Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transcription coregulator activity	CNOT6 SUPT20HL1 KDM5B SUPT20HL2 ELK1 KMT2D MED1 DTX1	1.30e-05	562	40	8	GO:0003712
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	CNOT6 SUPT20HL1 KDM5B SUPT20HL2 ELK1 ERCC2 KMT2D MED1 TCOF1 DTX1	7.20e-05	1160	40	10	GO:0030674
GeneOntologyMolecularFunction	nuclear receptor coactivator activity	CNOT6 ELK1 MED1	2.47e-04	61	40	3	GO:0030374
GeneOntologyMolecularFunction	molecular adaptor activity	CNOT6 SUPT20HL1 KDM5B SUPT20HL2 ELK1 ERCC2 KMT2D MED1 TCOF1 DTX1	2.61e-04	1356	40	10	GO:0060090
GeneOntologyMolecularFunction	transcription coactivator activity	CNOT6 ELK1 KMT2D MED1 DTX1	3.31e-04	303	40	5	GO:0003713
GeneOntologyMolecularFunction	Notch binding	DLL4 DTX1	1.33e-03	27	40	2	GO:0005112
GeneOntologyMolecularFunction	histone acetyltransferase binding	MED1 ECD	1.54e-03	29	40	2	GO:0035035
GeneOntologyBiologicalProcess	nucleolar large rRNA transcription by RNA polymerase I	ERCC2 TCOF1 MTOR	1.58e-05	26	39	3	GO:0042790
GeneOntologyCellularComponent	dendrite	DPYSL5 DIP2B ELK1 MTOR PREX1 SIPA1L1 SH3GL2 KHSRP KIF1C	2.75e-05	858	40	9	GO:0030425
GeneOntologyCellularComponent	dendritic tree	DPYSL5 DIP2B ELK1 MTOR PREX1 SIPA1L1 SH3GL2 KHSRP KIF1C	2.80e-05	860	40	9	GO:0097447
GeneOntologyCellularComponent	cell body	DPYSL5 DIP2B ELK1 C4BPA MTOR SIPA1L1 SH3GL2 KHSRP	3.20e-04	929	40	8	GO:0044297
GeneOntologyCellularComponent	CCR4-NOT complex	CNOT6 TNKS1BP1	4.21e-04	16	40	2	GO:0030014
GeneOntologyCellularComponent	somatodendritic compartment	DPYSL5 DIP2B ELK1 MTOR PREX1 SIPA1L1 SH3GL2 KHSRP KIF1C	4.22e-04	1228	40	9	GO:0036477
GeneOntologyCellularComponent	neuronal cell body	DPYSL5 DIP2B ELK1 MTOR SIPA1L1 SH3GL2 KHSRP	9.32e-04	835	40	7	GO:0043025
GeneOntologyCellularComponent	SAGA complex	SUPT20HL1 SUPT20HL2	1.04e-03	25	40	2	GO:0000124
GeneOntologyCellularComponent	intracellular protein-containing complex	CNOT6 SUPT20HL1 TNKS1BP1 SUPT20HL2 ERCC2 MED1 MTOR	2.23e-03	972	40	7	GO:0140535
GeneOntologyCellularComponent	SAGA-type complex	SUPT20HL1 SUPT20HL2	2.53e-03	39	40	2	GO:0070461
Domain	FHA	MKI67 KIF1C	1.55e-03	28	39	2	SM00240
Domain	FHA_DOMAIN	MKI67 KIF1C	1.90e-03	31	39	2	PS50006
Domain	FHA	MKI67 KIF1C	1.90e-03	31	39	2	PF00498
Domain	-	RNF130 KDM5B KMT2D SH3RF3 DTX1	2.31e-03	449	39	5	3.30.40.10
Domain	Znf_RING/FYVE/PHD	RNF130 KDM5B KMT2D SH3RF3 DTX1	2.54e-03	459	39	5	IPR013083
Domain	FHA_dom	MKI67 KIF1C	2.56e-03	36	39	2	IPR000253
Domain	-	MKI67 KIF1C	2.56e-03	36	39	2	2.60.200.20
Domain	ZF_RING_1	RNF130 KMT2D SH3RF3 DTX1	3.09e-03	291	39	4	PS00518
Domain	ZF_RING_2	RNF130 KMT2D SH3RF3 DTX1	3.37e-03	298	39	4	PS50089
Domain	PDZ	PREX1 AHNAK SIPA1L1	3.62e-03	148	39	3	SM00228
Domain	RING	RNF130 KMT2D SH3RF3 DTX1	3.66e-03	305	39	4	SM00184
Domain	-	PREX1 AHNAK SIPA1L1	3.75e-03	150	39	3	2.30.42.10
Domain	PDZ	PREX1 AHNAK SIPA1L1	3.83e-03	151	39	3	PS50106
Domain	PDZ	PREX1 AHNAK SIPA1L1	3.90e-03	152	39	3	IPR001478
Domain	Znf_RING	RNF130 KMT2D SH3RF3 DTX1	4.63e-03	326	39	4	IPR001841
Domain	SMAD_FHA_domain	MKI67 KIF1C	5.27e-03	52	39	2	IPR008984
Domain	HEAT	MTOR HEATR4	6.52e-03	58	39	2	IPR000357
Domain	HMG_box_dom	KMT2D SH3GL2	8.13e-03	65	39	2	IPR009071
Domain	HEAT_REPEAT	MTOR HEATR4	9.38e-03	70	39	2	PS50077
Domain	PHD	KDM5B KMT2D	1.07e-02	75	39	2	PF00628
Domain	-	MTOR HEATR4 RRP12	1.11e-02	222	39	3	1.25.10.10
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EPHB4 TNKS1BP1 ERCC2 KMT2D ATP2A3 MTOR PREX1 PPP1R3B AHNAK RRP12 SBF2	3.15e-08	1105	40	11	35748872
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DPYSL5 DIP2B KDM5B TNKS1BP1 MTOR SH3RF3 AHNAK SIPA1L1 KIF1C	4.60e-07	861	40	9	36931259
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	MKI67 TNKS1BP1 ACADVL ATP2A3 AHNAK KHSRP	1.13e-06	298	40	6	30737378
Pubmed	Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin.	GRHL3 MTOR	1.29e-06	2	40	2	29238073
Pubmed	Increased expression of ERCC2 gene in head and neck cancer is associated with aggressive tumors: a systematic review and case-control study.	MKI67 ERCC2	1.29e-06	2	40	2	26659720
Pubmed	Vascular endothelial growth factor-A inhibits EphB4 and stimulates delta-like ligand 4 expression in adult endothelial cells.	EPHB4 DLL4	1.29e-06	2	40	2	23394931
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	MKI67 TNKS1BP1 MED1 TCOF1 RRP12 KHSRP KIF1C	1.57e-06	503	40	7	16964243
