Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR2	5.11e-05	3	83	2	GO:0005220
GeneOntologyMolecularFunction	calcium ion binding	EFCAB5 FAT2 CDH22 NKD2 HMCN1 PCDHGC4 DCHS1 C1R IHH PCDH8 ITPR1 ITPR2	5.98e-05	749	83	12	GO:0005509
GeneOntologyMolecularFunction	structural constituent of cytoskeleton	TUBA3D SPTBN2 TUBA3E TUBA3C PPL	2.09e-04	130	83	5	GO:0005200
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	FAT2 CDH22 HMCN1 PCDHGC4 DCHS1 ROBO1 PCDH8	1.04e-05	187	83	7	GO:0007156
GeneOntologyCellularComponent	extrinsic component of plasma membrane	CDH22 AKAP9 PLEKHA4 DCHS1 PPL	2.05e-04	137	82	5	GO:0019897
GeneOntologyCellularComponent	platelet dense tubular network membrane	ITPR1 ITPR2	5.38e-04	9	82	2	GO:0031095
GeneOntologyCellularComponent	platelet dense tubular network	ITPR1 ITPR2	8.17e-04	11	82	2	GO:0031094
GeneOntologyCellularComponent	photoreceptor connecting cilium	WHRN IFT140 KIAA1549	8.86e-04	48	82	3	GO:0032391
GeneOntologyCellularComponent	cell body	WHRN AKAP9 DISC1 SPTBN2 ENTPD1 MAST1 ROBO1 GRIN3A CHRNA3 TIAM2 ITPR1	9.84e-04	929	82	11	GO:0044297
GeneOntologyCellularComponent	ciliary basal body	WHRN IFT140 AKAP9 DISC1 PKHD1	1.02e-03	195	82	5	GO:0036064
Domain	InsP3_rcpt-bd	ITPR1 ITPR2	5.42e-05	3	80	2	IPR000493
Domain	Cadherin_CS	FAT2 CDH22 PCDHGC4 DCHS1 PCDH8	1.05e-04	109	80	5	IPR020894
Domain	CADHERIN_1	FAT2 CDH22 PCDHGC4 DCHS1 PCDH8	1.24e-04	113	80	5	PS00232
Domain	Cadherin	FAT2 CDH22 PCDHGC4 DCHS1 PCDH8	1.24e-04	113	80	5	PF00028
Domain	CADHERIN_2	FAT2 CDH22 PCDHGC4 DCHS1 PCDH8	1.30e-04	114	80	5	PS50268
Domain	-	FAT2 CDH22 PCDHGC4 DCHS1 PCDH8	1.30e-04	114	80	5	2.60.40.60
Domain	CA	FAT2 CDH22 PCDHGC4 DCHS1 PCDH8	1.35e-04	115	80	5	SM00112
Domain	Cadherin-like	FAT2 CDH22 PCDHGC4 DCHS1 PCDH8	1.41e-04	116	80	5	IPR015919
Domain	Cadherin	FAT2 CDH22 PCDHGC4 DCHS1 PCDH8	1.52e-04	118	80	5	IPR002126
Domain	RIH_assoc	ITPR1 ITPR2	2.69e-04	6	80	2	PF08454
Domain	RIH_assoc-dom	ITPR1 ITPR2	2.69e-04	6	80	2	IPR013662
Domain	RIH_dom	ITPR1 ITPR2	2.69e-04	6	80	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR1 ITPR2	2.69e-04	6	80	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR1 ITPR2	2.69e-04	6	80	2	IPR015925
Domain	-	ITPR1 ITPR2	2.69e-04	6	80	2	1.25.10.30
Domain	RYDR_ITPR	ITPR1 ITPR2	2.69e-04	6	80	2	PF01365
Domain	Ins145_P3_rec	ITPR1 ITPR2	2.69e-04	6	80	2	PF08709
Domain	Alpha_tubulin	TUBA3D TUBA3E	6.40e-04	9	80	2	IPR002452
Domain	MIR	ITPR1 ITPR2	7.97e-04	10	80	2	PS50919
Domain	MIR	ITPR1 ITPR2	7.97e-04	10	80	2	PF02815
Domain	MIR	ITPR1 ITPR2	7.97e-04	10	80	2	SM00472
Domain	MIR_motif	ITPR1 ITPR2	7.97e-04	10	80	2	IPR016093
Domain	CH	SPTBN2 PARVA IQGAP3	2.73e-03	65	80	3	SM00033
Domain	PDZ	WHRN MAST1 SIPA1L2 TIAM2	3.16e-03	141	80	4	PF00595
Domain	-	TUBA3D TUBA3E	3.27e-03	20	80	2	3.30.1330.20
Domain	CH	SPTBN2 PARVA IQGAP3	3.37e-03	70	80	3	PF00307
Domain	-	SPTBN2 PARVA IQGAP3	3.51e-03	71	80	3	1.10.418.10
Domain	-	TUBA3D TUBA3E	3.61e-03	21	80	2	1.10.287.600
Domain	PDZ	WHRN MAST1 SIPA1L2 TIAM2	3.76e-03	148	80	4	SM00228
Domain	CH	SPTBN2 PARVA IQGAP3	3.79e-03	73	80	3	PS50021
Domain	-	WHRN MAST1 SIPA1L2 TIAM2	3.94e-03	150	80	4	2.30.42.10
Domain	Tubulin_C	TUBA3D TUBA3E	3.96e-03	22	80	2	SM00865
Domain	Tubulin_C	TUBA3D TUBA3E	3.96e-03	22	80	2	PF03953
Domain	Tubulin/FtsZ_2-layer-sand-dom	TUBA3D TUBA3E	3.96e-03	22	80	2	IPR018316
Domain	-	TUBA3D TUBA3E	3.96e-03	22	80	2	3.40.50.1440
Domain	PDZ	WHRN MAST1 SIPA1L2 TIAM2	4.03e-03	151	80	4	PS50106
Domain	CH-domain	SPTBN2 PARVA IQGAP3	4.09e-03	75	80	3	IPR001715
Domain	PDZ	WHRN MAST1 SIPA1L2 TIAM2	4.13e-03	152	80	4	IPR001478
Domain	Tubulin_C	TUBA3D TUBA3E	4.32e-03	23	80	2	IPR023123
Domain	TUBULIN	TUBA3D TUBA3E	4.32e-03	23	80	2	PS00227
Domain	Tubulin	TUBA3D TUBA3E	4.32e-03	23	80	2	IPR000217
