Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	FOXD2 MSX1 ZNF668 FOXO6 TFAP2E PATZ1 GLIS2 ZBTB9 ZFHX2 RELA NOTO CHD7 FOXA3 ZNF865 GSC2 NOTCH1	4.34e-05	1271	81	16	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	FOXD2 MSX1 ZNF668 FOXO6 TFAP2E PATZ1 GLIS2 ZBTB9 ZFHX2 PLAGL2 RELA NOTO BARX1 FOXA3 GSC2 NOTCH1	1.50e-04	1412	81	16	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	FOXD2 MSX1 ZNF668 FOXO6 TFAP2E PATZ1 GLIS2 ZBTB9 ZFHX2 RELA NOTO CHD7 BARX1 FOXA3 ZNF865 GSC2	2.18e-04	1459	81	16	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXD2 MSX1 ZNF668 TFAP2E PATZ1 GLIS2 PLAGL2 RELA NOTCH1	4.36e-04	560	81	9	GO:0001228
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXD2 ZNF668 FOXO6 TFAP2E PATZ1 GLIS2 ZBTB9 ZFHX2 RELA NOTO CHD7 FOXA3 ZNF865 GSC2	4.42e-04	1244	81	14	GO:0000978
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	FOXD2 MSX1 ZNF668 TFAP2E PATZ1 GLIS2 PLAGL2 RELA NOTCH1	4.71e-04	566	81	9	GO:0001216
GeneOntologyBiologicalProcess	embryonic hindlimb morphogenesis	MSX1 SHH CHD7 NOTCH1	1.00e-05	35	80	4	GO:0035116
GeneOntologyBiologicalProcess	nerve growth factor signaling pathway	NTF4 RAPGEF1 RAPGEF2	1.98e-05	14	80	3	GO:0038180
GeneOntologyBiologicalProcess	hindlimb morphogenesis	MSX1 SHH CHD7 NOTCH1	3.89e-05	49	80	4	GO:0035137
MousePheno	abnormal neural tube morphology	MSX1 RBM12 PATZ1 PKD1 SHH RAPGEF1 NOTO CHD7 RAPGEF2 MBD6 NOTCH1 KIF7	9.08e-06	591	62	12	MP:0002151
MousePheno	dilated third ventricle	MSX1 CELSR2 PKD1 CHD7	1.47e-05	34	62	4	MP:0000827
Domain	hEGF	CELSR2 FBN3 NOTCH1	2.38e-04	28	81	3	PF12661
Domain	-	COL19A1 CELSR2 SHBG LMAN2	7.75e-04	95	81	4	2.60.120.200
Domain	TF_fork_head_CS_1	FOXD2 FOXO6 FOXA3	1.11e-03	47	81	3	IPR018122
Domain	FH	FOXD2 FOXO6 FOXA3	1.25e-03	49	81	3	SM00339
Domain	FORK_HEAD_1	FOXD2 FOXO6 FOXA3	1.25e-03	49	81	3	PS00657
Domain	FORK_HEAD_2	FOXD2 FOXO6 FOXA3	1.25e-03	49	81	3	PS00658
Domain	Fork_head_dom	FOXD2 FOXO6 FOXA3	1.25e-03	49	81	3	IPR001766
Domain	FORK_HEAD_3	FOXD2 FOXO6 FOXA3	1.25e-03	49	81	3	PS50039
Domain	Forkhead	FOXD2 FOXO6 FOXA3	1.25e-03	49	81	3	PF00250
Domain	Laminin_G	COL19A1 CELSR2 SHBG	2.04e-03	58	81	3	IPR001791
Domain	ConA-like_dom	COL19A1 CELSR2 SHBG LMAN2 MDGA1	2.63e-03	219	81	5	IPR013320
Domain	RasGEFN	RAPGEF1 RAPGEF2	3.36e-03	20	81	2	SM00229
Domain	Homeobox	MSX1 ZFHX2 NOTO BARX1 GSC2	3.50e-03	234	81	5	PF00046
Domain	HOMEOBOX_1	MSX1 ZFHX2 NOTO BARX1 GSC2	3.63e-03	236	81	5	PS00027
Domain	HOX	MSX1 ZFHX2 NOTO BARX1 GSC2	3.69e-03	237	81	5	SM00389
Domain	RasGEF_N	RAPGEF1 RAPGEF2	3.70e-03	21	81	2	PF00618
Domain	HOMEOBOX_2	MSX1 ZFHX2 NOTO BARX1 GSC2	3.83e-03	239	81	5	PS50071
Domain	Homeobox_dom	MSX1 ZFHX2 NOTO BARX1 GSC2	3.83e-03	239	81	5	IPR001356
Domain	Ras-like_Gua-exchang_fac_N	RAPGEF1 RAPGEF2	4.06e-03	22	81	2	IPR000651
Domain	RASGEF_NTER	RAPGEF1 RAPGEF2	4.06e-03	22	81	2	PS50212
Pubmed	Primary cilia in murine palatal rugae development.	CELSR2 SHH BARX1 NOTCH1	2.34e-07	23	81	4	31226309
