Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncyclic nucleotide-dependent protein kinase activity

PRKG2 PRKX PRKY

5.71e-069833GO:0004690
GeneOntologyMolecularFunctionkinase activity

TRPM6 TPK1 NEK5 LRRK2 INSRR HKDC1 PRKG2 FYN PRKX PRKY DCLK1

3.14e-047648311GO:0016301
GeneOntologyMolecularFunctioncAMP-dependent protein kinase activity

PRKX PRKY

3.54e-047832GO:0004691
GeneOntologyMolecularFunctionchromatin insulator sequence binding

ZFX ZFY

3.54e-047832GO:0043035
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

TRPM6 NEK5 LRRK2 INSRR HKDC1 PRKG2 FYN PRKX PRKY DCLK1

7.02e-047098310GO:0016773
GeneOntologyMolecularFunctionprotein serine kinase activity

TRPM6 NEK5 LRRK2 PRKG2 PRKX PRKY DCLK1

7.87e-04363837GO:0106310
GeneOntologyMolecularFunctionprotein kinase activity

TRPM6 NEK5 LRRK2 INSRR PRKG2 FYN PRKX PRKY DCLK1

8.55e-04600839GO:0004672
GeneOntologyBiologicalProcessnegative regulation of vacuolar transport

VPS35 LRRK2

1.60e-052832GO:1903336
GeneOntologyBiologicalProcessnegative regulation of late endosome to lysosome transport

VPS35 LRRK2

1.60e-052832GO:1902823
GeneOntologyBiologicalProcessprotein kinase A signaling

LRRK2 PRKG2 PRKX PRKY

4.14e-0548834GO:0010737
GeneOntologyBiologicalProcessregulation of dendritic spine maintenance

VPS35 ZMYND8 FYN

4.91e-0518833GO:1902950
GeneOntologyBiologicalProcessregulation of late endosome to lysosome transport

VPS35 LRRK2

9.55e-054832GO:1902822
GeneOntologyBiologicalProcessregulation of terminal button organization

SNAP91 VPS35

9.55e-054832GO:2000331
GeneOntologyBiologicalProcessregulation of postsynapse organization

SHANK2 VPS35 ZMYND8 LRRK2 FYN DCLK1

1.02e-04185836GO:0099175
GeneOntologyBiologicalProcesspositive regulation of dopamine receptor signaling pathway

VPS35 LRRK2

1.59e-045832GO:0060161
GeneOntologyBiologicalProcessregulation of vacuolar transport

