Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glucokinase activity	HK1 HKDC1 GCK	2.21e-06	5	122	3	GO:0004340
GeneOntologyMolecularFunction	hexokinase activity	HK1 HKDC1 GCK	2.21e-06	5	122	3	GO:0004396
GeneOntologyMolecularFunction	fructokinase activity	HK1 HKDC1 GCK	2.21e-06	5	122	3	GO:0008865
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	TRIO IQSEC2 OBSCN ARHGEF15 PLEKHG3 KIAA1755 RIC8A HERC1 RAPGEF2	1.25e-05	231	122	9	GO:0005085
GeneOntologyMolecularFunction	mannokinase activity	HK1 GCK	3.70e-05	2	122	2	GO:0019158
GeneOntologyMolecularFunction	D-glucose binding	HK1 HKDC1 GCK	7.71e-05	14	122	3	GO:0005536
GeneOntologyMolecularFunction	carbohydrate kinase activity	HK1 HKDC1 GCK	2.73e-04	21	122	3	GO:0019200
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	TRIO IQSEC2 OBSCN ARHGEF15 ARHGAP4 CAVIN4 PLEKHG3 KIAA1755 RIC8A HERC1 RAPGEF2	2.82e-04	507	122	11	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	TRIO IQSEC2 OBSCN ARHGEF15 ARHGAP4 CAVIN4 PLEKHG3 KIAA1755 RIC8A HERC1 RAPGEF2	2.82e-04	507	122	11	GO:0030695
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	HK1 MYLK TRIO POLE2 OBSCN HKDC1 GCK RET CCNE1 POLR3B HASPIN PAK3 PKN2 MUSK IPMK	6.01e-04	938	122	15	GO:0016772
GeneOntologyMolecularFunction	kinase activity	HK1 MYLK TRIO OBSCN HKDC1 GCK RET CCNE1 HASPIN PAK3 PKN2 MUSK IPMK	8.05e-04	764	122	13	GO:0016301
GeneOntologyMolecularFunction	PDZ domain binding	GRIK5 CADM1 KIDINS220 RAPGEF2 MUSK	9.54e-04	123	122	5	GO:0030165
GeneOntologyMolecularFunction	enzyme regulator activity	TRIO IQSEC2 OBSCN BIRC6 ARHGEF15 MOB2 CCNE1 ARHGAP4 CAVIN4 KIDINS220 PLEKHG3 CCNE2 FURIN KIAA1755 GMFB RIC8A HERC1 RAPGEF2 RCAN2	9.67e-04	1418	122	19	GO:0030234
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	RAG1 TRIM4 TRIM26 MARCHF6 ZZEF1 BIRC6 TRIM32 LTN1 HERC1 TRIM37	1.19e-03	512	122	10	GO:0019787
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	HK1 MYLK TRIO OBSCN HKDC1 GCK RET HASPIN PAK3 PKN2 MUSK IPMK	1.34e-03	709	122	12	GO:0016773
GeneOntologyMolecularFunction	aminoacyltransferase activity	RAG1 TRIM4 TRIM26 MARCHF6 ZZEF1 BIRC6 TRIM32 LTN1 HERC1 TRIM37	1.59e-03	532	122	10	GO:0016755
GeneOntologyMolecularFunction	myosin binding	RAB3C TRIM32 RAB3A MYBPC3	1.83e-03	85	122	4	GO:0017022
GeneOntologyBiologicalProcess	neuron projection development	TRIO SYNE1 GAS1 OBSL1 LAMA3 RET MOB2 FBXO38 ARHGAP4 NEFL KIDINS220 TRIM32 PAK3 KIAA1755 MACF1 LRRC7 HERC1 RAPGEF2 RAB3A MUSK VPS13B	1.17e-05	1285	118	21	GO:0031175
GeneOntologyBiologicalProcess	regulation of neuron projection development	SYNE1 OBSL1 RET MOB2 FBXO38 ARHGAP4 NEFL KIDINS220 PAK3 MACF1 LRRC7 RAPGEF2 MUSK	4.89e-05	612	118	13	GO:0010975
GeneOntologyBiologicalProcess	neuron development	TRIO SYNE1 GAS1 OBSL1 LAMA3 RET MOB2 FBXO38 ARHGAP4 NEFL KIDINS220 TRIM32 PAK3 KIAA1755 MACF1 LRRC7 HERC1 RAPGEF2 RAB3A MUSK VPS13B	7.86e-05	1463	118	21	GO:0048666
GeneOntologyBiologicalProcess	positive regulation of neuron projection development	RET MOB2 FBXO38 KIDINS220 PAK3 LRRC7 RAPGEF2 MUSK	9.41e-05	249	118	8	GO:0010976
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	TRIO SYNE1 GAS1 OBSL1 LAMA3 RET ARHGAP4 NEFL KIDINS220 PAK3 KIAA1755 MACF1 RAPGEF2 RAB3A	9.61e-05	748	118	14	GO:0048667
GeneOntologyBiologicalProcess	positive regulation of cell projection organization	OBSL1 RET MOB2 FBXO38 NEFL KIDINS220 PAK3 MACF1 LRRC7 RAPGEF2 MUSK	1.27e-04	494	118	11	GO:0031346
GeneOntologyBiologicalProcess	myofibril assembly	FLII OBSCN OBSL1 CAVIN4 MYBPC3	1.35e-04	86	118	5	GO:0030239
GeneOntologyCellularComponent	striated muscle myosin thick filament	OBSCN TRIM32 MYBPC3	7.73e-07	4	122	3	GO:0005863
GeneOntologyCellularComponent	cyclin E1-CDK2 complex	CCNE1 CCNE2	1.01e-04	3	122	2	GO:0097134
Domain	Hexokinase_2	HK1 HKDC1 GCK	2.56e-06	5	120	3	PF03727
Domain	Hexokinase_BS	HK1 HKDC1 GCK	2.56e-06	5	120	3	IPR019807
Domain	Hexokinase_C	HK1 HKDC1 GCK	2.56e-06	5	120	3	IPR022673
Domain	Hexokinase_N	HK1 HKDC1 GCK	2.56e-06	5	120	3	IPR022672
Domain	Hexokinase_1	HK1 HKDC1 GCK	2.56e-06	5	120	3	PF00349
Domain	HEXOKINASE_2	HK1 HKDC1 GCK	2.56e-06	5	120	3	PS51748
Domain	HEXOKINASE_1	HK1 HKDC1 GCK	2.56e-06	5	120	3	PS00378
Domain	Hexokinase	HK1 HKDC1 GCK	5.10e-06	6	120	3	IPR001312
Domain	Cyclin_E	CCNE1 CCNE2	4.09e-05	2	120	2	IPR028858
Domain	Ig_I-set	MYLK TRIO OBSCN OBSL1 CADM1 MUSK MYBPC3	2.28e-04	190	120	7	IPR013098
Domain	I-set	MYLK TRIO OBSCN OBSL1 CADM1 MUSK MYBPC3	2.28e-04	190	120	7	PF07679
Domain	Spectrin	TRIO SYNE1 MACF1	4.17e-04	23	120	3	PF00435
Domain	ConA-like_dom	TRIM4 TRIM26 LAMA3 COL5A3 CELSR1 HERC1 SPRYD4	5.37e-04	219	120	7	IPR013320
Domain	DH_1	TRIO OBSCN ARHGEF15 PLEKHG3	7.21e-04	63	120	4	PS00741
Domain	IGc2	MYLK TRIO OBSCN OBSL1 CADM1 MUSK MYBPC3	8.15e-04	235	120	7	SM00408
Domain	Ig_sub2	MYLK TRIO OBSCN OBSL1 CADM1 MUSK MYBPC3	8.15e-04	235	120	7	IPR003598
Domain	Spectrin_repeat	TRIO SYNE1 MACF1	8.37e-04	29	120	3	IPR002017
Domain	Znf_C3HC4_RING-type	RAG1 TRIM4 TRIM26 MARCHF6 TRIM32 LTN1	8.59e-04	172	120	6	IPR018957
Domain	RhoGEF	TRIO OBSCN ARHGEF15 PLEKHG3	9.61e-04	68	120	4	SM00325
Domain	BBOX	TRIM4 TRIM26 TRIM32 TRIM37	1.02e-03	69	120	4	SM00336
Domain	RhoGEF	TRIO OBSCN ARHGEF15 PLEKHG3	1.07e-03	70	120	4	PF00621
Domain	DH_2	TRIO OBSCN ARHGEF15 PLEKHG3	1.07e-03	70	120	4	PS50010
Domain	SPEC	TRIO SYNE1 MACF1	1.12e-03	32	120	3	SM00150
Domain	Spectrin/alpha-actinin	TRIO SYNE1 MACF1	1.12e-03	32	120	3	IPR018159
Domain	-	TRIO OBSCN ARHGEF15 PLEKHG3	1.13e-03	71	120	4	1.20.900.10
Domain	DH-domain	TRIO OBSCN ARHGEF15 PLEKHG3	1.13e-03	71	120	4	IPR000219
Domain	ZF_BBOX	TRIM4 TRIM26 TRIM32 TRIM37	1.76e-03	80	120	4	PS50119
Domain	Znf_B-box	TRIM4 TRIM26 TRIM32 TRIM37	1.84e-03	81	120	4	IPR000315
Domain	GDS_CDC24_CS	TRIO OBSCN ARHGEF15	2.00e-03	39	120	3	IPR001331
Domain	Laminin_G_2	LAMA3 COL5A3 CELSR1	2.15e-03	40	120	3	PF02210
Domain	SPRY	TRIM4 TRIM26 HERC1 SPRYD4	2.39e-03	87	120	4	SM00449
Domain	LamG	LAMA3 COL5A3 CELSR1	2.83e-03	44	120	3	SM00282
Domain	SPRY	TRIM4 TRIM26 HERC1 SPRYD4	3.17e-03	94	120	4	PF00622
Domain	SPRY_dom	TRIM4 TRIM26 HERC1 SPRYD4	3.17e-03	94	120	4	IPR003877
Domain	zf-C3HC4	RAG1 TRIM4 TRIM26 MARCHF6 TRIM32 LTN1	3.20e-03	223	120	6	PF00097
Domain	B30.2/SPRY	TRIM4 TRIM26 HERC1 SPRYD4	3.29e-03	95	120	4	IPR001870
