Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR2 ITPR3	3.99e-07	3	148	3	GO:0005220
GeneOntologyMolecularFunction	structural constituent of postsynaptic actin cytoskeleton	POTEF POTEE POTEI	6.30e-05	11	148	3	GO:0098973
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	ITPR1 ITPR2 ITPR3	1.37e-04	14	148	3	GO:0070679
GeneOntologyMolecularFunction	alanine-glyoxylate transaminase activity	MGAT4A AGXT	1.63e-04	3	148	2	GO:0008453
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	ITPR1 ITPR2 ITPR3	3.00e-04	18	148	3	GO:0015278
GeneOntologyMolecularFunction	beta-adrenergic receptor kinase activity	GRK2 GRK3	3.24e-04	4	148	2	GO:0047696
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	FLT4 ACVR1 TEK TIE1 EPHA1	4.26e-04	85	148	5	GO:0019199
GeneOntologyMolecularFunction	protein kinase activity	FLT4 DAPK1 ALPK1 ACVR1 TEK MAST2 TTK GRK2 GRK3 TIE1 CSNK2A2 NRK EPHA1	5.37e-04	600	148	13	GO:0004672
GeneOntologyCellularComponent	platelet dense tubular network membrane	ITPR1 ITPR2 ITPR3	2.66e-05	9	145	3	GO:0031095
GeneOntologyCellularComponent	platelet dense tubular network	ITPR1 ITPR2 ITPR3	5.18e-05	11	145	3	GO:0031094
Domain	-	PIK3AP1 ANKRD31 POTEF POTEG DAPK1 YTHDC2 ANKRD6 POTEE TRANK1 ANKRD13C POTEM CASKIN1 KANK4 POTEI POTEH	1.52e-09	248	150	15	1.25.40.20
Domain	Ankyrin_rpt-contain_dom	PIK3AP1 ANKRD31 POTEF POTEG DAPK1 YTHDC2 ANKRD6 POTEE TRANK1 ANKRD13C POTEM CASKIN1 KANK4 POTEI POTEH	2.11e-09	254	150	15	IPR020683
Domain	ANK	ANKRD31 POTEF POTEG DAPK1 YTHDC2 ANKRD6 POTEE TRANK1 ANKRD13C POTEM CASKIN1 KANK4 POTEI POTEH	1.54e-08	251	150	14	SM00248
Domain	ANK_REPEAT	ANKRD31 POTEF POTEG DAPK1 YTHDC2 ANKRD6 POTEE TRANK1 ANKRD13C POTEM CASKIN1 KANK4 POTEI POTEH	1.70e-08	253	150	14	PS50088
Domain	ANK_REP_REGION	ANKRD31 POTEF POTEG DAPK1 YTHDC2 ANKRD6 POTEE TRANK1 ANKRD13C POTEM CASKIN1 KANK4 POTEI POTEH	1.79e-08	254	150	14	PS50297
Domain	Ankyrin_rpt	ANKRD31 POTEF POTEG DAPK1 YTHDC2 ANKRD6 POTEE TRANK1 ANKRD13C POTEM CASKIN1 KANK4 POTEI POTEH	2.65e-08	262	150	14	IPR002110
Domain	ARM-type_fold	IPO5 USP34 USP24 NBEA HSPBP1 ITPR1 ITPR2 HEATR6 LTN1 NOC4L RIC8A MMS19 TAF2 AP4B1 SYMPK	9.98e-08	339	150	15	IPR016024
Domain	Ank	ANKRD31 POTEF POTEG DAPK1 ANKRD6 POTEE ANKRD13C POTEM CASKIN1 KANK4 POTEI POTEH	3.21e-07	228	150	12	PF00023
Domain	InsP3_rcpt-bd	ITPR1 ITPR2 ITPR3	5.08e-07	3	150	3	IPR000493
Domain	Ank_2	ANKRD31 POTEF POTEG DAPK1 ANKRD6 POTEE ANKRD13C POTEM CASKIN1 POTEI POTEH	1.34e-06	215	150	11	PF12796
Domain	LRR	LRTM1 TLR6 OMD STK11IP SLITRK2 PXDN LRRC27 LRRC56 CD180 LRRC15	5.28e-06	201	150	10	PS51450
Domain	RIH_assoc-dom	ITPR1 ITPR2 ITPR3	9.98e-06	6	150	3	IPR013662
Domain	Ins145_P3_rec	ITPR1 ITPR2 ITPR3	9.98e-06	6	150	3	PF08709
Domain	RIH_assoc	ITPR1 ITPR2 ITPR3	9.98e-06	6	150	3	PF08454
Domain	RIH_dom	ITPR1 ITPR2 ITPR3	9.98e-06	6	150	3	IPR000699
Domain	Ins145_P3_rcpt	ITPR1 ITPR2 ITPR3	9.98e-06	6	150	3	IPR014821
Domain	Ryanodine_recept-rel	ITPR1 ITPR2 ITPR3	9.98e-06	6	150	3	IPR015925
Domain	-	ITPR1 ITPR2 ITPR3	9.98e-06	6	150	3	1.25.10.30
Domain	RYDR_ITPR	ITPR1 ITPR2 ITPR3	9.98e-06	6	150	3	PF01365
Domain	LRR_8	LRTM1 TLR6 OMD SLITRK2 PXDN LRRC27 LRRC28 CD180 LRRC15	1.01e-05	171	150	9	PF13855
Domain	LRR_1	LRTM1 TLR6 OMD SLITRK2 PXDN LRRC27 LRRC56 LRRC28 CD180 LRRC15	1.12e-05	219	150	10	PF00560
Domain	Leu-rich_rpt	LRTM1 TLR6 OMD STK11IP SLITRK2 PXDN LRRC27 LRRC56 LRRC28 CD180 LRRC15	1.23e-05	271	150	11	IPR001611
Domain	LRR_TYP	LRTM1 TLR6 OMD SLITRK2 PXDN LRRC27 LRRC28 CD180 LRRC15	1.33e-05	177	150	9	SM00369
Domain	Leu-rich_rpt_typical-subtyp	LRTM1 TLR6 OMD SLITRK2 PXDN LRRC27 LRRC28 CD180 LRRC15	1.33e-05	177	150	9	IPR003591
Domain	-	LRTM1 TLR6 OMD STK11IP SLITRK2 PXDN LRRC27 LRRC56 LRRC28 CD180 LRRC15	5.81e-05	321	150	11	3.80.10.10
Domain	MIR	ITPR1 ITPR2 ITPR3	5.85e-05	10	150	3	PF02815
Domain	MIR_motif	ITPR1 ITPR2 ITPR3	5.85e-05	10	150	3	IPR016093
Domain	MIR	ITPR1 ITPR2 ITPR3	5.85e-05	10	150	3	PS50919
Domain	MIR	ITPR1 ITPR2 ITPR3	5.85e-05	10	150	3	SM00472
Domain	ARM-like	IPO5 NBEA HSPBP1 HEATR6 LTN1 NOC4L RIC8A MMS19 AP4B1 SYMPK	6.69e-05	270	150	10	IPR011989
Domain	L_dom-like	LRTM1 TLR6 OMD STK11IP SLITRK2 PXDN LRRC27 LRRC56 LRRC28 CD180 LRRC15	7.05e-05	328	150	11	IPR032675