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MKI67 DIP2B TNKS1BP1 KMT2D MED1 TCOF1 SIPA1L1 RRP12	2.38e-06	774	40	8	15302935
Pubmed	Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung.	MKI67 EPHB4 DLL4	2.46e-06	23	40	3	33830085
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	MKI67 TNKS1BP1 KMT2D MED1 TCOF1 KHSRP	2.46e-06	341	40	6	32971831
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DPYSL5 DIP2B KDM5B TNKS1BP1 MED1 TCOF1 ZNF532 RRP12 KHSRP	3.03e-06	1082	40	9	38697112
Pubmed	KMT2D deficiency disturbs the proliferation and cell cycle activity of dental epithelial cell line (LS8) partially via Wnt signaling.	MKI67 KMT2D	3.87e-06	3	40	2	34724040
Pubmed	Suppression of EphB4 improves the inhibitory effect of mTOR shRNA on the biological behaviors of ovarian cancer cells by down-regulating Akt phosphorylation.	EPHB4 MTOR	3.87e-06	3	40	2	22684558
Pubmed	GRHL3/GET1 and trithorax group members collaborate to activate the epidermal progenitor differentiation program.	KMT2D GRHL3	3.87e-06	3	40	2	22829784
Pubmed	Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis.	EPHB4 DLL4	3.87e-06	3	40	2	21092311
Pubmed	The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.	SUPT20HL1 SUPT20HL2	3.87e-06	3	40	2	24220028
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	MKI67 TNKS1BP1 MED1 TCOF1 AHNAK KHSRP	6.06e-06	399	40	6	35987950
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	MKI67 TNKS1BP1 TCOF1 ACADVL AHNAK SIPA1L1 KHSRP	6.59e-06	626	40	7	33644029
Pubmed	DAP1, a novel substrate of mTOR, negatively regulates autophagy.	DAP MTOR	7.73e-06	4	40	2	20537536
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MKI67 TNKS1BP1 TCOF1 MTOR AHNAK RRP12 KHSRP	8.67e-06	653	40	7	22586326
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	MKI67 TNKS1BP1 MED1 TCOF1 AHNAK RRP12 ECD KHSRP	9.42e-06	934	40	8	33916271
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	MED1 TCOF1 RRP12 ECD KHSRP	1.17e-05	259	40	5	30404004
Pubmed	Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.	MTOR PREX1	1.29e-05	5	40	2	21339740
Pubmed	mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.	MKI67 MTOR	1.29e-05	5	40	2	33303641
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	MKI67 MED1 TCOF1 AHNAK KHSRP	1.46e-05	271	40	5	32433965
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	DPYSL5 CNOT6 TNKS1BP1 MED1 MTOR SH3RF3 AHNAK SIPA1L1 KIF1C	1.51e-05	1321	40	9	27173435
Pubmed	Dosage-sensitive requirement for mouse Dll4 in artery development.	EPHB4 DLL4	1.93e-05	6	40	2	15466159
Pubmed	Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation.	MKI67 DLL4 PTGS1	2.21e-05	47	40	3	32747435
Pubmed	Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice.	MKI67 GRHL3	2.70e-05	7	40	2	27907249
Pubmed	Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis.	EPHB4 DLL4	2.70e-05	7	40	2	18952909
Pubmed	Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII.	EPHB4 DLL4	2.70e-05	7	40	2	28005008
Pubmed	P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration.	MTOR PREX1	2.70e-05	7	40	2	17565979
Pubmed	Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.	MKI67 MTOR	2.70e-05	7	40	2	17141160
Pubmed	A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.	DPYSL5 GRHL3 PPP1R3B	3.55e-05	55	40	3	22581228
Pubmed	Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification.	SUPT20HL1 SUPT20HL2	3.60e-05	8	40	2	21802298
Pubmed	Identifying key genes related to inflammasome in severe COVID-19 patients based on a joint model with random forest and artificial neural network.	MKI67 MTOR	3.60e-05	8	40	2	37113134
Pubmed	Dysregulation of Grainyhead-like 3 expression causes widespread developmental defects.	MKI67 GRHL3	3.60e-05	8	40	2	36606449
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TNKS1BP1 KMT2D MED1 TCOF1 AHNAK KHSRP	3.66e-05	549	40	6	38280479
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	MKI67 CNOT6 TNKS1BP1 NDUFAF7 AHNAK RRP12 ECD KIF1C	4.31e-05	1155	40	8	20360068
Pubmed	The small GTPase Rheb is required for spermatogenesis but not oogenesis.	MKI67 MTOR	4.62e-05	9	40	2	24713393
Pubmed	Ezh2-dependent methylation in oral epithelia promotes secondary palatogenesis.	MKI67 GRHL3	4.62e-05	9	40	2	37435868
Pubmed	BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development.	EPHB4 DLL4	4.62e-05	9	40	2	23406903
Pubmed	Grhl3 and Lmo4 play coordinate roles in epidermal migration.	MKI67 GRHL3	5.77e-05	10	40	2	18619436
