Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF823 RLF ZNF12 ZNF136 ZNF20 ZNF560 ZBTB48 ZFP30 ZNF846 ZNF737 ZBTB5 ZNF528 SNAI1 ZNF625 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF491 ZNF829 ZNF404	2.29e-12	1412	53	22	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF823 ZNF12 ZNF136 ZNF20 ZNF560 ZBTB48 ZFP30 ZNF846 ZNF737 ZBTB5 ZNF528 SNAI1 ZNF625 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF491 ZNF829 ZNF404	3.92e-11	1459	53	21	GO:0000977
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	GRIN2B GRM5	4.13e-05	4	53	2	GO:0099583
GeneOntologyMolecularFunction	glutamate receptor activity	GRIN2B GRIN3A GRM5	4.94e-05	27	53	3	GO:0008066
GeneOntologyMolecularFunction	NMDA glutamate receptor activity	GRIN2B GRIN3A	1.92e-04	8	53	2	GO:0004972
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF12 ZNF136 ZBTB48 ZFP30 ZNF737 ZNF528 SNAI1 ZNF626 ZNF844 ZNF354C ZNF829	3.54e-04	1244	53	11	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF12 ZNF136 ZBTB48 ZFP30 ZNF737 ZNF528 SNAI1 ZNF626 ZNF844 ZNF354C ZNF829	4.26e-04	1271	53	11	GO:0000987
GeneOntologyMolecularFunction	glycine binding	GRIN2B GRIN3A	6.16e-04	14	53	2	GO:0016594
GeneOntologyMolecularFunction	glutamate-gated receptor activity	GRIN2B GRIN3A	9.16e-04	17	53	2	GO:0004970
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GRIN2B GRIN3A GRM5	1.04e-03	75	53	3	GO:0098960
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	P2RX5 GRIN2B GRIN3A	1.12e-03	77	53	3	GO:0005230
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2A NSD3	1.27e-03	20	53	2	GO:0042800
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GRIN2B GRIN3A GRM5	2.38e-03	100	53	3	GO:0030594
GeneOntologyBiologicalProcess	regulation of brain-derived neurotrophic factor-activated receptor activity	FAM72D FAM72C FAM72A FAM72B	3.31e-11	4	51	4	GO:0031551
GeneOntologyBiologicalProcess	negative regulation of brain-derived neurotrophic factor receptor signaling pathway	FAM72D FAM72C FAM72A FAM72B	1.65e-10	5	51	4	GO:0031549
GeneOntologyBiologicalProcess	regulation of brain-derived neurotrophic factor receptor signaling pathway	FAM72D FAM72C FAM72A FAM72B	1.15e-09	7	51	4	GO:0031548
GeneOntologyBiologicalProcess	brain-derived neurotrophic factor receptor signaling pathway	FAM72D FAM72C FAM72A FAM72B	3.26e-08	14	51	4	GO:0031547
GeneOntologyBiologicalProcess	regulation of protein tyrosine kinase activity	FAM72D FAM72C FAM72A GRM5 FAM72B	7.54e-07	69	51	5	GO:0061097
GeneOntologyBiologicalProcess	negative regulation of protein tyrosine kinase activity	FAM72D FAM72C FAM72A FAM72B	8.66e-07	30	51	4	GO:0061099
GeneOntologyBiologicalProcess	negative regulation of signaling receptor activity	FAM72D FAM72C FAM72A FAM72B	1.29e-06	33	51	4	GO:2000272
GeneOntologyBiologicalProcess	negative regulation of peptidyl-tyrosine phosphorylation	FAM72D FAM72C FAM72A FAM72B	1.36e-05	59	51	4	GO:0050732
GeneOntologyBiologicalProcess	negative regulation of heterochromatin formation	RLF KMT2A	8.93e-05	6	51	2	GO:0031452
GeneOntologyBiologicalProcess	negative regulation of chromatin organization	RLF KMT2A	1.25e-04	7	51	2	GO:1905268
GeneOntologyBiologicalProcess	regulation of signaling receptor activity	FAM72D FAM72C FAM72A FAM72B	3.08e-04	131	51	4	GO:0010469
