Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	NFAT	NFATC3 NFATC4	5.65e-05	5	45	2	IPR008366
Domain	REL_2	NFATC3 NFATC4	2.52e-04	10	45	2	PS50254
Domain	RHD_dimer	NFATC3 NFATC4	2.52e-04	10	45	2	IPR032397
Domain	RHD_dimer	NFATC3 NFATC4	2.52e-04	10	45	2	PF16179
Domain	NFkB/Dor	NFATC3 NFATC4	2.52e-04	10	45	2	IPR000451
Domain	REL_1	NFATC3 NFATC4	2.52e-04	10	45	2	PS01204
Domain	RHD_DNA_bind_dom	NFATC3 NFATC4	2.52e-04	10	45	2	IPR011539
Domain	RHD_DNA_bind	NFATC3 NFATC4	2.52e-04	10	45	2	PF00554
Domain	-	NFATC3 NFATC4	2.52e-04	10	45	2	2.60.40.340
Domain	IPT	NFATC3 NFATC4	1.92e-03	27	45	2	SM00429
Domain	TIG	NFATC3 NFATC4	2.52e-03	31	45	2	PF01833
Domain	IPT	NFATC3 NFATC4	2.69e-03	32	45	2	IPR002909
Domain	p53-like_TF_DNA-bd	NFATC3 NFATC4	7.23e-03	53	45	2	IPR008967
Domain	SAM_1	ANKS6 SHANK3	1.17e-02	68	45	2	PF00536
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_CN_SIGNALING_PATHWAY	NFATC3 NFATC4	2.85e-04	12	30	2	M47956
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CALCINEURIN_SIGNALING_PATHWAY	NFATC3 NFATC4	5.16e-04	16	30	2	M47449
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAQ_PLCB_G_CALCINEURIN	NFATC3 NFATC4	5.84e-04	17	30	2	M47560
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	NFATC3 NFATC4	6.56e-04	18	30	2	M3430
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	NFATC3 NFATC4	6.56e-04	18	30	2	MM1385
Pathway	KEGG_MEDICUS_REFERENCE_BCR_PLCG_CALCINEURIN_SIGNALING_PATHWAY	NFATC3 NFATC4	6.56e-04	18	30	2	M47580
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY	NFATC3 NFATC4	7.32e-04	19	30	2	M47543
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY	NFATC3 NFATC4	8.97e-04	21	30	2	M47542
Pathway	WP_CANCER_IMMUNOTHERAPY_BY_PD1_BLOCKADE	NFATC3 NFATC4	1.08e-03	23	30	2	M39843
Pathway	BIOCARTA_GPCR_PATHWAY	NFATC3 NFATC4	1.72e-03	29	30	2	MM1495
Pathway	BIOCARTA_GPCR_PATHWAY	NFATC3 NFATC4	1.84e-03	30	30	2	M9664
Pathway	BIOCARTA_BCR_PATHWAY	NFATC3 NFATC4	2.09e-03	32	30	2	MM1355
Pathway	WP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR	NFATC3 NFATC4	2.09e-03	32	30	2	M39521
Pathway	BIOCARTA_BCR_PATHWAY	NFATC3 NFATC4	2.22e-03	33	30	2	M9494
Pathway	BIOCARTA_FMLP_PATHWAY	NFATC3 NFATC4	2.35e-03	34	30	2	M10287
Pathway	BIOCARTA_FMLP_PATHWAY	NFATC3 NFATC4	2.35e-03	34	30	2	MM1399
Pathway	BIOCARTA_FCER1_PATHWAY	NFATC3 NFATC4	3.09e-03	39	30	2	M1908
Pathway	BIOCARTA_FCER1_PATHWAY	NFATC3 NFATC4	3.09e-03	39	30	2	MM1397
Pubmed	Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli.	CRYAB NFATC3 NFATC4	4.92e-08	6	48	3	19538478
Pubmed	Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins.	NFATC3 NFATC4	1.87e-06	2	48	2	7749981
Pubmed	Genetic or pharmacologic disruption of the calcineurin-nuclear factor of activated T-cells axis prevents social stress-induced voiding dysfunction in a murine model.	NFATC3 NFATC4	1.87e-06	2	48	2	24909609
Pubmed	Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons.	NFATC3 NFATC4	1.87e-06	2	48	2	22977251
Pubmed	Role of IFN-ks, IFN-ks related genes and the DEPDC5 gene in Hepatitis B virus-related liver disease.	DEPDC5 ACP7	5.59e-06	3	48	2	25032264
Pubmed	Increased expression of NF-AT3 and NF-AT4 in the atria correlates with procollagen I carboxyl terminal peptide and TGF-β1 levels in serum of patients with atrial fibrillation.	NFATC3 NFATC4	5.59e-06	3	48	2	25422138
Pubmed	NFATc3 and NFATc4 are required for cardiac development and mitochondrial function.	NFATC3 NFATC4	5.59e-06	3	48	2	12750314
Pubmed	Developmental regulation of the mouse IGF-I exon 1 promoter region by calcineurin activation of NFAT in skeletal muscle.	NFATC3 NFATC4	1.12e-05	4	48	2	17229811
