Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Pyrin domain binding	NLRP7 NLRP2	6.01e-05	3	90	2	GO:0032090
GeneOntologyMolecularFunction	anandamide 8,9 epoxidase activity	CYP2D7 CYP2D6	1.20e-04	4	90	2	GO:0062187
GeneOntologyMolecularFunction	anandamide 11,12 epoxidase activity	CYP2D7 CYP2D6	1.20e-04	4	90	2	GO:0062188
GeneOntologyMolecularFunction	steroid 21-monooxygenase activity	CYP2D7 CYP2D6	1.20e-04	4	90	2	GO:0004509
GeneOntologyMolecularFunction	progesterone 21-hydroxylase activity	CYP2D7 CYP2D6	1.20e-04	4	90	2	GO:0106309
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2D7 CYP2D6 CYP2F1	2.39e-04	27	90	3	GO:0008391
GeneOntologyMolecularFunction	anandamide 14,15 epoxidase activity	CYP2D7 CYP2D6	2.98e-04	6	90	2	GO:0062189
GeneOntologyMolecularFunction	anandamide epoxidase activity	CYP2D7 CYP2D6	2.98e-04	6	90	2	GO:0062186
GeneOntologyMolecularFunction	aromatase activity	CYP2D7 CYP2D6 CYP2F1	5.22e-04	35	90	3	GO:0070330
GeneOntologyMolecularFunction	RS domain binding	SRSF10 SRSF12	5.53e-04	8	90	2	GO:0050733
GeneOntologyMolecularFunction	aspartic-type endopeptidase inhibitor activity	NLRP7 NLRP2	7.09e-04	9	90	2	GO:0019828
GeneOntologyMolecularFunction	interleukin-1 binding	NLRP7 NLRP2	1.29e-03	12	90	2	GO:0019966
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2D7 CYP2D6 CYP2F1	1.40e-03	49	90	3	GO:0016712
GeneOntologyMolecularFunction	BH domain binding	BAK1 BCL2L1	1.76e-03	14	90	2	GO:0051400
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1S CACNA1H	1.76e-03	14	90	2	GO:0008331
GeneOntologyBiologicalProcess	ketone biosynthetic process	COQ8A CACNA1H PRKG1 WNT4 ALDOA	4.95e-06	57	90	5	GO:0042181
GeneOntologyBiologicalProcess	C21-steroid hormone metabolic process	CYP2D7 CYP2D6 CACNA1H WNT4	4.40e-05	45	90	4	GO:0008207
GeneOntologyBiologicalProcess	mitochondrion organization	LIG3 AKT3 VPS13D ATP5IF1 SNX7 BAK1 WDR35 AKT1 ATG14 BCL2L1 ATG4D	5.06e-05	589	90	11	GO:0007005
GeneOntologyBiologicalProcess	serotonin biosynthetic process from tryptophan	CYP2D7 CYP2D6	5.63e-05	3	90	2	GO:0006587
GeneOntologyBiologicalProcess	regulation of release of cytochrome c from mitochondria	BAK1 WDR35 AKT1 BCL2L1	6.70e-05	50	90	4	GO:0090199
GeneOntologyBiologicalProcess	regulation of mitochondrion organization	VPS13D ATP5IF1 BAK1 WDR35 AKT1 BCL2L1	7.73e-05	162	90	6	GO:0010821
GeneOntologyBiologicalProcess	regulation of ATF6-mediated unfolded protein response	ATF6 ATF6B	1.12e-04	4	90	2	GO:1903891
GeneOntologyBiologicalProcess	negative regulation of release of cytochrome c from mitochondria	BAK1 AKT1 BCL2L1	1.34e-04	23	90	3	GO:0090201
GeneOntologyBiologicalProcess	olefinic compound metabolic process	CYP2D7 CYP2D6 CYP2F1 CACNA1H PRKG1 WNT4	1.38e-04	180	90	6	GO:0120254
GeneOntologyBiologicalProcess	autophagy of mitochondrion	VPS13D ATP5IF1 SNX7 ATG14 ATG4D	1.43e-04	114	90	5	GO:0000422
GeneOntologyBiologicalProcess	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ATP5IF1 BAK1 BCL2L1	1.52e-04	24	90	3	GO:1901028
GeneOntologyBiologicalProcess	release of cytochrome c from mitochondria	BAK1 WDR35 AKT1 BCL2L1	1.99e-04	66	90	4	GO:0001836
GeneOntologyCellularComponent	tenascin complex	TNR TNXB	1.09e-04	4	90	2	GO:0090733
GeneOntologyCellularComponent	proximal neuron projection	TRIM46 SYT5	1.82e-04	5	90	2	GO:1990769
GeneOntologyCellularComponent	phosphatidylinositol 3-kinase complex, class III	ATG14 UVRAG	3.80e-04	7	90	2	GO:0035032
GeneOntologyCellularComponent	vacuole	CLCN6 ABCB9 HLA-DPB1 HLA-DQB2 VCAN SIGLEC14 SIGLEC5 PSMD1 CP ATG14 RAB14 UVRAG	5.34e-04	913	90	12	GO:0005773
GeneOntologyCellularComponent	lysosome	CLCN6 ABCB9 HLA-DPB1 HLA-DQB2 VCAN SIGLEC14 SIGLEC5 PSMD1 CP RAB14 UVRAG	7.14e-04	811	90	11	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	CLCN6 ABCB9 HLA-DPB1 HLA-DQB2 VCAN SIGLEC14 SIGLEC5 PSMD1 CP RAB14 UVRAG	7.14e-04	811	90	11	GO:0000323
GeneOntologyCellularComponent	perineuronal net	VCAN TNR	8.07e-04	10	90	2	GO:0072534
GeneOntologyCellularComponent	Bcl-2 family protein complex	BAK1 BCL2L1	8.07e-04	10	90	2	GO:0097136
GeneOntologyCellularComponent	perisynaptic extracellular matrix	VCAN TNR	9.83e-04	11	90	2	GO:0098966
GeneOntologyCellularComponent	synapse-associated extracellular matrix	VCAN TNR	1.39e-03	13	90	2	GO:0099535
Domain	UV_resistance/autophagy_Atg14	ATG14 UVRAG	2.25e-05	2	89	2	IPR018791
Domain	Atg14	ATG14 UVRAG	2.25e-05	2	89	2	PF10186
Domain	-	EPHB2 TRIM46 HLA-DPB1 HLA-DQB2 VCAN SIGLEC14 GBE1 SIGLEC5 TNR TNXB ALPK2 EPHA8	7.06e-05	663	89	12	2.60.40.10
Domain	Ig-like_fold	EPHB2 TRIM46 HLA-DPB1 HLA-DQB2 VCAN SIGLEC14 GBE1 SIGLEC5 TNR TNXB ALPK2 EPHA8	1.28e-04	706	89	12	IPR013783
Domain	Ig/MHC_CS	HLA-DPB1 HLA-DQB2 SIGLEC14 SIGLEC5	1.68e-04	58	89	4	IPR003006
Domain	IG_MHC	HLA-DPB1 HLA-DQB2 SIGLEC14 SIGLEC5	1.92e-04	60	89	4	PS00290
Domain	MHC_II_b_N	HLA-DPB1 HLA-DQB2	6.17e-04	8	89	2	PD000328
Domain	Bcl2_BH2_motif_CS	BAK1 BCL2L1	6.17e-04	8	89	2	IPR020726
Domain	Bcl2_BH3_motif_CS	BAK1 BCL2L1	6.17e-04	8	89	2	IPR020728
Domain	Bcl2_BH1_motif_CS	BAK1 BCL2L1	6.17e-04	8	89	2	IPR020717
Domain	MHC_II_beta	HLA-DPB1 HLA-DQB2	7.91e-04	9	89	2	PF00969
Domain	MHC_II_b_N	HLA-DPB1 HLA-DQB2	7.91e-04	9	89	2	IPR000353
Domain	MHC_II_beta	HLA-DPB1 HLA-DQB2	7.91e-04	9	89	2	SM00921
Domain	VDCCAlpha1	CACNA1S CACNA1H	9.86e-04	10	89	2	IPR002077
Domain	fn3	EPHB2 TRIM46 TNR TNXB EPHA8	1.07e-03	162	89	5	PF00041
Domain	BH1	BAK1 BCL2L1	1.20e-03	11	89	2	PS01080
Domain	Blc2_fam	BAK1 BCL2L1	1.20e-03	11	89	2	IPR026298
Domain	Bcl-2	BAK1 BCL2L1	1.44e-03	12	89	2	PF00452
Domain	EGF_2	EPHB2 CELSR1 VCAN TNR TNXB EPHA8	1.68e-03	265	89	6	PS01186
Domain	BCL2_FAMILY	BAK1 BCL2L1	1.69e-03	13	89	2	PS50062
Domain	Bcl2-like	BAK1 BCL2L1	1.69e-03	13	89	2	IPR002475
Domain	BH2	BAK1 BCL2L1	1.69e-03	13	89	2	PS01258
Domain	FN3	EPHB2 TRIM46 TNR TNXB EPHA8	1.92e-03	185	89	5	SM00060
Domain	RECEPTOR_TYR_KIN_V_2	EPHB2 EPHA8	1.97e-03	14	89	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB2 EPHA8	1.97e-03	14	89	2	PS00790
Domain	MHC_II_a/b_N	HLA-DPB1 HLA-DQB2	1.97e-03	14	89	2	IPR014745
Domain	Eph_TM	EPHB2 EPHA8	1.97e-03	14	89	2	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHB2 EPHA8	1.97e-03	14	89	2	IPR001426
Domain	EPH_lbd	EPHB2 EPHA8	1.97e-03	14	89	2	SM00615
Domain	Ephrin_lbd	EPHB2 EPHA8	1.97e-03	14	89	2	PF01404
Domain	-	HLA-DPB1 HLA-DQB2	1.97e-03	14	89	2	3.10.320.10
Domain	ATPase_dyneun-rel_AAA	VWA8 DNAH6	1.97e-03	14	89	2	IPR011704
Domain	EphA2_TM	EPHB2 EPHA8	1.97e-03	14	89	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHB2 EPHA8	1.97e-03	14	89	2	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHB2 EPHA8	1.97e-03	14	89	2	IPR001090
Domain	EPH_LBD	EPHB2 EPHA8	1.97e-03	14	89	2	PS51550
Domain	AAA_5	VWA8 DNAH6	1.97e-03	14	89	2	PF07728
Domain	AGC-kinase_C	AKT3 AKT1 PRKG1	2.42e-03	56	89	3	IPR000961
Domain	AGC_KINASE_CTER	AKT3 AKT1 PRKG1	2.42e-03	56	89	3	PS51285
Domain	S_TK_X	AKT3 AKT1 PRKG1	2.42e-03	56	89	3	SM00133
Domain	FN3	EPHB2 TRIM46 TNR TNXB EPHA8	2.63e-03	199	89	5	PS50853
Domain	-	ABCF3 ABCB9 NLRP7 VWA8 MOV10L1 CHD6 RAB14 NLRP2 DHX34 DNAH6	2.87e-03	746	89	10	3.40.50.300
Domain	BH3	BAK1 BCL2L1	2.91e-03	17	89	2	PS01259
Domain	FN3_dom	EPHB2 TRIM46 TNR TNXB EPHA8	3.24e-03	209	89	5	IPR003961
Domain	Synaptotagmin	PCLO SYT5	4.03e-03	20	89	2	IPR001565
Domain	RRM	HNRNPDL SRSF10 TRA2B ABT1 SRSF12	4.87e-03	230	89	5	PS50102
Domain	DAPIN	NLRP7 NLRP2	4.87e-03	22	89	2	PS50824
Domain	PYRIN	NLRP7 NLRP2	4.87e-03	22	89	2	PF02758
Domain	DAPIN	NLRP7 NLRP2	4.87e-03	22	89	2	IPR004020