Domain	B302_SPRY	TRIM4 TRIM26 HERC1 SPRYD4	3.29e-03	95	120	4	PS50188
Domain	Growth_fac_rcpt_	LAMA3 VWCE CELSR1 FURIN FBN3	3.36e-03	156	120	5	IPR009030
Domain	Znf_RING	RAG1 TRIM4 TRIM26 MARCHF6 TRIM32 LTN1 TRIM37	5.13e-03	326	120	7	IPR001841
Domain	Znf_RING-CH	MARCHF6 LTN1	5.23e-03	17	120	2	IPR011016
Domain	RINGv	MARCHF6 LTN1	5.23e-03	17	120	2	SM00744
Domain	Cyclin_C-dom	CCNE1 CCNE2	5.23e-03	17	120	2	IPR004367
Domain	Cyclin_C	CCNE1 CCNE2	5.23e-03	17	120	2	PF02984
Domain	Cyclin_C	CCNE1 CCNE2	5.23e-03	17	120	2	SM01332
Domain	Laminin_G	LAMA3 COL5A3 CELSR1	6.17e-03	58	120	3	IPR001791
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	TRIO SYNE1 IQSEC2 GRIK5 TMEM132B RAB3C NEFL MACF1 LRRC7 RAPGEF2 RAB3A	1.68e-09	251	123	11	27507650
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	FLII TRIO CENPF SYNE1 IQSEC2 MCM3 GRIK5 ARMCX4 TMEM132B RAB3C NEFL HOOK3 WTIP PAK3 MACF1 LRRC7 RAPGEF2 RAB3A	8.95e-09	963	123	18	28671696
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SART3 FLII AARS1 HK1 MCM3 PSMD5 BIRC6 TARDBP RIF1 NOP58 POLR3B TRIM32 PLEKHG3 LTN1 SNX27 MACF1 RIC8A PKN2 MTREX METAP2 GOT2	1.18e-08	1353	123	21	29467282
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	SART3 FLII HK1 CENPF MCM3 PSMD5 GRIK5 BIRC6 TARDBP NOP58 POLR3B LTN1 SNX27 RIC8A MTREX	3.15e-08	704	123	15	29955894
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	TRIO SYNE1 IQSEC2 RAB3C NEFL MACF1 PKN2 LRRC7 RAPGEF2 RAB3A	6.79e-08	281	123	10	28706196
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	MYLK TRIO AFF3 OBSL1 COL5A3 PSMD5 RET RB1CC1 GLCCI1 CCNE1 CCNE2 PAK3 SNX27 PKN2 METAP2 IPMK	1.47e-07	910	123	16	36736316
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FLII AARS1 TRIO VPS39 SYNE1 IQSEC2 OBSL1 PSMD5 ZNF214 ARMCX4 NEFL POLR3B CADM1 TRIM32 MACF1 RAPGEF2 METAP2 TRIM37	6.54e-07	1285	123	18	35914814
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PALD1 FLII HK1 CENPF TRIM26 SYNE1 SELENOH OBSL1 GATB ARMCX4 ZZEF1 BIRC6 ADCY9 NEFL NOP58 MIPEP HERC1 VPS13B SPRYD4	1.34e-06	1496	123	19	32877691
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	BDP1 PALD1 SYNE1 BIRC6 KIDINS220 MACF1	1.87e-06	103	123	6	10574462
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLII CENPF SYNE1 OBSL1 MCM3 RB1CC1 NEFL TARDBP RIF1 NOP58 HOOK3 PLEKHG3 MACF1 MTREX GOT2	3.55e-06	1024	123	15	24711643
Pubmed	Mapping the Genetic Landscape of Human Cells.	BDP1 POLE2 GATB MCM3 NOP58 POLR3B LTN1 BOD1L1 MTREX METAP2	4.95e-06	451	123	10	30033366
Pubmed	Proteomics identifies the developmental regulation of HKDC1 in liver of pigs and mice.	HK1 HKDC1 GCK	5.09e-06	10	123	3	37545422
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	AARS1 HK1 TRIM4 SYNE1 MCM3 COL5A3 PSMD5 ZZEF1 TARDBP NOP58 MACF1 RAB3A GOT2	6.05e-06	807	123	13	30575818
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	RAG1 RET FBXO38 TRIM32 HASPIN GAN PKN2 TRIM37 MUSK	7.50e-06	372	123	9	22939624
Pubmed	E2F4 cooperates with pRB in the development of extra-embryonic tissues.	MCM3 CCNE1 CCNE2	9.28e-06	12	123	3	19433082
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	AARS1 KIAA0930 TRIO IQSEC2 GLCCI1 MOB2 PLEKHG3 GAN MACF1 BOD1L1 MTREX RAPGEF2 MUSK	1.20e-05	861	123	13	36931259
Pubmed	Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse.	NEFL TARDBP	1.24e-05	2	123	2	25457553
Pubmed	Structure and interactions of myosin-binding protein C domain C0: cardiac-specific regulation of myosin at its neck?	MYLK MYBPC3	1.24e-05	2	123	2	21297165
Pubmed	Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.	OBSCN MYBPC3	1.24e-05	2	123	2	19403693
Pubmed	Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin.	CCNE1 CCNE2	1.24e-05	2	123	2	19445941
Pubmed	E-type cyclins modulate telomere integrity in mammalian male meiosis.	CCNE1 CCNE2	1.24e-05	2	123	2	26712234
Pubmed	Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells.	CCNE1 CCNE2	1.24e-05	2	123	2	12970191
Pubmed	Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1.	CCNE1 CCNE2	1.24e-05	2	123	2	23324395
Pubmed	Regulation of cyclin E protein levels through E2F-mediated inhibition of degradation.	CCNE1 CCNE2	1.24e-05	2	123	2	15611651
Pubmed	Which cyclin E prevails as prognostic marker for breast cancer? Results from a retrospective study involving 635 lymph node-negative breast cancer patients.	CCNE1 CCNE2	1.24e-05	2	123	2	16740753
Pubmed	Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene.	LAMA3 GCK	1.24e-05	2	123	2	7665557
Pubmed	Expression of cyclins E1 and E2 during mouse development and in neoplasia.	CCNE1 CCNE2	1.24e-05	2	123	2	11687642
Pubmed	Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells.	CCNE1 CCNE2	1.24e-05	2	123	2	21109536
Pubmed	Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription.	RAG1 ODC1	1.24e-05	2	123	2	36279426
Pubmed	HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma.	RET HOOK3	1.24e-05	2	123	2	17639057
Pubmed	Kinase-independent function of cyclin E.	CCNE1 CCNE2	1.24e-05	2	123	2	17218276
Pubmed	The tripartite motif family identifies cell compartments.	TRIM4 TRIM26 TRIM32 TRIM37	1.36e-05	41	123	4	11331580
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PALD1 SYNE1 OBSL1 KIDINS220 SNX27 MACF1 BOD1L1 LRRC7 VPS13B	1.53e-05	407	123	9	12693553
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	VPS39 SYNE1 OBSL1 BIRC6 ADCY9 ARHGEF15 MACF1	1.62e-05	225	123	7	12168954
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	SART3 TRIM4 VPS39 TRIM26 MCM3 KIDINS220 LTN1 BOD1L1	1.65e-05	313	123	8	38270169
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	SART3 PALD1 AARS1 KIAA0930 IQSEC2 OBSL1 MCM3 XRCC4 GLCCI1 NEFL RIF1 TRIM32 RTL9 SNX27 GAN GID8	1.78e-05	1321	123	16	27173435
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	TRIO SELENOH MCM3 ARHGEF15 MOB2 ARHGAP4 NEFL TARDBP RIF1 NOP58 TRIM32 PLEKHG3 GID8	2.30e-05	916	123	13	32203420
Pubmed	TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.	TRIM26 TRIM32 TRIM37	3.39e-05	18	123	3	23077300
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	IQSEC2 MARCHF6 ADCY9 PLEKHG3 VPS13B	3.71e-05	105	123	5	9628581
Pubmed	De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function.	RAG1 ODC1	3.71e-05	3	123	2	33328226