Domain	Tub_FtsZ_C	TUBA3D TUBA3E	4.32e-03	23	80	2	IPR008280
Domain	Tubulin	TUBA3D TUBA3E	4.32e-03	23	80	2	SM00864
Domain	Tubulin_CS	TUBA3D TUBA3E	4.32e-03	23	80	2	IPR017975
Domain	Tubulin_FtsZ_GTPase	TUBA3D TUBA3E	4.70e-03	24	80	2	IPR003008
Domain	Tubulin	TUBA3D TUBA3E	4.70e-03	24	80	2	PF00091
Domain	Spectrin_repeat	SPTBN2 PPL	6.82e-03	29	80	2	IPR002017
Domain	HMGI/Y_DNA-bd_CS	PRR12 PLEKHA4	7.77e-03	31	80	2	IPR000637
Domain	Spectrin/alpha-actinin	SPTBN2 PPL	8.27e-03	32	80	2	IPR018159
Domain	SPEC	SPTBN2 PPL	8.27e-03	32	80	2	SM00150
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	SPTBN2 ITPR1 ITPR2	7.77e-06	10	58	3	M47661
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_IQGAPS	TUBA3D TUBA3E TUBA3C IQGAP3	8.51e-06	32	58	4	M27491
Pathway	KEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C DNAH1	2.82e-05	43	58	4	M47669
Pathway	REACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS	TUBA3D TUBA3E GRIN3A TUBA3C	3.10e-05	44	58	4	M27934
Pathway	KEGG_GAP_JUNCTION	TUBA3D TUBA3E TUBA3C ITPR1 ITPR2	3.33e-05	90	58	5	M4013
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C DNAH1	3.39e-05	45	58	4	M47670
Pathway	REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION	B4GALT2 MOGS TUBA3D SEC24A SPTBN2 TUBA3E OS9 TUBA3C	3.44e-05	307	58	8	M894
Pathway	KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_ESPG_TO_MICROTUBULE_RHOA_SIGNALING_PATHWAY	TUBA3D TUBA3E TUBA3C	4.31e-05	17	58	3	M47768
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_DCTN1_TO_RETROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	5.16e-05	18	58	3	M47753
Pathway	KEGG_MEDICUS_ENV_FACTOR_IRON_TO_ANTEROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	6.11e-05	19	58	3	M47818
Pathway	KEGG_MEDICUS_ENV_FACTOR_ZN_TO_ANTEROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	6.11e-05	19	58	3	M47813
Pathway	REACTOME_INTRAFLAGELLAR_TRANSPORT	TNPO1 IFT140 TUBA3D TUBA3C	7.00e-05	54	58	4	M27482
Pathway	KEGG_MEDICUS_REFERENCE_KINETOCHORE_MICROTUBULE_ATTACHMENT	TUBA3D TUBA3E TUBA3C	7.17e-05	20	58	3	M47890
Pathway	KEGG_MEDICUS_REFERENCE_MICROTUBULE_DEPOLYMERIZATION_AT_THE_MINUS_ENDS	TUBA3D TUBA3E TUBA3C	7.17e-05	20	58	3	M47911
Pathway	REACTOME_TRANSPORT_OF_CONNEXONS_TO_THE_PLASMA_MEMBRANE	TUBA3D TUBA3E TUBA3C	8.34e-05	21	58	3	M27067
Pathway	KEGG_MEDICUS_REFERENCE_MICROTUBULE_RHOA_SIGNALING_PATHWAY	TUBA3D TUBA3E TUBA3C	8.34e-05	21	58	3	M47767
Pathway	KEGG_MEDICUS_REFERENCE_PROMOTION_OF_MICROTUBULE_GROWTH	TUBA3D TUBA3E TUBA3C	9.63e-05	22	58	3	M47903
Pathway	REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY	TUBA3D TUBA3E TUBA3C	1.10e-04	23	58	3	M19135
Pathway	KEGG_MEDICUS_REFERENCE_MICROTUBULE_DEPOLYMERIZATION	TUBA3D TUBA3E TUBA3C	1.10e-04	23	58	3	M47910
Pathway	KEGG_MEDICUS_REFERENCE_KINETOCHORE_FIBER_ORGANIZATION	TUBA3D TUBA3E TUBA3C	1.10e-04	23	58	3	M47900
Pathway	REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION	B4GALT2 TUBA3D SEC24A SPTBN2 TUBA3E TUBA3C	1.15e-04	187	58	6	M961
Pathway	KEGG_MEDICUS_REFERENCE_ANTEROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	1.26e-04	24	58	3	M47671
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_ANTEROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	1.26e-04	24	58	3	M47700
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SIFA_TO_MICROTUBULE_PLUS_END_DIRECTED_TRANSPORT	TUBA3D TUBA3E TUBA3C	1.43e-04	25	58	3	M47775
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_ANTEROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	1.43e-04	25	58	3	M47710
Pathway	REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC	TUBA3D TUBA3E TUBA3C	1.61e-04	26	58	3	M9648
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_ANTEROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	1.61e-04	26	58	3	M47672
