Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoToe clinodactyly

FRA10AC1 SATB2 HEPHL1

9.72e-062693HP:0001863
HumanPhenoClinodactyly of the 4th toe

FRA10AC1 HEPHL1

2.77e-05592HP:0011918
HumanPhenoDeviation of the 4th toe

FRA10AC1 HEPHL1

2.77e-05592HP:0010338
HumanPhenoAbnormal fourth toe morphology

FRA10AC1 HEPHL1

1.51e-041192HP:0010321
HumanPhenoClinodactyly of the 5th toe

FRA10AC1 HEPHL1

2.14e-041392HP:0001864
DomainIQ

LRRIQ3 MYO6

4.82e-0381242SM00015
DomainIQ_motif_EF-hand-BS

LRRIQ3 MYO6

5.92e-0390242IPR000048
DomainIQ

LRRIQ3 MYO6

6.30e-0393242PS50096
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

WDR35 KLHL14 ELAPOR1

1.79e-0415325310718198
Pubmed

Single-cell transcriptomic analysis of mouse neocortical development.

SATB2 NEB CTSS

2.44e-0417025330635555
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

SATB2 CPS1 MYO6 TOP2B

2.68e-0444425434795231
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

WDR35 KLHL14 MYO6 ELAPOR1

3.98e-0449325415368895
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

DHX57 MYO6 TOP2B

4.04e-0420225333005030
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

DOCK10 WDR35 TPCN1

5.53e-0422525312168954
Pubmed

Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells.

NEB MYO6

6.94e-045425222266860
CytobandEnsembl 112 genes in cytogenetic band chr2q36

DOCK10 SPHKAP

9.89e-0485252chr2q36
CoexpressionGSE13547_WT_VS_ZFX_KO_BCELL_ANTI_IGM_STIM_12H_DN

C7 KLHL14 CYP19A1 HEXIM1

1.49e-05159254M2983
CoexpressionGSE27859_MACROPHAGE_VS_CD11C_INT_F480_HI_MACROPHAGE_DN

AGFG2 LRRIQ3 SGSM2 TPCN1

2.82e-05187254M8589
CoexpressionGSE26156_DOUBLE_POSITIVE_VS_CD4_SINGLE_POSITIVE_THYMOCYTE_UP

CASP4 TMEM131L SGSM2 HEXIM1

3.60e-05199254M8298
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial-Proteoglycan-expressing_cell|GW16 / Sample Type, Dataset, Time_group, and Cell type.

AGFG2 CASP4 ZNF81 NEB CTSS

8.16e-08200255da45a85a4667965b24ba824af871157af5b4cd19
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial|GW16 / Sample Type, Dataset, Time_group, and Cell type.

AGFG2 CASP4 ZNF81 NEB CTSS

8.16e-0820025525f4c051c2e869481f33c22ad54de97efac444ad
ToppCellmild_COVID-19_(asymptomatic)-NK_CD56bright|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

WDR35 CPS1 NEB SGSM2

1.46e-061512542470162f4b56bc505db166a6eb0fa54847759df8
ToppCellrenal_papilla_nuclei-Adult_normal_reference|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK10 AGFG2 C7 TPCN1

3.79e-061922546c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col18a1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SATB2 C7 NEB

7.61e-05148253fc80c02b51cf55a04ce550838ee2f41d8f656f41
ToppCellmild_COVID-19_(asymptomatic)-NK_CD56bright|World / disease group, cell group and cell class (v2)

WDR35 NEB SGSM2

8.39e-05153253aff5c8ab1fb4ebc324cec02cf562b7484bb10db8
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPS1 HEPHL1 SPHKAP

9.58e-05160253c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPS1 HEPHL1 SPHKAP

9.58e-0516025325c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellPND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DOCK10 AGFG2 SGSM2

9.76e-0516125376c993a4533362db2250c88b3ee3ede55362d54e
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CPS1 HEPHL1 NEB

9.94e-05162253bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellControl-B_cells-Activated_B_cells|Control / group, cell type (main and fine annotations)

DOCK10 TMEM131L KLHL14

1.11e-04168253a7159a35fe37f8c241cf8d391debe271e0698105
ToppCellCOVID-19-kidney-Bcells|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK10 TMEM131L KLHL14

1.17e-041712538e8fb79968b1a5c34d1d9cad7f9155fabfdb7cc7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic-Neutrophil|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRRIQ3 CTSS ELAPOR1