GeneOntologyBiologicalProcess	glutamate receptor signaling pathway	GRIN2B GRIN3A GRM5	4.20e-04	59	51	3	GO:0007215
GeneOntologyBiologicalProcess	regulation of postsynaptic cytosolic calcium ion concentration	GRIN2B GRM5	4.59e-04	13	51	2	GO:0099566
GeneOntologyBiologicalProcess	regulation of peptidyl-tyrosine phosphorylation	FAM72D FAM72C FAM72A GRM5 FAM72B	5.50e-04	272	51	5	GO:0050730
GeneOntologyCellularComponent	NMDA selective glutamate receptor complex	GRIN2B GRIN3A	2.24e-04	9	53	2	GO:0017146
HumanPheno	Aplasia/Hypoplasia of the middle phalanges of the hand	MEGF8 KMT2A DOCK6	3.35e-05	62	6	3	HP:0009843
HumanPheno	Abnormal middle phalanx morphology of the hand	MEGF8 KMT2A DOCK6	5.48e-05	73	6	3	HP:0009833
HumanPheno	Mild microcephaly	CEP85L GRIN2B	1.56e-04	17	6	2	HP:0040196
HumanPheno	Short phalanx of finger	MEGF8 KMT2A DOCK6 ALG6	1.74e-04	306	6	4	HP:0009803
HumanPheno	Aplasia/Hypoplasia of the phalanges of the hand	MEGF8 KMT2A DOCK6 ALG6	2.05e-04	319	6	4	HP:0009767
HumanPheno	Axial hypotonia	CEP85L GRIN2B DOCK6 ALG6	2.45e-04	334	6	4	HP:0008936
HumanPheno	Aplasia/Hypoplasia of fingers	MEGF8 KMT2A DOCK6 ALG6	3.50e-04	366	6	4	HP:0006265
MousePheno	abnormal somatic hypermutation frequency	FAM72D FAM72C FAM72A FAM72B	9.73e-08	19	33	4	MP:0004815
MousePheno	increased B cell apoptosis	FAM72D FAM72C FAM72A FAM72B	5.06e-07	28	33	4	MP:0008782
MousePheno	increased germinal center B cell number	FAM72D FAM72C FAM72A FAM72B	7.74e-07	31	33	4	MP:0008177
MousePheno	abnormal B cell apoptosis	FAM72D FAM72C FAM72A FAM72B	4.27e-06	47	33	4	MP:0008781
MousePheno	abnormal germinal center B cell morphology	FAM72D FAM72C FAM72A FAM72B	8.06e-06	55	33	4	MP:0008176
MousePheno	abnormal germinal center B cell number	FAM72D FAM72C FAM72A FAM72B	8.06e-06	55	33	4	MP:0013680
MousePheno	abnormal class switch recombination	FAM72D FAM72C FAM72A FAM72B	3.77e-05	81	33	4	MP:0004816
MousePheno	polycystic kidney	FAM72D FAM72C FAM72A FAM72B	6.21e-05	92	33	4	MP:0008528
MousePheno	abnormal B cell differentiation	FAM72D FAM72C FAM72A KMT2A FAM72B	5.22e-04	287	33	5	MP:0002144
MousePheno	increased mature B cell number	FAM72D FAM72C FAM72A FAM72B	6.27e-04	168	33	4	MP:0008210
MousePheno	kidney cyst	FAM72D FAM72C FAM72A FAM72B	7.63e-04	177	33	4	MP:0003675
Domain	-	ZNF823 RLF ZNF12 ZNF136 ZNF20 ZNF800 ZNF560 ZBTB48 ZFP30 ZNF846 ZNF737 ZBTB5 ZNF528 SNAI1 ZNF625 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF491 ZNF829 ZNF404	1.21e-19	679	53	23	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF823 RLF ZNF12 ZNF136 ZNF20 ZNF800 ZNF560 ZBTB48 ZFP30 ZNF846 ZNF737 ZBTB5 ZNF528 SNAI1 ZNF625 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF491 ZNF829 ZNF404	1.97e-19	694	53	23	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF823 RLF ZNF12 ZNF136 ZNF20 ZNF800 ZNF560 ZBTB48 ZFP30 ZNF846 ZNF737 ZBTB5 ZNF528 SNAI1 ZNF625 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF491 ZNF829 ZNF404	2.28e-18	775	53	23	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF823 RLF ZNF12 ZNF136 ZNF20 ZNF800 ZNF560 ZBTB48 ZFP30 ZNF846 ZNF737 ZBTB5 ZNF528 SNAI1 ZNF625 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF491 ZNF829 ZNF404	2.41e-18	777	53	23	PS00028
