Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	beta-catenin binding	CDH23 PTPRK CDH1 CDH3 CDH11 CDH13 CDH15	3.02e-05	120	147	7	GO:0008013
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	SDK2 DSCAM PCDHA13 CDH23 PCDHA6 HMCN2 MYPN CDH1 CDH3 PCDH9 CDH11 CDH13 CDH15	8.16e-10	187	146	13	GO:0007156
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	SDK2 DSCAM PCDHA13 CDH23 PCDHA6 HMCN2 MYPN CDH1 CDH3 PCDH9 CDH11 CDH13 CDH15	3.68e-07	313	146	13	GO:0098742
GeneOntologyBiologicalProcess	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	CDH23 CDH1 CDH3 CDH11 CDH13 CDH15	1.98e-06	53	146	6	GO:0016339
GeneOntologyBiologicalProcess	cell-cell adhesion mediated by cadherin	CDH1 CDH3 CDH11 CDH13 CDH15	2.72e-05	50	146	5	GO:0044331
GeneOntologyBiologicalProcess	multicellular organismal reproductive process	ABAT TUT4 SPATA31A3 SPATA31A7 KIAA0319L SPATA31C2 SPATA31A6 CIT SPATA31A5 RLN1 RLN2 SPATA31A1 CHD5 MARF1 MASTL NCOA1 ROS1 GNAS CDH1 SPEM1 HTT PAQR7	3.49e-05	1194	146	22	GO:0048609
GeneOntologyBiologicalProcess	developmental process involved in reproduction	TUT4 SPATA31A3 SPATA31A7 KIAA0319L SPATA31C2 E2F7 SPATA31A6 CIT SPATA31A5 RLN1 RLN2 SPATA31A1 CHD5 MARF1 NCOA1 ROS1 GNAS PSAPL1 CDH1 SPEM1 HTT PAQR7	5.77e-05	1235	146	22	GO:0003006
GeneOntologyBiologicalProcess	gamete generation	TUT4 SPATA31A3 SPATA31A7 KIAA0319L SPATA31C2 SPATA31A6 CIT SPATA31A5 RLN1 RLN2 SPATA31A1 CHD5 MARF1 MASTL ROS1 GNAS SPEM1 HTT PAQR7	6.61e-05	982	146	19	GO:0007276
GeneOntologyBiologicalProcess	adherens junction organization	CDH1 CDH3 CDH11 CDH13 CDH15	7.17e-05	61	146	5	GO:0034332
GeneOntologyCellularComponent	catenin complex	CDH23 CDH1 CDH3 CDH11 CDH13 CDH15	8.86e-08	32	148	6	GO:0016342
GeneOntologyCellularComponent	extrinsic component of plasma membrane	CDH23 GNAS CDH1 CDH3 CDH11 CDH13 CDH15	5.52e-05	137	148	7	GO:0019897
Domain	CA	PCDHA13 CDH23 PCDHA6 FREM2 CDH1 CDH3 PCDH9 CDH11 CDH13 CDH15	1.55e-08	115	140	10	SM00112
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31C2 SPATA31A6 SPATA31A5	1.67e-08	12	140	5	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31C2 SPATA31A6 SPATA31A5	1.67e-08	12	140	5	IPR027970
Domain	Cadherin	PCDHA13 CDH23 PCDHA6 FREM2 CDH1 CDH3 PCDH9 CDH11 CDH13 CDH15	1.98e-08	118	140	10	IPR002126
Domain	Cadherin_CS	PCDHA13 CDH23 PCDHA6 CDH1 CDH3 PCDH9 CDH11 CDH13 CDH15	1.30e-07	109	140	9	IPR020894
Domain	CADHERIN_1	PCDHA13 CDH23 PCDHA6 CDH1 CDH3 PCDH9 CDH11 CDH13 CDH15	1.78e-07	113	140	9	PS00232
Domain	Cadherin	PCDHA13 CDH23 PCDHA6 CDH1 CDH3 PCDH9 CDH11 CDH13 CDH15	1.78e-07	113	140	9	PF00028
Domain	CADHERIN_2	PCDHA13 CDH23 PCDHA6 CDH1 CDH3 PCDH9 CDH11 CDH13 CDH15	1.92e-07	114	140	9	PS50268
Domain	-	PCDHA13 CDH23 PCDHA6 CDH1 CDH3 PCDH9 CDH11 CDH13 CDH15	1.92e-07	114	140	9	2.60.40.60
Domain	Cadherin-like	PCDHA13 CDH23 PCDHA6 CDH1 CDH3 PCDH9 CDH11 CDH13 CDH15	2.23e-07	116	140	9	IPR015919
Domain	Ig_I-set	ADAMTSL1 SDK2 DSCAM SPEG IGSF10 HMCN2 PTPRK MYPN ALPK2 MYBPC2	1.71e-06	190	140	10	IPR013098
Domain	I-set	ADAMTSL1 SDK2 DSCAM SPEG IGSF10 HMCN2 PTPRK MYPN ALPK2 MYBPC2	1.71e-06	190	140	10	PF07679
Domain	FN3_dom	SDK2 DSCAM SPEG KIAA0319L IFNLR1 LRRN4CL PTPRK ROS1 IL2RB MYBPC2	4.02e-06	209	140	10	IPR003961
Domain	Ig-like_fold	ADAMTSL1 SDK2 DSCAM TAPBPL SPEG CAMTA2 IFNLR1 IGSF10 HMCN2 LRRN4CL PTPRK MYPN ROS1 SEMA4A IL2RB ALPK2 TREML2 MYBPC2	5.70e-06	706	140	18	IPR013783
Domain	FN3	SDK2 DSCAM SPEG KIAA0319L LRRN4CL PTPRK ROS1 IL2RB MYBPC2	1.09e-05	185	140	9	SM00060
Domain	FN3	SDK2 DSCAM SPEG IFNLR1 LRRN4CL PTPRK ROS1 IL2RB MYBPC2	1.94e-05	199	140	9	PS50853
Domain	Cadherin_pro	CDH1 CDH3 CDH13	2.25e-05	8	140	3	SM01055
Domain	Cadherin_pro_dom	CDH1 CDH3 CDH13	2.25e-05	8	140	3	IPR014868
Domain	Cadherin_C	CDH1 CDH3 CDH11 CDH15	3.38e-05	25	140	4	PF01049
Domain	Cadherin_cytoplasmic-dom	CDH1 CDH3 CDH11 CDH15	3.38e-05	25	140	4	IPR000233
Domain	DUF3827	KIAA1549 KIAA1549L	5.58e-05	2	140	2	PF12877
Domain	DUF3827	KIAA1549 KIAA1549L	5.58e-05	2	140	2	IPR024606
Domain	Catenin_binding_dom	CDH1 CDH3 CDH11 CDH15	6.21e-05	29	140	4	IPR027397
Domain	-	CDH1 CDH3 CDH11 CDH15	6.21e-05	29	140	4	4.10.900.10
Domain	IGc2	ADAMTSL1 SDK2 DSCAM SPEG IGSF10 HMCN2 MYPN ALPK2 MYBPC2	7.12e-05	235	140	9	SM00408
Domain	Ig_sub2	ADAMTSL1 SDK2 DSCAM SPEG IGSF10 HMCN2 MYPN ALPK2 MYBPC2	7.12e-05	235	140	9	IPR003598
Domain	IG	ADAMTSL1 SDK2 DSCAM TAPBPL SPEG IGSF10 HMCN2 PTPRK MYPN ALPK2 TREML2 MYBPC2	7.97e-05	421	140	12	SM00409
Domain	Ig_sub	ADAMTSL1 SDK2 DSCAM TAPBPL SPEG IGSF10 HMCN2 PTPRK MYPN ALPK2 TREML2 MYBPC2	7.97e-05	421	140	12	IPR003599
Domain	-	ADAMTSL1 SDK2 DSCAM TAPBPL SPEG IFNLR1 IGSF10 LRRN4CL PTPRK MYPN ROS1 IL2RB ALPK2 TREML2 MYBPC2	1.38e-04	663	140	15	2.60.40.10
Domain	Relaxin	RLN1 RLN2	1.67e-04	3	140	2	IPR022421
Domain	fn3	SDK2 DSCAM SPEG LRRN4CL PTPRK ROS1 MYBPC2	2.22e-04	162	140	7	PF00041
Domain	IG_LIKE	ADAMTSL1 SDK2 DSCAM TAPBPL SPEG IGSF10 HMCN2 PTPRK MYPN ALPK2 TREML2 MYBPC2	3.31e-04	491	140	12	PS50835
Domain	Ig-like_dom	ADAMTSL1 SDK2 DSCAM TAPBPL SPEG IGSF10 HMCN2 PTPRK MYPN ALPK2 TREML2 MYBPC2	4.11e-04	503	140	12	IPR007110
Domain	CUB	LRP12 DCBLD1 LRP3 PCOLCE	4.93e-04	49	140	4	PF00431
Domain	CUB	LRP12 DCBLD1 LRP3 PCOLCE	5.33e-04	50	140	4	SM00042
Domain	-	LRP12 DCBLD1 LRP3 PCOLCE	6.19e-04	52	140	4	2.60.120.290
Domain	CUB	LRP12 DCBLD1 LRP3 PCOLCE	6.66e-04	53	140	4	PS01180
Domain	Insulin_family	RLN1 RLN2	8.20e-04	6	140	2	IPR022352
Domain	AGC-kinase_C	RPS6KA4 CIT MASTL PKN2	8.21e-04	56	140	4	IPR000961
Domain	AGC_KINASE_CTER	RPS6KA4 CIT MASTL PKN2	8.21e-04	56	140	4	PS51285
Domain	S_TK_X	RPS6KA4 CIT MASTL PKN2	8.21e-04	56	140	4	SM00133
Domain	CUB_dom	LRP12 DCBLD1 LRP3 PCOLCE	8.78e-04	57	140	4	IPR000859