Pubmed	Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL-/- mice: support for a role for TDP-43 in the physiological response to neuronal injury.	NEFL TARDBP	3.71e-05	3	123	2	19619516
Pubmed	Gas1 reduces Ret tyrosine 1062 phosphorylation and alters GDNF-mediated intracellular signaling.	GAS1 RET	3.71e-05	3	123	2	18394855
Pubmed	Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice.	CCNE1 CCNE2	3.71e-05	3	123	2	23787781
Pubmed	Silencing of long noncoding RNA MYLK-AS1 suppresses nephroblastoma via down-regulation of CCNE1 through transcription factor TCF7L2.	MYLK CCNE1	3.71e-05	3	123	2	33438217
Pubmed	Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation.	KIDINS220 SNX27	3.71e-05	3	123	2	34002021
Pubmed	Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex.	OBSCN OBSL1	3.71e-05	3	123	2	20133654
Pubmed	Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling.	GAS1 RET	3.71e-05	3	123	2	16551639
Pubmed	Dispensable role of protein 4.1B/DAL-1 in rodent adrenal medulla regarding generation of pheochromocytoma and plasmalemmal localization of TSLC1.	RET CADM1	3.71e-05	3	123	2	19321127
Pubmed	Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis.	CCNE1 CCNE2	3.71e-05	3	123	2	21746877
Pubmed	Kinase-independent function of E-type cyclins in liver cancer.	CCNE1 CCNE2	3.71e-05	3	123	2	29339491
Pubmed	Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.	OBSCN OBSL1	3.71e-05	3	123	2	27989621
Pubmed	Motor Neuron and Pancreas Homeobox 1 (MNX1) Is Involved in Promoting Squamous Cervical Cancer Proliferation via Regulating Cyclin E.	CCNE1 CCNE2	3.71e-05	3	123	2	31436258
Pubmed	Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.	SYNE1 MUSK	3.71e-05	3	123	2	10878022
Pubmed	Phosphorylation of MCM3 protein by cyclin E/cyclin-dependent kinase 2 (Cdk2) regulates its function in cell cycle.	MCM3 CCNE1	3.71e-05	3	123	2	21965652
Pubmed	Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.	OBSCN OBSL1	3.71e-05	3	123	2	31098411
Pubmed	Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis.	CCNE1 CCNE2	3.71e-05	3	123	2	24586195
Pubmed	Tumour-suppressive microRNA-144-5p directly targets CCNE1/2 as potential prognostic markers in bladder cancer.	CCNE1 CCNE2	3.71e-05	3	123	2	26057453
Pubmed	T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation.	RAG1 IRF8	3.71e-05	3	123	2	30241692
Pubmed	Amyotrophic lateral sclerosis: Correlations between fluid biomarkers of NfL, TDP-43, and tau, and clinical characteristics.	NEFL TARDBP	3.71e-05	3	123	2	34843548
Pubmed	Role of E2F1-cyclin E1-cyclin E2 circuit in human coronary smooth muscle cell proliferation and therapeutic potential of its downregulation by siRNAs.	CCNE1 CCNE2	3.71e-05	3	123	2	19603101
Pubmed	Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo.	CCNE1 CCNE2	3.71e-05	3	123	2	27828963
Pubmed	Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport.	TARDBP DNMT3A	3.71e-05	3	123	2	25743254
Pubmed	Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin.	OBSCN OBSL1	3.71e-05	3	123	2	20489725
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PALD1 FLII KIAA0930 TRIO VPS39 OBSCN ZZEF1 BIRC6 ADCY9 CCNE1 CELSR1 FURIN RIC8A HERC1	3.81e-05	1105	123	14	35748872
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	SART3 FLII AARS1 HK1 TRIM4 TRIO CENPF SYNE1 MCM3 TARDBP RIF1 NOP58 KIDINS220 BOD1L1 MTREX GOT2	4.42e-05	1425	123	16	30948266
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	TRIM4 OBSL1 RB1CC1 BIRC6 NEFL NOP58 RTL9 HASPIN BOD1L1	4.63e-05	469	123	9	27634302
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SART3 GGNBP2 HK1 MYLK CENPF SYNE1 GATB HKDC1 FAM47B RAB3C NEFL TARDBP MACF1 BOD1L1 RAB3A CFAP46	5.09e-05	1442	123	16	35575683
Pubmed	Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes.	MCM3 CCNE1 CCNE2	5.48e-05	21	123	3	24821722
Pubmed	The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions.	GCK PKN2 MUSK	6.33e-05	22	123	3	24447338
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	PALD1 IRF8 OBSL1 RB1CC1 TARDBP TRIM32 LTN1	6.97e-05	283	123	7	21903422
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	TRIO CENPF SYNE1 MACF1 TRIM37	7.02e-05	120	123	5	31413325
Pubmed	Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases.	CCNE1 CCNE2	7.41e-05	4	123	2	10454565
Pubmed	Loss of Cyclin E1 attenuates hepatitis and hepatocarcinogenesis in a mouse model of chronic liver injury.	CCNE1 CCNE2	7.41e-05	4	123	2	29551768
Pubmed	Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells.	RAB3C RAB3A	7.41e-05	4	123	2	20716109
Pubmed	Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.	MYLK OBSCN	7.41e-05	4	123	2	26147384
Pubmed	Peptide-mediated disruption of calmodulin-cyclin E interactions inhibits proliferation of vascular smooth muscle cells and neointima formation.	CCNE1 CCNE2	7.41e-05	4	123	2	21372285
Pubmed	Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma.	CCNE1 CCNE2	7.41e-05	4	123	2	30150405
Pubmed	Cyclin-dependent kinase control of motile ciliogenesis.	CCNE1 CCNE2	7.41e-05	4	123	2	30152757
Pubmed	SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ-dependent manner.	RAG1 NCOA1	7.41e-05	4	123	2	29282318
Pubmed	Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment.	NEFL GAN	7.41e-05	4	123	2	31944090
Pubmed	Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion.	RAB3C RAB3A	7.41e-05	4	123	2	12167638
Pubmed	Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes.	ODC1 RET	7.41e-05	4	123	2	16138831
Pubmed	A complete genetic analysis of neuronal Rab3 function.	RAB3C RAB3A	7.41e-05	4	123	2	15269275
Pubmed	Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus.	RAG1 GCK	7.41e-05	4	123	2	26752353
Pubmed	T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis.	RAG1 THEMIS	7.41e-05	4	123	2	31932808
Pubmed	Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal alpha -helix motifs.	RAB3C RAB3A	7.41e-05	4	123	2	11431472
Pubmed	Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity.	RAB3C RAB3A	7.41e-05	4	123	2	16436611
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	BDP1 TRIO TRIM26 AFF3 OBSCN LAMA3 OPRL1 KIDINS220 PLEKHG3 PAK3 MACF1 BOD1L1 LRRC7 RAPGEF2 VPS13B RPAP2	7.42e-05	1489	123	16	28611215
Pubmed	Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.	TRIM26 MCM3 XRCC4	9.38e-05	25	123	3	15385968