Domain	zf-C2H2	ZNF823 RLF ZNF12 ZNF136 ZNF20 ZNF560 ZBTB48 ZFP30 ZNF846 ZNF737 ZBTB5 ZNF528 SNAI1 ZNF625 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF491 ZNF829 ZNF404	3.81e-18	693	53	22	PF00096
Domain	Znf_C2H2-like	ZNF823 RLF ZNF12 ZNF136 ZNF20 ZNF800 ZNF560 ZBTB48 ZFP30 ZNF846 ZNF737 ZBTB5 ZNF528 SNAI1 ZNF625 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF491 ZNF829 ZNF404	4.12e-18	796	53	23	IPR015880
Domain	Znf_C2H2	ZNF823 RLF ZNF12 ZNF136 ZNF20 ZNF800 ZNF560 ZBTB48 ZFP30 ZNF846 ZNF737 ZBTB5 ZNF528 SNAI1 ZNF625 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF491 ZNF829 ZNF404	5.27e-18	805	53	23	IPR007087
Domain	ZnF_C2H2	ZNF823 RLF ZNF12 ZNF136 ZNF20 ZNF800 ZNF560 ZBTB48 ZFP30 ZNF846 ZNF737 ZBTB5 ZNF528 SNAI1 ZNF625 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF491 ZNF829 ZNF404	5.72e-18	808	53	23	SM00355
Domain	zf-C2H2_6	ZNF823 ZNF12 ZNF136 ZNF20 ZNF560 ZBTB48 ZFP30 ZNF846 ZNF737 SNAI1 ZNF625 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF404	8.31e-18	314	53	17	PF13912
Domain	KRAB	ZNF823 ZNF12 ZNF136 ZNF20 ZNF560 ZFP30 ZNF846 ZNF737 ZNF528 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF829 ZNF404	1.85e-15	358	53	16	PS50805
Domain	KRAB	ZNF823 ZNF12 ZNF136 ZNF20 ZNF560 ZFP30 ZNF846 ZNF737 ZNF528 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF829 ZNF404	1.85e-15	358	53	16	PF01352
Domain	KRAB	ZNF823 ZNF12 ZNF136 ZNF20 ZNF560 ZFP30 ZNF846 ZNF737 ZNF528 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF829 ZNF404	2.98e-15	369	53	16	SM00349
Domain	KRAB	ZNF823 ZNF12 ZNF136 ZNF20 ZNF560 ZFP30 ZNF846 ZNF737 ZNF528 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF829 ZNF404	3.11e-15	370	53	16	IPR001909
Domain	FAM72	FAM72D FAM72C FAM72A FAM72B	5.78e-11	4	53	4	PF14976
Domain	FAM72	FAM72D FAM72C FAM72A FAM72B	5.78e-11	4	53	4	IPR026768
Domain	Peripla_BP_I	GRIN2B GRIN3A GRM5	1.83e-04	39	53	3	IPR028082
Domain	EGF_extracell	NELL2 ADAM18 ADAM32	6.59e-04	60	53	3	IPR013111
Domain	EGF_2	NELL2 ADAM18 ADAM32	6.59e-04	60	53	3	PF07974
Domain	Znf_FYVE_PHD	SPIRE2 ZFYVE9 KMT2A NSD3	8.00e-04	147	53	4	IPR011011
Domain	Post-SET_dom	KMT2A NSD3	9.24e-04	16	53	2	IPR003616
Domain	PostSET	KMT2A NSD3	9.24e-04	16	53	2	SM00508
Domain	POST_SET	KMT2A NSD3	9.24e-04	16	53	2	PS50868
Domain	Disintegrin_CS	ADAM18 ADAM32	9.24e-04	16	53	2	IPR018358
Domain	Iontro_rcpt	GRIN2B GRIN3A	1.17e-03	18	53	2	IPR001320
Domain	Lig_chan	GRIN2B GRIN3A	1.17e-03	18	53	2	PF00060
Domain	Lig_chan-Glu_bd	GRIN2B GRIN3A	1.17e-03	18	53	2	PF10613
Domain	ADAM_CR	ADAM18 ADAM32	1.17e-03	18	53	2	PF08516
Domain	PBPe	GRIN2B GRIN3A	1.17e-03	18	53	2	SM00079
Domain	Iono_rcpt_met	GRIN2B GRIN3A	1.17e-03	18	53	2	IPR001508
Domain	Glu/Gly-bd	GRIN2B GRIN3A	1.17e-03	18	53	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIN2B GRIN3A	1.17e-03	18	53	2	SM00918
Domain	-	ADAM18 ADAM32	1.45e-03	20	53	2	4.10.70.10
Domain	DISIN	ADAM18 ADAM32	1.60e-03	21	53	2	SM00050
Domain	Disintegrin	ADAM18 ADAM32	1.60e-03	21	53	2	PF00200
Domain	ADAM_Cys-rich	ADAM18 ADAM32	2.65e-03	27	53	2	IPR006586
Domain	ACR	ADAM18 ADAM32	2.65e-03	27	53	2	SM00608
Domain	EGF_3	NELL2 MEGF8 ADAM18 ADAM32	4.42e-03	235	53	4	PS50026
