Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	meiotic cell cycle process	PNMA5 TDRD9 INCENP MEIOSIN DICER1 SLX4 TEX19 KNL1	4.27e-06	268	72	8	GO:1903046
GeneOntologyBiologicalProcess	cellular anatomical entity morphogenesis	FLII FLNC PHLDB1 PDCL2 DICER1 KNL1	1.76e-05	156	72	6	GO:0032989
GeneOntologyBiologicalProcess	cellular component assembly involved in morphogenesis	FLII FLNC PHLDB1 PDCL2 DICER1 KNL1	1.76e-05	156	72	6	GO:0010927
GeneOntologyBiologicalProcess	meiotic nuclear division	PNMA5 TDRD9 INCENP MEIOSIN SLX4 TEX19 KNL1	2.05e-05	240	72	7	GO:0140013
GeneOntologyBiologicalProcess	meiotic cell cycle	PNMA5 TDRD9 INCENP MEIOSIN DICER1 SLX4 TEX19 KNL1	2.95e-05	350	72	8	GO:0051321
HumanPheno	Aplasia/Hypoplasia of the corpus callosum	FLII ERCC5 SLC12A2 ARHGAP31 CCDC174 PCLO SMARCB1 SHMT2 MACF1 CEP152 POGZ MAPKAPK5 TRRAP KNL1	1.51e-05	772	28	14	HP:0007370
Domain	ARHGEF5_35	ARHGEF35 ARHGEF5	1.51e-05	2	73	2	PF15441
Domain	ARHGEF5/35_N	ARHGEF35 ARHGEF5	1.51e-05	2	73	2	IPR029212
Domain	Actinin_actin-bd_CS	SPTBN5 FLNC MACF1	9.59e-05	23	73	3	IPR001589
Domain	ACTININ_2	SPTBN5 FLNC MACF1	9.59e-05	23	73	3	PS00020
Domain	ACTININ_1	SPTBN5 FLNC MACF1	9.59e-05	23	73	3	PS00019
Domain	Cl-channel_core	CLCN1 CLCN2	5.33e-04	9	73	2	IPR014743
Domain	-	CLCN1 CLCN2	5.33e-04	9	73	2	1.10.3080.10
Domain	Voltage_CLC	CLCN1 CLCN2	5.33e-04	9	73	2	PF00654
Domain	Cl-channel_volt-gated	CLCN1 CLCN2	5.33e-04	9	73	2	IPR001807
Domain	CH	SPTBN5 FLNC MACF1	2.10e-03	65	73	3	SM00033
Domain	CH	SPTBN5 FLNC MACF1	2.60e-03	70	73	3	PF00307
Domain	-	SPTBN5 FLNC MACF1	2.71e-03	71	73	3	1.10.418.10
Domain	CBS_dom	CLCN1 CLCN2	2.74e-03	20	73	2	IPR000644
Domain	CBS	CLCN1 CLCN2	2.74e-03	20	73	2	PF00571
Domain	CBS	CLCN1 CLCN2	2.74e-03	20	73	2	PS51371
Domain	TPR-contain_dom	NAA25 RPAP3 CEP70 KLC1	2.83e-03	150	73	4	IPR013026
Domain	DEAD/DEAH_box_helicase_dom	TDRD9 ASCC3 DICER1	2.93e-03	73	73	3	IPR011545
Domain	CH	SPTBN5 FLNC MACF1	2.93e-03	73	73	3	PS50021
Domain	DEAD	TDRD9 ASCC3 DICER1	2.93e-03	73	73	3	PF00270
Domain	CH-domain	SPTBN5 FLNC MACF1	3.16e-03	75	73	3	IPR001715
Domain	Spectrin	SPTBN5 MACF1	3.61e-03	23	73	2	PF00435
Domain	TPR_REGION	NAA25 RPAP3 CEP70 KLC1	3.98e-03	165	73	4	PS50293
Domain	TPR	NAA25 RPAP3 CEP70 KLC1	3.98e-03	165	73	4	PS50005
Domain	ARM-like	GPRASP1 MROH1 CEP70 TRRAP WDFY4	4.11e-03	270	73	5	IPR011989
Domain	FYVE	WDFY2 WDFY1	5.71e-03	29	73	2	PF01363
Domain	FYVE	WDFY2 WDFY1	5.71e-03	29	73	2	SM00064
Domain	Spectrin_repeat	SPTBN5 MACF1	5.71e-03	29	73	2	IPR002017
Domain	FHA_DOMAIN	PHLDB1 MDC1	6.51e-03	31	73	2	PS50006
Domain	FHA	PHLDB1 MDC1	6.51e-03	31	73	2	PF00498
Domain	Spectrin/alpha-actinin	SPTBN5 MACF1	6.93e-03	32	73	2	IPR018159
Domain	SPEC	SPTBN5 MACF1	6.93e-03	32	73	2	SM00150
Domain	Znf_FYVE-rel	WDFY2 WDFY1	7.80e-03	34	73	2	IPR017455
Pathway	WP_10Q1121Q1123_COPY_NUMBER_VARIATION_SYNDROME	ERCC5 UVSSA SMARCB1 WDFY4	7.35e-05	61	52	4	M48077
