Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	PDZ domain binding	LIN7B GRIP1 KCNJ12 DLG4 KCNJ18 LIN7A	1.33e-05	123	84	6	GO:0030165
GeneOntologyMolecularFunction	L27 domain binding	LIN7B LIN7A	1.04e-04	4	84	2	GO:0097016
GeneOntologyCellularComponent	transport vesicle	LIN7B PCSK2 SPRED2 DLG4 FGFR4 SLC35F1 GNAS SLC2A3 DYNC1I1 LIN7A	3.16e-05	519	81	10	GO:0030133
GeneOntologyCellularComponent	MPP7-DLG1-LIN7 complex	LIN7B LIN7A	1.47e-04	5	81	2	GO:0097025
GeneOntologyCellularComponent	specific granule	ILF2 CD33 ATP11A ITGAL SLC2A3	3.96e-04	160	81	5	GO:0042581
GeneOntologyCellularComponent	specific granule membrane	CD33 ATP11A ITGAL SLC2A3	4.33e-04	91	81	4	GO:0035579
GeneOntologyCellularComponent	sarcolemma	SYNM KCNJ12 GNAS KCNJ18 ALOX5	8.62e-04	190	81	5	GO:0042383
GeneOntologyCellularComponent	collagen-containing extracellular matrix	COL4A6 EYS COL11A1 DSPP CFDP1 BMPER FGG PLXNB2	1.03e-03	530	81	8	GO:0062023
MousePheno	enlarged stomach	SPRED2 ANKRD20A4P ANKRD20A3P ANKRD20A1	1.67e-05	33	66	4	MP:0003883
Domain	K_chnl_inward-rec_Kir2.2	KCNJ12 KCNJ18	1.95e-05	2	83	2	IPR003272
Domain	K_chnl_inward-rec_Kir_N	KCNJ12 KCNJ18	5.84e-05	3	83	2	IPR013673
Domain	IRK_N	KCNJ12 KCNJ18	5.84e-05	3	83	2	PF08466
Domain	PrprotnconvertsP	PCSK2 PCSK7	4.04e-04	7	83	2	IPR002884
Domain	P_proprotein	PCSK2 PCSK7	4.04e-04	7	83	2	PF01483
Domain	S8_pro-domain	PCSK2 PCSK7	4.04e-04	7	83	2	IPR032815
Domain	-	PCSK2 PCSK7	4.04e-04	7	83	2	3.30.70.850
Domain	S8_pro-domain	PCSK2 PCSK7	4.04e-04	7	83	2	PF16470
Domain	PDZ	LIN7B GRIP1 DLG4 PDZD7 LIN7A	4.13e-04	141	83	5	PF00595
Domain	PDZ	LIN7B GRIP1 DLG4 PDZD7 LIN7A	5.16e-04	148	83	5	SM00228
Domain	-	LIN7B GRIP1 DLG4 PDZD7 LIN7A	5.48e-04	150	83	5	2.30.42.10
Domain	PDZ	LIN7B GRIP1 DLG4 PDZD7 LIN7A	5.65e-04	151	83	5	PS50106
Domain	PDZ	LIN7B GRIP1 DLG4 PDZD7 LIN7A	5.82e-04	152	83	5	IPR001478
Domain	Peptidase_S8_His-AS	PCSK2 PCSK7	6.88e-04	9	83	2	IPR022398
Domain	Peptidase_S8_Ser-AS	PCSK2 PCSK7	6.88e-04	9	83	2	IPR023828
Domain	Peptidase_S8_subtilisin-rel	PCSK2 PCSK7	8.58e-04	10	83	2	IPR015500
Domain	L27_C	LIN7B LIN7A	8.58e-04	10	83	2	IPR014775
Domain	L27	LIN7B LIN7A	8.58e-04	10	83	2	PF02828
Domain	SUBTILASE_ASP	PCSK2 PCSK7	8.58e-04	10	83	2	PS00136
Domain	SUBTILASE_HIS	PCSK2 PCSK7	8.58e-04	10	83	2	PS00137
Domain	SUBTILASE_SER	PCSK2 PCSK7	8.58e-04	10	83	2	PS00138
Domain	-	PCSK2 PCSK7	1.05e-03	11	83	2	3.40.50.200
Domain	Peptidase_S8/S53_dom	PCSK2 PCSK7	1.05e-03	11	83	2	IPR000209
Domain	Peptidase_S8	PCSK2 PCSK7	1.05e-03	11	83	2	PF00082
Domain	WWE	DDHD2 PARP12	1.25e-03	12	83	2	PS50918
Domain	WWE	DDHD2 PARP12	1.25e-03	12	83	2	PF02825
Domain	WWE-dom	DDHD2 PARP12	1.25e-03	12	83	2	IPR004170
Domain	L27	LIN7B LIN7A	1.47e-03	13	83	2	SM00569
Domain	L27	LIN7B LIN7A	1.47e-03	13	83	2	PS51022
Domain	L27_dom	LIN7B LIN7A	1.47e-03	13	83	2	IPR004172
Domain	K_chnl_inward-rec_Kir_cyto	KCNJ12 KCNJ18	2.25e-03	16	83	2	IPR013518
Domain	IRK	KCNJ12 KCNJ18	2.25e-03	16	83	2	PF01007
Domain	-	KCNJ12 KCNJ18	2.25e-03	16	83	2	2.60.40.1400
Domain	K_chnl_inward-rec_Kir	KCNJ12 KCNJ18	2.25e-03	16	83	2	IPR016449
Domain	Propept_inh	PCSK2 PCSK7	2.54e-03	17	83	2	IPR009020
Domain	PP2C	PP2D1 PPM1A	2.54e-03	17	83	2	IPR015655
Domain	PP2C	PP2D1 PPM1A	3.18e-03	19	83	2	PF00481
Domain	PP2Cc	PP2D1 PPM1A	3.52e-03	20	83	2	SM00332
Domain	PPM-type_phosphatase_dom	PP2D1 PPM1A	3.52e-03	20	83	2	IPR001932
Domain	-	PP2D1 PPM1A	3.52e-03	20	83	2	3.60.40.10
Domain	PPM_2	PP2D1 PPM1A	3.52e-03	20	83	2	PS51746
Domain	G_patch	PINX1 RBM17	4.65e-03	23	83	2	SM00443
Domain	G_patch_dom	PINX1 RBM17	4.65e-03	23	83	2	IPR000467
Domain	G_PATCH	PINX1 RBM17	4.65e-03	23	83	2	PS50174
Domain	G-patch	PINX1 RBM17	4.65e-03	23	83	2	PF01585
Domain	Collagen	COL4A6 COL11A1 GLDN	6.43e-03	85	83	3	IPR008160
Domain	Collagen	COL4A6 COL11A1 GLDN	6.43e-03	85	83	3	PF01391
Pubmed	A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.	LIN7B KCNJ12 DLG4 KCNJ18 LIN7A	1.93e-11	10	85	5	14960569
Pubmed	Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.	LIN7B KCNJ12 DLG4 LIN7A	1.25e-07	19	85	4	15024025
Pubmed	Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex.	LIN7B DLG4 LIN7A	1.40e-07	5	85	3	10341223
Pubmed	Expression of testicular germ cell genes identified by differential display analysis.	ANKRD20A4P ANKRD20A3P ANKRD20A1	7.82e-07	8	85	3	12634303
Pubmed	C-terminal interactors of the AMPA receptor auxiliary subunit Shisa9.	LIN7B GRIP1 DLG4	1.17e-06	9	85	3	24498314
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	ILF2 SYNM DHX38 PARG CFDP1 PINX1 OLA1 ITGAL SLC3A2 RBM17	4.49e-06	653	85	10	33742100
Pubmed	Expression of pituitary tumour-derived, N-terminally truncated isoform of fibroblast growth factor receptor 4 (ptd-FGFR4) correlates with tumour invasiveness but not with G-protein alpha subunit (gsp) mutation in human GH-secreting pituitary adenomas.	FGFR4 GNAS	5.90e-06	2	85	2	18070145
