Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dATP binding	ST13P5 ST13	3.33e-05	5	37	2	GO:0032564
GeneOntologyMolecularFunction	adenyl deoxyribonucleotide binding	ST13P5 ST13	4.99e-05	6	37	2	GO:0032558
GeneOntologyMolecularFunction	purine deoxyribonucleotide binding	ST13P5 ST13	6.97e-05	7	37	2	GO:0032554
GeneOntologyMolecularFunction	myosin light chain binding	SPATA6L IQGAP3	9.29e-05	8	37	2	GO:0032027
GeneOntologyMolecularFunction	deoxyribonucleotide binding	ST13P5 ST13	1.19e-04	9	37	2	GO:0032552
GeneOntologyMolecularFunction	unfolded protein binding	ST13P5 ST13 HEATR3	1.63e-03	126	37	3	GO:0051082
GeneOntologyBiologicalProcess	mitotic actomyosin contractile ring assembly	IQGAP3 IQGAP1	9.38e-06	3	37	2	GO:1903475
GeneOntologyBiologicalProcess	mitotic actomyosin contractile ring assembly actin filament organization	IQGAP3 IQGAP1	9.38e-06	3	37	2	GO:1903479
GeneOntologyBiologicalProcess	assembly of actomyosin apparatus involved in mitotic cytokinesis	IQGAP3 IQGAP1	9.38e-06	3	37	2	GO:1902407
GeneOntologyBiologicalProcess	actomyosin contractile ring assembly actin filament organization	IQGAP3 IQGAP1	1.87e-05	4	37	2	GO:2000689
GeneOntologyBiologicalProcess	negative regulation of protein refolding	ST13P5 ST13	3.12e-05	5	37	2	GO:0061084
GeneOntologyBiologicalProcess	regulation of protein refolding	ST13P5 ST13	4.68e-05	6	37	2	GO:0061083
GeneOntologyBiologicalProcess	negative regulation of protein folding	ST13P5 ST13	6.54e-05	7	37	2	GO:1903333
GeneOntologyBiologicalProcess	actomyosin contractile ring assembly	IQGAP3 IQGAP1	1.12e-04	9	37	2	GO:0000915
GeneOntologyBiologicalProcess	assembly of actomyosin apparatus involved in cytokinesis	IQGAP3 IQGAP1	1.12e-04	9	37	2	GO:0000912
GeneOntologyBiologicalProcess	actomyosin contractile ring organization	IQGAP3 IQGAP1	1.40e-04	10	37	2	GO:0044837
GeneOntologyBiologicalProcess	regulation of protein folding	ST13P5 ST13	2.81e-04	14	37	2	GO:1903332
Domain	RasGAP	NF1 IQGAP3 IQGAP1	2.16e-06	14	35	3	SM00323
Domain	RasGAP_CS	NF1 IQGAP3 IQGAP1	2.16e-06	14	35	3	IPR023152
Domain	RAS_GTPASE_ACTIV_2	NF1 IQGAP3 IQGAP1	2.70e-06	15	35	3	PS50018
Domain	RasGAP	NF1 IQGAP3 IQGAP1	2.70e-06	15	35	3	PF00616
Domain	RAS_GTPASE_ACTIV_1	NF1 IQGAP3 IQGAP1	2.70e-06	15	35	3	PS00509
Domain	RasGAP_dom	NF1 IQGAP3 IQGAP1	4.83e-06	18	35	3	IPR001936
Domain	RasGAP_C	IQGAP3 IQGAP1	1.02e-05	3	35	2	IPR000593
Domain	RasGAP_C	IQGAP3 IQGAP1	1.02e-05	3	35	2	PF03836
Domain	Nore1-SARAH	RASSF5 RASSF2	5.09e-05	6	35	2	PF16517
Domain	C-RASSF	RASSF5 RASSF2	5.09e-05	6	35	2	IPR033614
Domain	SARAH	RASSF5 RASSF2	1.22e-04	9	35	2	PS50951
Domain	SARAH_dom	RASSF5 RASSF2	1.22e-04	9	35	2	IPR011524
Domain	STI1_HS-bd	ST13P5 ST13	1.52e-04	10	35	2	IPR006636
Domain	STI1	ST13P5 ST13	1.52e-04	10	35	2	SM00727
Domain	-	IQGAP3 IQGAP1	4.03e-04	16	35	2	1.10.506.10
Domain	Rho_GTPase_activation_prot	NF1 IQGAP3 IQGAP1	5.93e-04	88	35	3	IPR008936
Domain	RA	RASSF5 RASSF2	1.53e-03	31	35	2	SM00314
Domain	TPR	TTC21B ST13P5 ST13	1.79e-03	129	35	3	SM00028
Domain	RA	RASSF5 RASSF2	2.07e-03	36	35	2	PF00788