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLII FLNC EEF1D PHLDB1 SLC12A2 RPAP1 CCN1 PDLIM7 MDC1 SHMT2 MACF1 ASCC3 TRRAP DICER1	2.97e-08	1024	74	14	24711643
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	MACF1 TRRAP DICER1 KLC1	8.34e-07	34	74	4	25925205
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLII NCOR2 FLNC EEF1D PHLDB1 INCENP RPAP3 PDLIM7 MDC1 SHMT2 MACF1 POGZ ASCC3 TRRAP	8.73e-07	1353	74	14	29467282
Pubmed	Quantitative study of the interactome of PKCζ involved in the EGF-induced tumor cell chemotaxis.	FLNC EEF1D CEP152 MRPL46 TRRAP DICER1	2.78e-06	184	74	6	23402259
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLII NCOR2 FLNC PHLDB1 LATS2 MROH1 RPAP1 SNX15 MRPL46 MAPKAPK5 TRRAP TEX19	3.56e-06	1105	74	12	35748872
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	NCOR2 SLC12A2 ARHGAP31 PDLIM7 ARHGEF5 MDC1 SCN10A KLC1	3.78e-06	430	74	8	35044719
Pubmed	The AcB/BcA recombinant congenic strains of mice: strategies for phenotype dissection, mapping and cloning of quantitative trait genes.	NAIP APOA1	4.47e-06	2	74	2	17534071
Pubmed	Analysis of WDFY4 rs7097397 and PHLDB1 rs7389 polymorphisms in Chinese patients with systemic lupus erythematosus.	PHLDB1 WDFY4	4.47e-06	2	74	2	35188604
Pubmed	Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds.	SCN10A DICER1	4.47e-06	2	74	2	20702715
Pubmed	Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.	NCOR2 EEF1D SHMT2 MACF1 NCOA4	9.88e-06	133	74	5	15604093
Pubmed	Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism.	CLCN2 SLC12A2	1.34e-05	3	74	2	31615979
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	FLII RNF214 FLNC RPAP3 PDLIM7 MACF1 POGZ ASCC3 DICER1	2.31e-05	724	74	9	36232890
Pubmed	MicroRNAs are mediators of androgen action in prostate and muscle.	NCOR2 DICER1	2.67e-05	4	74	2	21048966
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	EEF1D INCENP NAIP MACF1 ASCC3 USP21	3.08e-05	281	74	6	24163370
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	TTBK2 STOX2 CCN1 INCENP PDLIM7 SMARCB1 APOA1 CEP152 POGZ SLX4 KNL1	3.18e-05	1155	74	11	20360068
Pubmed	Genome-wide searching of rare genetic variants in WTCCC data.	NAA25 TDRD9 POFUT2	4.39e-05	32	74	3	20549515
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	RNF121 RNF214 NCOR2 EEF1D MROH1 SH3BGRL SHMT2 CEP152 ASCC3 MRPL46 POFUT2	5.03e-05	1215	74	11	15146197
Pubmed	Expression of CLCN voltage-gated chloride channel genes in human blood vessels.	CLCN1 CLCN2	6.66e-05	6	74	2	10198195
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNC INCENP MDC1 MACF1 POGZ ASCC3 TRRAP DICER1	7.50e-05	653	74	8	22586326
Pubmed	Orphan quality control shapes network dynamics and gene expression.	RPAP3 SMARCB1 KNL1	8.00e-05	39	74	3	37478862
Pubmed	Identification of in vivo roles of ErbB4-JMa and its direct nuclear signaling using a novel isoform-specific knock out mouse.	CRYM WDFY1	9.31e-05	7	74	2	36241655