Pubmed	Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse.	KCNJ12 KCNJ18	5.90e-06	2	85	2	15705530
Pubmed	Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR.	ILF2 EIF2AK2	1.77e-05	3	85	2	10320367
Pubmed	Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.	PCSK2 PCSK7	1.77e-05	3	85	2	22396549
Pubmed	Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense.	ILF2 EIF2AK2	1.77e-05	3	85	2	21123651
Pubmed	Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study.	PCSK2 PCSK7	1.77e-05	3	85	2	12358783
Pubmed	Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse.	PTCHD1 DLG4	1.77e-05	3	85	2	28416808
Pubmed	Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels.	KCNJ12 KCNJ18	1.77e-05	3	85	2	17640933
Pubmed	Expression of cadherin 23 isoforms is not conserved: implications for a mouse model of Usher syndrome type 1D.	CDH23 DLG4	1.77e-05	3	85	2	19756182
Pubmed	Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.	KCNJ12 KCNJ18	1.77e-05	3	85	2	8083233
Pubmed	The consequences of disrupting cardiac inwardly rectifying K(+) current (I(K1)) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes.	KCNJ12 KCNJ18	1.77e-05	3	85	2	11410627
Pubmed	Morphology, GluR1 and GRIP-C localization differ in octopus cells of C57BL6 and B6Cast mice.	GRIP1 CDH23	1.77e-05	3	85	2	12204345
Pubmed	Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs.	CDHR1 CDH23	1.77e-05	3	85	2	11597768
Pubmed	Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation.	KCNJ12 KCNJ18	1.77e-05	3	85	2	10904001
Pubmed	Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase.	ILF2 EIF2AK2	1.77e-05	3	85	2	11438540
Pubmed	Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members.	CDHR1 CDH23	1.77e-05	3	85	2	20498078
Pubmed	Assignment of the murine inward rectifier potassium channel Irk2 (Kir2.2) gene to the central region of mouse chromosome 11.	KCNJ12 KCNJ18	3.53e-05	4	85	2	8921409
Pubmed	MALS is a binding partner of IRSp53 at cell-cell contacts.	LIN7B LIN7A	3.53e-05	4	85	2	14596909
Pubmed	Functional characterization of inward rectifier potassium ion channel in murine fetal ventricular cardiomyocytes.	KCNJ12 KCNJ18	3.53e-05	4	85	2	20798526
Pubmed	A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction.	KCNJ12 KCNJ18	3.53e-05	4	85	2	32990585
Pubmed	Ggamma13 interacts with PDZ domain-containing proteins.	LIN7B DLG4	3.53e-05	4	85	2	16473877
Pubmed	Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities in mice.	PTCHD1 CDH23	3.53e-05	4	85	2	38492568
Pubmed	Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice.	LIN7B LIN7A	3.53e-05	4	85	2	17923534
Pubmed	Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function.	DLG4 GNAS	3.53e-05	4	85	2	27759003
Pubmed	Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder.	LIN7B LIN7A	3.53e-05	4	85	2	18286632
Pubmed	Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.	LIN7B DLG4 LIN7A	5.45e-05	30	85	3	16186258
Pubmed	Cellular Functions of the Autism Risk Factor PTCHD1 in Mice.	PTCHD1 DLG4	5.87e-05	5	85	2	29118110
Pubmed	PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current.	LIN7B DLG4	5.87e-05	5	85	2	15317815
Pubmed	Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.	KCNJ12 KCNJ18	5.87e-05	5	85	2	16177047
Pubmed	The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions.	LIN7B LIN7A	5.87e-05	5	85	2	17237226
Pubmed	Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice.	LIN7B LIN7A	5.87e-05	5	85	2	11104771
Pubmed	The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins.	DLG4 LIN7A	8.80e-05	6	85	2	9482110
Pubmed	Genetic mapping refines DFNB3 to 17p11.2, suggests multiple alleles of DFNB3, and supports homology to the mouse model shaker-2.	KCNJ12 KCNJ18	8.80e-05	6	85	2	9529344
Pubmed	Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.	PCSK2 PCSK7	8.80e-05	6	85	2	8940009
Pubmed	The inward rectifier potassium channel family.	KCNJ12 KCNJ18	8.80e-05	6	85	2	7580148
Pubmed	Ferric Chelate Reductase 1 Like Protein (FRRS1L) Associates with Dynein Vesicles and Regulates Glutamatergic Synaptic Transmission.	DLG4 DYNC1I1	8.80e-05	6	85	2	29276473
Pubmed	A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins.	LIN7B LIN7A	8.80e-05	6	85	2	15863617
Pubmed	Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP.	GRIP1 DLG4	8.80e-05	6	85	2	12597860
Pubmed	Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.	DLG4 PDZD7 LIN7A	9.49e-05	36	85	3	26053890
Pubmed	A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.	LIN7B LIN7A	1.23e-04	7	85	2	9753324
Pubmed	Proteolytic processing in the secretory pathway.	PCSK2 PCSK7	1.23e-04	7	85	2	10409610
Pubmed	The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.	PCSK2 PCSK7	1.23e-04	7	85	2	7819324