Pubmed	mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.	CNOT6 MTOR	5.77e-05	10	40	2	27618784
Pubmed	Unique functions for Notch4 in murine embryonic lymphangiogenesis.	MKI67 DLL4	5.77e-05	10	40	2	34665379
Pubmed	PI3K-mediated PDGFRα signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways.	MKI67 TCOF1	5.77e-05	10	40	2	24788519
Pubmed	Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain.	MKI67 MTOR	7.05e-05	11	40	2	23100423
Pubmed	Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.	SUPT20HL1 SUPT20HL2	7.05e-05	11	40	2	24051374
Pubmed	The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function.	MKI67 GRHL3	7.05e-05	11	40	2	31578523
Pubmed	Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma.	MKI67 GRHL3	7.05e-05	11	40	2	26063791
Pubmed	Mutations in EPHB4 cause human venous valve aplasia.	MKI67 EPHB4	7.05e-05	11	40	2	34403370
Pubmed	IRF6 expression in basal epithelium partially rescues Irf6 knockout mice.	MKI67 GRHL3	7.05e-05	11	40	2	28643456
Pubmed	Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth.	CNOT6 TNKS1BP1	8.45e-05	12	40	2	17452450
Pubmed	Origin of the brush cell lineage in the mouse intestinal epithelium.	MKI67 PTGS1	8.45e-05	12	40	2	22185794
Pubmed	Human Ccr4-Not complexes contain variable deadenylase subunits.	CNOT6 TNKS1BP1	8.45e-05	12	40	2	19558367
Pubmed	Venous identity requires BMP signalling through ALK3.	EPHB4 DLL4	8.45e-05	12	40	2	30692543
Pubmed	Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation.	CNOT6 TNKS1BP1	8.45e-05	12	40	2	31320642
Pubmed	Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.	DLL4 DTX1	8.45e-05	12	40	2	15465494
Pubmed	Hypoxia-inducible factor-1 stimulates postnatal lung development but does not prevent O2-induced alveolar injury.	MKI67 EPHB4	8.45e-05	12	40	2	25180700
Pubmed	Delta-like ligand-4 regulates Notch-mediated maturation of second heart field progenitor-derived pharyngeal arterial endothelial cells.	EPHB4 DLL4	8.45e-05	12	40	2	36082581
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MED1 MTOR AHNAK RRP12	8.57e-05	202	40	4	33005030
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	TNKS1BP1 ACADVL ATP2A3 MTOR AHNAK KHSRP	9.07e-05	647	40	6	26618866
Pubmed	Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling.	EPHB4 DLL4	9.98e-05	13	40	2	23178125
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KDM5B KMT2D	9.98e-05	13	40	2	21502505
Pubmed	cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.	ACADVL MTOR	9.98e-05	13	40	2	18337751
Pubmed	Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2.	EPHB4 DLL4	9.98e-05	13	40	2	37317851
Pubmed	The G4 resolvase RHAU regulates ventricular trabeculation and compaction through transcriptional and post-transcriptional mechanisms.	MKI67 DLL4	9.98e-05	13	40	2	34838591
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	MKI67 KMT2D TCOF1 SIPA1L1 KHSRP	1.04e-04	410	40	5	26949251
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KDM5B TNKS1BP1 KMT2D ZNF532 AHNAK	1.14e-04	418	40	5	34709266
Pubmed	Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription.	EPHB4 DLL4	1.34e-04	15	40	2	33454003
Pubmed	Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.	EPHB4 DLL4	1.34e-04	15	40	2	25072663
Pubmed	Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3 (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of Myocardium without Affecting Hippo Pathway.	MKI67 MTOR	1.34e-04	15	40	2	38474134
Pubmed	Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.	MKI67 DLL4	1.34e-04	15	40	2	31420575
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	MKI67 RNF130 KDM5B ZNF532 CRIP3 ZNF445	1.49e-04	709	40	6	22988430
Pubmed	IRF6 and AP2A Interaction Regulates Epidermal Development.	MKI67 GRHL3	1.53e-04	16	40	2	29913133
Pubmed	Arterialization requires the timely suppression of cell growth.	EPHB4 DLL4	1.53e-04	16	40	2	33299176
Pubmed	Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.	MKI67 MTOR	1.53e-04	16	40	2	36440598
Pubmed	Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects.	MKI67 SIPA1L1	1.53e-04	16	40	2	36092713
Pubmed	Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments.	MKI67 DLL4	1.53e-04	16	40	2	22464328
Pubmed	Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon.	MKI67 DLL4	1.53e-04	16	40	2	21561989
Pubmed	A perivascular niche for multipotent progenitors in the fetal testis.	MKI67 DLL4	1.73e-04	17	40	2	30375389