Domain	Cys-rich_flank_reg_C	LRTM1 TLR6 SLITRK2 PXDN CD180 LRRC15	8.68e-05	90	150	6	IPR000483
Domain	LRRCT	LRTM1 TLR6 SLITRK2 PXDN CD180 LRRC15	8.68e-05	90	150	6	SM00082
Domain	Kinase-like_dom	FLT4 WDR81 DAPK1 ALPK1 ACVR1 TEK MAST2 TTK GRK2 GRK3 TIE1 CSNK2A2 NRK EPHA1	1.23e-04	542	150	14	IPR011009
Domain	Protein_kinase_ATP_BS	FLT4 DAPK1 ACVR1 TEK TTK GRK2 GRK3 TIE1 CSNK2A2 NRK EPHA1	2.50e-04	379	150	11	IPR017441
Domain	Actin_CS	POTEF POTEE POTEI	2.63e-04	16	150	3	IPR004001
Domain	ACTINS_2	POTEF POTEE POTEI	3.18e-04	17	150	3	PS00432
Domain	PROTEIN_KINASE_ATP	FLT4 DAPK1 ACVR1 TEK MAST2 TTK GRK2 GRK3 TIE1 CSNK2A2 NRK EPHA1	3.40e-04	459	150	12	PS00107
Domain	Actin/actin-like_CS	POTEF POTEE POTEI	3.79e-04	18	150	3	IPR020902
Domain	ACTINS_ACT_LIKE	POTEF POTEE POTEI	4.48e-04	19	150	3	PS01132
Domain	Prot_kinase_dom	FLT4 DAPK1 ACVR1 TEK MAST2 TTK GRK2 GRK3 TIE1 CSNK2A2 NRK EPHA1	5.97e-04	489	150	12	IPR000719
Domain	PROTEIN_KINASE_DOM	FLT4 DAPK1 ACVR1 TEK MAST2 TTK GRK2 GRK3 TIE1 CSNK2A2 NRK EPHA1	6.41e-04	493	150	12	PS50011
Domain	KRAB	ZNF132 ZNF585A ZNF613 ZNF689 ZNF19 ZNF28 ZNF860 ZNF468 ZNF160 ZNF304	6.44e-04	358	150	10	PS50805
Domain	KRAB	ZNF132 ZNF585A ZNF613 ZNF689 ZNF19 ZNF28 ZNF860 ZNF468 ZNF160 ZNF304	6.44e-04	358	150	10	PF01352
Domain	KRAB	ZNF132 ZNF585A ZNF613 ZNF689 ZNF19 ZNF28 ZNF860 ZNF468 ZNF160 ZNF304	8.12e-04	369	150	10	SM00349
Domain	KRAB	ZNF132 ZNF585A ZNF613 ZNF689 ZNF19 ZNF28 ZNF860 ZNF468 ZNF160 ZNF304	8.29e-04	370	150	10	IPR001909
Domain	-	ZNF132 HIVEP1 ZNF585A ZNF613 ZNF689 INSM1 ZNF629 ZNF19 ZNF28 ZFHX2 ZNF860 ZNF468 ZNF160 ZNF304	1.16e-03	679	150	14	3.30.160.60
Domain	LRRNT	LRTM1 OMD SLITRK2 PXDN LRRC15	1.17e-03	98	150	5	IPR000372
Domain	LRRNT	LRTM1 OMD SLITRK2 PXDN LRRC15	1.17e-03	98	150	5	SM00013
Domain	Munc13_1	UNC13D CADPS	1.31e-03	7	150	2	IPR014770
Domain	MHD1	UNC13D CADPS	1.31e-03	7	150	2	PS51258
Domain	DUF1041	UNC13D CADPS	1.31e-03	7	150	2	PF06292
Domain	GPCR_kinase	GRK2 GRK3	1.31e-03	7	150	2	IPR000239
Domain	CAPS_dom	UNC13D CADPS	1.31e-03	7	150	2	IPR010439
Domain	zf-C2H2	ZNF132 HIVEP1 ZNF585A ZNF613 ZNF689 INSM1 ZNF629 ZNF19 ZNF28 ZFHX2 ZNF860 ZNF468 ZNF160 ZNF304	1.41e-03	693	150	14	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF132 HIVEP1 ZNF585A ZNF613 ZNF689 INSM1 ZNF629 ZNF19 ZNF28 ZFHX2 ZNF860 ZNF468 ZNF160 ZNF304	1.43e-03	694	150	14	IPR013087
Domain	Actin	POTEF POTEE POTEI	1.94e-03	31	150	3	IPR004000
Domain	Actin	POTEF POTEE POTEI	1.94e-03	31	150	3	PF00022
Domain	ACTIN	POTEF POTEE POTEI	1.94e-03	31	150	3	SM00268
Domain	PID	APBB1 CCM2 TBC1D1	2.12e-03	32	150	3	PS01179
Domain	-	IPO5 HSPBP1 HEATR6 RIC8A MMS19 AP4B1 SYMPK	2.14e-03	222	150	7	1.25.10.10
Domain	BEACH	WDR81 NBEA	2.22e-03	9	150	2	PS50197
Domain	Beach	WDR81 NBEA	2.22e-03	9	150	2	PF02138
Domain	-	WDR81 NBEA	2.22e-03	9	150	2	1.10.1540.10
Domain	Beach	WDR81 NBEA	2.22e-03	9	150	2	SM01026
Domain	BEACH_dom	WDR81 NBEA	2.22e-03	9	150	2	IPR000409
Domain	S_TKc	DAPK1 ACVR1 TEK MAST2 TTK GRK2 GRK3 CSNK2A2 NRK	2.50e-03	359	150	9	SM00220
Domain	ZINC_FINGER_C2H2_2	ZNF132 HIVEP1 ZNF585A ZNF613 ZNF689 INSM1 ZNF629 ZNF19 ZNF28 ZFHX2 ZNF860 ZNF468 ZNF160 ZNF304	3.90e-03	775	150	14	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF132 HIVEP1 ZNF585A ZNF613 ZNF689 INSM1 ZNF629 ZNF19 ZNF28 ZFHX2 ZNF860 ZNF468 ZNF160 ZNF304	3.99e-03	777	150	14	PS00028
Domain	PTB/PI_dom	APBB1 CCM2 TBC1D1	4.33e-03	41	150	3	IPR006020
Domain	Znf_C2H2-like	ZNF132 HIVEP1 ZNF585A ZNF613 ZNF689 INSM1 ZNF629 ZNF19 ZNF28 ZFHX2 ZNF860 ZNF468 ZNF160 ZNF304	4.93e-03	796	150	14	IPR015880
Domain	Znf_C2H2	ZNF132 HIVEP1 ZNF585A ZNF613 ZNF689 INSM1 ZNF629 ZNF19 ZNF28 ZFHX2 ZNF860 ZNF468 ZNF160 ZNF304	5.43e-03	805	150	14	IPR007087
Domain	Tyr_kinase_cat_dom	FLT4 TEK TIE1 EPHA1	5.53e-03	88	150	4	IPR020635
Domain	TyrKc	FLT4 TEK TIE1 EPHA1	5.53e-03	88	150	4	SM00219
Domain	ZnF_C2H2	ZNF132 HIVEP1 ZNF585A ZNF613 ZNF689 INSM1 ZNF629 ZNF19 ZNF28 ZFHX2 ZNF860 ZNF468 ZNF160 ZNF304	5.60e-03	808	150	14	SM00355
Domain	HEAT	IPO5 MMS19 SYMPK	6.74e-03	48	150	3	PF02985
Domain	PROTEIN_KINASE_TYR	FLT4 TEK TIE1 EPHA1	7.78e-03	97	150	4	PS00109
Domain	Tyr_kinase_AS	FLT4 TEK TIE1 EPHA1	7.78e-03	97	150	4	IPR008266
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	NBEA ADCY5 ITPR1 ITPR2 ITPR3 GRK2	6.02e-07	41	107	6	M512
