Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaxon guidance receptor activity

EPHB2 EPHB3 HMCN2

6.24e-05131233GO:0008046
GeneOntologyMolecularFunctionintegrin binding

SELP ITGA2 ITGA2B JAM2 TLN1 TLN2 GPNMB

1.07e-041751237GO:0005178
GeneOntologyMolecularFunctionstructural constituent of skin epidermis

KRT81 KRT83 KRT85 KRT86

1.40e-04431234GO:0030280
GeneOntologyMolecularFunctionephrin receptor activity

EPHB2 EPHB3 EPHB4

2.06e-04191233GO:0005003
GeneOntologyBiologicalProcesscell-cell adhesion

EPHB3 EPHB4 SELP NPHS1 DCHS2 RAP1GAP PCDHGB2 CDHR2 PDPK1 HLA-DRB1 HLA-DRB5 ITGA2 ITGA2B PDLIM5 JAM2 RHOH FAT1 HMCN2 TLN1 TLN2 GPNMB PCDHGC3

3.69e-07107712322GO:0098609
GeneOntologyCellularComponentanchoring junction

NPHS1 DCHS2 CDHR2 PDPK1 PPP1R12A NCSTN ITGA2 ITGA2B PDLIM5 JAM2 FAT1 LLGL2 LLGL1 TLN1 ARMC5 TLN2 PCDHGC3

5.24e-0597612217GO:0070161
GeneOntologyCellularComponentfocal adhesion

NPHS1 PDPK1 PPP1R12A NCSTN ITGA2 ITGA2B FAT1 TLN1 ARMC5 TLN2

2.21e-0443112210GO:0005925
GeneOntologyCellularComponentcell-substrate junction

NPHS1 PDPK1 PPP1R12A NCSTN ITGA2 ITGA2B FAT1 TLN1 ARMC5 TLN2

2.75e-0444312210GO:0030055
HumanPhenoPerifollicular hyperkeratosis

KRT81 KRT83 KRT86

3.76e-064513HP:0007468
HumanPhenoAbnormal perifollicular morphology

KRT81 KRT83 KRT86

1.85e-056513HP:0031285
DomainKeratin_2_head

KRT81 KRT83 KRT85 KRT86

1.66e-05241224IPR032444
DomainKeratin_2_head

KRT81 KRT83 KRT85 KRT86

1.66e-05241224PF16208
DomainKeratin_II

KRT81 KRT83 KRT85 KRT86

2.32e-05261224IPR003054
Domain-

TLN1 TLN2

4.23e-05212221.20.1420.10
DomainVBS

TLN1 TLN2

4.23e-0521222PF08913
DomainVinculin-bd_dom

TLN1 TLN2

4.23e-0521222IPR015009
DomainTalin_cent

TLN1 TLN2

4.23e-0521222IPR015224
DomainTalin_middle

TLN1 TLN2

4.23e-0521222PF09141
DomainEphrin_rec_like

EPHB2 EPHB3 EPHB4

4.32e-05111223PF07699
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

5.73e-05121223PF15371
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

5.73e-05121223IPR027970
DomainRECEPTOR_TYR_KIN_V_2

EPHB2 EPHB3 EPHB4

9.39e-05141223PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHB2 EPHB3 EPHB4

9.39e-05141223PS00790
DomainTyr_kinase_rcpt_V_CS

EPHB2 EPHB3 EPHB4

9.39e-05141223IPR001426
DomainEphA2_TM

EPHB2 EPHB3 EPHB4

9.39e-05141223PF14575
DomainEphrin_rcpt_lig-bd_dom

EPHB2 EPHB3 EPHB4

9.39e-05141223IPR001090
DomainEph_TM

EPHB2 EPHB3 EPHB4

9.39e-05141223IPR027936
DomainEPH_lbd

EPHB2 EPHB3 EPHB4

9.39e-05141223SM00615
DomainEphrin_lbd

EPHB2 EPHB3 EPHB4

9.39e-05141223PF01404
DomainTyr_kinase_ephrin_rcpt

EPHB2 EPHB3 EPHB4

9.39e-05141223IPR016257
DomainEPH_LBD

EPHB2 EPHB3 EPHB4

9.39e-05141223PS51550
DomainTalin-1

TLN1 TLN2

1.26e-0431222IPR015710
DomainLLGL

LLGL2 LLGL1

2.52e-0441222PF08366
DomainILWEQ_dom

TLN1 TLN2

2.52e-0441222IPR002558
DomainILWEQ

TLN1 TLN2

2.52e-0441222SM00307
DomainFERM_f0

TLN1 TLN2

2.52e-0441222PF16511
DomainILWEQ

TLN1 TLN2

2.52e-0441222PD011820
Domain-

TLN1 TLN2

2.52e-04412221.20.1410.10
DomainI_LWEQ

TLN1 TLN2

2.52e-0441222PF01608
DomainI_LWEQ

TLN1 TLN2

2.52e-0441222PS50945
DomainLethal2_giant

LLGL2 LLGL1

2.52e-0441222IPR000664
DomainFERM_f0

TLN1 TLN2

2.52e-0441222IPR032425
DomainLLGL2

LLGL2 LLGL1

2.52e-0441222IPR013577
DomainGrowth_fac_rcpt_

EPHB2 EPHB3 EPHB4 KRT83 FAT1 HMCN2

5.62e-041561226IPR009030
DomainEphrin_rec_like

EPHB2 EPHB3 EPHB4

5.63e-04251223SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

EPHB2 EPHB3 EPHB4

5.63e-04251223IPR011641
DomainCadherin_CS

DCHS2 PCDHGB2 CDHR2 FAT1 PCDHGC3

7.45e-041091225IPR020894
DomainIntermediate_filament_CS

KRT81 KRT83 KRT85 KRT86

7.67e-04631224IPR018039
DomainVinculin/catenin

TLN1 TLN2

8.70e-0471222IPR006077
DomainCADHERIN_1

DCHS2 PCDHGB2 CDHR2 FAT1 PCDHGC3

8.76e-041131225PS00232
DomainCadherin

DCHS2 PCDHGB2 CDHR2 FAT1 PCDHGC3

8.76e-041131225PF00028
DomainCADHERIN_2

DCHS2 PCDHGB2 CDHR2 FAT1 PCDHGC3

9.12e-041141225PS50268
Domain-

DCHS2 PCDHGB2 CDHR2 FAT1 PCDHGC3

9.12e-0411412252.60.40.60
DomainCA

DCHS2 PCDHGB2 CDHR2 FAT1 PCDHGC3

9.48e-041151225SM00112
DomainCadherin-like

DCHS2 PCDHGB2 CDHR2 FAT1 PCDHGC3

9.86e-041161225IPR015919
DomainCadherin

DCHS2 PCDHGB2 CDHR2 FAT1 PCDHGC3

1.06e-031181225IPR002126
DomainMHC_II_b_N

HLA-DRB1 HLA-DRB5

1.15e-0381222PD000328
DomainFilament

KRT81 KRT83 KRT85 KRT86

1.20e-03711224SM01391
DomainIF

KRT81 KRT83 KRT85 KRT86

1.27e-03721224PS00226
DomainFilament

KRT81 KRT83 KRT85 KRT86

1.33e-03731224PF00038
DomainMHC_II_b_N

HLA-DRB1 HLA-DRB5

1.48e-0391222IPR000353
DomainMHC_II_beta

HLA-DRB1 HLA-DRB5

1.48e-0391222SM00921
DomainMHC_II_beta

HLA-DRB1 HLA-DRB5

1.48e-0391222PF00969
DomainIF

KRT81 KRT83 KRT85 KRT86

1.55e-03761224IPR001664
DomainSAM

EPHB2 EPHB3 EPHB4 TNKS

2.65e-03881224SM00454
DomainSAM_DOMAIN

EPHB2 EPHB3 EPHB4 TNKS

3.49e-03951224PS50105
DomainMHC_II_a/b_N

HLA-DRB1 HLA-DRB5

3.66e-03141222IPR014745
DomainIRS

TLN1 TLN2

3.66e-03141222PF02174
DomainIRS_PTB

TLN1 TLN2

3.66e-03141222IPR002404
Domain-

HLA-DRB1 HLA-DRB5

3.66e-031412223.10.320.10
DomainSAM

EPHB2 EPHB3 EPHB4 TNKS

3.76e-03971224IPR001660
DomainAnk

TRPV1 CTTNBP2 PPP1R12A RIPK4 LRRK1 TNKS

3.87e-032281226PF00023
Domainfn3

EPHB2 EPHB3 EPHB4 NPHS1 FNDC7

4.24e-031621225PF00041
DomainIntegrin_alpha_C_CS

ITGA2 ITGA2B

4.78e-03161222IPR018184
Domain-

EPHB2 EPHB3 EPHB4 TNKS

5.16e-0310612241.10.150.50
DomainIntegrin_alpha-2

ITGA2 ITGA2B

6.05e-03181222IPR013649
DomainINTEGRIN_ALPHA

ITGA2 ITGA2B

6.05e-03181222PS00242
DomainIntegrin_alpha2

ITGA2 ITGA2B

6.05e-03181222PF08441
DomainIntegrin_alpha

ITGA2 ITGA2B

6.05e-03181222IPR000413
DomainANK

TRPV1 CTTNBP2 PPP1R12A RIPK4 LRRK1 TNKS

6.14e-032511226SM00248
DomainANK_REPEAT

TRPV1 CTTNBP2 PPP1R12A RIPK4 LRRK1 TNKS

6.38e-032531226PS50088
DomainANK_REP_REGION

TRPV1 CTTNBP2 PPP1R12A RIPK4 LRRK1 TNKS

6.50e-032541226PS50297
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY

ITGA2 ITGA2B TLN1 TLN2

3.13e-0530864M47724
PathwayREACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS

EPHB2 EPHB3 EPHB4 NCSTN

5.21e-0534864MM15025
PathwayWP_NEURAL_CREST_CELL_MIGRATION_DURING_DEVELOPMENT

EPHB2 EPHB3 EPHB4 STAT3

9.98e-0540864M39798
PathwayWP_NEURAL_CREST_CELL_MIGRATION_IN_CANCER

EPHB2 EPHB3 EPHB4 STAT3

1.33e-0443864M39788
PathwayREACTOME_EPHRIN_SIGNALING

EPHB2 EPHB3 EPHB4

1.67e-0418863MM15024
PathwayREACTOME_EPHRIN_SIGNALING

EPHB2 EPHB3 EPHB4

1.98e-0419863M27310
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

EPHB2 EPHB3 EPHB4 RAP1GAP KRT81 KRT83 KRT85 KRT86 NCSTN ITGA2B TLN1

2.29e-045028611MM14537
PathwayREACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS

EPHB2 EPHB3 EPHB4 NCSTN

2.59e-0451864M27311
Pubmed

The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.

SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1

2.37e-096125420850414
Pubmed

Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.

SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1

2.37e-096125425930072
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

PPP1R12A SH3BP2 MAZ KAT6A LPCAT4 KIAA1549 SKI PASK TBC1D10B FAT1 RESF1 HMCN2 CHD5 NUP188 TAF4B ADGRL2 VPS51 MGA ALG13

1.95e-0811161251931753913
Pubmed

Novel KRT83 and KRT86 mutations associated with monilethrix.

KRT81 KRT83 KRT86

4.53e-083125325557232
Pubmed

Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel Potential Indicators of Muscular Invasion.

EPHB2 EPHB3 EPHB4

4.53e-083125334296545
Pubmed

Structure and site of expression of a murine type II hair keratin.

KRT81 KRT83 KRT86

4.53e-08312531372089
Pubmed

Transient expression of mouse hair keratins in transfected HeLa cells: interactions between "hard" and "soft" keratins.

KRT81 KRT83 KRT86

4.53e-08312531712823
Pubmed

Sequences and differential expression of three novel human type-II hair keratins.

KRT83 KRT85 KRT86

4.53e-08312539084137
Pubmed

Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain.

KRT81 KRT83 KRT85 KRT86

7.70e-0812125410692104
Pubmed

Keratins of the human hair follicle.

KRT81 KRT83 KRT86

1.81e-074125315797458
Pubmed

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

ITGA2 ITGA2B TLN1

4.51e-075125318086863
Pubmed

Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting.

EPHB2 EPHB3 EPHB4 MUC5B

5.91e-0719125435294885
Pubmed

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.

EPHB2 EPHB3 EPHB4

1.57e-06712539990854
Pubmed

Similarities and Differences in the Way Transmembrane-Type Ligands Interact with the Elk Subclass of Eph Receptors.

EPHB2 EPHB3 EPHB4

1.57e-06712538954633
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1

1.60e-0624125432212159
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

PLEKHG4 PPP1R12A MTMR1 SKI STAT3 SF3B1 AP5Z1 TMF1 ZFR ADGRL2 CABIN1 MGA HSD17B8 TP53BP1

2.68e-068571251425609649
Pubmed

Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature.

EPHB2 EPHB3 EPHB4

3.75e-069125311403717
Pubmed

EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis.

EPHB2 EPHB3 EPHB4

3.75e-069125333253166
Pubmed

EphB/syndecan-2 signaling in dendritic spine morphogenesis.

EPHB2 EPHB3 EPHB4

3.75e-069125311580899
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

RAP1GAP CTTNBP2 PPP1R12A KIAA1549 MTMR1 ITGA2 PFKM PDLIM5 NWD2 SF3B1 WASHC5 MTERF2 TLN1 KNDC1 TLN2 VPS51 PPP6R2 KNG1

3.78e-0614311251837142655
Pubmed

EphB signaling regulates target innervation in the developing and deafferented auditory brainstem.

EPHB2 EPHB3 EPHB4

5.34e-0610125322021100
Pubmed

EphB2 guides axons at the midline and is necessary for normal vestibular function.

EPHB2 EPHB3 EPHB4

5.34e-0610125310839360
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

HEXA EPHB4 RAP1GAP ZEB1 FYTTD1 PLEKHG4 PPP1R12A SH3BP2 IQCN TBC1D10B TLN1 ARMC5 ALG13 S100PBP

6.41e-069251251428986522
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

ZHX3 KRT83 KRT85 PPP1R12A NACA PFKM FBXO30 LLGL1 TLN2 TP53BP1

8.51e-064721251038943005
Pubmed

Interaction of H-2Eb with an IAP retrotransposon in the A20/2J B cell lymphoma.

HLA-DRB1 HLA-DRB5

1.28e-05212521353478
Pubmed

Complete cDNA sequences of the HLA-DRB1*14011, *1402, *1403 and *1404 alleles.

HLA-DRB1 HLA-DRB5

1.28e-052125211972886
Pubmed

Novel HLA-DRB1 alleles discovered during routine sequencing based typing, DRB1*03052, DRB1*04032, DRB1*1139 and DRB1*1346.

HLA-DRB1 HLA-DRB5

1.28e-052125212028548
Pubmed

ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM.

ZEB1 PFKM

1.28e-052125233897890
Pubmed

Complete coding region sequence of E beta k cDNA clones: lack of polymorphism in the NH2-terminus between E beta k and E beta b molecules.

HLA-DRB1 HLA-DRB5

1.28e-05212523150763
Pubmed

Complete cDNA sequence of the HLA-DRB1*09012 allele.

HLA-DRB1 HLA-DRB5

1.28e-05212529777332
Pubmed

Isolation and characterization of a cDNA clone for the murine I-E beta polypeptide chain.

HLA-DRB1 HLA-DRB5

1.28e-05212526324181
Pubmed

The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration.

LLGL2 LLGL1

1.28e-052125222219375
Pubmed

Mouse MHC class II gene E beta 2 is closely related to E beta and to HLA-DR beta.

HLA-DRB1 HLA-DRB5

1.28e-05212522989167
Pubmed

Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation.

LLGL2 LLGL1

1.28e-052125223110097
Pubmed

The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer.

ZEB1 LLGL2

1.28e-052125218199550
Pubmed

RIP4 upregulates CCL20 expression through STAT3 signalling in cultured keratinocytes.

RIPK4 STAT3

1.28e-052125230044012
Pubmed

A missense mutation in the type II hair keratin hHb3 is associated with monilethrix.

KRT83 KRT86

1.28e-052125215744029
Pubmed

HLA-DR2 subtypes form an additional supertypic family of DR beta alleles.

HLA-DRB1 HLA-DRB5

1.28e-05212522885840
Pubmed

Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family.

EPHB3 EPHB4

1.28e-05212527478528
Pubmed

Expression of EphrinB2 and EphB4 in glioma tissues correlated to the progression of glioma and the prognosis of glioblastoma patients.

EPHB2 EPHB4

1.28e-052125222374425
Pubmed

Identification of a new allele, HLA-DRB1*1366*.

HLA-DRB1 HLA-DRB5

1.28e-052125215982265
Pubmed

H2-Eb1 expression is upregulated in the nasal mucosa of allergic rhinitis.

HLA-DRB1 HLA-DRB5

1.28e-052125225543041
Pubmed

Unique sequences for two HLA-DRB1 genes expressed on distinct DRw6 haplotypes.

HLA-DRB1 HLA-DRB5

1.28e-05212521975801
Pubmed

EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling.

EPHB2 EPHB4

1.28e-052125216840724
Pubmed

[A 1:2 matched case-control study on the interaction of HPV16E6 and HLA-DR9 allele to esophageal cancer in Kazakh ethnicity, Xinjiang].

HLA-DRB1 HLA-DRB5

1.28e-052125220193235
Pubmed

ITGA2 as a prognostic factor of glioma promotes GSCs invasion and EMT by activating STAT3 phosphorylation.

ITGA2 STAT3

1.28e-052125238142122
Pubmed

Cell-autonomous role of EphB2 and EphB3 receptors in the thymic epithelial cell organization.

EPHB2 EPHB3

1.28e-052125219731361
Pubmed

MicroRNA alteration and putative target genes in high-grade prostatic intraepithelial neoplasia and prostate cancer: STAT3 and ZEB1 are upregulated during prostate carcinogenesis.

ZEB1 STAT3

1.28e-052125227017949
Pubmed

Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones.

HLA-DRB1 HLA-DRB5

1.28e-05212522986145
Pubmed

Platelet collagen receptor alpha2beta1 integrin and glycoprotein IIIa Pl(A1/A2) polymorphisms are not associated with nephropathy in type 2 diabetes.

ITGA2 ITGA2B

1.28e-052125211728949
Pubmed

TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease.

TFE3 GPNMB

1.28e-052125231043488
Pubmed

A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.

HLA-DRB1 HLA-DRB5

1.28e-05212521085338
Pubmed

A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1.

KRT81 KRT86

1.28e-05212529665406
Pubmed

Involvement of EphB/Ephrin-B signaling in axonal survival in mouse experimental glaucoma.

EPHB2 EPHB3

1.28e-052125222064993
Pubmed

The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth.

EPHB2 EPHB4

1.28e-052125219597185
Pubmed

Complete characterization and sequence of an HLA class II DR beta chain cDNA from the DR5 haplotype.