Pubmed	A dual role for Ikk alpha in tooth development.	MSX1 SHH BARX1 NOTCH1	3.92e-07	26	81	4	14960276
Pubmed	Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate.	MSX1 SHH BARX1 NOTCH1	5.36e-07	28	81	4	19782673
Pubmed	Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition.	MSX1 SHH BARX1	1.01e-06	9	81	3	9428417
Pubmed	Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis.	MSX1 SHH BARX1	1.01e-06	9	81	3	24173808
Pubmed	ISLET1-Dependent β-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw.	FOXD2 MSX1 SHH BARX1	1.35e-06	35	81	4	28069742
Pubmed	A dosage-dependent role for Spry2 in growth and patterning during palate development.	MSX1 SHH BARX1	1.44e-06	10	81	3	17693063
Pubmed	The mutation in Chd7 causes misexpression of Bmp4 and developmental defects in telencephalic midline.	MSX1 SHH CHD7	1.44e-06	10	81	3	22658483
Pubmed	Developmental stalling and organ-autonomous regulation of morphogenesis.	MSX1 SHH BARX1	1.98e-06	11	81	3	22084104
Pubmed	Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood.	MSX1 SHH BARX1	1.98e-06	11	81	3	19429790
Pubmed	Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development.	FZD4 MSX1 SHH	1.98e-06	11	81	3	18948417
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	CELSR2 NTF4 PATZ1 GLIS2 SHH ZFHX2 NOTCH1	2.07e-06	251	81	7	29031500
Pubmed	A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development.	MSX1 SHH BARX1	2.64e-06	12	81	3	26745863
Pubmed	Desmoglein 2 regulates cardiogenesis by restricting hematopoiesis in the developing murine heart.	DES DSG2 NOTCH1	3.42e-06	13	81	3	34737300
Pubmed	Developmental plasticity of epithelial stem cells in tooth and taste bud renewal.	MSX1 SHH BARX1	3.42e-06	13	81	3	31427537
Pubmed	Shh and Gli3 activities are required for timely generation of motor neuron progenitors.	MSX1 SHH NOTCH1	4.35e-06	14	81	3	19433083
Pubmed	Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis.	MSX1 SHH NOTCH1	4.35e-06	14	81	3	20123092
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	DES FOXO6 PLEKHG4 PATZ1 RELA SPAG9 TOMM40 BARX1 FOXA3 NOTCH1 KIF7	4.81e-06	857	81	11	25609649
Pubmed	Disrupted Hypothalamo-Pituitary Axis in Association With Reduced SHH Underlies the Pathogenesis of NOTCH-Deficiency.	SHH NOTCH1	5.36e-06	2	81	2	32403133
Pubmed	Synergistic association of Notch and NFκB signaling and role of Notch signaling in modulating epithelial to mesenchymal transition in colorectal adenocarcinoma.	RELA NOTCH1	5.36e-06	2	81	2	25257945
Pubmed	Notch1 expression, which is related to p65 Status, is an independent predictor of prognosis in colorectal cancer.	RELA NOTCH1	5.36e-06	2	81	2	21771876
Pubmed	Effects of Celastrol on growth inhibition of U937 leukemia cells through the regulation of the Notch1/NF-kappaB signaling pathway in vitro.	RELA NOTCH1	5.36e-06	2	81	2	20346213
Pubmed	Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth.	RAPGEF1 RAPGEF2	5.36e-06	2	81	2	17724123
