Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylcholine receptor regulator activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE16	7.39e-11	27	105	7	GO:0030548
GeneOntologyMolecularFunction	neurotransmitter receptor regulator activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE16	9.81e-11	28	105	7	GO:0099602
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE1 SYNE2	2.71e-04	5	105	2	GO:0140444
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein serine/threonine kinase activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE4 PSRC1 SPDYE6 SPDYE16	2.96e-13	25	103	8	GO:0045737
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein kinase activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE4 PSRC1 SPDYE6 SPDYE16	8.39e-13	28	103	8	GO:1904031
GeneOntologyBiologicalProcess	regulation of cyclin-dependent protein serine/threonine kinase activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE4 PSRC1 SPDYE6 SPDYE16	2.71e-08	96	103	8	GO:0000079
GeneOntologyBiologicalProcess	regulation of cyclin-dependent protein kinase activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE4 PSRC1 SPDYE6 SPDYE16	3.74e-08	100	103	8	GO:1904029
GeneOntologyBiologicalProcess	positive regulation of cell cycle	SPDYE1 RAD18 RB1 CAMK2B PAF1 SPDYE2 SPDYE5 SPDYE2B SPDYE4 PSRC1 SPDYE6 SPDYE16	8.99e-07	407	103	12	GO:0045787
GeneOntologyBiologicalProcess	positive regulation of protein serine/threonine kinase activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE4 PSRC1 SPDYE6 SPDYE16	5.66e-06	193	103	8	GO:0071902
GeneOntologyBiologicalProcess	positive regulation of transferase activity	SPDYE1 ERBB3 NAF1 SPDYE2 DLG4 SPDYE5 SPDYE2B SPDYE4 PSRC1 SPDYE6 SPDYE16	3.39e-05	490	103	11	GO:0051347
GeneOntologyBiologicalProcess	positive regulation of kinase activity	SPDYE1 ERBB3 SPDYE2 DLG4 SPDYE5 SPDYE2B SPDYE4 PSRC1 SPDYE6 SPDYE16	3.54e-05	405	103	10	GO:0033674
GeneOntologyBiologicalProcess	positive regulation of protein kinase activity	SPDYE1 SPDYE2 DLG4 SPDYE5 SPDYE2B SPDYE4 PSRC1 SPDYE6 SPDYE16	6.51e-05	350	103	9	GO:0045860
GeneOntologyBiologicalProcess	regulation of protein serine/threonine kinase activity	SPDYE1 RB1 SPDYE2 SPDYE5 SPDYE2B SPDYE4 PSRC1 SPDYE6 SPDYE16	7.74e-05	358	103	9	GO:0071900
Domain	Spy1	SPDYE1 SPDYE2 SPDYE21 SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE16	1.45e-16	11	107	8	PF11357
Domain	Speedy	SPDYE1 SPDYE2 SPDYE21 SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE16	1.45e-16	11	107	8	IPR020984
Domain	NBPF_dom	NBPF3 NBPF11 NBPF15 NBPF9 NBPF14	2.52e-09	11	107	5	IPR010630
Domain	NBPF	NBPF3 NBPF11 NBPF15 NBPF9 NBPF14	2.52e-09	11	107	5	PS51316
Domain	DUF1220	NBPF3 NBPF11 NBPF15 NBPF9 NBPF14	2.52e-09	11	107	5	PF06758
Domain	DUF1220	NBPF3 NBPF11 NBPF15 NBPF9	1.25e-07	9	107	4	SM01148
Domain	KASH	SYNE1 SYNE2	1.94e-04	4	107	2	PF10541
Domain	KASH	SYNE1 SYNE2	1.94e-04	4	107	2	IPR012315
Domain	KASH	SYNE1 SYNE2	1.94e-04	4	107	2	PS51049
Domain	KASH	SYNE1 SYNE2	1.94e-04	4	107	2	SM01249
Domain	Actinin_actin-bd_CS	SYNE1 SYNE2 DMD	2.98e-04	23	107	3	IPR001589
Domain	Spectrin	SYNE1 SYNE2 DMD	2.98e-04	23	107	3	PF00435
Domain	ACTININ_2	SYNE1 SYNE2 DMD	2.98e-04	23	107	3	PS00020
Domain	ACTININ_1	SYNE1 SYNE2 DMD	2.98e-04	23	107	3	PS00019
Domain	Alpha_kinase	TRPM6 ALPK2	4.80e-04	6	107	2	PF02816
Domain	ALPHA_KINASE	TRPM6 ALPK2	4.80e-04	6	107	2	PS51158