Pubmed	Genetic determinants of weight of fast- and slow-twitch skeletal muscle in 500-day-old mice of the C57BL/6J and DBA/2J lineage.	CLCN1 USP21	9.31e-05	7	74	2	15687484
Pubmed	Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.	CLCN1 CLCN2	1.24e-04	8	74	2	27580824
Pubmed	Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.	CLCN2 SLC12A2	1.24e-04	8	74	2	11395011
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	FLII EEF1D RPAP1 SMARCB1 SHMT2 ASCC3 TRRAP KLC1	1.26e-04	704	74	8	29955894
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	NCOR2 ERCC5 LATS2 INCENP MAPKAPK5 TRRAP DICER1 KLC1 KNL1	1.33e-04	910	74	9	36736316
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	FLII FLNC RPAP3 SHMT2 KNL1	1.40e-04	232	74	5	25515538
Pubmed	Next-generation sequencing to generate interactome datasets.	EEF1D FCHSD2 GOLPH3L PDLIM7 ARHGEF5 TMEM115 CEP70 SHMT2 SNX15 SLX4	1.55e-04	1147	74	10	21516116
Pubmed	Comparative mapping of the actin-binding protein 280 genes in human and mouse.	FLNC CLCN1	1.59e-04	9	74	2	8088838
Pubmed	Changing expression of chloride channels during preimplantation mouse development.	CLCN1 CLCN2	1.59e-04	9	74	2	23115349
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	RPAP3 PDLIM7 MDC1 POGZ ASCC3 TRRAP KLC1	1.70e-04	549	74	7	38280479
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	NCOR2 EEF1D ZNF845 INCENP CCDC174 MDC1 POGZ SLX4 KNL1	1.90e-04	954	74	9	36373674
Pubmed	Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma.	ERCC5 KLC1	1.99e-04	10	74	2	20601096
Pubmed	Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells.	NCOR2 TRRAP	1.99e-04	10	74	2	12738788
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	FLII NCOR2 NAA25 PCLO SHMT2 POGZ	2.08e-04	398	74	6	35016035
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1F CLCN1 CLCN2 SCN10A	2.26e-04	139	74	4	16985003
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FCHSD2 PHLDB1 MROH1 RPAP1 MACF1 POGZ	2.34e-04	407	74	6	12693553
Pubmed	Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.	FLNC TRRAP	2.43e-04	11	74	2	24349473
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	STOX2 LATS2 SLC12A2 PDLIM7 MACF1	2.51e-04	263	74	5	34702444
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	NCOR2 RPAP3 POGZ ASCC3 KLC1 KNL1	2.70e-04	418	74	6	34709266
Pubmed	MicroRNAs are essential for development and function of inner ear hair cells in vertebrates.	SLC12A2 DICER1	2.91e-04	12	74	2	19416898
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	FLII RNF214 EEF1D PDLIM7 MACF1 POGZ ASCC3	2.94e-04	601	74	7	33658012
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF845 INCENP ARHGEF5 MDC1 SMARCB1 POGZ TRRAP	3.15e-04	608	74	7	36089195
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	STOX2 RPAP1 DISP3 WDFY1	3.26e-04	153	74	4	10718198
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	CCN1 SMARCB1 MACF1 ASCC3 KNL1	3.45e-04	282	74	5	23667531
