Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNHD1 MYH1 MYH4 MYH7 MYH8 DYNC1H1	4.26e-06	118	72	6	GO:0003774
GeneOntologyMolecularFunction	microfilament motor activity	MYH1 MYH4 MYH7 MYH8	1.05e-05	38	72	4	GO:0000146
GeneOntologyMolecularFunction	protein kinase inhibitor activity	TRIB3 PPP1R1B WNK1 HEXIM1	2.10e-04	81	72	4	GO:0004860
GeneOntologyMolecularFunction	kinase inhibitor activity	TRIB3 PPP1R1B WNK1 HEXIM1	2.64e-04	86	72	4	GO:0019210
GeneOntologyMolecularFunction	protein serine/threonine kinase inhibitor activity	PPP1R1B WNK1 HEXIM1	4.34e-04	41	72	3	GO:0030291
GeneOntologyMolecularFunction	phosphatase regulator activity	PPP1R1B PPP1R2C ANP32E ZEB2	7.44e-04	113	72	4	GO:0019208
GeneOntologyMolecularFunction	phosphatase inhibitor activity	PPP1R1B PPP1R2C ANP32E	9.77e-04	54	72	3	GO:0019212
GeneOntologyBiologicalProcess	muscle filament sliding	MYH4 MYH7 MYH8	1.65e-05	15	70	3	GO:0030049
GeneOntologyBiologicalProcess	actin-myosin filament sliding	MYH4 MYH7 MYH8	2.95e-05	18	70	3	GO:0033275
GeneOntologyBiologicalProcess	retrograde axonal transport	DST MAP1A DYNC1H1	7.20e-05	24	70	3	GO:0008090
GeneOntologyCellularComponent	muscle myosin complex	MYH1 MYH4 MYH7 MYH8	2.16e-07	16	71	4	GO:0005859
GeneOntologyCellularComponent	myosin filament	MYH1 MYH4 MYH7 MYH8	1.46e-06	25	71	4	GO:0032982
GeneOntologyCellularComponent	myosin II complex	MYH1 MYH4 MYH7 MYH8	2.35e-06	28	71	4	GO:0016460
GeneOntologyCellularComponent	myosin complex	MYH1 MYH4 MYH7 MYH8	4.83e-05	59	71	4	GO:0016459
Domain	Myosin_N	MYH1 MYH4 MYH7 MYH8	2.84e-07	15	73	4	PF02736
Domain	Myosin_N	MYH1 MYH4 MYH7 MYH8	2.84e-07	15	73	4	IPR004009
Domain	Myosin_tail_1	MYH1 MYH4 MYH7 MYH8	6.30e-07	18	73	4	PF01576
Domain	Myosin_tail	MYH1 MYH4 MYH7 MYH8	6.30e-07	18	73	4	IPR002928
Domain	Myosin-like_IQ_dom	MYH1 MYH4 MYH7 MYH8	7.96e-07	19	73	4	IPR027401
Domain	-	MYH1 MYH4 MYH7 MYH8	7.96e-07	19	73	4	4.10.270.10
Domain	Myosin_head_motor_dom	MYH1 MYH4 MYH7 MYH8	1.43e-05	38	73	4	IPR001609
Domain	MYOSIN_MOTOR	MYH1 MYH4 MYH7 MYH8	1.43e-05	38	73	4	PS51456
Domain	Myosin_head	MYH1 MYH4 MYH7 MYH8	1.43e-05	38	73	4	PF00063
Domain	MYSc	MYH1 MYH4 MYH7 MYH8	1.43e-05	38	73	4	SM00242
Domain	IQ_motif_EF-hand-BS	MYH1 MYH4 IQSEC3 MYH7 MYH8	2.69e-05	90	73	5	IPR000048
Domain	IQ	MYH1 MYH4 IQSEC3 MYH7 MYH8	3.16e-05	93	73	5	PS50096
Domain	TMEM132	TMEM132C TMEM132D	1.50e-04	5	73	2	PF16070
Domain	TMEM132D_N	TMEM132C TMEM132D	1.50e-04	5	73	2	PF15705
Domain	TMEM132D_C	TMEM132C TMEM132D	1.50e-04	5	73	2	PF15706
Domain	TMEM132_M	TMEM132C TMEM132D	1.50e-04	5	73	2	IPR031437
Domain	TMEM132_C	TMEM132C TMEM132D	1.50e-04	5	73	2	IPR031436
Domain	TMEM132_N	TMEM132C TMEM132D	1.50e-04	5	73	2	IPR031435
Domain	TMEM132	TMEM132C TMEM132D	1.50e-04	5	73	2	IPR026307
Domain	IQ	MYH1 MYH4 IQSEC3 MYH8	1.71e-04	71	73	4	PF00612
Domain	IQ	MYH1 MYH4 MYH7 MYH8	2.85e-04	81	73	4	SM00015
Domain	Dynein_HC_stalk	DNHD1 DYNC1H1	1.33e-03	14	73	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DYNC1H1	1.33e-03	14	73	2	IPR013602
Domain	DHC_N2	DNHD1 DYNC1H1	1.33e-03	14	73	2	PF08393
Domain	MT	DNHD1 DYNC1H1	1.33e-03	14	73	2	PF12777
Domain	DHC_fam	DNHD1 DYNC1H1	1.53e-03	15	73	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DYNC1H1	1.53e-03	15	73	2	IPR004273
