Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of basement membrane assembly involved in embryonic body morphogenesis	PHLDB1 PHLDB2	6.69e-05	5	54	2	GO:1904261
GeneOntologyBiologicalProcess	regulation of basement membrane assembly involved in embryonic body morphogenesis	PHLDB1 PHLDB2	6.69e-05	5	54	2	GO:1904259
GeneOntologyBiologicalProcess	basement membrane assembly involved in embryonic body morphogenesis	PHLDB1 PHLDB2	6.69e-05	5	54	2	GO:2001197
GeneOntologyCellularComponent	cytoplasmic region	PHLDB1 STAU2 SAXO1 NME7 DNAH5 PHLDB2 DNAH1	3.74e-05	360	54	7	GO:0099568
GeneOntologyCellularComponent	protein kinase CK2 complex	CSNK2A1 CSNK2A3	3.92e-05	4	54	2	GO:0005956
GeneOntologyCellularComponent	basal cortex	PHLDB1 PHLDB2	1.36e-04	7	54	2	GO:0045180
GeneOntologyCellularComponent	motile cilium	INTU SLC9C1 SAXO1 NME7 DNAH5 DNAH1	2.99e-04	355	54	6	GO:0031514
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	STAU2 SAXO1 NME7 DNAH5 DNAH1	1.34e-03	317	54	5	GO:0032838
GeneOntologyCellularComponent	axonemal dynein complex	DNAH5 DNAH1	1.89e-03	25	54	2	GO:0005858
GeneOntologyCellularComponent	axoneme	SAXO1 NME7 DNAH5 DNAH1	2.01e-03	207	54	4	GO:0005930
GeneOntologyCellularComponent	ciliary plasm	SAXO1 NME7 DNAH5 DNAH1	2.04e-03	208	54	4	GO:0097014
Domain	PH	PHLDB1 FGD4 CYTH2 ARHGEF18 PHLDB2	5.14e-04	229	54	5	PF00169
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DNAH1	7.30e-04	14	54	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DNAH1	7.30e-04	14	54	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DNAH1	7.30e-04	14	54	2	IPR013602
Domain	DHC_N2	DNAH5 DNAH1	7.30e-04	14	54	2	PF08393
Domain	MT	DNAH5 DNAH1	7.30e-04	14	54	2	PF12777
Domain	AAA_8	DNAH5 DNAH1	7.30e-04	14	54	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH5 DNAH1	7.30e-04	14	54	2	IPR011704
Domain	AAA_5	DNAH5 DNAH1	7.30e-04	14	54	2	PF07728
Domain	DHC_fam	DNAH5 DNAH1	8.41e-04	15	54	2	IPR026983
Domain	Dynein_heavy_dom	DNAH5 DNAH1	8.41e-04	15	54	2	IPR004273
Domain	Dynein_heavy	DNAH5 DNAH1	8.41e-04	15	54	2	PF03028
Domain	PH	PHLDB1 FGD4 CYTH2 ARHGEF18 PHLDB2	1.23e-03	278	54	5	SM00233
Domain	PH_DOMAIN	PHLDB1 FGD4 CYTH2 ARHGEF18 PHLDB2	1.25e-03	279	54	5	PS50003
Domain	PH_domain	PHLDB1 FGD4 CYTH2 ARHGEF18 PHLDB2	1.27e-03	280	54	5	IPR001849
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	RBM27 ARHGEF18 STIL SPEN TRIM37 PHLDB2	5.27e-07	184	56	6	32908313
Pubmed	Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta.	PHLDB1 PHLDB2	2.55e-06	2	56	2	20513769
Pubmed	Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.	CSNK2A1 CSNK2A3	2.55e-06	2	56	2	12860116
Pubmed	The zinc-finger protein ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons.	STAU2 ZFR	2.55e-06	2	56	2	16277607
Pubmed	Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.	CSNK2A1 CSNK2A3	2.55e-06	2	56	2	14646071
Pubmed	Assignment of casein kinase 2 alpha sequences to two different human chromosomes.	CSNK2A1 CSNK2A3	2.55e-06	2	56	2	1577469
Pubmed	Molecular cloning of the human casein kinase II alpha subunit.	CSNK2A1 CSNK2A3	2.55e-06	2	56	2	2752008
Pubmed	Structure and sequence of an intronless gene for human casein kinase II-alpha subunit.	CSNK2A1 CSNK2A3	2.55e-06	2	56	2	8420794