1.27e-04176253676839d07450b313222622e0ffd305c732cbad6d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK10 TMEM131L CTSS

1.36e-0418025365c069585737302a69b9a01476f4eb8b50cb2bfd
ToppCelldroplet-Spleen-nan-18m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK10 CTSS TOP2B

1.40e-04182253eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCellCOVID-19-lung-B_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK10 TMEM131L KLHL14

1.47e-04185253e8f1ad580f19705b5ca1d7d8867b2125f4891684
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK10 TMEM131L CTSS

1.52e-04187253edad646d5eb1d70b768dc21fe02ef5265214e8e6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK10 TMEM131L CTSS

1.52e-041872538fa454dc4e6a3e8e2bb2ad803acc579e0d3f76da
ToppCellwk_20-22-Hematologic_Lymphocytic-B-small_pre-B-II_cell|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

TMEM131L KLHL14 TOP2B

1.59e-04190253f49ceda3622cf079cffde9c9a9e3d0380c571d39
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SATB2 CPS1 ELAPOR1

1.62e-04191253a8d77095ba20b47fc70ba04f80759fbce873253d
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM131L KLHL14 TOP2B

1.69e-041942537ee8ac172c2dee7df7dc4eb222e0985a0089bda8
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM131L KLHL14 TOP2B

1.69e-0419425311709704079f24a730476572dc2f01e9d2226e2c
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM131L KLHL14 TOP2B

1.69e-041942533a1f95639d5f239f001bd67d4213e8938e7f299d
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK10 C7 SPHKAP

1.69e-04194253a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCellproximal-Hematologic-Natural_Killer_T-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DOCK10 TMEM131L TOP2B

1.72e-041952534d7c2c4d0130c2d46877ff6dd4584525d8f74daf
ToppCellproximal-3-Hematologic-Natural_Killer_T|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DOCK10 TMEM131L TOP2B

1.72e-0419525393093545bb23d2619ace029a52cffa1f673a0c2a
ToppCellproximal-Hematologic-Natural_Killer_T|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DOCK10 TMEM131L TOP2B

1.72e-041952533944e4800f5d904d4efa401ce8913ec0e0781211
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK10 CTSS TPCN1

1.77e-0419725310190b877bf46ba2163d203df9dd3b498c66e52f
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DOCK10 C7 SPHKAP

1.77e-041972530034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DOCK10 C7 SPHKAP

1.77e-0419725311a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellChildren_(3_yrs)-Immune|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK10 TMEM131L CTSS

1.77e-04197253f18807124b91310fcd84238484a80ecdba684679
ToppCellPCW_10-12|World / Celltypes from embryonic and fetal-stage human lung

DOCK10 CASP4 C7

1.77e-0419725347fd8b0d596c5db1a722473c8efbb17a6bbe7538
ToppCell3'-Child04-06-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CPS1 MYO6 ELAPOR1

1.80e-04198253a4543d636501a1b5b46c14a661ce9d169947c82c
ToppCell3'-Child04-06-SmallIntestine-Epithelial-epithelial_progenitor_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CPS1 MYO6 ELAPOR1

1.80e-04198253e8bfae3888b2406b5629b576cb02913b3297337e
ToppCell5'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CPS1 MYO6 ELAPOR1

1.85e-04200253fc77a0c53201c60933d188ea8d4d86bac6325422
ToppCell5'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CPS1 MYO6 ELAPOR1

1.85e-04200253742441800a2d167c19cee4816ff77424ae6675c6
DrugDehydroepiandrosterone

CPS1 CTSS TOP2B CYP19A1

1.61e-05141254ctd:D003687
DrugTimolol maleate salt [26921-17-5]; Up 200; 9.2uM; MCF7; HT_HG-U133A

DOCK10 AGFG2 CASP4 CPS1

6.08e-051982545645_UP
DrugMetixene hydrochloride [1553-34-0]; Down 200; 11.6uM; HL60; HT_HG-U133A

