Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-18 ERVK-7 ERVK-21 ERVK-9 ERVK-24	7.22e-07	37	92	5	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-18 ERVK-7 ERVK-21 ERVK-9 ERVK-24	8.28e-07	38	92	5	GO:0070001
GeneOntologyMolecularFunction	peptidase activity	TRHDE PCSK5 USP6 JOSD2 LMLN USP32 ERVK-18 KLK14 ERVK-7 ERVK-21 ERVK-9 ERVK-24 ATG4D	9.18e-06	654	92	13	GO:0008233
GeneOntologyMolecularFunction	endopeptidase activity	PCSK5 USP6 LMLN ERVK-18 KLK14 ERVK-7 ERVK-21 ERVK-9 ERVK-24 ATG4D	2.89e-05	430	92	10	GO:0004175
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNHD1 MYO19 DNAH2 KIF13A DYNC1I1	2.16e-04	118	92	5	GO:0003774
GeneOntologyMolecularFunction	microtubule motor activity	DNHD1 DNAH2 KIF13A DYNC1I1	3.07e-04	70	92	4	GO:0003777
GeneOntologyMolecularFunction	ATP-dependent activity	DNHD1 ABCA6 MYO19 HELZ2 DNAH2 ABCC11 MACF1 ATP6V0D2 KIF13A DYNC1I1	5.26e-04	614	92	10	GO:0140657
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	PLEKHG4B ARFGEF3 RIN3 TBC1D10A RASGRF2 ARHGEF18	6.99e-04	231	92	6	GO:0005085
GeneOntologyBiologicalProcess	microtubule-based process	TUBGCP6 DNHD1 MEGF8 INCENP CFAP73 CEP250 DNAH2 MAP3K11 MACF1 SPECC1L POLDIP2 LZTS2 KIF13A CCDC61 AGRN DYNC1I1	1.63e-05	1058	92	16	GO:0007017
Domain	Tap-RNA_bind	NXF3 NXF1	1.19e-04	4	84	2	PF09162
Domain	Tap_RNA_bd	NXF3 NXF1	1.19e-04	4	84	2	PD043466
Domain	Tap_RNA-bd	NXF3 NXF1	1.19e-04	4	84	2	IPR015245
Domain	-	MACF1 PLEC	2.96e-04	6	84	2	3.90.1290.10
Domain	Plectin_repeat	MACF1 PLEC	4.14e-04	7	84	2	IPR001101
Domain	Plectin	MACF1 PLEC	4.14e-04	7	84	2	PF00681
Domain	PLEC	MACF1 PLEC	4.14e-04	7	84	2	SM00250
Domain	Nuclear_transport_factor_2_euk	NXF3 NXF1	5.50e-04	8	84	2	IPR018222
Domain	NTF2	NXF3 NXF1	5.50e-04	8	84	2	PF02136
Domain	LAM_G_DOMAIN	NRXN3 CNTNAP1 AGRN	6.61e-04	38	84	3	PS50025
Domain	NTF2_DOMAIN	NXF3 NXF1	7.05e-04	9	84	2	PS50177
Domain	NTF2	NXF3 NXF1	7.05e-04	9	84	2	IPR002075
Domain	-	TRMT44 ZRSR2 MKRN2	7.69e-04	40	84	3	4.10.1000.10
Domain	LamG	NRXN3 CNTNAP1 AGRN	1.02e-03	44	84	3	SM00282
Domain	-	NXF3 NXF1	1.51e-03	13	84	2	3.10.450.50
Domain	Dynein_HC_stalk	DNHD1 DNAH2	1.76e-03	14	84	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH2	1.76e-03	14	84	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH2	1.76e-03	14	84	2	PF08393
Domain	MT	DNHD1 DNAH2	1.76e-03	14	84	2	PF12777
Domain	Neurexin-like	NRXN3 CNTNAP1	1.76e-03	14	84	2	IPR003585
Domain	4.1m	NRXN3 CNTNAP1	1.76e-03	14	84	2	SM00294
Domain	DHC_fam	DNHD1 DNAH2	2.02e-03	15	84	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH2	2.02e-03	15	84	2	IPR004273
Domain	NTF2-like_dom	NXF3 NXF1	2.02e-03	15	84	2	IPR032710
Domain	Dynein_heavy	DNHD1 DNAH2	2.02e-03	15	84	2	PF03028