Pubmed	Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.	MKI67 MTOR	1.73e-04	17	40	2	17322895
Pubmed	The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation.	MKI67 C4BPA	1.73e-04	17	40	2	23401851
Pubmed	Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.	MKI67 DLL4	1.73e-04	17	40	2	23362346
Pubmed	mTOR regulates brain morphogenesis by mediating GSK3 signaling.	MKI67 MTOR	1.73e-04	17	40	2	25273085
Pubmed	Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos.	EPHB4 DLL4	1.73e-04	17	40	2	18559979
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	TNKS1BP1 TCOF1 ACADVL AHNAK RRP12 ECD KHSRP KIF1C	1.77e-04	1415	40	8	28515276
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	MKI67 TCOF1 AHNAK RRP12	1.80e-04	245	40	4	21182205
Pubmed	The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development.	EPHB4 DLL4	1.95e-04	18	40	2	16678147
Pubmed	Integrin-linked kinase is an adaptor with essential functions during mouse development.	MKI67 MTOR	1.95e-04	18	40	2	19829382
Pubmed	Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.	EPHB4 DLL4	1.95e-04	18	40	2	18093989
Pubmed	CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains.	MKI67 MTOR	1.95e-04	18	40	2	33462112
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	MKI67 TNKS1BP1 MTOR AHNAK SIPA1L1 RRP12 ECD KHSRP	1.99e-04	1440	40	8	30833792
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	TNKS1BP1 TCOF1 AHNAK ECD	2.13e-04	256	40	4	33397691
Pubmed	The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.	EPHB4 DLL4	2.18e-04	19	40	2	20627076
Pubmed	Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models.	MKI67 MTOR	2.18e-04	19	40	2	23744272
Pubmed	Coronary arteries form by developmental reprogramming of venous cells.	EPHB4 DLL4	2.18e-04	19	40	2	20336138
Pubmed	Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.	MKI67 MTOR	2.18e-04	19	40	2	27246713
Pubmed	Tsc1 deficiency-mediated mTOR hyperactivation in vascular endothelial cells causes angiogenesis defects and embryonic lethality.	MKI67 MTOR	2.18e-04	19	40	2	24129405
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	DPYSL5 MKI67 TCOF1	2.30e-04	103	40	3	32744500
Interaction	ESRRB interactions	KMT2D MED1 ATP2A3 AHNAK RRP12 KHSRP	1.04e-05	262	39	6	int:ESRRB
Cytoband	Xp22.11	SUPT20HL1 SUPT20HL2	1.54e-04	21	40	2	Xp22.11
Cytoband	12q13.12	DIP2B KMT2D	5.10e-04	38	40	2	12q13.12
Cytoband	5q35.3	CNOT6 RNF130	3.14e-03	95	40	2	5q35.3
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	ACADVL ATP2A3 KIF1C	3.41e-03	346	40	3	chr17p13
GeneFamily	PDZ domain containing	PREX1 AHNAK SIPA1L1	1.17e-03	152	25	3	1220
Coexpression	GSE40225_WT_VS_RIP_B7X_DIABETIC_MOUSE_PANCREATIC_CD8_TCELL_UP	RNF130 CRIP3 PTGS1 DTX1 SIPA1L1	1.27e-05	199	40	5	M9238
ToppCell	facs-Skin-Anagen-24m-Epithelial-epidermal_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM5B GRHL3 PTGS1 SIPA1L1 SH3GL2	3.93e-07	167	40	5	02c89069dcd0e87f7502e32b14e7cbd3cab81a09
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	CNOT6 DIP2B KDM5B MED1 SBF2	8.03e-07	193	40	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MKI67 ELK1 C4BPA DLL4	1.12e-05	155	40	4	4559e3011514041b65c17ae4ede29da202bce14c
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 DLL4 PTGS1 AHNAK	2.30e-05	186	40	4	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	facs-Bladder\|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAP GRHL3 PTGS1 SH3GL2	2.35e-05	187	40	4	dd5ca59417fd1b388fd975f0f3e1f3245d66ebc5
ToppCell	droplet-Bladder\|droplet / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAP GRHL3 PTGS1 SH3GL2	2.50e-05	190	40	4	170484f7a6f0a0d0792bbe1bb04abad060b7188e
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 DLL4 PTGS1 AHNAK	2.50e-05	190	40	4	b7fc451e160e31dc898b122de844b501f587db67
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 DLL4 PTGS1 AHNAK	2.50e-05	190	40	4	83cc851fb9f644b17a8ebf4d99a646003769a22f
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 DLL4 PTGS1 AHNAK	2.50e-05	190	40	4	5f440d4b334d66d419c03bd828f7d93f16c1ce67
ToppCell	droplet-Skin-nan-21m-Epithelial-epidermal_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM5B GRHL3 PTGS1 SIPA1L1	2.55e-05	191	40	4	c5ef34d138cd797029dfefaf4c52d16ba6a76c38