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	KIAA0930 VPS39 RB1CC1 ADCY9 RIF1 HOOK3 FURIN MIPEP LTN1 SNX27 MACF1 UBIAD1 HERC1	1.02e-04	1061	123	13	33845483
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	SART3 FLII HK1 MCM3 RIF1 NOP58 RIC8A PKN2 MTREX RPAP2	1.14e-04	653	123	10	33742100
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SART3 AARS1 HK1 CENPF BIRC6 NEFL RIF1 NOP58 MACF1 MTREX	1.14e-04	653	123	10	22586326
Pubmed	Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption.	RAB3C RAB3A	1.23e-04	5	123	2	21262767
Pubmed	Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.	RAG1 THEMIS	1.23e-04	5	123	2	19597499
Pubmed	Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm.	CCNE1 CCNE2	1.23e-04	5	123	2	11907280
Pubmed	Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.	HK1 GCK	1.23e-04	5	123	2	19096518
Pubmed	MuSK frizzled-like domain is critical for mammalian neuromuscular junction formation and maintenance.	NEFL MUSK	1.23e-04	5	123	2	25810523
Pubmed	Polyamine metabolism is a central determinant of helper T cell lineage fidelity.	RAG1 ODC1	1.23e-04	5	123	2	34216540
Pubmed	Rab3a is involved in transport of synaptic vesicles to the active zone in mouse brain nerve terminals.	RAB3C RAB3A	1.23e-04	5	123	2	11598194
Pubmed	RET/GFRα signals are dispensable for thymic T cell development in vivo.	RAG1 RET	1.23e-04	5	123	2	23300832
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MYLK TRIO OBSCN OBSL1 MUSK MYBPC3	8.49e-05	161	81	6	593
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIO OBSCN ARHGEF15 PLEKHG3	2.18e-04	66	81	4	722
GeneFamily	Ring finger proteins	RAG1 TRIM4 TRIM26 MARCHF6 TRIM32 LTN1 TRIM37	2.32e-04	275	81	7	58
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM4 TRIM26 TRIM32 TRIM37	8.73e-04	95	81	4	59
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	TRIO CENPF MARCHF6 RB1CC1 XRCC4 ZZEF1 ADCY9 RIF1 KIDINS220 LTN1 NCOA1 MACF1 PKN2 MTREX RAPGEF2 TRIM37 VPS13B	5.45e-07	856	123	17	M4500
Coexpression	GSE37533_PPARG2_FOXP3_VS_FOXP3_TRANSDUCED_CD4_TCELL_PIOGLITAZONE_TREATED_DN	FLII AARS1 SYNE1 IRF8 OBSL1 UBIAD1 MTREX RPAP2	4.51e-06	198	123	8	M8977
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	SART3 CENPF POLE2 MARCHF6 ADCY9 CCNE1 RIF1 RAPGEF2 VPS13B	1.26e-05	300	123	9	M8702
Coexpression	HESS_TARGETS_OF_HOXA9_AND_MEIS1_UP	MYLK MCM3 ODC1 NOP58 METAP2	1.85e-05	69	123	5	M1319
Coexpression	HESS_TARGETS_OF_HOXA9_AND_MEIS1_UP	MYLK MCM3 ODC1 NOP58 METAP2	1.85e-05	69	123	5	MM1158
Coexpression	GEORGES_TARGETS_OF_MIR192_AND_MIR215	USP45 CENPF GATB MCM3 RET GLCCI1 AFAP1L1 CCNE1 TARDBP HOOK3 HASPIN MACF1 GID8 UBIAD1 RPAP2	1.94e-05	892	123	15	M18120
Coexpression	GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN	KLF11 NEU3 FBXO38 HASPIN HERC1 RAPGEF2 DNMT3A	2.33e-05	180	123	7	M6878
Coexpression	GSE27786_NKCELL_VS_NKTCELL_DN	SIKE1 THEMIS HK1 ARMCX4 VWCE CAVIN4 TRIM37	4.42e-05	199	123	7	M4852
Coexpression	STEIN_ESR1_TARGETS	POLE2 RET ADCY9 KIDINS220 CCNE2	4.54e-05	83	123	5	M9678
Coexpression	GSE15330_LYMPHOID_MULTIPOTENT_VS_PRO_BCELL_DN	MCM3 MND1 GLCCI1 NOP58 FURIN NCOA1 MTREX	4.56e-05	200	123	7	M7016
Coexpression	GSE36476_CTRL_VS_TSST_ACT_72H_MEMORY_CD4_TCELL_OLD_DN	AARS1 CENPF POLE2 GATB CCNE1 TRIM32 GOT2	4.56e-05	200	123	7	M5303
Coexpression	EPPERT_PROGENITOR	SART3 POLE2 ODC1 MIPEP MTREX METAP2	4.90e-05	138	123	6	M19232
Coexpression	LEE_BMP2_TARGETS_DN	AARS1 USP45 POLE2 MCM3 PSMD5 ODC1 CCNE1 TARDBP RIF1 NOP58 CCNE2 GMFB MTREX COQ7	9.03e-05	904	123	14	M2325
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP	SART3 AARS1 CENPF POLE2 MCM3 ODC1 CCNE1 RIF1 NOP58 CCNE2 HASPIN	9.06e-05	578	123	11	M2368
Coexpression	MARSON_BOUND_BY_FOXP3_STIMULATED	SART3 GGNBP2 THEMIS MARCHF6 IRF8 GATB MCM3 PSMD5 GCK XRCC4 NOP58 POLR3B HOOK3 HERC1 GOT2	9.29e-05	1024	123	15	M1742
CoexpressionAtlas	alpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3	RAG1 THEMIS CENPF POLE2 MCM3 CCNE1 ARHGAP4 NOP58 CCNE2 TNFRSF8 TRIM37	1.86e-05	397	122	11	GSM791143_500
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c14-MKI67-CCL5_h\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	THEMIS CENPF POLE2 MCM3 MND1 CCNE1 CCNE2 HASPIN	3.91e-08	180	123	8	42f48e646fc6e72ad3cce72409ace3a0b64020a2
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	TRIO AFF3 GLCCI1 ADCY9 CADM1 NCOA1 RAPGEF2 VPS13B	8.16e-08	198	123	8	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CENPF POLE2 LAMA3 MND1 CCNE1 CCNE2 HASPIN	6.76e-07	179	123	7	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE1 LAMA3 MCM3 RIF1 MACF1 BOD1L1 MTREX	1.08e-06	192	123	7	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	Influenza_Severe-T/NK_proliferative\|World / Disease group and Cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2 HASPIN	1.20e-06	195	123	7	6f079c2d7d08110a5e1822ea861b8037eb3f62c9
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RET RIF1 NCOA1 MACF1 BOD1L1 HERC1 DNMT3A	1.20e-06	195	123	7	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RET RIF1 NCOA1 MACF1 BOD1L1 HERC1 DNMT3A	1.20e-06	195	123	7	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	AFF3 GLCCI1 ADCY9 CADM1 NCOA1 RAPGEF2 VPS13B	1.24e-06	196	123	7	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	severe_COVID-19-T/NK_proliferative\|severe_COVID-19 / disease group, cell group and cell class (v2)	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2 HASPIN	1.33e-06	198	123	7	ed86b0247006befe55400c287d334d2202b470bd
ToppCell	COVID-19_Severe-T/NK_proliferative\|World / disease group, cell group and cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2 HASPIN	1.33e-06	198	123	7	48045689d0969ff0a14eee7086b8e19b0d6b6065
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2 HASPIN	1.37e-06	199	123	7	11c3d9fe811a4619347f47d2b0e94066e3085625
ToppCell	mild_COVID-19-T/NK_proliferative\|World / disease group, cell group and cell class (v2)	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2 HASPIN	1.37e-06	199	123	7	d44cc74d7171d96add61dae821daf774b17d4c69
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2 HASPIN	1.37e-06	199	123	7	36c80907b2ec1cbcd1b4e841e6c02a4792591d74
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2 HASPIN	1.37e-06	199	123	7	bf4c31902ae8358215245a2e11b5a2fe4ca1bc8c