Domain	Dynein_heavy	DNHD1 DYNC1H1	1.53e-03	15	73	2	PF03028
Domain	P-loop_NTPase	DNHD1 MYH1 MYH4 MYH7 MYH8 DHX38 DYNC1H1 DHX30 CHST3 RAB33B	1.64e-03	848	73	10	IPR027417
Domain	DUF1605	DHX38 DHX30	1.97e-03	17	73	2	IPR011709
Domain	OB_NTP_bind	DHX38 DHX30	1.97e-03	17	73	2	PF07717
Domain	HA2	DHX38 DHX30	2.21e-03	18	73	2	SM00847
Domain	HA2	DHX38 DHX30	2.21e-03	18	73	2	PF04408
Domain	Helicase-assoc_dom	DHX38 DHX30	2.21e-03	18	73	2	IPR007502
Domain	S_TKc	TAOK2 TRIB3 IRAK1 WNK1 EIF2AK3 SBK2	2.79e-03	359	73	6	SM00220
Domain	Pkinase	TAOK2 TRIB3 IRAK1 WNK1 EIF2AK3 SBK2	3.74e-03	381	73	6	PF00069
Domain	Kinase-like_dom	TAOK2 DST TRIB3 IRAK1 WNK1 EIF2AK3 SBK2	5.20e-03	542	73	7	IPR011009
Domain	ZnF_U1	ZFR2 ZNF830	5.71e-03	29	73	2	SM00451
Domain	Znf_U1	ZFR2 ZNF830	5.71e-03	29	73	2	IPR003604
Pubmed	Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development.	MYH1 MYH4 MYH7 MYH8	8.91e-11	5	73	4	12919077
Pubmed	Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.	MYH1 MYH4 MYH7 MYH8	2.67e-10	6	73	4	1728586
Pubmed	Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.	MYH1 MYH4 MYH7 MYH8	2.67e-10	6	73	4	10588881
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH1 MYH4 MYH7 MYH8	6.22e-10	7	73	4	35210422
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH1 MYH4 MYH7 MYH8	6.22e-10	7	73	4	16819597
Pubmed	Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.	MYH1 MYH4 MYH7 MYH8	1.24e-09	8	73	4	3864153
Pubmed	GASP-2 overexpressing mice exhibit a hypermuscular phenotype with contrasting molecular effects compared to GASP-1 transgenics.	GPRASP1 MYH1 MYH4 MYH7	2.23e-09	9	73	4	31960486
Pubmed	Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.	MYH1 MYH4 MYH7 MYH8	1.26e-08	13	73	4	8404542
Pubmed	Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.	MYH1 MYH4 MYH7 MYH8	1.76e-08	14	73	4	27184118
Pubmed	Three linked myosin heavy chain genes clustered within 370 kb of each other show independent transcriptional and post-transcriptional regulation during differentiation of a mouse muscle cell line.	MYH1 MYH4 MYH8	3.54e-08	4	73	3	1985022
Pubmed	Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.	MYH1 MYH4 MYH8	8.84e-08	5	73	3	6196357
Pubmed	Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.	MYH1 MYH4 MYH8	8.84e-08	5	73	3	3829126
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH1 MYH4 MYH8	1.77e-07	6	73	3	10077619
Pubmed	ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.	MYH1 MYH4 MYH7	3.09e-07	7	73	3	29758057
Pubmed	Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.	MYH1 MYH4 MYH7	4.93e-07	8	73	3	26993635
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	TAOK2 SETD1A DHX38 INTS1 ZC3H18 EIF3C GREB1 XAB2	6.08e-07	341	73	8	32971831
Pubmed	Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.	MYH1 MYH4 MYH7 MYH8	6.98e-07	33	73	4	32094117
Pubmed	The expression of myosin genes in developing skeletal muscle in the mouse embryo.	MYH4 MYH7 MYH8	1.05e-06	10	73	3	2211821
Pubmed	During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.	MYH1 MYH4 MYH8	1.05e-06	10	73	3	19506036