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	MKI67 RNF130 PREX1 SIPA1L1	2.60e-05	192	40	4	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	MKI67 RNF130 PREX1 SIPA1L1	2.66e-05	193	40	4	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	Differ-Basal\|World / shred by cell class for mouse tongue	DPYSL5 GRHL3 PTGS1 KHSRP	2.71e-05	194	40	4	851eff82c9f3d44c86e3e127a804bbd1fced6a7c
ToppCell	facs-Lung-nan-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 DLL4 ATP2A3 DTX1	2.77e-05	195	40	4	7f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell	COVID-19-Myeloid-Monocytes\|COVID-19 / group, cell type (main and fine annotations)	RNF130 PREX1 SIPA1L1 SBF2	2.82e-05	196	40	4	04d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCell	COVID-19-Myeloid-Transitioning_MDM\|COVID-19 / group, cell type (main and fine annotations)	RNF130 PREX1 SIPA1L1 SBF2	2.82e-05	196	40	4	4929cfed1f150c1fde4d79cb49895c2ea467a18f
ToppCell	Adult-Immune-mast_cell-D231\|Adult / Lineage, Cell type, age group and donor	TCOF1 ATP2A3 PTGS1	3.75e-04	157	40	3	4c63bb91f8708644e6ce2500072a4eeb8e1079dd
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D122\|Adult / Lineage, Cell type, age group and donor	EPHB4 SH3RF3 PTGS1	3.96e-04	160	40	3	0cfe130606af433b2aa90e0a20b6c44659dd6fd4
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATP2A3 PTGS1 KIF1C	4.03e-04	161	40	3	f5df8c6a340d5026726804b103e32137f363ca40
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PREX1 PPP1R3B KIF1C	4.11e-04	162	40	3	5731f9514434296132df4bc86f78ce87b07cdeca
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	MTOR AHNAK KIF1C	4.11e-04	162	40	3	810881210e015c788814e4fe8d7a24c929cf2621
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PREX1 PPP1R3B KIF1C	4.11e-04	162	40	3	0321fc954ae4ad67ca438cbbc84632562d222188
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-NK_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYSL5 PREX1 AHNAK	4.18e-04	163	40	3	2e1c1193c04620cc187b1567dfba025beef1e4e1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 SH3RF3 PREX1	4.18e-04	163	40	3	73c03e29a6d7a6863c5e9aa5e8b963ef691f1ddb
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DPYSL5 DLL4 ATP2A3	4.33e-04	165	40	3	a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCell	normal_Lung-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	TCOF1 PREX1 PTGS1	4.41e-04	166	40	3	07b498eb341abec02a3ccaae320bdbb5cd6883c5
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ELK1 DLL4 NDUFAF7	4.56e-04	168	40	3	8459d0a1bf6d4b5c83001097331f8b78fceb9305
ToppCell	Adult-Immune-enucleated_erythrocyte-D122\|Adult / Lineage, Cell type, age group and donor	ATP2A3 PTGS1 RRP12	4.64e-04	169	40	3	d5624e5b3687bd3f18f3a2b47a94d11eb1fbdb75
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	TNKS1BP1 ATP2A3 PTGS1	4.64e-04	169	40	3	ea600c63cf9572bc4b3cad6392f67bd0d92c7fc9
ToppCell	CTRL-Myeloid-Neutrophil\|Myeloid / Disease state, Lineage and Cell class	C4BPA PREX1 PPP1R3B	4.72e-04	170	40	3	151dabe1d240dde414c881bf4fa816c69fa1c32d
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP2A3 DTX1 AHNAK	4.81e-04	171	40	3	872b3b33cd3893d63c45617db0269692430b0e8b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ATP2A3 PTGS1 ZNF445	4.89e-04	172	40	3	3a37569a5902f3c65ff8d3912421309a8c82ee9b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ATP2A3 PTGS1 ZNF445	4.89e-04	172	40	3	cc9d9dae290f11f8c348c78228af4e49469dc93b
ToppCell	droplet-Marrow-nan-24m-Hematologic-erythroid_progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 DTX1 SBF2	4.89e-04	172	40	3	910ec7794ea4000db4ef1e2c34e08dbc0243df2c
ToppCell	CTRL-Myeloid-Neutrophil\|CTRL / Disease state, Lineage and Cell class	C4BPA PREX1 PPP1R3B	4.89e-04	172	40	3	ef3a6fe3b7300959f9f71130200c7fb8741c42b0
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	TCOF1 AHNAK SIPA1L1	4.97e-04	173	40	3	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNKS1BP1 MED1 MTOR	5.06e-04	174	40	3	feed99acd868db61f045e666dbfdcaed91ca1488
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP2A3 DTX1 AHNAK	5.14e-04	175	40	3	f12e230a7d0d265542c5698231a3eb0876ac4cc8
ToppCell	facs-Trachea-24m-Hematologic-lymphocytic-B_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ATP2A3 DTX1 SIPA1L1	5.23e-04	176	40	3	318dc722b95e269002fb01a0feb91c0c8539e150
ToppCell	facs-Trachea-24m-Hematologic-lymphocytic-B_cell-B_cell_of_the_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ATP2A3 DTX1 SIPA1L1	5.23e-04	176	40	3	f6891006d816309edabe75b2abf60675f2958e55