VPS35 LRRK2

1.59e-045832GO:1903335
GeneOntologyBiologicalProcessdendritic spine maintenance

VPS35 ZMYND8 FYN

2.36e-0430833GO:0097062
DomainZfx_Zfy_act

ZFX ZFY

5.98e-053842PF04704
DomainTranscrp_activ_Zfx/Zfy-dom

ZFX ZFY

5.98e-053842IPR006794
DomainZINC_FINGER_C2H2_2

ZNF729 ZNF280A ZNF512B GFI1B TANK ZNF846 ZNF485 ZNF75A ZNF317 PRDM15 ZFX ZFY

1.74e-047758412PS50157
DomainZINC_FINGER_C2H2_1

ZNF729 ZNF280A ZNF512B GFI1B TANK ZNF846 ZNF485 ZNF75A ZNF317 PRDM15 ZFX ZFY

1.78e-047778412PS00028
DomainZnf_C2H2

ZNF729 ZNF280A ZNF512B GFI1B TANK ZNF846 ZNF485 ZNF75A ZNF317 PRDM15 ZFX ZFY

2.47e-048058412IPR007087
DomainSer-Thr/Tyr_kinase_cat_dom

NEK5 INSRR FYN PRKX PRKY

3.96e-04138845IPR001245
DomainKinase-like_dom

TRPM6 NEK5 LRRK2 INSRR PRKG2 FYN PRKX PRKY DCLK1

7.28e-04542849IPR011009
DomainZnf_C2H2-like

ZNF729 ZNF280A ZNF512B GFI1B ZNF846 ZNF485 ZNF75A ZNF317 PRDM15 ZFX ZFY

8.55e-047968411IPR015880
Domain-

ZNF729 ZNF280A GFI1B ZNF846 ZNF485 ZNF75A ZNF317 PRDM15 ZFX ZFY

9.22e-0467984103.30.160.60
DomainZnF_C2H2

ZNF729 ZNF280A ZNF512B GFI1B ZNF846 ZNF485 ZNF75A ZNF317 PRDM15 ZFX ZFY

9.65e-048088411SM00355
DomainPROTEIN_KINASE_ATP

NEK5 LRRK2 INSRR PRKG2 FYN PRKX PRKY DCLK1

1.07e-03459848PS00107
DomainZnf_C2H2/integrase_DNA-bd

ZNF729 ZNF280A GFI1B ZNF846 ZNF485 ZNF75A ZNF317 PRDM15 ZFX ZFY

1.09e-036948410IPR013087
DomainProtein_kinase_ATP_BS

NEK5 LRRK2 INSRR PRKG2 FYN PRKX DCLK1

1.59e-03379847IPR017441
DomainProt_kinase_dom

NEK5 LRRK2 INSRR PRKG2 FYN PRKX PRKY DCLK1

1.59e-03489848IPR000719
DomainPROTEIN_KINASE_DOM

NEK5 LRRK2 INSRR PRKG2 FYN PRKX PRKY DCLK1

1.68e-03493848PS50011
DomainZinc_finger_PHD-type_CS

ZMYND8 NSD1 KDM5D

3.14e-0365843IPR019786
DomainPWWP

ZMYND8 NSD1

3.60e-0320842SM00293
Domainzf-C2H2

ZNF729 GFI1B ZNF846 ZNF485 ZNF75A ZNF317 PRDM15 ZFX ZFY

3.90e-03693849PF00096
DomainFCH

ARHGAP4 GAS7

4.36e-0322842PF00611
DomainFCH

ARHGAP4 GAS7

4.36e-0322842SM00055
DomainPHD

ZMYND8 NSD1 KDM5D

4.69e-0375843PF00628
DomainPWWP

ZMYND8 NSD1

4.76e-0323842PF00855
DomainPWWP_dom

ZMYND8 NSD1

4.76e-0323842IPR000313
DomainFCH_dom

ARHGAP4 GAS7

4.76e-0323842IPR001060
DomainPWWP

ZMYND8 NSD1

5.17e-0324842PS50812
DomainZnf_PHD-finger

ZMYND8 NSD1 KDM5D

5.43e-0379843IPR019787
DomainSer/Thr_kinase_AS

NEK5 LRRK2 PRKG2 PRKX PRKY DCLK1

5.44e-03357846IPR008271
DomainS_TKc

NEK5 LRRK2 PRKG2 PRKX PRKY DCLK1

5.59e-03359846SM00220
DomainF_BAR

ARHGAP4 GAS7

5.61e-0325842IPR031160
DomainF_BAR

ARHGAP4 GAS7

5.61e-0325842PS51741
DomainPROTEIN_KINASE_ST

NEK5 LRRK2 PRKG2 PRKX PRKY DCLK1

5.82e-03362846PS00108
Pubmed

Maintenance of X inactivation of the Rps4, Zfx, and Ube1 genes in a mouse in vitro system.

RPS4Y2 ZFX ZFY

1.51e-0758737681608
Pubmed

An evaluation of the inactive mouse X chromosome in somatic cell hybrids.

RPS4Y2 ZFX ZFY

5.25e-0778738460399
Pubmed

Embryonic growth and the evolution of the mammalian Y chromosome. II. Suppression of selfish Y-linked growth factors may explain escape from X-inactivation and rapid evolution of Sry.

RPS4Y2 ZFX ZFY

5.25e-0778737928394
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

SRRM1 EEF1G AFF2 LRRK2 CDK5RAP2 SPEN DOP1A

9.64e-0720887733230847
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

EEF1G MDN1 NUP107 ORC3 ZMYND8 TPX2 MORC3 DDX39A

1.92e-0633287832786267
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

SRRM1 EEF1G MDN1 VPS35 TPX2 NSD1 GNL3

2.11e-0623487736243803
Pubmed

Rps4 maps near the inactivation center on the mouse X chromosome.

RPS4Y2 ZFX ZFY

4.25e-06138731740345
Pubmed

XIST and the mapping of the X chromosome inactivation centre.

RPS4Y2 ZFX ZFY

4.25e-06138731772416
Pubmed

The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.

PRKX PRKY

6.19e-0628727633447
Pubmed

Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.

VPS35 LRRK2

6.19e-06287232631998
Pubmed

Zfa is an expressed retroposon derived from an alternative transcript of the Zfx gene.

ZFX ZFY

6.19e-0628721691708
Pubmed

The structure of the Zfx gene on the mouse X chromosome.

ZFX ZFY

6.19e-0628728188262
Pubmed

Mapping the human ZFX locus to Xp21.3 by in situ hybridization.

ZFX ZFY

6.19e-0628722497060
Pubmed

Man to mouse--lessons learned from the distal end of the human X chromosome.

PRKX PRKY

6.19e-0628729414316
Pubmed

Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.

ZFX ZFY

6.19e-0628722041734
Pubmed

Gene expression, X-inactivation, and methylation during spermatogenesis: the case of Zfa, Zfx, and Zfy in mice.

ZFX ZFY

6.19e-0628728318216
Pubmed

Profiles of PrKX expression in developmental mouse embryo and human tissues.

PRKX PRKY

6.19e-06287215879576
Pubmed

Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers.

ZFX ZFY

6.19e-0628722105457
Pubmed

[Expression of Zfx in mouse testicular spermatogenic cells].

ZFX ZFY

6.19e-06287238602753
Pubmed

VPS35 and retromer dysfunction in Parkinson's disease.

VPS35 LRRK2

6.19e-06287238368930
Pubmed

Differential rates of evolution for the ZFY-related zinc finger genes, Zfy, Zfx, and Zfa in the mouse genus Mus.

ZFX ZFY

6.19e-06287212716983
Pubmed

Intron/exon structure confirms that mouse Zfy1 and Zfy2 are members of the ZFY gene family.

ZFX ZFY

6.19e-0628729126493
Pubmed

Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes.

ZFX ZFY

6.19e-06287219329779
Pubmed

Chromosomal localization of ZFX--a human gene that escapes X inactivation--and its murine homologs.

ZFX ZFY

6.19e-0628721970799
Pubmed

Evolution of the Zfx and Zfy genes: rates and interdependence between the genes.

ZFX ZFY

6.19e-0628728487630
Pubmed

PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.

PRKX PRKY

6.19e-06287221684272
Pubmed

Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.

PRKX PRKY

6.19e-0628729302280
Pubmed

Comparison of human ZFY and ZFX transcripts.

ZFX ZFY

6.19e-0628722308929
Pubmed

RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis.

ZFX ZFY

6.19e-06287228251288
Pubmed

Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.

ZFX ZFY

6.19e-06287234324278
Pubmed

What lysosomes actually tell us about Parkinson's disease?

VPS35 LRRK2

6.19e-06287226947123
Pubmed

Zfx mutation results in small animal size and reduced germ cell number in male and female mice.

ZFX ZFY

6.19e-0628729187153
Pubmed

A novel murine PKA-related protein kinase involved in neuronal differentiation.

PRKX PRKY

6.19e-06287210729225
Pubmed

Regional assignments of the zinc finger Y-linked gene (ZFY) and related sequences on human and mouse chromosomes.

ZFX ZFY

6.19e-0628722265557
Pubmed

Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.