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	NAA25 LATS2 SHMT2 NCOA4 DICER1	3.80e-04	288	74	5	38496616
Pubmed	DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.	LATS2 CCN1	4.00e-04	14	74	2	28087714
Pubmed	Mapping the Genetic Landscape of Human Cells.	NAA25 CEP152 ASCC3 MRPL46 TRRAP DICER1	4.05e-04	451	74	6	30033366
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TTBK2 ERCC5 SHMT2 MACF1 NCOA4 WDFY4 ZNF568 SLX4 WDFY1	4.83e-04	1084	74	9	11544199
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	PHLDB1 LATS2 RPAP1 TRRAP WDFY1	5.01e-04	306	74	5	18973680
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	FLII EEF1D RPAP1 RPAP3 SMARCB1 ASCC3 MRPL46 ZNF333 TRRAP DICER1	5.17e-04	1335	74	10	29229926
Pubmed	A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1.	NCOR2 SMARCB1	5.26e-04	16	74	2	11013263
Pubmed	Primary Autosomal Recessive Microcephalies and Seckel Syndrome Spectrum Disorders – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	CEP152 KNL1	5.26e-04	16	74	2	20301772
Pubmed	Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.	MDC1 SLX4	5.26e-04	16	74	2	27760317
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	FLNC MACF1 TRRAP	5.81e-04	76	74	3	27542412
Pubmed	Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate.	LATS2 CCN1	5.95e-04	17	74	2	32243503
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	NCOR2 SMARCB1 POGZ	6.27e-04	78	74	3	28611094
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	NCOR2 CCN1 ARHGAP31 CEP152	6.54e-04	184	74	4	32908313
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	SPTBN5 SLC12A2 PCLO MACF1 APOA1 TEX19	6.67e-04	496	74	6	31343991
Pubmed	Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.	SLC12A2 KLC1	6.68e-04	18	74	2	31910261
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTBN5 FLNC	6.68e-04	18	74	2	12119179
Pubmed	Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.	FLII FLNC EEF1D MACF1	7.51e-04	191	74	4	33762435
Pubmed	Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.	INCENP POGZ ZNF568	7.52e-04	83	74	3	20562864
Pubmed	An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.	PNMA5 PDLIM7 CEP70 SHMT2 POGZ SLX4	8.02e-04	514	74	6	29892012
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	FLII MDC1 CEP152 POGZ ASCC3	8.04e-04	340	74	5	29478914
Pubmed	T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.	NCOR2 NCOA4	8.28e-04	20	74	2	11877444
Pubmed	Human transcription factor protein interaction networks.	RNF214 NCOR2 EEF1D CCDC174 MDC1 SMARCB1 CEP152 POGZ TRRAP SLX4	8.73e-04	1429	74	10	35140242
Pubmed	Interaction network of human early embryonic transcription factors.	NCOR2 MDC1 SMARCB1 POGZ SLX4	9.27e-04	351	74	5	38297188
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	STOX2 ARHGAP31 UVSSA MDC1 POGZ DICER1	9.30e-04	529	74	6	14621295