ToppCell	COVID-19_Mild-Lymphoid_T/NK-T/NK_proliferative\|COVID-19_Mild / Disease group, lineage and cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2 HASPIN	1.37e-06	199	123	7	ddea0e5c1cb6a096ab8e09a8c3c37c1bff381d9c
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2 HASPIN	1.37e-06	199	123	7	7beb0e07a27fea94674f24eb61c381b0de38ed3e
ToppCell	COVID-19_Mild-T/NK_proliferative\|COVID-19_Mild / Disease condition and Cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2 HASPIN	1.37e-06	199	123	7	9f9a88d2b099646c1e1a7ee3f8d39cb1a2498ad7
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	TRIO AFF3 BIRC6 NCOA1 HERC1 RAPGEF2 VPS13B	1.37e-06	199	123	7	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Influenza_Severe-T/NK_proliferative\|Influenza_Severe / Disease group and Cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2 HASPIN	1.37e-06	199	123	7	2508c55f9ffe17b694c70f1283f41ad4a8e83c00
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	THEMIS CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.42e-06	200	123	7	562309f9ca4a73cea5ed1d85b516891545f3ae5f
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb\|Cerebellum / BrainAtlas - Mouse McCarroll V32	HKDC1 RET CCNE1 TRIM32 LRRC7 MYBPC3	3.68e-06	149	123	6	6e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma-5\|TCGA-Endometrium / Sample_Type by Project: Shred V9	GRIK5 ODC1 CAVIN4 CTCFL FBN3 DNMT3A	4.98e-06	157	123	6	59450e9f580555091b159fbbe0a0756e51bcd9ad
ToppCell	Int-URO-Myeloid-tDC\|Int-URO / Disease, Lineage and Cell Type	PALD1 AARS1 GAS1 IRF8 OBSL1 RAB3C	6.62e-06	165	123	6	9803c3db6cdcf925bea7d9c382bf4fd05acf3509
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CENPF MCM3 MND1 CCNE1 CCNE2 HASPIN	9.89e-06	177	123	6	f925a15d2162d166a5b60edac3517c6b2d6cfbea
ToppCell	severe-multiplets\|severe / disease stage, cell group and cell class	SYNE1 HKDC1 MND1 CCNE1 NEFL GOT2	1.19e-05	183	123	6	78af8df48f0fe49ac37ccec0ad7b2993883b1148
ToppCell	URO-Lymphocyte-T_NK-T_NK_proliferative\|URO / Disease, Lineage and Cell Type	CENPF POLE2 MND1 CCNE1 CCNE2 HASPIN	1.27e-05	185	123	6	0ae9c646679c69a553eda670aef0e0495feb0286
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	MYLK BIRC6 FBXO38 LTN1 BOD1L1 VPS13B	1.31e-05	186	123	6	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	MARCHF6 RB1CC1 BIRC6 MACF1 HERC1 RAPGEF2	1.39e-05	188	123	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Adult / Lineage, Cell type, age group and donor	PALD1 SYNE1 AFF3 OBSCN ARHGEF15 AFAP1L1	1.39e-05	188	123	6	e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RET ABCA8 RAB3C NEFL CADM1 KIAA1755	1.57e-05	192	123	6	3fc7a661ef39286abfd82ed8ab580011f01cb8fd
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	THEMIS SYNE1 COL5A3 GLCCI1 PLEKHG3 MACF1	1.57e-05	192	123	6	ce867b6e78c1d8f30dff81bf572a78a897bc7625
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	THEMIS SYNE1 COL5A3 GLCCI1 PLEKHG3 MACF1	1.57e-05	192	123	6	58a7829b411b02b422ef75e2277a868969cc23e8
ToppCell	Mesenchymal-matrix_fibroblast_2_cell\|World / Lineage, Cell type, age group and donor	GAS1 COL5A3 ABCA8 PAK3 KIAA1755 LRRC7	1.57e-05	192	123	6	a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MND1 OPRL1 WTIP PLEKHG3 RCAN2	1.62e-05	193	123	6	1043b28503bfaa0d5a82ec358bc86cbde73ea8f2
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MND1 OPRL1 WTIP PLEKHG3 RCAN2	1.62e-05	193	123	6	0266a4fdf436d83ec1d9392abba8c6ec5166970a
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CENPF POLE2 MCM3 MND1 CCNE2 HASPIN	1.66e-05	194	123	6	f39a471293ecc5c5967b00e772b8f48ebc9affbe
ToppCell	P03-Endothelial-proliferative_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CENPF SELENOH MCM3 CCNE1 CCNE2 HASPIN	1.66e-05	194	123	6	22bcfb0f3f73608feb22c0847ab4d34f87aeede0
ToppCell	3'_v3-Lung-Myeloid_Mac-Cycling_Myeloid-Mac\|Lung / Manually curated celltypes from each tissue	CENPF POLE2 MCM3 MND1 CCNE1 PIWIL3	1.66e-05	194	123	6	a8ae49157ca3f9e8b3f1750a995aee012dc859b6
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 AFF3 COL5A3 RET GLCCI1 COQ7	1.66e-05	194	123	6	11709704079f24a730476572dc2f01e9d2226e2c
ToppCell	P03-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CENPF SELENOH MCM3 CCNE1 CCNE2 HASPIN	1.66e-05	194	123	6	5e56ce9b9fe0721be3a9e6efe1422599bb867721
ToppCell	3'_v3-blood-Lymphocytic_NK-Cycling_NK\|blood / Manually curated celltypes from each tissue	CENPF POLE2 MCM3 MND1 CCNE2 HASPIN	1.66e-05	194	123	6	bf9734abaad603ade2a6a6940918aaf1e1c4e2cd
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 AFF3 COL5A3 RET GLCCI1 COQ7	1.66e-05	194	123	6	3a1f95639d5f239f001bd67d4213e8938e7f299d
ToppCell	Control-Lymphoid_T/NK-T/NK_proliferative\|Control / Disease group, lineage and cell class	CENPF POLE2 MCM3 MND1 CCNE2 HASPIN	1.66e-05	194	123	6	9bbb124001fba7450f4639f47f9b720a483e7242
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CENPF POLE2 MCM3 MND1 CCNE2 HASPIN	1.66e-05	194	123	6	a75ecd0b0a928d4646602f7d16a645f6b3df3af5
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SYNE1 AFF3 LAMA3 GLCCI1 ADCY9 CADM1	1.66e-05	194	123	6	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CENPF POLE2 MCM3 MND1 CCNE2 HASPIN	1.66e-05	194	123	6	17744fd6645cf5a447a01a83f07e8d305c2bcd9c
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CENPF POLE2 MCM3 MND1 CCNE2 HASPIN	1.66e-05	194	123	6	e14f66f7584909621b776292fbd52808273fd2ee
ToppCell	myeloid-pro-pDC\|myeloid / Lineage and Cell class	MYLK CENPF AFF3 IRF8 MCM3 MND1	1.76e-05	196	123	6	70daf4fabb68aecc5cc9f03d6f6495dd29b74a16
ToppCell	severe_COVID-19-T/NK_proliferative\|World / disease group, cell group and cell class (v2)	CENPF POLE2 MCM3 MND1 CCNE2 HASPIN	1.81e-05	197	123	6	189d97a6c2ff8803db8cc05e205c9d88dac3911f
ToppCell	LPS_IL1RA_TNF\|World / Treatment groups by lineage, cell group, cell type	MYLK SYNE1 LAMA3 ABCA8 PKN2 RCAN2	1.81e-05	197	123	6	0a6550dce156fc81f15b1e7830d331ca50d87d06
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.81e-05	197	123	6	4b13335a43b9d6abc8e542e72440da7feb82fbe6
ToppCell	COVID-19_Severe-T/NK_proliferative\|COVID-19_Severe / Disease condition and Cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.81e-05	197	123	6	718a84e9a8248080f2d964e7c6a3ba183ece9592