Pubmed	Microvascular retinal endothelial and pericyte cell apoptosis in vitro: role of hedgehog and Notch signaling.	SHH NOTCH1	5.36e-06	2	81	2	21498615
Pubmed	The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition.	MSX1 SHH BARX1	6.67e-06	16	81	3	19591819
Pubmed	Smad4 is required to regulate the fate of cranial neural crest cells.	MSX1 SHH BARX1	6.67e-06	16	81	3	17964566
Pubmed	Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation.	MSX1 SHH BARX1	8.08e-06	17	81	3	25626636
Pubmed	Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect.	MSX1 SHH BARX1	8.08e-06	17	81	3	24785830
Pubmed	ISL1/SHH/CXCL12 signaling regulates myogenic cell migration during mouse tongue development.	FOXD2 DES SHH	8.08e-06	17	81	3	36196625
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXD2 MSX1 TFAP2E PATZ1 ZFHX2 PLAGL2 RELA NOTO BARX1 FOXA3 GSC2	8.29e-06	908	81	11	19274049
Pubmed	Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the β-catenin pathway.	MSX1 SHH BARX1	9.68e-06	18	81	3	24424161
Pubmed	Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling.	MSX1 SHH BARX1	9.68e-06	18	81	3	18634775
Pubmed	Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition.	MSX1 SHH BARX1	9.68e-06	18	81	3	9716414
Pubmed	Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia.	FOXD2 MSX1 SHH	1.15e-05	19	81	3	15107405
Pubmed	BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor.	MSX1 SHH NOTCH1	1.15e-05	19	81	3	22629441
Pubmed	A Wnt/Notch/Pax7 signaling network supports tissue integrity in tongue development.	DES SHH NOTCH1	1.15e-05	19	81	3	28438836
Pubmed	Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis.	MSX1 SHH BARX1	1.57e-05	21	81	3	32855417
Pubmed	Expression and regulation of the Msx1 natural antisense transcript during development.	MSX1 BARX1	1.60e-05	3	81	2	16157866
Pubmed	Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics.	SHH KIF7	1.60e-05	3	81	2	21633164
Pubmed	Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors.	SHH NOTCH1	1.60e-05	3	81	2	21379383
Pubmed	nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM).	RAPGEF1 RAPGEF2	1.60e-05	3	81	2	10548487
Pubmed	Caveolin-1 mediates chemoresistance in cisplatin-resistant ovarian cancer cells by targeting apoptosis through the Notch-1/Akt/NF-κB pathway.	RELA NOTCH1	1.60e-05	3	81	2	26503358
Pubmed	Ectopic expression of Fgf-4 in chimeric mouse embryos induces the expression of early markers of limb development in the lateral ridge.	MSX1 SHH	1.60e-05	3	81	2	8792609
Pubmed	Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1.	RAPGEF1 RAPGEF2	1.60e-05	3	81	2	17826737
Pubmed	[Novel signal transduction pathways: the molecular basis for targeted cancer therapies in Hedgehog/Notch/Wnt pathway].	SHH NOTCH1	1.60e-05	3	81	2	26281688
Pubmed	T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells.	RELA NOTCH1	1.60e-05	3	81	2	8642313
Pubmed	Novel roles for Notch, Wnt and Hedgehog in hematopoesis derived from human pluripotent stem cells.	SHH NOTCH1	1.60e-05	3	81	2	20336604