Pubmed	Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.	GRIP1 DLG4	1.23e-04	7	85	2	17093100
Pubmed	Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells.	GRIP1 DLG4	1.23e-04	7	85	2	15207857
Pubmed	Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity.	GRIP1 DLG4	1.23e-04	7	85	2	20573893
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	COL11A1 ILF2 WDR6 PINX1 FBXO11 GNAS OLA1 EIF2AK2 CDC42BPB SBSN PARP12 RBM17	1.24e-04	1371	85	12	36244648
Pubmed	The pro-alpha2(XI) collagen gene is expressed in odontoblasts.	COL11A1 DSPP	1.64e-04	8	85	2	20059976
Pubmed	Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.	PCSK2 PCSK7	1.64e-04	8	85	2	9885250
Pubmed	Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.	PCSK2 PCSK7	1.64e-04	8	85	2	10037747
Pubmed	Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS.	KCNJ12 KCNJ18	1.64e-04	8	85	2	27930290
Pubmed	The activation and physiological functions of the proprotein convertases.	PCSK2 PCSK7	2.10e-04	9	85	2	18343183
Pubmed	The prohormone theory and the proprotein convertases: it is all about serendipity.	PCSK2 PCSK7	2.10e-04	9	85	2	21805236
Pubmed	The proprotein convertases, 20 years later.	PCSK2 PCSK7	2.10e-04	9	85	2	21805237
Pubmed	The biology and therapeutic targeting of the proprotein convertases.	PCSK2 PCSK7	2.10e-04	9	85	2	22679642
Pubmed	The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.	PCSK2 PCSK7	2.10e-04	9	85	2	23775089
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	GRIP1 ILF2 DHX38 GLOD4 OLA1 EIF2AK2 CDC42BPB	2.23e-04	498	85	7	36634849
Pubmed	Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly.	CDHR1 BMPER LIN7A	2.39e-04	49	85	3	21795542
Pubmed	Massively parallel DNA sequencing facilitates diagnosis of patients with Usher syndrome type 1.	CDH23 PDZD7	2.62e-04	10	85	2	24618850
Pubmed	Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.	PCSK2 PCSK7	2.62e-04	10	85	2	16163737
Pubmed	Role of beta-catenin in synaptic vesicle localization and presynaptic assembly.	DLG4 LIN7A	2.62e-04	10	85	2	14622577
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	COL4A6 FGFR4 FGG GNAS HSPA1L PPM1A	3.05e-04	371	85	6	25241761
Pubmed	FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.	FBXO11 HSPA1L	3.20e-04	11	85	2	37279268
Pubmed	An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation.	CDC42BPB CEP170B	3.83e-04	12	85	2	11867214
Pubmed	Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport.	LIN7B LIN7A	3.83e-04	12	85	2	10846156
Pubmed	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.	ILF2 PFKFB2 PPM1A SLC3A2 RBM17	4.22e-04	256	85	5	32698014
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	ILF2 DHX38 PFKFB2 SBSN PPM1A SLC3A2 RBM17	4.42e-04	558	85	7	27591049
Pubmed	A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2).	KCNJ12 KCNJ18	4.52e-04	13	85	2	10049592
Pubmed	Mechanochemical control of epidermal stem cell divisions by B-plexins.	GNAS PLXNB2	4.52e-04	13	85	2	33637728
Pubmed	Genome-wide and candidate gene association study of cigarette smoking behaviors.	ZNF138 SETD7	4.52e-04	13	85	2	19247474
Pubmed	MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.	GNAS OLA1 ITGAL PLXNB2 SLC2A3 SLC3A2 LIN7A	4.76e-04	565	85	7	20458337
Pubmed	Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.	CDH23 DLG4 GNAS	5.03e-04	63	85	3	17672918
Pubmed	Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.	FGFR4 EIF2AK2	5.27e-04	14	85	2	11350938
Pubmed	Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.	TCF20 CEP170B	5.27e-04	14	85	2	9179496
Pubmed	PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway.	CDC42BPB PPM1A	5.27e-04	14	85	2	18586681
Pubmed	The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.	GNAS EIF2AK2	5.27e-04	14	85	2	9151674
Pubmed	FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress.	FBXO31 FBXO11	5.27e-04	14	85	2	23319600
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	TCF20 DSPP CDH23 HSPA1L	5.39e-04	152	85	4	34299191
Pubmed	Defining the membrane proteome of NK cells.	ILF2 ALDH16A1 DHX38 ACBD5 ATP11A GNAS OLA1 ITGAL EIF2AK2 SLC3A2	5.61e-04	1168	85	10	19946888
Pubmed	Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.	GRIP1 PCSK2 DLG4	6.03e-04	67	85	3	16987237
Pubmed	Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.	DLG4 LIN7A	6.07e-04	15	85	2	23782696
Pubmed	Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity.	GRIP1 DLG4	6.07e-04	15	85	2	26880306
Pubmed	Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.	DLG4 DYNC1I1	6.93e-04	16	85	2	21920314
Pubmed	Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.	PCSK2 PCSK7	6.93e-04	16	85	2	20876279
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	USP31 DPP6 ILF2 DLG4 FGG OLA1 CDC42BPB CEP170B SLC2A3 DYNC1I1 SLC3A2	7.20e-04	1431	85	11	37142655