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic-lymphocyte-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.81e-05	197	123	6	21861d8b389fafbdb7c3499684c9b6deee3dbd5e
ToppCell	myeloid-pro-pDC\|World / Lineage and Cell class	PALD1 MYLK CENPF IRF8 MCM3 MND1	1.81e-05	197	123	6	8918ee006b16f6b86ed33ce1dd5c0f01f51f88f5
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic-lymphocyte\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.81e-05	197	123	6	ffb004c37cdd26cb7cdcd80f769a2eded65416dc
ToppCell	COVID-19_Moderate-T/NK_proliferative\|COVID-19_Moderate / disease group, cell group and cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.87e-05	198	123	6	166c000fb0e19602ffdd8bf2b2f19be2c6df96a6
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RET RAB3C NEFL CADM1 RAB3A RCAN2	1.87e-05	198	123	6	b58138581f1a9073267d64c1211c5b9b4de71d3e
ToppCell	severe_influenza-T/NK_proliferative\|severe_influenza / disease group, cell group and cell class (v2)	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.92e-05	199	123	6	638b1491c47f2884daf1c1d38a779ad8e0f59c52
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.92e-05	199	123	6	e98ff036d04fc78dffef156bdc0d644532274067
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.92e-05	199	123	6	7feedb0bf84a3361c8ab5b6674ff64e8ff140c23
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	CENPF SYNE1 POLE2 MCM3 MND1 CCNE2	1.92e-05	199	123	6	101f78fe6dd1bf9e2e4dd5ad8a970312b3540927
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-Cycling_B_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IRF8 MCM3 MND1 ODC1 CCNE1 CCNE2	1.92e-05	199	123	6	0cae9c80c15542fd86a82d7b6d6a3ad690cee410
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.92e-05	199	123	6	123fbf2122aa221d8cbf3aef9361ba0982c07695
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CENPF SYNE1 POLE2 MCM3 MND1 CCNE2	1.92e-05	199	123	6	e0fcec796afe75e42467ca86355b9fc5aa9ae0a1
ToppCell	COVID-19_Severe-Lymphoid_T/NK-T/NK_proliferative\|COVID-19_Severe / Disease group, lineage and cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.92e-05	199	123	6	ddae7fe7633661f15d3c79f5187415ffbfecce67
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.92e-05	199	123	6	6b1304417cf9c44ca70d2bfc2b5acc1a206f25b6
ToppCell	mild_COVID-19-T/NK_proliferative\|mild_COVID-19 / disease group, cell group and cell class (v2)	CENPF POLE2 MCM3 MND1 CCNE2 HASPIN	1.92e-05	199	123	6	df2fcaf01b1b48632f84e7355ef21d20853f0664
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Stem_cells\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	CENPF MCM3 MND1 GLCCI1 CELSR1 CCNE2	1.97e-05	200	123	6	4c22a1f35ff496fa6af2ab171f2936785272bc06
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-T/NK_proliferative\|COVID-19_Mild / Disease, condition lineage and cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.97e-05	200	123	6	6126a3bbafe2110fba0c1c4493035df4e8193d22
ToppCell	severe-T/NK_proliferative\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.97e-05	200	123	6	9d6e7e2d6cfa8c96bbb5c187815df96ecaa5475c
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-T/NK_proliferative\|COVID-19_Severe / Disease, condition lineage and cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.97e-05	200	123	6	0892603e604c2a945dd720685d45970f855bd5d3
ToppCell	control-T/NK_proliferative\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.97e-05	200	123	6	1da366e35a05f73253629663eeea1fed4ebd7b52
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	BDP1 SYNE1 AFF3 PAK3 LRRC7 HERC1	1.97e-05	200	123	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	mild-T/NK_proliferative\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.97e-05	200	123	6	25b4a1a33348e274bd4457efc0d6faa5421c3d31
ToppCell	PSB-critical-LOC-Lymphoid-Treg\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CENPF POLE2 MND1 CCNE1 CCNE2 HASPIN	1.97e-05	200	123	6	3e3de496508efb2f95e5e8684f97687381e96493
ToppCell	severe-T/NK_proliferative\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.97e-05	200	123	6	d341f4e500377a5bef82c24bf64704b981053336
ToppCell	356C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CENPF MCM3 MND1 CCNE1 CCNE2 HASPIN	1.97e-05	200	123	6	2afbb5b5742b956993796621fea7e0c9888754a1
ToppCell	Sepsis-Int-URO-Myeloid-tDC\|Int-URO / Disease, condition lineage and cell class	PALD1 AARS1 GAS1 IRF8 OBSL1 RAB3C	1.97e-05	200	123	6	f5d0497a72da21cad24e0ef51c3dc4d024dbf294
ToppCell	356C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CENPF MCM3 MND1 CCNE1 CCNE2 HASPIN	1.97e-05	200	123	6	4462ebd5d4632788f10a93fadd2babae701c754f
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CENPF POLE2 MCM3 MND1 NEFL CCNE2	1.97e-05	200	123	6	af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCell	Influenza-Influenza_Severe-Lymphocyte-T/NK-T/NK_proliferative\|Influenza_Severe / Disease, condition lineage and cell class	CENPF POLE2 MCM3 MND1 CCNE1 CCNE2	1.97e-05	200	123	6	e1c266525ce6b42a4451b6a3b0cabf41ff5e2ee7
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Stem_cells-Neuroepithelial_cell\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	CENPF MCM3 MND1 GLCCI1 CELSR1 CCNE2	1.97e-05	200	123	6	0632b8d3a1be437f146bc86aae9646303e37a0bd
ToppCell	droplet-Lung-30m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l33\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GGNBP2 COL5A3 ARMCX4 CADM1 RAPGEF2	3.80e-05	136	123	5	a43b3db1754c619d328a26a2ba6af4756629a723
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|367C / Donor, Lineage, Cell class and subclass (all cells)	BDP1 MCM3 ZZEF1 GAN RPAP2	5.88e-05	149	123	5	41f28138bde45d0b814e116837e5a32b5e80d54a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 GAS1 COL5A3 GCK WTIP	6.07e-05	150	123	5	8645b9c7f9511ed6cc9afe04440c2873a3094150
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Pro-B\|bone_marrow / Manually curated celltypes from each tissue	PALD1 RAG1 MYLK AFF3 GCK	7.30e-05	156	123	5	b093dbba6662e4fffc8aa577587b77f64ac44b56
ToppCell	facs-Heart-RV-24m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAVIN4 COQ7 RCAN2 CFAP46 MYBPC3	7.76e-05	158	123	5	2ef43d14ee65d004dc62c12ff209bbe12e4db681
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMEM132B ABCA8 CADM1 KIAA1755 LRRC7	8.73e-05	162	123	5	d28b2ea1d2c8f3c6a107991573471b6d0c49c4ae