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR1 ITPR2	1.65e-04	5	58	2	M49000
Pathway	REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION	TUBA3D SEC24A SPTBN2 TUBA3E TUBA3C	1.65e-04	126	58	5	M705
Pathway	REACTOME_CILIUM_ASSEMBLY	TNPO1 IFT140 AKAP9 TUBA3D TUBA3E TUBA3C	1.70e-04	201	58	6	M27472
Pathway	KEGG_MEDICUS_REFERENCE_MICROTUBULE_NUCLEATION	TUBA3D TUBA3E TUBA3C	2.01e-04	28	58	3	M47898
Pathway	REACTOME_ACTIVATION_OF_AMPK_DOWNSTREAM_OF_NMDARS	TUBA3D TUBA3E TUBA3C	2.24e-04	29	58	3	M27948
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	2.47e-04	6	58	2	M47960
Pathway	REACTOME_NUCLEAR_ENVELOPE_NE_REASSEMBLY	TNPO1 TUBA3D TUBA3E TUBA3C	2.65e-04	76	58	4	M27215
Pathway	REACTOME_SEALING_OF_THE_NUCLEAR_ENVELOPE_NE_BY_ESCRT_III	TUBA3D TUBA3E TUBA3C	3.01e-04	32	58	3	M29848
Pathway	REACTOME_COOPERATION_OF_PREFOLDIN_AND_TRIC_CCT_IN_ACTIN_AND_TUBULIN_FOLDING	TUBA3D TUBA3E TUBA3C	3.30e-04	33	58	3	M27297
Pathway	KEGG_MEDICUS_REFERENCE_BRANCHING_MICROTUBULE_NUCLEATION	TUBA3D TUBA3E TUBA3C	3.30e-04	33	58	3	M47901
Pathway	REACTOME_SIGNALING_BY_HEDGEHOG	IFT140 TUBA3D OS9 IHH TUBA3C	3.71e-04	150	58	5	M27440
Pathway	KEGG_MEDICUS_REFERENCE_ARL8_REGULATED_MICROTUBULE_PLUS_END_DIRECTED_TRANSPORT	TUBA3D TUBA3E TUBA3C	3.94e-04	35	58	3	M47774
Pathway	REACTOME_ER_TO_GOLGI_ANTEROGRADE_TRANSPORT	TUBA3D SEC24A SPTBN2 TUBA3E TUBA3C	4.45e-04	156	58	5	M27097
Pathway	REACTOME_GAP_JUNCTION_ASSEMBLY	TUBA3D TUBA3E TUBA3C	5.03e-04	38	58	3	M14981
Pathway	KEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	5.88e-04	9	58	2	M47852
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	TUBA3D TUBA3E GRIN3A TUBA3C	5.97e-04	94	58	4	M2843
Pathway	REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES	AKAP9 TUBA3D TUBA3E TUBA3C	6.22e-04	95	58	4	M6729
Pathway	KEGG_MEDICUS_REFERENCE_RAB7_REGULATED_MICROTUBULE_MINUS_END_DIRECTED_TRANSPORT	TUBA3D TUBA3E TUBA3C	7.26e-04	43	58	3	M47773
Pathway	REACTOME_AGGREPHAGY	TUBA3D TUBA3E TUBA3C	7.77e-04	44	58	3	M29830
Pathway	REACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT	TUBA3D SPTBN2 TUBA3E TUBA3C	8.12e-04	102	58	4	M27648
Pathway	REACTOME_CARBOXYTERMINAL_POST_TRANSLATIONAL_MODIFICATIONS_OF_TUBULIN	TUBA3D TUBA3E TUBA3C	8.85e-04	46	58	3	M27828
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	8.93e-04	11	58	2	M49033
Pathway	REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION	ITPR1 ITPR2	8.93e-04	11	58	2	M27466
Pathway	REACTOME_RECYCLING_PATHWAY_OF_L1	TUBA3D TUBA3E TUBA3C	1.06e-03	49	58	3	M891
Pathway	REACTOME_GAP_JUNCTION_TRAFFICKING_AND_REGULATION	TUBA3D TUBA3E TUBA3C	1.20e-03	51	58	3	M26972
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	1.26e-03	13	58	2	M47656
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.26e-03	13	58	2	M47696
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.26e-03	13	58	2	M47751
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2	1.26e-03	13	58	2	MM14553
Pathway	REACTOME_INTRAFLAGELLAR_TRANSPORT	TNPO1 IFT140 TUBA3D	1.27e-03	52	58	3	MM15211
Pathway	REACTOME_COPI_INDEPENDENT_GOLGI_TO_ER_RETROGRADE_TRAFFIC	TUBA3D TUBA3E TUBA3C	1.34e-03	53	58	3	M27651
Pathway	REACTOME_ORGANELLE_BIOGENESIS_AND_MAINTENANCE	TNPO1 IFT140 AKAP9 TUBA3D TUBA3E TUBA3C	1.34e-03	297	58	6	M27050
Pathway	WP_PATHOGENIC_ESCHERICHIA_COLI_INFECTION	TUBA3D TUBA3E TUBA3C	1.49e-03	55	58	3	M39613
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	TUBA3D TUBA3E GRIN3A TUBA3C CHRNA3	1.52e-03	205	58	5	M752
Pathway	REACTOME_L1CAM_INTERACTIONS	TUBA3D SPTBN2 TUBA3E TUBA3C	1.53e-03	121	58	4	M872
Pathway	KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION	TUBA3D TUBA3E TUBA3C	1.57e-03	56	58	3	M2333
Pathway	REACTOME_HSP90_CHAPERONE_CYCLE_FOR_STEROID_HORMONE_RECEPTORS_SHR_IN_THE_PRESENCE_OF_LIGAND	TUBA3D TUBA3E TUBA3C	1.65e-03	57	58	3	M27251