Domain	Cadherin_pro	CDH1 CDH13	1.14e-03	7	140	2	PF08758
Domain	Calx_beta	FRAS1 FREM2	1.52e-03	8	140	2	SM00237
Domain	Calx_beta	FRAS1 FREM2	1.94e-03	9	140	2	IPR003644
Domain	Insulin_CS	RLN1 RLN2	1.94e-03	9	140	2	IPR022353
Domain	-	RLN1 RLN2	1.94e-03	9	140	2	1.10.100.10
Domain	Calx-beta	FRAS1 FREM2	1.94e-03	9	140	2	PF03160
Domain	INSULIN	RLN1 RLN2	2.41e-03	10	140	2	PS00262
Domain	Insulin	RLN1 RLN2	2.41e-03	10	140	2	PF00049
Domain	Pkinase_C	RPS6KA4 CIT PKN2	2.66e-03	37	140	3	IPR017892
Domain	Insulin	RLN1 RLN2	2.94e-03	11	140	2	IPR004825
Domain	Insulin-like	RLN1 RLN2	2.94e-03	11	140	2	IPR016179
Domain	IlGF	RLN1 RLN2	2.94e-03	11	140	2	SM00078
Pathway	REACTOME_CELL_JUNCTION_ORGANIZATION	SDK2 MEGF6 AMOT CDH3 CDH11 CDH13 CDH15	4.95e-07	73	93	7	MM15126
Pathway	REACTOME_CELL_CELL_JUNCTION_ORGANIZATION	SDK2 AMOT CDH3 CDH11 CDH13 CDH15	6.88e-07	48	93	6	MM15069
Pathway	REACTOME_CELL_CELL_JUNCTION_ORGANIZATION	SDK2 AMOT CDH1 CDH3 CDH11 CDH13 CDH15	2.07e-06	90	93	7	M820
Pathway	REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS	AMOT CDH1 CDH3 CDH11 CDH13 CDH15	2.15e-06	58	93	6	M11980
Pathway	REACTOME_CELL_CELL_COMMUNICATION	SDK2 MEGF6 AMOT CDH3 CDH11 CDH13 CDH15	3.20e-06	96	93	7	MM14592
Pathway	REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS	AMOT CDH3 CDH11 CDH13 CDH15	6.15e-06	40	93	5	MM15060
Pathway	REACTOME_CELL_JUNCTION_ORGANIZATION	SDK2 AMOT CDH1 CDH3 CDH11 CDH13 CDH15	1.19e-05	117	93	7	M19248
Pathway	WP_HIPPO_SIGNALING_REGULATION	GNAS CDH1 CDH3 CDH11 CDH13 CDH15	4.53e-05	98	93	6	M39830
Pathway	REACTOME_CELL_CELL_COMMUNICATION	SDK2 AMOT CDH1 CDH3 CDH11 CDH13 CDH15	7.28e-05	155	93	7	M522
Pathway	WP_HIPPOMERLIN_SIGNALING_DYSREGULATION	AMOT CDH1 CDH3 CDH11 CDH13 CDH15	1.46e-04	121	93	6	M39823
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	8.34e-12	6	150	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	8.34e-12	6	150	5	25930072
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NR2F6 FRAS1 SZT2 ESYT1 SPEG KIAA0319L HECTD4 LAMB2 EDC4 CIT IFNLR1 KIAA2013 C2CD2L RPAP1 MEGF6 CHD5 CSPG4 HELZ2 LRP3 RIPOR1 ARRDC2 ZNF839 ALKBH6 GGA1 HTT	1.21e-11	1105	150	25	35748872
Pubmed	Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.	CDH1 CDH3 CDH11 CDH13 CDH15	1.75e-09	13	150	5	9615235
Pubmed	Cadherin expression in the developing mouse olfactory system.	CDH1 CDH3 CDH11 CDH13 CDH15	5.87e-09	16	150	5	17278136
Pubmed	E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.	CDH1 CDH3 CDH11 CDH13 CDH15	2.05e-08	20	150	5	7806582
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	5.55e-08	24	150	5	32212159
Pubmed	Expression of T-cadherin in Basal keratinocytes of skin.	CDH1 CDH3 CDH13	7.86e-08	3	150	3	12060406
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FKBP15 FRAS1 SPEG CAMTA2 RUSC2 C2CD2L RPAP1 SLIT1 GIGYF2 RIPOR1 KIF17 TET3	2.27e-07	407	150	12	12693553
Pubmed	Segmental and restricted localization pattern of Fras1 in the developing meningeal basement membrane in mouse.	FRAS1 LAMB2 FREM2	3.14e-07	4	150	3	24101214
Pubmed	Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse.	CDH1 CDH3 CDH11 CDH13	4.37e-07	15	150	4	33833667
Pubmed	No evidence of involvement of E-cadherin in cell fate specification or the segregation of Epi and PrE in mouse blastocysts.	CDH1 CDH3 CDH11 CDH13	4.37e-07	15	150	4	30735538
Pubmed	Differential expression and function of cadherin-6 during renal epithelium development.	CDH1 CDH3 CDH11	7.81e-07	5	150	3	9449663
Pubmed	Beyond E-cadherin: roles of other cadherin superfamily members in cancer.	CDH1 CDH3 CDH13	7.81e-07	5	150	3	24442140
Pubmed	Angiomotin is a novel component of cadherin-11/β-catenin/p120 complex and is critical for cadherin-11-mediated cell migration.	AMOT CDH1 CDH11	7.81e-07	5	150	3	25466890
Pubmed	Cloning and expression analysis of a novel mesodermally expressed cadherin.	CDH1 CDH3 CDH11	7.81e-07	5	150	3	7750649
Pubmed	The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species.	CDH1 CDH3 CDH15	1.56e-06	6	150	3	1427864
Pubmed	Characterization of cadherins expressed by murine thymocytes.	CDH1 CDH11 CDH13	2.72e-06	7	150	3	8620560
Pubmed	A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction.	CDH1 CDH3 CDH11	2.72e-06	7	150	3	8879495
Pubmed	Pitx3 directly regulates Foxe3 during early lens development.	E4F1 CDH1 PROX1	6.48e-06	9	150	3	24307298
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SCO2 OGT SZT2 ZNF629 E2F7 PCDHA13 EDC4 C2orf72 MGAT2 SBNO1 ELMO2 NCOA1 ANKRD17 GIGYF2 FBXO21 ENO3 HTT HDLBP	1.79e-05	1327	150	18	32694731
Pubmed	OGT Controls the Expression and the Glycosylation of E-cadherin, and Affects Glycosphingolipid Structures in Human Colon Cell Lines.	OGT CDH1	1.85e-05	2	150	2	31373757
Pubmed	Structural and energetic determinants of adhesive binding specificity in type I cadherins.	CDH1 CDH3	1.85e-05	2	150	2	25253890
Pubmed	Identification of two novel CAKUT-causing genes by massively parallel exon resequencing of candidate genes in patients with unilateral renal agenesis.	FRAS1 FREM2	1.85e-05	2	150	2	21900877
Pubmed	Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination.	RLN1 RLN2	1.85e-05	2	150	2	2040595
Pubmed	Expression of E- and P-cadherin during tooth morphogenesis and cytodifferentiation of ameloblasts.	CDH1 CDH3	1.85e-05	2	150	2	9682977
Pubmed	Structural characterization by mass spectrometry of native and recombinant human relaxin.	RLN1 RLN2	1.85e-05	2	150	2	2076464
Pubmed	[Cadherins E and P expression in the molecular types of breast cancer].	CDH1 CDH3	1.85e-05	2	150	2	26299056
Pubmed	Expression and functional role of E- and P-cadherins in mouse mammary ductal morphogenesis and growth.	CDH1 CDH3	1.85e-05	2	150	2	7781895