Pubmed	Differential expression of Hedgehog/Notch and transforming growth factor-β in human abdominal aortic aneurysms.	SHH NOTCH1	1.60e-05	3	81	2	24768363
Pubmed	Production of proinflammatory mediators in activated microglia is synergistically regulated by Notch-1, glycogen synthase kinase (GSK-3β) and NF-κB/p65 signalling.	RELA NOTCH1	1.60e-05	3	81	2	29049420
Pubmed	Andrographolide exerts anti-inflammatory effects in Mycobacterium tuberculosis-infected macrophages by regulating the Notch1/Akt/NF-κB axis.	RELA NOTCH1	1.60e-05	3	81	2	32991757
Pubmed	Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A.	SHH NOTCH1	1.60e-05	3	81	2	19407245
Pubmed	Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling.	RAPGEF1 NOTCH1	1.60e-05	3	81	2	18180377
Pubmed	Molecular cross talk between Notch1, Shh and Akt pathways during erythroid differentiation of K562 and HEL cell lines.	SHH NOTCH1	1.60e-05	3	81	2	24095799
Pubmed	Interactions between Bmp-4 and Msx-1 act to restrict gene expression to odontogenic mesenchyme.	MSX1 BARX1	1.60e-05	3	81	2	9707326
Pubmed	Krüppel-like factor 9 deficiency in uterine endometrial cells promotes ectopic lesion establishment associated with activated notch and hedgehog signaling in a mouse model of endometriosis.	SHH NOTCH1	1.60e-05	3	81	2	24476135
Pubmed	Eliminating Cancer Stem Cells by Targeting Embryonic Signaling Pathways.	SHH NOTCH1	1.60e-05	3	81	2	27730468
Pubmed	TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner.	MSX1 SHH BARX1	2.08e-05	23	81	3	18572160
Pubmed	BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis.	MSX1 SHH BARX1	2.70e-05	25	81	3	24631216
Pubmed	Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis.	MSX1 SHH NOTCH1	3.04e-05	26	81	3	23754280
Pubmed	Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.	SHH NOTCH1	3.20e-05	4	81	2	26999738
Pubmed	Notch signaling is not essential in sonic hedgehog-activated medulloblastoma.	SHH NOTCH1	3.20e-05	4	81	2	20440271
Pubmed	A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ.	MSX1 SHH	3.20e-05	4	81	2	10704389
Pubmed	Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development.	MSX1 SHH	3.20e-05	4	81	2	23720046
Pubmed	Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis.	MSX1 SHH	3.20e-05	4	81	2	12163415
Pubmed	Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion.	NTF4 SHH	3.20e-05	4	81	2	28566470
Pubmed	Patterning of the murine dentition by homeobox genes.	MSX1 BARX1	3.20e-05	4	81	2	9541203
Pubmed	Cancer stem cells and hepatocellular carcinoma.	SHH NOTCH1	3.20e-05	4	81	2	19901516
Pubmed	Msx1 is close but not allelic to either Hm or Hx on mouse chromosome 5.	MSX1 SHH	3.20e-05	4	81	2	7919658
Pubmed	Embryonic tongue morphogenesis in an organ culture model of mouse mandibular arches: blocking Sonic hedgehog signaling leads to microglossia.	DES SHH	3.20e-05	4	81	2	26334330
Pubmed	Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.	SHH FOXA3 NOTCH1	3.42e-05	27	81	3	21791528