Domain	PYRIN	NLRP7 NLRP2	4.87e-03	22	89	2	SM01289
Domain	AAA+_ATPase	ABCF3 ABCB9 VWA8 DNAH6	4.99e-03	144	89	4	IPR003593
Domain	AAA	ABCF3 ABCB9 VWA8 DNAH6	4.99e-03	144	89	4	SM00382
Domain	NACHT	NLRP7 NLRP2	5.32e-03	23	89	2	PS50837
Pathway	WP_REGULATION_OF_APOPTOSIS_BY_PARATHYROID_HORMONERELATED_PROTEIN	AKT3 BAK1 AKT1 BCL2L1	8.14e-06	25	74	4	M39533
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2D7 CYP2D6 CYP2F1	2.95e-05	12	74	3	MM14847
Pathway	REACTOME_FATTY_ACIDS	CYP2D7 CYP2D6 CYP2F1	1.07e-04	18	74	3	MM14841
Pathway	WP_SMALL_CELL_LUNG_CANCER	AKT3 BAK1 AKT1 BCL2L1 ITGA3	1.47e-04	96	74	5	M39834
Pathway	REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS	AKT3 BAK1 AKT1 BCL2L1	1.95e-04	55	74	4	M7455
Pathway	WP_SILDENAFIL_TREATMENT	AKT3 AKT1 PRKG1	2.28e-04	23	74	3	M46455
Pathway	KEGG_MEDICUS_VARIANT_LOSS_OF_NKX3_1_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	2.69e-04	5	74	2	M48999
Pathway	REACTOME_XENOBIOTICS	CYP2D7 CYP2D6 CYP2F1	2.94e-04	25	74	3	MM14846
Pathway	KEGG_MEDICUS_REFERENCE_MAGI_PTEN_SIGNALING_PATHWAY	AKT3 AKT1	4.02e-04	6	74	2	M47523
Pathway	WP_ALZHEIMERS_DISEASE	CACNA1S ATF6 AKT3 PSMD1 AKT1 ATG14 WNT4	4.30e-04	261	74	7	M42565
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PI3K_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	5.61e-04	7	74	2	M47407
Pathway	KEGG_MEDICUS_REFERENCE_ACH_CHRN_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	5.61e-04	7	74	2	M47790
Pathway	KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_E3_UBIQUITIN_LIGASE_MALIN	ATG14 UVRAG	5.61e-04	7	74	2	M47977
Pathway	REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY	AKT3 HLA-DPB1 HLA-DQB2 AKT1	6.10e-04	74	74	4	M17386
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	7.46e-04	8	74	2	M47399
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	7.46e-04	8	74	2	M47394
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	7.46e-04	8	74	2	M47395
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	7.46e-04	8	74	2	M47404
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	7.46e-04	8	74	2	M47405
Pathway	KEGG_MEDICUS_REFERENCE_P4_PR_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	7.46e-04	8	74	2	M47803
Pathway	REACTOME_RUNX2_REGULATES_GENES_INVOLVED_IN_CELL_MIGRATION	AKT3 AKT1	7.46e-04	8	74	2	M27806
Pathway	KEGG_MEDICUS_VARIANT_TGFA_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	7.46e-04	8	74	2	M47482
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	7.46e-04	8	74	2	M47498
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_RET_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	7.46e-04	8	74	2	M47715
Pathway	PID_PI3KCI_AKT_PATHWAY	AKT3 AKT1 BCL2L1	8.05e-04	35	74	3	M249
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	9.56e-04	9	74	2	M47397
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	9.56e-04	9	74	2	M47392
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	9.56e-04	9	74	2	M47391
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	9.56e-04	9	74	2	M47402
Pathway	KEGG_MEDICUS_REFERENCE_MEMBRANE_INITIATED_PROGESTERONE_SIGNALING_PATHWAY	AKT3 AKT1	9.56e-04	9	74	2	M47802
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_MET_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	9.56e-04	9	74	2	M47490
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	9.56e-04	9	74	2	M47481
Pathway	REACTOME_ESTROGEN_DEPENDENT_NUCLEAR_EVENTS_DOWNSTREAM_OF_ESR_MEMBRANE_SIGNALING	AKT3 AKT1	9.56e-04	9	74	2	MM15666
Pathway	KEGG_MEDICUS_REFERENCE_ICOSLG_ICOS_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	9.56e-04	9	74	2	M47972
Pathway	KEGG_SMALL_CELL_LUNG_CANCER	AKT3 AKT1 BCL2L1 ITGA3	9.83e-04	84	74	4	M3228
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING	AKT3 AKT1 ITGA3 RAB14 TNR ATF6B TNXB	1.02e-03	302	74	7	M39719
Pathway	KEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	1.19e-03	10	74	2	M47400
Pathway	KEGG_MEDICUS_REFERENCE_HGF_MET_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	1.19e-03	10	74	2	M47401
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CD28_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	1.19e-03	10	74	2	M47615
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS	AKT3 AKT1	1.19e-03	10	74	2	M27095
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS	AKT3 AKT1	1.19e-03	10	74	2	MM14778
Pathway	WP_NEURAL_CREST_CELL_MIGRATION_DURING_DEVELOPMENT	EPHB2 AKT3 AKT1	1.19e-03	40	74	3	M39798
Pathway	WP_PANCREATIC_ADENOCARCINOMA_PATHWAY	AKT3 BAK1 AKT1 BCL2L1	1.22e-03	89	74	4	M39732
Pathway	REACTOME_METABOLISM_OF_RNA	SART1 SMG8 SRSF10 TUT4 EDC3 TRA2B PSMD1 AKT1 LTV1 PRPF18 SRSF12	1.32e-03	724	74	11	M16843
Pathway	KEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	1.45e-03	11	74	2	M47797
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2D6 CYP2F1	1.45e-03	11	74	2	M27130
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	1.45e-03	11	74	2	M47403
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	1.45e-03	11	74	2	M47406
Pathway	KEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	1.45e-03	11	74	2	M47484
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	1.45e-03	11	74	2	M47499
Pathway	KEGG_MEDICUS_REFERENCE_NRG_ERBB4_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	1.45e-03	11	74	2	M47756
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01339	AKT3 AKT1	1.45e-03	11	74	2	M47791
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	1.45e-03	11	74	2	M47501
Pathway	WP_NEURAL_CREST_CELL_MIGRATION_IN_CANCER	EPHB2 AKT3 AKT1	1.47e-03	43	74	3	M39788
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY	AKT3 AKT1 ITGA3 RAB14 TNR ATF6B TNXB	1.58e-03	326	74	7	MM15917
Pathway	WP_ALZHEIMERS_DISEASE_AND_MIRNA_EFFECTS	CACNA1S ATF6 AKT3 PSMD1 AKT1 ATG14 WNT4	1.58e-03	326	74	7	M39379
Pathway	KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	1.73e-03	12	74	2	M47393
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01350	AKT3 AKT1	1.73e-03	12	74	2	M47798
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	AKT3 AKT1	1.73e-03	12	74	2	M47558
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	AKT3 AKT1	1.73e-03	12	74	2	M47559
Pathway	SA_PROGRAMMED_CELL_DEATH	BAK1 BCL2L1	1.73e-03	12	74	2	M13096
Pathway	REACTOME_SARS_COV_2_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS	AKT3 AKT1	1.73e-03	12	74	2	M45022
Pathway	REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS	AKT3 AKT1	1.73e-03	12	74	2	MM15657
Pathway	WP_RESOLVIN_E1_AND_RESOLVIN_D1_SIGNALING_DECREASE_INFLAMMATION	EPHB2 AKT1	1.73e-03	12	74	2	M45559
Pathway	REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR	ATF6 ATF6B	1.73e-03	12	74	2	MM14981
Pathway	REACTOME_BIOSYNTHESIS_OF_MARESINS	CYP2D7 CYP2D6	1.73e-03	12	74	2	MM15616
Pathway	REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS	AKT3 AKT1	1.73e-03	12	74	2	M27939
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL	AKT3 AKT1	1.73e-03	12	74	2	MM14777
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING	AKT3 AKT1	1.73e-03	12	74	2	MM14550
Pathway	REACTOME_ECM_PROTEOGLYCANS	VCAN TNR TNXB	1.91e-03	47	74	3	MM14925
Pathway	WP_PI3KAKT_SIGNALING	AKT3 AKT1 BCL2L1 ITGA3 TNR ATF6B TNXB	1.98e-03	339	74	7	M39736
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	2.04e-03	13	74	2	M47398
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	2.04e-03	13	74	2	M47603
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING	AKT3 AKT1	2.04e-03	13	74	2	M549
Pathway	KEGG_MEDICUS_REFERENCE_INTRINSIC_APOPTOTIC_PATHWAY	BAK1 BCL2L1	2.04e-03	13	74	2	M47434