Pubmed	Alternative splicing and expression of human and mouse NFAT genes.	NFATC3 NFATC4	1.12e-05	4	48	2	18675896
Pubmed	Transcription factors of the NFAT family: regulation and function.	NFATC3 NFATC4	1.12e-05	4	48	2	9143705
Pubmed	Nuclear factor of activated T cells is activated in the endothelium of retinal microvessels in diabetic mice.	NFATC3 NFATC4	1.12e-05	4	48	2	25918731
Pubmed	HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells.	NFATC3 NFATC4	1.12e-05	4	48	2	16260021
Pubmed	Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.	NFATC3 NFATC4	1.12e-05	4	48	2	9660947
Pubmed	NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis.	NFATC3 NFATC4	1.12e-05	4	48	2	26527057
Pubmed	The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis.	NFATC3 NFATC4	1.12e-05	4	48	2	24970700
Pubmed	Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development.	NFATC3 NFATC4	1.86e-05	5	48	2	17693409
Pubmed	Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1.	NFATC3 NFATC4	1.86e-05	5	48	2	22593154
Pubmed	NFAT: ubiquitous regulator of cell differentiation and adaptation.	NFATC3 NFATC4	1.86e-05	5	48	2	11877454
Pubmed	NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy.	NFATC3 NFATC4	1.86e-05	5	48	2	20530871
Pubmed	Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif.	NFATC3 NFATC4	1.86e-05	5	48	2	7999066
Pubmed	Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.	NFATC3 NFATC4	1.86e-05	5	48	2	10089876
Pubmed	Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering.	NFATC3 NFATC4	2.79e-05	6	48	2	8814265
Pubmed	MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation.	NFATC3 NFATC4	2.79e-05	6	48	2	23543060
Pubmed	Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB.	NFATC3 NFATC4	2.79e-05	6	48	2	12788643
Pubmed	The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins.	NFATC3 NFATC4	2.79e-05	6	48	2	25728138
Pubmed	A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis.	NFATC3 NFATC4	2.79e-05	6	48	2	15339668
Pubmed	Human immunodeficiency virus type 1 Tat increases cooperation between AP-1 and NFAT transcription factors in T cells.	NFATC3 NFATC4	2.79e-05	6	48	2	16690925
Pubmed	Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells.	NFATC3 NFATC4	2.79e-05	6	48	2	24352425
Pubmed	A strategy for probing the function of noncoding RNAs finds a repressor of NFAT.	NFATC3 NFATC4	2.79e-05	6	48	2	16141075
Pubmed	Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation.	NFATC3 NFATC4	3.90e-05	7	48	2	17875713
Pubmed	NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.	NFATC3 NFATC4	3.90e-05	7	48	2	16554754
Pubmed	Extracellular HIV-Tat induces cyclooxygenase-2 in glial cells through activation of nuclear factor of activated T cells.	NFATC3 NFATC4	3.90e-05	7	48	2	18097055
Pubmed	Calcium/NFAT signalling promotes early nephrogenesis.	NFATC3 NFATC4	3.90e-05	7	48	2	21295565
Pubmed	Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts.	NFATC3 NFATC4	3.90e-05	7	48	2	17430895
Pubmed	Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth.	NFATC3 NFATC4	5.19e-05	8	48	2	12370307
Pubmed	Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity.	NFATC3 NFATC4	5.19e-05	8	48	2	7957556
Pubmed	Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling.	NFATC3 NFATC4	8.33e-05	10	48	2	19710169
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MAP3K11 DEPDC5 ANKS6 MGAT1 ATG2A PIEZO1 RASAL1 FBRS	1.24e-04	1105	48	8	35748872
Pubmed	Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation.	NFATC3 NFATC4	1.68e-04	14	48	2	19179536
Pubmed	Docking motif-guided mapping of the interactome of protein phosphatase-1.	LMTK3 HYDIN PCIF1	1.88e-04	80	48	3	19389623