HLA-DRB1 HLA-DRB5

1.28e-05212523456344
Pubmed

Molecular basis for the defective expression of the mouse Ew17 beta gene.

HLA-DRB1 HLA-DRB5

1.28e-05212522460545
Pubmed

TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation.

TRPV1 STAT3

1.28e-052125227188969
Pubmed

EphB receptors coordinate migration and proliferation in the intestinal stem cell niche.

EPHB2 EPHB3

1.28e-052125216777604
Pubmed

Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-A(k) NOD mice.

HLA-DRB1 HLA-DRB5

1.28e-052125225811933
Pubmed

A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix.

KRT81 KRT86

1.28e-05212529402962
Pubmed

Dysregulation of the EphrinB2-EphB4 ratio in pediatric cerebral arteriovenous malformations is associated with endothelial cell dysfunction in vitro and functions as a novel noninvasive biomarker in patients.

EPHB2 EPHB4

1.28e-052125232286515
Pubmed

A novel HLA-DRB1 allele, DRB1*0707.

HLA-DRB1 HLA-DRB5

1.28e-052125212694577
Pubmed

Limited diversity of HLA-DRB1*02 alleles and DRB1-DRB5 haplotype associations in four United States population groups.

HLA-DRB1 HLA-DRB5

1.28e-052125212694574
Pubmed

circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation.

STAT3 FAT1

1.28e-052125234258151
Pubmed

Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a model of collagen-induced arthritis.

EPHB2 EPHB3

1.28e-052125238558087
Pubmed

H2-EB1 Molecule Alleviates Allergic Rhinitis Symptoms of H2-Eb1 Knockout Mice.

HLA-DRB1 HLA-DRB5

1.28e-052125226714418
Pubmed

Recruitment of multiple alleles within the Eb recombinational hotspot in murine MHC.

HLA-DRB1 HLA-DRB5

1.28e-05212528268654
Pubmed

Carbon fullerenes (C60s) can induce inflammatory responses in the lung of mice.

HLA-DRB1 HLA-DRB5

1.28e-052125220064541
Pubmed

Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell.

TLN1 TLN2

1.28e-052125226822056
Pubmed

The differential expression of EphB2 and EphB4 receptor kinases in normal bladder and in transitional cell carcinoma of the bladder.

EPHB2 EPHB4

1.28e-052125225148033
Pubmed

Extracellular rigidity sensing by talin isoform-specific mechanical linkages.

TLN1 TLN2

1.28e-052125226523364
Pubmed

Silencing of a targeted protein in in vivo platelets using a lentiviral vector delivering short hairpin RNA sequence.

ITGA2B TLN1

1.28e-052125217872456
Pubmed

Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation.

TRPV1 GPNMB

1.28e-052125225392504
Pubmed

EphB receptors, mainly EphB3, contribute to the proper development of cortical thymic epithelial cells.

EPHB2 EPHB3

1.28e-052125229027839
Pubmed

Molecular analysis of the hotspot of recombination in the murine major histocompatibility complex.

HLA-DRB1 HLA-DRB5

1.28e-05212523018929
Pubmed

Sequence analysis of MHC class II Eb cDNAs from H2r and H2p haplotypes.

HLA-DRB1 HLA-DRB5

1.28e-05212528662092
Pubmed

Ancient haplotypes of the HLA Class II region.

HLA-DRB1 HLA-DRB5

1.28e-052125216140993
Pubmed

Molecular mapping of murine I region recombinants. III. Crossing over at two discrete sites within the beta 1-beta 2 intron of the E beta gene.

HLA-DRB1 HLA-DRB5

1.28e-05212521918991
Pubmed

Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex.

EPHB2 EPHB3

1.28e-052125222022561
Pubmed

Characterization of the molecular defects in the mouse E beta f and E beta q genes. Implications for the origin of MHC polymorphism.

HLA-DRB1 HLA-DRB5

1.28e-05212522106558
Pubmed

Platelet receptor HPA-1 polymorphism of alphaIIbbeta3 and 807 C/T polymorphism of alpha2beta1 and Buerger's disease.

ITGA2 ITGA2B

1.28e-052125217495265
Pubmed

Cell type-specific enhancer element associated with a mouse MHC gene, E beta.

HLA-DRB1 HLA-DRB5

1.28e-05212526087163
Pubmed

Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.

EPHB2 EPHB3

1.28e-052125232506584
Pubmed

Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis.

HLA-DRB1 HLA-DRB5

1.28e-052125218832704
Pubmed

EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping.

EPHB2 EPHB3

1.28e-052125212165470
Pubmed

Increased HLA-DR expression and cortical demyelination in MS links with HLA-DR15.

HLA-DRB1 HLA-DRB5

1.28e-052125231882398
Pubmed

Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease.

EPHB2 EPHB4

1.28e-052125234360793
Pubmed

Multiple sites of crossing over within the Eb recombinational hotspot in the mouse.

HLA-DRB1 HLA-DRB5

1.28e-05212521347471
Pubmed

The mouse E beta 2 gene: a class II MHC beta gene with limited intraspecies polymorphism and an unusual pattern of transcription.

HLA-DRB1 HLA-DRB5

1.28e-05212523780666
Pubmed

Platelet P-selectin and GPIIb/IIIa expression after liver transplantation and resection.

SELP ITGA2B

1.28e-052125215316595
Pubmed

The Forgotten: Identification and Functional Characterization of MHC Class II Molecules H2-Eb2 and RT1-Db2.

HLA-DRB1 HLA-DRB5

1.28e-052125226740108
Pubmed

Disturbed Expression of EphB4, but Not EphrinB2, Inhibited Bone Regeneration in an In Vivo Inflammatory Microenvironment.

EPHB2 EPHB4

1.28e-052125228077917
Pubmed

The I-J-disparate mouse strains B10.A(3R) and B10.A(5R) have identical E beta sequences.

HLA-DRB1 HLA-DRB5

1.28e-05212522105907
Pubmed

Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.

EPHB2 EPHB4

1.28e-052125236519465
Pubmed

No evidence for an effect of DNA methylation on multiple sclerosis severity at HLA-DRB1*15 or HLA-DRB5.

HLA-DRB1 HLA-DRB5

1.28e-052125220394989
Pubmed

Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression.

EPHB2 EPHB4

1.28e-052125219366806
Pubmed

Comparison of DR beta 1 alleles from diabetic and normal individuals.

HLA-DRB1 HLA-DRB5

1.28e-05212522884201
Pubmed

A microsatellite-based MHC genotyping system for house mice (Mus domesticus).

HLA-DRB1 HLA-DRB5

1.28e-05212529420473
Pubmed

Myc-Associated Zinc Finger Protein Regulates the Proinflammatory Response in Colitis and Colon Cancer via STAT3 Signaling.

MAZ STAT3

1.28e-052125230181395
Cytoband15q15-q21

TLN2 TP53BP1

4.40e-054125215q15-q21
Cytoband12q13

KRT81 KRT83 KRT85 KRT86

4.42e-0571125412q13
CytobandEnsembl 112 genes in cytogenetic band chr12q13

KRT81 KRT83 KRT85 KRT86 NACA POU6F1 PFKM

1.68e-044231257chr12q13
CytobandEnsembl 112 genes in cytogenetic band chr9q12

SPATA31A7 SPATA31A5

2.04e-0481252chr9q12
Cytoband1p36.1-p35

EPHB2 RAP1GAP

2.61e-04912521p36.1-p35
GeneFamilyKeratins, type II

KRT81 KRT83 KRT85 KRT86

6.07e-0627814609
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHB2 EPHB3 EPHB4

3.04e-05148131095
GeneFamilyCadherin related

DCHS2 CDHR2 FAT1

5.63e-051781324
GeneFamilyMembrane associated guanylate kinases|PDZ domain containing|Scribble complex

LLGL2 LLGL1

1.18e-0448121224
GeneFamilySterile alpha motif domain containing

EPHB2 EPHB3 EPHB4 TNKS

6.55e-0488814760
GeneFamilyFibronectin type III domain containing

EPHB2 EPHB3 EPHB4 NPHS1 FNDC7

7.60e-04160815555
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZHX3 ZEB1

2.00e-0315812529
GeneFamilyCD molecules|Integrin alpha subunits

ITGA2 ITGA2B

2.90e-03188121160
GeneFamilyAnkyrin repeat domain containing

TRPV1 CTTNBP2 PPP1R12A RIPK4 TNKS

4.63e-03242815403
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

EPHB4 SELP BNC2 ZEB1 LPCAT4 JAM2 PLA1A ADGRL2

5.95e-081871258e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCelldroplet-Liver-nan-3m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGIF2 PPP1R12A LPCAT4 ITGA2 PFKM ATF6B TNKS

4.18e-071641257950f87d9dacee45c9004a9bf894543de38f72ee5
ToppCelldroplet-Liver-nan-3m-Lymphocytic-NK/T|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGIF2 PPP1R12A LPCAT4 ITGA2 PFKM ATF6B TNKS

4.18e-071641257c33910a6d87580902e9e7bd27afe6ea63b5eff8d
ToppCelldroplet-Liver-nan-3m-Lymphocytic|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGIF2 PPP1R12A LPCAT4 ITGA2 PFKM ATF6B TNKS

4.18e-071641257bf0d3ad9016a0b8011a2385bb92f0a4f5edad1d6
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM RGS22 MUC5B RYR3 FAT1 ASXL3 TLN2

9.06e-0718412572cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM RGS22 MUC5B RYR3 FAT1 ASXL3 TLN2

9.06e-071841257ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM RGS22 MUC5B RYR3 FAT1 ASXL3 TLN2

