Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	C_TYPE_LECTIN_1	CD93 ATRN FCER2 SFTPD COLEC10	4.47e-06	80	57	5	PS00615
Domain	Lectin_C	CD93 ATRN FCER2 SFTPD COLEC10	5.68e-06	84	57	5	PF00059
Domain	CLECT	CD93 ATRN FCER2 SFTPD COLEC10	5.68e-06	84	57	5	SM00034
Domain	C_TYPE_LECTIN_2	CD93 ATRN FCER2 SFTPD COLEC10	6.03e-06	85	57	5	PS50041
Domain	C-type_lectin-like	CD93 ATRN FCER2 SFTPD COLEC10	6.38e-06	86	57	5	IPR001304
Domain	-	CD93 ATRN FCER2 SFTPD COLEC10	1.15e-05	97	57	5	3.10.100.10
Domain	C-type_lectin-like/link	CD93 ATRN FCER2 SFTPD COLEC10	1.27e-05	99	57	5	IPR016186
Domain	CTDL_fold	CD93 ATRN FCER2 SFTPD COLEC10	1.86e-05	107	57	5	IPR016187
Domain	EGF_LAM_2	ATRN LAMC2 USH2A	1.03e-04	30	57	3	PS50027
Domain	EGF_LAM_1	ATRN LAMC2 USH2A	1.03e-04	30	57	3	PS01248
Domain	Laminin_EGF	ATRN LAMC2 USH2A	1.65e-04	35	57	3	PF00053
Domain	EGF_Lam	ATRN LAMC2 USH2A	1.65e-04	35	57	3	SM00180
Domain	Laminin_EGF	ATRN LAMC2 USH2A	2.11e-04	38	57	3	IPR002049
Domain	C-type_lectin_CS	FCER2 SFTPD COLEC10	3.05e-04	43	57	3	IPR018378
Domain	CTLH_C	RANBP9 MKLN1	4.05e-04	10	57	2	IPR006595
Domain	CTLH	RANBP9 MKLN1	4.05e-04	10	57	2	PS50897
Domain	Gal_Oxase/kelch_b-propeller	ATRN MKLN1 KLHL31	7.76e-04	59	57	3	IPR011043
Domain	Kelch_1	ATRN MKLN1 KLHL31	1.28e-03	70	57	3	PF01344
Domain	Kelch_1	ATRN MKLN1 KLHL31	1.28e-03	70	57	3	IPR006652
Domain	LisH	RANBP9 MKLN1	3.29e-03	28	57	2	SM00667
Domain	LisH	RANBP9 MKLN1	3.29e-03	28	57	2	IPR006594
Domain	LISH	RANBP9 MKLN1	3.29e-03	28	57	2	PS50896
Pubmed	Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation.	RANBP9 MKLN1	2.83e-06	2	59	2	18710924
Pubmed	Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex.	RANBP9 MKLN1	8.48e-06	3	59	2	28668087
Pubmed	Identifying E3 Ligase Substrates With Quantitative Degradation Proteomics.	RANBP9 MKLN1	8.48e-06	3	59	2	37166757
Pubmed	Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking.	TMEM131 TRAPPC8	8.48e-06	3	59	2	32095531
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	CD93 PPARGC1B IL17A FCER2 SFTPD CD226 USP35 COLEC10 TNKS2	9.80e-06	824	59	9	20237496
Pubmed	A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM.	RANBP9 MKLN1	1.69e-05	4	59	2	12559565
Pubmed	Identification of CD112R as a novel checkpoint for human T cells.	CD226 INPP5D	4.23e-05	6	59	2	26755705
Pubmed	RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex.	RANBP9 MKLN1	4.23e-05	6	59	2	17467196
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ATRN FEZ1 ERC1 SCG3 RANBP9 MKLN1 TMEM131 TNKS2 REPS2 RPH3A	5.53e-05	1285	59	10	35914814
Pubmed	The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation.	RANBP9 MKLN1	5.91e-05	7	59	2	31285494
Pubmed	The human GID complex engages two independent modules for substrate recruitment.	RANBP9 HBP1	1.01e-04	9	59	2	34647674
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA7 PCDHA5	1.54e-04	11	59	2	9655502
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA7 PCDHA5	1.85e-04	12	59	2	10612399
Pubmed	Positional cloning of the murine flavivirus resistance gene.	PLBD2 RPH3A	2.54e-04	14	59	2	12080145
Pubmed	Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness.	CPXM2 REPS2	2.93e-04	15	59	2	22383091
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA7 PCDHA5	2.93e-04	15	59	2	15640798