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	NBEA ADCY5 ITPR1 ITPR2 ITPR3 GRK2	3.19e-06	54	107	6	M26911
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	4.21e-06	5	107	3	M49000
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	8.36e-06	6	107	3	M47960
Pathway	KEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	3.45e-05	9	107	3	M47852
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	4.91e-05	10	107	3	M47661
Pathway	REACTOME_OPIOID_SIGNALLING	NBEA ADCY5 ITPR1 ITPR2 ITPR3 GRK2	6.17e-05	90	107	6	M6467
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	6.71e-05	11	107	3	M49033
Pathway	REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION	ITPR1 ITPR2 ITPR3	6.71e-05	11	107	3	M27466
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	1.15e-04	13	107	3	M47656
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	1.15e-04	13	107	3	M47696
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	1.15e-04	13	107	3	M47751
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2 ITPR3	1.15e-04	13	107	3	MM14553
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2 ITPR3	2.22e-04	16	107	3	M26945
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	ADCY5 ITPR1 ITPR2 ITPR3	2.81e-04	42	107	4	M791
Pathway	REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION	ITPR1 ITPR2 ITPR3	3.77e-04	19	107	3	M27423
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	3.77e-04	19	107	3	M47760
Pathway	KEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	3.77e-04	19	107	3	M47733
Pathway	KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	4.41e-04	20	107	3	M47688
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	5.12e-04	21	107	3	M47689
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	5.89e-04	22	107	3	M47690
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	5.89e-04	22	107	3	M47675
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	6.74e-04	23	107	3	M47676
Pathway	REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	PIK3AP1 ITPR1 ITPR2 ITPR3	6.90e-04	53	107	4	MM15716
Pathway	REACTOME_ION_HOMEOSTASIS	ABCC9 ITPR1 ITPR2 ITPR3	7.41e-04	54	107	4	M27460
Pathway	REACTOME_ION_HOMEOSTASIS	ABCC9 ITPR1 ITPR2 ITPR3	7.41e-04	54	107	4	MM15202
Pathway	KEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY	FLT4 ITPR1 ITPR2 ITPR3	7.95e-04	55	107	4	M47952
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	ITPR1 ITPR2 ITPR3	8.66e-04	25	107	3	MM14511
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR1 ITPR2 ITPR3	1.09e-03	27	107	3	MM15053
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	ITPR1 ITPR2 ITPR3	1.09e-03	27	107	3	M12123
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	ADCY5 ITPR1 ITPR2 ITPR3	1.17e-03	61	107	4	MM15071
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR1 ITPR2 ITPR3	1.21e-03	28	107	3	M924
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	POTEF POTEG POTEE POTEM POTEI	4.19e-09	15	151	5	16824795
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	10874040
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	9808793
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	20395455
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	17437169
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	18194433
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	36350267
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	27777977
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	11413485
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	26009177
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	17581770
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	18241669
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	1693919
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	19068129
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	23955339
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	31979185
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	24904548
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	17327232
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	16014380
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	17890015
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	23983250
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	9858485