Domain	Laminin_G	NRXN3 CNTNAP1 AGRN	2.27e-03	58	84	3	IPR001791
Domain	Znf_CCCH	TRMT44 ZRSR2 MKRN2	2.27e-03	58	84	3	IPR000571
Domain	ZF_C3H1	TRMT44 ZRSR2 MKRN2	2.27e-03	58	84	3	PS50103
Domain	DH_1	PLEKHG4B RASGRF2 ARHGEF18	2.87e-03	63	84	3	PS00741
Domain	CH	MACF1 SPECC1L PLEC	3.14e-03	65	84	3	SM00033
Domain	RhoGEF	PLEKHG4B RASGRF2 ARHGEF18	3.56e-03	68	84	3	SM00325
Domain	RhoGEF	PLEKHG4B RASGRF2 ARHGEF18	3.87e-03	70	84	3	PF00621
Domain	CH	MACF1 SPECC1L PLEC	3.87e-03	70	84	3	PF00307
Domain	DH_2	PLEKHG4B RASGRF2 ARHGEF18	3.87e-03	70	84	3	PS50010
Domain	DH-domain	PLEKHG4B RASGRF2 ARHGEF18	4.02e-03	71	84	3	IPR000219
Domain	-	PLEKHG4B RASGRF2 ARHGEF18	4.02e-03	71	84	3	1.20.900.10
Domain	-	MACF1 SPECC1L PLEC	4.02e-03	71	84	3	1.10.418.10
Domain	AAA+_ATPase	ABCA6 HELZ2 DNAH2 ABCC11	4.06e-03	144	84	4	IPR003593
Domain	AAA	ABCA6 HELZ2 DNAH2 ABCC11	4.06e-03	144	84	4	SM00382
Domain	EGF	PCSK5 NRXN3 MEGF8 CNTNAP1 AGRN	4.17e-03	235	84	5	SM00181
Domain	-	PCSK5 CNTNAP1 HECTD1	4.35e-03	73	84	3	2.60.120.260
Domain	CH	MACF1 SPECC1L PLEC	4.35e-03	73	84	3	PS50021
Domain	CH-domain	MACF1 SPECC1L PLEC	4.69e-03	75	84	3	IPR001715
Domain	Actinin_actin-bd_CS	MACF1 PLEC	4.76e-03	23	84	2	IPR001589
Domain	ACTININ_2	MACF1 PLEC	4.76e-03	23	84	2	PS00020
Domain	ACTININ_1	MACF1 PLEC	4.76e-03	23	84	2	PS00019
Domain	EGF-like_dom	PCSK5 NRXN3 MEGF8 CNTNAP1 AGRN	5.31e-03	249	84	5	IPR000742
Domain	EF-hand_5	USP32 RCN3	5.61e-03	25	84	2	PF13202
Domain	Spectrin_repeat	MACF1 PLEC	7.50e-03	29	84	2	IPR002017
Domain	Homeobox_metazoa	TLX3 TLX1 TLX2	7.78e-03	90	84	3	IPR020479
Pathway	WP_CELL_DIFFERENTIATION_INDEX	LEFTY2 TLX3 TLX1 TLX2	6.30e-05	50	61	4	M39528
Pathway	WP_CELL_DIFFERENTIATION_EXPANDED_INDEX	LEFTY2 TLX3 TLX1 TLX2	1.21e-04	59	61	4	M39723
Pubmed	A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia.	TLX3 TLX1 TLX2	1.85e-08	3	93	3	11587205
Pubmed	Development expression of Hox11 and specification of splenic cell fate.	TLX3 TLX1 TLX2	1.85e-08	3	93	3	7747804
Pubmed	The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes.	TLX3 TLX1 TLX2	7.39e-08	4	93	3	8099440
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-18 ERVK-21 ERVK-9 ERVK-24	1.42e-07	18	93	4	18664271
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-18 ERVK-7 ERVK-21	1.84e-07	5	93	3	12629516
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	STIM1 STUB1 CEP250 MKRN2 CMAS HECTD1 GCN1 NXF1	1.03e-06	285	93	8	32838362
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	INCENP PHF3 MTHFD1L HELZ2 MACF1 PLEC TRRAP HECTD1 GCN1 NXF1 SEC23A	1.42e-06	653	93	11	22586326
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-18 ERVK-7 ERVK-21 ERVK-9 ERVK-24	5.58e-06	94	93	5	21542922