KDM5D ZFX ZFY

6.73e-061587314762062
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

RPS4Y2 SRRM1 MDN1 SHANK2 SNAP91 SYNE2 VPS35 GARS1 HKDC1 ODF2 DDX39A SPEN TUBD1 DOP1A

1.33e-051442871435575683
Pubmed

Zfy gene expression patterns are not compatible with a primary role in mouse sex determination.

ZFX ZFY

1.85e-0538722480529
Pubmed

Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency.

PRKX PRKY

1.85e-05387217980165
Pubmed

Genetic dissection of mammalian fertility pathways.

ZFX ZFY

1.85e-05387212479614
Pubmed

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.

VPS35 LRRK2

1.85e-05387223395371
Pubmed

Identification of a mouse male-specific transplantation antigen, H-Y.

KDM5D ZFY

1.85e-0538727544442
Pubmed

FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13.

PRKX PRKY

1.85e-0538729154127
Pubmed

X chromosome genes and premature ovarian failure.

ZFX ZFY

1.85e-05387211299520
Pubmed

Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation.

VPS35 LRRK2

1.85e-05387238862989
Pubmed

Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.

ZFX ZFY

1.85e-05387232406922
Pubmed

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.

VPS35 LRRK2

1.85e-05387229743203
Pubmed

Isolation of monochromosomal hybrids for mouse chromosomes 3, 6, 10, 12, 14, and 18.

ZFX ZFY

1.85e-0538729060403
Pubmed

Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling.

ZFX ZFY

1.85e-05387238310188
Pubmed

Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity.

VPS35 LRRK2

1.85e-05387233135724
Pubmed

YAC clone contigs surrounding the Zfx and Pola loci on the mouse X chromosome.

ZFX ZFY

1.85e-0538728406471
Pubmed

Smcy transgene does not rescue spermatogenesis in sex-reversed mice.

KDM5D ZFY

1.85e-05387211210179
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZNF512B WDR3 SRRM1 MDN1 NUP107 ORC3 ZC3H8 ZMYND8 TPX2 NSD1 SPEN GNL3 ZFX

1.96e-051294871330804502
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF512B SRRM1 SMC6 TPX2 NSD1 MORC3 SPEN PRDM15 GNL3

2.20e-0560887936089195
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

WDR3 NUP107 SMC6 ZMYND8 TPX2 YY1AP1 SPEN

2.44e-0534187732971831
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

WDR3 SRRM1 EEF1G AFF2 NUP107 SMC6 LRRK2 ADAMTS16 CDK5RAP2 SPEN

2.48e-05777871035844135
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

ZNF512B WDR3 SRRM1 EEF1G SNAP91 SMC6 ZMYND8 TPX2 NSD1 SPEN GNL3

2.62e-05954871136373674
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

HAUS8 NAA15 NUP107 ORC3 GARS1 SMC6 TPX2 CDK5RAP2 MORC3 DDX39A FYN GNL3

3.04e-051155871220360068
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

ZNF512B SRRM1 HAUS8 SMC6 TPX2 MORC3 ODF2 SPEN PRDM15

3.48e-0564587925281560
Pubmed

Transposition of RhoA to the murine Y chromosome.

KDM5D ZFY

3.70e-0548729598304
Pubmed

ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.

ZFX ZFY

3.70e-05487224485662
Pubmed

Molecular analysis of an isoYq chromosome in a sterile male mouse.

KDM5D ZFY

3.70e-0548728678984
Pubmed

Zfx controls the self-renewal of embryonic and hematopoietic stem cells.

ZFX ZFY

3.70e-05487217448993
Pubmed

The human pituitary nitroproteome: detection of nitrotyrosyl-proteins with two-dimensional Western blotting, and amino acid sequence determination with mass spectrometry.

SNAP91 PRKG2

3.70e-05487215555551
Pubmed

Autosomal dominant Parkinson's disease: Incidence of mutations in LRRK2, SNCA, VPS35 and GBA genes in Brazil.

VPS35 LRRK2

3.70e-05487227777137
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

WDR3 SRRM1 NAA15 MDN1 NUP107 SYNE2 NSD1 SPEN GNL3

3.83e-0565387922586326
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

SRRM1 MDN1 ZMYND8 TPX2 NSD1 GNL3 ZFX ZFY

5.84e-0553387830554943
Pubmed

The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr).

ZFX ZFY

6.16e-0558729244432
Pubmed

Chromosome mapping and expression of a putative testis-determining gene in mouse.

ZFX ZFY

6.16e-0558722563174
Pubmed

MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis.

ZFX ZFY

6.16e-0558729721210
Pubmed

Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway.

ZFX ZFY

6.16e-05587225164012
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SNAP91 SYNE2 ZMYND8 DCLK1

6.94e-058787412465718
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

WDR3 EEF1G MDN1 SHANK2 ORC3 NMT2 ZMYND8 TPX2 NSD1 ODF2 SPEN DCLK1 GNL3

8.70e-051497871331527615
Pubmed

Sequence and expression of murine cDNAs encoding Xlr3a and Xlr3b, defining a new X-linked lymphocyte-regulated Xlr gene subfamily.

ZFX ZFY

9.22e-0568727821804
Pubmed

Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis.

ARHGAP4 GAS7

9.22e-05687226702831
Pubmed

Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.

EEF1G NUP107 SYNE2 CDK5RAP2

1.24e-0410187426949739
Pubmed

The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region.

KDM5D ZFY

1.29e-0478729736773
Pubmed

Genetic mapping in the mouse of Kif4, a gene encoding a kinesin-like motor protein.

ZFX ZFY

1.29e-0478729196009
Pubmed

Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.

ZFX ZFY

1.29e-0478728378320
Pubmed

The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation.

ZFX ZFY

1.29e-0478729588208
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

ZNF512B SRRM1 ZMYND8 SPEN

1.34e-0410387432744500
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

ZNF512B WDR3 SRRM1 MDN1 ZMYND8 DDX39A SPEN GNL3

1.40e-0460587828977666
Pubmed

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.