Pubmed	Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.	MYH1 MYH4 MYH7	1.45e-06	11	73	3	18310078
Pubmed	The histone code reader Spin1 controls skeletal muscle development.	MYH1 MYH4 MYH7	1.45e-06	11	73	3	29168801
Pubmed	Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity.	MYH1 MYH4 MYH8	1.45e-06	11	73	3	8136524
Pubmed	Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.	MYH1 MYH4 MYH7	1.45e-06	11	73	3	16024798
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TAOK2 TRIM33 CRACD DST SUPT6H RBM19 PIEZO1 DHX38 INTS1 LRCH4 EIF3C XAB2 HEXIM1 DHX30	2.41e-06	1497	73	14	31527615
Pubmed	HOXA5 plays tissue-specific roles in the developing respiratory system.	MYH1 MYH4 MYH7 MYH8	2.73e-06	46	73	4	28827394
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TAOK2 SETD1A DST TRIB3 RBM19 PIEZO1 INTS1 IRAK1 WNK1 DYNC1H1 ANO8 DHX30	3.07e-06	1105	73	12	35748872
Pubmed	Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy.	MYH1 MYH4 MYH7	3.18e-06	14	73	3	24938781
Pubmed	Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation.	MYH1 MYH4 MYH7	3.18e-06	14	73	3	33742095
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	CRACD MYH8 TRIB3 CETN1 DHX38 INTS1 ZC3H18 MEIS3 PAGR1 WNK1 XAB2 HEXIM1 DHX30	3.51e-06	1327	73	13	32694731
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ZNF512B CRACD DST MAP1A DHX38 IRAK1 ANP32E EIF3C WNK1 XAB2 DHX30	3.85e-06	934	73	11	33916271
Pubmed	Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.	MYH1 MYH4 MYH7	3.96e-06	15	73	3	24852826
Pubmed	Length-dependent effects on cardiac contractile dynamics are different in cardiac muscle containing α- or β-myosin heavy chain.	MYH4 MYH7	4.35e-06	2	73	2	23111184
Pubmed	Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells.	PIEZO1 PKD2	4.35e-06	2	73	2	24157948
Pubmed	Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome.	MYH4 MYH8	4.35e-06	2	73	2	8518795
Pubmed	Growth and muscle defects in mice lacking adult myosin heavy chain genes.	MYH1 MYH4	4.35e-06	2	73	2	9382868
Pubmed	Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains.	MYH1 MYH4	4.35e-06	2	73	2	11150240
Pubmed	Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1.	MYH1 MYH7	4.35e-06	2	73	2	35759444
Pubmed	Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle.	MYH1 MYH7	4.35e-06	2	73	2	2421254
Pubmed	PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization.	TAOK2 WNK1	4.35e-06	2	73	2	10660600
Pubmed	Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice.	MYH1 MYH4	4.35e-06	2	73	2	11744674
Pubmed	A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.	MYH1 MYH4 MYH7	4.87e-06	16	73	3	19922871
Pubmed	Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H.	MYH4 MYH7 MYH8	5.91e-06	17	73	3	16124007
Pubmed	IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.	MYH1 MYH4 MYH7	5.91e-06	17	73	3	22351927
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	TRIM33 LIG1 SUPT6H RBM19 DHX38 ANP32E EIF3C NSMCE2 XAB2 HEXIM1 DHX30	6.62e-06	989	73	11	36424410
Pubmed	Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.	MYH1 MYH4 MYH7 MYH8	6.95e-06	58	73	4	21884692
Pubmed	Human transcription factor protein interaction networks.	ZNF512B TRIM33 SETD1A PCGF6 DST IRAK1 ZC3H18 PAGR1 EIF3C ZEB2 DYNC1H1 DHX30 RAVER1	7.81e-06	1429	73	13	35140242