Domain	ANF_receptor	GRIN2B GRM5	4.94e-03	37	53	2	PF01094
Domain	ANF_lig-bd_rcpt	GRIN2B GRM5	4.94e-03	37	53	2	IPR001828
Domain	EGF-like_dom	NELL2 MEGF8 ADAM18 ADAM32	5.41e-03	249	53	4	IPR000742
Domain	Peptidase_M12B_N	ADAM18 ADAM32	5.47e-03	39	53	2	IPR002870
Domain	Pep_M12B_propep	ADAM18 ADAM32	5.47e-03	39	53	2	PF01562
Domain	DISINTEGRIN_1	ADAM18 ADAM32	5.75e-03	40	53	2	PS00427
Domain	-	CPSF4L DHX57	5.75e-03	40	53	2	4.10.1000.10
Domain	ADAM_MEPRO	ADAM18 ADAM32	5.75e-03	40	53	2	PS50215
Domain	DISINTEGRIN_2	ADAM18 ADAM32	5.75e-03	40	53	2	PS50214
Domain	Reprolysin	ADAM18 ADAM32	5.75e-03	40	53	2	PF01421
Domain	Peptidase_M12B	ADAM18 ADAM32	5.75e-03	40	53	2	IPR001590
Domain	EGF_1	NELL2 MEGF8 ADAM18 ADAM32	5.88e-03	255	53	4	PS00022
Domain	SET	KMT2A NSD3	6.04e-03	41	53	2	PF00856
Domain	Disintegrin_dom	ADAM18 ADAM32	6.04e-03	41	53	2	IPR001762
Domain	EGF-like_CS	NELL2 MEGF8 ADAM18 ADAM32	6.38e-03	261	53	4	IPR013032
Domain	EGF_2	NELL2 MEGF8 ADAM18 ADAM32	6.73e-03	265	53	4	PS01186
Domain	SET	KMT2A NSD3	7.55e-03	46	53	2	SM00317
Domain	ZnF_C3H1	CPSF4L DHX57	8.20e-03	48	53	2	SM00356
Domain	zf-CCCH	CPSF4L DHX57	8.53e-03	49	53	2	PF00642
Domain	SET_dom	KMT2A NSD3	8.87e-03	50	53	2	IPR001214
Domain	SET	KMT2A NSD3	8.87e-03	50	53	2	PS50280
Domain	Znf_CCCH	CPSF4L DHX57	1.18e-02	58	53	2	IPR000571
Domain	ZF_C3H1	CPSF4L DHX57	1.18e-02	58	53	2	PS50103
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF12 ZNF136 ZNF20 ZNF560 ZFP30 ZNF737 KMT2A ZNF528 GRIN2B ZNF625 ZNF626 CDC27 ZNF25 ZNF443 ZNF354C	1.36e-07	1387	33	15	M734
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF823 ZNF12 ZNF136 ZFP30 KMT2A ZNF844 ZNF25 ZNF354C	3.08e-04	768	33	8	MM14851
Pubmed	Fam72a enforces error-prone DNA repair during antibody diversification.	FAM72D FAM72C FAM72A FAM72B	5.19e-12	4	54	4	34819671
Pubmed	Identification and characterisation of the novel amyloid-beta peptide-induced protein p17.	FAM72D FAM72C FAM72A FAM72B	2.59e-11	5	54	4	19755123
Pubmed	All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci.	FAM72D FAM72C FAM72A FAM72B	2.59e-11	5	54	4	26206078
Pubmed	FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.	FAM72D FAM72C FAM72A FAM72B	7.76e-11	6	54	4	34819670
Pubmed	cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.	FAM72D FAM72C FAM72A FAM72B	6.99e-09	15	54	4	1741163
Pubmed	Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2-/- Mice.	GRIN2B GRIN3A GRM5	1.95e-06	16	54	3	30466882
Pubmed	Correlations between GRIN2B and GRIN3A gene polymorphisms and postpartum depressive symptoms in Chinese parturients undergoing cesarean section: A prospective cohort study.	GRIN2B GRIN3A	2.37e-06	2	54	2	36898314
Pubmed	Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices.	GRIN2B GRM5	2.37e-06	2	54	2	21310164
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIN2B GRIN3A GRM5	7.00e-06	24	54	3	35746896
Pubmed	mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch.	GRIN2B GRM5	7.09e-06	3	54	2	21521618
Pubmed	Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors.	GRIN2B GRIN3A	7.09e-06	3	54	2	17047094
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF136 ZNF20 ZNF737 ZNF626 ZNF25	9.29e-06	181	54	5	37372979