Pubmed	TET3-OGT interaction increases the stability and the presence of OGT in chromatin.	OGT TET3	1.85e-05	2	150	2	24304661
Pubmed	SNP rs9387478 at ROS1-DCBLD1 Locus is Significantly Associated with Lung Cancer Risk and Poor Survival in Indian Population.	DCBLD1 ROS1	1.85e-05	2	150	2	36308382
Pubmed	Relaxin, insulin and diabetes: an intriguing connection.	RLN1 RLN2	1.85e-05	2	150	2	22698078
Pubmed	Aberrant methylation of E-cadherin and H-cadherin genes in nonsmall cell lung cancer and its relation to clinicopathologic features.	CDH1 CDH13	1.85e-05	2	150	2	17960794
Pubmed	Mucoepidermoid carcinoma of the thyroid: a tumour histotype characterised by P-cadherin neoexpression and marked abnormalities of E-cadherin/catenins complex.	CDH1 CDH3	1.85e-05	2	150	2	12021924
Pubmed	Isolation and analysis of the 3'-untranslated regions of the human relaxin H1 and H2 genes.	RLN1 RLN2	1.85e-05	2	150	2	10750025
Pubmed	Molecular study of 33 families with Fraser syndrome new data and mutation review.	FRAS1 FREM2	1.85e-05	2	150	2	18671281
Pubmed	E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements.	CDH1 CDH3	1.85e-05	2	150	2	32572153
Pubmed	Differential expression of E-cadherin and P-cadherin in pT3 prostate cancer: correlation with clinical and pathological features.	CDH1 CDH3	1.85e-05	2	150	2	30006753
Pubmed	Novel loss of function variants in FRAS1 AND FREM2 underlie renal agenesis in consanguineous families.	FRAS1 FREM2	1.85e-05	2	150	2	32643034
Pubmed	Regulation of E- and P-cadherin expression correlated with melanocyte migration and diversification.	CDH1 CDH3	1.85e-05	2	150	2	10545227
Pubmed	Differential spatiotemporal expression of E- and P-cadherin during mouse tooth development.	CDH1 CDH3	1.85e-05	2	150	2	8619966
Pubmed	CDH1 and CDH13 methylation in serum is an independent prognostic marker in cervical cancer patients.	CDH1 CDH13	1.85e-05	2	150	2	14750164
Pubmed	A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay.	EDC4 MARF1	1.85e-05	2	150	2	32510323
Pubmed	Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces.	CDH1 CDH3	1.85e-05	2	150	2	23277553
Pubmed	Reciprocal altered expression of E-cadherin and P-cadherin in mucous membrane pemphigoid.	CDH1 CDH3	1.85e-05	2	150	2	21781454
Pubmed	Expression and role of E- and P-cadherin adhesion molecules in embryonic histogenesis. II. Skin morphogenesis.	CDH1 CDH3	1.85e-05	2	150	2	2806126
Pubmed	Expression and role of E- and P-cadherin adhesion molecules in embryonic histogenesis. I. Lung epithelial morphogenesis.	CDH1 CDH3	1.85e-05	2	150	2	2806125
Pubmed	Two human relaxin genes are on chromosome 9.	RLN1 RLN2	1.85e-05	2	150	2	6548703
Pubmed	Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones.	RLN1 RLN2	1.85e-05	2	150	2	6548702
Pubmed	Tumor-specific downregulation and methylation of the CDH13 (H-cadherin) and CDH1 (E-cadherin) genes correlate with aggressiveness of human pituitary adenomas.	CDH1 CDH13	1.85e-05	2	150	2	17873891
Pubmed	Expression of human relaxin genes: characterization of a novel alternatively-spliced human relaxin mRNA species.	RLN1 RLN2	1.85e-05	2	150	2	8735594
Pubmed	Clinical relevance of CDH1 and CDH13 DNA-methylation in serum of cervical cancer patients.	CDH1 CDH13	1.85e-05	2	150	2	22942707
Pubmed	Identification of a novel fusion transcript between human relaxin-1 (RLN1) and human relaxin-2 (RLN2) in prostate cancer.	RLN1 RLN2	1.85e-05	2	150	2	26499396
Pubmed	TET3- and OGT-Dependent Expression of Genes Involved in Epithelial-Mesenchymal Transition in Endometrial Cancer.	OGT TET3	1.85e-05	2	150	2	34948036
Pubmed	A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos.	CDH1 CDH3	1.85e-05	2	150	2	3539943
Pubmed	Frequent aerogenous spread with decreased E-cadherin expression of ROS1-rearranged lung cancer predicts poor disease-free survival.	ROS1 CDH1	1.85e-05	2	150	2	26149475
Pubmed	RNAi-mediated knockdown of relaxin decreases in vitro proliferation and invasiveness of osteosarcoma MG-63 cells by inhibition of MMP-9.	RLN1 RLN2	1.85e-05	2	150	2	23661525
Pubmed	Isolation of placental cadherin cDNA: identification of a novel gene family of cell-cell adhesion molecules.	CDH1 CDH3	1.85e-05	2	150	2	3428270
Pubmed	Relaxin promotes prostate cancer progression.	RLN1 RLN2	1.85e-05	2	150	2	17363522
Pubmed	Similarities in structure and expression between mouse P-cadherin, chicken B-cadherin and frog XB/U-cadherin.	CDH1 CDH3	1.85e-05	2	150	2	7743137
Pubmed	Human seminal relaxin is a product of the same gene as human luteal relaxin.	RLN1 RLN2	1.85e-05	2	150	2	1572287
Pubmed	Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes and their chromosomal localization on chromosome 9p24.1 by radiation hybrid and breakpoint mapping.	RLN1 RLN2	1.85e-05	2	150	2	10601981
Pubmed	Serum relaxin levels in benign hypermobility syndrome.	RLN1 RLN2	1.85e-05	2	150	2	25322737
Pubmed	The relaxin peptide family--structure, function and clinical applications.	RLN1 RLN2	1.85e-05	2	150	2	20858209
Pubmed	A potential role for the CDH13/CDH15 gene in repeat revascularization after first percutaneous coronary intervention.	CDH13 CDH15	1.85e-05	2	150	2	31854260
Pubmed	Differential Expression of E-Cadherin and P-Cadherin in Breast Cancer Molecular Subtypes.	CDH1 CDH3	1.85e-05	2	150	2	32988879
Pubmed	Expression of the human relaxin H1 gene in the decidua, trophoblast, and prostate.	RLN1 RLN2	1.85e-05	2	150	2	2005217
Pubmed	Relaxin: structures, functions, promises, and nonevolution.	RLN1 RLN2	1.85e-05	2	150	2	7958621
Pubmed	Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues.	CDH1 CDH3	1.85e-05	2	150	2	2793940