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMEM132B ABCA8 CADM1 KIAA1755 LRRC7	8.73e-05	162	123	5	5bbd7130d4dad9035e73a439dda568195c136f31
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMEM132B ABCA8 CADM1 KIAA1755 LRRC7	8.73e-05	162	123	5	eed223e61c8162a2fe004ab4e09de5e037be7553
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMEM132B ABCA8 CADM1 KIAA1755 LRRC7	8.73e-05	162	123	5	e35ddce830e20ebeac1a2c405293fc4a5323dd4a
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PALD1 CENPF MCM3 ARHGEF15 CCNE2	8.98e-05	163	123	5	3efbbdc9cb2613bb76d8c2f07cd4ec1a2c51a622
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CENPF POLE2 LAMA3 MND1 CCNE1	9.52e-05	165	123	5	88681101d7cf60b99b8ace5d8c0944323b937306
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	POLE2 LAMA3 MND1 CCNE1 CCNE2	1.01e-04	167	123	5	108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCell	Children_(3_yrs)-Mesenchymal-chondrocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MYLK WTIP UBIAD1 MUSK CFAP46	1.01e-04	167	123	5	f4943fb5001475ddab82a0273bcbb3fa68fdd7bd
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THEMIS SELENOH AMDHD1 MCM3 NOP58	1.04e-04	168	123	5	ade02beb8d663fce4be2aefa10392ab849a4bbe7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CENPF POLE2 LAMA3 MND1 CCNE1	1.06e-04	169	123	5	0bc8ef341ce307b19018d4ac8de0a4d04254209d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	POLE2 LAMA3 MCM3 MND1 CCNE2	1.06e-04	169	123	5	121768fc51fc3441ec725346a1bbe29e21d05971
ToppCell	metastatic_Lymph_Node-T/NK_cells-Exhausted_Tfh\|metastatic_Lymph_Node / Location, Cell class and cell subclass	THEMIS PRDM11 TNFRSF8 FURIN HASPIN	1.06e-04	169	123	5	ad9054ee09033b648a76baf1b2ec4a6ab1394bde
ToppCell	COVID-19_Convalescent-cDC\|COVID-19_Convalescent / Disease condition and Cell class	CENPF AFF3 HKDC1 MCM3 MND1	1.13e-04	171	123	5	9ccaa9f1629818b0f63a5d930ee78c01e04cd98d
Disease	Malignant neoplasm of breast	CENPF VPS39 SYNE1 OBSCN IRF8 RB1CC1 CCNE1 RIF1 CADM1 HOOK3 NCOA1 MACF1 BOD1L1 RIC8A LRRC7 VPS13B DNMT3A	1.91e-06	1074	121	17	C0006142
Disease	serum albumin measurement	TRIM26 GRIK5 ZZEF1 ABCA8 ADCY9 TARDBP RTL9 MIPEP MACF1 TSKS SPRYD4 MYBPC3	6.11e-06	592	121	12	EFO_0004535
Disease	Intellectual Disability	HK1 TRIO SYNE1 AFF3 ODC1 POLR3B SNX27 MACF1 GOT2 DNMT3A	1.63e-05	447	121	10	C3714756
Disease	Seckel syndrome	CENPF XRCC4 DNMT3A	9.78e-05	22	121	3	C0265202
Disease	Smith-Magenis syndrome	FLII IQSEC2	9.95e-05	4	121	2	C0795864
Disease	amyloid-beta measurement	AFF3 GAS1 GRIK5 TMEM132B MROH2B NCOA1 GAN UBIAD1	1.12e-04	355	121	8	EFO_0005194
Disease	chordin-like protein 1 measurement	RTL9 PAK3	1.65e-04	5	121	2	EFO_0020257
Disease	hyperinsulinemic hypoglycemia (implicated_via_orthology)	HKDC1 GCK	1.65e-04	5	121	2	DOID:13317 (implicated_via_orthology)
Disease	glucose metabolism disease (implicated_via_orthology)	HK1 HKDC1 GCK	2.04e-04	28	121	3	DOID:4194 (implicated_via_orthology)
Disease	amyotrophic lateral sclerosis (is_marker_for)	NEFL TARDBP MTREX	2.27e-04	29	121	3	DOID:332 (is_marker_for)
Disease	glucagon measurement, glucose tolerance test	MACF1 HERC1	2.47e-04	6	121	2	EFO_0004307, EFO_0008463
Disease	cardiac troponin T measurement	TRIO RB1CC1 XRCC4 TARDBP CELSR1 IPMK	2.95e-04	219	121	6	EFO_0005043
Disease	Mammary Carcinoma, Human	CENPF VPS39 SYNE1 RB1CC1 CCNE1 CADM1 NCOA1 RIC8A DNMT3A	3.24e-04	525	121	9	C4704874
Disease	Mammary Neoplasms, Human	CENPF VPS39 SYNE1 RB1CC1 CCNE1 CADM1 NCOA1 RIC8A DNMT3A	3.24e-04	525	121	9	C1257931
Disease	Mammary Neoplasms	CENPF VPS39 SYNE1 RB1CC1 CCNE1 CADM1 NCOA1 RIC8A DNMT3A	3.33e-04	527	121	9	C1458155
Disease	level of oxylipin in blood plasma	GRIK5 KIAA1755	3.46e-04	7	121	2	OBA_2050338
Disease	Breast Carcinoma	CENPF VPS39 SYNE1 RB1CC1 CCNE1 CADM1 NCOA1 RIC8A DNMT3A	3.87e-04	538	121	9	C0678222
Disease	neuroimaging measurement	AFF3 GAS1 XRCC4 GLCCI1 AFAP1L1 NEFL CELSR1 FURIN KIAA1755 MACF1 RAPGEF2 METAP2 MUSK	4.55e-04	1069	121	13	EFO_0004346
Disease	vital capacity	SYNE1 AFF3 HKDC1 ZKSCAN2 ZZEF1 AFAP1L1 OPRL1 CAVIN4 PRDM11 RTL9 NCOA1 METAP2 MUSK FBN3	5.53e-04	1236	121	14	EFO_0004312
Disease	Charcot-Marie-Tooth disease	AARS1 HK1 NEFL	6.87e-04	42	121	3	cv:C0007959
Disease	glutamine measurement	AARS1 CTCFL MIPEP SPRYD4	6.95e-04	97	121	4	EFO_0009768
Disease	maturity-onset diabetes of the young (implicated_via_orthology)	HKDC1 GCK	7.35e-04	10	121	2	DOID:0050524 (implicated_via_orthology)
Disease	glutamine measurement, amino acid measurement	MIPEP SPRYD4	8.95e-04	11	121	2	EFO_0005134, EFO_0009768
Disease	quality of life during menstruation measurement, dysmenorrheic pain measurement	RB1CC1 VPS13B	8.95e-04	11	121	2	EFO_0007889, EFO_0009366
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 HOOK3	1.07e-03	12	121	2	DOID:11726 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease (is_implicated_in)	NEFL POLR3B	1.07e-03	12	121	2	DOID:10595 (is_implicated_in)
Disease	Alzheimer disease, dementia	POLR3B CFAP46	1.07e-03	12	121	2	MONDO_0001627, MONDO_0004975
Disease	body mass index, fasting blood glucose measurement	GCK ADCY9 MUSK	1.21e-03	51	121	3	EFO_0004340, EFO_0004465
Disease	skin and soft tissue Staphylococcus aureus infection	GAN METAP2	1.26e-03	13	121	2	EFO_1001489
Disease	retinal vasculature measurement	HK1 TRIO AFF3 RB1CC1 GLCCI1 POLR3B PLEKHG3 METAP2	1.35e-03	517	121	8	EFO_0010554
Disease	unipolar depression, anxiety	ZKSCAN2 LRRC7	1.47e-03	14	121	2	EFO_0003761, EFO_0005230
Disease	Maturity onset diabetes mellitus in young	KLF11 GCK	1.47e-03	14	121	2	C0342276
Disease	isoleucine measurement	AARS1 MIPEP SPRYD4	1.59e-03	56	121	3	EFO_0009793
Disease	multiple myeloma (is_implicated_in)	HK1 IRF8 XRCC4	1.85e-03	59	121	3	DOID:9538 (is_implicated_in)
Disease	Monogenic diabetes	KLF11 GCK	1.93e-03	16	121	2	C3888631
Disease	verbal-numerical reasoning measurement	GGNBP2 GATB BIRC6 FBN3	2.11e-03	131	121	4	EFO_0008394
Disease	chronic obstructive pulmonary disease	CYP2B6 TRIM26 AFF3 MCM3 AFAP1L1 FBXO38 PRDM11 CADM1 DNMT3A	2.16e-03	688	121	9	EFO_0000341
Disease	muscular dystrophy (is_implicated_in)	SYNE1 TRIM32	2.18e-03	17	121	2	DOID:9884 (is_implicated_in)