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	COL4A6 BMPER FGG PLXNB2	7.67e-04	167	85	4	22159717
Pubmed	MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex.	LIN7B LIN7A	7.84e-04	17	85	2	18403412
Pubmed	Identification of PSD-95 palmitoylating enzymes.	DLG4 GNAS	7.84e-04	17	85	2	15603741
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	GRIP1 DOCK11 R3HDM2 PFKFB2 TSPYL1 CEP170B	8.01e-04	446	85	6	24255178
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	DSPP DLG4 GNAS DYNC1I1	8.38e-04	171	85	4	20201926
Pubmed	Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation.	GRIP1 DLG4	8.80e-04	18	85	2	18311135
Pubmed	Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice.	GRIP1 DLG4	8.80e-04	18	85	2	34455539
Pubmed	PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis.	KCNJ12 KCNJ18	8.80e-04	18	85	2	21511879
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	COL4A6 COL11A1 FGG PLXNB2	9.13e-04	175	85	4	28071719
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	USP31 ILF2 SYNM WDR6 ACBD5 GNAS DDHD2 PLXNB2 HSPA1L CDC42BPB SLC3A2	9.84e-04	1487	85	11	33957083
Interaction	ANKRD20A4P interactions	ANKRD20A4P ANKRD20A2P ANKRD20A1	1.34e-06	6	83	3	int:ANKRD20A4P
Interaction	ANKRD20A2P interactions	ANKRD20A4P ANKRD20A2P ANKRD20A1	2.33e-06	7	83	3	int:ANKRD20A2P
Interaction	KCNJ12 interactions	LIN7B KCNJ12 DLG4 LIN7A	5.08e-06	28	83	4	int:KCNJ12
Interaction	ANKRD20A1 interactions	ANKRD20A4P ANKRD20A2P ANKRD20A1	1.09e-05	11	83	3	int:ANKRD20A1
Interaction	GRM3 interactions	GRIP1 DLG4 PPM1A	5.26e-05	18	83	3	int:GRM3
Cytoband	4q28	SETD7 FGG	1.21e-04	9	85	2	4q28
GeneFamily	PDZ domain containing	LIN7B GRIP1 DLG4 PDZD7 LIN7A	1.37e-04	152	59	5	1220
GeneFamily	Proprotein convertase subtilisin/kexin family	PCSK2 PCSK7	3.71e-04	9	59	2	973
GeneFamily	PDZ domain containing\|Crumbs complex	LIN7B LIN7A	3.71e-04	9	59	2	1223
GeneFamily	Potassium voltage-gated channel subfamily J	KCNJ12 KCNJ18	1.22e-03	16	59	2	276
GeneFamily	Cadherin related	CDHR1 CDH23	1.38e-03	17	59	2	24
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	PINX1 RBM17	2.32e-03	22	59	2	579
GeneFamily	Actins\|Deafness associated genes	DSPP CDH23 PDZD7	5.99e-03	113	59	3	1152
GeneFamily	Cyclins\|F-boxes other	FBXO31 FBXO11	7.18e-03	39	59	2	560
GeneFamily	Ankyrin repeat domain containing	ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A1	8.01e-03	242	59	4	403
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	TNFSF8 CD33 SIRPB1 FGFR4 ITGAL	9.15e-03	394	59	5	471
GeneFamily	Collagens	COL4A6 COL11A1	9.88e-03	46	59	2	490
Coexpression	NABA_CORE_MATRISOME	COL4A6 MFAP3 EYS COL11A1 GLDN DSPP BMPER FGG	3.17e-06	275	85	8	M5884
Coexpression	NABA_CORE_MATRISOME	COL4A6 MFAP3 COL11A1 GLDN DSPP BMPER FGG	2.83e-05	270	85	7	MM17057
Coexpression	DESCARTES_ORGANOGENESIS_SENSORY_NEURONS	SYNM CDHR1 KCNJ12 RAP1GAP2 KCNJ18	3.85e-05	116	85	5	MM3649
Coexpression	NABA_ECM_GLYCOPROTEINS	MFAP3 EYS GLDN DSPP BMPER FGG	4.34e-05	196	85	6	M3008
Coexpression	GSE20152_SPHK1_KO_VS_WT_HTNFA_OVERXPRESS_ANKLE_UP	FBXO11 DLG4 TSPYL1 CEP170B SLC3A2 HMG20B	4.59e-05	198	85	6	M7684
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|lung / Disease (COVID-19 only), tissue and cell type	DOCK11 CD33 RAP1GAP2 ITGAL ALOX5 SLC2A3	2.14e-06	197	85	6	a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK11 CD33 RAP1GAP2 ITGAL ALOX5 SLC2A3	2.21e-06	198	85	6	ea34096bee852a7e996f097fa279381afa8f86ff
ToppCell	mLN-(5)_Dendritic_cell-(53)_Lymphoid_DC\|mLN / shred on region, Cell_type, and subtype	HMSD SPRED2 ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A1	2.21e-06	198	85	6	da84c76afe835aeee39da04b63c03549218b5d91
ToppCell	mLN-Dendritic_cell-Lymphoid_DC\|mLN / Region, Cell class and subclass	HMSD SPRED2 ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A1	2.21e-06	198	85	6	3965a9f1e8a51a196e5349aaca5fa5ed1cd8ee92
ToppCell	Parenchyma_Control_(B.)\|World / Sample group, Lineage and Cell type	GLDN DOCK11 R3HDM2 GNAS CDC42BPB ALOX5	2.34e-06	200	85	6	220b6e5f936b3d08b031d6cabc5793213b98b8e2
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-neutrophil\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD33 RAP1GAP2 PDZD7 ALOX5 SLC2A3	1.02e-05	150	85	5	6e806a028c0519489151c181d9907e05289e27e0
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Myeloid-neutrophil\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD33 RAP1GAP2 CDH23 ALOX5 SLC2A3	1.62e-05	165	85	5	4fe7c3c9370a556cf4e308a2e723b4b907a6cc25
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBM12B RAP1GAP2 FPGT ITGAL ALOX5	2.03e-05	173	85	5	c31076c725f4cd912c56903592a2d9356ae59f54