Pathway	REACTOME_G1_S_TRANSITION	AKT3 POLE PSMD1 AKT1	2.17e-03	104	74	4	MM15376
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	2.37e-03	14	74	2	M47390
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS	AKT3 AKT1	2.37e-03	14	74	2	MM15341
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS	AKT3 AKT1	2.37e-03	14	74	2	M27638
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGFR_PI3K_NFKB_SIGNALING_PATHWAY	AKT3 AKT1	2.37e-03	14	74	2	M47467
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY	AKT3 AKT1	2.37e-03	14	74	2	M47536
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL	AKT3 AKT1	2.37e-03	14	74	2	M3862
Pathway	REACTOME_APOPTOSIS	AKT3 BAK1 PSMD1 AKT1 BCL2L1	2.48e-03	179	74	5	M15303
Pathway	WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT	AKT3 BAK1 AKT1 WNT4	2.65e-03	110	74	4	M39492
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	2.73e-03	15	74	2	M47389
Pathway	REACTOME_FATTY_ACIDS	CYP2D6 CYP2F1	2.73e-03	15	74	2	M27126
Pathway	KEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	2.73e-03	15	74	2	M47663
Pathway	REACTOME_ACTIVATION_OF_BAD_AND_TRANSLOCATION_TO_MITOCHONDRIA	AKT3 AKT1	2.73e-03	15	74	2	M26902
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	2.73e-03	15	74	2	M47475
Pathway	WP_RIOK1_AND_RIOK2_IN_EGFR_AND_PI3KMEDIATED_TUMORIGENESIS	AKT3 AKT1	2.73e-03	15	74	2	M48306
Pathway	KEGG_MEDICUS_REFERENCE_BCR_BCAP_CD19_PI3K_SIGNALING_PATHWAY	AKT3 AKT1	2.73e-03	15	74	2	M47971
Pathway	WP_FOCAL_ADHESION	AKT3 AKT1 ITGA3 TNR TNXB	2.99e-03	187	74	5	MM15913
Pubmed	Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice.	ATF6 BAK1 AKT1 BCL2L1	4.28e-07	24	90	4	19139267
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	HNRNPDL SART1 LIG3 SMG8 SRSF10 ABCF3 TRA2B CTR9 POLE EIF2B5 PSMD1 LTV1 ALDOA DHX34 PHIP	1.94e-06	1353	90	15	29467282
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	HNRNPDL SART1 SRSF10 ABCB9 CTR9 ZC3H13 EIF2B5 PSMD1 PCDH7 CCNK HEXIM2	5.21e-06	774	90	11	15302935
Pubmed	Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos.	AKT3 AKT1 BCL2L1	5.97e-06	14	90	3	12773577
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	HNRNPDL ATF6 VPS13D SRSF10 TUT4 ATP5IF1 TRA2B VWA8 POLE PCLO GPAT3 PSMD1 ZCCHC17 PHIP FAM83B	6.55e-06	1496	90	15	32877691
Pubmed	Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.	SIGLEC14 SIGLEC5	6.62e-06	2	90	2	24799499
Pubmed	NLRP2 controls age-associated maternal fertility.	NLRP7 NLRP2	6.62e-06	2	90	2	27881734
Pubmed	Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not Improved by IVF or Embryo Transfer Consistent with Oocyte-Specific Defect.	NLRP7 NLRP2	6.62e-06	2	90	2	33090377
Pubmed	Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.	CYP2D7 CYP2D6	6.62e-06	2	90	2	25808902
Pubmed	Plasminogen K5 activates mitochondrial apoptosis pathway in endothelial cells by regulating Bak and Bcl-x(L) subcellular distribution.	BAK1 BCL2L1	6.62e-06	2	90	2	21656147
Pubmed	Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?	CYP2D7 CYP2D6	6.62e-06	2	90	2	11207030
Pubmed	N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha.	ATF6 ATF6B	6.62e-06	2	90	2	19693772
Pubmed	AKT isoforms 1 and 3 regulate basal and epidermal growth factor-stimulated SGHPL-5 trophoblast cell migration in humans.	AKT3 AKT1	6.62e-06	2	90	2	23303682
Pubmed	Akt3 deletion in mice impairs spatial cognition and hippocampal CA1 long long-term potentiation through downregulation of mTOR.	AKT3 AKT1	6.62e-06	2	90	2	30053339
Pubmed	Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL.	BAK1 BCL2L1	6.62e-06	2	90	2	11175750
Pubmed	Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.	CYP2D7 CYP2D6	6.62e-06	2	90	2	3123997
Pubmed	Mevalonate pathway orchestrates insulin signaling via RAB14 geranylgeranylation-mediated phosphorylation of AKT to regulate hepatic glucose metabolism.	AKT1 RAB14	6.62e-06	2	90	2	34995578
Pubmed	Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism involving inflammation and oxidative stress.	NLRP7 NLRP2	6.62e-06	2	90	2	30454891
Pubmed	Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth.	AKT3 AKT1	6.62e-06	2	90	2	25388284
Pubmed	NLRP2 inflammasome in dorsal root ganglion as a novel molecular platform that produces inflammatory pain hypersensitivity.	NLRP7 NLRP2	6.62e-06	2	90	2	31162334
Pubmed	Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein.	ANTXR1 BCL2L1	6.62e-06	2	90	2	11574549
Pubmed	Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.	SIGLEC14 SIGLEC5	6.62e-06	2	90	2	26459514
Pubmed	Intact piRNA pathway prevents L1 mobilization in male meiosis.	MOV10L1 TNR	6.62e-06	2	90	2	28630288
Pubmed	Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.	BAK1 BCL2L1	6.62e-06	2	90	2	9020082
Pubmed	Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis.	BAK1 BCL2L1	6.62e-06	2	90	2	10085290
Pubmed	NLRP2 is highly expressed in a mouse model of ischemic stroke.	NLRP7 NLRP2	6.62e-06	2	90	2	27693696
Pubmed	Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.	CYP2D7 CYP2D6	6.62e-06	2	90	2	11032406
Pubmed	Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B.	ATF6B TNXB	6.62e-06	2	90	2	7686164
Pubmed	NMR solution structure of a photoswitchable apoptosis activating Bak peptide bound to Bcl-xL.	BAK1 BCL2L1	6.62e-06	2	90	2	22515821
Pubmed	Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3.	EDC3 AKT1	6.62e-06	2	90	2	20051463
Pubmed	Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X(L).	BAK1 BCL2L1	6.62e-06	2	90	2	11964315
Pubmed	A genetic association study of NLRP2 and NLRP7 genes in idiopathic recurrent miscarriage.	NLRP7 NLRP2	6.62e-06	2	90	2	23360675
Pubmed	A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.	ATF6 ATF6B	6.62e-06	2	90	2	12782636
Pubmed	Alterations in the characteristic size distributions of subcellular scatterers at the onset of apoptosis: effect of Bcl-xL and Bax/Bak.	BAK1 BCL2L1	6.62e-06	2	90	2	20799797
Pubmed	Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung.	AKT3 AKT1	6.62e-06	2	90	2	20980808
Pubmed	Impaired Spatial Learning is Associated with Disrupted Integrity of the White Matter in Akt3 Knockout Mice.	AKT3 AKT1	6.62e-06	2	90	2	27671373
Pubmed	Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells.	AKT3 AKT1	6.62e-06	2	90	2	21777670
Pubmed	Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes.	ATF6B TNXB	6.62e-06	2	90	2	8923003
Pubmed	Nlrp2, a maternal effect gene required for early embryonic development in the mouse.	NLRP7 NLRP2	6.62e-06	2	90	2	22295082
Pubmed	The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.	CYP2D7 CYP2D6	6.62e-06	2	90	2	19594327
Pubmed	Bcl-xl and Bak protein expression in human optic nerve axons in eyeballs post-trauma and in the eyes with absolute glaucoma.	BAK1 BCL2L1	6.62e-06	2	90	2	15638362
Pubmed	Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.	CYP2D7 CYP2D6	6.62e-06	2	90	2	26297049
Pubmed	A system based on specific protein-RNA interactions for analysis of target protein-protein interactions in vitro: successful selection of membrane-bound Bak-Bcl-xL proteins in vitro.	BAK1 BCL2L1	6.62e-06	2	90	2	15292519
Pubmed	Partial limitation of cellular functions and compensatory modulation of unfolded protein response pathways caused by double-knockout of ATF6α and ATF6β.	ATF6 ATF6B	6.62e-06	2	90	2	38320450
Pubmed	Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress.	ATF6 ATF6B	6.62e-06	2	90	2	20631254
