Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	abnormal potassium level	GAK EXPH5 TNIP1 REN CHD7 ACE ADCY6	1.40e-05	196	57	7	MP:0020887
MousePheno	abnormal potassium ion homeostasis	GAK EXPH5 TNIP1 REN CHD7 ACE ADCY6	1.49e-05	198	57	7	MP:0011978
MousePheno	abnormal ion homeostasis	SLC6A6 ASXL1 GAK PIK3CD EXPH5 CPEB3 GIGYF2 TNIP1 REN CHD7 ACE ALK ARPC1B ADCY6 UNC80 CFB	2.15e-05	1232	57	16	MP:0001765
MousePheno	increased fluid intake	AFMID REN ACE ALK ADCY6	6.37e-05	104	57	5	MP:0011941
MousePheno	abnormal hemoglobin	GPALPP1 AFMID ASXL1 GAK ABCA4 WDR33 HLA-E GIGYF2 TNIP1 CHD7 KATNAL1 ARPC1B CFB	8.62e-05	946	57	13	MP:0001588
MousePheno	abnormal nucleolus morphology	NEPRO POLR1B	9.75e-05	4	57	2	MP:0008830
MousePheno	decreased circulating angiotensin II level	REN ACE	9.75e-05	4	57	2	MP:0031231
MousePheno	decreased angiotensin II level	REN ACE	9.75e-05	4	57	2	MP:0031228
MousePheno	abnormal vestibulocochlear nerve morphology	OTOF NTRK3 CHD7	1.07e-04	23	57	3	MP:0001072
MousePheno	vitreal fibroplasia	RPGRIP1 VPS13B	1.62e-04	5	57	2	MP:0003381
MousePheno	abnormal fluid intake	AFMID REN ACE ALK ADCY6	2.26e-04	136	57	5	MP:0011947
MousePheno	atrioventricular cushion hypoplasia	CHD7 ECE1	2.42e-04	6	57	2	MP:0030992
Domain	Anion_exchange_CS	SLC4A3 SLC4A2	3.46e-05	3	64	2	IPR018241
Domain	Anion_exchange	SLC4A3 SLC4A2	1.15e-04	5	64	2	IPR001717
Domain	ANION_EXCHANGER_2	SLC4A3 SLC4A2	2.40e-04	7	64	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A3 SLC4A2	2.40e-04	7	64	2	PS00219
Domain	Band3_cytoplasmic_dom	SLC4A3 SLC4A2	4.10e-04	9	64	2	IPR013769
Domain	Band_3_cyto	SLC4A3 SLC4A2	4.10e-04	9	64	2	PF07565
Domain	-	SLC4A3 SLC4A2	4.10e-04	9	64	2	3.40.1100.10
Domain	HCO3_cotransp	SLC4A3 SLC4A2	5.11e-04	10	64	2	PF00955
Domain	HCO3_transpt_C	SLC4A3 SLC4A2	5.11e-04	10	64	2	IPR011531
Domain	PTrfase/Anion_transptr	SLC4A3 SLC4A2	5.11e-04	10	64	2	IPR016152
Domain	HCO3_transpt_euk	SLC4A3 SLC4A2	5.11e-04	10	64	2	IPR003020
Domain	Tyr_kinase_rcpt_2_CS	NTRK3 ALK	6.23e-04	11	64	2	IPR002011
Domain	RECEPTOR_TYR_KIN_II	NTRK3 ALK	7.46e-04	12	64	2	PS00239
Domain	ABC_A	ABCA4 ABCA12	7.46e-04	12	64	2	IPR026082
Domain	C2_dom	RPGRIP1 GAK OTOF PIK3CD	2.42e-03	164	64	4	IPR000008
Domain	VWF_A	VWA5B2 HMCN1 CFB	4.76e-03	99	64	3	IPR002035
Domain	ABC_transporter_CS	ABCA4 ABCA12	9.11e-03	42	64	2	IPR017871
Pathway	WP_CONVERSION_OF_ANGIOTENSINOGEN_TO_ANGIOTENSIN_II	REN ACE	1.18e-04	5	49	2	M45547
Pathway	WP_SARSCOV2_AND_ACE2_RECEPTOR_MOLECULAR_MECHANISMS	REN ACE	2.46e-04	7	49	2	M39867
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	PIK3CD ALK	3.27e-04	8	49	2	M47405
Pathway	WP_ACE_INHIBITOR_PATHWAY	REN ACE	3.27e-04	8	49	2	MM15876
Pathway	WP_NONCLASSICAL_ROLE_OF_VITAMIN_D	REN ACE	3.27e-04	8	49	2	M42566
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ASXL1 SULF2 GIGYF2 TNIP1 CHD7 ADCY6 UNC80	2.70e-07	225	67	7	12168954
Pubmed	Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.	RPGRIP1 BEST1 ABCA4 CFB CRB1	7.45e-07	87	67	5	20801516
Pubmed	Circulating and local bone marrow renin-angiotensin system in leukemic hematopoiesis: preliminary evidences.	REN ACE	3.66e-06	2	67	2	12186695
Pubmed	Molecular analysis of ABCA4 and CRB1 genes in a Spanish family segregating both Stargardt disease and autosomal recessive retinitis pigmentosa.	ABCA4 CRB1	3.66e-06	2	67	2	18334942
Pubmed	Genetic heterogeneity and clinical outcome in a Swedish family with retinal degeneration caused by mutations in CRB1 and ABCA4 genes.	ABCA4 CRB1	3.66e-06	2	67	2	24664696
Pubmed	Studying the correlation of renin-angiotensin-system (RAS) components and insulin resistance in polycystic ovary syndrome (PCOs).	REN ACE	3.66e-06	2	67	2	23461768
Pubmed	Endothelin-converting enzyme: ultrastructural localization and its recycling from the cell surface.	ECE1 ACE	3.66e-06	2	67	2	9449382
Pubmed	Novel mutations in CRB1 and ABCA4 genes cause Leber congenital amaurosis and Stargardt disease in a Swedish family.	ABCA4 CRB1	3.66e-06	2	67	2	23443024
Pubmed	Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization.	SLC4A3 SLC4A2	3.66e-06	2	67	2	11248201
Pubmed	Association between plasma activities of semicarbazide-sensitive amine oxidase and angiotensin-converting enzyme in patients with type 1 diabetes mellitus.	AOC3 ACE	3.66e-06	2	67	2	15830186
Pubmed	cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger.	SLC4A3 SLC4A2	3.66e-06	2	67	2	2294114
Pubmed	An unusual fusion gene EML4-ALK in a patient with congenital mesoblastic nephroma.	NTRK3 ALK	1.10e-05	3	67	2	34378283
Pubmed	PPARgamma-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of cAMP on renin gene expression.	REN ADCY6	1.10e-05	3	67	2	20861226
Pubmed	Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex.	SLC4A3 SLC4A2	1.10e-05	3	67	2	11208611
Pubmed	Clinical and genetic investigations of three Moroccan families with retinitis pigmentosa phenotypes.	ABCA4 CRB1	1.10e-05	3	67	2	33633436
Pubmed	Molecular genetics with clinical characteristics of Leber congenital amaurosis in the Han population of western China.	RPGRIP1 CRB1	1.10e-05	3	67	2	33970760
Pubmed	Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).	ECE1 ACE	1.10e-05	3	67	2	11906289
Pubmed	Genetic analysis of indel markers in three loci associated with Parkinson's disease.	GIGYF2 ACE	1.10e-05	3	67	2	28873462