Pubmed	Analysis of NR3A receptor subunits in human native NMDA receptors.	GRIN2B GRIN3A	1.42e-05	4	54	2	17997397
Pubmed	Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits.	GRIN2B GRIN3A	1.42e-05	4	54	2	12391275
Pubmed	An NMDA receptor signaling complex with protein phosphatase 2A.	GRIN2B GRIN3A	1.42e-05	4	54	2	11588171
Pubmed	Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression.	GRIN2B GRM5	1.42e-05	4	54	2	24925192
Pubmed	Enhanced ethanol inhibition of recombinant N-methyl-D-aspartate receptors by magnesium: role of NR3A subunits.	GRIN2B GRIN3A	1.42e-05	4	54	2	18445116
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF12 ZNF20 ZNF25	1.54e-05	31	54	3	2288909
Pubmed	HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons.	GRIN2B GRIN3A	4.94e-05	7	54	2	11606043
Pubmed	HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity.	GRIN2B GRIN3A	4.94e-05	7	54	2	11483648
Pubmed	Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats.	GRIN2B GRIN3A	4.94e-05	7	54	2	10197777
Pubmed	The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site.	GRIN2B GRIN3A	4.94e-05	7	54	2	14644469
Pubmed	Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor.	GRIN2B GRIN3A	4.94e-05	7	54	2	12414113
Pubmed	Human immunodeficiency virus type 1 Tat protein directly activates neuronal N-methyl-D-aspartate receptors at an allosteric zinc-sensitive site.	GRIN2B GRIN3A	4.94e-05	7	54	2	12775422
Pubmed	Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.	GRIN2B GRIN3A	4.94e-05	7	54	2	7569905
Pubmed	HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors.	GRIN2B GRIN3A	4.94e-05	7	54	2	22940423
Pubmed	Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons.	GRIN2B GRIN3A	6.59e-05	8	54	2	8804048
Pubmed	HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism.	GRIN2B GRIN3A	6.59e-05	8	54	2	9651389
Pubmed	Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.	GRIN2B GRIN3A	6.59e-05	8	54	2	8724036
Pubmed	The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.	GRIN2B GRIN3A	6.59e-05	8	54	2	8845955
Pubmed	The human immunodeficiency virus-1 protein transactivator of transcription up-regulates N-methyl-D-aspartate receptor function by acting at metabotropic glutamate receptor 1 receptors coexisting on human and rat brain noradrenergic neurones.	GRIN2B GRIN3A	6.59e-05	8	54	2	16489129
Pubmed	Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.	GRIN2B GRIN3A	6.59e-05	8	54	2	8822372
Pubmed	Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.	GRIN2B GRIN3A	6.59e-05	8	54	2	21106831
Pubmed	HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons.	GRIN2B GRIN3A	6.59e-05	8	54	2	8563977
Pubmed	HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures.	GRIN2B GRIN3A	6.59e-05	8	54	2	8821747
Pubmed	Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures.	GRIN2B GRIN3A	6.59e-05	8	54	2	10448428
Pubmed	Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.	GRIN2B GRM5	6.59e-05	8	54	2	18606955
Pubmed	Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.	GRIN2B GRIN3A	6.59e-05	8	54	2	7695237
Pubmed	Characterization of a mouse multigene family that encodes zinc finger structures.	ZNF12 ZNF25	6.59e-05	8	54	2	2452975