Pubmed	Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling.	AKT1 TNXB	6.62e-06	2	90	2	38819423
Pubmed	Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression.	AKT1 UVRAG	6.62e-06	2	90	2	23200933
Pubmed	A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.	CYP2D7 CYP2D6	6.62e-06	2	90	2	15051713
Pubmed	Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population.	HLA-DPB1 HLA-DQB2	6.62e-06	2	90	2	28613373
Pubmed	Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing.	SRSF10 SRSF12	6.62e-06	2	90	2	11684676
Pubmed	Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak.	BAK1 BCL2L1	6.62e-06	2	90	2	16794010
Pubmed	Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction.	ATF6 ATF6B	6.62e-06	2	90	2	14973138
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	HNRNPDL SART1 SRSF10 TUT4 TRA2B ZC3H13 ABT1 ZCCHC17 ALDOA DHX34 SRSF12	7.72e-06	807	90	11	22681889
Pubmed	Mosaic moles and non-familial biparental moles are not caused by mutations in NLRP7, NLRP2 or C6orf221.	NLRP7 NLRP2	1.98e-05	3	90	2	22909446
Pubmed	Deletion of PKBalpha/Akt1 affects thymic development.	AKT3 AKT1	1.98e-05	3	90	2	17912369
Pubmed	Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis through Bax activation in pancreatic cancer cells.	BAK1 BCL2L1	1.98e-05	3	90	2	23954445
Pubmed	Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B.	NLRP7 NLRP2	1.98e-05	3	90	2	36976514
Pubmed	Differential activation of AKT isoforms by growth factors in human myotubes.	AKT3 AKT1	1.98e-05	3	90	2	37879895
Pubmed	Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation.	VCAN AKT1	1.98e-05	3	90	2	38177536
Pubmed	Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.	BAK1 BCL2L1	1.98e-05	3	90	2	21911424
Pubmed	Maternal variants in NLRP and other maternal effect proteins are associated with multilocus imprinting disturbance in offspring.	NLRP7 NLRP2	1.98e-05	3	90	2	29574422
Pubmed	Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system.	EPHB2 EPHA8	1.98e-05	3	90	2	9321682
Pubmed	Differential prognostic values of the three AKT isoforms in acute myeloid leukemia.	AKT3 AKT1	1.98e-05	3	90	2	38528080
Pubmed	Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.	SIGLEC14 SIGLEC5	1.98e-05	3	90	2	11579105
Pubmed	Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions.	TNR TNXB	1.98e-05	3	90	2	7694605
Pubmed	Association of HLA-DP/DQ and STAT4 polymorphisms with ankylosing spondylitis in Southwest China.	HLA-DPB1 HLA-DQB2	1.98e-05	3	90	2	27394003
Pubmed	Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2.	AKT3 AKT1	1.98e-05	3	90	2	15987444
Pubmed	The protective effect of Bcl-xl overexpression against oxidative stress-induced vascular endothelial cell injury and the role of the Akt/eNOS pathway.	AKT1 BCL2L1	1.98e-05	3	90	2	24217227
Pubmed	Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice.	SIGLEC14 SIGLEC5	1.98e-05	3	90	2	30577572
Pubmed	Bcl-XL inhibits membrane permeabilization by competing with Bax.	BAK1 BCL2L1	1.98e-05	3	90	2	18547146
Pubmed	Role of Akt isoforms in IGF-I-mediated signaling and survival in myoblasts.	AKT3 AKT1	1.98e-05	3	90	2	19703413
Pubmed	MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.	AKT3 AKT1	1.98e-05	3	90	2	19825827
Pubmed	Kinetic mechanism of AKT/PKB enzyme family.	AKT3 AKT1	1.98e-05	3	90	2	16540465
Pubmed	A novel Siglec-F+ neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model.	SIGLEC14 SIGLEC5	1.98e-05	3	90	2	32247614
Pubmed	Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice.	AKT3 AKT1	1.98e-05	3	90	2	22632897
Pubmed	Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH.	AKT3 AKT1	1.98e-05	3	90	2	20102399
Pubmed	Distinct roles of the three Akt isoforms in lactogenic differentiation and involution.	AKT3 AKT1	1.98e-05	3	90	2	18561256
Pubmed	Differential effects of Akt isoforms on somatic cell reprogramming.	AKT3 AKT1	1.98e-05	3	90	2	25037569
Pubmed	All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines.	AKT3 AKT1	1.98e-05	3	90	2	38396845
Pubmed	Uncoupling of Pyrin-only protein 2 (POP2)-mediated dual regulation of NF-κB and the inflammasome.	NLRP7 NLRP2	1.98e-05	3	90	2	21976665
Pubmed	AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity.	AKT3 AKT1	1.98e-05	3	90	2	29173281
Pubmed	Akt/PKB isoforms expression in the human lumbar herniated disc: correlation with clinical and MRI findings.	AKT3 AKT1	1.98e-05	3	90	2	21590431
Pubmed	Bak interacts with AKT and is involved in TNFα/CHX-induced apoptosis.	BAK1 AKT1	1.98e-05	3	90	2	35094193
Pubmed	Protein kinase Akt activity in human thyroid tumors.	AKT3 AKT1	1.98e-05	3	90	2	29235817
Pubmed	Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L).	BAK1 BCL2L1	1.98e-05	3	90	2	19816507
Pubmed	Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors.	ATF6 ATF6B	1.98e-05	3	90	2	9837962
Pubmed	Immunohistological Examination of AKT Isoforms in the Brain: Cell-Type Specificity That May Underlie AKT's Role in Complex Brain Disorders and Neurological Disease.	AKT3 AKT1	1.98e-05	3	90	2	34296180
Pubmed	Delayed apoptosis by neutrophils from COPD patients is associated with altered Bak, Bcl-xl, and Mcl-1 mRNA expression.	BAK1 BCL2L1	1.98e-05	3	90	2	22686245
Pubmed	No evidence for mutations in NLRP7, NLRP2 or KHDC3L in women with unexplained recurrent pregnancy loss or infertility.	NLRP7 NLRP2	1.98e-05	3	90	2	25376457
Pubmed	Sex differences in the mechanism of Met5-enkephalin-induced cardioprotection: role of PI3K/Akt.	AKT3 AKT1	1.98e-05	3	90	2	17982014
Pubmed	Opposing functions of Akt isoforms in lung tumor initiation and progression.	AKT3 AKT1	1.98e-05	3	90	2	24722238
Pubmed	Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart.	ATF6 ATF6B	1.98e-05	3	90	2	30765833
Pubmed	The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety.	VCAN TNR	1.98e-05	3	90	2	9294172
Pubmed	Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG.	ATG14 UVRAG	1.98e-05	3	90	2	22314358
Pubmed	The AKT genes and their roles in various disorders.	AKT3 AKT1	1.98e-05	3	90	2	24039187
Pubmed	High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane.	BAK1 BCL2L1	1.98e-05	3	90	2	34523144
Pubmed	Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies.	AKT3 AKT1	1.98e-05	3	90	2	16923958
Pubmed	Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.	ATF6 ATF6B	1.98e-05	3	90	2	17765680
Pubmed	Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death.	AKT3 AKT1	1.98e-05	3	90	2	17202487
Pubmed	Specific Targeting of Akt Kinase Isoforms: Taking the Precise Path for Prevention and Treatment of Cancer.	AKT3 AKT1	1.98e-05	3	90	2	26953242
Interaction	MZT1 interactions	SRSF10 RGS19 ZC3H13 TUBGCP2 PRPF18	7.34e-06	61	89	5	int:MZT1
Cytoband	6p21.3	HLA-DPB1 BAK1 GRM4 RGL2 ATF6B TNXB	1.04e-05	250	90	6	6p21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr6p21	HLA-DPB1 HLA-DQB2 BAK1 GRM4 RGL2 ATF6B TNXB	6.20e-05	503	90	7	chr6p21
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	CELSR1 CYP2D7 CYP2D6 MOV10L1 SGSM3	4.96e-04	330	90	5	chr22q13
Cytoband	3q27.1	ABCF3 EIF2B5	1.29e-03	27	90	2	3q27.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3q27	ABCF3 TRA2B EIF2B5	2.08e-03	128	90	3	chr3q27
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	EPHB2 VPS13D SRSF10 CLCN6 WNT4 EPHA8	2.26e-03	681	90	6	chr1p36
GeneFamily	Cytochrome P450 family 2	CYP2D7 CYP2D6 CYP2F1	3.19e-04	35	69	3	1001
GeneFamily	RNA binding motif containing\|Serine and arginine rich splicing factors	SRSF10 SRSF12	9.24e-04	12	69	2	737
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB2 EPHA8	1.27e-03	14	69	2	1095