Domain	Alpha_kinase	TRPM6 ALPK2	4.80e-04	6	107	2	SM00811
Domain	MHCK_EF2_kinase	TRPM6 ALPK2	4.80e-04	6	107	2	IPR004166
Domain	CH	SYNE1 EHBP1L1 SYNE2 DMD	5.27e-04	65	107	4	SM00033
Domain	Spectrin_repeat	SYNE1 SYNE2 DMD	5.99e-04	29	107	3	IPR002017
Domain	CH	SYNE1 EHBP1L1 SYNE2 DMD	6.98e-04	70	107	4	PF00307
Domain	-	SYNE1 EHBP1L1 SYNE2 DMD	7.37e-04	71	107	4	1.10.418.10
Domain	Spectrin/alpha-actinin	SYNE1 SYNE2 DMD	8.03e-04	32	107	3	IPR018159
Domain	SPEC	SYNE1 SYNE2 DMD	8.03e-04	32	107	3	SM00150
Domain	CH	SYNE1 EHBP1L1 SYNE2 DMD	8.18e-04	73	107	4	PS50021
Domain	CH-domain	SYNE1 EHBP1L1 SYNE2 DMD	9.05e-04	75	107	4	IPR001715
Domain	WW	FNBP4 PQBP1 DMD	2.47e-03	47	107	3	PF00397
Domain	WW	FNBP4 PQBP1 DMD	2.62e-03	48	107	3	SM00456
Domain	WW_DOMAIN_2	FNBP4 PQBP1 DMD	3.12e-03	51	107	3	PS50020
Domain	WW_DOMAIN_1	FNBP4 PQBP1 DMD	3.12e-03	51	107	3	PS01159
Domain	WW_dom	FNBP4 PQBP1 DMD	3.30e-03	52	107	3	IPR001202
Pubmed	Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE16	1.13e-16	9	113	7	36272447
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF3 NBPF11 NBPF20 NBPF19 NBPF15 NBPF9 NBPF10 NBPF14	1.90e-15	21	113	8	16079250
Pubmed	Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE16	5.34e-15	13	113	7	15611625
Pubmed	Characterization of a new family of cyclin-dependent kinase activators.	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE16	5.99e-14	17	113	7	15574121
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NES DMXL2 KIFBP LIMA1 MIA3 FOXP2 CAMK2B SYNE1 DNAJA2 SH3KBP1 ARHGEF12 PAF1 ZC3H4 SYNE2 DLG4 TAF5 CNOT1 ATP2B4 RAI1	3.09e-10	963	113	19	28671696
Pubmed	SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.	NES SYNE1 DNAI1 SYNE2	1.03e-07	14	113	4	19874786
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SLAIN2 RAD18 SUPT20H FOXP2 RB1 DNAJA2 CHD3 DAP3 EAF1 ZC3H4 NAF1 DLG4 TAF5 TADA3 TOP1 RAI1 FTSJ3	1.25e-07	1116	113	17	31753913
Pubmed	Human transcription factor protein interaction networks.	LIMA1 RAD18 SUPT20H ARID3A FOXP2 RB1 DNAJA2 SH3KBP1 CHD3 STAT2 PRDM2 DAP3 LMO2 SYNE2 TAF5 TADA3 CNOT1 TOP1 FTSJ3	1.74e-07	1429	113	19	35140242
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ZC3H14 NES LIMA1 HYOU1 SYNE1 CHD3 PQBP1 DHX8 SAFB ZC3H4 SLC20A1 SYNE2 CKAP2L CNOT1 TOP1 FTSJ3	2.18e-07	1024	113	16	24711643
Pubmed	Radmis, a novel mitotic spindle protein that functions in cell division of neural progenitors.	NES CKAP2L DLX2	6.63e-07	6	113	3	24260314
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	NES DENND2A DMXL2 LIMA1 HYOU1 CAMK2B SYNE1 DNAJA2 SH3KBP1 ARHGEF12 OAT CHD3 SAFB DLG4 DMD CNOT1 ATP2B4 TOP1	8.48e-07	1431	113	18	37142655
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	LIMA1 FOXP2 DNAJA2 ZFP14 NBPF11 NBPF15 NBPF9 NBPF10 NBPF14 TOP1 ALPK2	9.71e-07	513	113	11	25798074
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ZC3H14 RAD18 SUPT20H DNAJA2 FNBP4 JDP2 CHD3 PAF1 PQBP1 PRDM2 DHX8 SAFB TAF5 TADA3 TOP1 RAI1 FTSJ3	9.82e-07	1294	113	17	30804502
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	LIMA1 CHD3 NBPF11 NBPF9 SYNE2 NBPF10 NBPF14	1.47e-06	170	113	7	23314748
Pubmed	The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation.	NES CAMK2B ARHGEF12 DLG4	2.04e-06	28	113	4	24448406
Pubmed	Gene expression analysis of the embryonic subplate.	NES FOXP2 LMO2 SYNE2 ROBO2 CDH12 SLC17A6	3.78e-06	196	113	7	21862448
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF15 NBPF9 NBPF14	3.94e-06	10	113	3	22973535