9.06e-0718412572b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZEB1 KAT6A SKI STAT3 PASK TAF4B ALG13

1.05e-061881257939790f133eac9c12d08db6ddb5f08f5107844e3
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB4 SELP ZEB1 HLA-DRB1 RYR3 JAM2 PLA1A

1.12e-061901257656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell-(7)_ACKR1+_endothelial_cells|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SELP BNC2 CTTNBP2 ATP10A JAM2 PLA1A ADGRL2

1.43e-061971257143607d195c8aa2b94d995af0b2ef38582565611
ToppCell3'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SELP ZEB1 HLA-DRB1 HLA-DRB5 JAM2 PLA1A ADGRL2

1.58e-062001257cee07d9370656e1c428a7a9e9fbd175129901374
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

EPHB3 PLEKHG4 TFE3 SLC52A3 HMCN2 MGARP

6.09e-06160125619105debef96ea0c267d6a1d332303ec668ae47e
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LPCAT4 ATG14 JAM2 SLC52A3 PASK RECQL5

8.33e-061691256f086b50791e1c93e253eb5e8d6c4bf617b1416c3
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP TCAF1 ZEB1 ITGA2 JAM2 SLC52A3

8.62e-06170125650c6c571591aa4b218caefe5778c570c809f567e
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HEXA SELP SH3BP2 TBC1D10B TLN2 GPNMB

8.62e-0617012567534ac69ca3a378df78d61c284e89bc96a71a4a8
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP TCAF1 ZEB1 ITGA2 JAM2 SLC52A3

8.62e-0617012568fe32dcf924d5f6665f7febbc9647d96b1e96f06
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP TCAF1 ZEB1 ITGA2 JAM2 SLC52A3

8.62e-0617012563232db50b1a40f861e981a1b9c9073b81af9f832
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SELP NCSTN LLGL1 WASHC5 AP5Z1 MVD

9.52e-0617312564968712af1cca8c932abd3323631d7dcaffd4a66
ToppCellAdult-Endothelial-endothelial_cell_of_vein-D231|Adult / Lineage, Cell type, age group and donor

EPHB4 SELP ZEB1 JAM2 PLA1A ADGRL2

9.84e-0617412562dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCellAdult-Endothelial-endothelial_cell_of_vein|Adult / Lineage, Cell type, age group and donor

EPHB4 SELP ZEB1 JAM2 PLA1A ADGRL2

1.05e-051761256043683c61c5d1a7f8a4666a612310246bd3d83a2
ToppCellFF-Differ-KC|World / shred by cell class for mouse tongue

CTTNBP2 KRT81 KRT83 KRT85 KRT86 HHIP

1.16e-0517912561526a130565a97c291a25a7a988089bffc1515c1
ToppCellwk_15-18-Hematologic-Myeloid-APOE+_Mac2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TRPV1 HLA-DRB1 HLA-DRB5 LRRK1 PLA1A GPNMB

1.19e-051801256c630a121aedd09a51ea18cc6e8552eb979e5b555
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KRT81 KRT83 KRT86 ZNF831 ATP10A RHOH

1.39e-051851256e1fd66f4295056807aa29c0e4ce6b1a79cc8dfcf
ToppCellLV-14._Fibroblast_III|World / Chamber and Cluster_Paper

EPHB2 BNC2 ZEB1 STAT3 FAT1 ALG13

1.57e-0518912563922135d1f6fc768d71ba3b465585fead6ea68a8
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP ZEB1 SLC52A3 VSTM4 MANSC1 MTERF2

1.57e-051891256ce5b3d53c9a5457a5a02b221dee18334b5eaf8b7
ToppCelldroplet-Tongue-nan-3m-Epithelial-filiform|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTTNBP2 KRT81 KRT83 KRT85 KRT86 HHIP

1.62e-051901256251e3a33041023bfc4b547c7eb68cfb8f421636f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB4 SELP ZEB1 HLA-DRB1 RYR3 JAM2

1.72e-05192125625cb6cc6cbf8dc20139d938adfc02ed7a8c3dfb6
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

EPHB4 SELP ZEB1 JAM2 PLA1A ADGRL2

1.77e-0519312569ba688b35a9ead5d04691b3f3f15484f02dbbd0d
ToppCellEndothelial-endothelial_cell_of_vein|World / Lineage, Cell type, age group and donor

EPHB4 SELP ZEB1 JAM2 PLA1A ADGRL2

1.82e-0519412563cbd9622a68e89add90e589867d88c83c5a33476
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB4 SELP ZEB1 HLA-DRB1 HLA-DRB5 JAM2

1.82e-051941256fa6d51f36a3dae8763a595c20892987ed454c0f0
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EPHB4 SELP RYR3 JAM2 PLA1A ADGRL2

1.99e-05197125687eda06344498dc66cac292cf89746dc90b5cf67
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SELP ZEB1 HLA-DRB1 HLA-DRB5 JAM2 PLA1A

2.04e-051981256f7aa809040fa9f5782b92eec1f289d690eb5c7bd
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EPHB4 SELP RYR3 JAM2 PLA1A ADGRL2

2.10e-05199125607bda4ac8ffdce1a865ebc99e46c2a27925ff7a8
ToppCellEndothelial_cells-Endothelial-A|Endothelial_cells / lung cells shred on cell class, cell subclass, sample id

SELP HLA-DRB1 HLA-DRB5 PDLIM5 JAM2 ADGRL2

2.10e-0519912562a1424c61ddcd1fea9574f7a3ad1955387458130
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

EPHB4 ZEB1 KAT6A JAM2 RESF1 ADGRL2

2.16e-05200125672ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellTransplant_Alveoli_and_parenchyma-Endothelial-Endothelial|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X

SELP HLA-DRB1 HLA-DRB5 PDLIM5 JAM2 PLA1A

2.16e-0520012562ae62c428728c1d9d4471d4be24bd6ab074fa22c
ToppCellParenchyma_COVID-19-Endothelial-TX|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

EPHB4 SELP ZEB1 JAM2 PLA1A ADGRL2

2.16e-052001256abcbd5a156aa4fd51d284441388975c81c0b88ae
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

EPHB4 ZEB1 KAT6A JAM2 RESF1 ADGRL2

2.16e-0520012565c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell390C-Endothelial_cells-Endothelial-A_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SELP HLA-DRB1 HLA-DRB5 PDLIM5 STAT3 JAM2

2.16e-05200125650b8788494b744e0f0ec8c4d67a1c90ae09dca65
ToppCell390C-Endothelial_cells-Endothelial-A_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SELP HLA-DRB1 HLA-DRB5 PDLIM5 STAT3 JAM2

2.16e-052001256f5f24273bee3259a4a3be99ba53b88defa1286c0
ToppCellLung_Parenchyma-Severe-Endothelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

EPHB4 SELP ZEB1 JAM2 PLA1A ADGRL2

2.16e-052001256d9d0ffa18e5b4647966e19ad9830cbba6120677e
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

EPHB4 SELP ZEB1 JAM2 PLA1A ADGRL2

2.16e-052001256e9d5ba140cabae11c437012d519b85f5412dcc94
ToppCellASK440-Endothelial-Endothelium|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq

SELP HLA-DRB1 HLA-DRB5 JAM2 ADGRL2

2.44e-0512212552f76ec3b527e9528fbb006599a96e8bbdf9e0e62
ToppCellLPS_only-Hematopoietic_Mast-Mast_cells-T-cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF831 RHOH TBC1D10B ACAD8 MGARP

6.55e-051501255ccb782fbcb3122266354a112a9a850506664f44d
ToppCellIIH-CD8-exh_CD4|IIH / Condition, Cell_class and T cell subcluster

KRT86 PFKM ZNF831 RHOH S100PBP

7.42e-051541255a2f51a3c5455fe2483e438375ea856afce8262fe
ToppCellAdult-Endothelial-endothelial_cell_of_vein-D122|Adult / Lineage, Cell type, age group and donor

EPHB4 SELP ZEB1 JAM2 PLA1A

8.88e-0516012550cfe130606af433b2aa90e0a20b6c44659dd6fd4
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HEXA SELP SH3BP2 TBC1D10B GPNMB

9.42e-05162125516d625ac6702f79a83af444d2b3bf6759fd17cf6
ToppCellInfluenza_Severe-cDC|World / Disease group and Cell class

CTTNBP2 RYR3 IFTAP TLN2 TAF4B

9.98e-051641255c984228f73b9aa1aaf948541f64f41ed874770cd
ToppCellClub-club-16|World / Class top

PCDHGB2 PDPK1 KRT86 PDLIM5 PASK

1.03e-041651255684f3c4872bd630d3f744f15d57dccfd34e96160
ToppCellnucseq-Immune-Hematopoietic-Granulocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

BNC2 CTTNBP2 KIAA1549 RYR3 RHOH

1.03e-04165125537615622c736e43260c38016e7c9e565ac97a3e8
ToppCellnucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

BNC2 CTTNBP2 KIAA1549 RYR3 RHOH

1.03e-041651255640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCellnucseq-Immune-Hematopoietic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

BNC2 CTTNBP2 KIAA1549 RYR3 RHOH

1.03e-041651255f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCelldroplet-Lung-nan-3m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGIF2 MAZ RHOH MGARP S100PBP

1.12e-0416812551df3c8c7a6dceb901805eaba7f86f9943f4f1a9d
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D122|Adult / Lineage, Cell type, age group and donor

EPHB4 SELP ZEB1 RYR3 JAM2

1.12e-0416812558c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCelldroplet-Lung-nan-3m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGIF2 MAZ RHOH MGARP S100PBP