Pubmed	Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.	GRIN2B GRIN3A	6.59e-05	8	54	2	8955056
Pubmed	Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system.	GRIN2B GRIN3A	6.59e-05	8	54	2	10555109
Pubmed	A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.	GRIN2B GRM5	8.46e-05	9	54	2	28130356
Pubmed	D1/NMDA receptors and concurrent methamphetamine+ HIV-1 Tat neurotoxicity.	GRIN2B GRIN3A	8.46e-05	9	54	2	22552781
Pubmed	Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS.	GRIN2B GRIN3A	8.46e-05	9	54	2	21491143
Pubmed	Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity.	GRIN2B GRIN3A	8.46e-05	9	54	2	16554481
Pubmed	N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons.	GRIN2B GRIN3A	1.06e-04	10	54	2	19332541
Pubmed	Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations.	ADAM18 ADAM32	1.29e-04	11	54	2	24079728
Pubmed	Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.	GRIN2B GRIN3A	1.29e-04	11	54	2	8581564
Pubmed	HIV-1 Tat-mediated apoptosis in human blood-retinal barrier-associated cells.	GRIN2B GRIN3A	1.29e-04	11	54	2	24739951
Pubmed	Effects of SDF-1alpha and gp120IIIB on apoptotic pathways in SK-N-SH neuroblastoma cells.	GRIN2B GRIN3A	1.29e-04	11	54	2	16481105
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	RLF TCAF2 ZBTB5 KMT2A CDC27	1.63e-04	331	54	5	19490893
Pubmed	Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways.	GRIN2B GRIN3A	2.13e-04	14	54	2	15749123
Pubmed	Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.	GRIN2B GRM5	2.13e-04	14	54	2	21795692
Pubmed	Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation.	GRIN2B GRIN3A	2.13e-04	14	54	2	31712124
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZBTB48 ZBTB5 SNAI1 ZNF626 ZNF844 ZNF25 ZNF354C	2.44e-04	808	54	7	20412781
Pubmed	Neurotoxicity of human immunodeficiency virus-1: viral proteins and axonal transport.	GRIN2B GRIN3A	2.45e-04	15	54	2	21948112
Pubmed	Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.	KMT2A CDC27	2.45e-04	15	54	2	16510875
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GRIN2B GRIN3A GRM5	2.77e-04	81	54	3	22723691
Pubmed	Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.	GRIN2B GRIN3A	3.17e-04	17	54	2	24086760
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	RLF ZNF12 ZNF136 KMT2A CDC27 NSD3	3.53e-04	608	54	6	36089195
Pubmed	Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.	ZNF12 ZNF136	4.88e-04	21	54	2	7865130
Pubmed	The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.	GRIN2B GRIN3A	4.88e-04	21	54	2	22114277
Pubmed	Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.	CEP85L SMG6	6.39e-04	24	54	2	19584346
Pubmed	Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.	GRIN2B GRIN3A	7.51e-04	26	54	2	9745929
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	GRIN2B GRIN3A GRM5	8.32e-04	118	54	3	19156168
Pubmed	Dissection of behavior and psychiatric disorders using the mouse as a model.	GRIN2B GRM5	1.07e-03	31	54	2	10767319
Pubmed	Role of Tat protein in HIV neuropathogenesis.	GRIN2B GRIN3A	1.21e-03	33	54	2	19526283
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	ZNF800 KMT2A DHX57 CDC27 NSD3	1.41e-03	533	54	5	30554943