Pubmed	Alterations in the 'local umbilical cord blood renin-angiotensin system' during pre-eclampsia.	REN ACE	1.10e-05	3	67	2	17851801
Pubmed	Expression and function of bicarbonate/chloride exchangers in the preimplantation mouse embryo.	SLC4A3 SLC4A2	1.10e-05	3	67	2	7592657
Pubmed	Renin angiotensin system in development of mice and men.	REN ACE	1.10e-05	3	67	2	8952516
Pubmed	Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo.	ABCA4 CRB1	1.10e-05	3	67	2	27992460
Pubmed	Transgenic animal models for the functional analysis of vasoactive peptides.	REN ACE	1.10e-05	3	67	2	9876285
Pubmed	Effects of imatinib mesylate on renin-angiotensin system (RAS) activity during the clinical course of chronic myeloid leukaemia.	REN ACE	1.10e-05	3	67	2	19761684
Pubmed	Clinical and molecular findings in a cohort of 152 Brazilian severe early onset inherited retinal dystrophy patients.	RPGRIP1 CRB1	1.10e-05	3	67	2	32865313
Pubmed	Relationship between the renin-angiotensin system genes and diabetic nephropathy in the Chinese.	REN ACE	2.19e-05	4	67	2	11776100
Pubmed	Genetic polymorphisms in the Renin-Angiotensin system in high-altitude and low-altitude Native American populations.	REN ACE	2.19e-05	4	67	2	12556231
Pubmed	Nkx2.5 regulates endothelin converting enzyme-1 during pharyngeal arch patterning.	ECE1 HAND2	2.19e-05	4	67	2	28109039
Pubmed	Polymorphisms of renin-angiotensin system and natriuretic peptide receptor A genes in patients of Greek origin with a history of myocardial infarction.	REN ACE	2.19e-05	4	67	2	20529973
Pubmed	Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.	REN ACE	2.19e-05	4	67	2	16116425
Pubmed	A Report on Molecular Diagnostic Testing for Inherited Retinal Dystrophies by Targeted Genetic Analyses.	BEST1 ABCA4	2.19e-05	4	67	2	28005406
Pubmed	Fundus autofluorescence and photoreceptor cell rosettes in mouse models.	ABCA4 CRB1	2.19e-05	4	67	2	25015357
Pubmed	Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine.	SLC4A3 SLC4A2	2.19e-05	4	67	2	11842009
Pubmed	Associations between hypertension and genes in the renin-angiotensin system.	REN ACE	2.19e-05	4	67	2	12695419
Pubmed	ETV6-NTRK3 and STRN-ALK kinase fusions are recurrent events in papillary thyroid cancer of adult population.	NTRK3 ALK	2.19e-05	4	67	2	29046324
Pubmed	Association of renin-angiotensin system and natriuretic peptide receptor A gene polymorphisms with hypertension in a Hellenic population.	REN ACE	2.19e-05	4	67	2	19126660
Pubmed	Renin-angiotensin-aldosterone system gene polymorphisms in coronary artery bypass graft surgery patients.	REN ACE	2.19e-05	4	67	2	20223792
Pubmed	Genetic polymorphisms of the renin-angiotensin system in preterm delivery and premature rupture of membranes.	REN ACE	2.19e-05	4	67	2	18205094
Pubmed	Confirmation that the renin gene distal enhancer polymorphism REN-5312C/T is associated with increased blood pressure.	REN ACE	2.19e-05	4	67	2	20160196
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	THAP4 SDK2 SULF2 GIGYF2 TNIP1 PRRC2A	2.61e-05	302	67	6	30561431
Pubmed	Genetic variant of the Renin-Angiotensin system and diabetes influences blood pressure response to Angiotensin receptor blockers.	REN ACE	3.64e-05	5	67	2	19509012
Pubmed	Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.	ECE1 ACE	3.64e-05	5	67	2	16912050
Pubmed	P-selectin primes leukocyte integrin activation during inflammation.	PIK3CD TNIP1	3.64e-05	5	67	2	17632516
Pubmed	Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms.	REN ACE	3.64e-05	5	67	2	16672053
Pubmed	Combined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon region.	REN ACE	3.64e-05	5	67	2	17546276
Pubmed	Identification of mutations in the AIPL1, CRB1, GUCY2D, RPE65, and RPGRIP1 genes in patients with juvenile retinitis pigmentosa.	RPGRIP1 CRB1	3.64e-05	5	67	2	16272259
Pubmed	Developmental renin expression in mice with a defective renin-angiotensin system.	REN ACE	3.64e-05	5	67	2	19710239
Pubmed	Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice.	ABCA4 CRB1	3.64e-05	5	67	2	32265302
Pubmed	Genetic variation in CYP27B1 is associated with congestive heart failure in patients with hypertension.	REN ACE	3.64e-05	5	67	2	19891555
Pubmed	Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension.	REN ACE	3.64e-05	5	67	2	15662219
Pubmed	Effects of mineralocorticoid receptor gene disruption on the components of the renin-angiotensin system in 8-day-old mice.	REN ACE	3.64e-05	5	67	2	9973259
Pubmed	Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney.	REN ACE	5.46e-05	6	67	2	27649628
Pubmed	Foxd1 is an upstream regulator of the renin-angiotensin system during metanephric kidney development.	REN ACE	5.46e-05	6	67	2	28665931
Pubmed	Genetic determinants of nonmodulating hypertension.	REN ACE	5.46e-05	6	67	2	14530292
Pubmed	[Comparative genetic analysis of different forms of low-renin arterial hypertension].	REN ACE	5.46e-05	6	67	2	18856058
Pubmed	Autophagy protects the retina from light-induced degeneration.	ABCA4 CRB1	7.63e-05	7	67	2	23341467
Pubmed	Genetic polymorphisms in the angiotensin II receptor gene and their association with open-angle glaucoma in a Japanese population.	REN ACE	7.63e-05	7	67	2	15914614
Pubmed	Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules.	HLA-E ACE	7.63e-05	7	67	2	1316930
Pubmed	Angiotensin converting enzyme DD genotype is associated with hypertensive crisis.	REN ACE	7.63e-05	7	67	2	12394950