Pubmed	Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3.	TLX3 TLX1 TLX2	6.60e-06	14	93	3	11581159
Pubmed	AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70.	STUB1 AQP2	7.07e-06	2	93	2	29145196
Pubmed	Characterization and developmental expression of Tlx-1, the murine homolog of HOX11.	TLX1 TLX2	7.07e-06	2	93	2	7908826
Pubmed	USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers.	USP6 USP32	7.07e-06	2	93	2	20549504
Pubmed	HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.	TLX1 TLX2	7.07e-06	2	93	2	1681546
Pubmed	Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group.	TLX3 TLX1	7.07e-06	2	93	2	18368072
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	CCHCR1 STUB1 MTHFD1L CEP250 LZTS2	7.93e-06	101	93	5	24613305
Pubmed	Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.	TLX3 TLX1	2.12e-05	3	93	2	22366949
Pubmed	Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing.	LEFTY2 PCSK5	2.12e-05	3	93	2	16141390
Pubmed	Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951.	TLX3 TLX1	2.12e-05	3	93	2	14504110
Pubmed	Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP.	STUB1 AQP2	2.12e-05	3	93	2	32164329
Pubmed	TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression.	TLX3 TLX1	2.12e-05	3	93	2	22516263
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ZRSR2 HELZ2 MACF1 POLDIP2 PLEC CMAS TRRAP GCN1 CCDC61 AGRN AARSD1 NXF1	3.18e-05	1082	93	12	38697112
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCSK5 RIN3 MEGF8 MTHFD1L NLRX1 HELZ2 MAP3K11 PLEC TRRAP HECTD1 GCN1 AGRN	3.89e-05	1105	93	12	35748872
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	MTHFD1L HELZ2 PLEC TRRAP HECTD1 GCN1 SEC23A	3.98e-05	344	93	7	30333137
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 CEP250 MACF1 PLEC KIF13A TERT	4.07e-05	234	93	6	36243803
Pubmed	CHIP Regulates Aquaporin-2 Quality Control and Body Water Homeostasis.	STUB1 AQP2	4.23e-05	4	93	2	29242247
Pubmed	The E3 ligase CHIP mediates ubiquitination and degradation of mixed-lineage kinase 3.	STUB1 MAP3K11	4.23e-05	4	93	2	24912674
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-7 ERVK-24	4.23e-05	4	93	2	10469592
Pubmed	Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability.	NXF3 NXF1	4.23e-05	4	93	2	23675524
Pubmed	Transcriptional activation by TLX1/HOX11 involves Gro/TLE corepressors.	TLX3 TLX1	4.23e-05	4	93	2	19250647
Pubmed	TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins.	TRRAP TERT	4.23e-05	4	93	2	12077335
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	MACF1 PLEC TRRAP SEC23A	5.30e-05	76	93	4	27542412