Pathway	KEGG_MEDICUS_REFERENCE_N_GLYCAN_BIOSYNTHESIS	B4GALT2 MOGS	1.92e-03	16	58	2	M47632
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2	1.92e-03	16	58	2	M26945
Pathway	REACTOME_KINESINS	TUBA3D TUBA3E TUBA3C	2.01e-03	61	58	3	M977
Pathway	REACTOME_SIGNALING_BY_HEDGEHOG	IFT140 TUBA3D OS9 IHH	2.41e-03	137	58	4	MM15182
Pathway	REACTOME_HCMV_EARLY_EVENTS	TUBA3D TUBA3E NUP214 TUBA3C	2.48e-03	138	58	4	M29805
Pathway	REACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS	MUC4 TAB3 ITPR1 ITPR2	2.61e-03	140	58	4	M27484
Pathway	REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION	ITPR1 ITPR2	2.72e-03	19	58	2	M27423
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	2.72e-03	19	58	2	M47760
Pathway	KEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	2.72e-03	19	58	2	M47733
Pathway	KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	3.01e-03	20	58	2	M47688
Pathway	WP_PARKINUBIQUITIN_PROTEASOMAL_SYSTEM_PATHWAY	TUBA3D TUBA3E TUBA3C	3.10e-03	71	58	3	M39690
Pathway	REACTOME_TRANSLOCATION_OF_SLC2A4_GLUT4_TO_THE_PLASMA_MEMBRANE	TUBA3D TUBA3E TUBA3C	3.22e-03	72	58	3	M26954
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	3.32e-03	21	58	2	M47689
Pathway	REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES	TUBA3D TUBA3E NUP214 TUBA3C	3.43e-03	151	58	4	M550
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	3.65e-03	22	58	2	M47690
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	3.65e-03	22	58	2	M47675
Pathway	REACTOME_PKR_MEDIATED_SIGNALING	TUBA3D TUBA3E TUBA3C	3.76e-03	76	58	3	M48037
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	SYNJ1 ITPR1 ITPR2	3.76e-03	76	58	3	M9052
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	3.98e-03	23	58	2	M47676
Pathway	REACTOME_INFECTIOUS_DISEASE	MOGS TUBA3D SEC24A ENTPD1 TUBA3E NUP214 RPL4 TUBA3C TAB3 ITPR1 ITPR2	4.12e-03	1081	58	11	M27548
Pathway	REACTOME_THE_ROLE_OF_GTSE1_IN_G2_M_PROGRESSION_AFTER_G2_CHECKPOINT	TUBA3D TUBA3E TUBA3C	4.19e-03	79	58	3	M27743
Pathway	WP_ALZHEIMERS_DISEASE	TUBA3D TUBA3E TUBA3C ITPR1 ITPR2	4.31e-03	261	58	5	M42565
Pathway	REACTOME_HCMV_INFECTION	TUBA3D TUBA3E NUP214 TUBA3C	4.40e-03	162	58	4	M29804
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	ITPR1 ITPR2	4.70e-03	25	58	2	MM14511
Pathway	REACTOME_MUSCLE_CONTRACTION	AKAP9 NEB ITPR1 ITPR2	4.70e-03	165	58	4	MM15026
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	TUBA3D TUBA3E GRIN3A TUBA3C CHRNA3	4.98e-03	270	58	5	M15514
Pathway	KEGG_GALACTOSE_METABOLISM	B4GALT2 HK3	5.07e-03	26	58	2	M4377
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR1 ITPR2	5.47e-03	27	58	2	MM15053
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	ITPR1 ITPR2	5.47e-03	27	58	2	M12123
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR1 ITPR2	5.87e-03	28	58	2	M924
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	TNPO1 C5orf34 UBE2O AKAP9 MOGS SPTBN2 KIAA1549 ROBO1 OS9 FNDC3A E2F6 CRYBG3 SIPA1L2 RPL4 ITPR1 ITPR2	4.71e-07	1487	84	16	33957083
Pubmed	Huwe1, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity.	TUBA3D TUBA3E TUBA3C	1.13e-06	9	84	3	21167302
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	UBE2O NKD2 SEC24A KIAA1549 CRYBG3 SIPA1L2 TAB3	3.60e-06	263	84	7	34702444
Pubmed	An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.	ITPR1 ITPR2	5.76e-06	2	84	2	18708078
Pubmed	Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.	ITPR1 ITPR2	5.76e-06	2	84	2	15201137
Pubmed	Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.	ITPR1 ITPR2	5.76e-06	2	84	2	23582047
Pubmed	Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.	ITPR1 ITPR2	5.76e-06	2	84	2	19120126
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	WHRN AKAP9 MAST1 GON4L NUP214 SIPA1L2 ARHGEF17 SON	6.59e-06	407	84	8	12693553