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBM12B RAP1GAP2 FPGT ITGAL ALOX5	2.03e-05	173	85	5	a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-ACTC+_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	PTCHD1 ANKRD20A4P SYNM ANKRD20A3P ANKRD20A1	2.73e-05	184	85	5	39168ca2bbf1369c9fe87c67f0aaff5e3cd03151
ToppCell	Control-Myeloid-Macrophage_Alveolar\|World / Disease state, Lineage and Cell class	GLDN DOCK11 MCF2L2 CDC42BPB ALOX5	2.80e-05	185	85	5	85cb81759589a26d83676cffbf2bc37399683c10
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	LIN7B SLC9A5 RAP1GAP2 DLG4 DYNC1I1	2.87e-05	186	85	5	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	Control-Myeloid-Macrophage_Alveolar\|Control / Disease state, Lineage and Cell class	GLDN DOCK11 MCF2L2 CDC42BPB ALOX5	3.10e-05	189	85	5	937e876122bc4b94372a4104e9c1a9068c232018
ToppCell	IPF-Myeloid-Macrophage_Alveolar\|IPF / Disease state, Lineage and Cell class	GLDN DOCK11 MCF2L2 CDC42BPB ALOX5	3.18e-05	190	85	5	e539ebc0f4c5ee5dba86c614387be7d91338ad47
ToppCell	IPF-Myeloid-Macrophage_Alveolar\|Myeloid / Disease state, Lineage and Cell class	GLDN DOCK11 MCF2L2 CDC42BPB ALOX5	3.18e-05	190	85	5	2592765016f291565697265800a232b2edef3792
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DLG4 TSPYL1 CEP170B SLC2A3 DYNC1I1	3.51e-05	194	85	5	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM2\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	GLDN CD33 BEX4 CDC42BPB ALOX5	3.78e-05	197	85	5	d8ef5cb88dd66e112cb94217b9ad5cd70164f1d0
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GLDN CD33 BEX4 CDC42BPB ALOX5	3.78e-05	197	85	5	33f2fe101ae5744eea3915add37e60aa398bb97f
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM2-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GLDN CD33 BEX4 CDC42BPB ALOX5	3.78e-05	197	85	5	5e9a3932ae5147a3d73dc70f1545926a692930ed
ToppCell	Severe_COVID-19-Myeloid-TRAM2\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	GLDN CD33 BEX4 CDC42BPB ALOX5	3.78e-05	197	85	5	8a126cfe1529f3d75a806aa492743314a8a43ef9
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM2-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GLDN CD33 BEX4 CDC42BPB ALOX5	3.78e-05	197	85	5	9262785807faeb32417fad7ef202405053e453e2
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ATP11A PFKFB2 ALOX5 SLC2A3 LIN7A	3.96e-05	199	85	5	b7af2b4fe6866cc8c78cf0f78390aab1b1b389ba
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CD33 RAP1GAP2 CDH23 ITGAL ALOX5	3.96e-05	199	85	5	ac866ae110967c5867ff4601939b79861d43df54
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GLDN DOCK11 CD33 SIRPB1 ALOX5	4.06e-05	200	85	5	efdbd1273b07d9fe957380e347b5b6b45db0a271
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GLDN DOCK11 CD33 SIRPB1 ALOX5	4.06e-05	200	85	5	9ca86928fceaa1fefd0f9ffcfa5cc0a210ee5792
ToppCell	control-HLA-DR-_S100A+_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CD33 ATP11A SIRPB1 PLXNB2 ALOX5	4.06e-05	200	85	5	9e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCell	(53)_Lymphoid_DC\|World / shred on Cell_type and subtype	HMSD SPRED2 ANKRD20A2P ANKRD20A3P ANKRD20A1	4.89e-05	208	85	5	30212cfacad94a7cc562a69efa73a31259851515
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPP6 COL11A1 COQ6 ZNF687	1.06e-04	128	85	4	2cf0384240a4a663869cf6b27d954236f6214a9a
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CD33 RAP1GAP2 ALOX5 SLC2A3	1.71e-04	145	85	4	ab0e254a8d01021619853a6c175f620ccef217d8
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Neutrophil\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CD33 RAP1GAP2 ALOX5 SLC2A3	1.71e-04	145	85	4	2beb4ea3838796c580076ab7769de877a3a0552c
ToppCell	droplet-Kidney-nan-24m-Lymphocytic-CD45____macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTCHD1 RAP1GAP2 ITGAL SLC2A3	1.95e-04	150	85	4	34774b015adecc2be56a471fda8994e89a6ad93e
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related-Oligodendrocyte/OPC\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	PTCHD1 CDHR1 ALDH16A1 PARP12	2.00e-04	151	85	4	4533bccc996395f74b16af939ce79b6fe253c073
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	PTCHD1 CDHR1 ALDH16A1 PARP12	2.00e-04	151	85	4	edb2f59789c295838d2030b80c792cbea25eaa3d
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PCSK2 DOCK11 DHX38 COQ6	2.05e-04	152	85	4	0652ee3443e6fbb679d2c4f326239ae7c803f924
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal--glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTCHD1 SLC35F1 GNAS HSPA1L	2.15e-04	154	85	4	3211f003f4d1735c7cab9b6cc68af3e0bbfba35e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTCHD1 SLC35F1 GNAS HSPA1L	2.15e-04	154	85	4	c0fe767fc9ab45b2dfa71171f2a673a4a8decbaf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTCHD1 SLC35F1 GNAS HSPA1L	2.15e-04	154	85	4	4c2a7590791c2255b15dab82c3622f71f9ffd949
