Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	volume-sensitive chloride channel activity	TTYH1 TTYH2 TTYH3	9.31e-07	4	124	3	GO:0072320
GeneOntologyMolecularFunction	intracellularly calcium-gated channel activity	TTYH1 TTYH2 TTYH3 ANO6	6.35e-06	20	124	4	GO:0141147
GeneOntologyMolecularFunction	intracellularly calcium-gated chloride channel activity	TTYH1 TTYH2 TTYH3 ANO6	6.35e-06	20	124	4	GO:0005229
GeneOntologyMolecularFunction	volume-sensitive anion channel activity	TTYH1 TTYH2 TTYH3	1.91e-05	9	124	3	GO:0005225
GeneOntologyMolecularFunction	adrenergic receptor activity	ADRA1D ADRA1B ADRB1	2.72e-05	10	124	3	GO:0004935
GeneOntologyMolecularFunction	alpha1-adrenergic receptor activity	ADRA1D ADRA1B	1.14e-04	3	124	2	GO:0004937
GeneOntologyMolecularFunction	Pyrin domain binding	NLRP7 NLRP2	1.14e-04	3	124	2	GO:0032090
GeneOntologyMolecularFunction	G protein-coupled receptor activity	GPR12 OR5D18 MC4R OR6C3 ADGRB3 OR13H1 OR2A5 CHRM1 OR8U8 ADRA1D ADRA1B ADRB1 MRGPRX1 OR7D2 OR13A1 MRGPRX3	1.17e-04	884	124	16	GO:0004930
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	CHRM1 ADRA1D ADRA1B ADRB1	1.20e-04	41	124	4	GO:0008227
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	TTYH1 TTYH2 TTYH3 ANO6	2.62e-04	50	124	4	GO:0099095
GeneOntologyMolecularFunction	alpha-adrenergic receptor activity	ADRA1D ADRA1B	5.65e-04	6	124	2	GO:0004936
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	GPR12 OR5D18 MC4R OR6C3 ADGRB3 OR13H1 OR2A5 ITGA2 CHRM1 OR8U8 ADRA1D ADRA1B ADRB1 MRGPRX1 OR7D2 OR13A1 MRGPRX3 ROS1 MARCO	6.75e-04	1353	124	19	GO:0004888
GeneOntologyMolecularFunction	peptide binding	LVRN MC4R ITGA2 MRGPRX1 MRGPRX3 MARCO GPRASP2 NUP153	8.44e-04	318	124	8	GO:0042277
GeneOntologyMolecularFunction	aspartic-type endopeptidase inhibitor activity	NLRP7 NLRP2	1.34e-03	9	124	2	GO:0019828
GeneOntologyMolecularFunction	neuropeptide binding	MC4R MRGPRX1 MRGPRX3	1.56e-03	37	124	3	GO:0042923
GeneOntologyBiologicalProcess	positive regulation of blood pressure by epinephrine-norepinephrine	ADRA1D ADRA1B ADRB1	7.12e-06	7	123	3	GO:0003321
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by norepinephrine-epinephrine	ADRA1D ADRA1B ADRB1	1.13e-05	8	123	3	GO:0001993
GeneOntologyBiologicalProcess	L-glutamate transmembrane transport	TTYH1 SLC7A13 TTYH2 TTYH3	5.46e-05	35	123	4	GO:0015813
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	GPR12 MC4R ADGRB3 PDE10A CHRM1 ADRA1D ADRA1B ADRB1 MARCO	5.53e-05	286	123	9	GO:0007188
GeneOntologyCellularComponent	microfibril	ADAMTS10 FBN2 FBN3	5.85e-05	13	126	3	GO:0001527
Domain	WD40_repeat_dom	EED WDR5B TAF1C TEP1 WDR26 WDFY4 BRWD3 CFAP52 TENM3 TULP4 CIAO1 TLE2 WDR86 SPAG16	9.95e-09	297	123	14	IPR017986
Domain	WD40_repeat_CS	EED WDR5B TEP1 WDFY4 BRWD3 CFAP52 CIAO1 TLE2 WDR86 SPAG16	1.32e-07	164	123	10	IPR019775
Domain	WD40	EED WDR5B TEP1 WDR26 WDFY4 BRWD3 CFAP52 TULP4 CIAO1 TLE2 WDR86 SPAG16	1.44e-07	259	123	12	PF00400
Domain	WD40	EED WDR5B TEP1 WDR26 WDFY4 BRWD3 CFAP52 TULP4 CIAO1 TLE2 WDR86 SPAG16	2.09e-07	268	123	12	SM00320
Domain	WD40_repeat	EED WDR5B TEP1 WDR26 WDFY4 BRWD3 CFAP52 TULP4 CIAO1 TLE2 WDR86 SPAG16	2.45e-07	272	123	12	IPR001680
Domain	Tweety	TTYH1 TTYH2 TTYH3	2.79e-07	3	123	3	IPR006990
Domain	Tweety	TTYH1 TTYH2 TTYH3	2.79e-07	3	123	3	PF04906
Domain	-	EED WDR5B TAF1C TEP1 WDR26 WDFY4 BRWD3 CFAP52 TULP4 CIAO1 TLE2 WDR86 SPAG16	3.07e-07	333	123	13	2.130.10.10
Domain	WD_REPEATS_1	EED WDR5B TEP1 WDR26 WDFY4 BRWD3 CFAP52 TULP4 CIAO1 TLE2 WDR86 SPAG16	3.09e-07	278	123	12	PS00678
Domain	WD_REPEATS_2	EED WDR5B TEP1 WDR26 WDFY4 BRWD3 CFAP52 TULP4 CIAO1 TLE2 WDR86 SPAG16	3.22e-07	279	123	12	PS50082
Domain	WD_REPEATS_REGION	EED WDR5B TEP1 WDR26 WDFY4 BRWD3 CFAP52 TULP4 CIAO1 TLE2 WDR86 SPAG16	3.22e-07	279	123	12	PS50294
Domain	WD40/YVTN_repeat-like_dom	EED WDR5B TAF1C TEP1 WDR26 WDFY4 BRWD3 CFAP52 TULP4 CIAO1 TLE2 WDR86 SPAG16	3.29e-07	335	123	13	IPR015943
Domain	NACHT	NLRP12 NLRP7 TEP1 NLRP2	1.44e-05	23	123	4	PS50837
Domain	NACHT_NTPase	NLRP12 NLRP7 TEP1 NLRP2	1.44e-05	23	123	4	IPR007111
Domain	ADR_fam	ADRA1D ADRA1B ADRB1	3.23e-05	10	123	3	IPR002233
Domain	GPCR_Rhodpsn_7TM	GPR12 OR5D18 MC4R OR6C3 OR13H1 OR2A5 CHRM1 OR8U8 ADRA1D ADRA1B ADRB1 MRGPRX1 OR7D2 OR13A1 MRGPRX3	3.47e-05	670	123	15	IPR017452
Domain	7tm_1	GPR12 OR5D18 MC4R OR6C3 OR13H1 OR2A5 CHRM1 OR8U8 ADRA1D ADRA1B ADRB1 MRGPRX1 OR7D2 OR13A1 MRGPRX3	3.91e-05	677	123	15	PF00001
Domain	Med12	MED12L MED12	4.30e-05	2	123	2	PF09497
Domain	Mediator_Med12_catenin-bd	MED12L MED12	4.30e-05	2	123	2	IPR021989
Domain	Med12-PQL	MED12L MED12	4.30e-05	2	123	2	PF12144
Domain	Med12-LCEWAV	MED12L MED12	4.30e-05	2	123	2	PF12145
Domain	Med12	MED12L MED12	4.30e-05	2	123	2	SM01281
Domain	Mediator_Med12	MED12L MED12	4.30e-05	2	123	2	IPR019035
Domain	Mediator_Med12_LCEWAV	MED12L MED12	4.30e-05	2	123	2	IPR021990
Domain	G_PROTEIN_RECEP_F1_1	GPR12 OR5D18 MC4R OR6C3 OR13H1 OR2A5 CHRM1 OR8U8 ADRA1D ADRA1B ADRB1 MRGPRX1 OR7D2 OR13A1 MRGPRX3	4.47e-05	685	123	15	PS00237
Domain	G_PROTEIN_RECEP_F1_2	GPR12 OR5D18 MC4R OR6C3 OR13H1 OR2A5 CHRM1 OR8U8 ADRA1D ADRA1B ADRB1 MRGPRX1 OR7D2 OR13A1 MRGPRX3	4.94e-05	691	123	15	PS50262
Domain	GPCR_Rhodpsn	GPR12 OR5D18 MC4R OR6C3 OR13H1 OR2A5 CHRM1 OR8U8 ADRA1D ADRA1B ADRB1 MRGPRX1 OR7D2 OR13A1 MRGPRX3	5.02e-05	692	123	15	IPR000276
Domain	FBN	FBN2 FBN3	1.29e-04	3	123	2	IPR011398
Domain	DAPIN	NLRP12 NLRP7 NLRP2	3.92e-04	22	123	3	PS50824
Domain	PYRIN	NLRP12 NLRP7 NLRP2	3.92e-04	22	123	3	SM01289
Domain	Quino_amine_DH_bsu	TEP1 BRWD3 WDR86	3.92e-04	22	123	3	IPR011044
Domain	PYRIN	NLRP12 NLRP7 NLRP2	3.92e-04	22	123	3	PF02758
Domain	DAPIN	NLRP12 NLRP7 NLRP2	3.92e-04	22	123	3	IPR004020
Domain	ARM-like	RIPOR2 ODAD2 WDFY4 MROH2B STKLD1 HEATR5B MED12 GPRASP2	4.23e-04	270	123	8	IPR011989
Domain	PKD/REJ-like	PKD1L1 KIAA0319L	6.34e-04	6	123	2	IPR002859
Domain	REJ	PKD1L1 KIAA0319L	6.34e-04	6	123	2	PF02010
Domain	7TM_GPCR_Srsx	GPR12 MC4R ADRA1D ADRA1B ADRB1	8.73e-04	112	123	5	SM01381
Domain	TB	FBN2 FBN3	8.84e-04	7	123	2	PF00683
Domain	-	FBN2 FBN3	1.17e-03	8	123	2	3.90.290.10
Domain	TB_dom	FBN2 FBN3	1.50e-03	9	123	2	IPR017878
Domain	PKD/Chitinase_dom	PKD1L1 KIAA0319L	1.50e-03	9	123	2	IPR022409