Pubmed	Transition of myosin heavy chain isoforms in human laryngeal abductors following denervation.	MYH1 MYH4	1.30e-05	3	73	2	26059207
Pubmed	Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.	MYH1 MYH4	1.30e-05	3	73	2	36515178
Pubmed	Structural and developmental analysis of two linked myosin heavy chain genes.	MYH1 MYH7	1.30e-05	3	73	2	1371481
Pubmed	The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation.	SETD1A SUPT6H	1.30e-05	3	73	2	22843687
Pubmed	The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway.	TRIB3 ARID5A	1.30e-05	3	73	2	34389433
Pubmed	Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha.	PKD2 EIF2AK3	1.30e-05	3	73	2	18664456
Pubmed	PKD2 deficiency suppresses amino acid biosynthesis in ADPKD by impairing the PERK-TBL2-eIF2ɑ-ATF4 pathway.	PKD2 EIF2AK3	1.30e-05	3	73	2	34015761
Pubmed	Identification of three developmentally controlled isoforms of human myosin heavy chains.	MYH7 MYH8	1.30e-05	3	73	2	1691980
Pubmed	The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.	MYH1 MYH7	1.30e-05	3	73	2	21470888
Pubmed	Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution.	MYH4 MYH7 MYH8	1.33e-05	22	73	3	37468485
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	MYH1 MYH4 MYH8	1.33e-05	22	73	3	24301466
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF512B TRIM33 GPRASP1 DST PSMG1 APBA2 EIF3C ZEB2 DYNC1H1 GOLGA3 XAB2 DHX30	1.41e-05	1285	73	12	35914814
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TAOK2 ZNF512B TRIM33 SETD1A DST SUPT6H PIEZO1 TMX4	1.54e-05	529	73	8	14621295
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	TRIM33 LIG1 MAP1A PSMG1 DHX38 ANP32E EIF3C DYNC1H1 DHX30	1.66e-05	704	73	9	29955894
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	ZNF512B TRIM33 PAGR1 XAB2 HEXIM1 RAVER1	2.19e-05	268	73	6	33640491
Pubmed	SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing.	MYH1 MYH4 MYH7	2.23e-05	26	73	3	26586428
Pubmed	Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.	TMC2 PIEZO1	2.60e-05	4	73	2	27893727
Pubmed	Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.	MYH1 MYH4	2.60e-05	4	73	2	10388558
Pubmed	Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity.	PRMT6 GREB1	2.60e-05	4	73	2	31930333
Pubmed	Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.	MYH1 MYH8	2.60e-05	4	73	2	20357587
Pubmed	A human YAC transgene rescues craniofacial and neural tube development in PDGFRalpha knockout mice and uncovers a role for PDGFRalpha in prenatal lung growth.	MYH1 MYH4	2.60e-05	4	73	2	11023856
Pubmed	Multiple quantitative trait loci modify cochlear hair cell degeneration in the Beethoven (Tmc1Bth) mouse model of progressive hearing loss DFNA36.	TMC2 MAP1A	2.60e-05	4	73	2	16648588
Pubmed	Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle.	MYH1 MYH4	2.60e-05	4	73	2	11029314
Pubmed	Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles.	MYH4 MYH7	2.60e-05	4	73	2	19948655
Pubmed	Genetic polymorphisms in hMTH1, hOGG1 and hMYH and risk of chronic benzene poisoning in a Chinese occupational population.	MYH1 NUDT1	2.60e-05	4	73	2	18848840