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	SLC12A2 RPAP3 CCDC174 MDC1 NCOA4 DICER1 KNL1	9.51e-04	733	74	7	34672954
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	FLII NAA25 MDC1 SMARCB1 POGZ TRRAP	9.67e-04	533	74	6	30554943
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	NCOR2 NAA25 CEP152 POFUT2 DICER1 WDFY1	9.95e-04	536	74	6	15840001
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	INCENP MDC1 POGZ ASCC3 SLX4	1.00e-03	357	74	5	37059091
Pubmed	Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney.	CRYM SLC12A2	1.00e-03	22	74	2	29449449
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	NCOR2 FLNC EEF1D ZNF845 NAA25 SLC12A2 PDLIM7 POGZ SLX4	1.01e-03	1203	74	9	29180619
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	NCOR2 NAA25 CEP152 POFUT2 DICER1 WDFY1	1.01e-03	538	74	6	10512203
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	MACF1 CEP152 ASCC3 DICER1	1.05e-03	209	74	4	36779422
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	RPAP3 PDLIM7 ASCC3 KLC1	1.19e-03	216	74	4	31519766
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	NCOR2 FLNC EEF1D INCENP PDLIM7 MDC1 SHMT2 KNL1	1.19e-03	989	74	8	36424410
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	STOX2 PHLDB1 PCLO WDFY1	1.23e-03	218	74	4	33378226
Pubmed	The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.	GOLPH3L TMEM115 SMARCB1 ZNF333	1.27e-03	220	74	4	24705354
Pubmed	PIDD orchestrates translesion DNA synthesis in response to UV irradiation.	ERCC5 RPAP3	1.30e-03	25	74	2	21415862
Pubmed	Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade.	LATS2 CCN1	1.30e-03	25	74	2	30912742
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FLII NCOR2 ERCC5 RPAP1 MDC1 POGZ TRRAP	1.30e-03	774	74	7	15302935
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	GPRASP1 FLNC SHMT2 ASCC3 TRRAP POFUT2 DICER1 USP21	1.32e-03	1005	74	8	19615732
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	FLNC EEF1D SLC12A2 PDLIM7 TMEM115 KLC1	1.34e-03	568	74	6	37774976
Pubmed	Proteomic characterization of the human centrosome by protein correlation profiling.	CEP70 CEP152	1.40e-03	26	74	2	14654843
Pubmed	Profiling the interactome of protein kinase C ζ by proteomics and bioinformatics.	FLNC EEF1D MRPL46	1.48e-03	105	74	3	29491746
Pubmed	Lats1 and Lats2 are required for the maintenance of multipotency in the Müllerian duct mesenchyme.	LATS2 CCN1	1.51e-03	27	74	2	31575647
Pubmed	NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.	NCOR2 TRRAP	1.51e-03	27	74	2	23395962
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	MDC1 POGZ SLX4	1.52e-03	106	74	3	19394292
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	CACNA1F CLCN2 MACF1 DICER1	1.56e-03	233	74	4	32290105
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	MROH1 ZNF333 SLX4	1.57e-03	107	74	3	11347906
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	GPRASP1 FLII NAA25 CCN1 CEP70 ZNF202 MACF1 POGZ SLX4	1.60e-03	1285	74	9	35914814