ToppCell	Children_(3_yrs)-Mesenchymal-chondrocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL11A1 SLC9A5 DLG4 BMPER	2.26e-04	156	85	4	60f1ce38e34b582f589db1e0d6139282c1902b2b
ToppCell	facs-Trachea-24m-Hematologic-myeloid-granulocyte\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RBM12B CD33 ITGAL ALOX5	2.32e-04	157	85	4	188d2f85babcd4eefe20e7a392d851b2e1185bab
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PARG R3HDM2 HSPA1L LIN7A	2.38e-04	158	85	4	6d2709b387945c015faa223c20d22b52a4082140
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD33 ITGAL ALOX5 SLC2A3	2.38e-04	158	85	4	d43b335e6aa12d84a75b988fbd6127ff1f4af25c
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD33 ITGAL ALOX5 SLC2A3	2.38e-04	158	85	4	ab12b29ce51ca2fcac469cc932391217d97145f9
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue-9\|TCGA-Colorectal / Sample_Type by Project: Shred V9	PCSK2 DPP6 PTCHD1 SLC35F1	2.43e-04	159	85	4	f376bf6cd0ed374211edac3c384f3a78f0caef2a
ToppCell	facs-Lung-EPCAM-3m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD33 ITGAL ALOX5 SLC2A3	2.49e-04	160	85	4	b73f07a0088936fbc3656a05710a67f38b4ae551
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HMSD PCSK2 ANKRD20A3P SLC35F1	2.49e-04	160	85	4	14dfa519e68bab4bce890ddb66fa7763f18d9f19
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HMSD PCSK2 ANKRD20A3P SLC35F1	2.49e-04	160	85	4	839bbdfd4e4c7b48260c8bfb7670378634405e1d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Neural\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HMSD PCSK2 ANKRD20A3P SLC35F1	2.49e-04	160	85	4	5b7789d4668ed7732babedc32d812233b430e0bd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HMSD PCSK2 ANKRD20A3P SLC35F1	2.49e-04	160	85	4	bba1486faaad5299e10f4fe17c6d149c28dc2560
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PFKFB2 HSPA1L ALOX5 SLC2A3	2.49e-04	160	85	4	bb1bb3673059768c0ea0160d29fff127f3a4ecb4
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD33 ITGAL ALOX5 SLC2A3	2.49e-04	160	85	4	b88876a58fea2066468e74dcc439c8561130a910
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PFKFB2 HSPA1L ALOX5 SLC2A3	2.49e-04	160	85	4	76f49b8b4450fa8acd36326bfa36a5d1f4bd95fb
ToppCell	BAL-Mild-cDC_5\|Mild / Compartment, Disease Groups and Clusters	LIN7B ITPKC TNFSF8 SLC2A3	2.55e-04	161	85	4	7a6e8ed0b5d999efce8945d8083ab01d71be9a92
ToppCell	facs-Lung-18m-Hematologic-myeloid-neutrophil\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD33 ITGAL ALOX5 SLC2A3	2.61e-04	162	85	4	ad974426039f4952c59d27167eac24dc6ce63f5e
ToppCell	facs-Lung-18m-Hematologic-myeloid-neutrophil-neutrophil\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD33 ITGAL ALOX5 SLC2A3	2.61e-04	162	85	4	4e7e565091bce227d794a36af2e5dfc4a791efad
ToppCell	TCGA-Stomach-Solid_Tissue_Normal-Stomach_normal_tissue-Stomach_normal_tissue-7\|TCGA-Stomach / Sample_Type by Project: Shred V9	COL4A6 DPP6 PTCHD1 BMPER	2.61e-04	162	85	4	b115b5799137122bd60696f8ae2aebadad6cd044
ToppCell	droplet-Fat-Gat-18m-Myeloid-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD33 ITGAL ALOX5 SLC2A3	2.68e-04	163	85	4	3d12a8ca97005308403a3ab136af483ab25f9b0e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK2 PDZD7 SLC35F1 DYNC1I1	2.80e-04	165	85	4	9de841c1c95967c562720feba930246debc626fd
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK2 PDZD7 SLC35F1 DYNC1I1	2.80e-04	165	85	4	a612a7d3a5415ecacc3df8fbff0ce498f982aad0
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK2 PDZD7 SLC35F1 DYNC1I1	2.80e-04	165	85	4	cdc94a640ec01c6892521bcd6f0ee0a66ff23866
ToppCell	facs-Lung-3m-Hematologic-myeloid-neutrophil-neutrophil\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD33 ITGAL ALOX5 SLC2A3	2.87e-04	166	85	4	3195035445d35d820f5e00dd03b029730478b024
ToppCell	facs-Lung-Endomucin-3m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD33 RAP1GAP2 ALOX5 SLC2A3	2.87e-04	166	85	4	5126d8f02314717eed341d867856fd4fe16c5118
ToppCell	facs-Lung-Endomucin-3m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD33 RAP1GAP2 ALOX5 SLC2A3	2.87e-04	166	85	4	3037bdca38c3a65eacfa644219cc43c54e303749
ToppCell	5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNJ12 DLG4 BMPER SLC2A3	2.87e-04	166	85	4	a42268a02a89fc97272e45c4cbe21acf04b7428c
ToppCell	facs-Lung-3m-Hematologic-myeloid-neutrophil\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD33 ITGAL ALOX5 SLC2A3	2.87e-04	166	85	4	6b6ecd70264b6bfbd8a3a378c965702829e2ecf1
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD33 RAP1GAP2 ALOX5 SLC2A3	3.00e-04	168	85	4	3611605114f6b668b44728d6563cd02389e106af
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK2 RAP1GAP2 SLC35F1 PCBP4	3.00e-04	168	85	4	95dc690c1987b05685d36e6bb20eb79308696e30