Pubmed	Excess neuropeptides in lung signal through endothelial cells to impair gas exchange.	SHH FOXA3 NOTCH1	3.42e-05	27	81	3	35303432
Pubmed	p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation.	MSX1 SHH NOTCH1	4.72e-05	30	81	3	16524929
Pubmed	The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling.	MSX1 SHH NOTCH1	5.22e-05	31	81	3	22508726
Pubmed	Polycystin-1 interacts with intermediate filaments.	DES PKD1	5.33e-05	5	81	2	11581269
Pubmed	The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse.	SHH NOTCH1	5.33e-05	5	81	2	9441674
Pubmed	Developmental pathways in breast cancer and breast tumor-initiating cells: therapeutic implications.	SHH NOTCH1	5.33e-05	5	81	2	22123293
Pubmed	Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis.	FOXD2 SHH	5.33e-05	5	81	2	9510020
Pubmed	Double labeling for whole-mount in situ hybridization in mouse.	MSX1 SHH	5.33e-05	5	81	2	9631179
Pubmed	Dll3 and Notch1 genetic interactions model axial segmental and craniofacial malformations of human birth defects.	BARX1 NOTCH1	5.33e-05	5	81	2	17849441
Pubmed	The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways.	SHH NOTCH1	5.33e-05	5	81	2	26592459
Pubmed	Mesodermal development in mouse embryos mutant for fibronectin.	SHH NOTCH1	5.33e-05	5	81	2	8906418
Pubmed	Unusual pattern of Sonic hedgehog expression in the polydactylous mouse mutant Hemimelic extra-toes.	MSX1 SHH	5.33e-05	5	81	2	12455636
Pubmed	Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ.	MSX1 SHH	5.33e-05	5	81	2	10340755
Pubmed	Novel roles of Fgfr2 in AER differentiation and positioning of the dorsoventral limb interface.	MSX1 SHH	5.33e-05	5	81	2	14507786
Pubmed	FilaminA and Formin2 regulate skeletal, muscular, and intestinal formation through mesenchymal progenitor proliferation.	DES FMN2	5.33e-05	5	81	2	29240780
Pubmed	The transcriptional control of trunk neural crest induction, survival, and delamination.	MSX1 SHH NOTCH1	6.91e-05	34	81	3	15691760
Pubmed	Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation.	SHH NOTO NOTCH1	7.55e-05	35	81	3	25813538
Pubmed	Sonic hedgehog is a survival factor for hypaxial muscles during mouse development.	DES SHH	7.99e-05	6	81	2	11171399
Pubmed	Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4.	MSX1 SHH	7.99e-05	6	81	2	9268572
Pubmed	Flrt2 and Flrt3 have overlapping and non-overlapping expression during craniofacial development.	MSX1 SHH	7.99e-05	6	81	2	19635589
Pubmed	GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium.	SHH NOTCH1	7.99e-05	6	81	2	34698766
Pubmed	Spatio-temporal expression of Pbx3 during mouse organogenesis.	MSX1 NOTCH1	7.99e-05	6	81	2	16434237
Pubmed	Hoxa2 plays a direct role in murine palate development.	MSX1 BARX1	7.99e-05	6	81	2	19653318
Pubmed	HIV-1 subtypes B and C Tat differentially impact synaptic plasticity expression and implicates HIV-associated neurocognitive disorders.	NTF4 RELA ADCY1	9.68e-05	38	81	3	25613138