Pubmed	HIV-1 Tat protein enhances microtubule polymerization.	TUBA3D TUBA3E TUBA3C	1.28e-05	19	84	3	15691386
Pubmed	HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?	TUBA3D TUBA3E TUBA3C	1.28e-05	19	84	3	15698476
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR2	1.73e-05	3	84	2	10874040
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR2	1.73e-05	3	84	2	9808793
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR2	1.73e-05	3	84	2	20395455
Pubmed	De novo point mutations in patients diagnosed with ataxic cerebral palsy.	SPTBN2 ITPR1	1.73e-05	3	84	2	25981959
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR2	1.73e-05	3	84	2	17437169
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR2	1.73e-05	3	84	2	18194433
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR2	1.73e-05	3	84	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR2	1.73e-05	3	84	2	36350267
Pubmed	Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.	ITPR1 ITPR2	1.73e-05	3	84	2	32320395
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR2	1.73e-05	3	84	2	27777977
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR2	1.73e-05	3	84	2	11413485
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	1.73e-05	3	84	2	26009177
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR1 ITPR2	1.73e-05	3	84	2	17581770
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR1 ITPR2	1.73e-05	3	84	2	18241669
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR2	1.73e-05	3	84	2	1693919
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR1 ITPR2	1.73e-05	3	84	2	19068129
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR2	1.73e-05	3	84	2	23955339
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR2	1.73e-05	3	84	2	31979185
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR2	1.73e-05	3	84	2	24904548
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	1.73e-05	3	84	2	17327232
Pubmed	Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.	ITPR1 ITPR2	1.73e-05	3	84	2	23223241
Pubmed	Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity.	DISC1 ITPR1	1.73e-05	3	84	2	25821909
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR1 ITPR2	1.73e-05	3	84	2	16014380
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR1 ITPR2	1.73e-05	3	84	2	17890015
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR1 ITPR2	1.73e-05	3	84	2	23983250
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR2	1.73e-05	3	84	2	9858485
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR1 ITPR2	1.73e-05	3	84	2	20427533
Pubmed	Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity.	TUBA3D TUBA3E TUBA3C	2.02e-05	22	84	3	23826228
Pubmed	F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells.	TUBA3D TUBA3E TUBA3C	2.02e-05	22	84	3	28117675
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	EFCAB5 FAT2 GON4L NEB ARHGEF17 FER1L6	2.28e-05	234	84	6	36243803
Pubmed	A human MAP kinase interactome.	IFT140 SPTBN2 ROBO1 OS9 CHD8 NKTR NUP214 NEB	2.36e-05	486	84	8	20936779
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ARMT1 AKAP9 GON4L OS9 PUM3 NEB PHGDH SON	2.77e-05	497	84	8	23414517
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR1 ITPR2	3.45e-05	4	84	2	25215520
Pubmed	Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.	ITPR1 ITPR2	3.45e-05	4	84	2	21424589
Pubmed	Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease.	ENTPD1 IL9R	3.45e-05	4	84	2	25421756
Pubmed	Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.	ITPR1 ITPR2	3.45e-05	4	84	2	21818117
Pubmed	Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.	ITPR1 ITPR2	3.45e-05	4	84	2	28615414
Pubmed	Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.	ITPR1 ITPR2	3.45e-05	4	84	2	10828023