Pubmed	The Tre2 (USP6) oncogene is a hominoid-specific gene.	USP6 USP32	7.04e-05	5	93	2	12604796
Pubmed	Formation of a Tap/NXF1 homotypic complex is mediated through the amino-terminal domain of Tap and enhances interaction with nucleoporins.	NXF3 NXF1	7.04e-05	5	93	2	17978099
Pubmed	Genetic mapping of two mouse homeobox genes Tlx-1 and Tlx-2 to murine chromosomes 19 and 6.	TLX1 TLX2	7.04e-05	5	93	2	7698766
Pubmed	Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer.	RIOX1 TRRAP	7.04e-05	5	93	2	17308053
Pubmed	JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis.	STUB1 JOSD2	1.05e-04	6	93	2	23625928
Pubmed	CHIP promotes human telomerase reverse transcriptase degradation and negatively regulates telomerase activity.	STUB1 TERT	1.05e-04	6	93	2	20959453
Pubmed	The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.	LEFTY2 PCSK5	1.05e-04	6	93	2	18039650
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	PHF3 CNTNAP1 ARHGEF18 MACF1 SPECC1L DYNC1I1	1.12e-04	281	93	6	28706196
Pubmed	Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP.	STUB1 NRK	1.47e-04	7	93	2	32162334
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	CNTNAP1 SPECC1L PLEC HECTD1 GCN1	2.16e-04	202	93	5	33005030
Pubmed	Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis.	LEFTY2 DNAH2	2.52e-04	9	93	2	10330409
Pubmed	NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation.	NXF3 NXF1	2.52e-04	9	93	2	11566096
Pubmed	Proteomic profiling of Myc-associated proteins.	RIN3 NRXN3 NLRX1 TRRAP	2.55e-04	114	93	4	21150319
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	INCENP MTHFD1L MYO19 MACF1 PLEC CMAS TRRAP GCN1 AGRN AARSD1 NXF1 SEC23A	2.60e-04	1353	93	12	29467282
Pubmed	The human ATP-binding cassette (ABC) transporter superfamily.	ABCA6 ABCC11	3.14e-04	10	93	2	11435397
Pubmed	Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity.	CNTNAP1 PLEC	3.14e-04	10	93	2	19625254
Pubmed	Hox cofactors in vertebrate development.	TLX3 TLX1	3.14e-04	10	93	2	16515781
Pubmed	Molecular cloning and functional characterization of mouse Nxf family gene products.	NXF3 NXF1	3.14e-04	10	93	2	15820316
Pubmed	Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.	STUB1 MAP3K11	3.14e-04	10	93	2	28757353
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	USP6 JOSD2 MTHFD1L KLHL15 USP32 RIOX1 PLEC TRRAP HECTD1 GCN1	3.59e-04	1005	93	10	19615732
Pubmed	Evolutionary diversification of the BetaM interactome acquired through co-option of the ATP1B4 gene in placental mammals.	PHF3 RCN3	3.83e-04	11	93	2	26939788
Pubmed	Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates.	TLX3 TLX1	3.83e-04	11	93	2	15064766