Pubmed	Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.	SHH CHD7 KIF7	1.05e-04	39	81	3	25859222
Pubmed	Chromatin remodeler CHD7 is critical for cochlear morphogenesis and neurosensory patterning.	SHH CHD7	1.12e-04	7	81	2	34004180
Pubmed	Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.	RAPGEF1 RAPGEF2	1.12e-04	7	81	2	21840392
Pubmed	Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4.	MSX1 SHH	1.12e-04	7	81	2	11180951
Pubmed	Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice.	SHH NOTCH1	1.12e-04	7	81	2	9531541
Pubmed	Gpr177-mediated Wnt Signaling Is Required for Secondary Palate Development.	MSX1 SHH	1.12e-04	7	81	2	25922332
GeneFamily	Forkhead boxes	FOXD2 FOXO6 FOXA3	2.86e-04	43	54	3	508
GeneFamily	NKL subclass homeoboxes and pseudogenes	MSX1 NOTO BARX1	1.05e-03	67	54	3	519
Coexpression	BENPORATH_EED_TARGETS	FOXD2 MSX1 COL4A6 EFNA3 ADRB3 COL19A1 TFAP2E TMEM65 SHH ADAMTS18 BARX1 MDGA1 GSC2 LRRC47	4.13e-06	1059	81	14	M7617
Coexpression	BENPORATH_PRC2_TARGETS	FOXD2 MSX1 COL4A6 EFNA3 ADRB3 TFAP2E SHH ADAMTS18 BARX1 GSC2	3.16e-05	650	81	10	M8448
Coexpression	GSE32986_CURDLAN_LOWDOSE_VS_CURDLAN_HIGHDOSE_STIM_DC_DN	FAM20C PNRC1 PLAGL2 RELA RAPGEF2 RAVER1	3.69e-05	200	81	6	M8635
Coexpression	MEISSNER_NPC_ICP_WITH_H3_UNMETHYLATED	EPN3 PLEKHG4 TNFRSF13C	4.82e-05	23	81	3	M1937
Coexpression	MEISSNER_NPC_ICP_WITH_H3_UNMETHYLATED	EPN3 PLEKHG4 TNFRSF13C	4.82e-05	23	81	3	MM821
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000_k-means-cluster#4	MSX1 DSG2 TMEM65 BARX1 KIF7 LRRC47	4.12e-06	112	80	6	Facebase_RNAseq_e10.5_Maxillary Arch_1000_K4
CoexpressionAtlas	gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K0	FOXD2 FZD4 ZNF668 FAM20C RBM12 CELSR2 SYT3 PATZ1 GLIS2 ZBTB9 ZFHX2 FAM89B PLAGL2 CHD7 MBD6 ZNF865 MFSD3	4.25e-06	1275	80	17	gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K0
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000	MSX1 UBQLN1 OSTM1 SYT3 DSG2 TMEM65 PNRC1 SRSF11 TSEN54 CHD7 BARX1 KIF7 LRRC47	7.78e-05	989	80	13	Facebase_RNAseq_e10.5_Maxillary Arch_1000
CoexpressionAtlas	facebase_RNAseq_e10.5_OlfacPit_2500	EPN3 MSX1 ZNF668 FAM20C EFNA3 CELSR2 OSTM1 SYT3 DSG2 NTF4 PATZ1 DUSP8 ADAMTS18 ZFHX2 TOMM40 CHD7	8.79e-05	1453	80	16	facebase_RNAseq_e10.5_OlfacPit_2500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#3	RBM12 UBQLN1 DSG2 TMEM65 TSEN54 MBD6 BARX1 KIF7 LRRC47	9.50e-05	491	80	9	Facebase_RNAseq_e10.5_Maxillary Arch_2500_K3
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Intermediate\|10w / Sample Type, Dataset, Time_group, and Cell type.	FZD4 DES ZBTB9 ALPK1 SLC23A1 RAVER1	1.76e-06	200	81	6	e5a8647c47a49c8c90c78d681193946de103d8ff
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	COL4A6 ZNF668 NTF4 TNFRSF13C ZNF865	1.56e-05	172	81	5	58eaadf12366701103a0d1f133462c9495fedc30
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	COL4A6 ZNF668 NTF4 TNFRSF13C ZNF865	1.56e-05	172	81	5	4483073469001770015526303772fd54906c5d68