DOCK10 AGFG2 CASP4 TPCN1

6.20e-051992542451_DN
Drugazathioprine, USP; Down 200; 100uM; MCF7; HG-U133A

AGFG2 MYO6 HEXIM1 ELAPOR1

6.32e-05200254338_DN
DrugCompound-1

CTSS TOP2B CYP19A1

2.94e-04119253CID006324619
Drugbendiocarb

MYO6 TOP2B

4.30e-0428252CID000002314
Drugtubulin polymerization inhibitor

CASP4 HEXIM1 TPCN1

4.94e-04142253CID010125800
Drugcompound 20

CTSS CYP19A1

6.36e-0434252CID000448214
DrugWR-1065

CASP4 TOP2B

6.36e-0434252CID000104807
DrugHMBA

CASP4 HEXIM1 TPCN1

6.62e-04157253CID000003616
Drugpregnanetriol

MYO6 CYP19A1

7.13e-0436252CID000101967
Drugvalproate

CPS1 MYO6 CYP19A1 TPCN1

7.39e-04381254CID000003121
Drugalternariol

TOP2B CYP19A1

7.94e-0438252ctd:C005197
Drugfelodipine

TOP2B CYP19A1 TPCN1

8.19e-04169253CID000003333
Drug21-deoxycortisol

MYO6 CYP19A1

8.37e-0439252CID000092827
DrugThiostrepton [1393-48-2]; Down 200; 2.4uM; HL60; HT_HG-U133A

DOCK10 CPS1 TPCN1

9.37e-041772532462_DN
DrugMENT

MYO6 CYP19A1

9.70e-0442252CID000019582
DrugAzaguanine-8 [134-58-7]; Down 200; 26.2uM; PC3; HT_HG-U133A

DOCK10 DHX57 HEXIM1

9.99e-041812531791_DN
Drugnifedipine

MYO6 TOP2B CYP19A1 TPCN1

1.02e-03415254CID000004485
DrugSecurinine [5610-40-2]; Up 200; 18.4uM; MCF7; HT_HG-U133A

DOCK10 CASP4 CPS1

1.08e-031862536831_UP
DiseaseLiver Cirrhosis, Experimental

DOCK10 CASP4 C7 CPS1 CTSS HEXIM1

3.69e-05774256C0023893
Diseaseovarian cancer (is_implicated_in)

MYO6 CYP19A1

1.03e-0356252DOID:2394 (is_implicated_in)
DiseaseIGA glomerulonephritis

DOCK10 SPHKAP

1.11e-0358252EFO_0004194
Diseaseplatelet measurement

DOCK10 TMEM131L CPS1

2.33e-03315253EFO_0005036
Diseasebeta-amyloid 1-42 measurement

FRA10AC1 CYP19A1

2.47e-0387252EFO_0004670

Protein segments in the cluster

PeptideGeneStartEntry
NWKEEEKKKYYDAKT

CASP4

36

P49662
WKKNQKLEYKYSKLV

ELAPOR1

931

Q6UXG2
PYYKLTWEEKKKFDE

HEXIM1

166

O94992
TWEKRLAKKYYDKLF

FRA10AC1

126

Q70Z53
EIEKLTYIDKWFLYK

CPS1

866

P31327
LVQYYDDEKKTWKIL

KLHL14

341

Q9P2G3
AEYLKRKGYWKVEKI

DOCK10

1731

Q96BY6
LYLKYWELVVELKKF

CCDC127

236

Q96BQ5
KISWLYKKYEKSVKD

CYP19A1

236

P11511
YVNLKKKISKRYDWQ

DHX57

496

Q6P158
VKKLYLKWALEEYLD

C7

436

P10643
ESWYLDDNIKKYLNK

HEPHL1

936

Q6MZM0
WKKTYGKQYKEKNEE

CTSS

31

P25774
KEKWLYALEDKYINK

SPHKAP

261

Q2M3C7
KHIENQKAWKIKYYK

TOP2B

621

Q02880
SELANKLYERWKKYK

TMEM131L

536

A2VDJ0
KLYERWKKYKNGDVC

TMEM131L

541

A2VDJ0
DVWSKYQKDKKNYKE

SGSM2

541

O43147
EFGRWYKKYKKIKVE

SATB2

221

Q9UPW6
VKEFLQEKYEKKRWY

AGFG2

131

O95081
DIYEVAALKWKAKKN

TPCN1

401

Q9ULQ1
WDTKNNEKYVKYVKG

WDR35

361

Q9P2L0
LNKKILNTEWDYEYK

ZNF81

156

P51508
KWIYITKGYEDKLLK

LRRIQ3

256

A6PVS8
TKKYDLSKWKYAELR

MYO6

1081

Q9UM54
LYKQNWEDTKDKYLL

NEB

171

P20929
KYKEDYENKIKGKWS

NEB

276

P20929