Pubmed	Modulation of skeletal muscle fiber type by mitogen-activated protein kinase signaling.	MYH1 MYH4	2.60e-05	4	73	2	18417546
Pubmed	Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation.	MYH1 MYH4	2.60e-05	4	73	2	12547197
Pubmed	Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.	SUPT6H PKD2 EIF2AK3	2.80e-05	28	73	3	24462114
Pubmed	Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.	MYH4 MYH8 CDH15	2.80e-05	28	73	3	25179606
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TAOK2 VGF GPRASP1 IQSEC3 KCNA4 DST HECW1 ZEB2 DYNC1H1 GOLGA3	3.24e-05	963	73	10	28671696
Pubmed	Functional proteomics mapping of a human signaling pathway.	ZNF512B DST RBM19 EIF3C ZEB2 DYNC1H1 XAB2 DHX30	3.38e-05	591	73	8	15231748
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	SUPT6H RBM19 DHX38 ANP32E ZC3H18 EIF3C WNK1 DYNC1H1 XAB2 HEXIM1 DHX30 RAVER1	3.63e-05	1415	73	12	28515276
Pubmed	Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism.	MYH1 MYH4 MYH7	3.82e-05	31	73	3	30081710
Pubmed	Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.	MYH1 MYH4 MYH7	3.82e-05	31	73	3	21985497
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	ZNF512B SUPT6H RBM19 DHX38 ZC3H18 EIF3C XAB2 DHX30	3.99e-05	605	73	8	28977666
Pubmed	MYH, OGG1, MTH1, and APC alterations involved in the colorectal tumorigenesis of Korean patients with multiple adenomas.	MYH1 NUDT1	4.33e-05	5	73	2	17252231
Pubmed	Detection of Gene and Protein Expression in Mouse Embryos and Tissue Sections.	MYH1 MYH4	4.33e-05	5	73	2	30737693
Pubmed	Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A.	KCNA4 MAP1A	4.33e-05	5	73	2	9786987
Pubmed	TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules.	TMEM132C TMEM132D	4.33e-05	5	73	2	29088312
Pubmed	Sox6 is required for normal fiber type differentiation of fetal skeletal muscle in mice.	MYH1 MYH7	4.33e-05	5	73	2	17584907
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	PRMT6 TRIM33 SUPT6H PSMG1 DHX38 INTS1 ANP32E ZC3H18 XAB2 HEXIM1	5.00e-05	1014	73	10	32416067
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	TRIM33 LIG1 SETD1A SUPT6H INTS1 ZC3H18 ZEB2	5.87e-05	469	73	7	27634302
Pubmed	The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development.	MYH7 MYH8	6.48e-05	6	73	2	2045411
Pubmed	A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity.	MYH1 MYH4	6.48e-05	6	73	2	20417199
Pubmed	A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre.	MYH1 MYH4	6.48e-05	6	73	2	17559643
Pubmed	The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes.	ZNF830 XAB2	6.48e-05	6	73	2	25599396
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DST SUPT6H DHX38 INTS1 ZC3H18 DYNC1H1 XAB2 DHX30	6.80e-05	653	73	8	22586326
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SETD1A HECW1 WNK1 DYNC1H1	7.01e-05	104	73	4	9205841
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	IRAK1 ZNF830 EIF3C DYNC1H1 DHX30	7.02e-05	203	73	5	35012549
Pubmed	Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.	MYH1 MYH4 MYH8	7.68e-05	39	73	3	38690566
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	RBM19 ANP32E ZEB2 DHX30	8.41e-05	109	73	4	33554859