ToppCell	facs-Marrow-Granulocytes-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD33 RAP1GAP2 ALOX5 SLC2A3	3.07e-04	169	85	4	ee1969755180df58d32904e2bb4192da9373d03e
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue\|TCGA-Colorectal / Sample_Type by Project: Shred V9	PCSK2 DPP6 PTCHD1 GLDN	3.07e-04	169	85	4	41cb92b0558f0d5a3e511058efd9110258b88ee3
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue\|TCGA-Colorectal / Sample_Type by Project: Shred V9	PCSK2 DPP6 PTCHD1 GLDN	3.07e-04	169	85	4	91f4b6a14708e701b2af22989004282041777491
ToppCell	normal_Pleural_Fluid-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	SYNM MCF2L2 PCBP4 HSPA1L	3.07e-04	169	85	4	bea8aba1f3cc3d0e8d448c1c45f5354d26ebf850
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HMSD SPRED2 SLC35F1 DYNC1I1	3.35e-04	173	85	4	09a13407a41ff2cba82fc417b72bf9a24ce6c42e
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HMSD SPRED2 SLC35F1 DYNC1I1	3.35e-04	173	85	4	bfec038a6783f166240da4861e100643c6ea80a5
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GLDN DOCK11 ITGAL ALOX5	3.43e-04	174	85	4	d5c22b43531414951666ee7542a66ed9380e2d14
ToppCell	CTRL-Lymphoid-pDC\|Lymphoid / Disease state, Lineage and Cell class	GRIP1 SPRED2 RAP1GAP2 PFKFB2	3.43e-04	174	85	4	ff4315e9fad198cc323fc987deb8652da137cf98
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PCSK2 RAP1GAP2 R3HDM2 LIN7A	3.50e-04	175	85	4	ff0789f5913c9f3c49159e40b1ec3d2ff175ec9f
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK11 DHX38 RAP1GAP2 ITGAL	3.50e-04	175	85	4	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GLDN SLC35F1 PCBP4 SLC2A3	3.50e-04	175	85	4	bb898796662b97f7459b7dda7cecf6a9bde8b055
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL11A1 KCNJ12 BEX4 DYNC1I1	3.50e-04	175	85	4	f1394aacc8a94ca555dd19aaed5a18da99c6bf40
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL11A1 KCNJ12 BEX4 DYNC1I1	3.50e-04	175	85	4	7bf1194d93fbe2dbf9d953e0a32b2a6d88251ed1
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PCSK2 RAP1GAP2 R3HDM2 LIN7A	3.50e-04	175	85	4	21f8f11a8b874d4f7c47931010a2535f2a5a3373
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CD33 MCF2L2 BEX4 CDC42BPB	3.66e-04	177	85	4	946803293a7955116c80f403e99e4093e798ca3f
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK2 PTCHD1 DOCK11 GNAS	3.66e-04	177	85	4	1dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK2 PTCHD1 DOCK11 GNAS	3.66e-04	177	85	4	426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SYNM BMPER SLC35F1 LIN7A	3.74e-04	178	85	4	185b44700f06ec58b3c09c80520502166c965fd6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL11A1 BMPER PARP12 LIN7A	3.82e-04	179	85	4	c815eb9f760fe4ca7a5e49beb224659f0b864f22
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Hematopoietic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC168 SIRPB1 ITGAL ALOX5	3.82e-04	179	85	4	716856b2c7c660bf5ce00e63efeda6ed121f2baa
ToppCell	facs-Lung-Endomucin-24m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP31 DLG4 OLA1 CEP170B	3.82e-04	179	85	4	e520eadde4f1b7fb868dbbe94c4d62b3776c55eb
ToppCell	facs-Heart-RA-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIN7B GLDN KCNJ12 BEX4	3.82e-04	179	85	4	d76a05f1fee7f2f7b7b7994d3622e96f02b49432
ToppCell	facs-Heart-RA-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIN7B GLDN KCNJ12 BEX4	3.82e-04	179	85	4	6be47c877250968a916c711ba0787eb7b4c5443d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK2 DPP6 BEX4 DYNC1I1	3.90e-04	180	85	4	f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK2 COL11A1 SLC35F1 PCBP4	3.98e-04	181	85	4	098dbb3e0ff531c9720a233123250c1e39a97d4c
ToppCell	11.5-Distal-Immune-Immune\|Distal / Age, Tissue, Lineage and Cell class	TNFSF8 SIRPB1 ITGAL ALOX5	3.98e-04	181	85	4	193ee02f547a218b2fc13e1174ea4cff4f8a3450
ToppCell	Control-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A1	4.23e-04	184	85	4	c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCell	COPD-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A1	4.23e-04	184	85	4	42d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCell	Frontal_cortex-Neuronal-Excitatory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PCSK2 PTCHD1 RAP1GAP2 R3HDM2	4.23e-04	184	85	4	6e17c8151d6dc543de16d804db956c63c3fda414
ToppCell	P03-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PCSK2 GLDN DOCK11 SLC35F1	4.23e-04	184	85	4	8880ff36c243cc60a524d74934d000aef26a70ac
ToppCell	COPD-Myeloid-Macrophage_Alveolar\|World / Disease state, Lineage and Cell class	GLDN MCF2L2 CDC42BPB ALOX5	4.23e-04	184	85	4	7fd0b227c3750ffb80e41e92c60fcce46656be14
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK2 DPP6 BEX4 DYNC1I1	4.32e-04	185	85	4	70de48988c1f8e0809afc8092b663aa439d8e528