Pubmed	Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex.	DMXL2 FOXP2 DLG4 SLC17A6	5.12e-06	35	113	4	37758766
Pubmed	Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming.	FOXP2 DLG4 SLC17A6	5.41e-06	11	113	3	36030255
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DMXL2 KIFBP MIA3 HYOU1 ATP13A1 SYNE1 DNAJA2 FNBP4 OAT PAF1 DAP3 STX18 SLC20A1 SYNE2 TADA3 ATP2B4 FTSJ3	6.32e-06	1487	113	17	33957083
Pubmed	The tumor suppressor Pml regulates cell fate in the developing neocortex.	NES FOXP2 RB1	9.33e-06	13	113	3	19136970
Pubmed	KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.	SYNE1 DNAI1 SYNE2	9.33e-06	13	113	3	21177258
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ZC3H14 NES HYOU1 OAT BIRC6 DHX8 SYNE2 CNOT1 TOP1 RAI1 FTSJ3	9.68e-06	653	113	11	22586326
Pubmed	Plasma membrane Ca2+ ATPase isoform 4b binds to membrane-associated guanylate kinase (MAGUK) proteins via their PDZ (PSD-95/Dlg/ZO-1) domains.	DLG4 ATP2B4	1.05e-05	2	113	2	9430700
Pubmed	Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.	SYNE1 SYNE2	1.05e-05	2	113	2	11792814
Pubmed	Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.	SYNE1 SYNE2	1.05e-05	2	113	2	24931616
Pubmed	Voltage-gated sodium channel (SkM1) content in dystrophin-deficient muscle.	SCN4A DMD	1.05e-05	2	113	2	11316257
Pubmed	Overexpression of a calpastatin transgene in mdx muscle reduces dystrophic pathology.	CAST DMD	1.05e-05	2	113	2	12354790
Pubmed	The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein.	RB1 PRDM2	1.05e-05	2	113	2	7538672
Pubmed	PSD-95 mediates membrane clustering of the human plasma membrane Ca2+ pump isoform 4b.	DLG4 ATP2B4	1.05e-05	2	113	2	19073225
Pubmed	Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.	SYNE1 SYNE2	1.05e-05	2	113	2	22768332
Pubmed	Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.	SYNE1 SYNE2	1.05e-05	2	113	2	17267447
Pubmed	Nesprins: tissue-specific expression of epsilon and other short isoforms.	SYNE1 SYNE2	1.05e-05	2	113	2	24718612
Pubmed	Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.	SYNE1 SYNE2	1.05e-05	2	113	2	24586179
Pubmed	Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.	SYNE1 SYNE2	1.05e-05	2	113	2	17761684
Pubmed	Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.	SYNE1 SYNE2	1.05e-05	2	113	2	31578382
Pubmed	Talin, vinculin and nestin expression in orofacial muscles of dystrophin deficient mdx mice.	NES DMD	1.05e-05	2	113	2	22307364
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ZC3H14 RAD18 CAST FNBP4 CHD3 PAF1 PQBP1 SAFB ZC3H4 TADA3 TOP1 RAI1 FTSJ3	1.41e-05	954	113	13	36373674
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	SLAIN2 ZC3H14 ARID3A HYOU1 JDP2 CHD3 PAF1 PQBP1 PRDM2 SAFB TADA3 CNOT1 TOP1 RAI1	1.42e-05	1103	113	14	34189442
Pubmed	A mutation in Tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse.	NES FOXP2 DLX2	1.48e-05	15	113	3	23727838
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TRPM6 KIFBP HYOU1 ATP13A1 CAMK2B SYNE1 DNAJA2 OAT LAMC3 PRDM2 DHX8 DAP3 SAFB CNOT1 TOP1 FTSJ3	1.52e-05	1425	113	16	30948266
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ZC3H14 HYOU1 DNAJA2 CAST PAF1 PQBP1 DHX8 ZC3H4 TADA3 CNOT1 TOP1	2.51e-05	724	113	11	36232890
Pubmed	A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.	KIFBP HYOU1 DNAJA2 SH3KBP1 TMOD4 DYNC2I1 DHX8 SYNE2	2.57e-05	363	113	8	25036637