Pubmed	Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.	REN ACE	7.63e-05	7	67	2	18953568
Pubmed	[Association analysis of the essential hypertension susceptibility genes in adolescents: Kangwha study].	REN ACE	7.63e-05	7	67	2	16615274
Pubmed	Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.	SLC4A3 SLC4A2	1.02e-04	8	67	2	26110920
Pubmed	PFGE mapping and RFLP analysis of the S/D region of the mouse H-2 complex.	PRRC2A CFB	1.02e-04	8	67	2	1351875
Pubmed	Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk.	REN ACE	1.02e-04	8	67	2	19716087
Pubmed	Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells.	REN ACE	1.02e-04	8	67	2	33480126
Pubmed	Chromosomal location of the murine anion exchanger genes encoding AE2 and AE3.	SLC4A3 SLC4A2	1.02e-04	8	67	2	7894173
Pubmed	The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse.	REN ACE	1.02e-04	8	67	2	25249154
Pubmed	Direct effects of T-bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation.	TBX21 HLA-E	1.63e-04	10	67	2	15719366
Pubmed	CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration.	ABCA4 CRB1	1.63e-04	10	67	2	24639355
Pubmed	A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.	TNIP1 CFB	1.99e-04	11	67	2	19838195
Pubmed	Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study.	REN ACE	1.99e-04	11	67	2	20577119
Pubmed	The rationale and design of the PERindopril GENEtic association study (PERGENE): a pharmacogenetic analysis of angiotensin-converting enzyme inhibitor therapy in patients with stable coronary artery disease.	REN ACE	1.99e-04	11	67	2	19082699
Pubmed	Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure.	REN ACE	1.99e-04	11	67	2	20486282
Pubmed	Gene targeting approaches to analyzing hypertension.	REN ACE	1.99e-04	11	67	2	10405217
Pubmed	Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci.	REN SLC4A3	2.38e-04	12	67	2	11161799
Pubmed	Gene-expression profile of collagen-induced arthritis.	SLC6A6 HLA-E	2.38e-04	12	67	2	11908948
Pubmed	A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.	REN ACE	2.81e-04	13	67	2	18483625
Pubmed	A physical map of the mouse H2 Bat5/Db interval.	HLA-E PRRC2A	3.28e-04	14	67	2	9021146
Pubmed	Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss.	ABCA4 CFB	3.28e-04	14	67	2	19015224
Pubmed	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.	PRRC2A BRWD3	3.28e-04	14	67	2	28878358
Pubmed	CD8αα⁺ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity.	TBX21 HLA-E	3.78e-04	15	67	2	25220211
Pubmed	Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action.	PIK3CD HLA-E	3.78e-04	15	67	2	20702582
Pubmed	CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression.	CHD7 HAND2	3.78e-04	15	67	2	37052590
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	GPALPP1 RPGRIP1 WDR33 CTAGE1 SCN4A ECE1 SLC4A3 ADCY6 AKAP8L EEF1A2	4.19e-04	1442	67	10	35575683
Pubmed	No replication of genetic association between candidate polymorphisms and Alzheimer's disease.	ECE1 ACE	4.31e-04	16	67	2	19889475
Pubmed	HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway.	PIK3CD HLA-E	4.31e-04	16	67	2	11289809
Pubmed	Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens development.	NTRK3 ALK	4.88e-04	17	67	2	23136392
Pubmed	Leber Congenital Amaurosis – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	RPGRIP1 CRB1	4.88e-04	17	67	2	20301475
Pubmed	Nonsyndromic Retinitis Pigmentosa Overview	BEST1 ABCA4 CRB1	5.24e-04	81	67	3	20301590
Pubmed	A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.	RPGRIP1 ECE1 CRB1	5.24e-04	81	67	3	16110338
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	AFMID THAP4 ZNF708 BEST1 PTPRG MAN1C1 KATNAL1 VPS13B BRWD3 EEF1A2	5.38e-04	1489	67	10	28611215
Pubmed	Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters.	SLC6A6 BEST1	5.48e-04	18	67	2	31791063
Pubmed	Development of a diagnostic genetic test for simplex and autosomal recessive retinitis pigmentosa.	ABCA4 CRB1	5.48e-04	18	67	2	20591486
Pubmed	HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.	PIK3CD HLA-E	5.48e-04	18	67	2	12526811
Pubmed	Multiple lineage-specific roles of Smad4 during neural crest development.	NTRK3 HAND2	5.48e-04	18	67	2	19361496
Pubmed	Genetic mapping and physical cloning of UVB susceptibility region in mice.	HLA-E PRRC2A	6.12e-04	19	67	2	10469308
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	GAK GIGYF2 PRRC2A EEF1A2	6.36e-04	202	67	4	24639526
Pubmed	CHD7 regulates cardiovascular development through ATP-dependent and -independent activities.	CHD7 HAND2	6.79e-04	20	67	2	33127760
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	THAP4 OTOF SLC4A3 PRRC2A MOAP1 AKAP8L BRWD3 EEF1A2 KLHL4	7.77e-04	1285	67	9	35914814
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	SIAE ABCA12 ECE1 HERC5	7.89e-04	214	67	4	22199357
Interaction	B2M interactions	HMCN1 OTOF HLA-E HERC5 SLC4A2	1.37e-05	92	67	5	int:B2M
Interaction	LGALS1 interactions	SDK2 PTPRG NTRK3 TNIP1 ECE1 ACE ARPC1B SLC4A2	1.40e-05	332	67	8	int:LGALS1
GeneFamily	ATP binding cassette subfamily A	ABCA4 ABCA12	5.17e-04	14	44	2	805
Coexpression	GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_MONOCYTE_DN	RPGRIP1 ASXL1 BEST1 CHKB ALK SLC4A2	1.10e-05	199	66	6	M4997