1.12e-0416812551586451d437b70b2dffe41d782b694702dcaf50b
ToppCellAdult-Endothelial-endothelial_cell_of_vein-D175|Adult / Lineage, Cell type, age group and donor

SELP ZEB1 JAM2 PLA1A ADGRL2

1.15e-041691255e1f0298236e4a1c59077c14f0dd29a78fac12648
ToppCellNS-critical-d_0-4-Myeloid-Monocyte-derived_DC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

HEXA HLA-DRB1 HLA-DRB5 TLN2 GPNMB

1.15e-0416912556fe82db874eff0f86e5c0d1cc81322eb9d7874eb
ToppCellControl-Mast_cells|Control / group, cell type (main and fine annotations)

BNC2 CTTNBP2 KIAA1549 RYR3 RHOH

1.15e-041691255fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCellCOVID-19-lung-MAST|lung / Disease (COVID-19 only), tissue and cell type

BNC2 CTTNBP2 KIAA1549 RYR3 RHOH

1.18e-041701255e90f18e5462381b38e918442b38b1c8105291908
ToppCellControl-Mast_cells-Mast_cells|Control / group, cell type (main and fine annotations)

BNC2 CTTNBP2 KIAA1549 RYR3 RHOH

1.18e-041701255c80f6d29096c372da95a8407f402349ff1bb7018
ToppCellLPS-IL1RA-Lymphocytic_NKT-T_cells-T-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF831 ATP10A RHOH TBC1D10B TAF4B

1.21e-041711255539ea88acc6f948efdeae8b69e5c5ffaee29f1d9
ToppCellLPS-IL1RA-Lymphocytic_NKT-T_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF831 ATP10A RHOH TBC1D10B TAF4B

1.25e-0417212550fc692be845d4225ff8b63bf9195724fc8510c2c
ToppCellImmune-mast_cell|World / Lineage, Cell type, age group and donor

SELP KIAA1549 ITGA2B RYR3 RHOH

1.25e-0417212556e8e0aac5a20dbc789bf8c6916833bb8709a411a
ToppCellE12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

OSTM1 ITGA2B TRAPPC8 RECQL5 PPP6R2

1.25e-0417212553b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCellT_cells-CD56_bright_CD16-_NK_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

PLEKHG4 KRT81 KRT86 KIAA1549 RYR3

1.25e-041721255980e8b9e1ceeb0dec9eb9ef95c139e5ffe99b6e4
ToppCellHealthy/Control-MAIT|Healthy/Control / Disease group and Cell class

RAP1GAP PRSS38 LPCAT4 ZNF831 RHOH

1.28e-04173125556247c1e07477a8922fe2e3950ae05e2217fd77c
ToppCell3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SELP ZEB1 HLA-DRB5 JAM2 PLA1A

1.28e-041731255b57d14e2c2368304cb903562d06ce8228f53857c
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZHX3 PLEKHG4 ATG2B FHIP2A GPNMB

1.32e-041741255a1f745962a104c6f4b86b7e482da8755384c773a
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-skeletal_muscle_satellite_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS22 RYR3 RHOH TLN2 MGARP

1.32e-041741255f230d23618a6487f2664efb2c677e0a4559e2bf4
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZNF831 CHRM4 RHOH RESF1 MGARP

1.32e-04174125533386750842c47ad7e7286d0f26a556da1a2de02
ToppCellfacs-Lung-24m-Mesenchymal-myofibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP VSTM4 HHIP FAT1 CHD5

1.32e-041741255a7ade7372e83edd4e3983e77f8417b51f0b47340
ToppCellfacs-Lung-24m-Mesenchymal-myofibroblast-myofibroblast_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP ATP10A HHIP CHD5 GPNMB

1.32e-041741255eb8012823b08729b462d1e5212f4873bb6b4eb1e
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-regulatory_T_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZNF831 CHRM4 RHOH RESF1 MGARP

1.32e-0417412559344d4e76d7d9429aea87d3c0b98246200d16014
ToppCellfacs-Lung-24m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP ATP10A HHIP CHD5 GPNMB

1.32e-04174125532fdeeebeeeca657eac6329caad4c28ca54e4d1c
ToppCellCOVID-19-kidney-Podocyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

NPHS1 CTTNBP2 ATP10A RYR3 FAT1

1.35e-041751255a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ZHX3 PLEKHG4 ATG2B FHIP2A GPNMB

1.35e-04175125578a86cac3e6c0d115c997d1c29ee0e24af54551f
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_NKT-T_cells-T-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF831 ATP10A RHOH TBC1D10B TAF4B

1.39e-0417612559d4a4dfeebb5a8a0f3ab18c37c8ddc2cd2158575
ToppCellInt-URO-Lymphocyte-T_NK-gdT|Int-URO / Disease, Lineage and Cell Type

POU6F1 SLC52A3 RHOH LLGL2 PCDHGC3

1.39e-04176125515016a73c953d8d3e7c32a05ead5e7261f9914ca
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_NKT-T_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF831 ATP10A RHOH TBC1D10B TAF4B

1.39e-041761255bb41e9478373726eb460af764de0277b2d09928e
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SELP JAM2 SLC52A3 MANSC1 HMCN2

1.39e-04176125552af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCellLPS-antiTNF-Lymphocytic_NKT-T_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF831 ATP10A RHOH TBC1D10B TAF4B

1.39e-041761255ea27e18407b8a13e8212830da859efeb8f158690
ToppCellLPS-antiTNF-Lymphocytic_NKT-T_cells-T-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF831 ATP10A RHOH TBC1D10B TAF4B

1.39e-041761255bfbab3c5b738b3b0b1540f2059d0245fbd8c0031
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA2 LLGL2 KNDC1 ADGRL2 KNG1

1.43e-041771255c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HEXA HLA-DRB1 HLA-DRB5 ATP10A GPNMB

1.46e-0417812550b398656f26c4061b11ccf98908d0e2e1367585a
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB4 SELP JAM2 SLC52A3 ADGRL2

1.46e-041781255ebfae386a518ea33911ba3ff40464c94d18ef695
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB4 SELP JAM2 SLC52A3 ADGRL2

1.46e-041781255ccd37575b60102f5e647c01546e8ff8fec638bd7
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB4 SELP JAM2 SLC52A3 ADGRL2

1.46e-04178125587b04753650e45f12299c8456fb980d6c0d5961c
ToppCell368C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

EPHB2 PDPK1 KRT86 ACAD8 ARMC5

1.54e-041801255eb5a57604c7f2ad256c300085dbf5069d0ae1ad0
ToppCell368C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

EPHB2 PDPK1 KRT86 ACAD8 ARMC5

1.54e-041801255ddba4dc3bbcfe4e4a22400be73bbc62d3ff27d3c
ToppCellEndothelial-A-HP_01|World / lung cells shred on cell class, cell subclass, sample id

SELP ZEB1 JAM2 PLA1A ADGRL2

1.54e-0418012554c3376169770ee9f9283daae44c17f35e46bfd19
ToppCellsevere-Myeloid-Eosinophils|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

KRT81 ITGA2B PDLIM5 VSTM4 RHOH

1.54e-041801255ac03812b1409435c55d323a7516deeac82bd3509
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-DC-cDC2|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HLA-DRB1 HLA-DRB5 ITGA2B FAT1 HMCN2

1.62e-0418212551d37c486173cc4629842893ddd5033987c04086f
ToppCellT_cells-Resident_memory_CD8+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

EPHB3 CTTNBP2 KRT81 KRT86 ITGA2

1.62e-041821255111d434b89902ec11fb07f41b8ee1a98f3991b61
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-DC-cDC2-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HLA-DRB1 HLA-DRB5 ITGA2B FAT1 HMCN2

1.62e-041821255aef67bdc6937b315522d39959e26c9b0acf7ab52
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-DC|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HLA-DRB1 HLA-DRB5 ITGA2B FAT1 HMCN2

1.62e-041821255087c9f88daf08f5d688b728c2386f91f210d2255
ToppCellwk_08-11-Hematologic_Lymphocytic-T_&_ILC-ILCP|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

KRT81 KRT83 KRT86 ZNF831 RHOH

1.67e-041831255797eb968c57e48db33ff8e2236ee22e9425c4676
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC3_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

KRT81 KRT86 ZNF831 ATP10A RHOH

1.71e-0418412553e9d75af578297950e469f23fb2d28393a2feef8
ToppCellCOVID-19-Endothelial_cells-Arterial_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

SELP ZEB1 JAM2 HMCN2 PLA1A

1.71e-0418412550f19494789f38ab1a420545e15e748ca7eb345c3
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

EPHB2 BNC2 ZEB1 RYR3 VSTM4

1.75e-0418512557dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCellEndothelial-A-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

SELP ZEB1 RYR3 JAM2 PLA1A

1.75e-041851255ae49c61f6ecf128fe2a958b8c75c83688da75f59
DrugRauwolscine hydrochloride [6211-32-1]; Down 200; 10.2uM; PC3; HT_HG-U133A

RAP1GAP SH3BP2 LRRK1 PASK AP5Z1 RECQL5 PPP6R2 CWF19L1 MVD

1.11e-0619712195800_DN
Drug2-acetylfuran

HEXA ITGA2 VPS51

1.45e-0651213CID000014505
DrugGSK-3beta Inhibitor VIII; Up 200; 10uM; PC3; HT_HG-U133A

EPHB4 MTMR1 SKI MANSC1 RECQL5 TMF1 CABIN1 MGA

8.17e-0619012187070_UP
DrugCefoxitin sodium salt [33564-30-6]; Down 200; 8.8uM; HL60; HT_HG-U133A