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	NES MIA3 HYOU1 ATP13A1 DNAJA2 DYNC2I1 BIRC6 STAT2 DHX8 SLC20A1 SH3BP5L	2.81e-05	733	113	11	34672954
Pubmed	Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes.	NES FOXP2 DMD	3.12e-05	19	113	3	22028625
Pubmed	Evolution of the Cdk-activator Speedy/RINGO in vertebrates.	SPDYE2 SPDYE6	3.13e-05	3	113	2	22763696
Pubmed	A Disynaptic Circuit in the Globus Pallidus Controls Locomotion Inhibition.	FOXP2 SLC17A6	3.13e-05	3	113	2	33306949
Pubmed	The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.	SYNE1 SYNE2	3.13e-05	3	113	2	16079285
Pubmed	In vitro analysis of the E1A-homologous sequences of RIZ.	RB1 PRDM2	3.13e-05	3	113	2	9223517
Pubmed	SLY1 and Syntaxin 18 specify a distinct pathway for procollagen VII export from the endoplasmic reticulum.	MIA3 STX18	3.13e-05	3	113	2	24842878
Pubmed	Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.	SYNE1 SYNE2	3.13e-05	3	113	2	10878022
Pubmed	Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci.	RB1 DNAJA2	3.13e-05	3	113	2	17242198
Pubmed	Nestin expression in end-stage disease in dystrophin-deficient heart: implications for regeneration from endogenous cardiac stem cells.	NES DMD	3.13e-05	3	113	2	24068741
Pubmed	The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.	SYNE1 SYNE2	3.13e-05	3	113	2	12408964
Pubmed	Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.	SYNE1 SYNE2	3.13e-05	3	113	2	17462627
Pubmed	Chloride channelopathy in myotonic dystrophy resulting from loss of posttranscriptional regulation for CLCN1.	SCN4A DMD	3.13e-05	3	113	2	17135300
Pubmed	Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.	SYNE1 SYNE2	3.13e-05	3	113	2	33472039
Pubmed	Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.	SYNE1 SYNE2	3.13e-05	3	113	2	25516977
Pubmed	The LMO2 oncogene regulates DNA replication in hematopoietic cells.	HYOU1 LMO2 CKAP2L RAI1	3.91e-05	58	113	4	26764384
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	ZC3H14 LIMA1 HYOU1 DNAJA2 OAT PQBP1 DHX8 DAP3 SAFB TAF5 TOP1	5.27e-05	786	113	11	29128334
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SLAIN2 DENND2A KIFBP FNBP4 ADGRV1 ZC3H4 ROBO2 CNOT1 RAI1	5.99e-05	529	113	9	14621295
Pubmed	SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.	SYNE1 SYNE2	6.25e-05	4	113	2	16648470
Pubmed	IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses.	ARHGEF12 DLG4	6.25e-05	4	113	2	18164504
Pubmed	Efferent projections of Vglut2, Foxp2, and Pdyn parabrachial neurons in mice.	FOXP2 SLC17A6	6.25e-05	4	113	2	32621762
Pubmed	Differential Synaptic Input to External Globus Pallidus Neuronal Subpopulations In Vivo.	FOXP2 SLC17A6	6.25e-05	4	113	2	33248017
Pubmed	Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.	SYNE1 SYNE2	6.25e-05	4	113	2	28716842
Pubmed	LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.	SYNE1 SYNE2	6.25e-05	4	113	2	23071752
Pubmed	Isolation and characterization of a library of cDNA clones that are preferentially expressed in the embryonic telencephalon.	DLX2 TOP1	6.25e-05	4	113	2	1372074
Pubmed	Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.	SYNE1 SYNE2	6.25e-05	4	113	2	20108321
Pubmed	Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.	SYNE1 SYNE2	6.25e-05	4	113	2	19596800
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	ZC3H14 SYNE1 DHX8 DAP3 SAFB ZC3H4 NAF1 NBPF10 CNOT1 TOP1 FTSJ3	6.66e-05	807	113	11	22681889