Pubmed	X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants.	RLN1 RLN2	1.85e-05	2	150	2	1656049
Pubmed	Serum relaxin as a diagnostic and prognostic marker in patients with epithelial ovarian cancer.	RLN1 RLN2	1.85e-05	2	150	2	29060928
Pubmed	Relaxin gene expression in human reproductive tissues by in situ hybridization.	RLN1 RLN2	1.85e-05	2	150	2	7829601
Pubmed	Genomic organization and chromosomal mapping of the mouse P-cadherin gene.	CDH1 CDH3 CDH15	2.76e-05	14	150	3	1886768
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SCO2 TUT4 OGT MAZ ZNF629 KIAA1549 C2CD2L ZNF8 INTS14 HMCN2 CHD5 ANKRD17 XYLB KIF18B CDH15 PROX1	2.79e-05	1116	150	16	31753913
Pubmed	Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome.	FRAS1 FREM2 CDH1	3.44e-05	15	150	3	23064016
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	FRAS1 FREM2 CSPG4	4.23e-05	16	150	3	16880404
Pubmed	Relaxin treatment reduces angiotensin II-induced vasoconstriction in pregnancy and protects against endothelial dysfunction†.	RLN1 RLN2	5.53e-05	3	150	2	28379296
Pubmed	Relaxin regulates myofibroblast contractility and protects against lung fibrosis.	RLN1 RLN2	5.53e-05	3	150	2	21983071
Pubmed	Cadherins and tissue formation: integrating adhesion and signaling.	CDH1 CDH3	5.53e-05	3	150	2	10333730
Pubmed	Identification of imprinted loci by methylation-sensitive representational difference analysis: application to mouse distal chromosome 2.	GNAS CDH15	5.53e-05	3	150	2	10610704
Pubmed	Reversal by relaxin of altered ileal spontaneous contractions in dystrophic (mdx) mice through a nitric oxide-mediated mechanism.	RLN1 RLN2	5.53e-05	3	150	2	17522128
Pubmed	The INSL4 gene maps close to WI-5527 at 9p24.1-->p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome.	RLN1 RLN2	5.53e-05	3	150	2	9730618
Pubmed	The complex CBX7-PRMT1 has a critical role in regulating E-cadherin gene expression and cell migration.	CBX7 CDH1	5.53e-05	3	150	2	30826432
Pubmed	Site-related Effects of Relaxin in the Gastrointestinal Tract Through Nitric Oxide Signalling: An Updated Report.	RLN1 RLN2	5.53e-05	3	150	2	28606038
Pubmed	The significance of beta-catenin, E-cadherin, and P-cadherin expressions in neoplastic progression of colorectal mucosa: an immunohistochemical study.	CDH1 CDH3	5.53e-05	3	150	2	18330089
Pubmed	Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo.	RLN1 RLN2	5.53e-05	3	150	2	15155573
Pubmed	Mice without a functional relaxin gene are unable to deliver milk to their pups.	RLN1 RLN2	5.53e-05	3	150	2	9886856
Pubmed	Relaxin 2 is functional at the ocular surface and promotes corneal wound healing.	RLN1 RLN2	5.53e-05	3	150	2	23111608
Pubmed	Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis.	RLN1 RLN2	5.53e-05	3	150	2	12424226
Pubmed	The mouse relaxin gene: nucleotide sequence and expression.	RLN1 RLN2	5.53e-05	3	150	2	8452637
Pubmed	Polymorphisms in the promoter region of relaxin-2 and preterm birth: involvement of relaxin in the etiology of preterm birth.	RLN1 RLN2	5.53e-05	3	150	2	20023247
Pubmed	Skeletal myoblasts overexpressing relaxin improve differentiation and communication of primary murine cardiomyocyte cell cultures.	RLN1 RLN2	5.53e-05	3	150	2	19465027
Pubmed	Sex-dependent expression of placental (P)-cadherin during mouse gonadogenesis.	CDH1 CDH3	5.53e-05	3	150	2	8955792
Pubmed	Normal mammary gland growth and lactation capacity in pregnant relaxin-deficient mice.	RLN1 RLN2	5.53e-05	3	150	2	19383261
Pubmed	Anti-atherosclerotic effects of serelaxin in apolipoprotein E-deficient mice.	RLN1 RLN2	5.53e-05	3	150	2	27341752
Pubmed	Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis.	RLN1 RLN2	5.53e-05	3	150	2	17095590
Pubmed	A vasoactive role for endogenous relaxin in mesenteric arteries of male mice.	RLN1 RLN2	5.53e-05	3	150	2	25243460
Pubmed	The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of nonreproductive organs.	RLN1 RLN2	5.53e-05	3	150	2	16935837
Pubmed	Relaxin reverses airway remodeling and airway dysfunction in allergic airways disease.	RLN1 RLN2	5.53e-05	3	150	2	19213838
Pubmed	Relaxin is a key mediator of prostate growth and male reproductive tract development.	RLN1 RLN2	5.53e-05	3	150	2	12861045
Interaction	TOP3B interactions	SCO2 NR2F6 FRAS1 SZT2 ESYT1 SPEG KIAA0319L HECTD4 LAMB2 EDC4 CIT MCRIP2 IFNLR1 KIAA2013 C2CD2L RPAP1 MEGF6 FASTK CHD5 CSPG4 HELZ2 LRP3 ANKRD17 RIPOR1 GNAS ARRDC2 ZNF839 ALKBH6 GGA1 HTT HDLBP	3.88e-08	1470	144	31	int:TOP3B
Interaction	PCDHGB1 interactions	SDK2 ITFG1 C2CD2L FREM2 PTPRK CDH3 PCDH9	1.30e-06	77	144	7	int:PCDHGB1
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	2.93e-04	8	150	2	chr9q12
Cytoband	Ensembl 112 genes in cytogenetic band chr16q22	EDC4 PKD1L3 RIPOR1 CDH1 CDH3	3.53e-04	183	150	5	chr16q22
Cytoband	16q22.1	EDC4 RIPOR1 CDH1 CDH3	4.83e-04	110	150	4	16q22.1
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ADAMTSL1 SDK2 DSCAM SPEG IGSF10 HMCN2 MYPN ALPK2 MYBPC2	1.57e-07	161	94	9	593
GeneFamily	CD molecules\|Type I classical cadherins	CDH1 CDH3 CDH15	1.35e-06	5	94	3	1185
GeneFamily	Fibronectin type III domain containing	SDK2 DSCAM LRRN4CL PTPRK ROS1 MYBPC2	1.87e-04	160	94	6	555
GeneFamily	Low density lipoprotein receptors	LRP12 LRP3	2.01e-03	13	94	2	634
Coexpression	GSE2405_S_AUREUS_VS_A_PHAGOCYTOPHILUM_NEUTROPHIL_DN	SZT2 KIAA0319L E4F1 CIT C2CD2L RPAP1 PHACTR4 HELZ2 CBX7	1.82e-06	200	145	9	M6208
Coexpression	GSE42724_B1_BCELL_VS_PLASMABLAST_UP	MCRIP2 RLN1 LRRN4CL NACC2 MOCS3 HPS4 RIPOR1 XYLB	1.57e-05	199	145	8	M9787
Coexpression	GSE2405_HEAT_KILLED_LYSATE_VS_LIVE_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_24H_DN	HDAC11 E2F7 CIT RPAP1 PTPRK ZNF518B SEMA4A PCOLCE	1.63e-05	200	145	8	M6201