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DES FAM20C COL19A1 SPAG9 PLBD2	2.21e-05	185	81	5	29d7ddcb9a2e45f76cd5611f7c52b6df689effd3
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DES FAM20C COL19A1 SPAG9 PLBD2	2.21e-05	185	81	5	780bdb63ef913a09930063286011c9108381d3a9
ToppCell	Macroglial-Astrocytes-GFAP---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	MSX1 MAN1A1 ADAMTS18 FMN2 MDGA1	3.22e-05	200	81	5	88d66550781a3c9102ff7455f5cff6fb072943cd
ToppCell	Macroglial-Astrocytes-GFAP-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	MSX1 MAN1A1 ADAMTS18 FMN2 MDGA1	3.22e-05	200	81	5	d6a059b0ef763c281c60b1ac76da6079ea822f80
ToppCell	Macroglial-Astrocytes-GFAP--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	MSX1 MAN1A1 ADAMTS18 FMN2 MDGA1	3.22e-05	200	81	5	16269fa4adb28fc6ed032bbdba8781237dd0d249
ToppCell	Macroglial-Astrocytes-GFAP----L1-2\|Macroglial / cells hierarchy compared to all cells using T-Statistic	MSX1 MAN1A1 ADAMTS18 FMN2 MDGA1	3.22e-05	200	81	5	c6f43bbbd5df5f2c19ae385f1a6b6a330abede2f
ToppCell	Macroglial-Astrocytes-GFAP\|Macroglial / cells hierarchy compared to all cells using T-Statistic	MSX1 MAN1A1 ADAMTS18 FMN2 MDGA1	3.22e-05	200	81	5	79634b1086934412ae92f259ab43554ce545008f
Disease	autism spectrum disorder (is_marker_for)	SHH SRSF11	1.51e-04	7	80	2	DOID:0060041 (is_marker_for)
Disease	Ependymoma	ZNF668 RELA	2.01e-04	8	80	2	C0014474
Disease	Cleft palate, isolated	FZD4 MSX1 KIF7	2.04e-04	42	80	3	C1837218
Disease	verbal-numerical reasoning measurement	FOXO6 CACNA1I NOTO FBN3	4.52e-04	131	80	4	EFO_0008394
Disease	Connective Tissue Diseases	PKD1 NOTCH1	5.55e-04	13	80	2	C0009782
Disease	cleft lip (is_implicated_in)	MSX1 KIF7	7.45e-04	15	80	2	DOID:9296 (is_implicated_in)
Disease	IGF-1 measurement, IGFBP-3 measurement	CELSR2 ADCY1	9.61e-04	17	80	2	EFO_0004626, EFO_0004627
Disease	neuroticism measurement, wellbeing measurement, depressive symptom measurement	MAN1A1 COL19A1	1.20e-03	19	80	2	EFO_0007006, EFO_0007660, EFO_0007869
Disease	Cleft Palate	FZD4 MSX1 KIF7	1.41e-03	81	80	3	C0008925
Disease	progranulin measurement	UBQLN1 CELSR2	1.62e-03	22	80	2	EFO_0004625
Disease	alcohol use disorder (implicated_via_orthology)	PSD SMARCD2 ADCY1 NOTCH1	1.98e-03	195	80	4	DOID:1574 (implicated_via_orthology)
Disease	body fat percentage, high density lipoprotein cholesterol measurement	SHBG TOMM40	2.09e-03	25	80	2	EFO_0004612, EFO_0007800
Disease	vitamin D measurement	EFNA3 FOXO6 CELSR2 INSC C2CD4D	2.22e-03	336	80	5	EFO_0004631
Disease	prostate carcinoma in situ (is_marker_for)	FZD4 RELA	2.62e-03	28	80	2	DOID:8634 (is_marker_for)
Disease	corpus callosum central volume measurement	DUSP8 SHH	2.62e-03	28	80	2	EFO_0010296

Protein segments in the cluster

Peptide	Gene	Start	Entry
GELLPGLFGEPGPLG	BRAT1	96	Q6PJG6
GVPGLPALSGVPGAL	COL4A6	386	Q14031
PALSGVPGALGPQGF	COL4A6	391	Q14031
LQGPAGLPGAPGISL	COL4A6	1236	Q14031