Pubmed	Activator-Mediator binding regulates Mediator-cofactor interactions.	TRRAP GCN1	3.83e-04	11	93	2	20534441
Pubmed	Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.	CCHCR1 TERT	4.59e-04	12	93	2	21743467
Pubmed	Mart1 is located on mouse chromosome 19 and is excluded as a candidate for ep and ru.	PCSK5 TLX1	4.59e-04	12	93	2	9107690
Pubmed	E3 ubiquitin ligase MID1 ubiquitinates and degrades type-I interferon receptor 2.	STUB1 MKRN2	4.59e-04	12	93	2	35794827
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-21 ERVK-9	4.59e-04	12	93	2	14557543
Pubmed	USP7 controls NGN3 stability and pancreatic endocrine lineage development.	MACF1 PLEC GCN1	5.13e-04	58	93	3	37117185
Pubmed	TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.	NXF3 NXF1	6.30e-04	14	93	2	11073998
Pubmed	Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.	PHF3 TRRAP	6.30e-04	14	93	2	28263302
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	STUB1 ZRSR2 CNTNAP1 USP32 MAP3K11 MACF1 POLDIP2 PLEC CMAS HECTD1 DYNC1I1	6.40e-04	1285	93	11	35914814
Pubmed	Antigens recognized by autologous antibody in patients with renal-cell carcinoma.	ZRSR2 USP32 SPECC1L	6.54e-04	63	93	3	10508479
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP6 JOSD2 USP32 HELZ2	6.68e-04	147	93	4	29576527
Pubmed	Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons.	TLX3 TLX1	7.26e-04	15	93	2	18400903
Pubmed	Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons.	TLX3 TLX1	7.26e-04	15	93	2	32241803
Pubmed	Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons.	TLX3 TLX1	7.26e-04	15	93	2	18634777
Pubmed	USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction.	USP32 ATP6V0D2	7.26e-04	15	93	2	36476874
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	STIM1 INCENP NRK NLRX1 MAP3K11 PLEC LZTS2 CMAS TRRAP	7.48e-04	910	93	9	36736316
Pubmed	Characterization of human colon cancer antigens recognized by autologous antibodies.	STUB1 TDRD6	8.28e-04	16	93	2	9610721
Pubmed	Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.	LEFTY2 PCSK5	8.28e-04	16	93	2	20876279
Pubmed	SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity.	JOSD2 FBXW7	8.28e-04	16	93	2	29891922
Pubmed	The finished DNA sequence of human chromosome 12.	CFAP73 ERVK-21 GCN1	8.53e-04	69	93	3	16541075
Pubmed	Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1.	TLX3 TLX1	9.37e-04	17	93	2	12023301
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	STIM1 CCHCR1 STUB1 CEP250 MKRN2 POLDIP2 HECTD1 GCN1	9.48e-04	754	93	8	33060197
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	INCENP PHF3 MACF1 CMAS TRRAP HECTD1 GCN1 NXF1	9.89e-04	759	93	8	35915203