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FRAS1 LAMB2 KIAA1549L CSPG4 CPXM1 CDH11 CDH15 PCOLCE	3.86e-07	200	149	8	ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KIAA1549 FAM228A IGSF10 KIAA1549L CPXM1 SPINDOC PCOLCE	1.60e-06	168	149	7	d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FRAS1 ADAMTSL1 CIT FREM2 PTPRK ROS1 PCDH9	2.45e-06	179	149	7	815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCell	Basal\|World / shred by cell class for mouse tongue	FREM2 MEGF6 CSPG4 SLIT1 WNT10A CDH3 CDH13	2.83e-06	183	149	7	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTSL1 CIT FREM2 PTPRK ROS1 CDH1 PCDH9	3.15e-06	186	149	7	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SDK2 PLPP5 ZNF629 MEGF6 MOCS3 PCDH9	1.44e-05	156	149	6	7ece590fd8f29382e349dd0e5e016d2926aeb518
ToppCell	COVID-CD8-memory_CD4\|COVID / Condition, Cell_class and T cell subcluster	HDAC11 CDH23 RLN2 MOCS3 NCOA1 SPINDOC	1.78e-05	162	149	6	22b2a32217d357146c117e618813d451510a1801
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Lymphocytic-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHLD2 SPEG ZNF629 METTL4 SEMA4A TREML2	1.98e-05	165	149	6	475905d608fac628960188ae4a18010b8097417e
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TUT4 PLPP5 PTPRK MARF1 RIPOR1 PCDH9	1.98e-05	165	149	6	fead3f2032f8fa5f7f0159a4434989b3d65debbb
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FRAS1 ADAMTSL1 ARHGAP22 FREM2 LRRN4CL PCOLCE	2.12e-05	167	149	6	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FRAS1 ADAMTSL1 ARHGAP22 FREM2 LRRN4CL PCOLCE	2.12e-05	167	149	6	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIT SHANK3 MEGF6 CSPG4 PCDH9 CDH13	2.34e-05	170	149	6	50c6c571591aa4b218caefe5778c570c809f567e
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIT SHANK3 MEGF6 CSPG4 PCDH9 CDH13	2.34e-05	170	149	6	8fe32dcf924d5f6665f7febbc9647d96b1e96f06
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIT SHANK3 MEGF6 CSPG4 PCDH9 CDH13	2.34e-05	170	149	6	3232db50b1a40f861e981a1b9c9073b81af9f832
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SDK2 PLPP5 PTPRK WNT10A RIPOR1 MYBPC2	2.42e-05	171	149	6	c3e3ea09c73050372314a89b282e36ba5f339d73
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAZ HECTD4 ASTE1 KIAA1549L PCDH9 PAQR7	2.75e-05	175	149	6	1d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAZ HECTD4 ASTE1 KIAA1549L PCDH9 PAQR7	2.75e-05	175	149	6	427a7ee92fe16a90625946492062d37aa0f7235b
ToppCell	facs-Marrow-B-cells-18m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLPP5 CDH23 NACC2 WNT10A SPEM1 PROX1	2.84e-05	176	149	6	5f9ae5eb45603ed0422a3a993ecdbe2ce05d6e45
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SDK2 PLPP5 PTPRK MARF1 PCDH9 TREML2	2.84e-05	176	149	6	ad05dd934f4ac2e656b3455de091f4c8772de6c8
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DSCAM SHANK3 PRX HMCN2 MYPN CDH13	2.84e-05	176	149	6	64e426f5e84884ce2c29acf6f4b958962a63927f
ToppCell	facs-Marrow-B-cells-18m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLPP5 CDH23 NACC2 WNT10A SPEM1 PROX1	2.94e-05	177	149	6	35d42b07d9c31528bf59199e361bb8a3bfbe3b75
ToppCell	B_cells-Naive_B_cells_\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	ABAT HECTD4 PTPRK ARRDC2 PCDH9 MYBPC2	3.03e-05	178	149	6	71ac2eca5cf13a91f86b80690748b0788392dcfc
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	TAPBPL SPATA31A7 DCBLD1 E4F1 CAMTA2 HDLBP	3.22e-05	180	149	6	81d60f0fa9e3b5bfcec85139a0a49e9130145f0e
ToppCell	droplet-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 REXO5 SHANK3 LRRN4CL MEGF6 AMOT	3.76e-05	185	149	6	6a85399cfdb9b89683c874e7f046957f9a601dc2
ToppCell	droplet-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 REXO5 SHANK3 LRRN4CL MEGF6 AMOT	3.76e-05	185	149	6	64791056cdbb739136dbef08f4b16e2b5427faad
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM KIAA1549 ARHGAP22 CSPG4 CPXM1 CDH13	4.11e-05	188	149	6	7471c194276161422326647f09022e94f3d1640c
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ABAT ZNF629 RUSC2 ELMO2 CDH11 PROX1	4.11e-05	188	149	6	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM KIAA1549 ARHGAP22 CSPG4 CPXM1 CDH13	4.11e-05	188	149	6	053c251d3ddbeb866f34565aefca4535517b4387
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_mature\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CDH23 FAM228A CHD5 CPXM1 KIF17	4.26e-05	115	149	5	c3f6efb90d5ee01af831f65e240505faa6a71dc0
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FRAS1 ADAMTSL1 FREM2 PTPRK ROS1 CDH1	4.36e-05	190	149	6	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	HDAC11 EGLN2 PRX MOCS3 HPS4	4.44e-05	116	149	5	f32f7eddfe33adb3b5cf7c34667a481a305c5163
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAMTSL1 CIT FREM2 KIF18B CDH1 CDH3	4.49e-05	191	149	6	39220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL1 IGSF10 LRRN4CL CPXM1 CDH11 PCOLCE	4.49e-05	191	149	6	24dc77ee8de01b42559f92721655f4281b114e17
ToppCell	droplet-Kidney-nan-18m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 IGSF10 LRRN4CL CPXM1 PCDH9 CDH11	4.62e-05	192	149	6	38d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IGSF10 HMCN2 KIAA1549L CPXM1 CDH11 PCOLCE	4.62e-05	192	149	6	29bee88b45e23f16543ffc7cc361bc5da5d16a2b
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 IGSF10 LRRN4CL CPXM1 PCDH9 CDH11	4.62e-05	192	149	6	04d155897ed075c359933080e36a4ab2150b6e9f
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 IGSF10 LRRN4CL CPXM1 PCDH9 CDH11	4.62e-05	192	149	6	84149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IGSF10 HMCN2 KIAA1549L CPXM1 CDH11 PCOLCE	4.62e-05	192	149	6	cdc652dbfabe41b324fd85c1ed933d29fb73a49f
