTSDSR

TMEM132D

796

Q14C87
KENPRNFSDNQLQEG

TAGLN2

156

P37802
QKEANDSDVQPSGAQ

POP4

11

O95707
EQERDTGQSPQKGLQ

SIPA1L3

1526

O60292
KNGNELSDFQTNVDP

SIRPA

186

P78324
QPKGNDLNSDRQQAF

SEC31B

511

Q9NQW1
NNGSDKGNQQEKERS

SESTD1

181

Q86VW0
SEQKDQAANEGPEQS

TET1

2081

Q8NFU7
SGDQPTIRKENFNNV

TESC

36

Q96BS2
VKPIGENNENEQSSR

CNGB3

11

Q9NQW8
NPSKNREATVNGEEN

TBL1X

186

O60907
QKRDVSSPDENNGQS

ZBTB14

126

O43829
GLEQDQPARRANKDA

ZPR1

156

O75312
LENNDNKPVTNSRDT

YTHDF3

521

Q7Z739
KDPTQALNEQGDSRN

WDFY3

521

Q8IZQ1
QRSASDINLKGEAQP

SHANK3

371

Q9BYB0
EPNSQGQRNREKTGE

UBL3

96

O95164
NQLEKDQSRENSINP

SPANXN2

66

Q5MJ10
NIDGPNAKSVQREQS

EZH1

276

Q92800
IAKNLPENENNETGL

UBR1

786

Q8IWV7
NNDVLQPQAKGFRSD

ARHGAP9

266

Q9BRR9
PAQDGEVQLSQNDDK

TP53BP1

571

Q12888
NIRNDDIADGNPKLT

PLEC

256

Q15149
DKDNPALNAQAALSQ

ZNRD2

81

O60232
VQTQEQEDNKRGPCS

nan

91

A8MUA0
NLPDVNDKQSQAIND

ZNF800

101

Q2TB10
ELQRDNPATGQQNAD

PLEKHG1

66

Q9ULL1
QGGENRNENEESTSK

ZKSCAN1

266

P17029
GTEQENLENGSARKQ

SLC5A12

566

Q1EHB4
SQNSRNKRAVQGPEE

TNFSF13B

126

Q9Y275
EQNTNDREKNHGSSP

PJA2

296

O43164
GEAAAPAQLQNTEKQ

XIRP1

1006

Q702N8
QDINLNSPNKGLLSD

TPD52L2

6

O43399
ENNENKPVTNSRDTQ

YTHDF2

516

Q9Y5A9
NNDNKPVTNSRDTQE

YTHDF1

496

Q9BYJ9
NIQDDFKNPGRNLSS

ZNF670

51

Q9BS34
EGQAPKQQQDSEARV

ZNF783

246

Q6ZMS7
PNKQQERAQSQSGVD

MYO9A

1231

B2RTY4
ASENPQLRQLKAAGD

NEB

366

P20929