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR1 ITPR2 ITPR3	8.02e-08	3	151	3	20427533
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR1 ITPR2 ITPR3	3.20e-07	4	151	3	25215520
Pubmed	Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.	ITPR1 ITPR2 ITPR3	3.20e-07	4	151	3	21424589
Pubmed	Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.	ITPR1 ITPR2 ITPR3	3.20e-07	4	151	3	28615414
Pubmed	Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.	ITPR1 ITPR2 ITPR3	3.20e-07	4	151	3	10828023
Pubmed	Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.	ITPR1 ITPR3 CSNK2A2	3.20e-07	4	151	3	14685260
Pubmed	IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.	ITPR1 ITPR2 ITPR3	3.20e-07	4	151	3	28419336
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2 ITPR3	3.20e-07	4	151	3	11163362
Pubmed	IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.	ITPR1 ITPR2 ITPR3	3.20e-07	4	151	3	35494252
Pubmed	InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.	ITPR1 ITPR2 ITPR3	7.97e-07	5	151	3	21568942
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	ITPR1 ITPR2 ITPR3	1.59e-06	6	151	3	23463619
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	ITPR1 ITPR2 ITPR3	1.59e-06	6	151	3	21762810
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	ITPR1 ITPR2 ITPR3	1.59e-06	6	151	3	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	ITPR1 ITPR2 ITPR3	1.59e-06	6	151	3	25966694
Pubmed	Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.	POTEG POTEM POTEH	1.59e-06	6	151	3	17171436
Pubmed	Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium.	FLT4 TEK TIE1	1.59e-06	6	151	3	7596436
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	ITPR1 ITPR2 ITPR3	1.59e-06	6	151	3	16844763
Pubmed	Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.	POTEG POTEE POTEH	2.77e-06	7	151	3	15276201
Pubmed	Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1.	FLT4 TEK TIE1	2.77e-06	7	151	3	11566878
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	ITPR1 ITPR2 ITPR3	2.77e-06	7	151	3	11860456
Pubmed	Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.	ITPR1 ITPR2 ITPR3	2.77e-06	7	151	3	22495310
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP34 USP24 USP16 KIF7 MRPS7 TIMELESS UTRN	3.87e-06	147	151	7	29576527
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	IPO5 USP34 TBC1D15 EPM2A LEO1 YTHDC2 HSPBP1 FAAP100 LANCL2 KIF7 ITPR3 MRPS7 CSNK2A2 LTN1 TMEM131L UTRN	5.71e-06	974	151	16	28675297
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IPO5 USP34 USP24 YTHDC2 BIRC6 ITPR3 WDR3 IARS2 PHF3 CSNK2A2 NOC4L UTRN SYMPK	6.01e-06	653	151	13	22586326
Pubmed	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	FLT4 TEK TIE1 EPHA1	6.45e-06	28	151	4	18593464
Pubmed	Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.	POTEE POTEM POTEI	6.61e-06	9	151	3	16364570
Pubmed	Involvement of insulin-like growth factor 2 in angiogenic factor transcription in Bi-maternal mouse conceptuses.	FLT4 TEK TIE1	6.61e-06	9	151	3	19881219
Pubmed	Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.	ITPR1 ITPR2 ITPR3	6.61e-06	9	151	3	25737585
Pubmed	The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF.	FLT4 TEK TIE1	9.41e-06	10	151	3	10395786
Pubmed	Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development.	FLT4 TEK TIE1	9.41e-06	10	151	3	10323857
Pubmed	Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice.	FLT4 TEK TIE1	9.41e-06	10	151	3	7596435
Pubmed	Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.	ITPR1 ITPR2 ITPR3	1.29e-05	11	151	3	27514653
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CCDC14 STAM2 LEO1 KIAA1549 NBEA BIRC6 TAB3 KIF7 ITPR1 ITPR2 ITPR3 LTN1 NOC4L ELP2 UTRN SYMPK	1.43e-05	1049	151	16	27880917
Pubmed	Requirement of the MADS-box transcription factor MEF2C for vascular development.	FLT4 TEK TIE1	1.72e-05	12	151	3	9778514
Pubmed	Genetic and developmental bases of serial homology in vertebrate limb evolution.	TBX4 TBX5	1.87e-05	2	151	2	11076746
Pubmed	Tie-1: A potential target for anti-angiogenesis therapy.	TEK TIE1	1.87e-05	2	151	2	26489611
Pubmed	Cloning of GRK2 cDNA from S49 murine lymphoma cells.	GRK2 GRK3	1.87e-05	2	151	2	8638670