GeneFamily	BCL2 family	BAK1 BCL2L1	1.27e-03	14	69	2	1057
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	LIG3 PCLO	1.46e-03	15	69	2	26
GeneFamily	Fibronectin type III domain containing	EPHB2 TNR TNXB EPHA8	3.27e-03	160	69	4	555
GeneFamily	Zinc fingers CCHC-type\|RNA binding motif containing	TUT4 ZCCHC17	4.07e-03	25	69	2	74
GeneFamily	NLR family	NLRP7 NLRP2	4.07e-03	25	69	2	666
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP7 NLRP2	4.07e-03	25	69	2	994
GeneFamily	Fibrinogen C domain containing	TNR TNXB	4.07e-03	25	69	2	554
GeneFamily	Calcium voltage-gated channel subunits	CACNA1S CACNA1H	4.40e-03	26	69	2	253
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	SRSF10 TRA2B BCL2L1 PCDH7	5.06e-03	181	69	4	694
GeneFamily	CD molecules\|C2-set domain containing\|Sialic acid binding Ig like lectins	SIGLEC14 SIGLEC5	5.09e-03	28	69	2	745
GeneFamily	Autophagy related	ATG14 ATG4D	7.02e-03	33	69	2	1022
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PCLO UVRAG	8.32e-03	36	69	2	823
GeneFamily	RNA binding motif containing	HNRNPDL SRSF10 TRA2B SRSF12	8.91e-03	213	69	4	725
GeneFamily	C1-set domain containing	HLA-DPB1 HLA-DQB2	1.12e-02	42	69	2	591
GeneFamily	Histocompatibility complex\|C1-set domain containing	HLA-DPB1 HLA-DQB2	1.22e-02	44	69	2	588
GeneFamily	Basic leucine zipper proteins	ATF6 ATF6B	1.50e-02	49	69	2	506
Coexpression	GSE23321_CD8_STEM_CELL_MEMORY_VS_EFFECTOR_MEMORY_CD8_TCELL_DN	TUT4 RGS19 GBE1 TUBGCP2 RAB14 ALDOA FRMD4B	5.74e-06	199	90	7	M8430
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CELSR1 CYP2F1 SNX7 CP CHD6 PCDH7	2.99e-06	197	90	6	d6c9da7a3a6d2bcb13e2fc6605c8a59e7fb121c5
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CELSR1 CYP2F1 SNX7 CP CHD6 PCDH7	2.99e-06	197	90	6	80b05c8ad9c1edc5dea3236079372475431343fe
ToppCell	ILEUM-non-inflamed-(8)_Fibroblasts\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	VCAN ANTXR1 PRKG1 WNT4 PCDH7 TNXB	3.17e-06	199	90	6	d9d7f36b4b5592b7855448730044c90997b55499
ToppCell	ILEUM-inflamed-(8)_Fibroblasts\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	VCAN ANTXR1 CP PRKG1 PCDH7 TNXB	3.17e-06	199	90	6	3a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VCAN ANTXR1 CP PRKG1 PCDH7 TNXB	3.17e-06	199	90	6	6139687a3a5025cb98da4dba0183f95fcae3dc61
ToppCell	COVID-19_Convalescent-PLT_3\|World / Disease Group and Platelet Clusters	SMG8 VWA8 BAK1 CHD6 ALDOA	8.69e-06	137	90	5	bb54bb81b450462ad521b57e1a07a80ce1678e67
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VCAN ANTXR1 CP WNT4 PCDH7	2.39e-05	169	90	5	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	Healthy/Control-NK_CD56bright\|World / Disease group and Cell class	AKT3 CELSR1 CYP2F1 SYT5 TNR	2.53e-05	171	90	5	79d7efefdae267905af05f3001514b8b6934d86e
ToppCell	Control-B_naive-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TUT4 ATP5IF1 COQ8A HLA-DQB2 ICE2	2.53e-05	171	90	5	d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRIM46 CYP2F1 SIGLEC14 CP WNT4	2.60e-05	172	90	5	5401ac7739f95fb8681cfb4747ab6e447a3c2ae8
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRIM46 CYP2F1 SIGLEC14 CP WNT4	2.60e-05	172	90	5	b3da7f488d191214d7bb74fbac189fe8c29ee6cd
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRIM46 CYP2F1 SIGLEC14 CP WNT4	2.60e-05	172	90	5	74dd4a7acb2cf857fed20219e4d7dc1adfbaa398
ToppCell	facs-Skin-nan-24m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 WNT4 ITGA3 ALDOA TNXB	2.83e-05	175	90	5	21542be95059983d2c8bdf01ec711fdbf1ec1f62
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ATF6 CACNA1H ALPK2 EPHA8	2.91e-05	176	90	5	35610e7ac9902687e222641202409bab279c3998
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CELSR1 CP WNT4 PCDH7 FAM83B	2.99e-05	177	90	5	cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CELSR1 CP WNT4 PCDH7 FAM83B	2.99e-05	177	90	5	ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCell	Basal\|World / shred by cell class for mouse tongue	CELSR1 COQ8A ANTXR1 ITGA3 GRM4	3.50e-05	183	90	5	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	droplet-Thymus-nan-18m-Myeloid-Plasma_cells_and_B_cells\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ATF6 NACC2 CACNA1H ALPK2	3.50e-05	183	90	5	ffb1bbbccb34d1a7e99872611f497450039d5019
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ATF6 NACC2 SYT5 CACNA1H	3.59e-05	184	90	5	42cadfdb5d29a50bd7e901ddd14d42b39e8474f0
ToppCell	droplet-Thymus-nan-24m-Myeloid-Plasma_cells_and_B_cells\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ATF6 NACC2 CACNA1H ALPK2	3.69e-05	185	90	5	e583f6601f9ed79b0b23d2f9426a4ba8b969230b
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____podocyte-3\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM46 CP CACNA1H WNT4 DNAH6	3.78e-05	186	90	5	29c79b5a29907d4f3f87ad2ca04840c0f15b7d4e
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ABCF3 VCAN WDR35 FRMD4B HEXIM2	3.78e-05	186	90	5	74eb69a52090f9e2426a47e03a1c478ee0cfec18
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	VCAN ANTXR1 CACNA1H PRKG1 PCDH7	3.88e-05	187	90	5	464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ZC3H13 VCAN WDR35 ANTXR1 CHD6	3.98e-05	188	90	5	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	Healthy_donor-NK_CD56bright\|World / disease group, cell group and cell class (v2)	AKT3 CELSR1 SYT5 NLRP2 TNR	3.98e-05	188	90	5	8ee359199c61c3b5b498ac35148390db5cc1a836
ToppCell	facs-Lung-EPCAM-18m-Epithelial-Basal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB2 CYP2F1 COQ8A WNT4 FAM83B	4.08e-05	189	90	5	783c1db856f2defe6f3b8748dd0bc29a8102f6d1
ToppCell	facs-Lung-EPCAM-18m-Epithelial-respiratory_basal_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB2 CYP2F1 COQ8A WNT4 FAM83B	4.08e-05	189	90	5	88b72fafbe58463543e0818f27f3dd9e5b4d34d2
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-respiratory_basal_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB2 CELSR1 CYP2F1 WNT4 FAM83B	4.19e-05	190	90	5	47e07ea22733306d8885ee9e5f0b033e2f5e2afb
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_bronchioalveolar_tree\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB2 CELSR1 CYP2F1 WNT4 FAM83B	4.19e-05	190	90	5	261b8afddfdcba4f70b50df126cef7ad00a0aae0
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	VCAN ANTXR1 PRKG1 PCDH7 TNXB	4.19e-05	190	90	5	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VCAN ANTXR1 WNT4 TNXB ALPK2	4.29e-05	191	90	5	9214655dca96d766737c9f30b624d7fe7050342e
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	VCAN MOV10L1 CP PCDH7 FRMD4B	4.40e-05	192	90	5	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VCAN ANTXR1 PRKG1 PCDH7 TNXB	4.40e-05	192	90	5	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VCAN ANTXR1 PRKG1 PCDH7 TNXB	4.40e-05	192	90	5	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	facs-Aorta-Heart-3m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP2F1 VCAN ANTXR1 WNT4 ALPK2	4.40e-05	192	90	5	0dc1f46e40346ed0b286e53b106a812441575100
ToppCell	Monocytes-Tissue-resident_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	TUT4 HLA-DPB1 SNX7 HLA-DQB2 ANTXR1	4.51e-05	193	90	5	198552810dcac8d0ca63a78badd6702b49ff6edf
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	VCAN ANTXR1 PRKG1 PCDH7 FRMD4B	4.62e-05	194	90	5	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon\|organoid_Paulsen_bioRxiv / Sample Type, Dataset, Time_group, and Cell type.	ZC3H13 PCLO BCL2L1 ATF6B FRMD4B	4.62e-05	194	90	5	4903a0d6e36599bcb83b179462e5b949df9eb685