Domain	RA	RASSF5 RASSF2	2.18e-03	37	35	2	PS50200
Domain	RA_dom	RASSF5 RASSF2	2.54e-03	40	35	2	IPR000159
Domain	TPR-contain_dom	TTC21B ST13P5 ST13	2.75e-03	150	35	3	IPR013026
Domain	TPR	TTC21B ST13P5 ST13	3.60e-03	165	35	3	PS50005
Domain	TPR_REGION	TTC21B ST13P5 ST13	3.60e-03	165	35	3	PS50293
Domain	TPR_8	TTC21B ST13	4.43e-03	53	35	2	PF13181
Domain	CH	IQGAP3 IQGAP1	6.59e-03	65	35	2	SM00033
Domain	CH	IQGAP3 IQGAP1	7.61e-03	70	35	2	PF00307
Domain	IQ	IQGAP3 IQGAP1	7.82e-03	71	35	2	PF00612
Domain	-	IQGAP3 IQGAP1	7.82e-03	71	35	2	1.10.418.10
Domain	CH	IQGAP3 IQGAP1	8.25e-03	73	35	2	PS50021
Domain	CH-domain	IQGAP3 IQGAP1	8.69e-03	75	35	2	IPR001715
Domain	TPR-like_helical_dom	TTC21B ST13P5 ST13	9.35e-03	233	35	3	IPR011990
Domain	IQ	IQGAP3 IQGAP1	1.01e-02	81	35	2	SM00015
Domain	TPR_1	ST13P5 ST13	1.23e-02	90	35	2	PF00515
Domain	TPR_1	ST13P5 ST13	1.23e-02	90	35	2	IPR001440
Domain	IQ_motif_EF-hand-BS	IQGAP3 IQGAP1	1.23e-02	90	35	2	IPR000048
Domain	IQ	IQGAP3 IQGAP1	1.31e-02	93	35	2	PS50096
Pubmed	PPARα Targeting GDF11 Inhibits Vascular Endothelial Cell Senescence in an Atherosclerosis Model.	PPARA GDF11	1.10e-06	2	37	2	33728018
Pubmed	St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis.	ST13P5 ST13	1.10e-06	2	37	2	35562743
Pubmed	Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis.	IQGAP3 IQGAP1	3.30e-06	3	37	2	25229330
Pubmed	The biology of IQGAP proteins: beyond the cytoskeleton.	IQGAP3 IQGAP1	3.30e-06	3	37	2	25722290
Pubmed	Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals.	RASSF5 RASSF2	3.30e-06	3	37	2	17320110
Pubmed	IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.	IQGAP3 IQGAP1	3.30e-06	3	37	2	22493426
Pubmed	Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein.	IQGAP3 IQGAP1	6.60e-06	4	37	2	28970065
Pubmed	Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes.	RASSF5 RASSF2	6.60e-06	4	37	2	15569673
Pubmed	Pharmacological effects of lipid-lowering drugs recapitulate with a larger amplitude the phenotypic effects of common variants within their target genes.	PPARA ATP4B	3.07e-05	8	37	2	18787507
Pubmed	The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1.	RASSF5 RASSF2	3.95e-05	9	37	2	11857081
Pubmed	Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences.	RASSF5 RASSF2	3.95e-05	9	37	2	20920251
Pubmed	Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11.	NCAM1 GDF11	4.93e-05	10	37	2	19297409
Pubmed	Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate.	NCAM1 GDF11	6.02e-05	11	37	2	21852401
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	ANAPC1 IQGAP3 DDX60 IQGAP1	6.28e-05	202	37	4	33005030
Pubmed	IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade.	IQGAP3 IQGAP1	7.22e-05	12	37	2	18604197
Pubmed	Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse.	NCAM1 GDF11	8.53e-05	13	37	2	16267092
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	RASSF5 NF1 INPP5F ANAPC1 RASSF2	1.05e-04	446	37	5	24255178
Pubmed	Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues.	PPARA CYP3A43	1.31e-04	16	37	2	22154759