Pubmed	Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.	ITPR2 ITPR3	1.87e-05	2	151	2	9065779
Pubmed	Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.	ITPR2 ITPR3	1.87e-05	2	151	2	17496801
Pubmed	Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor.	ITPR1 ITPR3	1.87e-05	2	151	2	8663526
Pubmed	Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2.	TEK TIE1	1.87e-05	2	151	2	10995770
Pubmed	Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.	GRK2 GRK3	1.87e-05	2	151	2	33060647
Pubmed	Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.	TTK USP16	1.87e-05	2	151	2	28380042
Pubmed	The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.	ITPR1 ITPR3	1.87e-05	2	151	2	15890645
Pubmed	Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells.	TEK TIE1	1.87e-05	2	151	2	8395828
Pubmed	Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.	ITPR2 ITPR3	1.87e-05	2	151	2	24901844
Pubmed	Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.	ITPR2 ITPR3	1.87e-05	2	151	2	33854148
Pubmed	Tbx4/5 gene duplication and the origin of vertebrate paired appendages.	TBX4 TBX5	1.87e-05	2	151	2	19995988
Pubmed	G protein--coupled receptor kinases.	GRK2 GRK3	1.87e-05	2	151	2	8035170
Pubmed	Localization of the angiopoietin receptors Tie-1 and Tie-2 on the primary cilia in the female reproductive organs.	TEK TIE1	1.87e-05	2	151	2	15893943
Pubmed	Co-occurrence of mutations in KIF7 and KIAA0556 in Joubert syndrome with ocular coloboma, pituitary malformation and growth hormone deficiency: a case report and literature review.	KIF7 KATNIP	1.87e-05	2	151	2	32164589
Pubmed	An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.	ITPR1 ITPR2	1.87e-05	2	151	2	18708078
Pubmed	Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.	ITPR1 ITPR2	1.87e-05	2	151	2	15201137
Pubmed	Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.	ITPR2 ITPR3	1.87e-05	2	151	2	19528657
Pubmed	A primate-specific POTE-actin fusion protein plays a role in apoptosis.	POTEF POTEE	1.87e-05	2	151	2	19669888
Pubmed	Different regulation of T-box genes Tbx4 and Tbx5 during limb development and limb regeneration.	TBX4 TBX5	1.87e-05	2	151	2	12376111
Pubmed	Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.	ITPR2 ITPR3	1.87e-05	2	151	2	8063813
Pubmed	The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.	TEK TIE1	1.87e-05	2	151	2	8846781
Pubmed	Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	1.87e-05	2	151	2	8081734
Pubmed	Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.	ITPR1 ITPR2	1.87e-05	2	151	2	23582047
Pubmed	Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.	ITPR1 ITPR3	1.87e-05	2	151	2	1374893
Pubmed	A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.	TEK TIE1	1.87e-05	2	151	2	1312667
Pubmed	T-box genes and the formation of vertebrate forelimb- and hindlimb specific pattern.	TBX4 TBX5	1.87e-05	2	151	2	10199965
Pubmed	Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival.	TEK TIE1	1.87e-05	2	151	2	17504972
Pubmed	IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.	ITPR2 ITPR3	1.87e-05	2	151	2	16195467
Pubmed	Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.	GRK2 GRK3	1.87e-05	2	151	2	10198406
Pubmed	Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.	ITPR2 ITPR3	1.87e-05	2	151	2	15632133
Pubmed	Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis.	TEK TIE1	1.87e-05	2	151	2	14530387
Pubmed	Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands.	TEK TIE1	1.87e-05	2	151	2	20227369
Pubmed	Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.	ITPR1 ITPR3	1.87e-05	2	151	2	20813840
Pubmed	Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.	ITPR2 ITPR3	1.87e-05	2	151	2	15713744
Pubmed	G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.	GRK2 GRK3	1.87e-05	2	151	2	11762794
Pubmed	Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.	ITPR1 ITPR3	1.87e-05	2	151	2	7559486
Pubmed	Tie2 receptor expression and phosphorylation in cultured cells and mouse tissues.	TEK TIE1	1.87e-05	2	151	2	9108247
Pubmed	Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.	ITPR1 ITPR3	1.87e-05	2	151	2	20843799
Pubmed	Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.	ITPR1 ITPR2	1.87e-05	2	151	2	19120126
Pubmed	Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling.	ITPR1 ITPR3	1.87e-05	2	151	2	14707143