ToppCell	Fibroblasts-CD55+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ADAMTSL1 SPEG LRRN4CL CSPG4 MYPN CDH13	4.76e-05	193	149	6	8f4bf9a2fbedae35432dad96730b00c70185874c
ToppCell	COVID-19-lung-Proliferative_fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	REXO5 E2F7 CIT KIF18B CDH11 PCOLCE	5.18e-05	196	149	6	2ce8a787f2731faa913d20342d73041d59468f27
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LAMB2 IGSF10 FREM2 PCDH9 CDH15 PCOLCE	5.18e-05	196	149	6	b8b9801181d7604871b48aebacb295d0a57a5eaf
ToppCell	Bronchial_Brush-Epithelial-Basal_1\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	FRAS1 MEGF6 WNT10A SEMA4A CDH11 CDH13	5.33e-05	197	149	6	f5d87824c0020c95d89e069fd9f70b49e5d5fcea
ToppCell	mild-pDC\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RPS6KA4 CDH23 IGSF10 WNT10A CDH1 KIF17	5.33e-05	197	149	6	15230a54fa5903dd728de1a0ad633bd2d2c7a04d
ToppCell	LPS_only-Hematopoietic_Myeloid-Dendritic_cells-mDC\|LPS_only / Treatment groups by lineage, cell group, cell type	ABAT PKD1L3 ARHGAP22 IDO2 ENO3 ALPK2	5.48e-05	198	149	6	53c22e81e530d6fc272d4a45c8d1bf125feb254d
ToppCell	(5)_Fibroblast-G\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	FRAS1 IGSF10 SLIT1 CDH11 CDH13 PCOLCE	5.64e-05	199	149	6	b4a737575be9f8c65771832dd8cd25328d5dae0d
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	FRAS1 SDK2 IGSF10 CDH11 CDH13 PCOLCE	5.80e-05	200	149	6	aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FRAS1 SDK2 IGSF10 CDH11 CDH13 PCOLCE	5.80e-05	200	149	6	a510deaada669e690329183e18df02870bd204b3
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-Mesoderm\|6m / Sample Type, Dataset, Time_group, and Cell type.	MYPN CDH1 ENO3 ALPK2 CDH15 MYBPC2	5.80e-05	200	149	6	0f6851baf0cf2a8b0c95a7a585c4407c330c5f6c
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FRAS1 SDK2 IGSF10 CDH11 CDH13 PCOLCE	5.80e-05	200	149	6	dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	E2F7 CDH23 FREM2 CSPG4 HELZ2 ARRDC2	5.80e-05	200	149	6	be1abe5bb1ce4e7dfec63af4ed0fc5b96bf77866
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_DCN\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	METTL4 ZNF2 IGSF10 HMCN2 CPXM1	9.79e-05	137	149	5	a69976938d4e89315ec0be3a332b91ddf3799d65
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DSCAM IDO2 FREM2 CSPG4 CDH11	1.20e-04	143	149	5	27e06327f96cb72bd111ea6ece6307e5ebb3a146
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-hematologic-hematopoietic_progenitor\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DSCAM IDO2 FREM2 CSPG4 CDH11	1.20e-04	143	149	5	4edef95ae2a1ef4fc4b0d4fadf75bfc54b583932
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-hematologic\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DSCAM IDO2 FREM2 CSPG4 CDH11	1.32e-04	146	149	5	03a6a442f1f6d173a41aeebbfe41ee08853d9585
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF777 ESYT1 CIT XYLB ZNF839	1.50e-04	150	149	5	6f7087a051a2f05c5611ff65a945c01736d5ec2b
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-9\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SDK2 PLPP5 PTPRK PCDH9 TREML2	1.55e-04	151	149	5	2314c004434aed9b7fa1ad01c61c43e5ed4a18ce
ToppCell	Adult-Immune-enucleated_erythrocyte-D175\|Adult / Lineage, Cell type, age group and donor	EDC4 IDO2 HMCN2 CHD5 ALPK2	1.59e-04	152	149	5	530d5427d8617dcb223d807b73abee0ef89285f3
ToppCell	facs-Marrow-KLS-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM PRX C2orf72 PTPRK IL2RB	1.69e-04	154	149	5	37765512dfae557b9f6eb30a29463b93682a4404
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM PRX C2orf72 PTPRK IL2RB	1.75e-04	155	149	5	c58a5fb8d853f12204e961d633e83452eb12a659
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5\|390C / Donor, Lineage, Cell class and subclass (all cells)	LRP12 GTF2H3 XYLB KIF18B ENO3	1.75e-04	155	149	5	afdd0aba0f3788c2fb916ffb453c5dd7cde2304c
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM PRX C2orf72 PTPRK IL2RB	1.75e-04	155	149	5	9cb8c42c2e451b2d4dcd7154a4b1bfd21bbb7ea8
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR2F6 MAZ FREM2 GIGYF2 ENO3	1.91e-04	158	149	5	b0508a600994090c6aafd8d779437190a33ad821
ToppCell	facs-Lung-EPCAM-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR2F6 MAZ FREM2 GIGYF2 ENO3	1.91e-04	158	149	5	a816cc095452308d06f87b77467e2a8c6361fd2a
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	SDK2 REXO5 CDH11 CDH13 PCOLCE	1.96e-04	159	149	5	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FRAS1 FREM2 KIAA1549L MYPN ROS1	2.14e-04	162	149	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	HECTD4 FREM2 PTPRK ROS1 ZNF518B	2.14e-04	162	149	5	2259e9536147e9cdee772e3a30ba7d104573262c
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LRRN4CL MYPN SLIT1 MYBPC2 PCOLCE	2.14e-04	162	149	5	56f1789e69a6cb29956e46aba92b290847327c1f
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SPEG MEGF6 MOCS3 CHD5 CDH13	2.20e-04	163	149	5	51dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCell	Adult-Mesenchymal-chondrocyte-D231\|Adult / Lineage, Cell type, age group and donor	SDK2 REXO5 CDH11 CDH13 PCOLCE	2.27e-04	164	149	5	2ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCell	facs-Kidney-nan-3m-Lymphocytic\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESYT1 FAM228A ARHGEF1 KIF18B IL2RB	2.33e-04	165	149	5	ba041deb0d9c187f251493ccd4794b5f09abd5aa
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	HECTD4 FREM2 PTPRK ROS1 ZNF518B	2.40e-04	166	149	5	89e2b8453180983533faccb4275867861876d7ee