Pubmed	DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2.	STUB1 SPECC1L PLEC	1.01e-03	73	93	3	35973989
Pubmed	M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.	FBXO41 FBXW7	1.05e-03	18	93	2	15070733
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	MTHFD1L CEP250 CNTNAP1 FBXO41 MACF1 CCDC177	1.06e-03	430	93	6	32581705
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	PCSK5 CCHCR1 USP6 MEGF8 LZTS2 AGRN NXF1	1.25e-03	608	93	7	16713569
Pubmed	The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue.	STIM1 CMAS DYNC1I1	1.26e-03	79	93	3	25921334
Pubmed	Repression by PRDM13 is critical for generating precision in neuronal identity.	TLX3 TLX1	1.30e-03	20	93	2	28850031
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	TLX3 CCKBR TLX1	1.36e-03	81	93	3	22723691
Pubmed	Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.	PCSK5 NRXN3	1.44e-03	21	93	2	22959728
Pubmed	A protein interaction landscape of breast cancer.	STUB1 MYO19 MACF1 RIOX1 SPECC1L LZTS2 CMAS	1.59e-03	634	93	7	34591612
Pubmed	14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.	STUB1 FLAD1 SEC23A FBXW7	1.60e-03	186	93	4	14744259
Pubmed	HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.	HECTD1 GCN1 NXF1	1.67e-03	87	93	3	33711283
Pubmed	Renal collecting system growth and function depend upon embryonic γ1 laminin expression.	AQP2 AGRN	1.73e-03	23	93	2	21903675
Pubmed	Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.	USP6 USP32 POLDIP2	1.84e-03	90	93	3	15033168
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	USP6 USP32 MACF1 PLEC HECTD1 AGRN	1.88e-03	481	93	6	28190767
Pubmed	Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.	STUB1 MAP3K11 LZTS2	1.96e-03	92	93	3	20368287
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	STUB1 ARHGEF18 MACF1 TDRD6	1.97e-03	197	93	4	20811636
Pubmed	A human MAP kinase interactome.	CEP250 MAP3K11 MACF1 SPECC1L PLEC GCN1	1.98e-03	486	93	6	20936779
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	STIM1 MRPS30 ARFGEF3 STUB1 INCENP MTHFD1L MYO19 FLAD1 POLDIP2 CMAS SEC23A	2.16e-03	1496	93	11	32877691
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TBC1D10A PHF3 MTHFD1L HELZ2 MACF1 SPECC1L LZTS2 CMAS TRRAP AGRN NXF1	2.17e-03	1497	93	11	31527615
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	STIM1 ARFGEF3 MEGF8 PHF3 MACF1 PLEC KIF13A HECTD1	2.19e-03	861	93	8	36931259
Pubmed	Congenital Myasthenic Syndromes Overview	PLEC AGRN	2.20e-03	26	93	2	20301347
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ARFGEF3 MACF1 LZTS2 HECTD1	2.44e-03	209	93	4	36779422
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	PCSK5 MEGF8 HECTD1	2.48e-03	100	93	3	25807483