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	KMT2C EP400 UBTF CSNK2A1 ZFR	3.91e-06	146	56	5	23892456
Pubmed	Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.	CSNK2A1 CSNK2A3	7.63e-06	3	56	2	15684395
Pubmed	Crystallization and preliminary characterization of crystals of human protein kinase CK2.	CSNK2A1 CSNK2A3	7.63e-06	3	56	2	11092945
Pubmed	Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.	CSNK2A1 CSNK2A3	7.63e-06	3	56	2	2174700
Pubmed	Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.	CSNK2A1 CSNK2A3	7.63e-06	3	56	2	12102635
Pubmed	Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit.	CSNK2A1 CSNK2A3	7.63e-06	3	56	2	1766873
Pubmed	Structural insights into the recruitment of SMRT by the corepressor SHARP under phosphorylative regulation.	CSNK2A1 SPEN	7.63e-06	3	56	2	24268649
Pubmed	Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF.	UBTF CSNK2A1	7.63e-06	3	56	2	7651819
Pubmed	The synaptic scaffolding protein CNKSR2 interacts with CYTH2 to mediate hippocampal granule cell development.	CYTH2 ARHGAP39	7.63e-06	3	56	2	34800437
Pubmed	Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.	CSNK2A1 CSNK2A3	7.63e-06	3	56	2	20625391
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	SLC9C1 CSNK2A1 STAU2 ZFR DALRD3 PHLDB2 DNAH1	1.46e-05	496	56	7	31343991
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	KMT2C PHLDB1 UBTF CSNK2A1 ZFR ECPAS CSNK2A3	1.48e-05	497	56	7	36774506
Pubmed	Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.	DNAH5 DNAH1	1.52e-05	4	56	2	18492703
Pubmed	Liprin-α1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration.	PHLDB1 PHLDB2	1.52e-05	4	56	2	24982445
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	EP400 RBM27 UBTF CSNK2A1 SGF29 SPEN	1.77e-05	339	56	6	30415952
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KMT2C INTU PHLDB1 FAM111A SEL1L3 ARHGEF18 ARHGAP39 PRKAG2 ECPAS NLK DNAH1	2.15e-05	1489	56	11	28611215
Pubmed	Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex.	PHLDB1 PHLDB2	2.54e-05	5	56	2	23940118
Pubmed	An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels.	CSNK2A1 KCNQ3	2.54e-05	5	56	2	25998125
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	EP400 RBM27 CSNK2A1 ECPAS SGF29 SPEN	4.21e-05	396	56	6	26687479
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	INTU PHLDB1 EP400 SEL1L3 RAP1GAP2 SPEN	4.90e-05	407	56	6	12693553
Pubmed	A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.	CSNK2A1 CSNK2A3	5.32e-05	7	56	2	11239457
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH5 DNAH1	5.32e-05	7	56	2	9256245
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	KMT2C EP400 RBM27 UBTF CSNK2A1 ZFR ECPAS SGF29 SPEN	6.23e-05	1103	56	9	34189442
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	EP400 RBM27 SGF29 SPEN	6.62e-05	134	56	4	25452129
Pubmed	p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.	CSNK2A1 CSNK2A3	7.09e-05	8	56	2	12393879
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH5 DNAH1	2.29e-04	14	56	2	9373155
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	EP400 UBTF STAU2 SPEN	2.80e-04	195	56	4	19454010
Pubmed	The embryonic expression pattern of 40 murine cDNAs homologous to Drosophila mutant genes (Dres): a comparative and topographic approach to predict gene function.	PPEF1 NLK	3.01e-04	16	56	2	9817915