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEF POTEG POTEE POTEM POTEI POTEH	5.84e-11	13	106	6	685
GeneFamily	Ankyrin repeat domain containing	ANKRD31 POTEF POTEG DAPK1 ANKRD6 POTEE TRANK1 ANKRD13C POTEM CASKIN1 KANK4 POTEI POTEH	1.70e-09	242	106	13	403
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR2 ITPR3	1.96e-07	3	106	3	297
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF132 HIVEP1 ZNF585A ZNF613 ZNF689 ZNF629 ZNF19 ZNF28 ZFHX2 ZNF860 ZNF468 ZNF160 ZNF304	2.91e-04	718	106	13	28
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDR81 NBEA	1.19e-03	9	106	2	1230
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	FLT4 TEK TIE1	1.65e-03	40	106	3	321
GeneFamily	Fibronectin type III domain containing	MYOM1 TEK GHR TIE1 EPHA1	2.52e-03	160	106	5	555
GeneFamily	Ubiquitin specific peptidases	USP34 USP24 USP16	4.33e-03	56	106	3	366
GeneFamily	T-boxes	TBX4 TBX5	4.90e-03	18	106	2	766
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	ABCC9 OMD ANKRD6 TEK ITPR2 GHR NRK UTRN	2.15e-07	184	150	8	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ABCC9 STK11IP FAAP100 SLC3A1 SERPINB10 TRIM56	2.75e-06	181	150	7	709e9c7a60d5f98635b99895ce30bb87a9f7376d
ToppCell	droplet-Kidney-nan-3m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 TTC21A TEK PXDN TIE1 KANK4 LRRC15	2.85e-06	182	150	7	f4a5f1c3a04c0566eb96607dab7a0d9a5ebc3fd1
ToppCell	Sepsis-ICU-SEP-Lymphocyte-T/NK-Treg\|ICU-SEP / Disease, condition lineage and cell class	ANKRD31 GALM HLF MCMDC2 CCM2 LRRC56 NAIF1	4.81e-06	197	150	7	c3ee2d522fbfe67069ddba2d1abfc4f5ca230c26
ToppCell	ICU-SEP-Lymphocyte-T_NK-Treg\|ICU-SEP / Disease, Lineage and Cell Type	ANKRD31 GALM HLF MCMDC2 CCM2 LRRC56	9.86e-06	145	150	6	ee99b58462f955b96d036aa67e343db047d66f64
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A1BG LRTM1 KIF7 NDST3 CD180 TBX5	1.11e-05	148	150	6	dfd3f2c4b884ea9e23831a242a89ac985b409640
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-9\|TCGA-Breast / Sample_Type by Project: Shred V9	POTEF POTEE POTEM POTEI POTEH	1.35e-05	90	150	5	96e836c7a1df279ac812b7c3aa75e6b81b614244
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF585A TTC21A ZNF629 ACVR1 CXCR5 ZNF860	1.50e-05	156	150	6	7ece590fd8f29382e349dd0e5e016d2926aeb518
ToppCell	5'-Adult-LymphNode-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PIK3AP1 DLGAP2 E2F5 ZNF19 TMEM131L CD180	1.79e-05	161	150	6	d8140e7772b4e327dafa3536881a784d3c328d2a
ToppCell	droplet-Bladder-BLADDER-1m-Endothelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLF ABCC9 TEK TIE1 KANK4 NOL8	3.15e-05	178	150	6	6bef4ef48f649c6e38ae732bc08e6d7814db588b
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRTM1 STEAP4 ABCC9 NBEA STK11IP ITPR1	3.25e-05	179	150	6	dd94ebe69ade6f51b94058abe066216f0de9feda
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3AP1 DAPK1 ADCY5 BTBD16 PXDN NRK	3.56e-05	182	150	6	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYOM1 STEAP4 ABCC9 CADPS TMEM131L UTRN	3.90e-05	185	150	6	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TBX4 HLF GHR PXDN LRRC15 TBX5	3.90e-05	185	150	6	427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell	343B-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ZNF613 WDR81 YTHDC2 OMD ITPR3 ZNF28	3.90e-05	185	150	6	1b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCell	343B-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ZNF613 WDR81 YTHDC2 OMD ITPR3 ZNF28	3.90e-05	185	150	6	02cbf492bc40abebaa93a3a208888afae72fbe06
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYOM1 STEAP4 ABCC9 CADPS TMEM131L UTRN	3.90e-05	185	150	6	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	USP34 USP24 BIRC6 ITPR1 TMEM131L UTRN	4.27e-05	188	150	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	facs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX4 HLF LRTM1 ABCC9 LRRC15 TBX5	4.53e-05	190	150	6	c7bd087f36321cec61b98657433b4d19d135791f
ToppCell	facs-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX4 HLF LRTM1 ABCC9 LRRC15 TBX5	4.53e-05	190	150	6	834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCell	10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-naive_B_cell\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ITPR2 CXCR5 GRK3 ZNF860 CD180 UTRN	4.66e-05	191	150	6	a073d58154c801ec499fd969f42b7f1ee7f15d79