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	ADAMTSL1 SPEG HMCN2 IL2RB CDH13	2.47e-04	167	149	5	c4e321bb87512ea839f324c92c0f1afea891483f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	OGT ELMO2 SLIT1 ANKRD17 KIF17	2.47e-04	167	149	5	ced6ed9b412739c6ced622523347c10295edbf53
ToppCell	droplet-Thymus-nan-21m-Myeloid-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR2F6 IFNLR1 RUSC2 ALPK2 MYBPC2	2.54e-04	168	149	5	69dd747be46e7fbcec571cddd6dee374b9c2507a
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	LRP12 GTF2H3 XYLB KIF18B ENO3	2.54e-04	168	149	5	d7d19c93d1c3dd994e18e28d5f36ae7773ff5d7f
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ABAT CDH23 PRX LRP3 CDH11	2.54e-04	168	149	5	8459d0a1bf6d4b5c83001097331f8b78fceb9305
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFNLR1 KIAA1549L MEGF6 RPE65 CDH11	2.54e-04	168	149	5	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTSL1 SDK2 SLIT1 SEMA4A CDH11	2.54e-04	168	149	5	7abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFNLR1 KIAA1549L MEGF6 RPE65 CDH11	2.54e-04	168	149	5	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LRP12 GTF2H3 XYLB KIF18B ENO3	2.61e-04	169	149	5	d2def7229fe9d6b0c70cfed349ede491c8c137a0
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SPEG SHANK3 HMCN2 KIAA1549L CDH13	2.61e-04	169	149	5	c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-ABC_aged-B_naive\|bone_marrow / Manually curated celltypes from each tissue	SDK2 PTPRK PCDH9 ALPK2 TREML2	2.75e-04	171	149	5	fcc31a9a69f96de10d1324a5a4fbfe4289bf4984
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	ARHGAP22 WNT10A CPXM1 SEMA4A IL2RB	2.83e-04	172	149	5	58eaadf12366701103a0d1f133462c9495fedc30
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FRAS1 ARHGAP22 FREM2 LRRN4CL PCOLCE	2.83e-04	172	149	5	9a256db817c1af1802203cc88a55d608fb328c63
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	ARHGAP22 WNT10A CPXM1 SEMA4A IL2RB	2.83e-04	172	149	5	4483073469001770015526303772fd54906c5d68
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CIT ZNF8 HELZ2 MASTL KIF18B	2.83e-04	172	149	5	2b6cd84c946b1e800caba452ae70145ea285fec1
ToppCell	367C-Myeloid-Dendritic-cDC_activated\|367C / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP22 IDO2 ENO3 ALPK2 MYBPC2	2.90e-04	173	149	5	94f99f7e7813d6e53e0bedf97087400b1bf00129
ToppCell	wk_15-18-Hematologic-Myeloid-pDC\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	RPS6KA4 IFNLR1 WNT10A KIF17 TREML2	2.90e-04	173	149	5	b571970e3ba88afc07041c5692ccfd85fc39e796
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABAT CHD5 CSPG4 WNT10A CDH3	2.98e-04	174	149	5	a7ade7372e83edd4e3983e77f8417b51f0b47340
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRX FREM2 RPAP1 LRP3 PCDH9	2.98e-04	174	149	5	c58328c2f262506a4518f49f148e29874faf9171
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLPP5 PKD1L3 NACC2 SLIT1 WNT10A	2.98e-04	174	149	5	3f4277763e312b46ebd4401ea4a2f5d4c850c768
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTSL1 SDK2 ROS1 SEMA4A CDH11	2.98e-04	174	149	5	e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SDK2 DCBLD1 ARHGAP22 ROS1 CDH11	2.98e-04	174	149	5	7d4b860e05b5931f6f9d757a68f75ff35597a47a
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FREM2 LRRN4CL MEGF6 KIF17 MYBPC2	2.98e-04	174	149	5	4da79da7a09ee1e345102c5331675ebcdbe56171
ToppCell	droplet-Lung-nan-21m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLPP5 PKD1L3 NACC2 SLIT1 WNT10A	2.98e-04	174	149	5	fad66d1a8407574b6a835e0bdb824a53afa58650
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTSL1 SDK2 SLIT1 SEMA4A CDH11	3.06e-04	175	149	5	90e29945aa861082c94bb4f331161adc3a6ef899
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLPP5 PKD1L3 NACC2 SLIT1 WNT10A	3.06e-04	175	149	5	28b29f844fa46fe579ddc19039fb2d9dc5f48f3b
ToppCell	facs-Marrow-T-cells-24m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLPP5 TRIM31 CDH23 NACC2 WNT10A	3.06e-04	175	149	5	0a01e0104cfa3091bc05b0f1d087c941688169a5
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-plasma_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLPP5 PKD1L3 NACC2 SLIT1 WNT10A	3.06e-04	175	149	5	ac96ca9ca309b0d72a2f5af6a3b02c7f80755750
ToppCell	pdx-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SHLD2 TUT4 KIAA0319L XYLB CDH1	3.14e-04	176	149	5	1e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
Drug	Hyoscyamine (L) [101-31-5]; Down 200; 13.8uM; PC3; HT_HG-U133A	EGLN2 LRP12 REXO5 ASTE1 RBM42 RUSC2 GTF2H3 PHACTR4 ZNF839 CDH1	4.71e-07	196	143	10	2108_DN
Drug	(d,l)-Tetrahydroberberine [522-97-4]; Up 200; 11.8uM; MCF7; HT_HG-U133A	HDAC11 LRP12 SZT2 KIAA0319L MGAT2 RPAP1 AMOT XYLB CDH11	4.27e-06	196	143	9	2818_UP
Drug	3-Acetylcoumarin [3949-36-8]; Up 200; 21.2uM; MCF7; HT_HG-U133A	SZT2 RUSC2 MGAT2 OVGP1 MEGF6 XYLB IL2RB GGA1 CDH11	4.45e-06	197	143	9	3382_UP
Disease	Agouti-related protein measurement	RIPOR1 CDH1 CDH3 CDH15	7.18e-06	27	137	4	EFO_0008016
Disease	fibrinogen measurement, factor VII measurement	HECTD4 PKD1L3 SHANK3 SPPL2A HDLBP	7.54e-06	58	137	5	EFO_0004619, EFO_0004623
Disease	venous thromboembolism, fibrinogen measurement	HECTD4 SHANK3 SPPL2A SBNO1 HDLBP	1.54e-05	67	137	5	EFO_0004286, EFO_0004623
Disease	Cryptophthalmos syndrome	FRAS1 FREM2	6.40e-05	3	137	2	C0265233
Disease	FRASER SYNDROME 1	FRAS1 FREM2	6.40e-05	3	137	2	C4551480
Disease	Hepatic fibrosis	SDK2 KIAA1549L CDH3 CDH15	8.01e-05	49	137	4	HP_0001395
Disease	Ischemic stroke, fibrinogen measurement	HECTD4 SHANK3 SPPL2A HDLBP	1.26e-04	55	137	4	EFO_0004623, HP_0002140
Disease	Fraser syndrome (implicated_via_orthology)	FRAS1 FREM2	1.28e-04	4	137	2	DOID:0090001 (implicated_via_orthology)