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	KMT2C P4HA2 UBTF UNC5C ARHGEF18 PARPBP TRIM37 RPS6KC1	3.27e-04	1084	56	8	11544199
Pubmed	Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.	PHLDB1 PHLDB2	3.41e-04	17	56	2	11001876
Pubmed	Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation.	CSNK2A1 TRIM37	4.28e-04	19	56	2	38225382
Pubmed	Human transcription factor protein interaction networks.	KMT2C EP400 RBM27 UBTF CSNK2A1 STAU2 ZFR SGF29 SPEN	4.32e-04	1429	56	9	35140242
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	KMT2C UBTF ZFR ECPAS	4.42e-04	220	56	4	35785414
Pubmed	Next-generation sequencing to generate interactome datasets.	P4HA2 EP400 CSNK2A1 USP25 ECPAS NME7 SGF29 NLK	4.76e-04	1147	56	8	21516116
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	FAM111A EP400 STAU2 ARHGEF18 SPEN	5.18e-04	410	56	5	26949251
Pubmed	CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.	P4HA2 TNC UBTF STAU2 ECPAS	5.65e-04	418	56	5	35338135
Pubmed	The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.	CSNK2A1 PRKAG2	5.76e-04	22	56	2	9151826
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	KMT2C EP400 RBM27 FGD4 CSNK2A1 STAU2 ARHGAP39 SGF29 SPEN	6.04e-04	1497	56	9	31527615
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	FGD4 CSNK2A1 ARHGEF18 ZFR ARHGAP39 ECPAS CHN2	6.48e-04	916	56	7	32203420
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	KMT2C CSNK2A1 ZFR SPEN	7.25e-04	251	56	4	31076518
Pubmed	Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.	P4HA2 CSNK2A1 RPS6KC1	7.55e-04	110	56	3	14667819
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	EP400 RBM27 UBTF STAU2 ZFR SPEN HMGB1P1	8.23e-04	954	56	7	36373674
Pubmed	Proteomic profiling of Myc-associated proteins.	EP400 UBTF PHLDB2	8.38e-04	114	56	3	21150319
Pubmed	C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.	CYTH2 SGF29	8.71e-04	27	56	2	29420262
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	EP400 RBM27 CSNK2A1 SGF29	9.24e-04	268	56	4	33640491
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	KMT2C CSNK2A1 SGF29	9.49e-04	119	56	3	23508102
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	EP400 RBM27 ZFR SPEN	1.13e-03	283	56	4	30585729
Pubmed	Primary Ciliary Dyskinesia	DNAH5 DNAH1	1.22e-03	32	56	2	20301301
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	PHLDB1 EP400 UBTF CSNK2A1 ZFR SPEN PHLDB2	1.24e-03	1024	56	7	24711643
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EP400 CSNK2A1 ARHGAP39 ECPAS SPEN PHLDB2	1.50e-03	774	56	6	15302935
Cytoband	3q13.2	SLC9C1 PHLDB2	6.64e-04	31	56	2	3q13.2
Cytoband	12q24.33	EP400 GLT1D1	1.59e-03	48	56	2	12q24.33
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PHLDB1 FGD4 CYTH2 ARHGEF18 PHLDB2	3.89e-05	206	34	5	682
GeneFamily	Dyneins, axonemal	DNAH5 DNAH1	4.59e-04	17	34	2	536
GeneFamily	Potassium voltage-gated channels	KCNQ3 KCNS2	2.56e-03	40	34	2	274
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP39 CHN2	3.97e-03	50	34	2	721
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FGD4 ARHGEF18	6.83e-03	66	34	2	722
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SMCO1 BEST3 PARPBP PPEF1 PGAM2	1.99e-06	167	55	5	d78356bf0c473816dbabaee51984940bd822f84e