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 PTPRG ABCA12 UNC80 CRB1	4.32e-06	160	67	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 PTPRG ABCA12 UNC80 CRB1	4.32e-06	160	67	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 SFRP2 ABCA4 UNC80 EEF1A2	7.25e-06	178	67	5	d3cbdec9d75f076e565baca05ede292cca7758a4
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 SFRP2 ABCA4 SLC4A3 EEF1A2	7.45e-06	179	67	5	4135f9e8cd8494cbc189e5210dded84659643fb8
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA12 ALK UNC80 HAND2 EEF1A2	8.30e-06	183	67	5	7e2bac8b005155888ff4b41ef2e1d975dc17abc7
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA12 ALK UNC80 HAND2 EEF1A2	8.98e-06	186	67	5	15f2e5905486e33f6f7b3b3e9758a0559e8c61ee
ToppCell	wk_08-11-Epithelial-PNS-MFNG+_DBH+_neuron\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CHD7 ALK HAND2 CRB1 EEF1A2	9.45e-06	188	67	5	d3d7d21d4fa39ac4106a164652673de1bef8662d
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHD7 ALK MOAP1 HAND2 EEF1A2	9.70e-06	189	67	5	3f5522be3e24dcdb6272f18cee2f239dfdeff9ad
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SDK2 HMCN1 PTPRG MAN1C1 AOC3	1.10e-05	194	67	5	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC6A6 HMCN1 PTPRG ECE1 ACE	1.10e-05	194	67	5	2c78e754cac848fd47172f94e392749eb0ab50d4
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC6A6 HMCN1 PTPRG ECE1 ACE	1.10e-05	194	67	5	92a8e6e3e3f6fd9dacb723b58e7a8b63473e403e
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHD7 ALK MOAP1 HAND2 EEF1A2	1.10e-05	194	67	5	5bd0f739aa75f387cca7c3b2686493ee2d1ee968
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A6 SULF2 PTPRG SCN4A ECE1	1.19e-05	197	67	5	412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell	Parenchymal-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SULF2 HLA-E ECE1 ACE KLHL4	1.24e-05	199	67	5	a4a9a1c2a34b5a8318a55d1211d6c8661ca9793e
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	HMCN1 PTPRG CHD7 ECE1 ACE	1.27e-05	200	67	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	EXPH5 HLA-E AOC3 ACE	5.75e-05	139	67	4	2fdc8f36510aff24abbc79ef2a842db75a85f946
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	EXPH5 HLA-E AOC3 ACE	5.75e-05	139	67	4	5970a654c64e3b54f9d18c102f5b125eec892fc5
ToppCell	TCGA-Adrenal\|World / Sample_Type by Project: Shred V9	VWA5B2 PLCXD3 UNC80 HAND2	6.77e-05	145	67	4	522ad2bc90b8ec326fcbc7b2250b09566efeeca2
ToppCell	Int-URO-Other\|Int-URO / Disease, Lineage and Cell Type	SDK2 ACE ABTB2 CFB	7.93e-05	151	67	4	ea5f25842e621be41a6491c9959d419d9cc7ebd6
ToppCell	Int-URO-Other-RBC\|Int-URO / Disease, Lineage and Cell Type	SDK2 ACE ABTB2 CFB	7.93e-05	151	67	4	0344d482f1c55c9eaa15beb8d6bac1c6cdca21b3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal--glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SFRP2 NTRK3 REN CHKB	8.56e-05	154	67	4	3211f003f4d1735c7cab9b6cc68af3e0bbfba35e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SFRP2 NTRK3 REN CHKB	8.56e-05	154	67	4	c0fe767fc9ab45b2dfa71171f2a673a4a8decbaf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SFRP2 NTRK3 REN CHKB	8.56e-05	154	67	4	4c2a7590791c2255b15dab82c3622f71f9ffd949
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHD7 ALK HAND2 CRB1	1.09e-04	164	67	4	57301178e420983c0cb72178e288a3a0449fdda3
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AOC3 PLCXD3 PIWIL2 SLC4A3	1.17e-04	167	67	4	cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HMCN1 CHD7 ARPC1B HAND2	1.20e-04	168	67	4	af82e07d1eec51fc6530155f37addbce6221885d
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP3_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ALK ARPC1B HAND2 CRB1	1.22e-04	169	67	4	d9c3b22f62b882b8a2ea6fd9cf7afbe6d1775745
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWA5B2 EXPH5 PLCXD3 SLC4A3	1.25e-04	170	67	4	985c2d5962100fab0d95bee39f382ccbe799331e
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-6_VIP_RCN1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SDK2 SULF2 HMCN1 PLCXD3	1.25e-04	170	67	4	17b8c53c69d78d1b343a5f86d4f82896deee1b0d
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHD7 ALK HAND2 CRB1	1.31e-04	172	67	4	bc3ed05fdd94d5e1f19285aea867b1453292baec
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SFRP2 SULF2 ABCA4 CFB	1.31e-04	172	67	4	9a256db817c1af1802203cc88a55d608fb328c63
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 TBX21 UNC80 EEF1A2	1.37e-04	174	67	4	ecdff386d7f0bc57c170a2c1f4deae5ba7e431b5
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	PTPRG PLCXD3 HAND2 KLHL4	1.46e-04	177	67	4	3d955ea938a1d2fb1b6d68d4997fd454bd632dfc
ToppCell	wk_15-18-Epithelial-PNS-Schwann_precursor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CHD7 ALK HAND2 CRB1	1.46e-04	177	67	4	5357359e6c2161a37f39a6b3b78449f5cbc327d1
ToppCell	PCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ALK UNC80 HAND2 CRB1	1.53e-04	179	67	4	df6d2cdc4e204ce1a4628dc71dfbc5e6c6309b2a
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SCN4A HLA-E ARPC1B KLHL4	1.56e-04	180	67	4	97e0dcb7cfbba60a782824c5e23995058609fcd4
ToppCell	droplet-Kidney-nan-18m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTRK3 AOC3 REN SLC4A3	1.56e-04	180	67	4	b6f44fdedc33b7d93b0074e8e9c8cc32009d4c4d
ToppCell	RA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	ZNF708 PTPRG ECE1 ABTB2	1.59e-04	181	67	4	2b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHD7 ALK MOAP1 HAND2	1.59e-04	181	67	4	7f99002a6411117cc2361334c7c9228e20c574b4