Domain	TB	FBN2 FBN3	1.50e-03	9	123	2	PS51364
Domain	PKD	PKD1L1 KIAA0319L	1.50e-03	9	123	2	SM00089
Domain	PKD	PKD1L1 KIAA0319L	2.28e-03	11	123	2	PS50093
Domain	PKD_dom	PKD1L1 KIAA0319L	2.28e-03	11	123	2	IPR000601
Domain	MRGPCRFAMILY	MRGPRX1 MRGPRX3	2.28e-03	11	123	2	IPR026234
Domain	-	PKD1L1 KIAA0319L	2.28e-03	11	123	2	2.60.40.670
Domain	-	NLRP12 NLRP7 NLRP2 TNFRSF11B	3.33e-03	93	123	4	1.10.533.10
Domain	-	RIPOR2 ODAD2 WDFY4 MROH2B HEATR5B MED12	3.53e-03	222	123	6	1.25.10.10
Domain	Znf_UBP	USP49 USP45	3.72e-03	14	123	2	IPR001607
Domain	zf-UBP	USP49 USP45	3.72e-03	14	123	2	PF02148
Domain	PLAC	ADAMTS10 ADAMTS17	3.72e-03	14	123	2	PF08686
Domain	ZF_UBP	USP49 USP45	3.72e-03	14	123	2	PS50271
Domain	DEATH-like_dom	NLRP12 NLRP7 NLRP2 TNFRSF11B	4.17e-03	99	123	4	IPR011029
Pathway	REACTOME_ADRENOCEPTORS	ADRA1D ADRA1B ADRB1	2.50e-05	9	96	3	M27302
Pathway	REACTOME_ADRENOCEPTORS	ADRA1D ADRA1B ADRB1	2.50e-05	9	96	3	MM15009
Pathway	WP_MONOAMINE_GPCRS	CHRM1 ADRA1D ADRA1B ADRB1	5.52e-05	31	96	4	MM15871
Pathway	WP_MONOAMINE_GPCRS	CHRM1 ADRA1D ADRA1B ADRB1	7.10e-05	33	96	4	M39585
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	CHRM1 ADRA1D ADRA1B ADRB1	1.85e-04	42	96	4	M5868
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	CHRM1 ADRA1D ADRA1B ADRB1	1.85e-04	42	96	4	MM14971
Pubmed	Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions.	TTYH1 TTYH2 TTYH3	4.76e-08	3	127	3	34385445
Pubmed	A novel human Cl(-) channel family related to Drosophila flightless locus.	TTYH1 TTYH2 TTYH3	4.76e-08	3	127	3	15010458
Pubmed	Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation.	ADRA1D ADRA1B ADRB1	4.76e-08	3	127	3	15598970
Pubmed	Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain.	TTYH1 TTYH2 TTYH3	4.76e-08	3	127	3	31138989
Pubmed	CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.	EED WDR5B WDR26 CIAO1 TLE2	5.51e-08	28	127	5	17041588
Pubmed	Chromosomal organization of adrenergic receptor genes.	ADRA1D ADRA1B ADRB1	4.73e-07	5	127	3	2154750
Pubmed	Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1.	NLRP12 NLRP7 NLRP2	4.73e-07	5	127	3	17046979
Pubmed	The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels.	TTYH1 TTYH2 TTYH3	4.73e-07	5	127	3	18577513
Pubmed	Interaction of neuronal nitric oxide synthase with alpha1-adrenergic receptor subtypes in transfected HEK-293 cells.	ADRA1D ADRA1B ADRB1	9.43e-07	6	127	3	12184796
Pubmed	Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers.	CHRM1 ADRA1D ADRA1B ADRB1	2.02e-06	25	127	4	19855129
Pubmed	PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing.	NLRP12 NLRP7 NLRP2	2.63e-06	8	127	3	12019269
Pubmed	Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.	ADRA1D ADRA1B ADRB1	2.63e-06	8	127	3	9139936
Pubmed	Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo.	ADRA1D ADRA1B ADRB1	3.93e-06	9	127	3	21209093
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DIP2B RTEL1 JADE2 TTYH3 PDE10A TEP1 TTC3 BRWD3 PTK2 STT3A ASAP2 NADSYN1 TULP4 SYNJ2 CDK13 SCAF11 FGGY CPNE7	8.19e-06	1489	127	18	28611215
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	DIP2B KIAA0319L CBARP ITGA2 PARP14 SYT7 ATP10D ADRA1B ANO6 SIGLEC6 NRK	8.21e-06	569	127	11	30639242
Pubmed	Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes.	ADRA1D ADRA1B	1.32e-05	2	127	2	10820200
Pubmed	NLRP2 controls age-associated maternal fertility.	NLRP7 NLRP2	1.32e-05	2	127	2	27881734
Pubmed	NLRP2 is highly expressed in a mouse model of ischemic stroke.	NLRP7 NLRP2	1.32e-05	2	127	2	27693696
Pubmed	Homozygosity mapping of a Weill-Marchesani syndrome locus to chromosome 19p13.3-p13.2.	ADAMTS10 FBN3	1.32e-05	2	127	2	11941487
Pubmed	Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not Improved by IVF or Embryo Transfer Consistent with Oocyte-Specific Defect.	NLRP7 NLRP2	1.32e-05	2	127	2	33090377
Pubmed	Activation of focal adhesion kinase via M1 muscarinic acetylcholine receptor is required in restitution of intestinal barrier function after epithelial injury.	CHRM1 PTK2	1.32e-05	2	127	2	24365239
Pubmed	Clinical implications from studies of alpha1 adrenergic receptor knockout mice.	ADRA1D ADRA1B	1.32e-05	2	127	2	17141736
Pubmed	Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors.	ADRA1D ADRA1B	1.32e-05	2	127	2	14736874
Pubmed	A genetic association study of NLRP2 and NLRP7 genes in idiopathic recurrent miscarriage.	NLRP7 NLRP2	1.32e-05	2	127	2	23360675
Pubmed	The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels.	TTYH1 TTYH3	1.32e-05	2	127	2	16219661
Pubmed	TTYH family members form tetrameric complexes at the cell membrane.	TTYH2 TTYH3	1.32e-05	2	127	2	36042377
Pubmed	N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2).	TTYH2 TTYH3	1.32e-05	2	127	2	18260827
Pubmed	Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice.	ADRA1D ADRB1	1.32e-05	2	127	2	26203906
Pubmed	Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization.	TTYH2 TTYH3	1.32e-05	2	127	2	34824283
Pubmed	Nlrp2, a maternal effect gene required for early embryonic development in the mouse.	NLRP7 NLRP2	1.32e-05	2	127	2	22295082
Pubmed	TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma.	TTYH1 TTYH2	1.32e-05	2	127	2	11597145
Pubmed	Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism involving inflammation and oxidative stress.	NLRP7 NLRP2	1.32e-05	2	127	2	30454891
Pubmed	NLRP2 inflammasome in dorsal root ganglion as a novel molecular platform that produces inflammatory pain hypersensitivity.	NLRP7 NLRP2	1.32e-05	2	127	2	31162334
Pubmed	Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature.	ADAMTS10 ADAMTS17	1.32e-05	2	127	2	19836009
Pubmed	Evidence for the presence of alpha1 adrenoceptor subtypes in the human ureter.	ADRA1D ADRA1B	1.32e-05	2	127	2	15690361
Pubmed	The genetics of NOD-like receptors in Crohn's disease.	NLRP12 NLRP7 NLRP2	1.68e-05	14	127	3	20403135
Pubmed	NALPs: a novel protein family involved in inflammation.	NLRP12 NLRP7 NLRP2	1.68e-05	14	127	3	12563287
Pubmed	The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression.	WNT11 WNT5B FUT4	1.68e-05	14	127	3	17055474