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	FLNC PDLIM7 SH3BGRL MACF1	1.61e-03	235	74	4	28378594
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	FLNC EEF1D FCHSD2 TRRAP	1.61e-03	235	74	4	30258100
Pubmed	A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth.	LATS2 CCN1	1.63e-03	28	74	2	25912685
Pubmed	Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.	NCOR2 CCN1	1.63e-03	28	74	2	24880616
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	NCOR2 FLNC EEF1D MDC1 KLC1	1.63e-03	399	74	5	35987950
Pubmed	Functional proteomics mapping of a human signaling pathway.	NCOR2 FLNC PDLIM7 MACF1 ASCC3 KNL1	1.64e-03	591	74	6	15231748
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	SPTBN5 TTBK2 RPAP1 KNL1	9.75e-05	147	74	4	chr15q15
Cytoband	7q35	ARHGEF35 CLCN1 ARHGEF5	9.93e-05	55	74	3	7q35
Cytoband	11q23.3	RNF214 PHLDB1 ZNF202	2.80e-04	78	74	3	11q23.3
Cytoband	12q24.13	NAA25 MAPKAPK5	7.51e-04	25	74	2	12q24.13
Cytoband	15q14	TMCO5A KNL1	2.87e-03	49	74	2	15q14
GeneFamily	Chloride voltage-gated channels	CLCN1 CLCN2	3.46e-04	10	51	2	302
GeneFamily	X-linked mental retardation\|RNA helicases	ASCC3 DICER1	4.22e-04	11	51	2	1168
Coexpression	GSE14415_ACT_VS_CTRL_NATURAL_TREG_DN	TTBK2 EEF1D FCHSD2 SLC12A2 RPAP3 MDC1 MFSD6	4.48e-07	168	73	7	M2962
Coexpression	HARALAMBIEVA_PBMC_FLUARIX_AGE_50_74YO_CORR_WITH_28D_MEM_B_CELL_RESPONSE_AT_28DY_POSITIVE	FLII NCOR2 FCHSD2 ERCC5 LATS2 MROH1 INCENP PDLIM7 UVSSA SMARCB1 NCOA4 WDFY4 DICER1 SLX4	7.73e-06	1250	73	14	M41099
Coexpression	HARALAMBIEVA_PBMC_FLUARIX_AGE_50_74YO_CORR_WITH_28D_MEM_B_CELL_RESPONSE_AT_0DY_NEGATIVE	NCOR2 FCHSD2 ERCC5 MROH1 INCENP SMARCB1 MACF1 WDFY4	2.83e-05	435	73	8	M41115
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet-Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRYM SLC12A2 MROH1 GOLPH3L MFSD6 SNX15	5.05e-07	177	74	6	e1e45956887371b1c18f1eb479dd930031497520
Computational	Actin cytoskeleton binding.	FLII FLNC MACF1	1.68e-04	30	39	3	MODULE_524
Computational	Genes in the cancer module 419.	FLII FLNC MACF1	2.44e-04	34	39	3	MODULE_419
Disease	myopathy (implicated_via_orthology)	FLNC CLCN1 CLCN2 PDLIM7	5.85e-06	48	72	4	DOID:423 (implicated_via_orthology)
Disease	MICROCEPHALY 4, PRIMARY, AUTOSOMAL RECESSIVE	CEP152 KNL1	5.87e-06	2	72	2	C1858516
Disease	smoking status measurement, ulcerative colitis	MAPKAPK5 WDFY4	4.50e-04	13	72	2	EFO_0000729, EFO_0006527
Disease	Autosomal recessive primary microcephaly	CEP152 KNL1	6.04e-04	15	72	2	cv:C3711387
Disease	proprotein convertase subtilisin/kexin type 7 measurement	RNF214 APOA1	7.80e-04	17	72	2	EFO_0008270
Disease	calcium measurement	EEF1D ERCC5 SLC12A2 MFSD6 MACF1 PDCL2 ASCC3	8.52e-04	628	72	7	EFO_0004838
Disease	dilated cardiomyopathy	FLNC SMARCB1	1.08e-03	20	72	2	EFO_0000407
Disease	Primary microcephaly	CEP152 KNL1	1.31e-03	22	72	2	C0431350
Disease	Autosomal Recessive Primary Microcephaly	CEP152 KNL1	1.31e-03	22	72	2	C3711387