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLL4 SH3RF3 PREX1	5.23e-04	176	40	3	64e426f5e84884ce2c29acf6f4b958962a63927f
ToppCell	Adult-Endothelial-endothelial_cell_of_vein\|Adult / Lineage, Cell type, age group and donor	EPHB4 SH3RF3 PTGS1	5.23e-04	176	40	3	043683c61c5d1a7f8a4666a612310246bd3d83a2
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYSL5 MTOR ZNF445	5.31e-04	177	40	3	c6812679aa6522d03bd29144e71c5fae6a92325e
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYSL5 MTOR ZNF445	5.31e-04	177	40	3	ff97398d2adb83063b7c53a264bfae86ea7ea304
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DLL4 ATP2A3 PREX1	5.40e-04	178	40	3	c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_8\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TNKS1BP1 GRHL3 SIPA1L1	5.49e-04	179	40	3	0624dd537a68736f4d7b8b4de2c56168ed0e60a9
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_8\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TNKS1BP1 GRHL3 SIPA1L1	5.49e-04	179	40	3	163f5430d72ea0c1b239ea5d21e53be536636d3d
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DLL4 SH3RF3 PREX1	5.58e-04	180	40	3	d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell	Children_(3_yrs)-Immune-B_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CRIP3 ATP2A3 DTX1	5.58e-04	180	40	3	40a12eb852373ae3d7c8d9bca376b0ae99f724b3
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-nan\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP2A3 PPP1R3B AHNAK	5.58e-04	180	40	3	a0faed4cf23f6d5e6e8f6b0284cea8a5bd0680a0
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 PTGS1 DTX1	5.67e-04	181	40	3	cef034030e6b029a49ae56be37ea1fac1a5c350e
ToppCell	droplet-Liver-Npc-18m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP2A3 DTX1 AHNAK	5.67e-04	181	40	3	1a82b38494ca609238e918c56f7938320b9d467d
ToppCell	COPD-Myeloid-Mast\|World / Disease state, Lineage and Cell class	RNF130 ATP2A3 PTGS1	5.76e-04	182	40	3	68a1e7b804f309bfd6c23d65fad20a9a962712ae
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DLL4 ATP2A3 PREX1	5.95e-04	184	40	3	a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PREX1 AHNAK SIPA1L1	5.95e-04	184	40	3	d1ea2b60fb1ca1a0b809d131310c43903a9e84ce
ToppCell	droplet-Heart-4Chambers-21m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 DLL4 PTGS1	5.95e-04	184	40	3	f17d713af4a97dff4eeeab24c405677ef2ffcf84
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory-Tuft-Tuft\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KDM5B GRHL3 ATP2A3	6.04e-04	185	40	3	1fbdc96da0623c3935ae9d29dcb4ba9c474e5c21
ToppCell	droplet-Bladder-BLADDER-1m-Hematologic-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MKI67 ATP2A3 PREX1	6.04e-04	185	40	3	969248b63d4ce335f223528de756bcddffadbd77
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory-Tuft\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KDM5B GRHL3 ATP2A3	6.04e-04	185	40	3	b45487daac116e3d3d65ac2b0f81d1bf7d1a1914
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RNF130 ATP2A3 PTGS1	6.14e-04	186	40	3	de55471dd5c842026b409cfebf67fe32f079a011
ToppCell	COPD-Myeloid-Mast\|COPD / Disease state, Lineage and Cell class	RNF130 ATP2A3 PTGS1	6.14e-04	186	40	3	def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell\|TCGA-Uvea / Sample_Type by Project: Shred V9	DAP ACADVL DLL4	6.14e-04	186	40	3	e8580a2093eb7e50aad55ec7fada850d2fed8ae1
ToppCell	facs-Kidney-nan-24m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRHL3 RRP12 SH3GL2	6.14e-04	186	40	3	7380af16e537cc49a2bb24ac50663d13c38459a7
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB4 DLL4 ATP2A3	6.14e-04	186	40	3	b80aaeebc03a318052076d2f02c123f5ddc5e73a
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB4 DLL4 ATP2A3	6.14e-04	186	40	3	8a8ed1502542d4895cba3fd5d534256206578716
ToppCell	facs-Kidney-nan-24m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRHL3 RRP12 SH3GL2	6.14e-04	186	40	3	d56ccbe26bfddba0e2c54e7c7a5ca7f46fd3d891
ToppCell	Differ-KC\|World / shred by cell class for mouse tongue	GRHL3 PTGS1 KHSRP	6.23e-04	187	40	3	08f70e5103c6dd96f439f0cceda878963d26850d
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 TNKS1BP1 PTGS1	6.23e-04	187	40	3	3548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 TNKS1BP1 PTGS1	6.23e-04	187	40	3	f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|lymph-node_spleen / Manually curated celltypes from each tissue	MKI67 ERCC2 RRP12	6.23e-04	187	40	3	3c10b8501226c69d71bcd99dc1c064a3c2154f87