Pubmed	Identification of a novel family of G protein-coupled receptor associated sorting proteins.	CHRM1 ADRB1 GPRASP2	1.68e-05	14	127	3	15086532
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	ADAMTS10 FBN2 ADAMTS17	3.73e-05	18	127	3	35503090
Pubmed	Gene expressions and mechanical functions of α1-adrenoceptor subtypes in mouse ureter.	ADRA1D ADRA1B	3.96e-05	3	127	2	19259685
Pubmed	Mosaic moles and non-familial biparental moles are not caused by mutations in NLRP7, NLRP2 or C6orf221.	NLRP7 NLRP2	3.96e-05	3	127	2	22909446
Pubmed	Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B.	NLRP7 NLRP2	3.96e-05	3	127	2	36976514
Pubmed	Apoptosis Signal-regulating Kinase 1 Silencing on Astroglial Inflammasomes in an Experimental Model of Ischemic Stroke.	NLRP7 NLRP2	3.96e-05	3	127	2	30172704
Pubmed	The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.	ADRA1D ADRA1B	3.96e-05	3	127	2	8183249
Pubmed	Maternal variants in NLRP and other maternal effect proteins are associated with multilocus imprinting disturbance in offspring.	NLRP7 NLRP2	3.96e-05	3	127	2	29574422
Pubmed	Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery.	ADRA1D ADRA1B	3.96e-05	3	127	2	17384126
Pubmed	Role of α₁-adrenoceptor subtypes in pupil dilation studied with gene-targeted mice.	ADRA1D ADRA1B	3.96e-05	3	127	2	25425303
Pubmed	Localizations and expressions of alpha-1A, alpha-1B and alpha-1D adrenoceptors in human ureter.	ADRA1D ADRA1B	3.96e-05	3	127	2	17973108
Pubmed	Role of Noncanonical Wnt Signaling Pathway in Human Aortic Valve Calcification.	WNT11 WNT5B	3.96e-05	3	127	2	27932350
Pubmed	HLA-C expression in extravillous trophoblasts is determined by an ELF3-NLRP2/NLRP7 regulatory axis.	NLRP7 NLRP2	3.96e-05	3	127	2	39052836
Pubmed	Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation.	MRGPRX1 MRGPRX3	3.96e-05	3	127	2	28768771
Pubmed	The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.	MRGPRX1 MRGPRX3	3.96e-05	3	127	2	26022362
Pubmed	Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways.	MRGPRX1 MRGPRX3	3.96e-05	3	127	2	27215903
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	ADAMTS10 FBN2	3.96e-05	3	127	2	30201140
Pubmed	Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2/β5/FAK signaling pathway.	ITGA2 PTK2	3.96e-05	3	127	2	26758421
Pubmed	Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.	ADRA1D ADRA1B	3.96e-05	3	127	2	8024574
Pubmed	Alpha1-adrenoceptors are required for normal male sexual function.	ADRA1D ADRA1B	3.96e-05	3	127	2	17603545
Pubmed	Examination of alpha 1 adrenoceptor subtypes in the human ureter.	ADRA1D ADRA1B	3.96e-05	3	127	2	17681068
Pubmed	Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs.	MRGPRX1 MRGPRX3	3.96e-05	3	127	2	11850634
Pubmed	The alpha(1B)-adrenergic receptor decreases the inotropic response in the mouse Langendorff heart model.	ADRA1D ADRA1B	3.96e-05	3	127	2	14659805
Pubmed	The presence and distribution of alpha adrenergic receptors in human renal pelvis and calyces.	ADRA1D ADRA1B	3.96e-05	3	127	2	23877383
Pubmed	Uncoupling of Pyrin-only protein 2 (POP2)-mediated dual regulation of NF-κB and the inflammasome.	NLRP7 NLRP2	3.96e-05	3	127	2	21976665
Pubmed	Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function.	NLRP7 NLRP2	3.96e-05	3	127	2	37499769
Pubmed	Overexpression of Eukaryotic translation initiation factor 3D induces stem cell-like properties and metastasis in cervix cancer by activating FAK through inhibiting degradation of GRP78.	PTK2 EIF3D	3.96e-05	3	127	2	35104170
Pubmed	Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse.	ADRA1D ADRA1B	3.96e-05	3	127	2	7595531
Pubmed	Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR.	ADRA1D ADRA1B	3.96e-05	3	127	2	12595294
Pubmed	Functional role of α1-adrenoceptor subtypes in murine ophthalmic arteries.	ADRA1D ADRA1B	3.96e-05	3	127	2	21613371
Pubmed	Autonomous expression of aromatase during development of mouse brain is modulated by neurotransmitters.	ADRA1D ADRA1B	3.96e-05	3	127	2	9365205
Pubmed	Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.	ADRA1B ADRB1	3.96e-05	3	127	2	22723743
Pubmed	Up-regulation of α1-adrenoceptors in burn and keloid scars.	ADRA1D ADRA1B	3.96e-05	3	127	2	29089212
Pubmed	bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells.	MRGPRX1 MRGPRX3	3.96e-05	3	127	2	10662793
Pubmed	No evidence for mutations in NLRP7, NLRP2 or KHDC3L in women with unexplained recurrent pregnancy loss or infertility.	NLRP7 NLRP2	3.96e-05	3	127	2	25376457
Pubmed	Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.	ADRA1D ADRA1B	3.96e-05	3	127	2	7815325
Pubmed	Role of α1-adrenoceptor subtypes on corneal epithelial thickness and cell proliferation in mice.	ADRA1D ADRA1B	3.96e-05	3	127	2	30257104
Pubmed	Evidence of alpha1-adrenoceptor functional changes in omental arteries of patients with end-stage renal disease.	ADRA1D ADRA1B	3.96e-05	3	127	2	18257748
Pubmed	Specific interactions between gC1qR and alpha1-adrenoceptor subtypes.	ADRA1D ADRA1B	3.96e-05	3	127	2	14626446
Pubmed	Human RTEL1 Interacts with KPNB1 (Importin β) and NUP153 and Connects Nuclear Import to Nuclear Envelope Stability in S-Phase.	RTEL1 NUP153	3.96e-05	3	127	2	38132118
Pubmed	Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes.	ADRA1D ADRA1B	3.96e-05	3	127	2	15297446
Pubmed	Alpha1-adrenoceptor-dependent vascular hypertrophy and remodeling in murine hypoxic pulmonary hypertension.	ADRA1D ADRA1B	3.96e-05	3	127	2	17220188
Pubmed	Asymmetrical ligand-induced cross-regulation of chemokine (C-X-C motif) receptor 4 by α1-adrenergic receptors at the heteromeric receptor complex.	ADRA1D ADRA1B	3.96e-05	3	127	2	29426850
Pubmed	Neuron-glia signaling via alpha(1) adrenoceptor-mediated Ca(2+) release in Bergmann glial cells in situ.	ADRA1D ADRA1B	3.96e-05	3	127	2	10493741
Pubmed	Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions.	MRGPRX1 MRGPRX3	3.96e-05	3	127	2	18250432
Pubmed	Norepinephrine suppresses gonadotropin-releasing hormone neuron excitability in the adult mouse.	ADRA1D ADRB1	3.96e-05	3	127	2	18079196