Pubmed	IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.	ITPR1 ITPR2	3.45e-05	4	84	2	28419336
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	ITPR1 ITPR2	3.45e-05	4	84	2	19120137
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	3.45e-05	4	84	2	11163362
Pubmed	IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.	ITPR1 ITPR2	3.45e-05	4	84	2	35494252
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	FAT2 AKAP9 HMCN1 NUP214 NEB	3.49e-05	152	84	5	34299191
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	IFT140 RELCH UBE2O UBXN7 KIAA1549 FNDC3A CHD8 TIAM2	4.30e-05	529	84	8	14621295
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ARMT1 RELCH AKAP9 SEC24A SPTBN2 KIAA1549 ROBO1 CRYBG3 TAB3 ITPR1 ITPR2	4.44e-05	1049	84	11	27880917
Pubmed	Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.	PCDH8 CHRNA3 ITPR1	5.26e-05	30	84	3	22837378
Pubmed	A role for E2F6 in the restriction of male-germ-cell-specific gene expression.	TUBA3D E2F6	5.74e-05	5	84	2	15936277
Pubmed	InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.	ITPR1 ITPR2	5.74e-05	5	84	2	21568942
Pubmed	BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.	ITPR1 ITPR2	5.74e-05	5	84	2	11782428
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PRR12 SYNJ1 CHD8 NUP214 DENND5A SIPA1L2 IQGAP3 TIAM2 WDR24 PPP1R16A ITPR2	7.07e-05	1105	84	11	35748872
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	ITPR1 ITPR2	8.59e-05	6	84	2	23463619
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	ITPR1 ITPR2	8.59e-05	6	84	2	21762810
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	ITPR1 ITPR2	8.59e-05	6	84	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	ITPR1 ITPR2	8.59e-05	6	84	2	25966694
Pubmed	Karyopherin beta2 mediates nuclear import of a mRNA binding protein.	TNPO1 NUP214	8.59e-05	6	84	2	9144189
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	ITPR1 ITPR2	8.59e-05	6	84	2	16844763
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	AKAP9 DCHS1 CHD8 NUP214	1.08e-04	101	84	4	26949739
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	TNPO1 MOGS DISC1 B3GALT6 NUP214 SIPA1L2 IQGAP3 SON	1.11e-04	606	84	8	36538041
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	FAT2 DCHS1	1.20e-04	7	84	2	16059920
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	ITPR1 ITPR2	1.20e-04	7	84	2	11860456
Pubmed	Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.	ITPR1 ITPR2	1.20e-04	7	84	2	22495310
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	PRR12 MOGS SEC24A PUM3 FNDC3A NUP214 PHGDH	1.22e-04	457	84	7	32344865
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	MOGS SEC24A OS9 FNDC3A MFSD10 ITPR1 ITPR2	1.42e-04	468	84	7	31056421
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	ARMT1 AKAP9 MOGS TUBA3D CHD8 RPL4 IQGAP3 PHGDH DNAH1	1.45e-04	807	84	9	30575818
Pubmed	Proteomic identification of brain proteins that interact with dynein light chain LC8.	MAST1 GRIN3A TUBA3C	1.46e-04	42	84	3	14760703
Pubmed	The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors.	AKAP9 DISC1	1.60e-04	8	84	2	22031837
Pubmed	Human transcription factor protein interaction networks.	PRR12 UBE2O HOXD11 SEC24A UBXN7 GON4L PUM3 CHD8 E2F6 ELK3 NUP214 TAB3	1.62e-04	1429	84	12	35140242
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PRR12 MOGS GON4L CHD8 DENND5A CRYBG3 IQGAP3 ITPR1	1.79e-04	650	84	8	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TNPO1 UBE2O SPTBN2 PUM3 CHD8 NUP214 RPL4 SON	1.84e-04	653	84	8	22586326
Pubmed	Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.	FAT2 SPTBN2 ITPR1	1.91e-04	46	84	3	34815492
Pubmed	Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod.	HOXD11 IHH	2.05e-04	9	84	2	14668414
Pubmed	Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.	ITPR1 ITPR2	2.05e-04	9	84	2	25737585