EPHB2 SLCO3A1 POU6F1 PASK RHOH RECQL5 NUP188 CWF19L1

9.51e-0619412182735_DN
DrugMidodrine hydrochloride [3092-17-9]; Up 200; 13.8uM; PC3; HT_HG-U133A

EPHB3 LPCAT4 ITGA2B TLN1 TLN2 CABIN1 PPP6R2 ALG13

9.88e-0619512182087_UP
DrugPilocarpine nitrate [148-72-1]; Up 200; 14.8uM; MCF7; HT_HG-U133A

SH3BP2 LPCAT4 RIPK4 PASK AP5Z1 TLN1 RECQL5 PPP6R2

1.03e-0519612185341_UP
Drugfluphenazine dihydrochloride; Down 200; 10uM; PC3; HT_HG-U133A

EPHB2 ZEB1 SH3BP2 MAZ MTMR1 PDLIM5 PASK PLA1A

1.06e-0519712184461_DN
DrugBicuculline (+) [485-49-4]; Down 200; 10.8uM; HL60; HT_HG-U133A

EPHB4 BNC2 ZEB1 ITGA2 PASK TLN1 RECQL5 CABIN1

1.10e-0519812182139_DN
Drughaloperidol; Up 200; 10uM; HL60; HT_HG-U133A

EPHB3 ZHX3 SH3BP2 SLCO3A1 ATP10A TLN2 TNKS NUP188

1.10e-0519812186163_UP
DrugMW 1

KRT81 KRT83 KRT86 SKI STAT3 RYR3 KNG1

1.65e-051511217CID000073965
DrugHlamp

SELP ITGA2B PDLIM5

2.34e-05111213CID000195011
Drugmelicopicine

KRT81 KRT83

2.80e-0521212CID000101253
DrugSR 121566

SELP ITGA2B

2.80e-0521212ctd:C106774
Drugtebuquine

KRT81 KRT83

2.80e-0521212CID000071991
Drug3,5-di-O-galloylquinic acid

KRT81 KRT83

2.80e-0521212CID000460896
DrugU121

MGAM ITGA2

2.80e-0521212CID004438528
Drugarteether

KRT81 KRT83 PLA1A

4.03e-05131213CID000072416
DrugHb 7

KRT81 KRT83 KRT85

5.11e-05141213CID000128180
DrugFenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT_HG-U133A

EPHB2 TGIF2 KAT6A SKI PDLIM5 SF3B1 ZFR

7.39e-0519112174279_DN
DrugPHA-00851261E [724719-49-7]; Down 200; 10uM; PC3; HT_HG-U133A

MAZ MTMR1 PASK TLN1 TAF4B CABIN1 PPP6R2

7.63e-0519212174330_DN
DrugDelcorine; Up 200; 8.4uM; PC3; HT_HG-U133A

HEXA ZHX3 CDHR2 KAT6A LRRK1 JAM2 TNKS

7.63e-0519212173715_UP
Drugrosiglitazone maleate; Down 200; 10uM; PC3; HG-U133A

CHRM4 LLGL1 TLN2 PPP6R2 CWF19L1 KNG1 S100PBP

8.15e-051941217430_DN
DrugBetonicine [515-25-3]; Down 200; 25.2uM; PC3; HT_HG-U133A

EPHB2 MAZ MTMR1 ITGA2B PASK TLN1 TLN2

8.15e-0519412174301_DN
DrugMethyl benzethonium chloride [25155-18-4]; Down 200; 8.6uM; PC3; HT_HG-U133A

EPHB2 EPHB3 SH3BP2 MAZ TLN1 RECQL5 CABIN1

8.15e-0519412174325_DN
Drugsulfonamide-3

KRT81 KRT83

8.37e-0531212CID009847197
Drug6-Odbcn

MGAM ITGA2

8.37e-0531212CID000131989
DrugLi2CuCl4

MGAM ITGA2

8.37e-0531212CID000193501
Drug3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Up 200; 13.8uM; PC3; HT_HG-U133A

EPHB2 EPHB4 SH3BP2 KAT6A SKI AP5Z1 RECQL5

8.41e-0519512174298_UP
DrugDiethylcarbamazine citrate [1642-54-2]; Up 200; 10.2uM; HL60; HT_HG-U133A

ZHX3 DCHS2 CDHR2 POU6F1 ATP10A RECQL5 ADGRL2

8.41e-0519512172394_UP
DrugBenzthiazide [91-33-8]; Down 200; 9.2uM; MCF7; HT_HG-U133A

ZHX3 SH3BP2 LPCAT4 RECQL5 TLN2 TAF4B CWF19L1

8.69e-0519612173329_DN
DrugGabazine [105538-73-6]; Up 200; 10.8uM; MCF7; HT_HG-U133A

DCHS2 KRT83 SH3BP2 KAT6A SLCO3A1 MUC5B TP53BP1

8.69e-0519612173253_UP
DrugNialamide [51-12-7]; Down 200; 13.4uM; MCF7; HT_HG-U133A

ZEB1 KRT83 KAT6A SKI AP5Z1 RECQL5 NUP188

8.69e-0519612174347_DN
DrugRetrorsine [480-54-6]; Down 200; 11.4uM; PC3; HT_HG-U133A

EPHB2 EPHB3 MAZ LRRK1 ITGA2B AP5Z1 CWF19L1

8.69e-0519612176601_DN
DrugNapelline [5008-52-6]; Up 200; 11.2uM; MCF7; HT_HG-U133A

EPHB2 ZEB1 CDHR2 KRT83 SH3BP2 KAT6A CHD5

8.69e-0519612176084_UP
DrugEtomidate [33125-97-2]; Up 200; 16.4uM; HL60; HT_HG-U133A

RAP1GAP SLCO3A1 POU6F1 ATP10A PDLIM5 AP5Z1 TLN2

8.69e-0519612172958_UP
Drugtrifluoperazine dihydrochloride; Down 200; 10uM; PC3; HT_HG-U133A

EPHB3 SH3BP2 MTMR1 PDLIM5 PLA1A GPNMB CWF19L1

9.26e-0519812174448_DN
DrugTrichlormethiazide [133-67-5]; Up 200; 10.6uM; MCF7; HT_HG-U133A

EPHB2 EPHB3 KRT83 POU6F1 NUP188 CABIN1 MVD

9.26e-0519812173337_UP
DrugChlorogenic acid [327-97-9]; Up 200; 11.2uM; MCF7; HT_HG-U133A

EPHB2 SH3BP2 MAZ LPCAT4 SKI PDLIM5 MANSC1

9.26e-0519812174142_UP
DrugDeltaline [6836-11-9]; Up 200; 7.8uM; MCF7; HT_HG-U133A

EPHB2 ZEB1 SLCO3A1 ITGA2 AP5Z1 RECQL5 NUP188

9.26e-0519812173831_UP
DrugZidovudine, AZT [30516-87-1]; Up 200; 15uM; HL60; HG-U133A

EPHB4 NCSTN ITGA2B ATP10A CHRM4 TBC1D10B AP5Z1

9.26e-0519812171595_UP
DrugHymecromone [90-33-5]; Down 200; 22.8uM; MCF7; HT_HG-U133A

EPHB4 ZHX3 ZEB1 CDHR2 RIPK4 ITGA2 RECQL5

9.26e-0519812175684_DN
DrugSulindac [38194-50-2]; Down 200; 11.2uM; PC3; HT_HG-U133A

EPHB2 EPHB4 TRPV1 PDPK1 MANSC1 ZFR PPP6R2

9.55e-0519912171815_DN
DrugVancomycin hydrochloride [1404-93-9]; Down 200; 2.6uM; MCF7; HT_HG-U133A

ATG2B LPCAT4 RHOH AP5Z1 RECQL5 NUP188 CWF19L1

9.55e-0519912172858_DN
Drug(+/-)-blebbistatin; Down 200; 17uM; MCF7; HT_HG-U133A_EA

EPHB3 ZHX3 LPCAT4 RIPK4 PASK PPP6R2 MVD

9.55e-051991217954_DN
DrugPhenindione [83-12-5]; Down 200; 18uM; HL60; HG-U133A

SELP TGIF2 PDPK1 LRRK1 RHOH AP5Z1 ZFR

9.55e-0519912171718_DN
DrugATBI

KRT81 KRT83 KRT86

1.13e-04181213CID000505862
DrugSt. Thomas' Hospital cardioplegic solution

SELP ZEB1 CTTNBP2 PFKM PDLIM5 ADGRL2

1.13e-041421216ctd:C041711
DrugCD 86022

HEXA MGAM ADGRL2

1.33e-04191213CID000122617
DrugAC1L9KQO

HEXA KRT81 KRT83 RYR3

1.34e-04491214CID000447335
DrugAdenosine Diphosphate

SELP ITGA2 ITGA2B PFKM

1.56e-04511214ctd:D000244
DrugDBNPA

MGAM ITGA2

1.67e-0441212CID000025059
DrugLactupicrin

KRT81 KRT83

1.67e-0441212CID000174880
Drugisomaltol

SELP ITGA2B

1.67e-0441212CID000018898
Drug2-acetylthiophene

HEXA ITGA2

1.67e-0441212CID000006920
DrugLaI3

MGAM ITGA2

1.67e-0441212CID000083743
Druglactucin

KRT81 KRT83

1.67e-0441212CID000442266
DrugN(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate

SELP ITGA2B

1.67e-0441212ctd:C111914
DiseaseMONILETHRIX

KRT81 KRT83 KRT86

6.40e-0831193158000
DiseaseBeaded hair

KRT81 KRT83 KRT86

6.40e-0831193cv:C0546966
Diseasemonilethrix (is_implicated_in)