Pubmed	Mas-related G protein-coupled receptor C11 (Mrgprc11) induces visceral hypersensitivity in the mouse colon: A novel target in gut nociception?	MRGPRX1 MRGPRX3	3.96e-05	3	127	2	31119828
Pubmed	NLRP2 and FAF1 deficiency blocks early embryogenesis in the mouse.	NLRP7 NLRP2	3.96e-05	3	127	2	28630100
Pubmed	alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1.	ADRA1D ADRA1B	3.96e-05	3	127	2	12409310
Pubmed	Gene body hypomethylation of pyroptosis-related genes NLRP7, NLRP2, and NLRP3 facilitate non-invasive surveillance of hepatocellular carcinoma.	NLRP7 NLRP2	3.96e-05	3	127	2	37273114
Pubmed	Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution.	ADRA1D ADRA1B ADRB1	6.03e-05	21	127	3	1676978
Pubmed	Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α1-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays.	ADRA1D ADRA1B	7.90e-05	4	127	2	32085899
Pubmed	Experimental and computational approaches yield a high-resolution, 1-Mb physical map of the region harboring the mouse t haplotype sterility factor, tcs1.	TULP4 SYNJ2	7.90e-05	4	127	2	11471064
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN2 FBN3	7.90e-05	4	127	2	25034023
Pubmed	MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model.	MRGPRX1 MRGPRX3	7.90e-05	4	127	2	29064954
Pubmed	Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent.	ADRA1B ADRB1	7.90e-05	4	127	2	28219977
Pubmed	Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.	MRGPRX1 MRGPRX3	7.90e-05	4	127	2	33727332
Pubmed	A fraction of mouse sperm chromatin is organized in nucleosomal hypersensitive domains enriched in retroposon DNA.	MRGPRX1 MRGPRX3	7.90e-05	4	127	2	10504302
Pubmed	Weill-Marchesani Syndrome	ADAMTS10 ADAMTS17	7.90e-05	4	127	2	20301293
Pubmed	Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis.	CHRM1 PTK2	7.90e-05	4	127	2	32205868
Pubmed	A mechanically activated ion channel is functionally expressed in the MrgprB4 positive sensory neurons, which detect stroking of hairy skin in mice.	MRGPRX1 MRGPRX3	7.90e-05	4	127	2	28545921
Pubmed	Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses.	NLRP7 NLRP2	7.90e-05	4	127	2	22750073
Cytoband	13q12	GPR12 SACS LHFPL6	4.01e-05	24	127	3	13q12
GeneFamily	WD repeat domain containing	EED WDR5B TEP1 WDR26 WDFY4 BRWD3 CFAP52 TULP4 CIAO1 TLE2 WDR86 SPAG16	1.60e-08	262	97	12	362
GeneFamily	Adrenoceptors	ADRA1D ADRA1B ADRB1	1.23e-05	9	97	3	169
GeneFamily	NLR family	NLRP12 NLRP7 NLRP2	3.16e-04	25	97	3	666
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP12 NLRP7 NLRP2	3.16e-04	25	97	3	994
GeneFamily	Cyclins\|Mediator complex	MED24 MED12L MED12	7.27e-04	33	97	3	1061
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	NLRP7 ADGRB3 WDFY4 SIGLEC6 MED12L LHFPL6 WDR86	5.19e-07	168	126	7	968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCell	COVID-mDC1-\|COVID / Condition, Cell_class and T cell subcluster	USP49 BTLA WDFY4 PTK2 TNFRSF11B MED12L LHFPL6	6.83e-07	175	126	7	83a95d6fc2ddf3ec53f05825bbc982fb8d2ccd15
ToppCell	COVID-mDC1\|COVID / Condition, Cell_class and T cell subcluster	USP49 BTLA WDFY4 PTK2 TNFRSF11B MED12L LHFPL6	6.83e-07	175	126	7	b9280444016e21c28131a61df65cc5c56d402412
ToppCell	E16.5-samps-Mesenchymal-Pericyte\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CYP20A1 TNFRSF11B ADRA1D LGI2 LHFPL6 FUT4	4.07e-06	148	126	6	e697a7fb037873c9b11703d1bf836a69fc276e23
ToppCell	E16.5-samps-Mesenchymal-Pericyte-pericyte_A\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CYP20A1 TNFRSF11B ADRA1D LGI2 LHFPL6 FUT4	4.07e-06	148	126	6	c87fe2373418ec0cfe37279003d1c4df4c0d0aac
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|World / disease group, cell group and cell class (v2)	NLRP7 ADGRB3 WDFY4 SIGLEC6 MED12L WDR86	8.15e-06	167	126	6	bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RIPOR2 DGKD ADRA1B LGI2 FBN3 CPNE7	1.33e-05	182	126	6	420a8fd30543e37a66ba0786215d056d308660d0
ToppCell	droplet-Lung-30m-Mesenchymal-myofibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TTYH1 WNT11 TNFRSF11B WNT5B ADRA1B LHFPL6	1.41e-05	184	126	6	55dde9c4eebac2a33788c1ff1d8fe312d150fad4
ToppCell	droplet-Lung-30m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TTYH1 WNT11 TNFRSF11B WNT5B ADRA1B LHFPL6	1.41e-05	184	126	6	7128a2be291544d3df3ed6c80f21ddda8437dcba
ToppCell	droplet-Lung-30m-Mesenchymal-myofibroblast-pericyte_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TTYH1 WNT11 TNFRSF11B WNT5B ADRA1B LHFPL6	1.41e-05	184	126	6	d14238f7b0b55a4c8d7040bea854bd221a66ac30
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYP20A1 TTYH2 PTK2 TNFRSF11B WNT5B LHFPL6	1.65e-05	189	126	6	26cfe5b7e7f477f225f4e9f25f983f432f01e183
ToppCell	(2)_Fibroblasts-(22)_Fibro-3\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	TTYH1 PRSS12 BTLA FBN2 TENM3 LHFPL6	1.70e-05	190	126	6	3aed03b87ba2c8d479048c3ceef3ff5e38746c28
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RIPOR2 PRSS12 DGKD FBN2 TLE2 CPNE7	1.70e-05	190	126	6	3b8d1e66ae68c1eee64095e75195d76d97e24026
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RIPOR2 PRSS12 DGKD FBN2 TLE2 CPNE7	1.70e-05	190	126	6	dc655e4782aab274f0c9b6e36a5ce315e3a1a4b9
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADGRB3 PDE10A TENM3 SYNJ2 ADAMTS17 WDR86	1.75e-05	191	126	6	08720998aa55131d7377c4c67c4c935865bd7d79
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA2 CHRM1 SYT7 EHD4 ADAMTS17 FUT4	1.85e-05	193	126	6	6a9bce5064938b5b84ad57b4fd4a7841afe100c8
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACLY TTYH2 SYT7 SOCS2 TENM3 ACOT11	1.96e-05	195	126	6	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	WNT11 TTC3 SOCS2 ADAMTS10 FBN2 LHFPL6	2.02e-05	196	126	6	f0fd7db22985d2bc84dc8bcbdb2d552e280121dd
ToppCell	(2)_Fibroblasts-(22)_Fibro-3\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	TTYH1 PRSS12 BTLA SOCS2 FBN2 TENM3	2.08e-05	197	126	6	d9021bab82403e566ec10f78acb227c0f80b88fe
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GPR12 PDE10A ADAMTS10 WNT5B WDR86 HSD17B2	2.14e-05	198	126	6	fab3135f03cf23a9f04f0eed543a9dc181f39f5f
ToppCell	COVID-19-COVID-19_Mild-Myeloid-immature_Neutrophil\|COVID-19_Mild / Disease, condition lineage and cell class	DNAH3 PKD1L1 FBN2 RAD54B FUT4 ESPL1	2.20e-05	199	126	6	e222b90caf45904d8f763574e7b6aac13333df92