Pubmed	Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing.	ATRN ZHX2	2.93e-04	15	59	2	19436707
Pubmed	Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification.	SCG3 CHEK1 RPH3A	3.10e-04	77	59	3	29445148
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA7 PCDHA5	3.79e-04	17	59	2	29911975
Pubmed	Transcript profiling during preimplantation mouse development.	PSG1 CHEK1	4.25e-04	18	59	2	15282163
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA7 PCDHA5	4.25e-04	18	59	2	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA7 PCDHA5	4.25e-04	18	59	2	10662547
Pubmed	The Exonuclease Trex2 Shapes Psoriatic Phenotype.	IL17A ERCC6	5.82e-04	21	59	2	27365293
Pubmed	KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.	ING3 SUV39H1	5.82e-04	21	59	2	27270040
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	TBATA CPXM2 SFTPD TNKS2 IFIT2	6.96e-04	415	59	5	16385451
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA7 PCDHA5	7.62e-04	24	59	2	24698270
Pubmed	Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells.	SCG3 INPP5D	8.28e-04	25	59	2	9560157
Pubmed	Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.	ERC1 RPH3A	8.96e-04	26	59	2	17124501
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA7 PCDHA5	1.04e-03	28	59	2	15347688
Pubmed	Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.	CD226 ZHX2	1.19e-03	30	59	2	20080650
Pubmed	Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.	ING3 RANBP9 REPS2	1.52e-03	133	59	3	15604093
Pubmed	Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation.	GTPBP1 MORC2 DDX55	1.55e-03	134	59	3	28695742
Cytoband	12q24.13	PLBD2 RPH3A	4.78e-04	25	59	2	12q24.13
Cytoband	5q32	PPARGC1B GLRA1	2.23e-03	54	59	2	5q32
Cytoband	11q24.2	FEZ1 CHEK1	3.02e-03	63	59	2	11q24.2
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CD93 ATRN FCER2 SFTPD COLEC10	3.73e-08	41	42	5	1298
GeneFamily	Collectins	SFTPD COLEC10	2.34e-04	10	42	2	491
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	CD93 FCER2 PSG1 CD226 KIR2DS4	2.10e-03	394	42	5	471
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED	CES5A SCG3 GLRA1 PCDHA7 PCDHA5 RPH3A	1.59e-05	238	59	6	M2020
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED	CES5A SCG3 GLRA1 PCDHA7 PCDHA5 RPH3A	2.67e-05	261	59	6	MM1277
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(MGE-derived_cortical_interneurons)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FCER2 CD226 TEX26 COLEC10	3.02e-06	75	59	4	6339b514a98511e409d86d4b9d460afe192557c0
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(MGE-derived_cortical_interneurons)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FCER2 CD226 TEX26 COLEC10	3.02e-06	75	59	4	a5bef117c483ce5afc38d96709370e8e53f4f2a9
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(MGE-derived_cortical_interneurons)--\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FCER2 CD226 TEX26 COLEC10	3.02e-06	75	59	4	75181a17aca2482f18f23beb31983d01043e02cb
Disease	severe acute respiratory syndrome, COVID-19	ATP8B3 DLGAP2 SFTPD INPP5D MKLN1 WDR41 KIR2DS4	3.02e-05	447	59	7	EFO_0000694, MONDO_0100096
Disease	respiratory syncytial virus infectious disease (is_marker_for)	IL17A SFTPD	5.89e-04	18	59	2	DOID:1273 (is_marker_for)