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DMXL2 ERBB3 SUPT20H ATP13A1 SYNE1 DNAJA2 DYNC2I1 OAT UBA7 STX18 LMO2 SCG2 DLG4 TOP1	7.47e-05	1285	113	14	35914814
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	DMXL2 SYNE1 ADGRV1 BIRC6 ZC3H4 SYNE2	9.74e-05	225	113	6	12168954
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	ZC3H14 LIMA1 ARID3A DNAJA2 FNBP4 SAFB NAF1 TAF5 TOP1 FTSJ3	1.00e-04	701	113	10	30196744
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	KIFBP MIA3 HYOU1 SYNE1 DNAJA2 DYNC2I1 OAT BIRC6 AK3 DAP3 STX18 ZC3H4 SYNE2 TOP1 FTSJ3	1.03e-04	1496	113	15	32877691
Pubmed	Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.	FOXP2 CAMK2B DLG4	1.03e-04	28	113	3	31600191
Pubmed	The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.	SUPT20H TAF5 TADA3	1.03e-04	28	113	3	19114550
Pubmed	LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.	SYNE1 SYNE2	1.04e-04	5	113	2	22632968
Pubmed	Polymorphisms of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disorders.	FOXP2 DLX2	1.04e-04	5	113	2	19018235
Pubmed	Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.	SYNE1 SYNE2	1.04e-04	5	113	2	18396275
Pubmed	Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular junctions.	NES DMD	1.04e-04	5	113	2	17953659
Pubmed	A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts.	RB1 LMO2	1.04e-04	5	113	2	10866689
Pubmed	Sox2 transcriptionally regulates PQBP1, an intellectual disability-microcephaly causative gene, in neural stem progenitor cells.	NES PQBP1	1.04e-04	5	113	2	23874697
Pubmed	Anatomical Development of the Cerebellothalamic Tract in Embryonic Mice.	FOXP2 SLC17A6	1.04e-04	5	113	2	36497060
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	ZC3H14 DNAJA2 OAT DHX8 DAP3 SAFB ZC3H4 NAF1 TOP1 FTSJ3	1.15e-04	713	113	10	29802200
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	ZC3H14 LIMA1 HYOU1 SYNE1 CHD3 PQBP1 DHX8 DAP3 SAFB TOP1	1.16e-04	714	113	10	28302793
Pubmed	A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.	SUPT20H TAF5 TADA3	1.27e-04	30	113	3	18206972
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RAD18 SUPT20H RB1 CAMK2B DNAJA2 PAF1 PQBP1 STAT2 SH3BP5L	1.33e-04	588	113	9	38580884
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	SYNE1 SH3KBP1 ADGRV1 ACTL7B STX18	1.43e-04	152	113	5	34299191
Pubmed	ELF a beta-spectrin is a neuronal precursor cell marker in developing mammalian brain; structure and organization of the elf/beta-G spectrin gene.	NES DMD	1.56e-04	6	113	2	12149647
Pubmed	CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.	SH3KBP1 DLG4	1.56e-04	6	113	2	20551902
Pubmed	SETDB1 Modulates Degradation of Phosphorylated RB and Anticancer Efficacy of CDK4/6 Inhibitors.	RB1 CHD3	1.56e-04	6	113	2	36637424
Pubmed	Generation of mice with a conditional Foxp2 null allele.	FOXP2 DLX2	1.56e-04	6	113	2	17619227
Pubmed	Dynamic regulation of alternative polyadenylation by PQBP1 during neurogenesis.	NES PQBP1	1.56e-04	6	113	2	39037895
Pubmed	Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.	SYNE1 SYNE2	1.56e-04	6	113	2	33058875
Pubmed	TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.	SYNE1 SYNE2	1.56e-04	6	113	2	18827015
Pubmed	Genetic mapping of DNA topoisomerase I-related sequences to mouse chromosomes 2 and 14.	RB1 TOP1	1.56e-04	6	113	2	8012118
Pubmed	Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins.	DLG4 ATP2B4	1.56e-04	6	113	2	11274188