ToppCell	wk_08-11-Hematologic-Myeloid-Cycling_DC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CD33 SIRPB1 ITGAL ALOX5	4.41e-04	186	85	4	de1f0bc5dbf6dc0e716f5ebbf2bbcfe249811c54
ToppCell	IPF-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	ANKRD20A4P ANKRD20A2P ANKRD20A3P ANKRD20A1	4.41e-04	186	85	4	962c2dada19185628ead77c32fcb07fa95114247
Disease	Disorder of eye	GRIP1 EYS COL11A1 CDHR1 CDH23 PDZD7	2.66e-05	212	81	6	C0015397
Disease	SPARC-like protein 1 measurement	DSPP DHX38	1.11e-04	6	81	2	EFO_0008289
Disease	autosomal dominant nonsyndromic deafness (is_implicated_in)	COL11A1 ATP11A	4.03e-04	11	81	2	DOID:0050564 (is_implicated_in)
Disease	DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	CDH23 PDZD7	5.69e-04	13	81	2	C1846647
Disease	interstitial lung disease	DSPP RAP1GAP2 ATP11A	8.41e-04	67	81	3	EFO_0004244
Disease	disease free survival	CCDC168 SLC3A2	1.11e-03	18	81	2	EFO_0000409
Disease	severe acute respiratory syndrome, COVID-19	GRIP1 EYS RAP1GAP2 ATP11A EIF2AK2 LIN7A	1.46e-03	447	81	6	EFO_0000694, MONDO_0100096
Disease	progranulin measurement	GRIP1 CDH23	1.66e-03	22	81	2	EFO_0004625
Disease	Autism Spectrum Disorders	DPP6 PTCHD1 DLG4	1.67e-03	85	81	3	C1510586
Disease	nephrotic syndrome (implicated_via_orthology)	COQ6 ALOX5	1.98e-03	24	81	2	DOID:1184 (implicated_via_orthology)
Disease	health study participation	DPP6 KCNJ12 FPGT OLA1	2.07e-03	195	81	4	EFO_0010130
Disease	Neurodevelopmental Disorders	ILF2 DLG4 CDC42BPB	2.16e-03	93	81	3	C1535926
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement	PCSK7 PINX1 R3HDM2	2.30e-03	95	81	3	EFO_0004529, EFO_0008317, EFO_0008596

Protein segments in the cluster

Peptide	Gene	Start	Entry
GSSHEKGNRIVNGQG	ANKRD20A1	311	Q5TYW2
RHGESEFNLLGKIGG	PFKFB2	256	O60825
VAKDGGGRLHGADVV	CDHR1	211	Q96JP9
HNKESGFPGLRGEQG	COL4A6	451	Q14031
GGAKDIRGAVEAAHQ	ALDH16A1	561	Q8IZ83
NEEESRHLGGGEGQK	BEX4	31	Q9NWD9
GSSHEKGNRIVNGQG	ANKRD20A4P	311	Q4UJ75
EVKHGGEDGRNNSGA	ACBD5	376	Q5T8D3
KDGQAFHGENRIGGI	FGFR4	186	P22455
GADGHNSGVRQAVGI	COQ6	206	Q9Y2Z9
RGRQENTQDGHKGEG	DSPP	66	Q9NZW4
ERGEKGDHGELGLQG	GLDN	191	Q6ZMI3
KGPVQQDGELHGFRA	CEP170B	196	Q9Y4F5
VRAVDGGVGHNQKTG	CDH23	746	Q9H251
GQSGLKHGNRGKRQA	R3HDM2	836	Q9Y2K5
DGVIFLKHHDGRNNG	RBM12B	181	Q8IXT5
GHAGNFQAGEDGRIL	ITPKC	416	Q96DU7
VDIAGLVKGAHNGQG	OLA1	91	Q9NTK5
LVKGAHNGQGLGNAF	OLA1	96	Q9NTK5
GSSHEKGNRIVNGQG	ANKRD20A2P	311	Q5SQ80
SGAHIKIGNQAEGAG	PCBP4	271	P57723
GVAERHGGLKRGDQL	LIN7A	141	O14910
GVADRHGGLKRGDQL	LIN7B	126	Q9HAP6
GQKGHGLNGDDFLAV	EYS	2466	Q5T1H1
SGANGFGNGKVHTRR	KCNJ12	26	Q14500
LQGVKGGVDHAAAFG	GLOD4	201	Q9HC38
DGSGKQETRAGVVHG	CD33	246	P20138
GSKAGIGEVFEGHQG	DYNC1I1	471	O14576
LARGFGVDHGQVAEQ	MLYCD	91	O95822
INGHGAYGEKGQKGE	COL11A1	416	P12107
HRQFAILSGGRGEDG	MCF2L2	46	Q86YR7
QQEGGHEAGEGRGRQ	FBXO31	381	Q5XUX0
AALQHGVIAGRQGFG	PCSK7	306	Q16549
RVLFVGKGNGPHDNG	PLXNB2	166	O15031
GGEVRLHFQFEGGES	PARG	361	Q86W56
VDHGGLAEENGIKVG	PDZD7	241	Q9H5P4
KGKGLGAQEQGATDH	PINX1	41	Q96BK5
QRNPDFKGGVSIAGH	DDHD2	336	O94830
GLDKGGQGERHVLIF	HSPA1L	186	P34931
VKQGGRGAGATLEHQ	CDC42BPB	666	Q9Y5S2
HNSKGQQLDGRSRGG	MFAP3	86	P55082
QNGGKAVDERQLFHG	PARP12	551	Q9H0J9
GEGQQHHLGGAKQVR	FGG	421	P02679
GSSHEKGNRIVNGQG	ANKRD20A3P	311	Q5VUR7
GIGEELAIHNRGKEG	CFDP1	256	Q9UEE9
NGHKRDDLIGGDGNF	BMPER	501	Q8N8U9
FQNGHGIKREDSRGS	DOCK11	1226	Q5JSL3
GGFGQVFKAKHRIDG	EIF2AK2	276	P19525
QTGGIYVHEKGRGQF	FBXO11	501	Q86XK2
LSHGGFRKILGQEGD	ILF2	321	Q12905
RILHVNGFNGEGGEE	GNAS	61	P63092
RIGDLQAFQGHGAGN	SLC3A2	226	P08195
QAFQGHGAGNLAGLK	SLC3A2	231	P08195
EGGAAHKDGRLQIGD	DLG4	196	P78352
EGQAHGADRSGKDGV	SLC2A3	466	P11169
IGGEDGDIHRGFQSL	HMSD	31	A8MTL9
LHVNIGGQGRKEHEG	CCDC168	5401	Q8NDH2
DGRGSGFQGTKLLHE	DPP6	661	P42658
HKEGNTFGFVIRGGA	GRIP1	156	Q9Y3R0
GQAGKEAEKLGHGVN	SBSN	106	Q6UWP8
GHGVNNAAGQVGKEA	SBSN	116	Q6UWP8
GQAGNEAGRFGQGVH	SBSN	161	Q6UWP8
GQAGNEAGRFGQGVH	SBSN	251	Q6UWP8
GQAGKEGDIAVHGVQ	SBSN	431	Q6UWP8
HVFVDPAGAKIGNGG	FPGT	86	O14772
GQHGGFVVTVKQERG	HMG20B	21	Q9P0W2
SGANGFGNGKVHTRR	KCNJ18	26	B7U540
QDFKGFRGGLDVTHG	RAP1GAP2	301	Q684P5
KASAGEGDQAHREQG	SYNM	1506	O15061
LFDKANATGGGGHVQ	ALOX5	421	P09917
KDGRAVYNGHQLGGV	PTCHD1	181	Q96NR3
FEGNFVHGEKNGRGK	SETD7	36	Q8WTS6
ANAEATNGKHRGLGF	SLC9A5	676	Q14940
FGRSIHGVKDLEGDG	ITGAL	581	P20701
AHVGIGVIGKEGRQA	ATP11A	836	P98196
AGAGRELIYNQKEGH	SIRPB1	71	O00241
GADVLVGRHQGAGEN	SLC35F1	201	Q5T1Q4
VGRHQGAGENKLVGD	SLC35F1	206	Q5T1Q4
NKDGILHGVRYQDGN	TNFSF8	116	P32971
SVDECKGHQGGFNGL	ZNF138	56	P52744
EKHNAQGQGNGLRYG	PPM1A	11	P35813
VGGRGHVAIKAGQEE	TSPYL1	86	Q9H0U9
YGFREGQGLGKHEQG	RBM17	246	Q96I25
GNGRSGFLIHGERQK	SPRED2	51	Q7Z698
GGDQAGQNIRKDRHY	DHX38	96	Q92620
QEKGDFTGHGERKGR	TCF20	731	Q9UGU0
EGEILQAFRGHQGRG	WDR6	286	Q9NNW5
HQSGRLEETAGKGAG	ZNF687	881	Q8N1G0
VSQARAGEGRGAGKH	USP31	1181	Q70CQ4
NLESGGQNRVARGHG	ZNF407	1276	Q9C0G0
EGQVKTTRGLGFHGN	PP2D1	411	A8MPX8
GGEDKARQVAAEHGF	PCSK2	41	P16519