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TBX4 HLF GHR NDST3 CADPS TBX5	4.80e-05	192	150	6	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	droplet-Bladder-Unstain-18m-Endothelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 MYOM1 STEAP4 ABCC9 TIE1 AGXT	5.23e-05	195	150	6	fbfe4a8ae9775764108b45920eec92003b24fb2e
ToppCell	droplet-Bladder-Unstain-18m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 MYOM1 STEAP4 ABCC9 TIE1 AGXT	5.23e-05	195	150	6	2a6056172c41c46acfe0242be22269ef1d07921e
ToppCell	mild-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FLT4 HIVEP1 MANEA E2F5 ZNF860 SYMPK	5.23e-05	195	150	6	1e5f1967bcc898318f4e970b844b4a944eb168e5
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PIK3AP1 DAPK1 TLR6 ITPR2 GRK3 UTRN	5.53e-05	197	150	6	10190b877bf46ba2163d203df9dd3b498c66e52f
ToppCell	mild-dn_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CCDC14 MGAT4A USP24 TRANK1 PXDN TBC1D1	5.53e-05	197	150	6	07a1f59c83b748825e0708cd1cc7b63a2cb856cc
ToppCell	TCGA-Skin-Metastatic-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	PIK3AP1 USP34 MGAT4A ABCC9 ITPR1 CD180	5.69e-05	198	150	6	af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCell	TCGA-Skin-Metastatic\|TCGA-Skin / Sample_Type by Project: Shred V9	PIK3AP1 USP34 MGAT4A ABCC9 ITPR1 CD180	5.69e-05	198	150	6	ad39cce004867f083f8da1954e0cf5a263815184
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	PIK3AP1 USP34 MGAT4A ABCC9 ITPR1 CD180	5.69e-05	198	150	6	62cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	USP34 NBEA BIRC6 ITPR2 UTRN HERC4	5.85e-05	199	150	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBX4 MYOM1 ADCY5 PXDN TBC1D1 TBX5	5.85e-05	199	150	6	b1753474152b82a0b811b9878c890a359e14919a
ToppCell	TCGA-Brain-Primary_Tumor-Glioblastoma-Primary_GBM-11\|TCGA-Brain / Sample_Type by Project: Shred V9	POTEF POTEG POTEE POTEI	6.07e-05	63	150	4	d7dc1356a60cb527fe668328d5375f352239d911
Disease	Hypoxic Brain Damage	ITPR1 ITPR2	2.30e-05	2	142	2	C1140716
Disease	Anoxic Encephalopathy	ITPR1 ITPR2	2.30e-05	2	142	2	C0003132
Disease	Brain Hypoxia	ITPR1 ITPR2	2.30e-05	2	142	2	C1527348
Disease	Anoxia of brain	ITPR1 ITPR2	2.30e-05	2	142	2	C0995195
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR2 ITPR3	2.33e-05	12	142	3	DOID:1441 (implicated_via_orthology)
Disease	response to mepolizumab	EPM2A UTRN	2.28e-04	5	142	2	EFO_0008459
Disease	age of onset of multiple sclerosis	ITPR1 LRRC56	1.47e-03	12	142	2	OBA_2001029
Disease	peripheral arterial disease, traffic air pollution measurement	DLGAP2 NBEA ITPR2 SLC39A12 UTRN	2.53e-03	194	142	5	EFO_0004265, EFO_0007908
Disease	lateral occipital cortex volume measurement	EPM2A UTRN	2.98e-03	17	142	2	EFO_0010311
Disease	serum dimethylarginine measurement	MYOM1 MANEA TBC1D1	3.51e-03	63	142	3	EFO_0005418
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	TRIM56 ZNF160	4.55e-03	21	142	2	EFO_0004286, EFO_0004792

Protein segments in the cluster

Peptide	Gene	Start	Entry
PHFQKLQAHLEQLLA	EPHA1	871	P21709
HSLQIAHFDLKPENI	DAPK1	131	P53355
RDLKPANILLDEHGH	GRK3	316	P35626
TVPVFHLFHKLLAGQ	BIRC6	3961	Q9NR09
HLFHKLLAGQPLPAE	BIRC6	3966	Q9NR09
ALPEILFAKVSQGHH	CXCR5	181	P32302
LGGTQIHLHKIPQDL	BTBD16	241	Q32M84
LAHLHIEIFGTQGKP	ACVR1	316	Q04771
HLLLAHNAPVKVKNA	ANKRD13C	161	Q8N6S4
GGVVINKPIAHHLLN	AP4B1	191	Q9Y6B7
EKQLPLHRDGFHTLQ	DLGAP2	196	Q9P1A6
KNLHHNLLNKIILGP	ABCC9	1066	O60706
LPLHAAHNQLLNAKL	APBB1	26	O00213
FIDNAKRAHQLPGHL	CCM2	91	Q9BSQ5
HLHLDLLGAIVQAFP	DNHD1	121	Q96M86
GHHQDSKPSLLFLLE	DNHD1	2441	Q96M86
HNILPKDVAAHFLAR	ADCY5	1041	O95622
NQHLLAGLPVLRHLN	CD180	461	Q99467
AGLPVLRHLNLKGNH	CD180	466	Q99467
LSAELVQHFHKPALL	PIK3AP1	71	Q6ZUJ8
LLNIHDKQLQHDPAP	CCDC14	671	Q49A88
VHQPPAFLHKLLQLA	ATG2A	216	Q2TAZ0
PQINLSLLKEFDHHL	ALPK1	261	Q96QP1
LHLAANKGHLPVVQI	ANKRD6	46	Q9Y2G4
RDLKPANILLDEHGH	GRK2	316	P25098
HNVELSKLLHKLGQP	NDST3	846	O95803
LGHVLTLGKNPHLAL	CYP1A2	51	P05177
LHKHLNLFLTPGLLE	ITPR2	1256	Q14571
LHKHLHLFLTPGLLE	ITPR3	1246	Q14573
GQHNKDDILIIHEPA	KIAA1549	1361	Q9HCM3
LKDPGLQHGQLFNHL	LTN1	446	O94822
HLDSPAIKHQFLLTG	A1BG	71	P04217
GILPLHDAVANNHLK	ANKRD31	1221	Q8N7Z5