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ALK ARPC1B HAND2 CRB1	1.63e-04	182	67	4	b4fc5e4f5d8440a3c9ee0a6fd0da87b43cabc8c6
ToppCell	IIH-Treg-proli_CD4\|IIH / Condition, Cell_class and T cell subcluster	GAK MAN1C1 ACE BRWD3	1.63e-04	182	67	4	5c7d02da9ca2bca49db9832704b6894dfaa08a71
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ALK ARPC1B HAND2 CRB1	1.63e-04	182	67	4	f7f9be9c7ef8da9864d6aefe20043b26e1bb8697
ToppCell	wk_20-22-Mesenchymal-Chondrocyte-Resting_chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CPEB3 CHKB ABTB2 CFB	1.63e-04	182	67	4	03a5a02acd48f0eb210485348bfe0cd21f486215
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAN1C1 CPEB3 SLC4A3 UNC80	1.63e-04	182	67	4	1923932a9c60e9ec33db69ded441210d1fb07bec
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAN1C1 CPEB3 SLC4A3 UNC80	1.63e-04	182	67	4	69ff652f74cc47fbe0bd665ab17c445c5b959dad
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP2 AOC3 REN EEF1A2	1.66e-04	183	67	4	8de4b616a06be03e1cb6ae6a9ce6bf06485629d3
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ALK HAND2 CRB1 EEF1A2	1.66e-04	183	67	4	9dfb398b9995d562864fe688861a831ada0814cd
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 HMCN1 ABCA12 UNC80	1.70e-04	184	67	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 HMCN1 ABCA12 UNC80	1.70e-04	184	67	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 HMCN1 ABCA12 UNC80	1.70e-04	184	67	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Heart-LA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 HMCN1 ECE1 KLHL4	1.73e-04	185	67	4	1ecfca049c0c1110fd1b2256db7cb7abda6afb04
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SDK2 SFRP2 PLCXD3 ALK	1.73e-04	185	67	4	79cff4f3c6ae8e5ea60e8eae082b9275f2679ee9
ToppCell	facs-Heart-LA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 HMCN1 ECE1 KLHL4	1.73e-04	185	67	4	b6df1412b579d40ed5df806f9c54bd1fbb9a1e15
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ALK HAND2 CRB1 EEF1A2	1.73e-04	185	67	4	512f489daeb3b72d4578dc6f4d0ebb5f38d5bbab
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ALK ARPC1B HAND2 CRB1	1.73e-04	185	67	4	a8946379fc066903fe8f4bc9cbf693b7b424a0cd
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-6_VIP_RCN1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SDK2 SULF2 PLCXD3 ABTB2	1.73e-04	185	67	4	538db481c82b02e5d3b8e03b166f754cc936901e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EXPH5 PLCXD3 CHD7 UNC80	1.77e-04	186	67	4	d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCell	wk_15-18-Epithelial-PNS-MFNG+_DBH+_neuron\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ALK HAND2 CRB1 EEF1A2	1.77e-04	186	67	4	72f7427d62d65e37bb0bf99229a1b75df081a128
ToppCell	PCW_07-8.5-Neuronal-Neuronal_postreplicative\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ALK UNC80 HAND2 EEF1A2	1.77e-04	186	67	4	2fdd0a80ad31cf017aafcf5dcf760ebd786b98c1
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 HMCN1 PTPRG ECE1	1.77e-04	186	67	4	a58c9d1567da0961e0e295a156773d2252ee5a1a
ToppCell	(2)_Fibroblasts-(20)_Fibro-1\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	HMCN1 AOC3 ACE CFB	1.77e-04	186	67	4	e93415b59dd89bc8a966dab0e0b65fe215933598
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	HMCN1 GIGYF2 VPS13B BRWD3	1.77e-04	186	67	4	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EXPH5 GIGYF2 CHD7 EEF1A2	1.81e-04	187	67	4	ef3c85c01bc3da408ae288b6e3096ad888a12e63
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EXPH5 PLCXD3 CHD7 UNC80	1.81e-04	187	67	4	1b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 SDK2 ECE1 UNC80	1.84e-04	188	67	4	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	ASK454-Endothelial-Lymphatic\|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq	BEST1 SFRP2 ALDH6A1 HERC5	1.88e-04	189	67	4	316c857dec9383823e09f966bca62d52d933b141
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC6A6 ECE1 ACE ARPC1B	1.88e-04	189	67	4	feedac2751ed770f80bc56fec31662b5b3826f58
ToppCell	COVID-19-Heart-EC_(POSTN)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SULF2 HMCN1 PLCXD3 ECE1	1.88e-04	189	67	4	7346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC6A6 HMCN1 ECE1 ACE	1.88e-04	189	67	4	360f09f46231a83f99d8fa0158b72a38068e1642
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 ECE1 HAND2 KLHL4	1.88e-04	189	67	4	1137583e21d874c201c20581ba1995e2bfa3de59
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC6A6 PTPRG ECE1 ACE	1.88e-04	189	67	4	1e1afa66b32ae752c0a42b02b80f10205464569c
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 ECE1 HAND2 KLHL4	1.92e-04	190	67	4	7068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCell	droplet-Kidney-nan-21m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP2 NTRK3 AOC3 REN	1.92e-04	190	67	4	e04f47705851563515b6a66a2634cf7a574f7bda
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP2 NTRK3 AOC3 REN	1.92e-04	190	67	4	1803b1e7c36285f9eaabc3c6e9a9752c5908db3d
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HMCN1 NTRK3 AOC3 ADCY6	1.92e-04	190	67	4	d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCell	wk_08-11-Epithelial-PNS-Schwann_precursor\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CHD7 ALK HAND2 CRB1	1.92e-04	190	67	4	4a777d8aa19cadd3b61b023772df142421a89113