NSD1 SPEN ZFX ZFY

1.66e-0410987433554859
Pubmed

Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome.

ZFX ZFY

1.72e-0488722034279
Pubmed

Y chromosome short arm-Sxr recombination in XSxr/Y males causes deletion of Rbm and XY female sex reversal.

KDM5D ZFY

1.72e-0488727479793
Pubmed

The nucleoporin MEL-28 promotes RanGTP-dependent γ-tubulin recruitment and microtubule nucleation in mitotic spindle formation.

NUP107 TPX2

1.72e-04887224509916
Pubmed

Hereditary disorders of the red cell in animals.

EXOC6 CDK5RAP2

1.72e-0488724596202
Pubmed

Genetic mapping in the region of the mouse X-inactivation center.

ZFX ZFY

1.72e-0488721974879
Pubmed

Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.

PRKX PRKY

1.72e-04887222641646
Pubmed

High-density molecular map of the central span of the mouse X chromosome.

ZFX ZFY

1.72e-0488721675191
Pubmed

EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.

EEF1G NAA15 DSTN ORC3 VPS35 KDM5D DDX39A IFIT1 DCLK1

1.84e-0480387936517590
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

TPK1 EXOC6 MDN1 ORC3 SYNE2 CDK5RAP2 SPEN IFIT1

2.01e-0463887831182584
Pubmed

Praja1, a novel gene encoding a RING-H2 motif in mouse development.

ZFX ZFY

2.20e-0498729393880
Pubmed

exma: an X-linked insertional mutation that disrupts forebrain and eye development.

ZFX ZFY

2.20e-04987211956759
Pubmed

Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes.

ZFX ZFY

2.20e-0498727590750
Pubmed

Cloning and characterization of a new human Xq13 gene, encoding a putative helicase.

ZFX ZFY

2.20e-0498727874112
Pubmed

The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter.

ZFX ZFY

2.20e-0498729300697
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

WDR3 SRRM1 EEF1G DSTN MDN1 ORC3 SMC6 ZMYND8 TPX2 GNL3

2.23e-041014871032416067
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

EEF1G NAA15 NMT2 VPS35 TPX2 PDIA5 IFIT1 GNL3

2.35e-0465387833742100
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

ZNF512B WDR3 SRRM1 EEF1G MDN1 NUP107 SYNE2 SPEN FYN GNL3

2.41e-041024871024711643
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

ZNF512B WDR3 SRRM1 MDN1 NUP107 ZMYND8 TPX2 DDX39A ZFY

2.72e-0484787935850772
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF729 GFI1B ZNF846 ZNF485 ZNF75A ZNF317 PRDM15 ZFX ZFY

5.62e-0471860928
GeneFamilyParkinson disease associated genes

VPS35 LRRK2

1.26e-0316602672
GeneFamilyPWWP domain containing

ZMYND8 NSD1

2.40e-03226021147
GeneFamilyRho GTPase activating proteins|F-BAR domain containing

ARHGAP4 GAS7

2.62e-03236021288
GeneFamilyPHD finger proteins

ZMYND8 NSD1 KDM5D

3.33e-039060388
CoexpressionHE_LIM_SUN_FETAL_LUNG_C4_CYCLING_T_CELL

EXOC6 HAUS8 C5orf34 NUP107 ORC3 SYNE2 SMC6 TPX2 CDK5RAP2 EXOG ANKRD36 ANKRD36C ODF2 TUBD1

2.15e-069398614M45768
CoexpressionRUNNE_GENDER_EFFECT_UP

KDM5D PRKY ZFY

2.82e-069863M17072
CoexpressionFISCHER_DREAM_TARGETS

SRRM1 HAUS8 C5orf34 NAA15 NUP107 ORC3 GARS1 SMC6 TPX2 CDK5RAP2 ODF2 DDX39A TUBD1 GNL3

3.09e-069698614M149
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

SYT15B SYNE2 ANKRD36 ANKRD36C KDM5D PRKY

1.41e-0712187619333a660800b583fa27b495c1f7828e6636a257
ToppCellNS-critical-d_0-4-Lymphoid-CTL|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NMT2 SYNE2 APOBEC3G ANKRD36 FYN PRKX

1.93e-06189876fb7572fb4c7c43886d57a025decad076f32a14c4
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_T-CytoT_GZMH+-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DSTN SYNE2 APOBEC3G KDM5D FYN ZFY

2.05e-06191876b2d0ea24970da09209da9d9dda76e30fbfe22917
ToppCellnormal-na-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

SYNE2 ANKRD36 KDM5D FYN ZFY

1.34e-0515587508295584395e8d9cfc1b1648f98754b3ac53e587
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T4_reg-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SYNE2 CCR4 ANKRD36 KDM5D ZFY

2.21e-051728759497948bbe53fb88c6ff6b347f743d456da587e5
ToppCellnormal-na-Lymphocytic_T-CytoT_GZMK+-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

SYNE2 ANKRD36 KDM5D FYN ZFY

2.97e-0518387579defd22b3194dad16db55b9bdd220c09c1e6b90
ToppCelldroplet-Liver-Hepatocytes-21m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPK1 EXOC6 LRRK2 EXOG TUBD1

3.13e-05185875efcfbf5a48b3ea9a425183e5c2eec6a9585415a0
ToppCelldroplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPK1 EXOC6 LRRK2 EXOG TUBD1

3.13e-05185875642088ace9230d38b0579853c54ff4dd8b5d5df4
ToppCellnormal-na-Lymphocytic_T-CytoT_GZMH+-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

SYNE2 APOBEC3G KDM5D FYN ZFY

3.13e-05185875097d628f92e13250c15b550f2fd1f4225fc07558
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TPK1 SLC6A6 LRRK2 ADAMTS16 CFAP43