HGLSALSAPGLPGPG	DUSP8	486	Q13202
SPALGLAGGPVGAPL	EPN3	556	Q9H201
GGSFLGPPLPGASIQ	FBXO10	386	Q9UK96
PPGLGDPGSLFLEGQ	CELSR2	2696	Q9HCU4
ALGGPSLVPGPAFLA	ADRB3	316	P13945
PLLPGHPGLFPGLLG	FBN3	351	Q75N90
SMFLPPGLGGLTLPG	CHD7	2906	Q9P2D1
PGLGGLTLPGFPALA	CHD7	2911	Q9P2D1
FPAAGSGPPRGLAGL	ADAMTS18	11	Q8TE60
GIFLAPGAGLLEGAP	ALPK1	681	Q96QP1
ADAPLGLPGLAAAPG	TFAP2E	151	Q6VUC0
GLPGVGLPSAGLPGA	RBM12	656	Q9NTZ6
GLPSAGLPGAGLPST	RBM12	661	Q9NTZ6
ANPLLGELPAGGGLP	RAVER1	411	Q8IY67
GAPAGPPLLFLLEAG	NTF4	51	P34130
PISLGIFPLPAGDGL	SPAG9	201	O60271
VSGAGVPGPLPDFGL	DSG2	1076	Q14126
SHGPGPLPLGALAQG	MDGA1	276	Q8NFP4
GAGFPGMLGALPLPL	MBD6	531	Q96DN6
SFGGGAGRDIPPPLI	NOTCH1	1431	P46531
GLLGPGPGPTTPLFL	LMAN2	21	Q12907
GSLRAPGPGLAQGLP	LRRC47	61	Q8N1G4
GHDLLPPGGAPAGLR	DPYS	36	Q14117
GGAGCALAGLPPLPR	FAM89B	11	Q8N5H3
LLAAGPGLPGAAGAP	BARX1	101	Q9HBU1
LPPTLFLPHFLGGDG	PNRC1	51	Q12796
LLGPEGPGLGLGVAS	FAM214B	101	Q7L5A3
AFGGPPGGLLLDALP	FOXO6	401	A8MYZ6
PGGLLLDALPGPYAA	FOXO6	406	A8MYZ6
PGPRVAPVCGLLGFG	NOTO	111	A8MTQ0
GGPRLLNGLPPGSFV	KIF7	546	Q2M1P5
PLAFRVGLSGPPGAG	MMAA	141	Q8IVH4
PNPAALFGGPGLPGL	GLIS2	356	Q9BZE0
LFGGPGLPGLPLPLA	GLIS2	361	Q9BZE0
LAKNPLLPSPFGAGG	GLIS2	411	Q9BZE0
LLPSPFGAGGLGLPV	GLIS2	416	Q9BZE0
SLLQGGGLGPLSLPP	OSTM1	61	Q86WC4
GLGLVCGLLAGLPPP	MFSD3	76	Q96ES6
ALGGPLGDLGPALGS	PATZ1	631	Q9HBE1
PGAPGGVGLSLGLLL	FZD4	11	Q9ULV1
ALAELLGAPGPAPGL	ADCY1	76	Q08828
LGPAVPLSLGAPAGG	GSC2	96	O15499
PLSLGAPAGGSGALP	GSC2	101	O15499
PLLPLLAQGPGGALG	EFNA3	16	P52797
LPGTSALGLPGSPGA	COL19A1	1096	Q14993
PPGPGGDASLLARLF	FAM20C	151	Q8IXL6
LTILRGCPGLPGAPG	FCN2	46	Q15485
PSLPLGGHLGPAGAA	CACNA1I	916	Q9P0X4
QLGAASVGPGPLGFP	C14orf93	161	Q9H972
RTFGGAPGFPLGSPL	DES	16	P17661
ALLPPLGGGLGPGSS	C2CD4D	331	B7Z1M9
LSLFGPLPGPGPALV	CYTIP	221	O60759
SLGPGAGPPPLLLGS	FAM43A	331	Q8N2R8
LLPLFSSPAGGVLGG	MAN1A1	6	P33908
LAGGPGPGDPLQLLL	INSC	111	Q1MX18
GFLPPPLPSGLFGLG	FMN2	1261	Q9NZ56
PLLFLLLLPGGSGGS	LINGO4	16	Q6UY18
AGPGSLAGQPLLGIP	PKD1	156	P98161
GPGPAGLPAFLGAEL	FOXD2	346	O60548
SGLLLLPPSGGGLPS	SYT3	196	Q9BQG1
SGPPSGGALGPRALF	SHH	291	Q15465
DGLYSSLPNGLGGPP	PSD	186	A5PKW4
LGGPPERLATLFGGP	PSD	196	A5PKW4
GPFQLLGSLGPSPGP	TSEN54	256	Q7Z6J9
GGLFASLPAPKGPAL	PRCC	36	Q92733
LPPAAFGLSFPLGGP	MSX1	246	P28360
PTAGLPTSLGGGLPY	PLEKHG4	311	Q58EX7
AAPLGPTFPGLGVSG	FOXA3	71	P55318
GSGPGLDLPLVLGLP	SHBG	291	P04278
PGAGGPLNFGPLHSL	PLAGL2	461	Q9UPG8
LPPLSPGGGAVAAAL	SMARCD2	11	Q92925
PLPFILLGGSEKGFG	RAPGEF2	396	Q9Y4G8
PLLGAHPLLLGGAGT	ZNF865	521	P0CJ78
PAAGAGLGDPPAGLL	ZNF668	446	Q96K58
LGGQFLPFPLPPAGG	ZFHX2	2341	Q9C0A1
VAGLLPGGGLLPTPN	SRSF11	131	Q05519
SGSPFLGPPFQLPLG	RAPGEF1	421	Q13905
GLLGLPGALLNYIGP	SLC23A1	171	Q9UHI7
EAPGLIPGFTPGLGA	UBQLN1	476	Q9UMX0
LLPGPPLGTGALGSP	nan	66	Q6ZRN7
SPPGFTLPPLGGSLG	TOMM40	31	O96008
NGELGFLLPSGPGPT	ZBTB9	321	Q96C00
RGLLALAPPGGLPGG	TMEM65	36	Q6PI78
VGPFLSGLAGAIPAP	PLBD2	31	Q8NHP8
GGLGPGAPLISLDPA	VSIG10L	236	Q86VR7
APLGAPGLPNGLLSG	RELA	516	Q04206
GAGEAALPLPGLLFG	TNFRSF13C	66	Q96RJ3
DPSGRPVFPIGLGGL	TBRG1	176	Q3YBR2
SPAPLLPGDLLGGGS	TNRC6B	1816	Q9UPQ9