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	PCGF6 MYH7 MYH8 DST SUPT6H EIF3C WNK1	8.43e-05	497	73	7	23414517
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ZNF512B DST MAP1A SUPT6H INTS1 ZC3H18 EIF3C DYNC1H1 XAB2 DHX30	8.57e-05	1082	73	10	38697112
Pubmed	A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation.	MYH4 MYH8	9.06e-05	7	73	2	10075840
Interaction	AURKC interactions	TAOK2 MYH1 MYH4 MYH7 MYH8 DHX38	1.00e-08	43	73	6	int:AURKC
Interaction	ASAH2 interactions	MYH1 MYH4 MYH7	9.05e-07	6	73	3	int:ASAH2
Interaction	ACTN2 interactions	MYH1 MYH4 MYH7 MYH8 KCNA4 PKD2 RAVER1	2.85e-06	171	73	7	int:ACTN2
Interaction	PRKAG2 interactions	MYH1 MYH4 MYH7 MYH8 MAP1A	4.74e-06	68	73	5	int:PRKAG2
Interaction	RSPH6A interactions	MYH1 MYH4 MYH7 MYH8	6.77e-06	34	73	4	int:RSPH6A
Interaction	ZSCAN5A interactions	MYH1 MYH4 MYH7 MYH8	1.07e-05	38	73	4	int:ZSCAN5A
Interaction	TMEM260 interactions	MYH1 MYH4 MYH7	1.27e-05	13	73	3	int:TMEM260
Interaction	FKBP6 interactions	VGF MYH1 MYH4 MYH7 MYH8	1.50e-05	86	73	5	int:FKBP6
Interaction	TERF2IP interactions	ZNF512B ERICH1 TRIM33 SETD1A SUPT6H DHX38 INTS1 ZNF830 ZC3H18 XAB2	2.89e-05	552	73	10	int:TERF2IP
Interaction	TWIST1 interactions	TRIB3 CETN1 RBM19 ANP32E ZEB2 DHX30	3.52e-05	170	73	6	int:TWIST1
Interaction	PARP1 interactions	ZNF512B TRIM33 LIG1 SETD1A TRIB3 NUDT1 CETN1 SUPT6H RBM19 INTS1 ANP32E ZC3H18 EIF3C HEXIM1 RAB33B	6.19e-05	1316	73	15	int:PARP1
Interaction	TSPAN33 interactions	MYH1 MYH4 MYH7 MYH8	9.08e-05	65	73	4	int:TSPAN33
Interaction	SLC39A3 interactions	MYH1 MYH4 MYH7 MYH8	1.21e-04	70	73	4	int:SLC39A3
Interaction	CCDC71 interactions	ZNF512B MAP1A SUPT6H HEXIM1	1.35e-04	72	73	4	int:CCDC71
Interaction	AKR7L interactions	DST MAP1A DHX38 HEXIM1	1.35e-04	72	73	4	int:AKR7L
Cytoband	16p11.2	TAOK2 SETD1A PAGR1 EIF3C	2.52e-04	191	73	4	16p11.2
Cytoband	17p13.1	MYH1 MYH4 MYH8	9.03e-04	118	73	3	17p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr16p11	TAOK2 SETD1A PAGR1 EIF3C	1.03e-03	278	73	4	chr16p11
Cytoband	Ensembl 112 genes in cytogenetic band chr16q24	PIEZO1 ZC3H18 CDH15	1.36e-03	136	73	3	chr16q24
GeneFamily	Myosin heavy chains	MYH1 MYH4 MYH7 MYH8	8.11e-08	15	52	4	1098
GeneFamily	DEAH-box helicases	DHX38 DHX30	9.49e-04	16	52	2	500
GeneFamily	EF-hand domain containing\|Nucleotide excision repair\|Transcription and export complex 2	LIG1 XAB2	1.21e-03	18	52	2	1269
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	TMEM132C TMEM132D PPP1R1B WNK1	1.81e-03	181	52	4	694
Coexpression	GSE29618_PRE_VS_DAY7_POST_LAIV_FLU_VACCINE_MDC_DN	MYH1 MYH4 TMX4 PKD2 APBA2 IRAK1 HEXIM1	1.26e-06	196	73	7	M5008
Coexpression	HUMMERICH_BENIGN_SKIN_TUMOR_DN	MYH1 MYH4 MYH8	2.28e-05	20	73	3	M1123
Coexpression	HUMMERICH_BENIGN_SKIN_TUMOR_DN	MYH1 MYH4 MYH8	2.66e-05	21	73	3	MM1102
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Etv1_\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	VGF TMEM132C MYH1 MYH4 MYH8	4.51e-06	148	73	5	4d43efee96a6493abd78e9ca41aab73db0c80626
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYH1 MYH4 MYH8 KCNA4 TMEM132D	9.92e-06	174	73	5	3503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCell	AT1-AT2_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	CRACD TMEM132D LRCH4 GJD4 CHST3	1.17e-05	180	73	5	3c7b2033821f9e34e2924bd8655f566edcbcc7d3