3.21e-051868755c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHANK2 ADAMTS16 ALDH1L1 CYP39A1 KLK1

3.30e-051878759aa411ae9b5a923378a5daebb8bb2fc2613f2510
ToppCellCOVID-19-kidney-DCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

TRPM6 NEXMIF ADAMTS16 HKDC1 ALDH1L1

3.38e-051888751d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DSTN NMT2 SYNE2 HKDC1 CCR4

3.38e-05188875fe08277d5aa693a2e12786738d12ec6390e8d13d
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SECISBP2L SLC6A6 SHANK2 LRRK2 PRKG2

3.56e-051908758aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCellCF-Lymphoid-B_cell|CF / Disease state, Lineage and Cell class

MDN1 ZC3H8 SMC6 APOBEC3G PRKX

3.56e-05190875374d8fd63c733178acab07682ed1519693efab45
ToppCellIPF-Lymphoid-T_Cytotoxic|IPF / Disease state, Lineage and Cell class

SYNE2 APOBEC3G FYN PRKX PRKY

3.56e-05190875e5d0186bfb416a3eda76ac12b9379650afb6f409
ToppCellSevere-Lymphoid-T-NK|Severe / Condition, Lineage, Cell class and cell subclass

SYNE2 TPX2 APOBEC3G FYN PRKX

3.56e-0519087560642de433f84fa2cecd796c3a1a4aab9219d3db
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD8|bone_marrow / Manually curated celltypes from each tissue

SYNE2 APOBEC3G KDM5D FYN PRKY

3.56e-05190875be281c7c717c11ef3c5cbccd22628acf1bd9727f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A6 AFF2 LRRK2 ADAMTS16 HKDC1

3.65e-051918751cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAMTS16 GAS7 PRKG2 FYN DCLK1

3.74e-0519287530cefa0990ba1f379f350bfbf994a78db145075e
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

SYNE2 ANKRD36 ANKRD36C FYN PRKY

3.74e-0519287547646d7e4990be85072987f92bf18d52f8da752e
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMH+-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DSTN SYNE2 APOBEC3G KDM5D FYN

3.74e-05192875fdc741e1846cfd8ed741b160e3c611c310c5d36d
ToppCellCF-Lymphoid|CF / Disease state, Lineage and Cell class

MDN1 ZC3H8 SMC6 APOBEC3G PRKX

3.83e-0519387511de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCellsevere_influenza-NK|severe_influenza / disease group, cell group and cell class (v2)

DSTN SYNE2 APOBEC3G ANKRD36C FYN

4.33e-05198875d431beb870ff5e165d98febfb27049d729e37dc8
ToppCellmild_COVID-19_(asymptomatic)-CD4+_CTL|World / disease group, cell group and cell class (v2)

DSTN SYNE2 APOBEC3G CFAP43 IFIT1

4.33e-0519887503c01fc384d46eec55ff730edbab8a3fde618ed8
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

SRRM1 SYNE2 SMC6 ANKRD36 FYN

4.43e-05199875c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

SRRM1 NAA15 SYNE2 SMC6 FYN

4.43e-05199875a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-NK|Influenza_Severe / Disease, condition lineage and cell class

DSTN SYNE2 APOBEC3G ANKRD36C FYN

4.54e-0520087504ac14414d550b14dc46d682e7af9dd43982211a
ToppCellsevere-CD8+_Tem|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SRRM1 DSTN SYNE2 APOBEC3G FYN

4.54e-052008756aa77955017d073a96324e4db6b9950a2ec46cf8
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

TANK DSTN SYNE2 KDM5D ZFY

4.54e-052008752d167b6e3f4b47e537b2e5b9b2f104f80573970b
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Cerebellum / BrainAtlas - Mouse McCarroll V32

AFF2 INSRR ADAMTS16 HKDC1

2.08e-041498746e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

SYNE2 ANKRD36 ANKRD36C FYN

2.19e-04151874999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

SYNE2 ANKRD36 CFAP43 PRKY

2.47e-0415687410d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

SYNE2 ANKRD36 ANKRD36C FYN

2.47e-041568741545169694f686d28648a68b552c2ae606599d66
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

SYNE2 ANKRD36 PLCD1 ANKRD36C

2.47e-04156874afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCellURO-Lymphocyte-T_NK-CD4_TEM|URO / Disease, Lineage and Cell Type

NMT2 SYNE2 HKDC1 FYN

2.73e-04160874e406f77b1c1a01d74f39ba65f99d5f8c7d75faf1
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE2 CCR4 ANKRD36 FYN

2.86e-0416287480317c4253bf8e897782e562f29835f181c65b98
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

SYNE2 ANKRD36C KDM5D PRKY

2.86e-04162874b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCellCOVID-CD8-memory_CD4|COVID / Condition, Cell_class and T cell subcluster

SLC6A6 NEK5 PDIA5 DOP1A

2.86e-0416287422b2a32217d357146c117e618813d451510a1801
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A6 SHANK2 SYNE2 LRRK2

2.99e-041648741cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEK5 NEXMIF ADAMTS16 HKDC1

3.21e-04167874cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GAS7 FYN KLK1 DCLK1

3.28e-041688744b2d29a7843bf45922038c093ca7ec0600756adc
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Trm/em_CD8|GI_small-bowel / Manually curated celltypes from each tissue

APOBEC3G CCR4 FYN PRKY

3.35e-0416987417568e7aacfdcd96c469bae57d5ffad04954e9bd
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEK5 NEXMIF ADAMTS16 HKDC1

3.35e-0416987430141f76e9bfc2b4586429857c72dbc85ba65cc9
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

INSRR GAS7 FYN DCLK1

3.35e-041698746373562ab3b1765060212a6a53d6543e7e942e80
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