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	CEP250 LZTS2 GCN1	2.55e-03	101	93	3	26949739
Interaction	PYGO2 interactions	TLX3 TRRAP NXF1 TLX1 TLX2	1.97e-06	48	87	5	int:PYGO2
GeneFamily	EF-hand domain containing\|Plakins	MACF1 PLEC	1.99e-04	8	49	2	939
GeneFamily	NKL subclass homeoboxes and pseudogenes	TLX3 TLX1 TLX2	7.93e-04	67	49	3	519
Computational	Genes in the cancer module 95.	CCHCR1 USP6 NLRX1 STYXL2 TTC22 AQP2 TERT TLX1 TLX2	4.36e-04	560	45	9	MODULE_95
Computational	Genes in the cancer module 163.	CCHCR1 USP6 NLRX1 STYXL2 TTC22 AQP2 TERT TLX1 TLX2	4.65e-04	565	45	9	MODULE_163
Disease	nephrogenic diabetes insipidus (implicated_via_orthology)	STIM1 AQP2	3.55e-04	10	84	2	DOID:12387 (implicated_via_orthology)
Disease	gastrointestinal stromal tumor (is_implicated_in)	STIM1 TERT	4.33e-04	11	84	2	DOID:9253 (is_implicated_in)
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	TLX3 TLX1 FBXW7	4.70e-04	53	84	3	C1961099
Disease	amyotrophic lateral sclerosis, age at onset	PCSK5 NRXN3	8.21e-04	15	84	2	EFO_0004847, MONDO_0004976
Disease	Tourette syndrome, schizophrenia	PHF3 MYO19	1.19e-03	18	84	2	EFO_0004895, MONDO_0005090
Disease	response to methotrexate, neurotoxicity	STIM1 MACF1	1.33e-03	19	84	2	EFO_0011057, GO_0031427
Disease	serum albumin measurement	RIN3 TBC1D10A ABCA6 MACF1 PLEC TERT RCN3	1.51e-03	592	84	7	EFO_0004535
Disease	mean reticulocyte volume	STIM1 NLRX1 HELZ2 DNAH2 SPECC1L TRRAP TERT ATG4D	1.99e-03	799	84	8	EFO_0010701
Disease	Myasthenic Syndromes, Congenital	PLEC AGRN	2.12e-03	24	84	2	C0751882
Disease	breast cancer, lung cancer	RIN3 TERT	2.30e-03	25	84	2	MONDO_0007254, MONDO_0008903
Disease	S-warfarin to R-warfarin ratio measurement	ARFGEF3 DACT2 DYNC1I1	2.55e-03	95	84	3	EFO_0803331
Disease	Adenocarcinoma of large intestine	NRK TRRAP FBXW7	2.63e-03	96	84	3	C1319315
Disease	retinitis pigmentosa (implicated_via_orthology)	CEP250 DACT2	2.68e-03	27	84	2	DOID:10584 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RNWRLLIDQLIRNHE	TRHDE	696	Q9UKU6
SQLRHEQQRWERERQ	ARHGEF18	1061	Q6ZSZ5
WEEREVRRRQSVELH	AQP2	246	P41181
RDTRENEIWHLREQV	CCDC61	171	Q9Y6R9
TQRQWRTLEAVRHVG	DISP3	1276	Q9P2K9
DIRENRAWTVVRHDR	CNTNAP1	616	P78357
TFNWQHRILLVRARE	ERVK-18	306	O42043
TFNWQHRILLVRARE	ERVK-9	416	Q9UKH3
VRQWRAHQEEVARLE	CCDC148	371	Q8NFR7
DQVWSLLRERRADHV	ABCA6	651	Q8N139
NTNRWLRVVAHREQR	AGRN	1971	O00468
HRRLREESAEWRQFQ	SPECC1L	736	Q69YQ0
SQVLVRVDWERRFDH	AARSD1	91	Q9BTE6
LDFQRTRQEWVRLHD	CCDC144CP	751	Q8IYA2
RNVVRLWLHEAQRTF	DNHD1	2641	Q96M86
RHQAGRREVEALRLW	CFAP73	106	A6NFT4
QARVWQTRSHAARVI	CCKBR	161	P32239
VSSGRRWLREQQHRR	MTHFD1L	331	Q6UB35
VRLWDFIENRESRHV	MKRN2	376	Q9H000
ELRAWIAHTQQRHIR	RCN3	101	Q96D15