Pubmed	Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.	NFATC3 NFATC4	1.94e-04	15	48	2	21047202
Pubmed	Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.	NFATC3 NFATC4	2.21e-04	16	48	2	12787506
Pubmed	TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction.	NFATC3 NFATC4	3.85e-04	21	48	2	20194497
Pubmed	Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor.	NFATC3 NFATC4	5.05e-04	24	48	2	17366632
Pubmed	Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons.	NFATC3 NFATC4	6.40e-04	27	48	2	31257105
Pubmed	A genetic approach to Mammalian glycan function.	EXT1 MGAT1	7.92e-04	30	48	2	12676797
Pubmed	Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.	NFATC3 NFATC4	1.27e-03	38	48	2	12482669
Cytoband	16q22.2	NFATC3 HYDIN	2.44e-04	22	48	2	16q22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16q22	NFATC3 HYDIN DERPC	9.44e-04	183	48	3	chr16q22
GeneFamily	Nuclear factors of activated T-cells	NFATC3 NFATC4	1.83e-05	5	25	2	665
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	LMTK3 HYDIN PCIF1	1.93e-03	181	25	3	694
GeneFamily	Proteases, serine	PRSS12 PRSS21	3.40e-03	63	25	2	738
GeneFamily	Sterile alpha motif domain containing	ANKS6 SHANK3	6.53e-03	88	25	2	760
Disease	Autistic Disorder	ABAT EXT1 NTF4 SHANK3	4.68e-04	261	41	4	C0004352
Disease	cardiovascular age measurement	EXT1 ZC3H3	7.47e-04	29	41	2	EFO_0803380
Disease	Mental Retardation, Psychosocial	AP4M1 NTF4 SHANK3	9.57e-04	139	41	3	C0025363
Disease	Profound Mental Retardation	AP4M1 NTF4 SHANK3	9.57e-04	139	41	3	C0020796
Disease	Mental deficiency	AP4M1 NTF4 SHANK3	9.57e-04	139	41	3	C0917816
Disease	joint hypermobility measurement	PRTG PIEZO1	9.68e-04	33	41	2	EFO_0007905
Disease	triglycerides to total lipids in very large VLDL percentage	MAP3K11 PCIF1	2.48e-03	53	41	2	EFO_0022340
Disease	free cholesterol to total lipids in very large VLDL percentage	MAP3K11 PCIF1	3.07e-03	59	41	2	EFO_0022289

Protein segments in the cluster

Peptide	Gene	Start	Entry
LFWSPLPPRLPTQRL	C6orf136	51	Q5SQH8
PSLPARLDRWPFSDP	CEP68	591	Q76N32
LPPRFSSPTPLWRKV	ADCK5	36	Q3MIX3
RFPIADLRPEPDPWA	ATG2A	646	Q2TAZ0
PSPLPFRLFPSVQWD	AP4M1	291	O00189
WTPPSKELLRFPPLL	NWD1	616	Q149M9
PPKGWFRLLPFPRAE	RASAL1	226	O95294
LPPFLAPEWDLLSPR	NTF4	31	P34130
PFYLRPPSFLRAPSW	CRYAB	46	P02511
RLTPFAVFPRPWSAV	ACP7	376	Q6ZNF0
SEIPAFLLPWLPSRP	DEPDC5	1306	O75140
RWAEVPPFLERSPPA	PRSS12	111	P56730
PPFLERSPPASWAQL	PRSS12	116	P56730
FLESEALPPWSPPSR	MAP9	626	Q49MG5
LFFWTRPAPGRPPSV	MGAT1	26	P26572
IDIPSFDWPIAPFPR	ABAT	236	P80404
SETWASPLFPAPRPF	LMTK3	581	Q96Q04
PRPIIFLQPPWTTVF	FCRL5	21	Q96RD9
PLRVPLDQTPLFYPW	MARCHF6	746	O60337
PPSFVEWPESLTRPR	PRTG	326	Q2VWP7
IFPRERPTPWTRAPL	DERPC	6	P0CG12
PLTFPAWVRPPEAAR	FBRS	231	Q9HAH7
GWIPPLSRFPIDIFF	HYDIN	4141	Q4G0P3
FIVFIPEWREPPTPA	PCIF1	581	Q9H4Z3
PDHFWPRFPDALRPF	EXT1	51	Q16394
PEWFPLPTPRSLHVV	CDK15	336	Q96Q40
RDLRPFPAPPTHWFL	CYP4X1	41	Q8N118
RIRFPGFEPLTPWIL	ILF2	231	Q12905
AVIPPFLPPSSFELW	ANKS6	556	Q68DC2
IPFPRFPWFRRNFPI	FDCSP	56	Q8NFU4
FPWFRRNFPIPIPES	FDCSP	61	Q8NFU4
DPRLDRWDFAPPLPS	KLHDC7A	606	Q5VTJ3
RLWPLPGTPFLPIRA	LINC02913	36	Q8NAJ2
PSNSLLTEPPFRWRF	ERVFC1	21	P60507
PAPRRAPWTLFPDSD	MAP3K11	796	Q16584
FALPLRWAPGRPLDP	FTMT	26	Q8N4E7
VRAELPLAWFGPPAP	TMEM132E	191	Q6IEE7
PAAPGPWLRRPLFSL	TGFBR3L	51	H3BV60
PIFRTSALPPLDWPL	NFATC4	396	Q14934
PTRPLSRFIPWFPYD	SHLD3	31	Q6ZNX1
RVWTSAPPPQRPFRV	CIDEB	26	Q9UHD4
WLESRRFSPIPFPPL	PRPF8	816	Q6P2Q9
LSAPPFPLSLPSWRA	ZC3H3	551	Q8IXZ2
FSPRSPAWIPVPARR	SHANK3	1161	Q9BYB0
LEWFSTLFPRIPVPV	PRPF38B	211	Q5VTL8
IFRTSSLPPLDWPLP	NFATC3	411	Q12968
PIRFWILDSHPFAPP	UEVLD	71	Q8IX04
SQPDPSWPLLFFPLL	PRSS21	291	Q9Y6M0
LFLLLLPWFPGPTRC	PIEZO1	36	Q92508
PFFWLSPLASLVIPP	TRIM4	481	Q9C037