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP2 NTRK3 AOC3 REN	1.96e-04	191	67	4	8597a8af294f24496c317d995f07eb5dcc25c13c
ToppCell	facs-MAT\|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SULF2 AOC3 PLCXD3 HAND2	1.96e-04	191	67	4	b4fba92f9bd1354a07fedfca7304a3757e6d5beb
ToppCell	P03-Endothelial-large_vessel_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HMCN1 ECE1 ACE ARPC1B	1.96e-04	191	67	4	b680e0c35f1004be36f9f0680ae3c62952e2b607
ToppCell	P07-Endothelial-large_vessel_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC6A6 ECE1 ACE ARPC1B	1.96e-04	191	67	4	d162917816dd2e4767c97447c1cddae9397713ab
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OTOF PIK3CD ALK CRB1	1.96e-04	191	67	4	9c0ee270209b02043393416ecc9a81ddedfbb8b6
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	SULF2 HMCN1 HLA-E ECE1	2.00e-04	192	67	4	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 ECE1 HAND2 KLHL4	2.00e-04	192	67	4	0b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHD7 ALK UNC80 HAND2	2.00e-04	192	67	4	d8f5df2c2a50e567f24ebecc8033ac97ba89d9c5
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP2 NTRK3 AOC3 REN	2.00e-04	192	67	4	3617d2bc7e33d981f3ec349e9962d8d4bd822fbd
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHD7 ALK UNC80 HAND2	2.04e-04	193	67	4	9661ea0ee7273928c7de2a9f49e853595fa77699
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 OTOF SLC4A3 UNC80	2.04e-04	193	67	4	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	RV-10._Endothelium_II\|RV / Chamber and Cluster_Paper	SULF2 HMCN1 HLA-E ECE1	2.04e-04	193	67	4	01c2df9206f1527c578e808978e58196c35e72f5
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HMCN1 PTPRG ECE1 ACE	2.04e-04	193	67	4	ce5c3ab79900aa6f394c894267340167009c6149
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SFRP2 SULF2 NTRK3 KLHL4	2.04e-04	193	67	4	cd45118ced91b10baed3b1068d4673ec99824b86
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HMCN1 PTPRG ECE1 ACE	2.04e-04	193	67	4	634fdd157cd1efeebf6ecc810bc45e138331451a
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 OTOF SLC4A3 UNC80	2.04e-04	193	67	4	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 OTOF SLC4A3 UNC80	2.04e-04	193	67	4	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 ECE1 HAND2 KLHL4	2.08e-04	194	67	4	c5e77650d7abee339ec38fa78a622bb124db3fa5
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ALK MOAP1 HAND2 EEF1A2	2.08e-04	194	67	4	15224fb3e7ca5bd1fb8c41f8275842f737014095
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC6A6 PTPRG ECE1 ACE	2.08e-04	194	67	4	1b382508453c5b08fb617f626b230adf3b6cff99
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	SULF2 HMCN1 HLA-E ECE1	2.08e-04	194	67	4	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HMCN1 PTPRG ECE1 ACE	2.08e-04	194	67	4	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP2 NTRK3 AOC3 REN	2.08e-04	194	67	4	80be44e9ddd9f6ddd9dff7cba0eb457431204c2d
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC6A6 HMCN1 ECE1 ACE	2.08e-04	194	67	4	44c7d4b75f3b7c9301eba20610e548a01a84ae40
Drug	idrapril	AOC3 REN ACE	1.35e-06	8	67	3	CID000065960
Drug	Mexiletine hydrochloride [5370-01-4]; Up 200; 18.6uM; PC3; HT_HG-U133A	PIK3CD NTRK3 TBX21 CPEB3 PIWIL2 ECE1 ALK	1.89e-06	198	67	7	3781_UP
Drug	EXP6803	SIAE REN ACE	2.88e-06	10	67	3	CID000195116
Drug	nsc25485	PIK3CD SCN4A TNIP1 PLCXD3 REN CHKB ACE ADCY6	3.68e-06	312	67	8	CID000004605
Drug	S 2-127	REN ACE	8.53e-06	2	67	2	CID000068371
Drug	endralazine	AFMID REN	8.53e-06	2	67	2	CID000047607
Drug	Sr 43845	REN ACE	8.53e-06	2	67	2	CID000163918
Drug	Spirapril HCl	REN ACE	8.53e-06	2	67	2	CID000071192
Drug	SCH 42495	REN ECE1 ACE	8.66e-06	14	67	3	CID000131965
Drug	ADP beta S	PLCXD3 REN ACE ADCY6 HAND2	9.42e-06	96	67	5	CID005310996
Drug	Sch 34826	REN ECE1 ACE	1.33e-05	16	67	3	CID000122184
Drug	2-bromoethylamine	AOC3 REN ALK	1.93e-05	18	67	3	CID000007851
Drug	orphenadrine	SIAE SCN4A AOC3 EEF1A2	2.24e-05	56	67	4	CID000004601
Drug	Cgp 38560a	REN ACE	2.55e-05	3	67	2	CID005487223
Drug	D03743	REN ACE	2.55e-05	3	67	2	CID000064922
Drug	Briserin	REN ACE	2.55e-05	3	67	2	CID000162769
Drug	AC1L1RNO	ECE1 ACE	2.55e-05	3	67	2	CID000034486
Drug	U-62066 [87151-85-7]; Up 200; 1uM; MCF7; HT_HG-U133A	PIK3CD MAN1C1 CTAGE1 CPEB3 ECE1 ALDH6A1	2.57e-05	198	67	6	4375_UP
Drug	candoxatrilat	REN ECE1 ACE	2.68e-05	20	67	3	CID000123697
Drug	NSC612475	REN ACE	5.10e-05	4	67	2	CID000003412
Drug	alpha-Lactorphin	REN ACE	5.10e-05	4	67	2	CID000128807
Drug	L-158,338	REN ACE	5.10e-05	4	67	2	CID003036053
Drug	Utibaprilo	REN ACE	5.10e-05	4	67	2	CID000060359
Drug	H 142	REN ACE	5.10e-05	4	67	2	CID000134897
Drug	AC1L9QEO	REN ACE	5.10e-05	4	67	2	CID000452589
Drug	BW-175	REN ACE	5.10e-05	4	67	2	CID000129247
Drug	Hoe 288	REN ACE	5.10e-05	4	67	2	CID000130318
Drug	NSC-701765	REN ACE	5.10e-05	4	67	2	CID000396210
Drug	AC1L1HJI	REN ACE	5.10e-05	4	67	2	CID000054684
Drug	BILA 2157 BS	REN ACE	5.10e-05	4	67	2	CID000157824
Drug	UK 79300	REN ECE1 ACE	5.35e-05	25	67	3	CID000122116
Drug	sodium bicarbonate	AOC3 REN ADCY6 SLC4A2	6.75e-05	74	67	4	CID000010340
Drug	Spiraprilate	REN ACE	8.48e-05	5	67	2	CID000134290
Drug	BMS-189921	REN ACE	8.48e-05	5	67	2	CID000172318
Drug	BW A575C	REN ACE	8.48e-05	5	67	2	CID000128240
Drug	EXP132	REN ACE	8.48e-05	5	67	2	CID000132313