KRT81 KRT83 KRT86

6.40e-0831193DOID:0050472 (is_implicated_in)
DiseaseMonilethrix

KRT81 KRT83 KRT86

2.55e-0741193C0546966
DiseaseHantavirus hemorrhagic fever with renal syndrome (is_implicated_in)

HLA-DRB1 HLA-DRB5

1.61e-0521192DOID:11266 (is_implicated_in)
Diseasehair disease (is_implicated_in)

KRT81 KRT86

1.61e-0521192DOID:421 (is_implicated_in)
DiseaseT-Cell Lymphoma

STAT3 ASXL3 MGA

3.45e-05161193C0079772
Diseaseacute disseminated encephalomyelitis (is_implicated_in)

HLA-DRB1 HLA-DRB5

4.83e-0531192DOID:639 (is_implicated_in)
DiseaseGlanzmann's thrombasthenia (is_implicated_in)

ITGA2 ITGA2B

4.83e-0531192DOID:2219 (is_implicated_in)
Diseaseubiquitin carboxyl-terminal hydrolase 25 measurement

HLA-DRB1 HLA-DRB5 ATF6B

9.31e-05221193EFO_0021881
Diseasevon Willebrand's disease 1 (is_implicated_in)

ITGA2 ITGA2B

9.63e-0541192DOID:0060573 (is_implicated_in)
DiseaseCoughing

TRPV1 KNG1

9.63e-0541192C0010200
DiseaseAllergic Reaction

SELP HLA-DRB1 HLA-DRB5 KNG1

1.25e-04631194C1527304
DiseaseHypersensitivity

SELP HLA-DRB1 HLA-DRB5 KNG1

1.33e-04641194C0020517
Diseaseneuroblastoma (implicated_via_orthology)

LLGL2 LLGL1

1.60e-0451192DOID:769 (implicated_via_orthology)
Diseasehepatocyte nuclear factor 4-alpha measurement

HLA-DRB1 HLA-DRB5

1.60e-0451192EFO_0801672
Diseasenephrotic syndrome

NPHS1 HLA-DRB1 HLA-DRB5 NWD2

1.98e-04711194EFO_0004255
DiseaseNeonatal Alloimmune Thrombocytopenia

ITGA2 ITGA2B

2.39e-0461192C3853779
DiseaseFNAITP

ITGA2 ITGA2B

2.39e-0461192C3854603
DiseaseBehcet's disease (is_implicated_in)

HLA-DRB1 ITGA2 STAT3

4.14e-04361193DOID:13241 (is_implicated_in)
Diseaseinterleukin-21 measurement

HLA-DRB1 HLA-DRB5

4.44e-0481192EFO_0801724
Diseasetyrosine-protein kinase receptor TYRO3 measurement

MGAM MGA

4.44e-0481192EFO_0020829
DiseaseEpstein Barr virus nuclear antigen 1 IgG measurement

HLA-DRB1 HLA-DRB5

5.70e-0491192EFO_0007790
Diseaseidiopathic pulmonary fibrosis (is_implicated_in)

HLA-DRB1 MUC5B

5.70e-0491192DOID:0050156 (is_implicated_in)
Diseasecentral nervous system non-hodgkin lymphoma

HLA-DRB1 HLA-DRB5

5.70e-0491192MONDO_0044887
DiseaseHLA class II histocompatibility antigen, DQ alpha 2 chain measurement

HLA-DRB1 HLA-DRB5

5.70e-0491192EFO_0801686
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

ZHX3 HLA-DRB1 STAT3 TNKS TP53BP1

5.78e-041661195EFO_0004530, EFO_0004611
DiseaseCCL19 measurement

HLA-DRB1 HLA-DRB5

7.11e-04101192EFO_0009415
DiseaseMyocardial Ischemia

SELP ZEB1 CTTNBP2 PFKM PDLIM5

7.53e-041761195C0151744
DiseaseBell's palsy

MGAM CDK5RAP3 TAF4B MGA

7.88e-041021194EFO_0007167
Diseaseinsulin sensitivity measurement, response to polyunsaturated fatty acid supplementation

TLN2 ADGRL2

8.66e-04111192EFO_0004471, EFO_0009131
Diseasekidney cancer (implicated_via_orthology)

LLGL2 LLGL1

8.66e-04111192DOID:263 (implicated_via_orthology)
Diseaseanti-Epstein Barr virus antibody measurement

HLA-DRB1 HLA-DRB5

1.04e-03121192EFO_0009273
DiseasePrecursor B-Cell Lymphoblastic Leukemia-Lymphoma

STAT3 MGA

1.04e-03121192C0023485
Diseasetriglyceride measurement, intermediate density lipoprotein measurement

HLA-DRB1 STAT3 PPP6R2 TP53BP1

1.08e-031111194EFO_0004530, EFO_0008595
Diseasecomplement C4 measurement

HLA-DRB1 HLA-DRB5 ATF6B

1.22e-03521193EFO_0004984
DiseaseMammary Carcinoma, Human

EPHB4 ZEB1 PDPK1 STAT3 LLGL2 LLGL1 GPNMB TP53BP1

1.33e-035251198C4704874
DiseaseMammary Neoplasms, Human

EPHB4 ZEB1 PDPK1 STAT3 LLGL2 LLGL1 GPNMB TP53BP1

1.33e-035251198C1257931
DiseaseMalignant neoplasm of breast

EPHB4 RAP1GAP ZEB1 PDPK1 TRAPPC8 STAT3 LLGL2 LLGL1 CHD5 GPNMB HSD17B8 TP53BP1

1.35e-03107411912C0006142
DiseaseMammary Neoplasms

EPHB4 ZEB1 PDPK1 STAT3 LLGL2 LLGL1 GPNMB TP53BP1

1.36e-035271198C1458155
DiseaseC-C motif chemokine 19 measurement

HLA-DRB1 HLA-DRB5

1.42e-03141192EFO_0008047
DiseaseBreast Carcinoma

EPHB4 ZEB1 PDPK1 STAT3 LLGL2 LLGL1 GPNMB TP53BP1

1.55e-035381198C0678222
Diseasefree cholesterol measurement, very low density lipoprotein cholesterol measurement

ZHX3 HLA-DRB1 TNKS PPP6R2 TP53BP1

1.83e-032151195EFO_0008317, EFO_0008591
Diseaseidiopathic dilated cardiomyopathy

MGAM TCAF1 IFTAP

1.85e-03601193EFO_0009094
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

ZHX3 HLA-DRB1 TNKS PPP6R2 TP53BP1

2.02e-032201195EFO_0004529, EFO_0008317
Diseaseanti-anoctamin 2 antibody measurement

HLA-DRB1 HLA-DRB5

2.11e-03171192EFO_0010150
Diseaseresponse to interferon-beta, anti-drug antibody measurement

HLA-DRB1 HLA-DRB5

2.11e-03171192EFO_0010559, GO_0035456
Diseaseovarian neoplasm

BNC2 ZEB1 STAT3 TP53BP1

2.16e-031341194C0919267
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

HLA-DRB1 STAT3 LLGL2 TNKS TP53BP1

2.18e-032241195EFO_0004530, EFO_0008317
DiseaseJuvenile-Onset Still Disease

HLA-DRB1 ITGA2B STAT3 MEX3C

2.22e-031351194C0087031
DiseaseMalignant neoplasm of ovary

BNC2 ZEB1 STAT3 TP53BP1

2.34e-031371194C1140680
Diseaselate-onset myasthenia gravis

HLA-DRB1 HLA-DRB5

2.37e-03181192EFO_1001490
Diseasevery low density lipoprotein cholesterol measurement, phospholipid measurement

ZHX3 HLA-DRB1 TNKS PPP6R2 TP53BP1

2.40e-032291195EFO_0004639, EFO_0008317
Diseasehistidine measurement

PFKM KNG1 TP53BP1

2.43e-03661193EFO_0009769
DiseaseUsual Interstitial Pneumonia

MUC5B STAT3

2.64e-03191192C4721509
DiseaseHamman-Rich Disease

MUC5B STAT3

2.64e-03191192C4721508
Diseaserenal cell carcinoma (is_implicated_in)

HLA-DRB1 STAT3 TFE3

2.76e-03691193DOID:4450 (is_implicated_in)
Diseaseatherosclerosis (biomarker_via_orthology)

SELP STAT3

2.92e-03201192DOID:1936 (biomarker_via_orthology)
DiseaseFamilial Idiopathic Pulmonary Fibrosis

MUC5B STAT3

2.92e-03201192C4721952
Diseasemyocardial infarction

ZHX3 CTTNBP2 SKI ZNF831 PDLIM5 STAT3

3.01e-033501196EFO_0000612
DiseaseTNF-related apoptosis-inducing ligand measurement

TRAPPC8 ASXL3 KNG1

3.11e-03721193EFO_0008300
DiseaseIdiopathic Pulmonary Fibrosis

MUC5B STAT3

3.22e-03211192C1800706
DiseaseHenoch-Schoenlein purpura

HLA-DRB1 HLA-DRB5

3.53e-03221192EFO_1000965
Diseaseprogression free survival, ovarian serous carcinoma