Disease	prostate carcinoma, breast carcinoma, ovarian carcinoma	INCENP ARHGEF5	1.98e-03	27	72	2	EFO_0000305, EFO_0001075, EFO_0001663
Disease	ganglion cell inner plexiform layer thickness measurement	STOX2 TDRD9	2.13e-03	28	72	2	EFO_0600005

Protein segments in the cluster

Peptide	Gene	Start	Entry
DEEWEKENRTTMERE	TMCO5A	61	Q8N6Q1
PMNEWERNLAEKEDN	NAIP	956	Q13075
MDTEDDPLLQDVWLE	DISP3	1	Q9P2K9
VENADPEWKKRNMAE	CEP152	1106	O94986
NDGEWEQEDMERKAQ	ARHGEF5	301	Q12774
WVCDEDSIKDPMEDQ	CCN1	161	O00622
NDGEWEQEDMERKAQ	ARHGEF35	301	A5YM69
WDNLEKETEGLRQEM	APOA1	96	P02647
DEEEESLMWRAPKEE	DICER1	1421	Q9UPY3
DVKPWDDETDMAQLE	EEF1D	201	P29692
PDWRELDDELMKEAV	CRYM	231	Q14894
DSDPEMWELLQREKD	SHMT2	51	P34897
DWITQAEELDMEDPS	CACNA1F	406	O60840
MEAWEKKVERIENNP	NCOR2	306	Q9Y618
AEAEQLMEEWNEDLD	FLII	891	Q13045
ESQPAIWNRDAEEDM	MDC1	421	Q14676
PEEEWSQISEMAKDV	MAPKAPK5	266	Q8IW41
MDNKDLVWLEEIQEE	INCENP	26	Q9NQS7
VRQDSMEPSDLWDDV	LATS2	831	Q9NRM7
SVQTDDEDQDEWDMP	PCLO	3471	Q9Y6V0
MQDPNEDTEWNDILR	PDCL2	1	Q8N4E4
PMWEDEDDEDARKQT	FLNC	146	Q14315
EEDDDTEEAWMQLRP	CYB5RL	6	Q6IPT4
EKNNPVEEWDSEMRA	KNL1	2066	Q8NG31
QWLAVPDEEEDKTML	MFSD6	621	Q6ZSS7
ETLPQEEWEEKLLMF	MROH1	596	Q8NDA8
EDSDSEPLWKQREDM	MEIOSIN	466	C9JSJ3
PDASKQRLMENTEDW	PDLIM7	141	Q9NR12
PEVRKSIDEMNNAWE	MACF1	6081	Q9UPN3
QELPDQDEMDLSDWL	NCOA4	291	Q13772
QDEMDLSDWLVTPQE	NCOA4	296	Q13772
DRLMTEKQQEEAEWE	CEP70	16	Q8NHQ1
MESEEDSNWEKSPDN	GOLPH3L	21	Q9H4A5
QQWEEEEREALKRPM	CCDC174	216	Q6PII3
NQVMEELENERWARP	FCHSD2	411	O94868
DENKPIWMHAEEREE	KLC1	421	Q07866
VSKPEDDEEMIVESW	GPRASP1	926	Q5JY77
EQDILLAQDLEDMWE	MRPL46	111	Q9H2W6
KQERPEWQDPELMRD	UVSSA	616	Q2YD98
EWQDPELMRDVEAAT	UVSSA	621	Q2YD98
EWNQVDPKLVMEQAD	TDRD9	1346	Q8NDG6
TDDADRIPFQEDWMK	POFUT2	261	Q9Y2G5
LFMECEEEELEPWQK	POGZ	6	Q7Z3K3
SSEEEDEKEWQERMN	ERCC5	156	P28715
ANEENRKWMRENVPE	SH3BGRL	41	O75368
VDQFEWDMSEKENSP	SMARCB1	276	Q12824
DADEEMAWVQEKLPL	SPTBN5	2901	Q9NRC6
VQKQWDKVEEMEPLE	SLX4	896	Q8IY92
TEEDPKQWLNMDERE	ASCC3	1581	Q8N3C0
TDLVDNMSPEEIEAW	CLCN1	791	P35523
MSPEEILEWEEQQLD	CLCN2	766	P51788
WKEDERNSHEAPMTE	ZNF845	101	Q96IR2
EDAKEMPLTWVQDEI	ZNF572	66	Q7Z3I7
RDEEEWENTEAVMKN	PNMA5	326	Q96PV4
EVWEMELDRLKNQDG	RNF214	321	Q8ND24
EPELSDDDRANLMWK	USP21	346	Q9UK80
MDVERQETPEWLDSD	WDFY2	271	Q96P53
DLTQEEWEQMKPAQR	ZNF568	56	Q3ZCX4
LQDFMRDLENWEKDI	RPAP3	21	Q9H6T3
AVDSREVNMQPKWED	SCN10A	1376	Q9Y5Y9
EEEKNREDVGTMQWL	STOX2	791	Q9P2F5
MKEDEPWRITDNELE	SLC12A2	1126	P55011
KRVEDQSIWPSMDDD	TMEM115	296	Q12893
RPQEKDVWEEMDANK	TTBK2	376	Q6IQ55
TMEVESARLDQEPWE	SNX15	236	Q9NRS6
FKQWPDLEERMDEGD	WDFY4	811	Q6ZS81
EVDMSDLSPEEQWRV	RNF121	21	Q9H920
EMDEDDLANALIWPE	ARHGAP31	641	Q2M1Z3
WESMERSDEENLKEE	PHLDB1	676	Q86UU1
CPEDWLQDMQRLSEE	RPAP1	816	Q9BWH6
DPAWLQEDKVEEEAM	ZNF333	176	Q96JL9
MATAVEPEDQDLWEE	ZNF202	1	O95125
WELQRIKDQQPDSDM	TRRAP	2016	Q9Y4A5
SEDWEEDNWDPELME	TEX19	51	Q8NA77
MDVSREEAPQWLESD	WDFY1	271	Q8IWB7
KSMNLRPEEDDIPWE	NAA25	636	Q14CX7