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	VCAN ANTXR1 PRKG1 PCDH7 FRMD4B	4.74e-05	195	90	5	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANTXR1 CP PRKG1 PCDH7 TNXB	4.74e-05	195	90	5	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-ciliated_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ATP5IF1 CYP2F1 SNX7 CP PCDH7	4.85e-05	196	90	5	d9426eba69047166ffa8179f1654e011c1020328
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VCAN ANTXR1 PRKG1 PCDH7 TNXB	4.85e-05	196	90	5	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ATP5IF1 CYP2F1 SNX7 CP PCDH7	4.85e-05	196	90	5	7e19919eafd6ddf547dd4e8aa532a050e182c5cc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VCAN ANTXR1 PRKG1 PCDH7 TNXB	4.85e-05	196	90	5	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP2F1 VCAN ANTXR1 WNT4 TNXB	4.85e-05	196	90	5	2029f58ce6a7b8c35d3a7496c3341391990909ce
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BRINP3 CHD6 GRM4 TNR PCDH7	4.97e-05	197	90	5	b8dc192fc98428bbb701cc2ea57fc8ad93397785
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AKT3 BRINP3 VCAN ANTXR1 TNXB	4.97e-05	197	90	5	6d0d68d460243a0259ada93ebda40fa7b3088eeb
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HLA-DPB1 RGS19 HLA-DQB2 GPAT3 SIGLEC5	5.09e-05	198	90	5	d73585a5587941483db8d9ddc2d68f7d852bbbc8
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VCAN CP WNT4 PCDH7 TNXB	5.09e-05	198	90	5	0f4052a59c6bd89dab637d6ef1214460d6cbcf55
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VCAN ANTXR1 PRKG1 PCDH7 TNXB	5.22e-05	199	90	5	a272c54baf8de59c0f259e6498d144a0de8d8924
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VCAN ANTXR1 CP PCDH7 TNXB	5.22e-05	199	90	5	36883044787a9fb79cf7e83a7da8e34eea83f2f1
ToppCell	ILEUM-inflamed-(8)_Fibroblast-(8)_Fibroblasts\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	VCAN CP WNT4 PCDH7 TNXB	5.22e-05	199	90	5	615f20bf136dfef53b072667cf0e4df6a1017e05
ToppCell	ILEUM-non-inflamed-(8)_Fibroblast\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	VCAN ANTXR1 PRKG1 PCDH7 TNXB	5.22e-05	199	90	5	6a0df9a2f30480043f9c1d7fbdede17eb0910cac
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CELSR1 ABCB9 CP WNT4 ITGA3	5.22e-05	199	90	5	f0c289523957258d16135c04679db379d43d28d9
ToppCell	ILEUM-non-inflamed-(8)_Fibroblast-(8)_Fibroblasts\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	VCAN CP WNT4 PCDH7 TNXB	5.22e-05	199	90	5	56d72da6a5fab9cbb2975fe6f87a631debaba6a8
ToppCell	10x3'2.3-week_12-13-Myeloid_monocytic-monocyte-CD14_monocyte\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	RGS19 VCAN GPAT3 SIGLEC14 SIGLEC5	5.34e-05	200	90	5	4984d27b3768be3b8fca3391cd2b7ab1749e2913
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VCAN CP PRKG1 PCDH7 TNXB	5.34e-05	200	90	5	c5d818203bef80ff97c2e0158cf61970673dd258
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VCAN ANTXR1 PRKG1 PCDH7 TNXB	5.34e-05	200	90	5	1801f10910aea899269025f24d1ca2d62168c6a6
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AKT3 VCAN ANTXR1 PRKG1 TNXB	5.34e-05	200	90	5	b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCell	Neuronal-Excitatory-eB(RORB)-SEMA3E-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	BRINP3 PCLO PRKG1 DNAH6 PCDH7	5.34e-05	200	90	5	1a3d29a580d1b405a74869a1da3e818c581fc559
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AKT3 VCAN ANTXR1 PRKG1 TNXB	5.34e-05	200	90	5	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VCAN ANTXR1 CP PCDH7 TNXB	5.34e-05	200	90	5	0655328373d1b58828e141ddb0dcbb2cce10dc50
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Dendritic_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HLA-DPB1 RGS19 HLA-DQB2 GPAT3 SIGLEC5	5.34e-05	200	90	5	41a206350eff2a196ccc1a36a9636a87c74f6962
ToppCell	Neuronal-Excitatory-eB(RORB)-SEMA3E---L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	BRINP3 PCLO PRKG1 DNAH6 PCDH7	5.34e-05	200	90	5	6f9ed8fe9cda91185c3a1a675353e11b8fec6ef1
ToppCell	Neuronal-Excitatory-eB(RORB)-SEMA3E--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	BRINP3 PCLO PRKG1 DNAH6 PCDH7	5.34e-05	200	90	5	86705dfc05b3e1576543b93883c88fb55b742855
ToppCell	Neuronal-Excitatory-eB(RORB)-SEMA3E\|Neuronal / cells hierarchy compared to all cells using T-Statistic	BRINP3 PCLO PRKG1 DNAH6 PCDH7	5.34e-05	200	90	5	db194b4f524fd008b3c5b4b6014b436190a1b87a
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Hpse_Cbln4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NACC2 GRM4 FRMD4B ALPK2	1.24e-04	126	90	4	94bd9cfe982b41a3114885173eab55feb0fbbbae
ToppCell	Cerebellum-Neuronal-Excitatory\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GLRA2 GPAT3 SYT5 ZCCHC17	1.32e-04	128	90	4	c30ba14320e9b98c9af9e4cd5a8c55380bb9ffa9
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-Tfh\|Lung / Manually curated celltypes from each tissue	TRIM46 CYP2F1 TNXB SRSF12	1.58e-04	134	90	4	da3cb572d0c19932619e51e272c0555e91b482ac
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DPB1 HLA-DQB2 GPAT3 FAM83B	1.72e-04	137	90	4	86c32cd26fe3b23c1dcd8ace580231c5a6ec6d9e
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HLA-DPB1 HLA-DQB2 GPAT3 FAM83B	1.72e-04	137	90	4	8989103606b15dff300e44c1590cd867b3cf7833
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BRINP3 GLRA2 CP CACNA1H	2.13e-04	145	90	4	78f5f4b96420c7f391e4d32a9ed151ed95fad90b
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BRINP3 NACC2 GLRA2 CP	2.13e-04	145	90	4	590ba937c741ae67460f303eca88b1cd3ac87f64
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	VCAN ANTXR1 DHX34 ALPK2	2.68e-04	154	90	4	c6ecc46b99a783373729f7fae0b23216148ffb78
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SNX7 HLA-DQB2 GBGT1 ANTXR1	2.75e-04	155	90	4	d76a0f99ec35560d18820f9c92b69364ef2250e3
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-Tfh\|Liver / Manually curated celltypes from each tissue	AKT3 CYP2D6 ABCB9 POLE	2.82e-04	156	90	4	85bc34ff507f9a66c6e3ba7a3ffd5416d0073ccf
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	VCAN BAK1 ITGA3 TNXB	3.03e-04	159	90	4	1472536eea61d4f13033efe42f128bae1614fa74
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CELSR1 CYP2F1 CP PCDH7	3.18e-04	161	90	4	2d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	EPHB2 NACC2 VWA8 CP	3.18e-04	161	90	4	22fea192cd5f6d3544533d8b10e1d74dfedf0f05
ToppCell	RV-13._Vascular_Smooth_Muscle\|RV / Chamber and Cluster_Paper	ANTXR1 CACNA1H PRKG1 ITGA3	3.18e-04	161	90	4	47b3b7662cbb671ccc086dc0a0cabd65f63eb5a1
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_5\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DPB1 HLA-DQB2 GPAT3 ALPK2	3.41e-04	164	90	4	3a4ecc632be003d09b765c992804134348d2278b
ToppCell	Adult-Epithelial-lung_goblet_cell-D175\|Adult / Lineage, Cell type, age group and donor	CYP2F1 CP GRM4 PCDH7	3.41e-04	164	90	4	6e6aedb61f8e195d52e028fdda750a29bb14e57e
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_5\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HLA-DPB1 HLA-DQB2 GPAT3 ALPK2	3.41e-04	164	90	4	4b10b78d4d76023c3c5bcd427757218fdd5465ca
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CELSR1 TUT4 HLA-DPB1 HLA-DQB2	3.49e-04	165	90	4	fead3f2032f8fa5f7f0159a4434989b3d65debbb
ToppCell	droplet-Thymus-nan-21m-Myeloid-Plasma_cells_and_B_cells\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ATF6 NACC2 CACNA1H	3.49e-04	165	90	4	21a82a975f550080b6674750b06212205cd16742