Interaction	KRTAP10-7 interactions	ZNF20 ZBTB48 ZNF846 DHX57 ZNF625 ZNF844 ZNF491	1.11e-05	293	53	7	int:KRTAP10-7
Cytoband	19p13.2	ZNF823 ZNF136 ZNF20 ZNF560 ZNF846 ZNF625 ZNF844 DOCK6 ZNF443 ZNF491	1.55e-13	229	54	10	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF823 ZNF136 ZNF20 ZNF560 ZNF846 ZNF625 ZNF844 DOCK6 ZNF443 ZNF491	2.82e-08	797	54	10	chr19p13
Cytoband	8p11.22	ADAM18 ADAM32	1.22e-04	14	54	2	8p11.22
Cytoband	Ensembl 112 genes in cytogenetic band chr8p11	ADAM18 ADAM32 NSD3	2.50e-04	103	54	3	chr8p11
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF823 RLF ZNF12 ZNF136 ZNF20 ZNF800 ZNF560 ZBTB48 ZFP30 ZNF846 ZNF737 ZBTB5 ZNF528 SNAI1 ZNF625 ZNF626 ZNF844 ZNF25 ZNF443 ZNF354C ZNF491 ZNF829 ZNF404	3.73e-23	718	38	23	28
GeneFamily	Glutamate ionotropic receptor NMDA type subunits	GRIN2B GRIN3A	8.97e-05	7	38	2	1201
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM18 ADAM32	1.46e-03	27	38	2	47
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2A NSD3	2.31e-03	34	38	2	487
GeneFamily	PHD finger proteins	KMT2A NSD3	1.53e-02	90	38	2	88
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB48 ZBTB5	3.22e-02	134	38	2	861
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SPIRE2 FAM72C ZFP30 FAM72A FAM72B	4.27e-06	199	54	5	c6d59ed26eadd3c41acfe1b4d929270e00ea3e95
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Papillary-5\|TCGA-Stomach / Sample_Type by Project: Shred V9	ZNF823 ZNF136 ZNF20 ZNF625	1.01e-05	111	54	4	eb737146969b70c619649f244998d4183237c763
ToppCell	Healthy-CD4+_T_activated\|World / disease group, cell group and cell class	SPIRE2 ZFYVE9 GRIN3A ZNF354C	2.52e-05	140	54	4	407691970ec72a3afb45e431cf48814546b8acff
ToppCell	Healthy-CD4+_T_activated\|Healthy / disease group, cell group and cell class	SPIRE2 ZFYVE9 GRIN3A ZNF354C	2.89e-05	145	54	4	45e8089fdf7d6f69b383816d8945e39fba24c873
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-6\|TCGA-Kidney / Sample_Type by Project: Shred V9	FAM72D FAM72C FAM72A FAM72B	3.84e-05	156	54	4	d249747c7108a0edfc72d24c09b0b0e4ed662b40
ToppCell	CV-Mild-4\|Mild / Virus stimulation, Condition and Cluster	ZNF12 TCAF2 ZFYVE9 SPDYA	4.24e-05	160	54	4	2e24f8de5086b086863d3bf4d9afbd9bc93f4d5e
ToppCell	Severe-Lymphoid-NK-\|Severe / Condition, Lineage, Cell class and cell subclass	ZNF136 ZFP30 ZBTB5 ZNF625	4.24e-05	160	54	4	d276c6cb8317d5fb19e7b4fe5238abaf0272d4c6
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____fenestrated_capillary_endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZBTB48 CEP85L SNAI1 ZNF25	6.70e-05	180	54	4	79c5725f02e038d0187f4a1e1591f2492538aa57
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-5\|TCGA-Liver / Sample_Type by Project: Shred V9	FAM72D FAM72C FAM72A FAM72B	7.15e-05	183	54	4	f604a8b62c7088fad8365dbf8d910fc980bd3ba8
ToppCell	343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FAM72D MEGF8 FAM72C FAM72B	7.15e-05	183	54	4	f03d87b556a3d50360d4eb6126b3466fe7266677
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RLF CEP85L KMT2A SMG6	7.93e-05	188	54	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-D\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FAM72D FAM72A ZNF625 FAM72B	8.60e-05	192	54	4	90d25b0b38f1cd7a98c76c1f9e38166da6d7a316