Pubmed	Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study.	MIA3 PSRC1	1.56e-04	6	113	2	19955471
Pubmed	Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing.	STAT2 UBA7	1.56e-04	6	113	2	31974171
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	TMOD4 NBPF11 NBPF20 NBPF19 NBPF15 NBPF9 NBPF10 NBPF14	8.20e-06	404	114	8	chr1q21
Cytoband	1q21.1	NBPF11 NBPF9 NBPF10 NBPF14	1.80e-05	62	114	4	1q21.1
GeneFamily	Neuroblastoma breakpoint family	NBPF3 NBPF11 NBPF20 NBPF19 NBPF15 NBPF9 NBPF10 NBPF14	8.69e-14	23	86	8	662
GeneFamily	Speedy/RINGO cell cycle regulator family	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE4 SPDYE6	8.76e-12	12	86	6	756
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE1 SYNE2	1.33e-04	4	86	2	1252
GeneFamily	X-linked mental retardation\|Angiotensin receptors	NEXMIF PQBP1 DMD	2.05e-03	53	86	3	103
GeneFamily	Lysine acetyltransferases\|ATAC complex\|SAGA complex\|GCN5 related N-acetyltransferases	SUPT20H TADA3	2.90e-03	17	86	2	1059
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NES DENND2A SH3KBP1 CAST ARHGEF12 LAMC3 LURAP1L	5.68e-07	190	113	7	10125091ad648163777b02e9f0d5e8d7f17d44a5
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Cortical_neuron\|10w / Sample Type, Dataset, Time_group, and Cell type.	FOXP2 FAM13C CAMK2B CHD3 SCG2 ROBO2 SLC17A6	8.01e-07	200	113	7	68c90376e2779434e4ad8dc6dd3b44baa700e2f4
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NES DENND2A FAM13C LAMC3 LURAP1L DMD	6.90e-06	181	113	6	451b87ac95154bb80018b8dd245b4a6389d81411
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon\|organoid_Paulsen_bioRxiv / Sample Type, Dataset, Time_group, and Cell type.	NES LIMA1 ADGRV1 LMO2 DLX2 PSRC1	1.12e-05	197	113	6	58b957efd006f43c2fe55071d5c6d06c2e367e72
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Smooth_muscle-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	NES DENND2A FAM13C LAMC3 SYNE2 DMD	1.22e-05	200	113	6	0c648941447c738caf62f2d71e296d6cca492c8b
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NES DENND2A FAM13C LAMC3 SYNE2 DMD	1.22e-05	200	113	6	522a51a284d2992d519c4669e1a48c8ebcc08c80
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	NES DENND2A FAM13C LAMC3 SYNE2 DMD	1.22e-05	200	113	6	94f1fa61aa82eb9f411b2b1cb759476939ab5db7
Disease	progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian carcinoma	FOXP2 ROBO2 DMD ATP2B4	7.93e-06	39	96	4	EFO_0001075, EFO_0004920, GO_0097328, MONDO_0009354
Disease	Apraxia of Phonation	FOXP2 CHD3	3.14e-05	3	96	2	C0264611
Disease	Autosomal dominant Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	6.26e-05	4	96	2	cv:CN293514
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	1.04e-04	5	96	2	C1450051
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE1 SYNE2	1.04e-04	5	96	2	C0410190
Disease	Intellectual Disability	ZC3H14 KIFBP CAMK2B SYNE1 CHD3 PQBP1 DLG4 RAI1	1.08e-04	447	96	8	C3714756
Disease	Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	1.56e-04	6	96	2	cv:C0410189
Disease	age at diagnosis, substance-related disorder	FOXP2 BIRC6	1.56e-04	6	96	2	EFO_0004918, MONDO_0002494
Disease	anti-drug antibody measurement	PRDM2 DNAI1	1.56e-04	6	96	2	EFO_0010559
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE1 SYNE2	1.56e-04	6	96	2	C0410189
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	2.18e-04	7	96	2	C0751337