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GPR12 PDE10A ADAMTS10 WNT5B WDR86 HSD17B2	2.26e-05	200	126	6	b992eeddee38e6fe3564e9b1850f6b20b89bf47d
ToppCell	Sepsis-Int-URO-Myeloid-cDC1\|Int-URO / Disease, condition lineage and cell class	USP45 BTLA WDFY4 PTK2 SLC46A3 FGGY	2.26e-05	200	126	6	77479f733cc4ce62a07ab33d5dc2d41c911c74fc
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-MyoFB-3\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	WNT5B FBN2 TENM3 OR13A1 GPRASP2	4.12e-05	135	126	5	5b13ff740d9f7d96274aebb6b389a80f6004adc7
ToppCell	Substantia_nigra-Macroglia-CSF_related\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DNAH3 ODAD2 CFAP52 GLIPR1L1 SPAG16	4.27e-05	136	126	5	47663c5d81c766a333207a44fc5b58b07309ee76
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DNAH3 ODAD2 CFAP52 GLIPR1L1 SPAG16	4.27e-05	136	126	5	6d2e5b871f4cf8d64e6fe0be666fb3490797c635
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DNAH3 ODAD2 CFAP52 GLIPR1L1 SPAG16	4.27e-05	136	126	5	fd4269d194c7c11c6ab4383393a01efab05cbace
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DNAH3 ODAD2 CFAP52 GLIPR1L1 SPAG16	4.27e-05	136	126	5	3f6cec8d52c84191f7f6e2dd4dc47524dfd5b21b
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DNAH3 ODAD2 CFAP52 GLIPR1L1 SPAG16	4.27e-05	136	126	5	67d736096d6b6ddb4722809557f5e987063b8d23
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CSMD2 LIMS2 ADRA1D LGI2 WDR86	5.98e-05	146	126	5	2ac9b487a7991fdc15444aeb93533030e09825bb
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RIPOR2 TTYH2 BTLA WDFY4 MED12L	9.78e-05	162	126	5	86a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCell	Int-URO-Myeloid-cDC1\|Int-URO / Disease, Lineage and Cell Type	USP45 BTLA WDFY4 PTK2 FGGY	1.04e-04	164	126	5	f4628a7ff0dc765a5337ab499b3d61fc25573a16
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL PRSS12 ODAD2 CHRM1 CFAP52	1.04e-04	164	126	5	9e16e52f5a634585f26021bcce9b5d5992ff6db0
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	WDR5B JADE2 ATP10D LGI2 LHFPL6	1.10e-04	166	126	5	65dafed953b01a9830b54309af75c7a561e88336
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIP2B RIPOR2 RTEL1 BTLA MARCO	1.10e-04	166	126	5	6a948aefd283a2572da37b59dbc142b6e686b024
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIP2B RIPOR2 RTEL1 BTLA MARCO	1.10e-04	166	126	5	8d0c4eb90a2c006f96ae61d3d94c96fb64bc0c4d
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR12 XKR6 PDE10A CHRM1 TENM3	1.16e-04	168	126	5	b87fc63f9e35dfcfc46cb129ea569e73c5e018bb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR12 XKR6 PDE10A CHRM1 TENM3	1.16e-04	168	126	5	b96a48552f4236a95bbcdce2f1b05041086d7101
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	BTLA RAD54B LHFPL6 WDR86 FUT4	1.19e-04	169	126	5	625788d86f0ceebcf2653a251db1f1a9f9746d29
ToppCell	BL-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CEL WNT11 TNFRSF11B TENM3 LGI2	1.23e-04	170	126	5	b465df2dac6b4e98b4ede6ad0c6347656757885c
ToppCell	Influenza_Severe-B_intermediate\|World / Disease group and Cell class	WDFY4 PTK2 LIMS2 SIGLEC6 MED12L	1.26e-04	171	126	5	4d33e1dc1efc423dbdd5f4cca6d6440a68add8d0
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GPR12 PRSS12 ODAD2 TNFRSF11B WNT5B	1.33e-04	173	126	5	09a13407a41ff2cba82fc417b72bf9a24ce6c42e
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GPR12 PRSS12 ODAD2 TNFRSF11B WNT5B	1.33e-04	173	126	5	bfec038a6783f166240da4861e100643c6ea80a5
ToppCell	droplet-Lung-nan-21m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BTLA WDFY4 SLC46A3 MED12L WDR86	1.37e-04	174	126	5	2afa5eea54b67c549c5058ece98296eee3829c11
ToppCell	facs-Heart-RV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTYH2 ADRA1D ADAMTS17 LHFPL6 WDR86	1.40e-04	175	126	5	bfac175b79bb7d3d81074a2407c206a7647ee75d
ToppCell	facs-Heart-RV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTYH2 ADRA1D ADAMTS17 LHFPL6 WDR86	1.40e-04	175	126	5	c94fb35bbac95123201ca87ca835aecaefc0c490
ToppCell	E12.5-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RIPOR2 PRSS12 PTK2 EHD4 LHFPL6	1.48e-04	177	126	5	5cdf413f82376a95467322b16d10b0d1e7557e2d
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	USP49 TENM3 LGI2 NRK LHFPL6	1.48e-04	177	126	5	30f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCell	3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TTYH1 GPR12 SYT7 SYNJ2 FGGY	1.56e-04	179	126	5	ec331b1132f965581f851a3b29e62873c4140e6c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_RORB_CARTPT\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRSS12 MED12L LHFPL6 ROS1 WDR86	1.60e-04	180	126	5	5e78b29fa1cbdcf502fee3577e5b45766b90d1dc
ToppCell	11.5-Distal-Immune-Immune\|Distal / Age, Tissue, Lineage and Cell class	RIPOR2 TDRD9 BTLA WDFY4 SIGLEC6	1.64e-04	181	126	5	193ee02f547a218b2fc13e1174ea4cff4f8a3450
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	CYP20A1 TTYH2 FBN2 TENM3 GPRASP2	1.69e-04	182	126	5	812dac35b9aa05be48258082e007f6c00e7b4dd8
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DGKD ADRA1D FBN2 LHFPL6 WDR86	1.73e-04	183	126	5	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA2 XKR6 ASAP2 ACOT11 NRK	1.73e-04	183	126	5	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ODAD2 CHRM1 FBN2 NRK ROS1	1.77e-04	184	126	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RIPOR2 PRSS12 DGKD FBN2 WDR86	1.77e-04	184	126	5	e2de27cee3ea80f9b7a9a7884ceceeaa67b3214a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ODAD2 CHRM1 FBN2 NRK ROS1	1.77e-04	184	126	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ODAD2 CHRM1 FBN2 NRK ROS1	1.77e-04	184	126	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-Bergmann_glial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTYH1 TTYH3 MLC1 ACOT11 SPAG16	1.77e-04	184	126	5	f6148e9591e8845cc62668e49fd52755257cdc7e
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADGRB3 TNFRSF11B FBN2 TENM3 NRK	1.82e-04	185	126	5	8ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADGRB3 TNFRSF11B FBN2 TENM3 NRK	1.82e-04	185	126	5	b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell	PBMC-Control-cDC_10\|Control / Compartment, Disease Groups and Clusters	ODAD2 TNFRSF11B SOCS2 WNT5B WDR86	1.82e-04	185	126	5	4b5a7450fed912f340da16065c1e65d626dbe8d1