Drug	T-1095A	REN ACE	8.48e-05	5	67	2	CID006918439
Drug	Nsc82118	AOC3 CFB	8.48e-05	5	67	2	CID000164749
Drug	AC1L1SQ2	REN ACE	8.48e-05	5	67	2	CID000060183
Drug	CGS 22989	REN ACE	8.48e-05	5	67	2	CID000130198
Drug	Enalkiren	REN ACE	8.48e-05	5	67	2	CID000060594
Drug	CGP 48369	REN ACE	8.48e-05	5	67	2	CID000192267
Drug	tebuconazole	BEST1 REN ACE	9.34e-05	30	67	3	CID000086102
Drug	NaBr	AFMID SIAE ABCA4	9.34e-05	30	67	3	CID000253881
Drug	calmidazolium chloride	SLC6A6 REN ACE ADCY6 SLC4A2	1.09e-04	160	67	5	CID000002531
Drug	coelenteramide	AFMID REN ACE	1.14e-04	32	67	3	CID005326781
Drug	dichlorprop	AFMID CHKB ACE	1.25e-04	33	67	3	CID000008427
Drug	ecadotril	REN ECE1 ACE	1.25e-04	33	67	3	CID000060561
Drug	B 4146	REN ACE	1.27e-04	6	67	2	CID000128385
Drug	E 4177	REN ACE	1.27e-04	6	67	2	CID000131857
Drug	Du 1777	REN ACE	1.27e-04	6	67	2	CID003081108
Drug	beta-Lactorphin	REN ACE	1.27e-04	6	67	2	CID000128808
Drug	EXP3312	REN ACE	1.27e-04	6	67	2	CID000196704
Drug	AC1Q5KBJ	REN ACE	1.27e-04	6	67	2	CID000064925
Drug	ethylglyoxal	AOC3 CFB	1.27e-04	6	67	2	CID000145744
Drug	Zankiren [INN]	REN ACE	1.27e-04	6	67	2	CID003036088
Drug	Acrip	REN ACE	1.27e-04	6	67	2	CID000163664
Drug	Ch 66	REN ACE	1.27e-04	6	67	2	CID000132260
Drug	salicylaldehyde	ABCA12 TNIP1 HAND2	1.49e-04	35	67	3	CID000006998
Drug	chlorthalidone	REN ACE ADCY6	1.62e-04	36	67	3	CID000002732
Drug	nalidixic acid	AFMID TNIP1 PLCXD3 REN CHKB ECE1	1.65e-04	277	67	6	CID000004421
Drug	bisoprolol	BEST1 REN ACE	1.76e-04	37	67	3	CID000002405
Drug	tasosartan	REN ACE	1.77e-04	7	67	2	CID000060919
Drug	Es 8891	REN ACE	1.77e-04	7	67	2	CID000195623
Drug	AC1L3Y6U	AOC3 CFB	1.77e-04	7	67	2	CID000097282
Drug	histargin	REN ACE	1.77e-04	7	67	2	CID000146414
Drug	octahydroindole-2-carboxylic acid	REN ACE	1.77e-04	7	67	2	CID003274680
Drug	Ym 21095	REN ACE	1.77e-04	7	67	2	CID000128978
Drug	Pentoprilum	REN ACE	1.77e-04	7	67	2	CID000054938
Drug	CGS 35601	ECE1 ACE	1.77e-04	7	67	2	ctd:C511403
Drug	Cp 71362	REN ACE	1.77e-04	7	67	2	CID000194951
Drug	zabicipril	REN ACE	1.77e-04	7	67	2	CID000071262
Drug	angiotensin	AFMID PLCXD3 REN ECE1 ACE ADCY6	1.81e-04	282	67	6	CID003083715
Drug	isethionate	REN CHKB SLC4A2	1.91e-04	38	67	3	CID000007866
Drug	chloride	AFMID SLC6A6 PTPRG SCN4A AOC3 REN CHKB ACE SLC4A3 ADCY6 SLC4A2	1.92e-04	1029	67	11	CID000000312
Drug	gluconate	GAK PIK3CD CHKB MOAP1 ADCY6 SLC4A2	1.99e-04	287	67	6	CID000000604
Drug	valinomycin	REN CHKB SLC4A2	2.06e-04	39	67	3	CID000005649
Drug	X x 5	REN ACE	2.36e-04	8	67	2	CID000448281
Drug	AC1L9NSO	AFMID EEF1A2	2.36e-04	8	67	2	CID000449971
Drug	cadralazine	REN ACE	2.36e-04	8	67	2	CID000002515
Drug	prizidilol	AFMID REN	2.36e-04	8	67	2	CID000071951
Drug	MK-996	REN ACE	2.36e-04	8	67	2	CID000133031
Drug	AC1NQY7T	REN ACE	2.36e-04	8	67	2	CID000064923
Drug	Abbott-81988	REN ACE	2.36e-04	8	67	2	CID000132387
Drug	mixanpril	REN ACE	2.36e-04	8	67	2	CID005492682
Drug	EXP3880	REN ACE	2.36e-04	8	67	2	CID000132149
Drug	CGS 25462	REN ACE	2.36e-04	8	67	2	CID000132812
Drug	Methiothepin maleate [19728-88-2]; Up 200; 8.4uM; MCF7; HT_HG-U133A	SLC6A6 MAN1C1 AOC3 ALK HERC5	2.38e-04	189	67	5	5413_UP
Drug	NaCl	AFMID SLC6A6 PIK3CD REN CHKB ACE ADCY6 SLC4A2	2.44e-04	564	67	8	CID000005234
Drug	Fusidic Acid-d6	TNIP1 CRB1 EEF1A2	2.58e-04	42	67	3	CID000003443
Drug	Hydrochlorothiazide	HLA-E REN ACE	2.58e-04	42	67	3	ctd:D006852
Drug	Hypertensin II	AFMID PIK3CD SCN4A REN ACE ADCY6 CFB	2.64e-04	429	67	7	CID000025476
Drug	Primaquine diphosphate [63-45-6]; Down 200; 8.8uM; PC3; HT_HG-U133A	GPALPP1 ZNF254 POLR1B SLC4A3 ADCY6	2.68e-04	194	67	5	4263_DN
Drug	Oxethazaine [126-27-2]; Up 200; 8.6uM; PC3; HG-U133A	RSBN1 ASXL1 ALDH6A1 PRRC2A MOAP1	2.75e-04	195	67	5	1903_UP
Drug	PD123177	SIAE REN ACE	2.76e-04	43	67	3	CID000114899
Drug	haloperidol; Up 200; 10uM; HL60; HT_HG-U133A	ABCA12 EXPH5 ZNF254 ABTB2 VPS13B	2.88e-04	197	67	5	6203_UP
Drug	0225151-0000 [351320-15-5]; Up 200; 10uM; MCF7; HT_HG-U133A	PIK3CD MAN1C1 NTRK3 AOC3 ALK	2.95e-04	198	67	5	6384_UP
Drug	Agent QL	AFMID CHKB ACE	2.96e-04	44	67	3	CID000170325
Drug	Foliosidine [2520-38-9]; Up 200; 13uM; PC3; HT_HG-U133A	PIK3CD MAN1C1 NTRK3 TBX21 CPEB3	3.02e-04	199	67	5	4295_UP
Drug	rapamycin, Streptomyces hygroscepicus; Down 200; 0.1uM; MCF7; HT_HG-U133A	PIK3CD MAN1C1 ZNF254 ALK HERC5	3.02e-04	199	67	5	5975_DN
Disease	Age-related macular degeneration	ABCA4 HMCN1 CFB	8.13e-06	18	65	3	cv:C0242383
Disease	Allanson Pantzar McLeod syndrome	REN ACE	2.86e-05	4	65	2	C0266313
Disease	Renal tubular dysgenesis	REN ACE	2.86e-05	4	65	2	cv:C0266313
Disease	Renal Tubular Dysgenesis With Choanal Atresia And Athelia	REN ACE	2.86e-05	4	65	2	C2678367
Disease	Renal tubular dysgenesis of genetic origin	REN ACE	2.86e-05	4	65	2	cv:C5681536
Disease	RENAL TUBULAR DYSGENESIS	REN ACE	2.86e-05	4	65	2	267430
Disease	macular degeneration (is_implicated_in)	BEST1 ABCA4 CFB	2.87e-05	27	65	3	DOID:4448 (is_implicated_in)
Disease	retinitis pigmentosa (implicated_via_orthology)	SLC6A6 RPGRIP1 CRB1	2.87e-05	27	65	3	DOID:10584 (implicated_via_orthology)
Disease	Age related macular degeneration	ABCA4 HMCN1 CFB	3.97e-05	30	65	3	C0242383
Disease	Retinitis Pigmentosa	RPGRIP1 BEST1 ABCA4 CRB1	8.36e-05	104	65	4	C0035334
Disease	pyelonephritis (is_marker_for)	ACE CFB	9.96e-05	7	65	2	DOID:11400 (is_marker_for)