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SEC14L3 INTU TNC CACHD1 DNAH5	4.03e-06	193	55	5	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5-6_FEZF2_CYP26B1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9C1 SEL1L3 CHN2 PHLDB2	5.02e-05	164	55	4	902cfdb8155bb2773aa69826d5b3b810a39c8d34
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9C1 SEL1L3 CHN2 PHLDB2	5.26e-05	166	55	4	c22a97353f7eb084f768c13d7767a80b30f05043
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9C1 SEL1L3 CHN2 PHLDB2	5.26e-05	166	55	4	01544c851588f1cde05d6700c3d1167f70a0fbd5
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9C1 SEL1L3 CHN2 PHLDB2	5.39e-05	167	55	4	4e613be2b3ba01160b0c0254fce3c4f72220e580
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5-6_FEZF2_MYBPHL\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9C1 SEL1L3 CHN2 PHLDB2	5.39e-05	167	55	4	c7d1e84af1f4d7430858287520ac2cfa36203642
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9C1 SEL1L3 CHN2 PHLDB2	5.39e-05	167	55	4	18ad85751bd892309627eefc357eb28ec5a7c300
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9C1 SEL1L3 CHN2 PHLDB2	5.51e-05	168	55	4	4a2e08b047f7170ae4b95eac9b2b128e55beee4a
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9C1 SEL1L3 CHN2 PHLDB2	5.51e-05	168	55	4	3e09516e819cf140a6dbf8f85247d3f08aa35bb8
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM111A FGD4 USP25 STIL	5.64e-05	169	55	4	4db49b7eaea34e6558ee73b01e76315e99cc880b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FGD4 RAP1GAP2 KCNQ3 DNAH5	6.04e-05	172	55	4	0c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FGD4 RAP1GAP2 KCNQ3 DNAH5	6.04e-05	172	55	4	eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT17 UNC5C RAP1GAP2 CACHD1	6.18e-05	173	55	4	4bc6d93716f093b460c8b047199db8cab5fea720
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMCO1 BEST3 KCNQ3 PGAM2	6.32e-05	174	55	4	4a6e04b4f12b87c15fa1409989cbe32c43736369
ToppCell	15-Distal-Epithelial-Neuroendocrine\|Distal / Age, Tissue, Lineage and Cell class	RAP1GAP2 BEST3 CHN2 PGAM2	7.05e-05	179	55	4	bc04789f0fbd293fdcea66acba8cf227af251b7a
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC9C1 SEL1L3 KCNQ3 CACHD1	7.36e-05	181	55	4	576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT17 UNC5C RAP1GAP2 CACHD1	7.36e-05	181	55	4	e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	CYP2B6 KCNQ3 CACHD1 DNAH5	7.36e-05	181	55	4	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALNT17 TNC CHN2 PHLDB2	7.85e-05	184	55	4	9cc5c588f7c6631b3fb8a522214a09ca32947e72
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	CYP2B6 KCNQ3 CACHD1 DNAH5	8.01e-05	185	55	4	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	COVID-19-Heart-Fib_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PHLDB1 TNC PXDNL UNC5C	8.01e-05	185	55	4	8f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	CYP2B6 KCNQ3 CACHD1 DNAH5	8.01e-05	185	55	4	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	GALNT17 TNC UNC5C PHLDB2	8.35e-05	187	55	4	464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT17 UNC5C RAP1GAP2 CACHD1	8.70e-05	189	55	4	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GALNT17 TNC PXDNL UNC5C	8.70e-05	189	55	4	a153b83314cf52808f685296cff8c95af3f4983d