Disease	pulmonary surfactant-associated protein d measurement	PSG1 SFTPD	5.89e-04	18	59	2	EFO_0020693
Disease	unipolar depression, memory performance, cognitive function measurement	TEX26 TRAPPC8	7.30e-04	20	59	2	EFO_0003761, EFO_0004874, EFO_0008354
Disease	Acute Lung Injury	IL17A SFTPD	8.85e-04	22	59	2	C0242488
Disease	eye colour measurement	CD93 CES5A USH2A PLBD2	9.60e-04	218	59	4	EFO_0009764
Disease	cardiac troponin T measurement	DLGAP2 ING3 INPP5D TMEM131	9.76e-04	219	59	4	EFO_0005043
Disease	reticulocyte count	ATRN PSG1 CD226 INPP5D TMEM131 ZHX2 RPH3A TRIM10	1.08e-03	1045	59	8	EFO_0007986
Disease	macular degeneration (is_marker_for)	IL17A ERCC6	1.24e-03	26	59	2	DOID:4448 (is_marker_for)
Disease	1,5 anhydroglucitol measurement	PCDHA7 PCDHA5	1.54e-03	29	59	2	EFO_0008009
Disease	rhinitis (is_implicated_in)	IL17A SFTPD	1.65e-03	30	59	2	DOID:4483 (is_implicated_in)
Disease	lung squamous cell carcinoma (is_marker_for)	ERCC6 LAMC2	2.37e-03	36	59	2	DOID:3907 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HPYDGNSSDPENWDR	BTBD10	6	Q9BSF8
YWAQPQDALSQEVSP	AGK	286	Q53H12
LPWDQPSDSCQEYSD	CHEK1	206	O14757
SPRLNPQASWEFEAE	GTPBP1	481	O00178
PQNAADSYSWVPERA	CD93	621	Q9NPY3
TPLQNYSNWNEGEPS	COLEC10	226	Q9Y6Z7
LDPQYSWSPTQHFNE	DLGAP2	56	Q9P1A6
YQDSRAQRMSPWPQD	DLGAP2	641	Q9P1A6
PWPQDSRGLYNSTDS	DLGAP2	651	Q9P1A6
SEATTRPKENPYLWN	ATP8B3	521	O60423
IYDPDWNPSTDTQAR	ERCC6	931	Q03468
YPHESQLPEEWENNR	CPXM2	616	Q8N436
AYSDPWNSPVGNQLD	RANBP9	656	Q96S59
TPPASYNLDDDQAAW	ERC1	1046	Q8IUD2
SSTDNPRQPNPDWRY	PCDHA7	781	Q9UN72
SFRDAPYEWSNSSDP	KIR2DS4	201	P43632
YDPASDSWQELPNLS	KLHL31	486	Q9H511
PVPANQSFWTREEYS	ATRN	321	O75882
EVNWVLQYDPPSNAS	DDX55	336	Q8NHQ9
DSNSQVDWTYDPNEP	ING3	346	Q9NXR8
TIIQDWQPYRPSESN	NAT16	241	Q8N8M0
QPASPWDNLREATSY	CES5A	76	Q6NT32
DYSNWAPGEPTSRSQ	FCER2	241	P06734
DNYIPSLSEDWRDPN	FEZ1	111	Q99689
STDNPRQPNPDWRYS	PCDHA5	781	Q9Y5H7
TSPWNLHRNEDPERY	IL17A	71	Q16552
LSANWNQPPSSELRY	MORC2	471	Q9Y6X9
EHSLPPYQEDTDQWN	BCLAF3	241	A2AJT9
NYSSQPLDESWPRQQ	CRTC3	126	Q6UUV7
ASYRLDNWPPSQNAI	IFIT2	181	P09913
YPRSSWNQNTSDIPE	HBP1	86	O60381
EHPSNNWSPQLSYFE	LAMC2	321	Q13753
WDTQKAPNNYRSPIS	CD226	291	Q15762
ADSNPPAQYSWTINE	PSG1	356	P11464
AQAPPTFRAQDYTWE	SESN2	331	P58004
ASNPPEDLNRWHNIY	USH2A	2866	O75445
NRWMYPSDRPLQSND	RPH3A	11	Q9Y2J0
NDQSSRWSSESNYPP	MKLN1	41	Q9UL63
NPENTGPTLEWDNYD	RGPD2	1231	P0DJD1
WNDPRLAYNEYPDDS	GLRA1	96	P23415
LQWCPENSETEPNQY	PPARGC1B	61	Q86YN6
QTLSPDQQPTAWSYD	INPP5D	931	Q92835
DPQSNRNPQLSSEAW	TBATA	131	Q96M53
INFDNDSSIWNYPPN	NPAS3	656	Q8IXF0
DSSIWNYPPNREISR	NPAS3	661	Q8IXF0
ENEDRQTAWFPAPYL	NOXO1	206	Q8NFA2
GYPDSESTWEPRQNL	SUV39H1	66	O43463
QDNSSYPDEPWRITE	REPS2	266	Q8NFH8
SLVYSNWAPGEPNDD	SFTPD	331	P35247
ADRPEPENQWYLFND	USP35	881	Q9P2H5
SSPADDLGQTYNPWR	TMEM131	1846	Q92545
DPNARDNWNYTPLHE	TNKS2	116	Q9H2K2
RIDSSNFNPLPYWNA	PLCH1	661	Q4KWH8
RTENNDADYPWPRQC	UPK1B	176	O75841
TFARTQWPTPQEYDQ	ZHX2	646	Q9Y6X8
RAQFSYKWQNSPDNP	TRIM10	331	Q9UDY6
ASDEQIPDPWSQYLQ	TRAPPC8	236	Q9Y2L5
RNNWSEEDPDYPDYS	TMC5	6	Q6UXY8
PSAEDNQNLPSTWRE	TMC5	226	Q6UXY8
NQNLPSTWREPDYSD	TMC5	231	Q6UXY8
ESNPDSPYWHQVRLT	PLBD2	171	Q8NHP8
HNLQPTDDPNWDSYA	TEX26	16	Q8N6G2
AQTTNPYWADTNTRP	nan	81	Q6ZTI0
NNYEEDPNKPTSWTE	SCG3	206	Q8WXD2
QAYERNFWDPSPQLD	WDR41	256	Q9HAD4