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TTYH1 FBN2 TENM3 NRK ADAMTS17	1.86e-04	186	126	5	4d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CSMD2 TNFRSF11B LIMS2 LGI2 LHFPL6	1.86e-04	186	126	5	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ODAD2 WNT5B FBN2 TENM3 SYNJ2	1.96e-04	188	126	5	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ODAD2 WNT5B FBN2 TENM3 SYNJ2	1.96e-04	188	126	5	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACLY TTYH2 TTC3 TENM3 ACOT11	1.96e-04	188	126	5	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA2 XKR6 ACOT11 ADAMTS17 MED12L	2.01e-04	189	126	5	977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA2 XKR6 ASAP2 NRK ADAMTS17	2.01e-04	189	126	5	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKD TENM3 LGI2 TLE2 ADAMTS17	2.01e-04	189	126	5	99a13b1b669b0cd36e3096632351d9ade25d1173
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA2 XKR6 ASAP2 NRK ADAMTS17	2.01e-04	189	126	5	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	CTRL-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	RIPOR2 DGKD PARP14 WDFY4 PTK2	2.01e-04	189	126	5	14f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTYH1 CHRM1 SYT7 EHD4 ADAMTS17	2.01e-04	189	126	5	5a0fd34928117f162c83ca1b068aa8f7069a6765
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYP20A1 TTYH2 PTK2 WNT5B LHFPL6	2.06e-04	190	126	5	2ab604d35456beba71c25511e0f819000e6642d2
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GPR12 PRSS12 DGKD FBN2 TLE2	2.06e-04	190	126	5	59720dfe9de1b980807644536c919d2a02ba69dd
ToppCell	megakaryocytic-CD34+_Megakaryoblast\|World / Lineage and Cell class	ITGA2 ASAP2 MLC1 MED12L LHFPL6	2.06e-04	190	126	5	1d19b2bd55789bf13e1386332f46c605973d6f8e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADRA1B TENM3 LHFPL6 WDR86 HSD17B2	2.06e-04	190	126	5	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADRA1B TENM3 LHFPL6 WDR86 HSD17B2	2.06e-04	190	126	5	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKD TENM3 LGI2 TLE2 ADAMTS17	2.06e-04	190	126	5	8c9c230a509afaeee50644153974a5642b01a2b8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA2 XKR6 ACOT11 ADAMTS17 MED12L	2.06e-04	190	126	5	e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADRA1B TENM3 LHFPL6 WDR86 HSD17B2	2.11e-04	191	126	5	a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell	PSB-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CEL WNT11 ADGRB3 LIMS2 TENM3	2.11e-04	191	126	5	8f4637e801554e2343b974fe7794f01dd2151418
ToppCell	COVID-19-Myeloid-DC1\|COVID-19 / Condition, Lineage and Cell class	TTYH2 BTLA WDFY4 PTK2 SLC46A3	2.11e-04	191	126	5	9e44357cdeca46d2b26124bb063c8422ef930083
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DNAH3 PRSS12 ODAD2 CFAP52 SPAG16	2.11e-04	191	126	5	e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DNAH3 PRSS12 ODAD2 CFAP52 SPAG16	2.11e-04	191	126	5	9d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell	COPD-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	TTYH2 BTLA WDFY4 PTK2 MED12L	2.11e-04	191	126	5	3480e6d27dd4291765bbbb2acdb6a2e4f02c8085
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANKRD42 DNAH3 ODAD2 CFAP52 SPAG16	2.11e-04	191	126	5	96483adb97c81208aa513782550acd8a08b63866
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NLRP12 RIPOR2 ADGRB3 TCIRG1 FBN2	2.11e-04	191	126	5	47a2afc4102199b4bc76bd01b2967c8016186462
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DNAH3 PRSS12 ODAD2 CFAP52 SPAG16	2.11e-04	191	126	5	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADRA1B TENM3 LHFPL6 WDR86 HSD17B2	2.16e-04	192	126	5	9093a9e94a25682d109a7f6edc256a25a61103a0
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACLY TTYH2 TENM3 TULP4 ACOT11	2.16e-04	192	126	5	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RIPOR2 DGKD ADRA1B LGI2 FBN3	2.16e-04	192	126	5	3abee376c37c3646da33ac381aa63d50a01607a6
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTYH1 TTYH3 TENM3 MLC1 ACOT11	2.16e-04	192	126	5	261211a86e6f63b09c2ddce1d2d9257d311f1770
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD4+_T_cell_(ISG_high)\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	JADE2 BTLA TTC3 SOCS2 SYNJ2	2.16e-04	192	126	5	35557254738844c27ffcd00f3287fbcc0a4d0f3b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADRA1B TENM3 LHFPL6 WDR86 HSD17B2	2.16e-04	192	126	5	9ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCell	IPF-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	DNAH3 PRSS12 ODAD2 CFAP52 SPAG16	2.16e-04	192	126	5	d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 EHD4 LIMS2 SYNJ2 LHFPL6	2.16e-04	192	126	5	28eb3a5728e8901bcb5ba12f6b009f41b065fa37
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 LIMS2 WNT5B SYNJ2 LHFPL6	2.21e-04	193	126	5	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 EHD4 LIMS2 WNT5B SYNJ2	2.21e-04	193	126	5	6a623acd1adad9a78eddc32ffedb16352ad3fdfa
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKD TENM3 LGI2 TLE2 ADAMTS17	2.21e-04	193	126	5	5581a5ebcd21a2a8062ccfb917f088ec67a10a9c
Drug	3H-DHA	ITGA2 CHRM1 ADRA1D ADRA1B ADRB1	1.12e-07	22	125	5	CID000129515
Drug	Br-pindolol	ADRA1D ADRA1B ADRB1	3.19e-06	6	125	3	CID000125847
Drug	Epinephrine	ADRA1D ADRA1B ADRB1	8.87e-06	8	125	3	DB00668
Drug	alfuzosin	ADRA1D ADRA1B ADRB1 MARCO	1.00e-05	25	125	4	CID000002092
Drug	dibenamine	CHRM1 ADRA1D ADRA1B ADRB1	1.18e-05	26	125	4	CID000005820
Drug	dapiprazole	ADRA1D ADRA1B ADRB1	1.32e-05	9	125	3	CID003033538
Drug	bretylium	CHRM1 ADRA1D ADRA1B ADRB1	1.60e-05	28	125	4	CID000002431
Drug	WB4101	CHRM1 ADRA1D ADRA1B ADRB1	1.85e-05	29	125	4	CID000005685
Drug	Norepinephrine	ADRA1D ADRA1B ADRB1	1.88e-05	10	125	3	DB00368
Drug	L-659,066	ADRA1D ADRA1B ADRB1	1.88e-05	10	125	3	CID000163952
Drug	Droxidopa	ADRA1D ADRA1B ADRB1	1.88e-05	10	125	3	DB06262
Drug	DO 710	ADRA1D ADRA1B ADRB1	1.88e-05	10	125	3	CID003084985