ToppCell	facs-Lung-Endomucin-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNRNPDL CLCN6 UVRAG PRPF18	3.57e-04	166	90	4	a2ce44702a0cd5fa5872cac3302d3c451205feef
ToppCell	facs-Lung-Endomucin-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNRNPDL CLCN6 UVRAG PRPF18	3.57e-04	166	90	4	0f641302a6b71c4badaaf20f51162bfc2386b167
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-cDC2\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HLA-DPB1 RGS19 HLA-DQB2 SIGLEC14	3.65e-04	167	90	4	1bd0aa7a3c8649f342bb856cf861c4c5984ad889
ToppCell	ICU-NoSEP-Myeloid-cDC2\|ICU-NoSEP / Disease, Lineage and Cell Type	HLA-DPB1 HLA-DQB2 GPAT3 UVRAG	3.65e-04	167	90	4	5b7b731944d888591279ef6167b3ae8cab3f6886
ToppCell	Adult-Epithelial-lung_goblet_cell-D122\|Adult / Lineage, Cell type, age group and donor	CELSR1 CYP2F1 CP PCDH7	3.65e-04	167	90	4	6efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCell	Control-Epithelial_airway-Club_cells-Airway\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CELSR1 CP WNT4 FAM83B	3.73e-04	168	90	4	ce87981f4da2779de952c2e5d2bbcdabb265e705
ToppCell	Control-Epithelial_airway-Club_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CELSR1 CP WNT4 FAM83B	3.73e-04	168	90	4	e85bc5398eb36b2b0773a8a7082e3ba740452165
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue-Endometrium-7\|TCGA-Endometrium / Sample_Type by Project: Shred V9	AKT3 CACNA1H PRKG1 TNXB	3.73e-04	168	90	4	a97e8e07ba949b30805aeed5f60fa5e092b9d3d4
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BRINP3 GLRA2 CP CACNA1H	3.90e-04	170	90	4	14aa86a4f526ed6986afcb28c49225522055550c
ToppCell	(7)_MNP-(7)_DC_activated\|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)	HLA-DQB2 UVRAG ALPK2 SRSF12	3.90e-04	170	90	4	4ab495b38a071fa8207331df2ce0d78a2dcd034e
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue-Endometrium\|TCGA-Endometrium / Sample_Type by Project: Shred V9	AKT3 CACNA1H PRKG1 TNXB	3.90e-04	170	90	4	cdc19013da7c41d1ed8400a6a643e4c684ff9912
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal\|TCGA-Endometrium / Sample_Type by Project: Shred V9	AKT3 CACNA1H PRKG1 TNXB	3.90e-04	170	90	4	0bde0a40440c7fdf7ba89cac8831d4014e7a4807
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue\|TCGA-Endometrium / Sample_Type by Project: Shred V9	AKT3 CACNA1H PRKG1 TNXB	3.90e-04	170	90	4	516b38c4ecf6b0b04c5d4f80c510dcc00b328c6f
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MOV10L1 ANTXR1 CP ALPK2	3.90e-04	170	90	4	7653f1205d4e62abe7e31b1d76f9bbd665e45667
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTR9 GPAT3 WDR35 HEXIM2	3.99e-04	171	90	4	d1e87478d8c0329e662849823f5c7604f20e1b1a
Drug	PNU-0230031 [267429-39-0]; Down 200; 10uM; MCF7; HT_HG-U133A	HNRNPDL LIG3 TUT4 ABCB9 CACNA1H WDR76 DHX34 PCDH7	1.15e-06	197	90	8	4754_DN
Drug	guanoxan	CYP2D7 CYP2D6 PHIP	4.93e-06	9	90	3	CID000016564
Drug	TCEO	CYP2D7 CYP2D6 CYP2F1 ALDOA	9.67e-06	34	90	4	CID000028167
Drug	M-NR	CYP2D7 CYP2D6 ALDOA NLRP2	1.09e-05	35	90	4	CID003000480
Drug	Furaltadone hydrochloride [3759-92-0]; Down 200; 11uM; MCF7; HT_HG-U133A	ATF6 TUT4 ANTXR1 BCL2L1 SGSM3 TUBGCP2 FRMD4B	1.33e-05	197	90	7	3838_DN
Drug	Gentamicine sulfate [1405-41-0]; Down 200; 2.6uM; PC3; HT_HG-U133A	EPHB2 LIG3 VPS13D EDC3 BCL2L1 SGSM3 DHX34	1.47e-05	200	90	7	5883_DN
Drug	cupreidine	CYP2D7 CYP2D6	1.55e-05	2	90	2	CID000051196
Drug	3-methoxyphenethylamine	CYP2D7 CYP2D6	1.55e-05	2	90	2	CID000074866
Drug	nebivolol	CYP2D7 CYP2D6 MOV10L1 EPHA8	1.87e-05	40	90	4	CID000071301
Drug	pyrazole	LIG3 ATF6 CYP2F1 BAK1 GBE1 ALDOA ATF6B	2.20e-05	213	90	7	ctd:C031280
Drug	TN-2	BAK1 BCL2L1 TNR TNXB	3.00e-05	45	90	4	CID006852143
Drug	terephthalamide	BAK1 BCL2L1	4.62e-05	3	90	2	CID000076381
Drug	2,4,6-trimethylbenzaldoxime	CYP2D7 CYP2D6	4.62e-05	3	90	2	CID000283782
Drug	O-demethyl encainide	CYP2D7 CYP2D6	4.62e-05	3	90	2	CID000054736
Drug	chlorpromazine N-oxide	CYP2D7 CYP2D6	4.62e-05	3	90	2	CID000443037
Drug	Sulf	CYP2D7 CYP2D6 ANTXR1 TNR	6.21e-05	54	90	4	CID003083599
Drug	casticin	ATF6 AKT3 TRA2B BAK1 AKT1 LTV1 BCL2L1	6.40e-05	252	90	7	ctd:C054133
Drug	1,2-dihydroxynaphthalene	CYP2D7 CYP2D6 CYP2F1 ALDOA	7.68e-05	57	90	4	CID000011318
Drug	NSC35549	CYP2D7 CYP2D6 CYP2F1	8.71e-05	22	90	3	CID000411697
Drug	veliparib	CYP2D6 BAK1 BCL2L1	8.71e-05	22	90	3	ctd:C521013
Drug	desethylaprindine	CYP2D7 CYP2D6	9.22e-05	4	90	2	CID000162697
Drug	3-ethylpyridine	TNR TNXB	9.22e-05	4	90	2	CID000010823
Drug	4,4'-difluorobenzophenone	CYP2D7 CYP2D6	9.22e-05	4	90	2	CID000009582
Drug	Z-10	CYP2D7 CYP2D6	9.22e-05	4	90	2	CID000477529
Drug	1-(1-phenylcyclohexyl)-4-piperidinol	CYP2D7 CYP2D6	9.22e-05	4	90	2	CID000098840
Drug	GBR 12909 dihydrochloride [67469-78-7]; Up 200; 7.6uM; MCF7; HT_HG-U133A	EPHB2 LIG3 ABCB9 VCAN GLRA2 FRMD4B	9.96e-05	187	90	6	3240_UP
Drug	Cephaloridine	POLE ZC3H13 BAK1 SIGLEC5 CACNA1H CHD6 BCL2L1 ALDOA PCDH7	1.01e-04	470	90	9	ctd:D002509
Drug	Dapsone [80-08-0]; Down 200; 16.2uM; PC3; HT_HG-U133A	LIG3 AKT3 ABCB9 VCAN TUBGCP2 WDR76	1.25e-04	195	90	6	5078_DN
Drug	Sulfamethoxypyridazine [80-35-3]; Down 200; 14.2uM; MCF7; HT_HG-U133A	LIG3 ABCB9 ZC3H13 AKT1 BCL2L1 WDR76	1.25e-04	195	90	6	3409_DN
Drug	Risperidone [106266-06-2]; Up 200; 9.8uM; MCF7; HT_HG-U133A	LIG3 TUT4 EDC3 CLCN6 ABCB9 ZC3H13	1.29e-04	196	90	6	3508_UP
Drug	Metyrapone [54-36-4]; Down 200; 17.6uM; PC3; HT_HG-U133A	EPHB2 AKT1 ZNF721 BCL2L1 SGSM3 WDR76	1.32e-04	197	90	6	4606_DN
Drug	Pyrithyldione [77-04-3]; Up 200; 24uM; PC3; HT_HG-U133A	VWA8 VCAN BCL2L1 SGSM3 TUBGCP2 DHX34	1.32e-04	197	90	6	7153_UP
Drug	alpha-Santonin [481-06-1]; Down 200; 16.2uM; MCF7; HT_HG-U133A	EPHB2 ATF6 PCLO CACNA1H DHX34 PCDH7	1.32e-04	197	90	6	3877_DN
Drug	Khellin [82-02-0]; Down 200; 15.4uM; MCF7; HT_HG-U133A	CLCN6 VWA8 BCL2L1 SGSM3 DHX34 PCDH7	1.32e-04	197	90	6	1504_DN
Drug	Metoclopramide monohydrochloride [7232-21-5]; Down 200; 11.8uM; MCF7; HT_HG-U133A	LIG3 VWA8 ZC3H13 PCLO TUBGCP2 PCDH7	1.36e-04	198	90	6	4750_DN
Drug	Aztreonam [78110-38-0]; Down 200; 9.2uM; PC3; HT_HG-U133A	EPHB2 AKT3 PCLO VCAN SGSM3 TUBGCP2	1.36e-04	198	90	6	5110_DN
Drug	cox-2 inhibitor I; Down 200; 10uM; MCF7; HG-U133A	EPHB2 ATF6 VPS13D TUT4 ZC3H13 PRKG1	1.40e-04	199	90	6	207_DN
Drug	eptapirone	CYP2D7 CYP2D6	1.53e-04	5	90	2	CID000208928
Drug	bathocuproine	CYP2D6 CP	1.53e-04	5	90	2	ctd:C002478
Drug	L-754,394	CYP2D7 CYP2D6	1.53e-04	5	90	2	CID005481990
Drug	4-hydroxyochratoxin A	CYP2D7 CYP2D6	1.53e-04	5	90	2	CID000114713
Drug	Koe 1801	CYP2D7 CYP2D6	1.53e-04	5	90	2	CID000129632
Drug	2Cmp	CYP2D7 CYP2D6	1.53e-04	5	90	2	CID000023392
Drug	oxosparteine	CYP2D7 CYP2D6	1.53e-04	5	90	2	CID000097492
Drug	threohydrobupropion	CYP2D7 CYP2D6	1.53e-04	5	90	2	CID000000445
Drug	fenproporex	CYP2D7 CYP2D6	1.53e-04	5	90	2	CID000061810
Drug	dopamine quinone	CACNA1S CYP2D7 CYP2D6 AKT1	1.62e-04	69	90	4	CID000162602
Drug	8(9)-EET	CYP2D7 CYP2D6 CYP2F1 AKT1	1.62e-04	69	90	4	CID000001901
Drug	BP-9,10-oxide	CYP2D7 CYP2D6 CYP2F1	1.63e-04	27	90	3	CID000037456
Drug	Brn 4136738	CYP2D7 CYP2D6 CYP2F1	1.63e-04	27	90	3	CID000050331
Drug	C14845	CYP2D7 CYP2D6 CYP2F1	1.63e-04	27	90	3	CID011954064
Disease	eosinophil count	AKT3 CELSR1 HLA-DPB1 HLA-DQB2 ICE2 BAK1 ANTXR1 SIGLEC5 ATG14 CACNA1H BCL2L1 ALDOA ATF6B TNXB UVRAG ALPK2	7.49e-06	1488	88	16	EFO_0004842
Disease	gastroparesis	HLA-DPB1 HLA-DQB2 PRKG1	1.40e-05	16	88	3	EFO_1000948
Disease	Sjogren syndrome	NACC2 HLA-DPB1 HLA-DQB2 PHIP	3.17e-05	60	88	4	EFO_0000699