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-8\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	MYH1 MYH8 MAP1A ZEB2 CDH15	1.68e-05	194	73	5	55b97095a7a17a312c616703d291738a0f806339
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Etv1_\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TMEM132C MYH1 MYH4 MYH8	1.97e-05	97	73	4	f3c3fb260954f594a9ab8e1ac9a01115767cbc7a
Computational	Genes in the cancer module 453.	GPRASP1 INTS1 ANP32E RAVER1	2.94e-05	44	44	4	MODULE_453
Drug	purealin	MYH1 MYH4 MYH7 MYH8 DYNC1H1	1.10e-06	58	72	5	CID006419303
Drug	8-oxyguanine	LIG1 SETD1A MYH1 NUDT1 TMEM132D DYNC1H1	3.54e-06	130	72	6	CID000119315
Drug	AC1L1IZ2	LIG1 MYH1 MYH4 MYH7 MYH8 RBM19 WNK1 DYNC1H1	5.26e-06	304	72	8	CID000004795
Drug	fast white	MYH1 MYH4 MYH7 MYH8	9.39e-06	42	72	4	CID000024008
Drug	formycin triphosphate	MYH1 MYH4 MYH7 MYH8	2.05e-05	51	72	4	CID000122274
Drug	AC1LA61L	TAOK2 TMEM132D	2.95e-05	3	72	2	CID000482116
Drug	Scopoletin [92-61-5]; Up 200; 20.8uM; MCF7; HT_HG-U133A	TAOK2 HECW1 APOL6 APBA2 WNK1 SLC2A11	3.47e-05	194	72	6	6510_UP
Drug	B0683	MYH1 MYH4 MYH7 MYH8 PKD2	3.50e-05	117	72	5	CID006398969
Drug	4-epidoxorubicin	TAOK2 MYH1 CSRNP1 MYH4 MYH7 MYH8 HECW1 TMEM132D PPP1R1B ANP32E PAGR1	3.51e-05	788	72	11	CID000001690
Drug	Guanabenz acetate [23256-50-0]; Up 200; 13.8uM; PC3; HG-U133A	TRIM33 LIG1 NUDT1 PIEZO1 DYNC1H1 CHST3	3.67e-05	196	72	6	1961_UP
Drug	Piperine [94-62-2]; Up 200; 14uM; MCF7; HT_HG-U133A	MYH7 HECW1 APOL6 GREB1 WNK1 ARID5A	3.89e-05	198	72	6	4830_UP
Drug	Diprophylline [479-18-5]; Up 200; 15.8uM; MCF7; HT_HG-U133A	TRIM33 GPRASP1 APBA2 WNK1 SLC2A11 HEXIM1	3.89e-05	198	72	6	1689_UP
Drug	oxovanadium	MYH1 MYH4 MYH7 MYH8 DYNC1H1	3.95e-05	120	72	5	CID000024411
Drug	4-chloroaniline	MYH1 MYH4 MYH7 MYH8 RBM19 GREB1	4.35e-05	202	72	6	CID000007812
Drug	TBZ1	LIG1 PAGR1 DYNC1H1	6.63e-05	25	72	3	CID000122665
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	6.39e-09	10	71	4	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	6.39e-09	10	71	4	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	6.39e-09	10	71	4	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	6.39e-09	10	71	4	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	6.39e-09	10	71	4	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	6.39e-09	10	71	4	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	6.39e-09	10	71	4	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	6.39e-09	10	71	4	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	1.50e-08	12	71	4	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	1.50e-08	12	71	4	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	2.16e-08	13	71	4	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	4.12e-08	15	71	4	DOID:0050646 (implicated_via_orthology)
Disease	myopathy (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	5.53e-06	48	71	4	DOID:423 (implicated_via_orthology)
Disease	cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	2.65e-05	71	71	4	DOID:0050700 (implicated_via_orthology)