ToppCell	droplet-Marrow-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MKI67 ATP2A3 PTGS1	6.23e-04	187	40	3	14c239af77116d28d511dea754b6150d20488080
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLL4 SH3RF3 PREX1	6.23e-04	187	40	3	35c382c0aabd46906113e5db30ea24bb8e658899
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Endothelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 TNKS1BP1 PTGS1	6.23e-04	187	40	3	81754e965848b718be20ee97ce072ce426938a69
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Adult / Lineage, Cell type, age group and donor	DLL4 SH3RF3 PREX1	6.33e-04	188	40	3	e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLL4 ATP2A3 PREX1	6.33e-04	188	40	3	c2c51c6526defe2600302901159b8abbb58d7595
ToppCell	PCW_05-06-Endothelial-Endothelial_immature-endo_immature4_(5)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	DLL4 SH3RF3 PREX1	6.33e-04	188	40	3	b9c5d573fc5ab0f7f38c55d006f9576634b05462
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLL4 ATP2A3 PREX1	6.43e-04	189	40	3	12b6f1c3bf526b90e112374bf937701f645c5780
ToppCell	Control-Myeloid-Monocytes\|Control / group, cell type (main and fine annotations)	RNF130 SIPA1L1 SBF2	6.43e-04	189	40	3	3335d16bd0ffa0c1ddd06d7da645299148130c3f
ToppCell	Control-B_intermediate-6\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ATP2A3 PREX1 AHNAK	6.43e-04	189	40	3	11cb9a16f1de8f60af2073ed7ea6d4f41c02f299
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP2A3 DTX1 SH3GL2	6.43e-04	189	40	3	039b1922c85aa749d6578583d9d41a4eef8a6ac4
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ATP2A3 PREX1 SIPA1L1	6.43e-04	189	40	3	7ccea2df93bb4b37417bbc8f6c85a61ece95211a
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB4 DLL4 ATP2A3	6.43e-04	189	40	3	2e43428f1ef9683c6f8c9897d46aa7d34bf9047f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLL4 ATP2A3 PREX1	6.53e-04	190	40	3	bf9bc57a605c7e3979bc4f7260e6fb92c3eb8690
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-conventional_dendritic_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RNF130 TCOF1 CRIP3	6.53e-04	190	40	3	4b25d49f033bbd326b47cf5602af3f0262cfc367
ToppCell	ILEUM-non-inflamed-(8)_Activated_fibroblasts\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TNKS1BP1 SH3RF3 PTGS1	6.53e-04	190	40	3	39fa110d19c97c7cac99f5fb91b26bc08e2f3b42
ToppCell	Control-Endothelial-VE_Venous\|Control / Disease state, Lineage and Cell class	EPHB4 SH3RF3 PTGS1	6.63e-04	191	40	3	617546cf4883dedf3323e03a53ba5adec334cf8e
ToppCell	LV-08._Macrophage\|World / Chamber and Cluster_Paper	RNF130 PREX1 SIPA1L1	6.63e-04	191	40	3	e7a0bc46ba9ba772636a583f3387748418e18832
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLL4 ATP2A3 PREX1	6.63e-04	191	40	3	b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DLL4 ATP2A3 PTGS1	6.63e-04	191	40	3	54f07e4de61735051498846afb44b1798bed8144
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DLL4 SH3RF3 PREX1	6.63e-04	191	40	3	1de0bdfd13bd930691564c2673f2e66393bc0255
ToppCell	droplet-Tongue-nan-3m-Epithelial-suprabasal_interpapillary\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM5B GRHL3 AHNAK	6.63e-04	191	40	3	abdd93b2313e635f75a750d051a6a01ddc4e2df9
ToppCell	Adult-Immune-monocyte-D175\|Adult / Lineage, Cell type, age group and donor	RNF130 PREX1 PTGS1	6.63e-04	191	40	3	cbebb4d9550fdcd606cb3685ac9546c6b73fd422
ToppCell	IPF-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	TCOF1 PTGS1 SIPA1L1	6.63e-04	191	40	3	9fda87fb6bc5b8b6c0214ec909ebbc9f3f65319b
ToppCell	P03-Endothelial-large_vessel_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EPHB4 DLL4 ATP2A3	6.63e-04	191	40	3	b680e0c35f1004be36f9f0680ae3c62952e2b607
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLL4 ATP2A3 PREX1	6.73e-04	192	40	3	bacbaef1f230051335f4433e55db07a161b96b4c
ToppCell	390C-Myeloid-Mast_cell\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ATP2A3 PTGS1 AHNAK	6.73e-04	192	40	3	201d430af1e4fee7bc03baf0aca17db26f6f439a
ToppCell	MS-Treg-exh_CD4\|MS / Condition, Cell_class and T cell subcluster	DIP2B ATP2A3 KIF1C	6.73e-04	192	40	3	c6722bf142c84ccedd99c1a3344085aecb4cbab4
ToppCell	facs-Thymus-Epithelium-24m-Endothelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 DLL4 PTGS1	6.73e-04	192	40	3	39afea574725ce0c67afdd79facdb34f819a828d