EEF1G CCR4 ANKRD36C FYN

3.43e-04170874adb625124832b0786a590e8f75b61e7263a1e0d4
ToppCell3'_v3-Lung-Lymphocytic_T_CD4/8-lo|Lung / Manually curated celltypes from each tissue

SYNE2 TPX2 APOBEC3G FYN

3.51e-04171874dfd4a15ab68ef5a9a1954b1b1540ae04017885a6
ToppCellnormal-na-Lymphocytic_T-T4_em-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

SYNE2 ANKRD36 KDM5D ZFY

3.51e-0417187461318a7aaf3bd8bdd28f8a8614ab4fdf2964b3a3
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AFF2 SNAP91 GAS7 DOP1A

3.51e-04171874b51bbeacb172e8b5de519ada85543d7ae9914b3c
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

SYNE2 ANKRD36 ANKRD36C PRKY

3.51e-041718742e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellNS-critical-LOC-Lymphoid-NK|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SYNE2 APOBEC3G FYN PRKX

3.51e-04171874adda76991d9b150bb8ccf3989b7cbbf41843cf0b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GAS7 FYN KLK1 DCLK1

3.51e-041718745d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCellfacs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 INSRR ALDH1L1 KLK1

3.59e-04172874bc1b889ac5e07b8324ae5837eca911f9c865e959
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TPX2 ODF2 DDX39A PRDM15

3.59e-041728747f3d0ef18f5df1ed80498d435b0378ca398c0b88
ToppCellMild-CD4+_T_Exhausted|World / Disease group and Cell class

ARHGAP4 EEF1G CCR4 IFIT1

3.59e-04172874efe68d9477aa873b1637ee689f298120303aa322
ToppCelldroplet-Spleen-SPLEEN|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GFI1B DSTN TPX2 KDM5D

3.59e-04172874d32731a56e113ff0ef7167b23959d69baf2068f9
ToppCellfacs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 INSRR ALDH1L1 KLK1

3.59e-04172874ba70b6110b70afb1870e8dcaf58c507b8c7d918e
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS4Y2 SYNE2 HKDC1 PRKG2

3.66e-04173874e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

HAUS8 NEXMIF TPX2 ANKRD36C

3.66e-0417387420889aa85e36ad3bafdb91b91e43964493c949f9
ToppCellfacs-Large_Intestine-Proximal-3m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS4Y2 SYNE2 HKDC1 PRKG2

3.66e-0417387499532bb768ee35fed939a377acb5215d3f8904bd
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

HAUS8 NEXMIF TPX2 ANKRD36C

3.66e-0417387446e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCelldroplet-Kidney-nan-18m-Epithelial-collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEXMIF NMT2 ADAMTS16 EXOG

3.91e-04176874533d544852038c0612aacf87f4b1c88ff7aace82
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRRM1 SYNE2 NSD1 IFIT1

4.08e-0417887401dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSTN AFF2 SYNE2 TPX2

4.08e-0417887415a99080e9f669572ab6d82934f324e6714846c1
ToppCelllung|World / shred on tissue and cell subclass

EEF1G DSTN SYNE2 LRRK2

4.08e-041788747b1e371272328d6b6c3994382d64281ffc737db2
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSTN AFF2 SYNE2 TPX2

4.08e-04178874200308e109abb7e6f8816a6f8cce6d56862d4098
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHANK2 SYNE2 LRRK2 PDIA5

4.17e-04179874fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCellfacs-Pancreas-Exocrine-18m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALDH1L1 CYP39A1 FYN KLK1

4.17e-04179874bbfbfb32773346080127055b5aafa36bbf7d0942
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

INSRR GAS7 FYN DCLK1

4.17e-04179874dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 AFF2 HKDC1 KLK1

4.26e-04180874fc5b9d0e3215652e490ca72d69f776e9725608b2
ToppCellnormal-na-Lymphocytic_NK-T_mait-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

SYNE2 KDM5D FYN ZFY

4.26e-04180874e66a8a61b3576ac37de7c559d16d4ed4f7a2fc78
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK2 SYNE2 HKDC1 ALDH1L1

4.26e-04180874358923e4228035a3e90e2957392089219e90dcd7
ToppCellAdult-Immune-natural_killer_cell-D175|Adult / Lineage, Cell type, age group and donor

SYNE2 APOBEC3G FYN PRKX

4.26e-04180874fc59e28f39e7d4fb1bcc7205202cf39224b70d7b
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 AFF2 HKDC1 KLK1

4.26e-041808746763b22f2383931c747b37cd0ae2f60b08f64d90
ToppCellRA-01._Fibroblast_I|World / Chamber and Cluster_Paper

AFF2 INSRR FYN DCLK1

4.35e-041818742b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCellCOVID-19_Severe-Neutrophil-|COVID-19_Severe / Disease condition and Cell class

TRPM6 SYNE2 LRRK2 CDK5RAP2

4.35e-041818745e5101195d5ff8c8ea7ddcf0bc4f4e03e64c01e0
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-secretory_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL25 USP51 NUP107 TPX2

4.35e-04181874b203b616584cdbd0bbb0e382b2916d0bd49d3526
ToppCellCOVID-19_Severe-Neutrophil|COVID-19_Severe / Disease condition and Cell class

TRPM6 SYNE2 LRRK2 CDK5RAP2

4.35e-04181874aa5e5fb0308b5e2ef918548c85529c9a433c57f5
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL25 USP51 NUP107 TPX2

4.35e-04181874c748c16fd20d1949d33ff6290dc9d9016c4dc86c
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSTN AFF2 SYNE2 TPX2

4.35e-04181874566249e04dd491e6287ad2101b7b1ab11031ed8b
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSTN AFF2 SYNE2 TPX2

4.35e-04181874db9528dc7cb0230e4c36cb27da69102c588c7ee9
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c13-HAVCR2|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF729 NMT2 TPX2 HKDC1