ToppCell	Adult\|World / Lineage, Cell type, age group and donor	FGD4 KCNQ3 PRKAG2 DNAH5	8.70e-05	189	55	4	5cd285bfad973125d46d704fec18b21266a63379
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GALNT17 TNC PXDNL UNC5C	8.70e-05	189	55	4	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GALNT17 TNC PXDNL UNC5C	9.06e-05	191	55	4	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GALNT17 TNC PXDNL UNC5C	9.25e-05	192	55	4	dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GALNT17 TNC PXDNL UNC5C	9.25e-05	192	55	4	6f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GALNT17 TNC PXDNL UNC5C	9.25e-05	192	55	4	3d0cb19f037f604253d7d728689aeaa94251e92b
ToppCell	COVID-19-lung-Secretory\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CYP2B6 SEL1L3 CACHD1 DNAH5	9.25e-05	192	55	4	59261098ccb52306f837f632ebaea45b90ad30fe
ToppCell	Control-Myeloid-cMonocyte\|Control / Disease state, Lineage and Cell class	GLT1D1 FGD4 PRKAG2 CHN2	9.25e-05	192	55	4	ad04c9c4bdebf94615cee1904ca48197e62c923b
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GALNT17 TNC PXDNL UNC5C	9.25e-05	192	55	4	deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GALNT17 TNC PXDNL UNC5C	9.43e-05	193	55	4	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GALNT17 TNC PXDNL UNC5C	9.62e-05	194	55	4	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GALNT17 TNC PXDNL UNC5C	9.62e-05	194	55	4	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	Control-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	GLT1D1 FGD4 PRKAG2 CHN2	9.62e-05	194	55	4	f852f5258617a66a4fbd56d64c7b47272e7b8b60
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FGD4 SEL1L3 RAP1GAP2 DNAH5	9.62e-05	194	55	4	6b286992d4bb56013c0ea5a7601d3476d806175a
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GALNT17 TNC PXDNL UNC5C	9.62e-05	194	55	4	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FGD4 SEL1L3 RAP1GAP2 DNAH5	9.62e-05	194	55	4	f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCell	11.5-Distal-Epithelial-Neuroendocrine\|Distal / Age, Tissue, Lineage and Cell class	RAP1GAP2 BEST3 CHN2 PGAM2	9.82e-05	195	55	4	eda6ebe52c48bd6a9044886e75f584f46c2556e7
ToppCell	COVID-19-Myeloid-Monocytes\|COVID-19 / group, cell type (main and fine annotations)	GLT1D1 FGD4 RAP1GAP2 PRKAG2	1.00e-04	196	55	4	04d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCell	COVID-19-lung-Proliferative_fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	TNC UNC5C STIL PARPBP	1.00e-04	196	55	4	2ce8a787f2731faa913d20342d73041d59468f27
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	GALNT17 TNC UNC5C PHLDB2	1.02e-04	197	55	4	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SMCO1 STIL DNAH5 DNAH1	1.02e-04	197	55	4	6e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC9C1 FGD4 KCNQ3 CACHD1	1.06e-04	199	55	4	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Neuronal-Excitatory-eD(FEZF2)-IL26---L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC9C1 SEL1L3 CHN2 PHLDB2	1.08e-04	200	55	4	37c4a5ea91251e7478f9a136015b02bcfaf3880d
ToppCell	Neuronal-Excitatory-eD(FEZF2)-IL26--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC9C1 SEL1L3 CHN2 PHLDB2	1.08e-04	200	55	4	7c594816c75ffd9d8c29f15c115f3ccf0c646371