Pubmed	The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.	IQGAP3 IQGAP1	1.67e-04	18	37	2	19961560
Pubmed	Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.	ST13 IQGAP1	2.07e-04	20	37	2	22504172
Pubmed	Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with Nf1 Knockout in Boundary Cap Cells.	NCAM1 NF1	2.99e-04	24	37	2	30348676
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	TTC21B CDKL3 NF1 ANAPC1	4.15e-04	331	37	4	19490893
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	ST13P5 ST13 HEATR3	5.81e-04	153	37	3	26365490
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	NCAM1 ATP6V1C1 NF1 ST13P5 ST13 IQGAP1 EIF4G2	6.85e-04	1431	37	7	37142655
Pubmed	Impact of lactobacilli on orally acquired listeriosis.	ST13P5 ST13 CYP3A43	6.86e-04	162	37	3	23012479
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	RASSF2 ST13 IQGAP1 EIF4G2	8.35e-04	399	37	4	37536630
GeneFamily	Ras association domain family	RASSF5 RASSF2	5.75e-05	10	21	2	1198
GeneFamily	G protein-coupled receptors, Class A orphans	GPR146 GPR19	3.66e-03	78	21	2	262
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TTC21B ST13	7.78e-03	115	21	2	769
Coexpression	GSE27786_NKTCELL_VS_MONO_MAC_DN	GPR146 RASSF2 GDF11 IQGAP3 IQGAP1	8.79e-06	200	37	5	M4871
ToppCell	droplet-Liver-nan-3m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBH1 RASSF2 DDX60 IQGAP1	3.33e-06	127	36	4	39fa20a55de3af1a62ab5dfa4877879db3935ac2
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	PPARA CNBD2 DDX60 CCDC110	7.71e-06	157	36	4	2c1219ee19a6246a3b9f5c2c1a37f26ea934a822
Disease	Kidney Diseases	TTC21B PPARA	5.47e-03	88	37	2	C0022658
Disease	childhood aggressive behaviour measurement	TTC21B EIF4G2	5.59e-03	89	37	2	EFO_0007663

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLPAFVKKMKLQLAL	TTC21B	211	Q7Z4L5
PLQIRAFAKLLNKKM	ALG11	316	Q2TAA5
FIEKFMPELKAKLLQ	CDKL3	291	Q8IVW4
KVKTIKMFLILNLLF	GPR19	271	Q15760
KPCFIIKMNRIVKFL	ATP4B	176	P51164
NPKVMNLISKLSAKF	ST13P5	351	Q8NFI4
NPKVMNLISKLSAKF	ST13	351	P50502
LAKLIFQMPQNKSTK	IQGAP1	986	P46940
IKFEMPVLKSFIQKL	RASSF2	276	P50749
LKKFMVVDNPQKFAL	RASSF5	306	Q8WWW0
FAELLFKFKQLKMPV	ANAPC1	1911	Q9H1A4
MPQLLKKFSLAKRLQ	KY	101	Q8NBH2
LRKMEKLPALFFLFK	DDX60	1121	Q8IY21
LIIIFILSKFMPKKS	NEMP1	201	O14524
QSPLQKLFARKMKIL	MS4A5	36	Q9H3V2
KQLLLSFKPVMQKFL	EIF4G2	806	P78344
AKLIFQMPQNKTTKF	IQGAP3	971	Q86VI3
LSKPMLFFINVQTKK	MEDAG	111	Q5VYS4
PKMLVNFLAKNKSIS	OR5T1	91	Q8NG75
KKKLNLFKLTPFMVN	FBH1	526	Q8NFZ0
LLSALKEFQPVFKMK	HEATR3	626	Q7Z4Q2
NMKKLLKLDFLDPFL	CYP3A43	206	Q9HB55
ISKKPMNLVLFRFAI	DNAH7	2306	Q8WXX0
FSPKVMFTKVLKAQL	GDF11	166	O95390
QSFPSKLQRLMKKLP	GPR146	301	Q96CH1
FTKPEMKVNFLKPNL	INPP5F	806	Q9Y2H2
FLFPKLLQKMADLRQ	PPARA	421	Q07869
FQAMLLQPNKKTLKK	ATP6V1C1	316	P21283
FPLNTIKMKLKENNL	SPATA6L	161	Q8N4H0
KLRPLIKQMNKNFLL	PGBD1	521	Q96JS3
IPSLRKVKLMFFNKT	CYB5R4	416	Q7L1T6
LMIKAFLPKMLAQKS	BDH2	111	Q9BUT1
ENLNLKSKMKPLIFT	CCDC110	451	Q8TBZ0
EMIKKLLKLNIAFPS	CNBD2	466	Q96M20
NVKIFQKLMFKNAPT	NCAM1	111	P13591
PMLFNKLKNTISKFF	NF1	931	P21359
ALAMSFVLLLPKVNK	MYMK	186	A6NI61