4.44e-041828746c9a48037fa002bc528875538bdaaf15696d68b6
ToppCellIPF-Lymphoid-ILC_A|World / Disease state, Lineage and Cell class

APOBEC3G FYN PRKX PRKY

4.44e-04182874f91bb45baaec76cb3bb26eedbcf0709b2492e93f
ToppCellCOVID-19-kidney-PCT-S1|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK2 SYNE2 HKDC1 ALDH1L1

4.53e-041838746878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCellB_cells-ISG-high_B_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

SECISBP2L SMC6 IFIT1 DOP1A

4.53e-04183874dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCellIPF-Lymphoid-ILC_A|IPF / Disease state, Lineage and Cell class

APOBEC3G FYN PRKX PRKY

4.53e-0418387449bfeaae13eb236f61a5486ee75c39789936bb8a
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SECISBP2L SHANK2 LRRK2 PDIA5

4.72e-041858740d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCellCOPD-Lymphoid-T_Regulatory|COPD / Disease state, Lineage and Cell class

ZC3H8 SYNE2 CCR4 FYN

4.72e-04185874846403edd4c8f646201d519055198fc38b7ffff9
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS4Y2 PDIA5 ALDH1L1 KLK1

4.72e-04185874fd1911b57927c03470f9387962ca9581e5643fb3
ToppCellfacs-Large_Intestine-Distal-3m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS4Y2 PDIA5 ALDH1L1 KLK1

4.72e-041858747a18d525de6f874924bfc61b9666b307da86421a
ToppCellNK-T_cells|World / lung cells shred on cell class, cell subclass, sample id

ORC3 SYNE2 APOBEC3G FYN

4.82e-04186874279ab91ebca37a39b8907409e07f8b533df67542
ToppCellEpithelial-C_(AT2)|World / shred on cell class and cell subclass (v4)

SECISBP2L NEXMIF LRRK2 HKDC1

4.82e-04186874b7b1763fc52b4485d843a4a6727055e6c95ebad3
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE2 LRRK2 CFAP43 PRKX

4.82e-04186874f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE2 LRRK2 CFAP43 PRKX

4.91e-04187874c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellpdx-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

EXOC6 ZMYND8 CYP39A1 FYN

4.91e-041878747e376831a11ee72ed87abcdac631ca46ae29c250
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 DSTN ADAMTS16 PLCD1

4.91e-0418787477886f99c229610abd28c4c370d2c7d1536c9782
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK2 SYNE2 HKDC1 ALDH1L1

4.91e-04187874d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

SYNE2 ANKRD36 ANKRD36C SPEN

5.01e-04188874ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellMast_cells|World / lung cells shred on cell class, cell subclass, sample id

GFI1B AFF2 ORC3 NMT2

5.01e-04188874229d24b87e945c4d543d11ac70761e45175ba0e5
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_T-CytoT_GZMK+-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SYNE2 KDM5D FYN ZFY

5.01e-041888742513ca0efa73c09a3406b99e2876982d78b173d7
Diseasecryptorchidism (implicated_via_orthology)

SYNE2 ADAMTS16

2.28e-053822DOID:11383 (implicated_via_orthology)
Diseaseautism spectrum disorder (implicated_via_orthology)

ZNF280A NAA15 SHANK2 NEXMIF KDM5D

6.73e-05152825DOID:0060041 (implicated_via_orthology)
Diseasemicrocephaly (is_implicated_in)

NSD1 CDK5RAP2

2.11e-048822DOID:10907 (is_implicated_in)
Diseasesyndromic intellectual disability (implicated_via_orthology)

ZMYND8 KDM5D

8.93e-0416822DOID:0050888 (implicated_via_orthology)
DiseaseSpermatogenic Failure, Nonobstructive, Y-Linked

RPS4Y2 KDM5D

8.93e-0416822C1839071
DiseaseSPERMATOGENIC FAILURE, Y-LINKED, 2

RPS4Y2 KDM5D

8.93e-0416822415000
DiseaseSpermatogenic failure, Y-linked, 2

RPS4Y2 KDM5D

8.93e-0416822cv:C1839071
Diseasebipolar disorder

ATP8B3 GFI1B SHANK2 SNAP91 ZMYND8 FYN GNL3

1.13e-03577827MONDO_0004985
Diseaseplatelet component distribution width

GFI1B EXOC6 SRRM1 TANK ZMYND8 LRRK2 PDIA5 TUBD1

1.19e-03755828EFO_0007984
Diseaseintellectual disability (implicated_via_orthology)

ZNF280A NAA15 KDM5D

1.21e-0375823DOID:1059 (implicated_via_orthology)
DiseaseParkinson disease

VPS35 LRRK2

1.70e-0322822cv:C0030567
Diseaseglucose metabolism disease (implicated_via_orthology)

INSRR HKDC1

2.75e-0328822DOID:4194 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
LSCVKVLKNIKFMNH