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	WHRN IFT140 SPTBN2 KIAA1549	2.85e-04	130	84	4	12421765
Pubmed	SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.	MOGS TUBA3D TUBA3E RPL4 TUBA3C	2.92e-04	239	84	5	23246001
Pubmed	Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis.	ITPR1 ITPR2	3.13e-04	11	84	2	20824138
Pubmed	Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.	ITPR1 ITPR2	3.13e-04	11	84	2	27514653
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	TNPO1 SEC24A ROBO1 FNDC3A NUP214 CRYBG3 RPL4 PHGDH	3.17e-04	708	84	8	39231216
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	AKAP9 FNDC3A WDR24 ITPR2	3.68e-04	139	84	4	25476789
Pubmed	Strain-specific modifier genes governing craniofacial phenotypes.	B3GALT6 PHGDH	3.75e-04	12	84	2	22371338
Pubmed	Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice.	HOXD11 IHH	3.75e-04	12	84	2	22916278
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	MOGS DISC1 SPTBN2 PKHD1 TIGD4 ZNF831 ARHGEF17 ITPR2	4.10e-04	736	84	8	29676528
Pubmed	The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.	KIAA1549 CFAP74 ITPR2	4.21e-04	60	84	3	21555518
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	UBE2O SEC24A KIAA1549 ROBO1 OS9 FNDC3A RPL4 MFSD10 ITPR2	4.88e-04	952	84	9	38569033
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	B3GALT6 PUM3 DHX33 RPL4 IQGAP3 PHGDH WDR24 SON	5.02e-04	759	84	8	35915203
Pubmed	Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.	ITPR1 ITPR2	5.15e-04	14	84	2	34630045
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	PRR12 SYNJ1 CHD8 E2F6 NUP214 CRYBG3	5.37e-04	418	84	6	34709266
Pubmed	Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.	NARF NUP214	5.93e-04	15	84	2	20970119
Pubmed	Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.	ITPR1 ITPR2	5.93e-04	15	84	2	28578927
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	TNPO1 PARVA CHD8 NUP214 IQGAP3	6.19e-04	282	84	5	23667531
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	HK3 PUM3 NKTR NUP214 ITPR2	6.50e-04	285	84	5	32838362
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR2	3.03e-05	3	58	2	297
GeneFamily	Tubulins	TUBA3D TUBA3E TUBA3C	7.73e-05	26	58	3	778
GeneFamily	Cadherin related	FAT2 DCHS1	1.33e-03	17	58	2	24
GeneFamily	PDZ domain containing	WHRN MAST1 SIPA1L2 TIAM2	1.43e-03	152	58	4	1220
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_3\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	GRHL1 FAT2 SPTBN2 MUC4 PPL FER1L6	1.04e-06	176	84	6	8d9d0fb46c418b2067be58aec822e8c2b1561461
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	C5orf34 PLEKHA4 OXCT2 C1R E2F6 PCDH8	2.18e-06	200	84	6	f7c3a8f5ac156c05ad7335d6d142c154c7d86449
Disease	microlissencephaly (implicated_via_orthology)	TUBA3D TUBA3E TUBA3C	1.06e-06	8	80	3	DOID:0112234 (implicated_via_orthology)
Disease	lissencephaly 3 (implicated_via_orthology)	TUBA3D TUBA3E TUBA3C	1.06e-06	8	80	3	DOID:0112232 (implicated_via_orthology)
Disease	polymicrogyria (implicated_via_orthology)	TUBA3D TUBA3E TUBA3C	1.06e-06	8	80	3	DOID:0080918 (implicated_via_orthology)
Disease	Anoxic Encephalopathy	ITPR1 ITPR2	7.26e-06	2	80	2	C0003132
Disease	Brain Hypoxia	ITPR1 ITPR2	7.26e-06	2	80	2	C1527348
Disease	Anoxia of brain	ITPR1 ITPR2	7.26e-06	2	80	2	C0995195
Disease	Hypoxic Brain Damage	ITPR1 ITPR2	7.26e-06	2	80	2	C1140716
Disease	lissencephaly (implicated_via_orthology)	TUBA3D TUBA3E TUBA3C	5.36e-05	27	80	3	DOID:0050453 (implicated_via_orthology)
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR2	4.71e-04	12	80	2	DOID:1441 (implicated_via_orthology)
Disease	Mental Retardation, Psychosocial	DISC1 ENTPD1 GON4L CHD8	5.65e-04	139	80	4	C0025363
Disease	Profound Mental Retardation	DISC1 ENTPD1 GON4L CHD8	5.65e-04	139	80	4	C0020796