ToppCell	Neuronal-Excitatory-eD(FEZF2)-IL26\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC9C1 SEL1L3 CHN2 PHLDB2	1.08e-04	200	55	4	6207c41384a95b793da009a1b85bd842c64256ce
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Proliferating-cycling_ventral_progenitors\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	FAM111A BEST3 STIL PARPBP	1.08e-04	200	55	4	9359faa749f41aaef70b4874f20b4eed2dc12cc2
ToppCell	Neuronal-Excitatory-eD(FEZF2)-IL26-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC9C1 SEL1L3 CHN2 PHLDB2	1.08e-04	200	55	4	a516a4b2ed1260dfa5129fef974781bed025bb34
Disease	response to methotrexate, serum alanine aminotransferase measurement	RAP1GAP2 CACHD1 ECPAS	6.42e-05	43	53	3	EFO_0004735, GO_0031427
Disease	myocardial infarction (biomarker_via_orthology)	TNC CSNK2A1 CSNK2A3 NLK	1.98e-04	160	53	4	DOID:5844 (biomarker_via_orthology)
Disease	response to thioamide, Drug-induced agranulocytosis	SEC14L3 PHLDB2	3.74e-04	16	53	2	EFO_0007633, HP_0012235
Disease	unipolar depression, response to bupropion, mood disorder	TNC NLK	5.31e-04	19	53	2	EFO_0003761, EFO_0004247, EFO_0006326
Disease	Strabismus	DNAH5 ANKRD26P1	1.25e-03	29	53	2	HP_0000486

Protein segments in the cluster

Peptide	Gene	Start	Entry
AVYKRFPTMDHVVEA	BEST3	146	Q8N1M1
PSEESQDYYHKVVIR	EP400	1281	Q96L91
YKSPMVQIYELEEHK	PRKAG2	331	Q9UGJ0
PEMYEIYTSSKEDRN	ARHGEF18	761	Q6ZSZ5
HDRAKMPYTEAVIYE	CYP2B6	341	P20813
QPETKRMVEHYTAYL	CACHD1	671	Q5VU97
IHQVMSEYKENETPR	ANKRD26P1	216	Q6NSI1
LYTVSERQPMYSREH	RBM27	421	Q9P2N5
EGYIYRHMDPVNDTK	ARHGAP39	826	Q9C0H5
TYDTHVNKTYPVDMS	GUCY2C	396	P25092
NMDVTDHYEDVRKIY	PARPBP	81	Q9NWS1
YAARDIEKHTMVIEY	KMT2C	4786	Q8NEZ4
YSITEKHYAQEDPRM	RPS6KC1	761	Q96S38
HMERLQVQVTEYYPT	KCNQ3	646	O43525
SFPEMVYYIQEKASH	ECPAS	556	Q5VYK3
VYYIQEKASHRMKTP	ECPAS	561	Q5VYK3
MKIVETQNEEYPHTF	FGD4	476	Q96M96
MKEVPSVNLRDYYAH	KCNS2	436	Q9ULS6
HMTQEVVTQYYRAPE	NLK	296	Q9UBE8
PHIVRYYDVMSDEEI	P4HA2	336	O15460
SKEEQEILYHYPMSE	INTU	321	Q9ULD6
AQYSYPVDKDMELSH	PXDNL	1321	A1KZ92
AEYISKMTTNPIYEH	CHN2	141	P52757
DTVIPYHEDFRMYIT	DNAH1	3311	Q9P2D7
YHEDFRMYITTKLPN	DNAH1	3316	Q9P2D7
REAMEHPYFYTVVKD	CSNK2A3	316	Q8NEV1
EIVVNGREYVRMYHS	GLT1D1	311	Q96MS3
VQSKKAESPEYVHMY	FAM111A	501	Q96PZ2
HMVYRISAPTQEEKD	CYTH2	351	Q99418
DHVYPEMRRYNNTVA	GALNT17	451	Q6IS24
REAMEHPYFYTVVKD	CSNK2A1	316	P68400
LMTAPEYYEFRHTQV	DALRD3	326	Q5D0E6
KSMYVRDQVKTQYEH	SEC14L3	266	Q9UDX4
EVYKGVVTEYHDMVT	NME7	286	Q9Y5B8
KRIANIIEHMTYEVY	DNAH5	3866	Q8TE73
YVVHRYEDLMKPDVT	PPEF1	636	O14829
VEREKMKSYIYVHTV	SERAC1	66	Q96JX3
PETSKYEYRVEMVHQ	TRIM37	336	O94972
VHVKFPSIMVYRDDY	SEL1L3	146	Q68CR1
YPKASQMIVSYDEHE	RAP1GAP2	241	Q684P5
LEDVTNYKMSYVAHP	SAXO1	201	Q8IYX7
YVVDIPMSTKTDIYD	SLC9C1	1031	Q4G0N8
MDEKHPYYNSISKER	PGAM2	126	P15259
ADKTHYERQMKTYIP	HMGB1P1	66	B2RPK0
SVKTHDRIYYMVAPS	PHLDB2	1216	Q86SQ0
IVLYSMTHKEPEFYE	STIL	301	Q15468
EVLVMQSEYRLHPYT	SPEN	3176	Q96T58
SPDVYQEMEASRHKV	STAU2	416	Q9NUL3
THERMQTENKISPYY	SGF29	41	Q96ES7
EMRVTEYLVVYTPTH	TNC	646	P24821
YSDKSMIQVPYRLHA	USP25	581	Q9UHP3
EHYTAKVRQMYIRDV	SMCO1	151	Q147U7
VKTHDRLYYMVAPSA	PHLDB1	1341	Q86UU1
QKIISYEEMPAYTHA	ZNF780B	141	Q9Y6R6
YVMTKHATIYPTEEE	ZFR	726	Q96KR1
YEEIMRDYIQKHPEL	UBTF	256	P17480
QGRVYEMYVTVHRKE	UNC5C	561	O95185
SVVSVEKPLDYMNHY	ZNF181	546	Q2M3W8