ZNF280A

301

P59817
QKEKKDSHLMTFNLC

BTN2A3P

271

Q96KV6
VLDKMHKKNVENCKK

CFAP43

1556

Q8NDM7
KKDIFVAVKTCKKFH

B3GLCT

266

Q6Y288
LKNVKHFVLDECDKM

DDX39A

186

O00148
CAQEMAKFISKNKHV

APOBEC3G

291

Q9HC16
MQEAKKLKHKADALF

AFF2

1076

P51816
KDKKIRMEAHAKFAV

DOP1A

921

Q5JWR5
HCKNEKKNKAVKMIF

CCR4

231

P51679
MKCKDCVHLLKIKNT

ANKRD36

1361

A6QL64
KFFEMKKGQCKDALE

SNAP91

221

O60641
FDTKIMKNCGKIHLK

ATP8B3

356

O60423
KDAIKKKFQGIKHEC

DSTN

121

P60981
QFGEKAKLCMLDFKK

ADAMTS16

521

Q8TE57
MKAEVTKLHKKLFEQ

CDK5RAP2

1821

Q96SN8
HAAAKMQCKKVKNDD

NSD1

1476

Q96L73
MRKFLASKKHEAAKE

NUP107

696

P57740
KMLVNELNHSKEKKC

ANKRD36C

1641

Q5JPF3
SKEDIYAAKKHMKKC

nan

1081

O00370
CMNEEHKLSFLKKIF

MDN1

196

Q9NU22
KKAHVQKVTDFMLCV

KLK1

186

P06870
VKKMVEINFLCVHKK

NMT2

241

O60551
QFCGKRFHQKSDMKK

GFI1B

251

Q5VTD9
MAKDKDKTVHKKVTC

KDM5D

251

Q9BY66
IKKSKCRGKEHMIQN

DCLK1

421

O15075
ILEMNDKYVKKETCH

MORC3

731

Q14149
DSKHCVIKEINFEKM

NEK5

26

Q6P3R8
NMVKKQCFKNDIHKL

LRRK2

531

Q5S007
SKIMGDADRKHCKFK

EXOG

101

Q9Y2C4
MCKEKEKLQKKAHEL

HAUS8

181

Q9BT25
PNAHKKFMEKLDACI

EXOC6

41

Q8TAG9
KFMEKLDACIRNHDK

EXOC6

46

Q8TAG9
NVAFAMKCIRKKHIV

PRKG2

476

Q13237
KAMNKFGEALKKCHE

NAA15

496

Q9BXJ9
HSCLRKADKNKDNKM

PLCD1

146

P51178
FQKKTCIVHKMNKEV

GKN1

76

Q9NS71
MCDKIYQVDHKAKEI

KLHL25

306

Q9H0H3
KCKPKIKAVHMEACS

EFCAB7

511

A8K855
FLEEAQIMKKLKHDK

FYN

311

P06241
HRKAEENFQKLLCMK

IFIT1

356

P09914
EFLKEASVMKAFKCH

INSRR

1026

P14616
MEKEFGLCKTENKAK

GNL3

106

Q9BVP2
KKANLEKHSFLDCFM

CYP39A1

391

Q9NYL5
EVKLCEKMAQFDAKK

EEF1G

206

P26641
NEFHCQIMKSKETLK

C5orf34

196

Q96MH7
HPMDLCTLEKNAKKK

ZMYND8

191

Q9ULU4
KFHNLKAVVCKACMK

FAM120B

836

Q96EK7
GHCKKMKPEFEKAAE

PDIA5

306

Q14554
QKKHLQQEKECLMSK

ODF2

196

Q5BJF6
LQAKDCPDMKHFLQK

ORC3

136

Q9UBD5
MATKEKLQCLKDFHK

SLC6A6

1

P31641
EIHLMKDKAKHLDKC

SYNE2

1366

Q8WXH0
KDKAKHLDKCLKMLD

SYNE2

1371

Q8WXH0
ADCLADFMKTKDLKH

HKDC1

131

Q2TB90
KCKGKHMEREQVHKD

NEXMIF

1461

Q5QGS0
MKLHKGIKEYECKEC

PRDM15

1131

P57071
NFRENFKKDMKKCDH

GAS7

306

O60861
FKKDMKKCDHHIADL

GAS7

311

O60861
VKEKTAKHFFALKVM

PRKY

66

O43930
HLQKLMSDKKCSVEK

GARS1

221

P41250
VKKICMQHFLKIDGK

RPS4Y2

61

Q8TD47
KEEFHKICMLAKAQK

TANK

146

Q92844
KICMLAKAQKDHLSK

TANK

151

Q92844
TKHMKLNKIKCVIIS

SECISBP2L

726

Q93073
EKRQAKFMEHKLKCT

ARHGAP4

226

P98171
KFMEHKLKCTKARNE

ARHGAP4

231

P98171
AKLHTKTNLKKCMDH

SHANK2

156

Q9UPX8
EEKNKKLMNECDHLK

ANKRD20A12P

71

Q8NF67
KHIMKSCAISNVKKV

ALDH1L1

656

O75891
NDAIHKICAKLMNIK

TUBD1

206

Q9UJT1
LLKDFFLSDKHKCIM

USP51

386

Q70EK9
EGKMPKCVKHEKAFN

ZNF846

166

Q147U1
SFRFHKEEKLMKICK

TRPM6

1541

Q9BX84
KKKRMDHVDFDICTK

SPEN

1226

Q96T58
KRCLDKNKLMDALKH

VPS35

31

Q96QK1
KQLKFAECLEKKVDM

SRRM1

26

Q8IYB3
VKVSLMNHNKFVKCK

SYT15B

371

X6R8R1
CQLHYKELKMKIRKN

SMC6

706

Q96SB8
TKAKEKEKAIDCMSH

TTC23L

51

Q6PF05
VKEKTAKHFFALKVM

PRKX

66

P51817
SKRKRQKENAMCEKH

TRIM60

86

Q495X7
HQIAKELFEQLKMKK

YY1AP1

121

Q9H869
KTLVGLKKHMEVCQK

ZNF512B

521

Q96KM6
KEKGANKMHKCKFCE

ZFX

511

P17010
KQELLKLMDRHKKDC

ZNF75A

141

Q96N20
TAKMKEHKAICKAAG

WDR3

771

Q9UNX4
KQHKKIHNKERAMKC

ZNF485

426

Q8NCK3
KKNHMVEKTYECKEC

ZNF317

381

Q96PQ6
QDHTDFTKCLKMLQK

TPK1

96

Q9H3S4
HKEKGANKMHKCKFC

ZFY

506

P08048
RKIFQCNKHMKVFHK

ZNF729

151

A6NN14
CKFDHDAEIEKKKEM

ZC3H8

211

Q8N5P1
EQKEKHHVKMKAKRC

TPX2

131

Q9ULW0