Disease	Mental deficiency	DISC1 ENTPD1 GON4L CHD8	5.65e-04	139	80	4	C0917816
Disease	mean corpuscular hemoglobin concentration	TNPO1 IFT140 NKD2 TIGD4 MAST1 GON4L NEB PHGDH PPP1R16A ITPR2	7.96e-04	1105	80	10	EFO_0004528
Disease	congenital heart disease (implicated_via_orthology)	CHD8 SON ITPR1	8.84e-04	69	80	3	DOID:1682 (implicated_via_orthology)
Disease	sphingosine 1-phosphate measurement	UBE2O ITPR1	1.08e-03	18	80	2	EFO_0800185
Disease	pulmonary function measurement	PCDH8 CHRNA3 ITPR1	1.21e-03	77	80	3	EFO_0003892
Disease	Disproportionate short stature	IFT140 B3GALT6 IHH	1.21e-03	77	80	3	C0878659
Disease	urate measurement, bone density	ROBO1 DHX33 PPL TIAM2 ITPR1 DNAH1 ITPR2	1.46e-03	619	80	7	EFO_0003923, EFO_0004531
Disease	Malignant neoplasm of breast	C5orf34 HK3 AKAP9 HOXD11 ROBO1 ELK3 NUP214 PCDH8 PHGDH	2.48e-03	1074	80	9	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
YRRIHEAIIQSPPID	ARMT1	121	Q9H993
PVDVQREHDPRFDTE	B3GALT6	251	Q96L58
PAQTVAVIIPFRHRE	B4GALT2	141	O60909
VVPRFQPISEHQTRE	AKAP9	2096	Q99996
LEHEVVARSRPTPQD	CHD8	2026	Q9HCK8
PHDVVREFLVSEQPV	CRYBG3	1351	Q68DQ2
RPVANVSDPVIIHFE	CHRNA3	51	P32297
PIRRVSVHPDYRQDE	C1R	536	P00736
HAEPPETIRSLQERI	DISC1	536	Q9NRI5
PIREEPRVFLEHGEQ	IQCC	201	Q4KMZ1
LSPRDPAHTVREIIE	PUM3	446	Q15397
HVDRDPQESVVPVRY	ITPR2	786	Q14571
FEHVDRISRPPEASR	KIAA1549	1466	Q9HCM3
FEQLAEVDVTPPVHR	ARHGEF17	1891	Q96PE2
NAEPRFRDEFVIPHL	RELCH	1076	Q9P260
HQQPPERRVVTVVFL	MFSD10	16	Q14728
LYHVPRRSEEPRNDV	MUC4	5261	Q99102
PPRTSHFRLRVVVQD	DCHS1	976	Q96JQ0
RPAFEVPAIVVEDAR	GPR162	236	Q16538
VDVLHRPELLFPENT	ITPR1	1636	Q14643
FAPRPAQVIIHVRDV	FAT2	1851	Q9NYQ8
EPHSPFRVELQTRAD	PCDH8	176	O95206
PEVEVTHETLQRNRP	PPL	871	O60437
DEAVVQAPRHAPVVR	NUP214	1006	P35658
VFFPPRPERVEHNVE	PMS2P1	156	A4D2B8
VEIVDVNDHAPRFPR	PCDHGC4	121	Q9Y5F7
RAREVIPRSQHQETP	ENTPD1	111	P49961
PIRPDIVNFVHTNLR	RPL4	31	P36578
HRVEPRSQEFVIPQE	HK3	116	P52790
AQPATVEHEVVRDLP	NKD2	401	Q969F2
HRACQVPEPEERFAV	IQGAP3	1251	Q86VI3
TRDPFPDVVHLEEQD	MAST1	331	Q9Y2H9
TDRRRIDLQVHVPPS	HMCN1	3791	Q96RW7
ARVPPEFLVQRAVHA	MOGS	496	Q13724
ISIVRHEFPRESQNP	GRIN3A	221	Q8TCU5
EFRVIFDSLEPHREP	DNAH1	3596	Q9P2D7
VDTLRDPHEINIFLP	EFCAB5	1121	A4FU69
HPEPTERVVVFDRNL	GRHL1	176	Q9NZI5
DVPAPREDSITVHIR	E2F6	211	O75461
VRRVVVVPQAPEFHP	FNDC3A	91	Q9Y2H6
LAPHVQPVREVAFRD	HOXD11	51	P31277
PLRTLFHQPEEEIED	GON4L	211	Q3T8J9
VDSVLHNPPSRREEV	DHX33	531	Q9H6R0
DPREPQFHAFIITRE	DENND5A	111	Q6IQ26
EDSPPVEEVRTVIRF	ELK3	171	P41970
VRVAVTDVDEPPEFR	CDH22	381	Q9UJ99
PLEQPERIRQRTHFV	C5orf34	46	Q96MH7
ECVPDTHVERPFRVA	IFT140	51	Q96RY7
SDVRVRGPVPQHVVE	PRRT3	876	Q5FWE3
TAIPVFDPRHREEAE	CFAP74	1496	Q9C0B2
PHRLRAFQVIETQDP	IHH	251	Q14623
RFLVDEPQHTIPDVF	FER1L6	706	Q2WGJ9
QVLHDLRQRFPEIPE	TAB3	11	Q8N5C8
FIRPQHAPFIRDVAV	SYNJ1	641	O43426
RPQCHFDIEINREPV	NKTR	6	P30414
ARRQPDVEQRPVVGH	PLEKHA4	626	Q9H4M7
EPHRRPEVQNATIEF	SEC24A	476	O95486
EEDNPEVVRPHNGRV	PPP1R16A	401	Q96I34
SVLEVPRENQPIHRE	SIPA1L2	456	Q9P2F8
VHRPDSEPDVNEVRA	WHRN	726	Q9P202
SRHIVREEEAAVPAP	PKHD1	3956	P08F94
QVSLVDPEYLPRRHV	IL9R	131	Q01113
PPAERTEDEEFLIQH	PRR12	631	Q9ULL5
FRAPIRLPDHVSIQV	PARVA	201	Q9NVD7
QPTEEDPEHRVRVRV	OS9	531	Q13438
PEDIHVPNIYVDRVI	OXCT2	256	Q9BYC2
HVPRAVFVDLEPTVV	TUBA3D	61	P0DPH8
QFQRLRISEDPDVHP	TIAM2	1591	Q8IVF5
VAEARRPAPFEVVFV	NXNL2	56	Q5VZ03
PEVQSRVPTLERHYE	SPTBN2	821	O15020
HVPRAVFVDLEPTVV	TUBA3C	61	P0DPH7
VRRPPEVFEQEIRQH	UBE2O	1116	Q9C0C9
RRVVIFVESFPAHPE	TIGD4	281	Q8IY51
LRQEDFPPRIVEHPS	ROBO1	61	Q9Y6N7
IPDSEQDIRPRFHRS	TNPO1	336	Q92973
VSTVRPHTEEEVRAP	UBXN7	66	O94888
VFTEEPPRDRALVDH	PHGDH	261	O43175
HVPRAVFVDLEPTVV	TUBA3E	61	Q6PEY2
VLPQEAFPLRHEIVD	WDR24	566	Q96S15
VPTQDRRTPVHEDIS	ZNF831	671	Q5JPB2
SAVVAEEHEVVPERP	SON	1266	P18583
PISRHAVRVAERNFP	GARIN5B	191	Q8N5Q1
DIPVRRPESSAHVQE	NARF	406	Q9UHQ1
PKDVPFVHVRRVNNV	NEB	5001	P20929