IWSRSAIVHSREREN	KIAA1107	836	Q9UPP5
NLDSDVVQLRERHWR	POLDIP2	271	Q9Y2S7
HTDQVVQRRARCWDI	NXF3	11	Q9H4D5
SLRQAVITVRQHRWV	DUSP13	151	Q6B8I1
RIRQRWKEASHRNQL	LIN37	216	Q96GY3
RQRHWQREREALRED	LZTS2	361	Q9BRK4
RRLRWLQQEEEERRH	INCENP	646	Q9NQS7
HNLRRWEATQQVLRV	KLK14	96	Q9P0G3
RHREQERQWRAVMLI	MYO19	776	Q96H55
RLWDVRDNKIVRHTV	LMLN	326	Q96KR4
LRRRHWVALRQVDGV	JOSD2	121	Q8TAC2
VLWDNRSHRRTPVQR	DYNC1I1	366	O14576
LTWRDVQHVIVRTSR	PCSK5	406	Q92824
WHDRDRIHVTVRRDR	NXF1	86	Q9UBU9
QRLHRLWEEEVSRRG	ABCC11	131	Q96J66
LNDNEWHTVRVVRRG	NRXN3	771	Q9Y4C0
RWVAHQEKETRRLQR	MEGF8	771	Q7Z7M0
AARREQKALWRIQRH	TUBGCP6	771	Q96RT7
EERHRPVRDWILRQR	MSLN	561	Q13421
AVLLSRTWHVRRQAQ	GCN1	571	Q92616
RTWHVRRQAQQTVRK	GCN1	576	Q92616
TEAIQRHRRNLAEWF	NLRX1	76	Q86UT6
LNSWDRARVQRHLEL	NLRX1	921	Q86UT6
SRWERATEVTVARQR	MACF1	4556	Q9UPN3
VWLQNRREATVERTR	HECTD1	2096	Q9ULT8
RHDRRRWRHTDTIIQ	KLHL15	206	Q96M94
VARRKHRRWQSTVEI	DACT2	601	Q5SW24
TFNWQHRILLVRARE	ERVK-24	306	P61566
TFNWQHRILLVRARE	ERVK-7	306	P61567
RWNSIEERRIHQESE	STUB1	146	Q9UNE7
CHVTDIRVRQAVREW	ARFGEF3	2151	Q5TH69
QAALRQTEAREIEWR	CEP250	2156	Q9BV73
IRQHRIDTNWRRGEL	FBXW7	356	Q969H0
LELSRAQEARRRWQQ	CCHCR1	406	Q8TD31
TFNWQHRILLVRARE	ERVK-21	416	P61565
AQARVTVEWLRVRDD	LEFTY2	141	O00292
AIQNWQRRPRRHSTE	FBXO41	466	Q8TF61
WELQRVHAKQRRERE	CCDC177	366	Q9NQR7
TVASELRHRQWVERT	ERMARD	551	Q5T6L9
LRHRQWVERTLRSRQ	ERMARD	556	Q5T6L9
ELQEWVRRTQAVELR	HELZ2	111	Q9BYK8
QRQEQRSRLSRIWLE	FLAD1	11	Q8NFF5
QQLQEELRWRRTFLH	BTN2A2	311	Q8WVV5
QHDRREAIRQTWGRE	B3GNT7	146	Q8NFL0
LRNPALRERHWDQVR	DNAH2	1306	Q9P225
LRERHWDQVRDEIQR	DNAH2	1311	Q9P225
EQLRRREHLLAQWEL	MAP3K11	436	Q16584
VEVQDSIHRWERRRT	RIN3	851	Q8TB24
RTLHDRWNEVTRRIE	KIF13A	976	Q9H1H9
RRQRRWEDIFNQHEE	NRK	726	Q7Z2Y5
RRIERWQATVHAAES	MRPS30	61	Q9NP92
QVVNGRVHIRDWREE	TRMT44	681	Q8IYL2
WHRCRVVSRQAQESR	TDRD6	81	O60522
SVVRRHQFRWSEIQK	CMAS	171	Q8NFW8
RRTATNRVLNVLRHW	RASGRF2	911	O14827
AALRERLHRWQQIEI	STIM1	421	Q13586
RLWEREAVLVRRQDH	RIOX1	221	Q9H6W3
QRRIRVTTIARNWAD	SEC23A	491	Q15436
VHAWRERLSREQVRQ	CHST7	431	Q9NS84
LEQERRHRQIVSWFA	ATG4D	206	Q86TL0
RRLQRHAEERQATSW	TEX13D	91	A0A0J9YY54
RHLAEERLEQLRRWH	ZFR2	526	Q9UPR6
REANWRQTRRVATLV	MPV17L	41	Q2QL34
NIRWIREAARHRLVV	UROC1	491	Q96N76
VVQVRTRSLLWTREH	PLEKHG4B	216	Q96PX9
AIIAAWRRRQEETRT	STYXL2	1136	Q5VZP5
KELAAWRRRENRHTI	PHF3	1021	Q92576
QQRHGERDVEVERWR	PLEC	1301	Q15149
WRRQTAEEREAERQQ	TLX3	221	O43711
WRRQTAEEREAERQQ	TLX1	256	P31314
IEREHLIQLRRWQET	TBC1D10A	361	Q9BXI6
ARLRQELQRVWRGHT	TTC22	511	Q5TAA0
QLRRVWVSENFQERH	TRRAP	1666	Q9Y4A5
RERQRLHEEWLLREQ	ZRSR2	66	Q15696
IHRAWRTFVLRVRAQ	TERT	686	O14746
WDNHLRRNRSIIVDL	USP6	666	P35125
EAWDNHLRRNRSIVV	USP32	866	Q8NFA0
KWRRQTAEEREAERH	TLX2	211	O43763
RNIVWIAECISQRHR	ATP6V0D2	326	Q8N8Y2