Disease	ubiquitin carboxyl-terminal hydrolase 25 measurement	HLA-DQB2 ATF6B TNXB	3.79e-05	22	88	3	EFO_0021881
Disease	solanidine measurement	CYP2D7 CYP2D6	5.26e-05	4	88	2	EFO_0800966
Disease	eosinophil percentage of leukocytes	CELSR1 HLA-DPB1 HLA-DQB2 ICE2 BAK1 SIGLEC5 ATG14 BCL2L1 ALDOA ALPK2	7.68e-05	746	88	10	EFO_0007991
Disease	hepatitis B virus infection, Susceptibility to viral and mycobacterial infections	HLA-DPB1 HLA-DQB2	2.43e-04	8	88	2	EFO_0004197, Orphanet_391311
Disease	gdnf family receptor alpha-1 measurement	HLA-DQB2 TNXB	2.43e-04	8	88	2	EFO_0020400
Disease	pulmonary tuberculosis (is_implicated_in)	HLA-DPB1 GBE1 AKT1	2.70e-04	42	88	3	DOID:2957 (is_implicated_in)
Disease	complement C1q subcomponent subunit C measurement	EPHB2 EPHA8	3.90e-04	10	88	2	EFO_0801492
Disease	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 measurement	SIGLEC14 SIGLEC5	3.90e-04	10	88	2	EFO_0801544
Disease	platelet component distribution width	AKT3 HLA-DQB2 MOV10L1 SIGLEC14 ANTXR1 SIGLEC5 SYT5 ATG14 TNXB	4.23e-04	755	88	9	EFO_0007984
Disease	cAMP-specific 3',5'-cyclic phosphodiesterase 4D measurement	HLA-DQB2 TNXB	4.75e-04	11	88	2	EFO_0020224
Disease	Enzymopathy	PRKG1 ALDOA	4.75e-04	11	88	2	C0520572
Disease	complement C4 measurement	HLA-DQB2 ATF6B TNXB	5.10e-04	52	88	3	EFO_0004984
Disease	monocyte count	ATF6 AKT3 TRA2B HLA-DPB1 HLA-DQB2 VCAN SIGLEC14 SIGLEC5 SYT5 BCL2L1 GRM4 ALDOA	5.42e-04	1320	88	12	EFO_0005091
Disease	sialic acid-binding Ig-like lectin 14 measurement	SIGLEC14 SIGLEC5	5.69e-04	12	88	2	EFO_0008284
Disease	autoimmune hepatitis (is_implicated_in)	CYP2D6 HLA-DPB1	6.71e-04	13	88	2	DOID:2048 (is_implicated_in)
Disease	systemic lupus erythematosus, COVID-19	HLA-DQB2 GBGT1 TNXB	7.02e-04	58	88	3	MONDO_0007915, MONDO_0100096
Disease	liver neoplasm	HLA-DPB1 HLA-DQB2	9.00e-04	15	88	2	EFO_1001513
Disease	impotence (implicated_via_orthology)	AKT1 BCL2L1	9.00e-04	15	88	2	DOID:1875 (implicated_via_orthology)
Disease	tumor necrosis factor beta measurement	EPHB2 EPHA8	9.00e-04	15	88	2	EFO_0008308
Disease	rheumatoid arthritis, COVID-19	GBGT1 ABT1 TNXB	9.36e-04	64	88	3	EFO_0000685, MONDO_0100096
Disease	Glycogen storage disease	GBE1 ALDOA	1.16e-03	17	88	2	cv:C0017919
Disease	thyroxine measurement, triiodothyronine measurement	EPHB2 ABCB9	1.16e-03	17	88	2	EFO_0005130, EFO_0008392
Disease	brain connectivity measurement	AKT3 CYP2D7 CYP2D6 VCAN PCDH7 HEXIM2	1.27e-03	400	88	6	EFO_0005210
Disease	hepatitis B virus infection	HLA-DPB1 HLA-DQB2	1.45e-03	19	88	2	EFO_0004197
Disease	Amphetamine-Related Disorders	CYP2D6 AKT1 PRKG1	1.48e-03	75	88	3	C0236733
Disease	Amphetamine Abuse	CYP2D6 AKT1 PRKG1	1.48e-03	75	88	3	C0236807
Disease	Amphetamine Addiction	CYP2D6 AKT1 PRKG1	1.48e-03	75	88	3	C0236804
Disease	prostate adenocarcinoma (is_implicated_in)	AKT3 AKT1	1.61e-03	20	88	2	DOID:2526 (is_implicated_in)
Disease	Adenocarcinoma of prostate	EPHB2 AKT1	1.61e-03	20	88	2	C0007112
Disease	chronic myeloid leukemia (is_implicated_in)	AKT1 BCL2L1	1.78e-03	21	88	2	DOID:8552 (is_implicated_in)
Disease	susceptibility to shingles measurement	HLA-DQB2 PRKG1 TNXB	1.85e-03	81	88	3	EFO_0008401
Disease	breast cancer, COVID-19	TRIM46 GBGT1	1.95e-03	22	88	2	MONDO_0007254, MONDO_0100096
Disease	Nerve Degeneration	BAK1 CP GRM4	1.98e-03	83	88	3	C0027746
Disease	Drug toxicity	CYP2D6 CP CACNA1H	2.05e-03	84	88	3	C0013221
Disease	Adverse reaction to drug	CYP2D6 CP CACNA1H	2.05e-03	84	88	3	C0041755
Disease	malignant astrocytoma (is_marker_for)	AKT3 AKT1	2.14e-03	23	88	2	DOID:3069 (is_marker_for)
Disease	chronic hepatitis B virus infection	HLA-DPB1 HLA-DQB2	2.33e-03	24	88	2	EFO_0004239
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D7 CYP2D6	2.33e-03	24	88	2	EFO_0003761, EFO_0005658
Disease	carpal tunnel syndrome	HLA-DQB2 VCAN WNT4	2.42e-03	89	88	3	EFO_0004143
Disease	complement C4b measurement	ATF6B TNXB	2.52e-03	25	88	2	EFO_0008092
Disease	lysophosphatidylethanolamine 16:0 measurement	HLA-DQB2 TNR	2.73e-03	26	88	2	EFO_0010366
Disease	myeloperoxidase measurement	SMG8 TNXB	2.73e-03	26	88	2	EFO_0005243
Disease	macular degeneration (is_marker_for)	SRSF10 TRA2B	2.73e-03	26	88	2	DOID:4448 (is_marker_for)
Disease	Glycogen Storage Disease	GBE1 ALDOA	2.94e-03	27	88	2	C0017919

Protein segments in the cluster

Peptide	Gene	Start	Entry
RERVFSEDRARFYGA	AKT1	241	P31749
SEDRARFYGAEIVSA	AKT1	246	P31749
RSQEYTDFVDRSRQG	BRINP3	56	Q76B58
TDFVDRSRQGFSTRY	BRINP3	61	Q76B58
DLFFYSEREANRSRD	ANTXR1	156	Q9H6X2
SYERSTDGSFQDRFR	VCAN	2511	P13611
SGDFVYFDGRDRERF	ATG14	61	Q6ZNE5
IGDDINRRYDSEFQT	BAK1	81	Q16611
RADFRSYEENFQERG	ALPK2	1116	Q86TB3
SIGTENTEENRRFYR	ALDOA	46	P04075
VRGFDRYFSSRTLDN	GRM4	341	Q14833
YDVRIENFDVSFGDR	ABCF3	176	Q9NUQ8
EARYRREGARFIFDV	CCNK	46	O75909
REEFARFDSDVGEFR	HLA-DPB1	61	P04440
REAGDEFELRYRRAF	BCL2L1	91	Q07817
FFGREVDAEYEARSR	ARFGAP2	436	Q8N6H7
SYQDFFEAIRRRGDT	ATF6	551	P18850
GLFDERSRGYFRIDS	CELSR1	286	Q9NYQ6
RVFSEDRTRFYGAEI	AKT3	241	Q9Y243
DTAGQERFRAVTRSY	RAB14	66	P61106
SVLFGSRFDYDDERL	CYP2F1	181	P24903
NERRGFCFITYTDEE	HNRNPDL	271	O14979
REYTDASFTNRKERG	CP	426	P00450
SNEDRFEDDRYFLGF	MOV10L1	1111	Q9BXT6
RRAEQRKYGVFFDDD	LTV1	51	Q96GA3
RDRGSFEDSTTRFYT	PRKG1	451	Q13976
REEYGRFDSDVGEFQ	HLA-DQB2	66	P05538
TDNFDYQTRDDFVRG	EIF2B5	261	Q13144
VESFDEEFRTLYARS	FAM83B	266	Q5T0W9
NRRGFERADSEYTDK	EPHB2	566	P29323
REESRTRGYDRDIAF	PCLO	4406	Q9Y6V0
STFIEDYRDFDRVRV	ITGA3	936	P26006
TATDRDFGRNGIERY	PCDH7	166	O60245
ELREEGFRRSNYSEL	L1RE1	41	Q9UN81
GFRRSNYSELREDIQ	L1RE1	46	Q9UN81
FNGFYTERLERLSAE	TUBGCP2	861	Q9BSJ2
VEGFLEEDRRAYFLR	NLRP2	356	Q9NX02
NSFYVDTVRAFRDRR	POLE	751	Q07864
AAVFEEIDTYERRSG	EDC3	216	Q96F86
DFSRLRRYFVAFDGD	LIG3	951	P49916
GYERQRDYSRSFHED	FRMD4B	846	Q9Y2L6
ETDFYLQSVERGQRF	ABT1	181	Q9ULW3
YFRSDRDKRDFVSAG	CLCN6	231	P51797
FQRFARESGYSERVQ	DNAH6	3556	Q9C0G6
LEEYRFDGFRFDGVT	GBE1	346	Q04446
RFSRFSQREQRSYVD	ICE2	96	Q659A1
GRTRDETFYSTERYD	KLHL15	386	Q96M94
YERRRVSTAFVADSE	GBGT1	241	Q8N5D6
LRGRDFELSDVFYFS	GPAT3	86	Q53EU6
FGGRYDFEDTEVRRS	CACNA1S	581	Q13698
TRREQADFYRTVSSF	CHD6	1451	Q8TD26
YCFDQLRRRFGDVFS	CYP2D6	56	P10635
AGYTERQRRDFLSEA	EPHA8	671	P29322
GYFREARDVFAQVRE	CTR9	661	Q6PD62
LDFGATREYDRSFTD	COQ8A	506	Q8NI60
EEDVTRESRFNFSGY	GLRA2	361	P23416
AFGKREQAEEERYFR	ATP5IF1	46	Q9UII2
DSDGRGVYEFTQDVR	CACNA1H	721	O95180
DAFFREEDYIRQGSE	DHX34	41	Q14147
DIARAFVGFEYEDSR	SMG8	841	Q8ND04
YDFDRFSRNDAIGEV	SYT5	196	O00445
GEFEEFSRRIYALNE	UVRAG	671	Q9P2Y5
EEDGAVFTVTSRQYR	RGL2	61	O15211
RSVFRAFLRTEYSEE	RGS19	101	P49795
DYERGRVSFLDAVSF	TRIM46	696	Q7Z4K8
GEFQRKDFSETYERF	HEXIM2	186	Q96MH2
EVLYEDEGFRSRQFA	PSMD1	46	Q99460
AGREVERDFASVYSR	SGSM3	596	Q96HU1
EDTGSYFFRVERGRD	SIGLEC5	111	O15389
VEGFLEEDRRAYFLR	NLRP7	321	Q8WX94
GEFDSSEFEVRRRYQ	SNX7	61	Q9UNH6
RGFAYVQFEDVRDAE	SRSF12	51	Q8WXF0
EGRVDFENVTFTYRT	ABCB9	501	Q9NP78
DRREDTFYVVSFRRD	ATF6B	586	Q99941
YRFEGEGDIQRFQRD	ATG4D	101	Q86TL0
YCFDQLRRRFGDVFS	CYP2D7	56	A0A087X1C5
EQEERRRRSFQDYTG	ZCCHC17	106	Q9NP64
QGRRTAFYNEDDSEE	PHIP	1771	Q8WWQ0
RGFAYVQFEDVRDAE	SRSF10	51	O75494
NREKAYTGEDRDRAF	ZNF721	176	Q8TF20
RFDSFTVQYKDRDGR	TNXB	2121	P22105
RDGQEAAFASYDRFS	TNR	1231	Q92752
SRREEYRGFTQDFKE	SART1	686	O43290
SRAIFEEVYRNERSS	WDR76	391	Q9H967
YGVAFSQSFVDVRER	WNT4	161	P56705
DAATYERFSGAVRRQ	VWA8	1636	A3KMH1
EVVGYFGRFEEAERT	WDR35	746	Q9P2L0
GREAEYFFDSRVLTD	TUT4	1271	Q5TAX3
RLFGETDYDAFQRLR	PRPF18	96	Q99633
RRSRGFAFVYFENVD	TRA2B	156	P62995
EDTGSYFFRVERGRD	SIGLEC14	111	Q08ET2
GSFDSRDRLQERDRY	ZC3H13	1291	Q5T200
EFYRERFTTSGEEAL	VPS13D	1931	Q5THJ4
FEQRIYAERRGDAAT	NACC2	491	Q96BF6