Disease	eicosapentaenoate EPA; 20:5n3 measurement	GRIK5 MUSK	2.18e-03	17	121	2	EFO_0021049
Disease	hyperglycemia (implicated_via_orthology)	HKDC1 GCK	2.18e-03	17	121	2	DOID:4195 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease type 2	AARS1 NEFL	2.18e-03	17	121	2	cv:C0270914
Disease	Global developmental delay	HK1 ODC1 SNX27 GOT2	2.23e-03	133	121	4	C0557874
Disease	histidine measurement	AMDHD1 MIPEP SPRYD4	2.55e-03	66	121	3	EFO_0009769
Disease	Microcephaly	CENPF GOT2 DNMT3A	2.66e-03	67	121	3	C0025958
Disease	Lewy body dementia (is_marker_for)	NEFL TARDBP	2.72e-03	19	121	2	DOID:12217 (is_marker_for)
Disease	Chronic myeloproliferative disorder	CENPF XRCC4	2.72e-03	19	121	2	C1292778
Disease	monocyte percentage of leukocytes	IQSEC2 IRF8 GLCCI1 ADCY9 CCNE1 NCOA1 KIAA1755 MUSK IPMK	3.22e-03	731	121	9	EFO_0007989
Disease	neuritic plaque measurement	CYP2B6 TRIO GRIK5 MROH2B GAN GOT2	3.23e-03	349	121	6	EFO_0006798
Disease	type 1 diabetes mellitus	PALD1 AFF3 NCOA1 MUSK RPAP2	3.27e-03	242	121	5	MONDO_0005147
Disease	albumin:globulin ratio measurement	AFF3 ARHGAP4 MUSK	3.39e-03	73	121	3	EFO_0005128
Disease	leucine measurement	AARS1 RB1CC1 SPRYD4	3.39e-03	73	121	3	EFO_0009770
Disease	gamma-glutamylglutamine measurement	MIPEP SPRYD4	3.65e-03	22	121	2	EFO_0021138
Disease	fat intake measurement	NCOA1 DNMT3A	3.65e-03	22	121	2	EFO_0010809
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	PALD1 GGNBP2 ZZEF1 ADCY9 CCNE1 MACF1	3.96e-03	364	121	6	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	BMI-adjusted fasting blood glucose measurement	GCK MUSK	3.99e-03	23	121	2	EFO_0008036
Disease	phosphatidylserines measurement	GRIK5 MUSK	3.99e-03	23	121	2	EFO_0020049

Protein segments in the cluster

Peptide	Gene	Start	Entry
GETNSCVEEIIREMT	AFF3	296	P51826
CVTKGAEMETQRETE	BDP1	2126	A6H8Y1
VMLCGVEAIREALVD	CYP2B6	76	P20813
EVCRATTGAEETLMH	BIRC6	4826	Q9NR09
EEVDEGVTCEMLLNT	CTCFL	646	Q8NI51
IASEVCEDSITVGMV	DNMT3A	661	Q9Y6K1
VTDGACSGDEILTME	CCNE1	216	P24864
GACSEEDILRMELII	CCNE2	216	O96020
VAAAASLEMVECVGT	CFAP46	2061	Q8IYW2
MIERSVVEAAVQECS	POLE2	61	P56282
EGCERVKVFEEMASR	GLCCI1	421	Q86VQ1
MSCGEEAATAVRELQ	GATB	226	O75879
ERCSAEVGRMKQTEE	ARHGEF15	596	O94989
GEKMAVVTVDDCDTT	CELSR1	1551	Q9NYQ6
RMTGVTCDDVNECES	FBN3	861	Q75N90
TVAEGEECAREMGVD	CAVIN4	281	Q5BKX8
EECAREMGVDIIARS	CAVIN4	286	Q5BKX8
SGAGEEAMICSRIEA	ARMCX4	1771	Q5H9R4
MDCDVSTLVACVVDV	RCAN2	6	Q14206
VVVKESCDGMGDVSE	RAG1	596	P15918
KCDMEDERVVSSERG	RAB3A	136	P20336
VGNKCDMEDERVIST	RAB3C	141	Q96E17
VELVEGDEGRMCVNT	GCK	241	P35557
MVEEVDRAITACAEL	PALD1	371	Q9ULE6
EFGTMCTERDTETVK	LTN1	86	O94822
ETAIMDDLTEVLCSG	MOB2	196	Q70IA6
TSECVMLACEVDRED	OBSL1	821	O75147
VETADEGRVDSAMET	RB1CC1	1426	Q8TDY2
SMGTEVSEEDICNIL	NOP58	241	Q9Y2X3
TDVVTETCMDEGQIA	PAK3	366	O75914
ETCMDEGQIAAVCRE	PAK3	371	O75914
EMIATLSDACEREFG	KIDINS220	616	Q9ULH0
ATCTAELIVETMEEG	MYLK	1891	Q15746
CRTVREEMGDESEEF	FLII	576	Q13045
RLCDVGEAIQEVMES	METAP2	296	P50579
EANMAVTRDDDVLCV	LAMA3	201	Q16787
MSQECRDEVVLIDSS	GGNBP2	186	Q9H3C7
RIETVDMDISGCEAL	LRRC7	241	Q96NW7
VEQARCGEVAFRMDE	KIAA1755	251	Q5JYT7
CGEVAFRMDEVVSQD	KIAA1755	256	Q5JYT7
RDVLDCVVDEMDFSS	IQSEC2	816	Q5JU85
DCASSPVVHEDVEMR	HERC1	2546	Q15751
GVFDDTITEMCQELE	HERC1	4526	Q15751
TITEMCQELETGIVD	HERC1	4531	Q15751
EGEMVCVELVASDKT	KIAA0930	181	Q6ICG6
NEVTEMECGRSEIDE	IRF8	131	Q02556
LQSLVDDGMVDCERI	MND1	51	Q9BWT6
RARCEGQEMTTEELT	FAM47B	361	Q8NA70
EDNCIMEEGVLSLVE	LRRC74A	141	Q0VAA2
MDTAEEDICRVCRSE	MARCHF6	1	O60337
GLRCTDECRTVIEDM	GAS1	196	P54826
MFSVESLERAELCES	HOOK3	1	Q86VS8
DLVEGDEGRMCINTE	HK1	246	P19367
TGCQEIAEVEVRMID	IPMK	371	Q8NFU5
CESLTTEEVINEGLM	MACF1	2346	Q9UPN3
AVRVGDTAMFCVELA	OBSCN	431	Q5VST9
GAMVLADRGVVCIDE	MCM3	396	P25205
LSADICMETIGEEIS	FBXO38	1141	Q6PIJ6
EEKDECAMISTSIGE	BOD1L1	2136	Q8NFC6
CEAVMIGAVLQDEDR	BOD1L1	2301	Q8NFC6
GDIMVTVSSEENVCD	BOD1L1	2636	Q8NFC6
AVEGEEIEVNCTAMA	CADM1	156	Q9BY67
VDRGMQVLAACFTEE	SDR9C7	46	Q8NEX9
SECITATRKMAEEVG	CENPF	1326	P49454
MLDGEVTDAVEARSL	FURIN	226	P09958
VRSREDAQGSEMVTC	GAN	476	Q9H2C0
KEGAMACTVAVEESI	COQ7	131	Q99807
EQGEESRECLTEMER	GID8	131	Q9NWU2
RMDTTGVECRIQVSE	ADCY9	1196	O60503
EVSDEGIVAMATARC	AMDHD1	286	Q96NU7
DGIVVFCDVSMDEDL	HASPIN	696	Q8TF76
DARAVDIMDICESIL	KLF11	11	O14901
RRSAESEEVSVCQEM	GRIK5	831	Q16478
VETDVQRTMFVGIDC	PIWIL3	641	Q7Z3Z3
CEVLLTMERTEGSLE	SART3	546	Q15020
AVSIDGEMVTLVADC	COL5A3	151	P25940
AISDARCVFDMGAEV	ODC1	211	P11926
AIMGSAQVEDEEIEC	OPRL1	186	P41146
MSESLVVCDVAEDLV	GMFB	1	P60983
EAARGSCSVEEEMEI	RTL9	1156	Q8NET4
MCVDARGDLIVADSS	TRIM32	581	Q13049
MDEQSVESIAEVFRC	TRIM37	1	O94972
RIGVADVDMSRDSCI	SPRYD4	101	Q8WW59
DVDMSRDSCIGVDDR	SPRYD4	106	Q8WW59
AIGETVTECESRMVQ	SYNE1	4871	Q8NF91
EECTTMIDRGLQFEE	TMEM132B	966	Q14DG7
RKVFVGRCTEDMTED	TARDBP	191	Q13148
DLVEGDEGRMCINTE	HKDC1	246	Q2TB90
DCEGEDVVDMLREAI	HKDC1	626	Q2TB90
GFEVVEDAIDTMTCV	PLEKHG3	251	A1L390
FVCDTVEMSTEEGII	RIF1	2066	Q5UIP0
CETDRMDGAVTSVTI	NCOA1	831	Q15788
MEVVKDTSGESDVRC	PRDM11	151	Q9NQV5
AEIESQIDRICEMGE	SIKE1	136	Q9BRV8
GDIVARDEVDSLMCE	PKN2	691	Q16513
DDIARVEAISVACAM	MROH2B	1131	Q7Z745
RHCVMIATAGDRTEE	RIC8A	256	Q9NPQ8
NEFTVGEECELETMT	FABP1	61	P07148
DGDEVAEICVEMELR	ARHGAP4	341	P98171
AEAVCDRVAIMVSGR	ABCA8	1481	O94911
ERVGAFTMVCKDADE	GOT2	286	P00505
RQEVAILEASCSEDM	AFAP1L1	486	Q8TED9
AVIMDEDCRSTDEIR	C12orf40	241	Q86WS4
RCDAGIQTESESVME	C12orf40	591	Q86WS4
MVTVECEVAEVTGRA	NEU3	221	Q9UQ49
ELCAVMVFAVVERAG	RAPGEF2	146	Q9Y4G8
VEEIDGEIMVSCAVA	THEMIS	141	Q8N1K5
DRIFIGELTSTVMCE	USP45	351	Q70EL2
EAAEEACRSIGTMVE	MIPEP	136	Q99797
EMKGRVACEISSADE	MTREX	871	P42285
REKMFVEEVSTGQEC	AARS1	511	P49588
LEENITEEFLMECGR	RPAP2	66	Q8IXW5
MEEATVVIEHCTSUR	SELENOH	31	Q8IZQ5
QEGETAICSEMTADR	XRCC4	211	Q13426
MTETAVGIRCTDIDE	VWCE	131	Q96DN2
SCSDVMLSVEEEGKE	TNFRSF8	571	P28908
VCSIRVIGESDIMQE	SNX27	246	Q96L92
ERLMISSDAFEVDVC	POLR3B	1066	Q9NW08
DELCTMVERSAVSVA	TSKS	391	Q9UJT2
EEVLESCMVGVARDS	TRIM26	431	Q12899
DMESDREAGIVTLAI	UBIAD1	236	Q9Y5Z9
AVCTVHAGAREEVVM	RET	241	P07949
GTEVCMVSELEDLSA	VPS13B	1346	Q7Z7G8
AVMDTLVSVAARECE	ZZEF1	931	O43149
EDSCSERMSEEEIVQ	ZKSCAN2	631	Q63HK3
LTGEDVLVRATCIEM	PSMD5	216	Q16401
QGCETTIRVVSMDRD	WTIP	361	A6NIX2
EVAVGVCREDVMGIT	TRIM4	391	Q9C037
VGVICQEDLLRDSME	ZNF214	201	Q9UL59
ASGVELLCDRDVDMA	TRIO	861	O75962
HTETGEEVLRMCVAV	VPS39	126	Q96JC1
TVDALVEEVATFMCA	MUSK	36	O15146
MVGQRVEFECEVSEE	MYBPC3	466	Q14896
TLEIEACRGMNEALE	NEFL	316	P07196