ToppCell	droplet-Kidney-nan-3m-Endothelial-fenestrated_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 DLL4 PTGS1	6.73e-04	192	40	3	85be54c2cba8eab4c6ef2a85a526f7a9db4cfe73
ToppCell	droplet-Kidney-nan-3m-Endothelial-Pecam____fenestrated_capillary_endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 DLL4 PTGS1	6.73e-04	192	40	3	31a9142d97b690992aabee1a181650deb1a44253
Disease	polycystic kidney disease (biomarker_via_orthology)	DLL4 MTOR PTGS1	2.20e-06	19	40	3	DOID:0080322 (biomarker_via_orthology)
Disease	Malignant neoplasm of breast	MKI67 EPHB4 KMT2D ZNF532 DLL4 ATP2A3 MTOR PTGS1 SIPA1L1	1.07e-05	1074	40	9	C0006142
Disease	interstitial cystitis (is_marker_for)	MKI67 MTOR	1.79e-05	5	40	2	DOID:13949 (is_marker_for)
Disease	hemangiopericytoma (is_marker_for)	EPHB4 DLL4	6.41e-05	9	40	2	DOID:264 (is_marker_for)
Disease	Mammary Carcinoma, Human	MKI67 EPHB4 KMT2D DLL4 MTOR PTGS1	7.08e-05	525	40	6	C4704874
Disease	Mammary Neoplasms, Human	MKI67 EPHB4 KMT2D DLL4 MTOR PTGS1	7.08e-05	525	40	6	C1257931
Disease	Mammary Neoplasms	MKI67 EPHB4 KMT2D DLL4 MTOR PTGS1	7.23e-05	527	40	6	C1458155
Disease	Breast Carcinoma	MKI67 EPHB4 KMT2D DLL4 MTOR PTGS1	8.10e-05	538	40	6	C0678222
Disease	breast cancer (is_marker_for)	MKI67 KMT2D DLL4 PTGS1	1.15e-04	185	40	4	DOID:1612 (is_marker_for)
Disease	esophagus squamous cell carcinoma (is_marker_for)	EPHB4 KDM5B KMT2D	1.40e-04	74	40	3	DOID:3748 (is_marker_for)
Disease	Neoplasm of uncertain or unknown behavior of bladder	ERCC2 MTOR	1.86e-04	15	40	2	C0496930
Disease	Benign neoplasm of bladder	ERCC2 MTOR	1.86e-04	15	40	2	C0154017
Disease	Carcinoma in situ of bladder	ERCC2 MTOR	1.86e-04	15	40	2	C0154091
Disease	Carcinoma of bladder	ERCC2 MTOR	2.70e-04	18	40	2	C0699885
Disease	Alzheimer's disease (is_marker_for)	ELK1 ERCC2 ACADVL PTGS1	4.02e-04	257	40	4	DOID:10652 (is_marker_for)
Disease	QRS-T angle	DPYSL5 PPP1R3B SIPA1L1	4.04e-04	106	40	3	EFO_0020097
Disease	lung small cell carcinoma (is_implicated_in)	KMT2D MTOR	6.62e-04	28	40	2	DOID:5409 (is_implicated_in)
Disease	Bladder Neoplasm	ERCC2 KMT2D MTOR	9.08e-04	140	40	3	C0005695
Disease	Malignant neoplasm of urinary bladder	ERCC2 KMT2D MTOR	9.27e-04	141	40	3	C0005684
Disease	breast cancer (is_implicated_in)	MKI67 KDM5B ERCC2	1.11e-03	150	40	3	DOID:1612 (is_implicated_in)
Disease	Colonic Neoplasms	MKI67 KDM5B MTOR	1.15e-03	152	40	3	C0009375
Disease	heart disease (implicated_via_orthology)	CNOT6 ATP2A3	1.22e-03	38	40	2	DOID:114 (implicated_via_orthology)
Disease	prostate cancer (is_marker_for)	KDM5B KMT2D PREX1	1.24e-03	156	40	3	DOID:10283 (is_marker_for)
Disease	transient cerebral ischemia (biomarker_via_orthology)	ELK1 DLL4 MTOR	1.26e-03	157	40	3	DOID:224 (biomarker_via_orthology)
Disease	colon cancer (biomarker_via_orthology)	MKI67 MTOR	1.29e-03	39	40	2	DOID:219 (biomarker_via_orthology)
Disease	Malignant tumor of colon	MKI67 KDM5B MTOR	1.31e-03	159	40	3	C0007102

Protein segments in the cluster

Peptide	Gene	Start	Entry
KPDVSHGEMVSGFGP	C4BPA	241	P04003
MSSPPEGKLETKAGH	DAP	1	P51397
TVSGKPGTPKGAGMA	ELK1	126	P19419
TMPGKFPHSDKSLGE	DLL4	626	Q9NR61
FSTPGAKGEGPDVHM	AHNAK	636	Q09666
PGKGGVPAHMFGVTK	ECD	66	O95905
TRPHPTGQGSKMFVK	ATP2A3	501	Q93084
KSKEEPVTMTHPGTG	RNF130	136	Q86XS8
QHMKSQAKPGTPGGT	EPHB4	966	P54760
GPSMGAPKHTSDKAF	SBF2	1801	Q86WG5
DLPPSGIVKGMHKGS	DIP2B	241	Q9P265
DGGTVGVFSPKKTPH	KIF1C	486	O43896
GHGVLEMPSGTGKTV	ERCC2	36	P18074
ATKMGFAPGKAVGSH	KDM5B	156	Q9UGL1
SAGKAMHTPKPSVGE	MKI67	1291	P46013
PSAGKAMHTPKPAVG	MKI67	1776	P46013
TSGKMGPGFTKALGH	PTGS1	211	P23219
GEKTGTQPPGKMEFH	DTX1	476	Q86Y01
GSPKAIHIKSGESPM	GRHL3	236	Q8TE85
FSPIMSSPSGKKGAH	HEATR4	1011	Q86WZ0
QGKKSPPHMKTFTGE	CRIP3	106	Q6Q6R5
KESIEMPSGKPHLGT	CNOT6	336	Q9ULM6
MGKEDFTKIPHGVSG	DPYSL5	336	Q9BPU6
QIPKGTVMVGKPSSH	MED1	1066	Q15648
ELKSTQGMTKPHSGP	PPP1R3B	236	Q86XI6
ASGPVETGPMKKLHV	MTOR	1246	P42345
GPPGGEMTFSIPTHK	KHSRP	421	Q92945
VKGPGKMSHSSSGPA	SUPT20HL1	416	Q3ZLR7
KAGKTGNSMPHPATG	TCOF1	131	Q13428
GSPVYMKGVTKSGIP	NDUFAF7	181	Q7L592
MKSFVHPKPGAAGSV	PREX1	1546	Q8TCU6
GSHHITSTPGVPKMG	SIPA1L1	61	O43166
GSGIHRPVAKKAMPG	RRP12	1216	Q5JTH9
VKGPGKMSHSSSGPA	SUPT20HL2	416	P0C7V6
RGFGGITHGPPEKKM	ACADVL	286	P49748
KSMHGTLKSIEGPPN	ZNF532	956	Q9HCE3
GLSHTGTPKPSGVQM	SH3GL2	276	Q99962
GSPLAKGITTTMHPG	SH3RF3	541	Q8TEJ3
SKMEGGHFVPPGKTT	TNKS1BP1	1141	Q9C0C2
HAMKRKPEGGPSFSQ	ZNF445	731	P59923
PKGGHVTSMQPKEPG	KMT2D	396	O14686