MGAM MGA

3.53e-03221192EFO_0004920, EFO_1001516

Protein segments in the cluster

PeptideGeneStartEntry
NECVTAIEIVPATPA

CHRM4

351

P08173
VAASCANNVPAPVLS

ALG13

851

Q9NP73
AAVAAAVETVTISPP

CHD5

211

Q8TDI0
QPTRAVIFEDCAVPV

ACAD8

241

Q9UKU7
PRFCDIPSQSVEVSQ

ATG14

441

Q6ZNE5
CVSPIQNSAPVSDLT

BNC2

401

Q6ZN30
PTCEITQNTVCSPVD

GPNMB

431

Q14956
VPLPNSVFVNTTESC

SH3BP2

451

P78314
TQCIVVTGSDVFPDP

ADGRL2

101

O95490
LAETVVCNAPSAPVF

ADGRL2

1191

O95490
SCLQDLVSPTVSPAV

ARMC5

706

Q96C12
PSVAQFVLTPSTEVC

AP5Z1

761

O43299
PANCRISVQVATPAL

ATG2B

736

Q96BY7
RTEASVQPVACPQVS

ASXL3

1506

Q9C0F0
TICNTVVVTSPDQPR

ATP10A

576

O60312
TEILPTCNPSTVLTA

NWD2

971

Q9ULI1
APITTVVTTGCEPQC

MUC5B

3561

Q9HC84
PESQATITRCSQPLV

MTMR1

296

Q13613
QTVTIRFPCPVSLDA

IQCN

241

Q9H0B3
IQSTFSINPEIVCDP

NCSTN

236

Q92542
CAACTVPSPQQVLAT

KIAA1549

421

Q9HCM3
VLVQCLPPAAVTAVT

LLGL1

591

Q15334
NECAPVITAVTLSPS

FAT1

251

Q14517
SVDIVCTVDANPILP

NPHS1

756

O60500
ELVPTECQAVTAPVS

PASK

681

Q96RG2
PLEVPQSFCSSSIAV

MAGEB16

61

A2A368
TCQVEHPSVTSPLTV

HLA-DRB5

201

Q30154
VLVQCQPPAVVTSLA

LLGL2

581

Q6P1M3
TASQPCSIVDVEFLP

LPCAT4

256

Q643R3
VVPVAGSCVVDAVPA

EPHB4

216

P54760
VVSSEPVQVCSPVTA

MGA

1581

Q8IWI9
PVQVCSPVTAAVTTT

MGA

1586

Q8IWI9
SPPCITTVSVNESLL

KRT85

91

P78386
TPQQALDTPAVVTCF

LRRK1

1616

Q38SD2
LDTPAVVTCFLAVPV

LRRK1

1621

Q38SD2
TVPCCPTGLTVTQIT

FNDC7

541

Q5VTL7
VLTCDVSGVPAPTVT

HMCN2

3151

Q8NDA2
TGTTPVSAECPVVNE

MGAM

81

O43451
PCITTVSVNESLLTP

KRT86

76

O43790
QLQVIPVPISCSTTD

CWF19L1

416

Q69YN2
CTTIPSAPQAVISSV

EPHB2

321

P29323
NDCAPEVIVTSVSTP

PCDHGB2

341

Q9Y5G2
DELCIPFVVIPATVS

PFKM

516

P08237
PITCSETPTVSQLVS

POU6F1

116

Q14863
PLAAVTCTAPVNIAV

MVD

6

P53602
ENVSALPATVAVASP

MANSC1

221

Q9H8J5
ATAVVAPTSTVAVAP

MAZ

161

P56270
IAPGTCIPNAVEVSV

EPHB3

236

P54753
VTLEVLVAPAVPSCE

JAM2

126

P57087
VNVPRQPTVTSVCSE

PDLIM5

201

Q96HC4
LPSCTVTLELVVENP

PCDHGC3

101

Q9UN70
SVPCSDTVPVIAVSV

OSTM1

276

Q86WC4
VLPVCLATPEVNLTS

PRSS38

166

A1L453
TQPCPSLIDVVVVCD

ITGA2

166

P17301
CPEAIVCSPTAVNTQ

MTERF2

101

Q49AM1
GCPPLSSTAVISIQV

DCHS2

2641

Q6V1P9
CIVPENLPISSTICS

DCHS2

2776

Q6V1P9
FVIILATSQPCQTPD

GPRC6A

11

Q5T6X5
PVSTQACVIEPIVSI

KAT6A

1181

Q92794
FIDSPTVIAVPDLQC

FAM157B

361

P0CG42
CSLPVFLSISVVDQP

CDHR2

221

Q9BYE9
DVSTSIPSCIPFVAQ

IFTAP

131

Q86VG3
TVSTNPAVAVAEPVV

CABIN1

326

Q9Y6J0
LVIPTTIAFCSSINP

CTTNBP2

656

Q8WZ74
PPSVVVSCAGITQDE

HSD17B8

96

Q92506
SVGFVCESPTEQVLP

CDK5RAP3

211

Q96JB5
PEATVAATCAFPSVQ

LDHD

266

Q86WU2
TCQVEHPSVTSPLTV

HLA-DRB1

201

P01911
PSATVVVIKEASACP

MGARP

126

Q8TDB4
TTVPTCQAGPLTIQE

SELP

756

P16109
TLPVIVNIAAAPCDT

KNDC1

1206

Q76NI1
VATQTCQITPAEGPV

KNG1

121

P01042
NLSVTSLPEASVVCP

FHIP2A

241

Q5W0V3
SFGVQPCVSTVLVEP

FBXO30

586

Q8TB52
VTVAPFNPTVCDALL

S100PBP

146

Q96BU1
AVAVPPEATVAITTA

PPP6R2

891

O75170
PCITTVSVNESLLTP

KRT83

81

P78385
PSSEFQISVVDCQPV

NXT1

66

Q9UKK6
VVSVVTPGCNQLPTL

HEXA

96

P06865
TKAPVSVCVEPTASQ

TAF4B

46

Q92750
CVNVTEISDSVPSPV

SLC52A3

166

Q9NQ40
CLTTVPAENATVVPG

SLCO3A1

511

Q9UIG8
ESPITVEVNCTNPGT

TCAF1

526

Q9Y4C2
PVGSTASLCVSQVPA

PLEKHG4

651

Q58EX7
ITTIINCFINSSIPP

RGS22

1076

Q8NE09
VEQNSPAVCETISVP

RESF1

551

Q9HCM1
AVPIQSSVVLCSCPS

PDPK1

11

O15530
LPCTPVLVVATQTDQ

RHOH

106

Q15669
SETQPQVCAAVVLLP

SPATA31A7

1021

Q8IWB4
TPSCPVCQTAVTQAI

MEX3C

641

Q5U5Q3
VIPISCLTEFPNVVQ

RAP1GAP

141

P47736
PVLVSCDSAPCTVVQ

ITGA2B

906

P08514
SEVIIRVTCPLSSPQ

RIPK4

311

P57078
PEECRATVQPAQTLT

HHIP

591

Q96QV1
QQKVVSSPPCAAAVS

SKI

426

P12755
VSVPAPTNVLSLSVC

TGIF2

116

Q9GZN2
VQTKIEPVSPCSSVN

ATF6B

161

Q99941
APCVALTATATPQVQ

RECQL5

186

O94762
PEPVNLQASVTVSCD

PLA1A

436

Q53H76
SETQPQVCAAVVLLP

SPATA31A3

1021

Q5VYP0
TVSIDNPGAVQCPVT

FYTTD1

231

Q96QD9
LVQDQFPVTPVSTLC

VPS51

551

Q9UID3
TPVNCEQPDILVSST

TMF1

401

P82094
TVEQCTSQKIPEIPA

WASHC5

1106

Q12768
VATPAITVSNSCPAE

TFE3

311

P19532
SETQPQVCAAVVLLP

SPATA31A1

1021

Q5TZJ5
SETQPQVCAAVVLLP

SPATA31A5

1021

Q5VU36
DSCPTITVSPVITIQ

TRPV1

71

Q8NER1
QASFIPCPVDTSQVI

RYR3

846

Q15413
IAIVAETCSPFTVLP

SF3B1

1116

O75533
LVACTKVVAPTISSP

TLN1

716

Q9Y490
KVVAPTISSPVCQEQ

TLN1

721

Q9Y490
ICVTPTTCSNTIDLP

STAT3

711

P40763
ICTVAAAPVVPAVST

TNKS

96

O95271
NVSAEVCVPVTLVPV

ZBTB41

801

Q5SVQ8
TTVISPPVDVIASCV

NUP188

601

Q5SRE5
PPVDVIASCVNCLTV

NUP188

606

Q5SRE5
SGTCEAPVAVVTVTP

TBC1D10B

221

Q4KMP7
VFDVVVTDPSCPASV

TP53BP1

1916

Q12888
LPTIVAIADQNSVPC

ZEB1

811

P37275
PAIQSEPETVCNVAI

ZSWIM6

236

Q9HCJ5
SSTVQPVAAAATVVP

ZFR

231

Q96KR1
VSPTISSPVCQEQLI

TLN2

726

Q9Y4G6
QSVQELIPDSFVPCV

TRAPPC8

6

Q9Y2L5
CAALNVTVSPGPVVD

VSTM4

21

Q8IW00
HSVPTQLSTTVECVP

ZNF831

486

Q5JPB2
VECVPVTRSNSLPFV

ZNF831

496

Q5JPB2
KVPEVTCIPTTATLA

ZHX3

581

Q9H4I2
VAPAITTEATAQCIP

KIAA1958

376

Q8N8K9
PCITTVSVNESLLTP

KRT81

76

Q14533
VGTTPLVVTNPCTIA

NACA

436

E9PAV3
LVVTNPCTIAAAPTT

NACA

441

E9PAV3
PCTIAAAPTTTFEVA

NACA

446

E9PAV3
TIPVAPTVVNAAAST

PPP1R12A

631

O14974