ToppCell	proximal-Hematologic-Proliferating_NK/T\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAM72D FAM72C SPDYA FAM72B	9.69e-05	198	54	4	6c894fda309ec3d4bb446f63d5dde4e7f8c4fd89
ToppCell	proximal-3-Hematologic-Proliferating_NK/T\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAM72D FAM72C SPDYA FAM72B	9.69e-05	198	54	4	2777c5efe84ce3dbbe6175ecc1c987bc816ab74b
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	FAM72D FAM72C CDC27 FAM72B	9.69e-05	198	54	4	629d674a9c9108c1acb3f7af57bbdbf34bb0528e
ToppCell	proximal-Hematologic-Proliferating_NK/T-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAM72D FAM72C SPDYA FAM72B	9.69e-05	198	54	4	2e121899f58a5024e26441bd326aac12c37fe6d1
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_dorsal_progenitors\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	FAM72D FAM72C CDC27 FAM72B	9.69e-05	198	54	4	5f0964c3aa7e1dc52cbb46e754078920b65bcb88
Computational	Genes in the cancer module 123.	RLF ZNF136 ZBTB48 KMT2A	3.98e-04	247	16	4	MODULE_123
Disease	neuroblastoma, cutaneous melanoma	SPIRE2 UGT1A6	1.03e-03	28	50	2	EFO_0000389, EFO_0000621
Disease	obsolete aging	GRIN2B GRM5 ZNF25 ALG6	1.28e-03	279	50	4	GO_0007568

Protein segments in the cluster

Peptide	Gene	Start	Entry
KLYKCGECEKAFNCR	ZNF354C	326	Q86Y25
ILSCCLHYCKDKAKD	SMG6	1356	Q86US8
GSLEKLCKLDYACKL	CXorf66	186	Q5JRM2
CNFFTKGLCEKGKLC	CPSF4L	41	A6NMK7
YCCCLKEISTKKKIA	ALG6	131	Q9Y672
KCCDYNTCKLKGSVK	ADAM18	416	Q9Y3Q7
LKDGAKCYKGLCCKD	ADAM32	426	Q8TC27
CKICCSQYDKDGKKI	PGBD4	541	Q96DM1
CLGYLCTFCLIAKPK	GRM5	626	P41594
KSALAYVDGKCCKEC	NELL2	316	Q99435
TGRCYFTKICKCKLK	FAM72D	56	Q6L9T8
KKLLCRKCKALACYT	DDX58	806	O95786
CLQGYFLLDGKCTKC	MEGF8	2366	Q7Z7M0
TGRCYFTKICKCKLK	FAM72A	56	Q5TYM5
KFKKCCYGYCIDLLE	GRIN3A	571	Q8TCU5
RLCFKDFCKKCEDAL	DOCK6	1971	Q96HP0
SLEICKFYLKGNCKF	DHX57	301	Q6P158
TGRCYFTKICKCKLK	FAM72C	56	H0Y354
FKEMSCCLFDLKALC	CEP85L	716	Q5SZL2
KLFAKGNFCPLCDKC	KMT2A	1561	Q03164
CKYLLAKCCVDLSKL	CDC27	71	P30260
FLLSYCDCKIFKICL	GSTCD	36	Q8NEC7
SKKKPRLFCDICDCF	CLIP1	1371	P30622
TGRCYFTKICKCKLK	FAM72B	56	Q86X60
CKGLCLSLFDYKTEK	P2RX5	6	Q93086
CCCKIADKYLLAMTF	SPDYA	91	Q5MJ70
LCVYCCKAYSDKEAK	TCAF2	331	A6NFQ2
CPKCGKCYFRKENLL	ZBTB48	321	P10074
CKYCNKEYLSLGALK	SNAI1	156	O95863
KLYECKECGKALSSL	ZNF823	581	P16415
RKYACKICCKTFLTL	ZBTB5	611	O15062
CKFCGKAFYFLNLCL	ZNF20	201	P17024
SGEKLYLCKACGKAF	ZNF846	361	Q147U1
DKLYECKKCGKIFTC	ZFP30	211	Q9Y2G7
KLYDCKECGKTFFSL	ZNF136	166	P52737
IFACKYKECNKRFLC	RLF	1361	Q13129
ELFSSLKKGKICCCC	SPIRE2	561	Q8WWL2
NYSIVCLKCEKCTYK	USP50	191	Q70EL3
ECKECGKAFKYCSNL	ZNF829	241	Q3KNS6
CDKKDCPKAYHLLCL	NSD3	1336	Q9BZ95
EKAYECTKCGKAFKC	ZNF844	306	Q08AG5
SEKLYDCKDCGKAFC	ZNF404	351	Q494X3
KFYKCEECGKAFKCS	ZNF626	451	Q68DY1
KACECKECGKFFCQK	ZNF25	116	P17030
CKECRKCFYQKSALT	ZNF25	316	P17030
PYKCKLGKACIDFCS	ZNF443	476	Q9Y2A4
YKCKECDKVFGRKCF	ZNF528	381	Q3MIS6
YKCKFCGKALDCLSL	ZNF491	131	Q8N8L2
KAEYNLTACKCLLCK	ZNF800	351	Q2TB10
LTACKCLLCKRKYSS	ZNF800	356	Q2TB10
VKLYKCSECGKCFCR	ZNF12	406	P17014
KCNFCGKALMCLSLY	ZNF625	126	Q96I27
FKCCAYGYRKCLGKK	UGT1A6	506	P19224
SCCSLKCKLLYMDRK	ZFYVE9	731	O95405
CKKCGKAFTKCSYLT	ZNF560	546	Q96MR9
KCEECGKAFKCFSIL	ZNF737	426	O75373
GYIKKCCKGFCIDIL	GRIN2B	451	Q13224