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH7 MYH8	4.24e-05	80	71	4	DOID:12930 (implicated_via_orthology)
Disease	schizophrenia (implicated_via_orthology)	SETD1A PPP1R1B CHST3	5.98e-04	68	71	3	DOID:5419 (implicated_via_orthology)
Disease	Papillary thyroid carcinoma	TRIM33 ZEB2 DYNC1H1	1.18e-03	86	71	3	C0238463
Disease	S-6-hydroxywarfarin measurement	PRMT6 CRACD HECW1 FERD3L CHST3	1.95e-03	368	71	5	EFO_0803326
Disease	platelet crit	CSRNP1 KCNA4 MAP1A PIEZO1 ZC3H18 NSMCE2 CDH15 RAVER1	2.01e-03	952	71	8	EFO_0007985

Protein segments in the cluster

Peptide	Gene	Start	Entry
DTIEEDLTRAGEEDG	ERICH1	276	Q86X53
GGEREEEQEREEEQA	ARID5A	46	Q03989
EGETIEDGARRELQE	NUDT1	41	P36639
DVLEDEEDIVEAARG	EIF2AK3	366	Q9NZJ5
ERESEAGVGLQRDED	APOL6	6	Q9BWW8
RLRRGDGDLEDQEED	APBA2	211	Q99767
EEEEEEEGGLRGEKR	ANP32E	241	Q9BTT0
EEERVPEVESEGELA	DNHD1	2701	Q96M86
LSRSLGREEEEDEEE	DHX30	181	Q7L2E3
GAPEEEEEAALVERR	ANO8	551	Q9HCE9
VEAGDAAERRAPEEE	RAVER1	21	Q8IY67
GRILGENEEEEDLAE	RBM19	386	Q9Y4C8
IGVDFRERAVEIDGE	RAB33B	66	Q9H082
AEDEGEGGREETERE	PAGR1	46	Q9BTK6
RELEEISERLEEAGG	MYH7	1141	P12883
VRLRGAVIGIDDEDD	OSBPL9	51	Q96SU4
VPGEDEERGTVEEQR	LRCH4	361	O75427
GLSGERAVEEEEEET	MAP1A	931	P78559
LEGGSRVDNEEEEEE	GREB1	51	Q4ZG55
RVDNEEEEEEGEGGL	GREB1	56	Q4ZG55
DDRTDRGLDEEGEEE	INTS1	2011	Q8N201
EEDLAVAVAGGRLEE	CSRNP1	181	Q96S65
EGEVLVEGLVEEENR	DST	2846	Q03001
RAGREEEEKEQEEEG	HECW1	496	Q76N89
VRDVEGEDSVRGVEG	PPP1R2C	86	O14990
AEGRRTDEEGGREEE	GJD4	246	Q96KN9
GGDDARVRELELELD	HEXIM1	316	O94992
ARIEELGEEIEAERA	MYH8	1116	P13535
READGTEGVDEDIIV	NSMCE2	146	Q96MF7
IDLVIEDRDGGCRED	MEIS3	171	Q99687
ELEEISERLEEAGGA	MYH1	1146	P12882
DLVEEEAEEAGVALR	IRAK1	436	P51617
ELDRGARRLEEGTEE	GOLGA3	791	Q08378
EEEETAEVGRGAEAE	IQSEC3	576	Q9UPP2
AGTEDEEEEEEGRRE	PSMG1	16	O95456
EEEEDNEGGEWERVR	EIF3C	291	Q99613
GELREDGREQEIRDG	WDPCP	721	O95876
GVTTNRREDEEEDEG	CD101	1006	Q93033
SGDLAGELEELEEER	SLC2A11	236	Q9BYW1
EEEEEERGRGVSLLG	FERD3L	76	Q96RJ6
LEETGEGRRGAEEED	CRACD	386	Q6ZU35
EGRRGAEEEDLGEEE	CRACD	391	Q6ZU35
TEEEDGAEREAALER	PRMT6	21	Q96LA8
EERGEAVDEGEIAEN	DYNC1H1	2116	Q14204
ARVLGSEGEEEDEAL	LIG1	61	P18858
QREGEAEAVGAVEEE	SBK2	331	P0C263
EAVSGVDVGRLEVED	CDH15	271	P55291
LRLEGGRQDSEDEEE	PCGF6	106	Q9BYE7
REESRPEAEEGDIIG	GPRASP1	766	Q5JY77
ELGREEEDDVDLELR	XAB2	316	Q9HCS7
VLVEEEEEEGGRAGA	TRIM33	41	Q9UPN9
AREEEEAEQERRGGE	VGF	361	O15240
EAEQERRGGEERVGE	VGF	366	O15240
RRGGEERVGEEDEEA	VGF	371	O15240
ESEDEDEEERRGRGC	TMEM132C	556	Q8N3T6
EEEEDDERRGRGCTL	TMEM132D	556	Q14C87
EEEEAVGERRILGKE	TAOK2	791	Q9UL54
ELEEISERLEEAGGA	MYH4	1146	Q9Y623
RGRLTEEEEAEPGTE	SETD1A	1236	O15047
RDGDGEVNEEEFLRI	CETN1	151	Q12798
DDEGQDGLREEEVQR	CHST3	326	Q7LGC8
RVREEGDEEGEGDEA	SUPT6H	491	Q7KZ85
GVTREEVEPEEAEEG	TMX4	306	Q9H1E5
DTLAEEDRGRREEEG	ZFR2	626	Q9UPR6
GLDEAREEEGDREVV	TRIB3	341	Q96RU7
EEESTRGEGEREKEE	USP35	696	Q9P2H5
RREEGEEGISFDTEE	DHX38	296	Q92620
DGVAEDERLGRDSEI	PKD2	886	Q13563
EASEGGEQEERERLR	ZNF512B	571	Q96KM6
EEEEEGDGERKRGDA	ZNF830	166	Q96NB3
DEEGRLDRQIGEIDE	ZNF830	296	Q96NB3
EEEEEEDSRDEGLGV	PIEZO1	751	Q92508
EETGVRVELAEEDDG	WNK1	481	Q9H4A3
EELGEQERGEAERTC	TMC2	81	Q8TDI7
REEEEDEIREGGVEH	ZEB2	81	O60315
ASEEEDELGELRELG	PPP1R1B	101	Q9UD71
GDEGEEDRTSDLRDE	ZC3H18	101	Q86VM9
EDEGFVREEEDRALP	KCNA4	271	P22459