Drug	dihydroalprenolol	CHRM1 ADRA1D ADRA1B ADRB1	2.12e-05	30	125	4	CID000043216
Drug	metoprolol	EED CHRM1 TNFRSF11B ADRA1D ADRA1B ADRB1	2.51e-05	105	125	6	CID000004171
Drug	benextramine	CHRM1 ADRA1D ADRA1B ADRB1	2.76e-05	32	125	4	CID000002317
Drug	Doxazosin	PTK2 ADRA1D ADRA1B ADRB1	2.76e-05	32	125	4	ctd:D017292
Drug	terazosin	ADRA1D ADRA1B ADRB1 MARCO	3.13e-05	33	125	4	CID000005401
Drug	SZL-49	ADRA1D ADRA1B ADRB1	3.43e-05	12	125	3	CID000004892
Drug	indoramin	ADRA1D ADRA1B ADRB1	4.44e-05	13	125	3	CID000033625
Drug	deriglidole	ADRA1D ADRA1B ADRB1	5.63e-05	14	125	3	CID000065945
Drug	propiomazine	CHRM1 ADRA1D ADRA1B	5.63e-05	14	125	3	CID000004940
Drug	Promazine	CHRM1 ADRA1D ADRA1B	5.63e-05	14	125	3	DB00420
Drug	MK-912	ADRA1D ADRA1B ADRB1	5.63e-05	14	125	3	CID000123679
Drug	Propiomazine	CHRM1 ADRA1D ADRA1B	5.63e-05	14	125	3	DB00777
Drug	Nicardipine	CHRM1 ADRA1D ADRA1B	5.63e-05	14	125	3	DB00622
Drug	3-hydroxy-4-methoxycinnamic acid	ADRA1D ADRA1B ADRB1	5.63e-05	14	125	3	CID000092126
Drug	NSC95090	CHRM1 ADRA1D ADRA1B ADRB1	6.79e-05	40	125	4	CID000003251
Drug	SKF 104078	ADRA1D ADRA1B ADRB1	7.00e-05	15	125	3	CID000122295
Drug	amosulalol	ADRA1D ADRA1B ADRB1	7.00e-05	15	125	3	CID000002169
Drug	HV723	ADRA1D ADRA1B ADRB1	7.00e-05	15	125	3	CID003081094
Drug	fluparoxan	ADRA1D ADRA1B ADRB1	8.59e-05	16	125	3	CID000072036
Drug	1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol	ADRA1D ADRA1B	8.94e-05	3	125	2	ctd:C099060
Drug	Alfuzosin	ADRA1D ADRA1B	8.94e-05	3	125	2	DB00346
Drug	Phenylephrine	ADRA1D ADRA1B	8.94e-05	3	125	2	DB00388
Drug	Dapiprazole	ADRA1D ADRA1B	8.94e-05	3	125	2	DB00298
Drug	2-(beta-(3-iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone	ADRA1D ADRA1B	8.94e-05	3	125	2	ctd:C048008
Drug	Tamsulosin	ADRA1D ADRA1B	8.94e-05	3	125	2	DB00706
Drug	abanoquil	ADRA1D ADRA1B	8.94e-05	3	125	2	ctd:C058534
Drug	ifoxetine	ADRA1D ADRA1B	8.94e-05	3	125	2	CID000071971
Drug	chlorethylclonidine	ADRA1D ADRA1B	8.94e-05	3	125	2	ctd:C051731
Drug	Wy 25309	ADRA1D ADRA1B	8.94e-05	3	125	2	CID000133818
Drug	XB513	ADRA1D ADRA1B	8.94e-05	3	125	2	CID000183813
Drug	NSC604985	CEL CHRM1	8.94e-05	3	125	2	CID000216244
Drug	naftopidil	ADRA1D ADRA1B ADRB1	1.04e-04	17	125	3	CID000004418
Drug	imiloxan	ADRA1D ADRA1B ADRB1	1.04e-04	17	125	3	CID000133621
Drug	Thiamine hydrochloride [67-03-8]; Up 200; 11.8uM; HL60; HG-U133A	DNAH3 CEL RTEL1 JADE2 CIAO1 TLE2 LHFPL6	1.07e-04	196	125	7	1744_UP
Drug	Cloxacillin sodium salt [642-78-4]; Down 200; 8.8uM; PC3; HT_HG-U133A	DNAH3 TNFRSF11B WNT5B ADRA1D SYNJ2 ACOT11 FUT4	1.10e-04	197	125	7	2126_DN
Drug	(S)-(-)-Atenolol [93379-54-5]; Up 200; 15uM; MCF7; HT_HG-U133A	RTEL1 WNT5B ADRA1D ACOT11 CDK13 SIGLEC6 EDDM3B	1.17e-04	199	125	7	6444_UP
Drug	thymoxamine	ADRA1D ADRA1B ADRB1	1.24e-04	18	125	3	CID000004260
Drug	Methotrimeprazine	CHRM1 ADRA1D ADRA1B	1.47e-04	19	125	3	DB01403
Drug	benalfocin	ADRA1D ADRA1B ADRB1	1.47e-04	19	125	3	CID000123981
Drug	RS-17053	ADRA1D ADRA1B ADRB1	1.47e-04	19	125	3	CID003894573
Drug	GI-3	CHRM1 ADRA1D ADRA1B ADRB1 MLC1 EDDM3B	1.63e-04	147	125	6	CID011957433
Drug	Doxepin	CHRM1 ADRA1D ADRA1B	1.72e-04	20	125	3	DB01142
Drug	midaglizole	ADRA1D ADRA1B ADRB1	1.72e-04	20	125	3	CID000068864
Drug	naphazoline	ADRA1D ADRA1B ADRB1	1.72e-04	20	125	3	CID000004436
Drug	CGP 20712A	CHRM1 ADRA1D ADRA1B ADRB1	1.77e-04	51	125	4	CID000002685
Drug	Labetalol	ADRA1B ADRB1	1.78e-04	4	125	2	DB00598
Drug	tamsulosin	ADRA1D ADRA1B	1.78e-04	4	125	2	ctd:C088482
Drug	sertindole	ADRA1D ADRA1B	1.78e-04	4	125	2	ctd:C066304
Drug	BE 2254	ADRA1D ADRA1B	1.78e-04	4	125	2	ctd:C010652
Drug	5-methylurapidil	ADRA1D ADRA1B	1.78e-04	4	125	2	ctd:C057446
Drug	B-HT 933	ADRA1D ADRA1B ADRB1	2.00e-04	21	125	3	CID000002277
Drug	ST-91	ADRA1B ADRB1 LHFPL6	2.00e-04	21	125	3	CID000020863
Drug	ARC 239	ADRA1D ADRA1B ADRB1	2.00e-04	21	125	3	CID000609483
Drug	6-fluoronorepinephrine	ADRA1D ADRA1B ADRB1	2.00e-04	21	125	3	CID000001862
Drug	tetraphenylporphyrin	NLRP12 ITGA2 SOCS2	2.00e-04	21	125	3	CID000070186
Drug	ICRF-193	NLRP2 PTK2 CDK13 ESPL1	2.21e-04	54	125	4	CID000115150
Drug	benoxathian	ADRA1D ADRA1B ADRB1	2.31e-04	22	125	3	CID000002325
Drug	labetalol	ADRA1D ADRA1B ADRB1	2.31e-04	22	125	3	CID000003869
Drug	silodosin	ADRA1D ADRA1B ADRB1	2.31e-04	22	125	3	CID005312125
Drug	Rfamide	FBN2 ABCE1 MRGPRX1 MRGPRX3	2.55e-04	56	125	4	CID000122185
Drug	fenoterol	EED ADRA1D ADRA1B ADRB1	2.55e-04	56	125	4	CID000003343
Drug	tizanidine	ADRA1D ADRA1B ADRB1	2.64e-04	23	125	3	CID000005487
Drug	cyanopindolol	ADRA1D ADRA1B ADRB1 ROS1	2.73e-04	57	125	4	CID000155346
Drug	AC1L9392	SLC7A13 FBN2	2.96e-04	5	125	2	CID000412320
Drug	Leniquinsin	ADRA1D ADRA1B	2.96e-04	5	125	2	CID000025195
Drug	AC1L9NP0	ADRA1D ADRA1B	2.96e-04	5	125	2	CID000449842
Drug	S-10089	ADRA1D ADRA1B	2.96e-04	5	125	2	CID000146399
Drug	CS-263	ADRA1D ADRA1B	2.96e-04	5	125	2	CID000137303
Drug	S 9871	ADRA1B ADRB1	2.96e-04	5	125	2	CID003036124
Drug	1,3-oxathiolane	CHRM1 SOCS2	2.96e-04	5	125	2	CID000065092
Drug	DJ-7141	ADRA1B ADRB1	2.96e-04	5	125	2	CID000174123
Drug	2,6-DMC	ADRA1B ADRB1	2.96e-04	5	125	2	CID000078576
Drug	5-methylgramine	ADRA1D ADRA1B	2.96e-04	5	125	2	CID000034855
Drug	then aldehyde	ITGA2 SOCS2	2.96e-04	5	125	2	CID000007364
Drug	MPV-2426	ADRA1B ADRB1	2.96e-04	5	125	2	CID006433097
Drug	metazosin	ADRA1D ADRA1B	2.96e-04	5	125	2	CID000093514
Drug	telluronium	ITGA2 SOCS2	2.96e-04	5	125	2	CID000021765
Drug	NA--can	ADRA1B ADRB1	2.96e-04	5	125	2	CID000007387
Drug	AC1O6ABX	ADRA1D ADRA1B	2.96e-04	5	125	2	CID006449894
Drug	KABI 2023	ADRA1D ADRA1B	2.96e-04	5	125	2	CID000192124
Drug	A-53693	ADRA1D ADRA1B	2.96e-04	5	125	2	CID003082713
Drug	lidamidine	ADRA1B ADRB1	2.96e-04	5	125	2	CID000047509
Drug	epinine	ADRA1D ADRA1B ADRB1	3.01e-04	24	125	3	CID000004382
Drug	ibopamine	ADRA1D ADRA1B ADRB1	3.01e-04	24	125	3	CID000068555
Drug	nipradilol	ADRA1D ADRA1B ADRB1	3.01e-04	24	125	3	CID000072006
Disease	connective tissue disease (implicated_via_orthology)	FBN2 FBN3	4.83e-05	3	119	2	DOID:65 (implicated_via_orthology)
Disease	Weill-Marchesani syndrome (implicated_via_orthology)	ADAMTS10 ADAMTS17	4.83e-05	3	119	2	DOID:0050475 (implicated_via_orthology)