NGKFHKHLQDLFAPL	CADPS	966	Q9ULU8
HLPHLLKNEGSLQPA	MGAT4A	111	Q9UM21
HGLTPLLLGVHEQKQ	POTEF	271	A5A3E0
SPLHLAAKNGHIDII	CASKIN1	191	Q8WXD9
PQAVCLLHALLEKGH	EPM2A	246	O95278
KAPLQGDHNHLFIRQ	LEO1	461	Q8WVC0
PGAFHGLQHLQVLNL	LRTM1	91	Q9HBL6
AELGNHILHQPLKAA	MCMDC2	56	Q4G0Z9
GNPLHIAQKLFRDGH	NFRKB	101	Q6P4R8
GVHHLLNLTQPKLAQ	ERVS71-1	286	P61550
NQALLHKHINLFLNP	ITPR1	1261	Q14643
HKHINLFLNPGILEA	ITPR1	1266	Q14643
LAFHKGDIIHLQPLE	MYO15A	2886	Q9UKN7
LKKHLLVNHFNAGVP	NAIF1	26	Q69YI7
EPLLKQARHVHILGF	NLRP10	301	Q86W26
TFHNLGNVHSPLKLL	GPC3	551	P51654
DHHLVIPSVLQGLKA	MMS19	101	Q96T76
SNVLPLLLEQFHKHS	MMS19	391	Q96T76
KEGQALPIHLHQISA	KATNIP	1236	O60303
VLLLDNKPDHHFLEA	KCNT1	816	Q5JUK3
LPFHQDGKIIHNFIR	LANCL2	61	Q9NS86
NAARLLFHKLIQPDH	HERC4	461	Q5GLZ8
LFHKLIQPDHPQISQ	HERC4	466	Q5GLZ8
ALGNLLHFLQPSHIE	HEATR6	931	Q6AI08
LPKELLHGHQSCLQV	KIF7	26	Q2M1P5
LENPLKLPLHHEDAF	HLF	26	Q16534
KKLVHNALANLDGHP	NOL8	776	Q76FK4
LLAHFLAEHKAIPFQ	OR2F1	81	Q13607
LLAHFLAEHKAIPFQ	OR2F2	81	O95006
HNVALFKHFADLLPG	IPO5	206	O00410
GDPNALVKILHHLEE	FAAP100	266	Q0VG06
PELHQRTIHLGKNFD	MANEA	46	Q5SRI9
VRAAHGIPDLAQKLH	METTL27	16	Q8N6F8
HGLTPLLLGVHEQKQ	POTEE	271	Q6S8J3
FSLLHIQEGLNPGHL	PROX2	431	Q3B8N5
NLLPLFCHHVDKQLV	PATL2	516	C9JE40
KPVELGKHLQDFHLN	GALM	226	Q96C23
NLEDHTKLPLIFHLG	GALNS	431	P34059
SPAQLKLHKIFLHQD	CARD6	476	Q9BX69
NLKSHSGPIHVLLIN	E2F5	216	Q15329
EVHHGTKNLGPIQLF	GHR	71	P10912
LILHFNHPIKTENLA	C5orf58	41	C9J3I9
LDPHFNDILGQHSRK	CSNK2A2	266	P19784
LSGHVAQAFPTKLHL	MAST2	1366	Q6P0Q8
QPHSPHFLKLLVNLA	KANK4	806	Q5T7N3
ALHFLGLQPLHAAVE	SDR42E2	406	A6NKP2
QLLKAVHLQGHEGPV	ELP2	96	Q6IA86
RFLNLIHHAAQGPTK	FAM183BP	66	Q6ZVS7
HGVPLLKQLCDHILF	NBEAP1	31	P0C6P0
ALLHLIPQVLGLHKQ	SLC39A12	416	Q504Y0
GLEHKADLQQHLFPV	SLFN13	386	Q68D06
LLALNGLFILIHKHN	NOC4L	306	Q9BVI4
LLAHHQALQAKGAPL	INSM1	386	Q01101
VFAKLPNLLQLHLEH	OMD	136	Q99983
LQHLPPLAAVADKFH	ONECUT3	111	O60422
ILLHFPLVNASFKDH	PLA2G4D	726	Q86XP0
QVFLPLLSQDHHVLL	NRK	586	Q7Z2Y5
AFLLQNLLVGHPEHK	HSPBP1	251	Q9NZL4
FILGKEHQLKELHPL	RPUSD2	256	Q8IZ73
PQQKIDELHHGFTGL	MEIOC	216	A2RUB1
PTLQQLNHVFELHLG	STK11IP	36	Q8N1F8
DGLAFNAVLHRHKPD	UTRN	181	P46939
SHKLLEAFHNQGPVI	MRPS7	206	Q9Y2R9
EGLAQHKPVLLFLTH	AGXT	141	P21549
GIQFLGHPVAKILHA	TMEM131L	101	A2VDJ0
HIDPQHAAGKQLICL	TAB3	106	Q8N5C8
QKLKLTNNHLDPFGH	TBX5	156	Q99593
LKELQLHGNHLEYIP	LRRC15	151	Q8TF66
NLHHFPLELLKDEGL	LRRC28	26	Q86X40
GAHQHLKTLLLERNP	LRRC27	111	Q9C0I9
HLPNLDQLKLNGSHL	LRRC56	91	Q8IYG6
IHINFSLDQPKGGLH	TAF2	146	Q6P1X5
HGAPLLKQLCDHILF	NBEA	586	Q8NFP9
LRNNHFSHLPVKGVL	SLITRK2	501	Q9H156
HDKGLKLIIDFIPNH	SLC3A1	201	Q07837
ILQHKDELNADHPFI	SERPINB5	341	P36952
HGLTPLLLGVHEQKQ	POTEI	271	P0CG38
DPHVGHALNKILKDI	IARS2	121	Q9NSE4
QLLELPEQQEGHLKH	IVL	151	P07476
FHGHAVNLLGNLPLK	RIC8A	271	Q9NPQ8
LPILTQHHQDKPLFD	TIMELESS	66	Q9UNS1
PFLKDILHLAEHQGT	ZNF132	121	P52740
HSHLPELQLFQGEGK	ZNF160	186	Q9HCG1
HLSNLVLHGDIPQDF	USP16	771	Q9Y5T5
AFVGNSPLLRHQKIH	ZNF19	281	P17023
KPLEAQLLLNGFHHV	ZFHX2	656	Q9C0A1
LCKLGHHPNIINLLG	TIE1	891	P35590
AHGNPLLLDCKNVHL	FLT4	601	P35916
LGSHKPLILQHENLE	TBC1D1	1006	Q86TI0
ENFQPIAQDHLPLHK	PXDN	1086	Q92626
LPGLSHNKEHLTEQI	PHF3	1681	Q92576
LAHLVPGAHVVKAFN	STEAP4	121	Q687X5
HKVPHVALQALTLLG	STAM2	56	O75886
LCKLGHHPNIINLLG	TEK	876	Q02763
PALHFHQGDSKLLIE	TBC1D15	161	Q8TC07
HQVLEKAPDNFLVLH	TTC21A	981	Q8NDW8
ALLPQNHKLIHELAA	SYMPK	796	Q92797
LQILNAKTLHLVFHP	TLR6	191	Q9Y2C9
GLAFIQKAHLIAHQI	ZNF585A	416	Q6P3V2
KESLPFQFAHHLLNP	YTHDC2	1376	Q9H6S0
QHQLLHTGEKPFPCL	ZNF689	446	Q96CS4
PHELKNTFQLLHEIL	USP24	2446	Q9UPU5
HGIVHSDLKPANFLI	TTK	641	P33981
PLRQNHDTFDLHGKI	ZNF613	121	Q6PF04
IKDQLGLSFHSHLPE	ZNF28	136	P17035
PLLKDILHLAEHQGS	ZNF304	96	Q9HCX3
IKDQLGLSFHSHLPE	ZNF860	151	A6NHJ4
LKLTNNHLDPFGHII	TBX4	171	P57082
QHGLHSNIPCLSKLL	ZMYM1	1056	Q5SVZ6
EHIFGPNLHIEIIKQ	USP34	376	Q70CQ2
IHSPHGELKAVFLLQ	WDR3	371	Q9UNX4
PLHAALHIFLEIKAD	TRANK1	501	O15050
VLLQHQLTHGNEKPF	ZNF629	676	Q9UEG4
HGLTPLLLGVHEQKQ	POTEG	271	Q6S5H5
NKHGLTPLLLGVHEQ	POTEH	306	Q6S545
HGLTPLLLGVHEQKQ	POTEM	271	A6NI47
HSPLASQNGFLHLLL	UHRF1BP1	1271	Q6BDS2
IKDQLGSSFHLHLPE	ZNF468	136	Q5VIY5
PDRGQCHLQFQLIHK	UNC13D	271	Q70J99
HAHTIKLGLVLQPDA	HIVEP1	456	P15822
LHIFHIEKPKAVGLQ	SERPINB10	226	P48595
GLQAFLTHLLPHVLQ	WDR81	996	Q562E7
VKARLHHILQQDAPF	PPIP5K1	631	Q6PFW1
QLELHPGLLDKNCHL	TRIM56	351	Q9BRZ2
NPNGHHFLTKEELLQ	MUS81	151	Q96NY9
AKLNEDHLLHAPEFI	MYOM1	266	P52179