Disease	retinitis pigmentosa (is_implicated_in)	RPGRIP1 ABCA4 CRB1	1.02e-04	41	65	3	DOID:10584 (is_implicated_in)
Disease	Congenital Amaurosis of Retinal Origin	RPGRIP1 CRB1	1.33e-04	8	65	2	C3540662
Disease	Microphthalmos	BEST1 CRB1	2.59e-04	11	65	2	C0026010
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	ACE SLC4A2	2.59e-04	11	65	2	DOID:0110861 (biomarker_via_orthology)
Disease	anemia (implicated_via_orthology)	SLC4A3 SLC4A2	4.93e-04	15	65	2	DOID:2355 (implicated_via_orthology)
Disease	type 1 diabetes mellitus (is_marker_for)	AOC3 ACE CFB	5.46e-04	72	65	3	DOID:9744 (is_marker_for)
Disease	Leber congenital amaurosis	RPGRIP1 CRB1	5.62e-04	16	65	2	cv:C0339527
Disease	Retinitis pigmentosa	BEST1 ABCA4 CRB1	5.91e-04	74	65	3	cv:C0035334
Disease	essential hypertension (is_implicated_in)	REN ECE1	7.15e-04	18	65	2	DOID:10825 (is_implicated_in)
Disease	congestive heart failure (is_marker_for)	AOC3 REN ECE1	7.98e-04	82	65	3	DOID:6000 (is_marker_for)
Disease	Hypertensive disease	AOC3 REN ECE1 ACE	8.30e-04	190	65	4	C0020538
Disease	type 1 diabetes mellitus (is_implicated_in)	ACE PRRC2A CFB	8.86e-04	85	65	3	DOID:9744 (is_implicated_in)
Disease	Leber Congenital Amaurosis	RPGRIP1 CRB1	1.07e-03	22	65	2	C0339527
Disease	Disorder of eye	RPGRIP1 BEST1 ABCA4 CRB1	1.24e-03	212	65	4	C0015397
Disease	Albuminuria	REN ACE	1.28e-03	24	65	2	C0001925
Disease	Left Ventricular Hypertrophy	REN ACE	1.39e-03	25	65	2	C0149721
Disease	acute kidney failure (implicated_via_orthology)	ECE1 ACE	1.62e-03	27	65	2	DOID:3021 (implicated_via_orthology)
Disease	primary biliary cholangitis (biomarker_via_orthology)	REN ACE	1.74e-03	28	65	2	DOID:12236 (biomarker_via_orthology)
Disease	Streptozotocin Diabetes	AOC3 REN ACE	1.77e-03	108	65	3	C0038433
Disease	Diabetes Mellitus, Experimental	AOC3 REN ACE	1.77e-03	108	65	3	C0011853
Disease	Alloxan Diabetes	AOC3 REN ACE	1.77e-03	108	65	3	C0002152
Disease	lower face morphology measurement	SFRP2 VPS13B CRB1	1.81e-03	109	65	3	EFO_0010948
Disease	Myocardial Failure	REN ACE HAND2	1.86e-03	110	65	3	C1959583
Disease	Congestive heart failure	REN ACE HAND2	1.86e-03	110	65	3	C0018802
Disease	Heart failure	REN ACE HAND2	1.86e-03	110	65	3	C0018801
Disease	Left-Sided Heart Failure	REN ACE HAND2	1.86e-03	110	65	3	C0023212
Disease	Heart Failure, Right-Sided	REN ACE HAND2	1.86e-03	110	65	3	C0235527
Disease	Heart Decompensation	REN ACE HAND2	1.86e-03	110	65	3	C1961112
Disease	Cone-Rod Dystrophy 2	RPGRIP1 ABCA4	1.87e-03	29	65	2	C3489532
Disease	myelodysplastic syndrome (is_implicated_in)	ASXL1 ARPC1B	2.00e-03	30	65	2	DOID:0050908 (is_implicated_in)
Disease	IgA glomerulonephritis (is_implicated_in)	ACE CFB	2.00e-03	30	65	2	DOID:2986 (is_implicated_in)
Disease	pneumonia, COVID-19	NTRK3 VPS13B UNC80	2.01e-03	113	65	3	EFO_0003106, MONDO_0100096
Disease	Hirschsprung Disease	NTRK3 ECE1	2.13e-03	31	65	2	C0019569

Protein segments in the cluster

Peptide	Gene	Start	Entry
MISRPAPGRMEWIIP	PTPRG	726	P23470
NPLGEKSPFPVWMMV	SLC4A2	981	P04920
KSPFPVWMMVASLLP	SLC4A2	986	P04920
GSARPFPPWMMVAAA	SLC4A3	976	P48751
FPPWMMVAAAVPALL	SLC4A3	981	P48751
AGPLAPPWEQDYRMM	CTAGE1	561	Q96RT6
FPNKAMPSAGMLPWL	ABCA4	56	P78363
SPMPPEFWEGSMLEK	ACE	336	P12821
SMEGLMPRWVPDRAF	ADCY6	576	O43306
MPAGPVIWAFLKPML	ABCA12	791	Q86UK0
APTPWGSKMPFGELM	ARPC1B	181	O15143
KMSPWDMEPIPEGTA	BRWD3	1096	Q6RI45
RMEPDMYWNKPEPQP	BEST1	331	O76090
GMEMPFTKEPHWLFG	CHKB	176	Q9Y259
AMAPPMKDLPRWLEE	CHD7	2661	Q9P2D1
GMPFVMDLPFWKLPR	ASXL1	1401	Q8IXJ9
RPMASGYGRMWEDPM	AKAP8L	191	Q9ULX6
AEDMVFVPMAVPWSP	AOC3	541	Q16853
MMDVSGVGFPSKVPW	AFMID	1	Q63HM1
AVYSMMSWPDDVPPE	CFB	361	P00751
GIAPFNFPAMIPLWM	ALDH6A1	181	Q02252
AASPRMVPRAPWMEQ	HLA-E	61	P13747
VGGHTMLPIRWMPPE	NTRK3	726	Q16288
LDPEQGMIPEMWAPM	MOAP1	131	Q96BY2
PAVMREESGMPPPWD	EXPH5	186	Q8NEV8
FNPVGKIWTVMPPMS	KLHL4	496	Q9C0H6
PAPKMTWMKDGRPLP	HMCN1	3556	Q96RW7
WLIGHPEMSPPDYSM	HAND2	46	P61296
MYPEGASCMWFPVKP	HERC5	746	Q9UII4
VYMFSMKRCPPGIWP	GAK	536	O14976
GDIMKMWGRVPFSPG	GIGYF2	581	Q6Y7W6
IWMEMAPSKPEPQGK	LINC01599	21	Q8WXQ3
PSGPPMSFADIMWRN	CPEB3	371	Q8NE35
MLEPSPNMPWFKGWK	EEF1A2	201	Q05639
WMTELPPEMKDFGLG	GPALPP1	191	Q8IXQ4
MLMRKVPGFVPASPW	MAN1C1	1	Q9NR34
KAPNRDQWSMTPPMV	ECE1	551	P42892
WLVPLMIGAPDMAFP	MT-CO1	81	P00395
KEGSRVEMWNLMPPP	CRB1	1386	P82279
RWMPLPEMEYNGNPE	SDK2	1116	Q58EX2
LWVDMFPMDMPAPGT	OTOF	1706	Q9HC10
WVRPGEQMIPTADMP	RSBN1	531	Q5VWQ0
LPMWMPDFFKGIRRP	KATNAL1	226	Q9BW62
APVMSAFGFPWPDML	SFRP2	126	Q96HF1
TMQVEEPPKSPEKMW	RPGRIP1	231	Q96KN7
GIEDMIGYRPGPWMK	SLC6A6	491	P31641
VFMTMSDPPPWSKNV	SCN4A	146	P35499
PIGMRMSPPAWVELK	PIWIL2	631	Q8TC59
WGEMPPLQPKHMREA	TAF11	176	Q15544
VDMARLGPEWSQPMK	REN	51	P00797
MMAAVPPGLEPWNRV	NEPRO	1	Q6NW34
PMNFDPRWMMIPPYV	PRRC2A	716	P48634
TWMVVLDPMKPGGPF	SIAE	81	Q9HAT2
PFMLLPPLMEWMRVA	ABTB2	416	Q8N961
GGCAMLPVKWMPPEA	ALK	1286	Q9UM73
LPVKWMPPEAFMEGI	ALK	1291	Q9UM73
DWSQIRYPPPPMAME	TNIP1	566	Q15025
MMPAPWANTTDPEKL	PLCXD3	211	Q63HM9
AQWAKLPVTPMPREM	WDR90	191	Q96KV7
MPREMAFPVPKGESW	WDR90	201	Q96KV7
MPSEFPWGDEIMLFL	UNC80	2176	Q8N2C7
MAWDETQPPKMKEIP	STPG3	51	Q8N7X2
MPPGVDCPMEFWTKE	PIK3CD	1	O00329
EPWNMKRHEMAAKPP	ZNF708	61	P17019
LSPAPMDWDMLMEPP	VWA5B2	801	Q8N398
EDCPGMMLWRYPEPR	VPS13B	2331	Q7Z7G8
MGTFPELMPPTLKWQ	SPTY2D1OS	16	A0A0U1RRN3
QGMDMASLPPRKRPW	WDR33	1221	Q9C0J8
PWMEVVLIPMTGKPS	POLR1B	591	Q9H9Y6
PDKHWIMRYTGPMKP	SULF2	256	Q8IWU5
PKMNPVVEPLSWMLG	THAP4	416	Q8WY91
KMGPASWFRPMRTLP	TBX21	441	Q9UL17
PWNMKRHEMVDEPPG	ZNF254	71	O75437