Disease	Weill-Marchesani syndrome	ADAMTS10 ADAMTS17	9.63e-05	4	119	2	cv:C0265313
Disease	Weill-Marchesani syndrome (is_implicated_in)	ADAMTS10 ADAMTS17	9.63e-05	4	119	2	DOID:0050475 (is_implicated_in)
Disease	interferon-induced protein with tetratricopeptide repeats 3 measurement	NLRP12 CEL	4.44e-04	8	119	2	EFO_0801710
Disease	Malignant neoplasm of salivary gland	WNT5B MLC1 ESPL1	8.02e-04	45	119	3	C0220636
Disease	aortic valve stenosis (is_marker_for)	TNFRSF11B ADRB1	8.66e-04	11	119	2	DOID:1712 (is_marker_for)
Disease	Situs Inversus	PKD1L1 CFAP52	8.66e-04	11	119	2	C0037221
Disease	Salivary Gland Neoplasms	WNT5B MLC1 ESPL1	9.11e-04	47	119	3	C0036095
Disease	bone density	MC4R DGKD TNFRSF11B WNT5B FBN2 ESPL1 MARCO	1.02e-03	388	119	7	EFO_0003923
Disease	visceral heterotaxy (is_implicated_in)	PKD1L1 CFAP52	1.04e-03	12	119	2	DOID:0050545 (is_implicated_in)
Disease	Familial thoracic aortic aneurysm and aortic dissection	ADAMTS10 FBN2 MED12	1.29e-03	53	119	3	C4707243
Disease	colorectal health	PKD1L1 ADRA1D ADAMTS17 LHFPL6 ESPL1	1.36e-03	201	119	5	EFO_0008460
Disease	body fat distribution	DIP2B MC4R XKR6 ADAMTS10 ADAMTS17	1.39e-03	202	119	5	EFO_0004341
Disease	Tinnitus, response to cisplatin	ADRA1D TENM3	1.64e-03	15	119	2	GO_0072718, HP_0000360
Disease	amygdala volume change measurement	PKD1L1 FGGY	1.87e-03	16	119	2	EFO_0021490
Disease	anorectal malformation	RTEL1 CSMD2	2.64e-03	19	119	2	MONDO_0019938
Disease	polycystic ovary syndrome (biomarker_via_orthology)	ADRA1D ADRA1B	3.22e-03	21	119	2	DOID:11612 (biomarker_via_orthology)
Disease	chronic widespread pain	DIP2B ASAP2	3.86e-03	23	119	2	EFO_0010099

Protein segments in the cluster

Peptide	Gene	Start	Entry
TWSCIVALLAGCTGI	TTYH1	91	Q9H313
VVLSGVLLLCKRCWD	CBARP	61	Q8N350
CELWTSVDVLCVTAS	ADRB1	131	P08588
CILCTLLVQSKEVSW	EDDM3B	16	P56851
LNCIWTIEAEAGCTI	CSMD2	1296	Q7Z408
WCKLNGTTCVKLEDR	BTLA	71	Q7Z6A9
LCTWLESCLKSENGR	ADGRB3	171	O60242
PWDIVLCTSGTLISC	GPR12	46	P47775
LTKCCWVRVSLTELV	ACOT11	541	Q8WXI4
LIAAGSCDKVVRVWC	BRWD3	236	Q6RI45
WAAVDVLCCTASILS	ADRA1B	121	P35368
VACGTVEQMTWLCSL	CCDC144NL	151	Q6NUI1
AACVFSLGVTLWVIC	AADACL3	11	Q5VUY0
KLFVTACWLGLEDCL	LVRN	786	Q6Q4G3
LVVLGLTCCWAVASA	CEL	6	P19835
LTCCWAVASAAKLGA	CEL	11	P19835
TKALCCATVGRAWGL	FBN3	206	Q75N90
DVWSCGCILGELFTK	CDK13	896	Q14004
CWKDVTVGDFIRLSC	ATP10D	171	Q9P241
CSELWCLSKSNRCIT	ADAMTS10	496	Q9H324
AGLWCLVEGDTSCKT	ADAMTS17	496	Q8TE56
CLQLLVKWGCSIEDV	ANKRD42	146	Q8N9B4
GKTLQCISLIWTLQC	RAD54B	331	Q9Y620
AWGVSCSLELTCSAL	OR5D18	151	Q8NGL1
WGKCIRITLCASAVF	ANO6	446	Q4KMQ2
QLWILACAGITFICS	OR8U8	196	P0C7N1
CGATLLSSCWVLTAA	PRSS12	661	P56730
GDVVSALNKAWCVSC	LIMS2	266	Q7Z4I7
VVTLLCEWAVSCKRS	MED12L	506	Q86YW9
CCTVLSSEWLGVLKA	MED12L	1041	Q86YW9
SSEWLGVLKALCCSS	MED12L	1046	Q86YW9
VVALGILSWTVICCC	KIAA0319L	941	Q8IZA0
CLGLRWTCVSTENLV	KCNK15	146	Q9H427
WTVCVLAAAGLTCTA	FUT4	151	P22083
WLSTNLGILTCIECS	ASAP2	446	O43150
CVTASTDGTCIIWDL	CFAP52	476	Q8N1V2
RWALSCSLCKECTGT	JADE2	306	Q9NQC1
TACDLCSVTKLWPVT	PDE10A	661	Q9Y233
WGTTQAKCSCLTALD	DIP2B	346	Q9P265
EWLGVLKALCCSSNN	MED12	1091	Q93074
CVRWLGDLILSKSCE	EED	311	O75530
NSVLGKIWKLADCDC	EHD4	481	Q9H223
SAPAVCWIVCTTLKL	NLRP2	396	Q9NX02
CLLHWGTCILVSVDS	MSLNL	656	Q96KJ4
IAWLVFLCVVLCGSS	MRGPRX3	181	Q96LB0
SACKSSDLWALGCII	PDPK2P	231	Q6A1A2
CVCLVATSWGTSLVL	OR13H1	141	Q8NG92
TCTGVIWALLSFLCA	LHFPL6	6	Q9Y693
RTASCSNVTCWLKDV	ITGA2	1051	P17301
CTVLAVTSWACGSLL	OR2A5	141	Q96R48
CHCELTWSQLSGKVT	PARP14	351	Q460N5
KIAWISETLCIGCGI	ABCE1	46	P61221
IWALTKLGGLSCCTT	ESPL1	1271	Q14674
DIIAKACQVCSTWIG	HEATR5B	1361	Q9P2D3
NVSSACEGLCKWVRA	DNAH3	2876	Q8TD57
GVTARSLCSLVCKWT	FGGY	181	Q96C11
EWINTCSCLLSNIKG	AXDND1	801	Q5T1B0
VWEAFKVSLSSLCSC	CPNE7	281	Q9UBL6
KLARWTCCALLAGSE	EIF3D	431	O15371
VCWITVFLLQCSKGT	IGFL3	11	Q6UXB1
LVSTFCKDCVPETLW	CHRM1	386	P11229
VQCRGTESTLWSCTK	MARCO	486	Q9UEW3
VGIIISCIWAACTVS	MC4R	166	P32245
VCDKTCGSVLRLQDW	DGKD	251	Q16760
KFSCLWILGLCLVAT	GLIPR1L1	6	Q6UWM5
ASCIITAKLCTWAIC	CYP20A1	276	Q6UW02
TGLICIDSLKGTCWL	FBN2	886	P35556
SDTAWICLAVPTVLC	HSD17B2	6	P37059
TCILKWAETLASCPI	SCAF11	66	Q99590
TTWLLCTCMDTGEAL	SACS	1816	Q9NZJ4
AVWAICGTASLACSL	PKD1L1	2136	Q8TDX9
KVFCSGLATAVWLLC	OR13A1	156	Q8NGR1
KEFTSEICCGSLWGV	NRK	1206	Q7Z2Y5
TGKTLCLLCTTLAWR	RTEL1	46	Q9NZ71
VSLSVTVVLCGLCHW	SYT7	26	O43581
AKWTIGVCEDSVCRK	TRIM27	381	P14373
SLSLADLCVWATLKG	EPRS1	116	P07814
SCCDWLLKIICGVVT	SYNJ2	176	O15056
WFASLVSGCTLLVKV	TDRD9	1036	Q8NDG6
SCTKESIICVGSSWV	LGI2	41	Q8N0V4
ELAICSRSGAVCLWS	TAF1C	351	Q15572
EVARCGALALWSCSK	ODAD2	606	Q5T2S8
ECFKCALGSSWIISV	PTK2	256	Q05397
SWSCSCIQCELKIGS	GPRASP2	581	Q96D09
GKVCSLAVCAVAWLV	MED24	611	O75448
EWLCSVVALQCSILK	PHF12	431	Q96QT6
ISLCVVKCTSWNEGS	SLC46A3	431	Q7Z3Q1
CGAVLIDSCWLVSTT	PRSS47P	106	A8MTI9
LCRLTINKCTGAIWG	SOCS2	166	O14508
AVKTGSICWAAKCAL	STT3A	186	P46977
VWGASITTLVFLCVC	SIGLEC6	351	O43699
SAPAVCWIVCTTLKL	NLRP7	361	Q8WX94
LSWVDICFSTCIVPK	OR7D2	66	Q96RA2
VAWLIFLCVVLCGSS	MRGPRX1	181	Q96LB2
WKALGTTLACCQDSD	MROH2B	616	Q7Z745
KLCTLLVLCAWLSGF	OR6C3	136	Q9NZP0
LSLLSFWTKCCSPVG	RIPOR2	811	Q9Y4F9
LTKPIVCWCIGTCAT	ACLY	736	P53396
VWAAVDVLCCTASIL	ADRA1D	171	P25100
WKCICTLSGFHSRTI	CIAO1	241	O76071
LCSDSNILCLSWKGR	TULP4	11	Q9NRJ4
CEECGKAFIWSSVLT	ZNF93	371	P35789
KILASSCCAELLWGI	XKR6	506	Q5GH73
CCALVFLDISIKWTT	TNFRSF11B	6	O00300
CRIWDAASGQCLKTL	WDR5B	191	Q86VZ2
LVLTSDIWLCLKCGF	USP45	76	Q70EL2
TVCLGGCLKLWDTVR	TEP1	1776	Q99973
TGCAWTKDNLLISCS	TEP1	2111	Q99973
DIWSLGCIILDMTSC	STKLD1	216	Q8NE28
SCCITWTAVVAGLIC	TTYH2	86	Q9BSA4
TTVKLWDLCKGDCIL	SPAG16	416	Q8N0X2
TTESVWACLKCSHVA	USP49	31	Q70CQ1
LLVSGSQDCTCILWD	WDFY4	2996	Q6ZS81
ICSIWCSKPISVLQD	TTC3	66	P53804
GVSGSCSLKTCWLQL	WNT5B	221	Q9H1J7
GLCPDLECVWVTKSL	ZNF470	91	Q6ECI4
SWKCTALCAVGVSVL	TENM3	306	Q9P273
WISVVQCTVLNSCLK	ROS1	21	P08922
CVWAGCAILAMTSTL	SLC7A13	51	Q8TCU3
LKAGSSWQCDTCLLQ	NUP153	656	P49790
KWAVLCVTGLAKDCL	ZBED6	521	P86452
GSCSIRTCWKGLQEL	WNT11	216	O96014
ADVSCLWKLAGDACT	TTC37	711	Q6PGP7
LVIIGWCSLSASKIF	YIPF7	236	Q8N8F6
VRVQCLWCLSDGKTV	WDR26	486	Q9H7D7
TAWCVIIATLVCSAG	TTYH3	86	Q9C0H2
ESCVLSLKFASCGRW	TLE2	671	Q04725
TVKCWLADTGECVRT	WDR86	256	Q86TI4
VSTTHKCLIAEAWCS	TCIRG1	311	Q13488
VTTTCLIWFGCKLVL	MLC1	121	Q15049
WLDSCGLTAKACENL	NLRP12	976	P59046
AVLVTWDTCIGSEIC	NADSYN1	161	Q6IA69