Disease	fasting blood glucose measurement	KIF6 PDE6C CAMK2B CAST JDP2 TOP1	3.58e-04	287	96	6	EFO_0004465
Disease	free cholesterol measurement	FNBP4 DLG4 TOP1 PSRC1	5.16e-04	113	96	4	EFO_0008591
Disease	unipolar depression, sex interaction measurement	CAST LMO2 SCG2	6.21e-04	51	96	3	EFO_0003761, EFO_0008343
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 SYNE2	6.77e-04	12	96	2	DOID:11726 (implicated_via_orthology)
Disease	angina pectoris	MIA3 ARHGEF12 EHBP1L1 PSRC1	7.55e-04	125	96	4	EFO_0003913
Disease	osteoarthritis	FOXP2 CAMK2B PRDM2 LURAP1L ALPK2	8.08e-04	222	96	5	MONDO_0005178
Disease	Neoplasm of uncertain or unknown behavior of bladder	ERBB3 RB1	1.07e-03	15	96	2	C0496930
Disease	Benign neoplasm of bladder	ERBB3 RB1	1.07e-03	15	96	2	C0154017
Disease	Carcinoma in situ of bladder	ERBB3 RB1	1.07e-03	15	96	2	C0154091
Disease	body fat percentage	DMXL2 ERBB3 HYOU1 CAST MFAP3 ZC3H4 ATP2B4	1.09e-03	488	96	7	EFO_0007800
Disease	phosphorus measurement	NBPF3 FGF23	1.22e-03	16	96	2	EFO_0004861
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	ERBB3 HYOU1 CAST MFAP3 ZC3H4 ATP2B4	1.23e-03	364	96	6	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	Carcinoma of bladder	ERBB3 RB1	1.55e-03	18	96	2	C0699885
Disease	autism spectrum disorder (implicated_via_orthology)	NEXMIF LAMC3 DLG4 NAA16	1.56e-03	152	96	4	DOID:0060041 (implicated_via_orthology)
Disease	intellectual disability (implicated_via_orthology)	ZC3H14 RB1 NAA16	1.90e-03	75	96	3	DOID:1059 (implicated_via_orthology)
Disease	brain connectivity measurement	ERBB3 KIF6 FOXP2 SH3KBP1 ADGRV1 ROBO2	1.99e-03	400	96	6	EFO_0005210
Disease	Nasopharyngeal carcinoma	ERBB3 SYNE1	2.32e-03	22	96	2	C2931822
Disease	post-traumatic stress disorder symptom measurement	FOXP2 SYNE1 UBA7	2.45e-03	82	96	3	EFO_0008535
Disease	Autism Spectrum Disorders	LAMC3 DLG4 RAI1	2.72e-03	85	96	3	C1510586
Disease	waist circumference	FAM178B CAST ZC3H4 SYNE2 DMD CDH12	2.81e-03	429	96	6	EFO_0004342
Disease	testosterone measurement	TRPM6 LIMA1 MIA3 YIPF4 CAST FNBP4 BIRC6 ZC3H4 SYNE2 ATP2B4 RAI1	2.88e-03	1275	96	11	EFO_0004908
Disease	age at menopause	RAD18 ARID3A YIPF4 BIRC6 SLC26A8	3.11e-03	302	96	5	EFO_0004704
Disease	serum albumin measurement	MIA3 SH3KBP1 ADGRV1 ZBTB46 EHBP1L1 DLG4 XKR5	3.23e-03	592	96	7	EFO_0004535
Disease	response to norepinephrine-dopamine reuptake inhibitor	ADGRV1 ROBO2	3.24e-03	26	96	2	EFO_0007870

Protein segments in the cluster

Peptide	Gene	Start	Entry
RTLEELLKPPEDEAE	TADA3	171	O75528
LERGESIEPLDPSEK	ERBB3	681	P21860
PEEELGLVPEELRVD	ACTL7B	266	Q9Y614
IDPLDIDLEKDPLAA	BIRC6	2496	Q9NR09
AKLSPREEEELDPRI	SH3BP5L	46	Q7L8J4
PRLLESSVDPVDEKE	ALPK2	1336	Q86TB3
KEPIEDLSPDRVLDL	ATP13A1	361	Q9HD20
LLLEKPDEPDILDDL	FAM47DP	336	A6NHR8
ITVEILPDEDPELDK	ADGRV1	1931	Q8WXG9
DIPTDDIDLEPEKRE	DMXL2	1476	Q8TDJ6
PPDQLELTDAELKEE	DNAI1	51	Q9UI46
EEPLGPDLEDLKRQV	DMD	476	P11532
NEPEKEDLEPEIRIV	DLX2	131	Q07687
TIRDPEKPNTLEELE	CIAO2A	46	Q9H5X1
PEPQLDDIKRELRAE	EAF1	166	Q96JC9
EELPRTPLLDEEEEE	ATP2B4	1176	P23634
ADLEKRRPELIPEDL	ARHGEF12	446	Q9NZN5
ERKSLDPSEEPVDEV	LMO2	6	P25791
DLPLVRLEFEETEEP	RB1	41	P06400
LPPTSRKEDLEAEEE	RAI1	856	Q7Z5J4
KLDSPEELEPDREED	RAD18	406	Q9NS91
PAPELDRFEELVKEI	C22orf23	151	Q9BZE7
EISKPEVPEDVDLDL	LIMA1	561	Q9UHB6
PQPVKSELDEEEERR	JDP2	61	Q8WYK2
EPLIQREDDKPETVI	AK3	156	Q9UIJ7
SNEPESREKLEELPL	DYNC2I1	396	Q8WVS4
VAILKEDLPDPRSAE	PDE6C	491	P51160
ELIPEKLERVENPLE	NAA16	641	Q6N069
SPELEDDREIEEEPL	FOXP2	696	O15409
PDPSRELKTLCEEEE	EHBP1L1	211	Q8N3D4
EPPLEEESLEAKRVQ	NES	1121	P48681
LEDLPKVTILEDPDQ	KIF6	166	Q6ZMV9
LGPLSPEKLEEILDE	PSRC1	66	Q6PGN9
VELQKLLEPEPEEDA	PSMB11	246	A5LHX3
VDDPDDLGERIKERP	MFAP3	261	P55082
LKRVDDEEDTVAPLP	PKD1L2	1886	Q7Z442
ILKHLEPEPEEEIIA	PQBP1	16	O60828
SPRLSRELLDEKEPE	NBPF3	401	Q9H094
DPADEKLLEEEIQAP	PAF1	101	Q8N7H5
DKLSELEDLLPSRPE	DNAJA2	346	O60884
VELVVLDLPDLPEDK	HYOU1	701	Q9Y4L1
RPVDIPEDELEEIRE	CABP7	26	Q86V35
DLEGREPTPELVEDR	DENND2A	221	Q9ULE3
LGERLEPRKIPLEDE	CHD3	1606	Q12873
AEDDSERDPLNVLKP	FGF23	181	Q9GZV9
PVAKDLLGEEDIPRE	DLG4	296	P78352
DREKLGEKEETIPPD	CAST	466	P20810
MEDSPLPDLRDIELK	LURAP1L	1	Q8IV03
AVDIETRKPLEPESE	CDH12	131	P55289
EVPLDLPADSRKEDE	SLC13A3	211	Q8WWT9
EAPERERLPSVDLKE	SLC20A1	326	Q8WUM9
LDPTERFLPEEEKLT	KIFBP	181	Q96EK5
DLEIELVEEEPPFLR	DHX8	436	Q14562
KEPEIRCDEKPEDLL	PRDM2	306	Q13029
RCDEKPEDLLEEPKT	PRDM2	311	Q13029
LDKALDPEEQPELSL	PCDHB3	196	Q9Y5E6
REDKSPIAPEELALV	DAP3	276	P51398
LLKEPEIEVPLDDED	TAF5	376	Q15542
TIEDEDAKAPRVPDI	CAMK2B	401	Q13554
LVTPEDDELDELRPG	VAC14	331	Q08AM6
ELKPEPELESLELEL	STAT2	711	P52630
LDEVEPLRPDELERL	SLAIN2	106	Q9P270
EIEEPERKPRSDLEA	SCN4A	46	P35499
GIPRLLDPEDVDVDK	SYNE1	251	Q8NF91
QELKIPRLLEPEDVD	SYNE2	251	Q8WXH0
DEIDLPRELEDEVPI	MIA3	636	Q5JRA6
LAPLLPEGIKEEEER	FNBP4	326	Q8N3X1
PRLSRELLDEKEPEV	NBPF9	861	P0DPF3
PRLSRELLDEKEPEV	NBPF10	936	Q6P3W6
PRLSRELLDEKEPEV	NBPF10	2156	Q6P3W6
PRLSRELLDEKEPEV	NBPF10	3376	Q6P3W6
GPRLSRELLDEKEPE	NBPF11	616	Q86T75
PRLSGELLDEKEPEV	NBPF14	596	Q5TI25
PRLSRELLDEKEPEV	NBPF14	671	Q5TI25
PRLSRELLDEKEPEV	NBPF15	346	Q8N660
PRLSRELLDEKEPEV	NBPF15	421	Q8N660
PRLSRELLDEKEPEV	NBPF19	421	A0A087WUL8
PRLSRELLDEKEPEV	NBPF19	1641	A0A087WUL8
PRLSRELLDEKEPEV	NBPF19	2861	A0A087WUL8
LAEKEPEVLQDPLDR	NBPF19	3356	A0A087WUL8
PRLSRELLDEKEPEV	NBPF20	321	P0DPF2
PRLSRELLDEKEPEV	NBPF20	1541	P0DPF2
PRLSRELLDEKEPEV	NBPF20	2761	P0DPF2
PRLSRELLDEKEPEV	NBPF20	3981	P0DPF2
LDLDRELEPEMEPKA	SLC26A8	876	Q96RN1
DRRETEKPDIDLEDP	NEXMIF	216	Q5QGS0
PEELEQEHLDLDPKR	FAM178B	151	Q8IXR5
TEEKERPEREPKLDL	SH3KBP1	376	Q96B97
PERELDLPVDLDDIS	SCG2	381	P13521
DKEEEEEENPLLVPL	FTSJ3	501	Q8IY81
ETEPVRALLPDEKKE	FAM13C	481	Q8NE31
SEESLEEEPRKVLAP	SPDYE2B	151	A6NHP3
PPLVIKEDELRESIE	OAT	416	P04181
EEPSLEPENEKILDI	SAFB	206	Q15424
LEQLREKLESAEPPE	ARID3A	446	Q99856
ENLLDILTEPERKPD	CKAP2L	186	Q8IYA6
TDILKAPPEDDNREI	CNOT1	431	A5YKK6
IELTEDGKPLEVPER	SLC17A6	41	Q9P2U8
LEIKIESAEEPPARE	TRPM6	1996	Q9BX84
RTEEEPLEEPLDEAL	UBA7	331	P41226
SEESLEEEPRKVLAP	SPDYE16	111	A6NNV3
SEESLEEEPRKVLAP	SPDYE18	151	P0DV79
SEESLEEEPRKVLAP	SPDYE21	151	A0A494C086
SEESLEEEPRKVLAP	SPDYE2	151	Q495Y8
EEELELERAPEPEDT	SPDYE4	66	A6NLX3
SEESLEEEPRKVLAP	SPDYE5	151	A6NIY4
SEESLEEEPRKVLAP	SPDYE6	151	P0CI01
ENPATEERPEKILAE	STX18	196	Q9P2W9
EERPEKILAETQPEL	STX18	201	Q9P2W9
SEESEEEPRKVLAPE	SPDYE1	111	Q8NFV5
DAEELPPILVDLLEK	SUPT20H	116	Q8NEM7
PLTKLEELPEDDANL	TMEM79	106	Q9BSE2
EELPEDDANLLPEKA	TMEM79	111	Q9BSE2
ADDEEEALEIPRPLR	ROBO2	1221	Q9HCK4
PLVPETEDDRKLAAL	YJU2B	216	P13994
KREIPAEEQITLEPE	TMOD4	101	Q9NZQ9
PPTEEEEGERALREK	ZC3H4	921	Q9UPT8
SEESLEEEPRKVLAP	nan	111	A6NJR5
PEDNKPLLEELDIDL	YIPF4	71	Q9BSR8
KPDVITLLDEERKEP	ZFP14	51	Q9HCL3
LSISELEEPLEPKRE	XKR5	621	Q6UX68
VIDIKPEPDDLIDED	ZC3H14	171	Q6PJT7
TEKVEPEEDRELAPT	ZMYND15	136	Q9H091
EDIKPLKRPRDEDDA	TOP1	131	P11387
RPKPTLEKDLEEDRE	ZSCAN5C	216	A6NGD5
LLADDKDEEDSPRPR	ZBTB46	561	Q86UZ6
LLSPEDEEELTAPEK	LAMC3	531	Q9Y6N6
EELTIILPEDIELKP	NAF1	186	Q96HR8