Disease	psoriasis	KCNH7 RPS6KA4 SPATA31C2 IFNLR1 RUSC2 MYPN SLIT1	2.97e-04	273	137	7	EFO_0000676
Disease	Disorder of eye	FRAS1 CDH23 FREM2 SEMA4A RPE65 CDH3	4.82e-04	212	137	6	C0015397
Disease	Unilateral agenesis of kidney	FRAS1 FREM2	5.88e-04	8	137	2	C0266294
Disease	ulcerative colitis	LRP12 RPS6KA4 CIT RLN2 SLIT1 CDH3 CDH15	9.97e-04	335	137	7	EFO_0000729
Disease	fibrinogen measurement, tissue plasminogen activator measurement	HECTD4 PKD1L3 SPPL2A	1.20e-03	45	137	3	EFO_0004623, EFO_0004791
Disease	fibrinogen measurement, plasminogen activator inhibitor 1 measurement	HECTD4 PKD1L3 SPPL2A	1.20e-03	45	137	3	EFO_0004623, EFO_0004792
Disease	myocardial infarction	HECTD4 DCBLD1 LAMB2 PKD1L3 GIGYF2 CDH13 HTT	1.28e-03	350	137	7	EFO_0000612
Disease	neuroticism measurement, cognitive function measurement	DSCAM PCDHA13 PCDHA6 PKD1L3 PTPRK PCDH9 CDH13 PROX1 MYBPC2	1.35e-03	566	137	9	EFO_0007660, EFO_0008354
Disease	chronic obstructive pulmonary disease	FRAS1 ADAMTSL1 SPEG TRIM31 METTL4 SPPL2A RPAP1 MEGF6 MYPN HDLBP	1.44e-03	688	137	10	EFO_0000341
Disease	fibrinogen measurement	PKD1L3 SHANK3 SPPL2A HDLBP	1.70e-03	109	137	4	EFO_0004623
Disease	Pneumoconiosis	CDH23 OVGP1	1.88e-03	14	137	2	C0032273
Disease	Bagassosis	CDH23 OVGP1	1.88e-03	14	137	2	C0004681
Disease	thyroid gland papillary carcinoma (is_marker_for)	CBX7 CDH1	1.88e-03	14	137	2	DOID:3969 (is_marker_for)
Disease	unipolar depression, cognitive function measurement	CPXM1 ZNF839	2.16e-03	15	137	2	EFO_0003761, EFO_0008354
Disease	serum urea measurement	SPPL2A CSPG4 SEMA4A GNAS PROX1	2.21e-03	195	137	5	EFO_0009795
Disease	polyp of colon	CDH1 CDH3 CDH15	2.27e-03	56	137	3	MONDO_0021400
Disease	factor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement	HECTD4 PKD1L3 SPPL2A	2.27e-03	56	137	3	EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Disease	lysosomal storage disease (implicated_via_orthology)	PSAPL1 GGA1	2.46e-03	16	137	2	DOID:3211 (implicated_via_orthology)
Disease	Hallux valgus	DSCAM ARHGEF1 SLIT1	2.76e-03	60	137	3	HP_0001822
Disease	SARS-CoV-2 antibody measurement, response to COVID-19 vaccine	DSCAM ARRDC2 CDH13	3.03e-03	62	137	3	EFO_0803360, EFO_0803362
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	SEMA4A CDH1	3.47e-03	19	137	2	C1333991
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	SEMA4A CDH1	3.47e-03	19	137	2	C2936783
Disease	hearing loss	CDH23 PTPRK UTP15	3.78e-03	67	137	3	EFO_0004238
Disease	schizophrenia (implicated_via_orthology)	SHANK3 SBNO1 GIGYF2	3.94e-03	68	137	3	DOID:5419 (implicated_via_orthology)
Disease	neutrophil count, basophil count	HECTD4 PCDHA13 PCDHA6 SPPL2A NCOA1	4.01e-03	224	137	5	EFO_0004833, EFO_0005090
Disease	Vertigo	LRP12 SDK2 CDH23 SPPL2A	4.08e-03	139	137	4	HP_0002321
Disease	myeloid white cell count	FKBP15 HECTD4 CDH23 CIT PRX SPPL2A CBX7 PKN2 GGA1 HTT TREML2	4.40e-03	937	137	11	EFO_0007988

Protein segments in the cluster

Peptide	Gene	Start	Entry
ARVPALEPFRVEQAP	ALKBH6	6	Q3KRA9
TVPPFVDPLFQRQQE	FAM228A	56	Q86W67
PLVPDLQDVAQLRSP	ESYT1	311	Q9BSJ8
QPVPADPFAIVSRAQ	AMOT	421	Q4VCS5
RVPVPPNVAFELDRT	ARHGEF1	111	Q92888
DPDAPVLTNVLLVVP	CSPG4	896	Q6UVK1
FAITVRDVNERPPQP	CSPG4	1821	Q6UVK1
RLARPAEPPFQALVE	C2orf72	11	A6NCS6
PRQPLEVQALPAALD	CHD5	1586	Q8TDI0
IIPIFLIHRPENNIP	ALPK2	2011	Q86TB3
EIQRFPVPAVEPVPA	C2orf27A	16	P0DPF5
VNRIAVPKPPSIEEF	MASTL	21	Q96GX5
PPVIFLPNFLVQRKV	HDAC11	96	Q96DB2
AEIQRFPVPAVEPVP	CDRT15P3	21	P0DPF6
EQNFEPIRRQSLTPP	ANKRD13C	401	Q8N6S4
ELQRQEPSVEPPFAL	CAMTA2	811	O94983
ETPVLNLLPEPQVAR	CPXM1	236	Q96SM3
VNLQVERPFLVLPPL	BTBD11	491	A6QL63
ITPENVQIIFDDPLP	ANKRD17	1576	O75179
VVSPILIPENQRQPF	CDH13	141	P55290
VIDVNDNRPVFVRPP	CDH23	2601	Q9H251
LPAQPDISPNIFEAV	CIT	1671	O14578
VIEPVDINTPALLAP	ARRDC2	151	Q8TBH0
PPQPLAFSEVERINK	ASTE1	396	Q2TB18
QVPAAPVIRPIIATN	RBM42	76	Q9BTD8
PFFPELPVADQVALL	NR2F6	221	P10588
VLPPESFVVLHRPNQ	PCOLCE	411	Q15113
PRPVAEIVPSFINKD	RLN2	66	P04090
IRFQPQLNPDVVAPL	EDC4	521	Q6P2E9
VEVRDINDNPPLFPV	PCDHA6	121	Q9UN73
EDPQVFNTLFPSRPI	KIAA1549	476	Q9HCM3
IARQLGVPLEPVNFP	FBXO21	311	O94952
QQVPIFPQPLITDRA	FASTK	381	Q14296
PQLSLQPEPVFTVDR	PAQR7	21	Q86WK9
NPPPVIAFADLITVD	FRAS1	1831	Q86XX4
LVPRAQPLAPQDFEE	LRRN4CL	16	Q8ND94
QLIAQGLIPPVEDFP	LRP12	551	Q9Y561
FEVEPAPPVLVLTQT	IFNLR1	121	Q8IU57
VPAVPQPEADNLTLR	MGAT2	76	Q10469
GPQLLPVRALNEVFI	NADK2	266	Q4G0N4
RPPIAIVSPQFQEIS	KIAA0319L	406	Q8IZA0
ENAATPERVNPILPI	KCNH7	136	Q9NS40
TLQVQVPPVLEPVEF	HMCN2	3406	Q8NDA2
QFLFPITLVPVDDQP	FREM2	546	Q5SZK8
VNRPALGILPPENFV	ABAT	126	P80404
LPPNVCPVLREFRVE	FER1L4	926	A9Z1Z3
GAALPPNVQIIPVFV	HPS4	236	Q9NQG7
LDPPQVPTQLEDIRA	ADAMTSL1	1371	Q8N6G6
PAEVLPRNLALPFVE	IDO2	116	Q6ZQW0
PPIFNQPVIELSVSE	PCDH9	466	Q9HC56
QVVEEAVPLPPQALT	FKBP15	986	Q5T1M5
LFLPEFPIRPIRGQQ	RSKR	91	Q96LW2
LIAQGLIPPVEDFPV	LRP3	556	O75074
PAAEPLQVDLLPVLA	MAZ	76	P56270
AELELIVQRPGPVPA	LAMB2	636	P55268
APQPIRNIVFQSAVP	GGA1	551	Q9UJY5
QETVVLPLPIRDAPQ	KIAA1549L	1251	Q6ZVL6
FPPRIGPVAQDLLQR	RPS6KA4	261	O75676
ARPQFRPSIKEVIQP	HECTD4	886	Q9Y4D8
PQELSRLDQPFIPRA	KIF18B	746	Q86Y91
FQVVPEIEFPPSLDL	PHACTR4	366	Q8IZ21
VKVRDINDNPPIFPE	PCDHA13	121	Q9Y5I0
ALELLQQLFRTPPPE	HTT	376	P42858
IPDSIPPNVERINLG	IGSF10	51	Q6WRI0
VLPPLVDVIPEARLN	TTC26	276	A0AVF1
PITPVKFVDRQQAEP	E2F7	66	Q96AV8
LPPLALVPFTEEEQR	GIGYF2	76	Q6Y7W6
IQIAFEEVPQLPPRA	C2CD2L	121	O14523
FQSPPIVELREKIQP	ELMO2	521	Q96JJ3
LTADVQVFPRPEPFV	INTS14	221	Q96SY0
DLVDFQPPPELVLRE	IL2RB	481	P14784
ELFLQEPPAPDVLQA	CBX7	171	O95931
NRPLEPPSEFIVKVQ	CDH11	136	P55287
PISIQLFPPELVEHI	FBXO24	36	O75426
TPNPRLQNFVPIDLD	MCRIP2	131	Q9BUT9
PQLRPDPVILQSADL	MARF1	1636	Q9Y4F3
PDLILPVPAFNVING	ENO3	141	P13929
AVAAPQLPVLEVQPL	E4F1	406	Q66K89
LLQIFPEGRPVVANI	EGLN2	326	Q96KS0
RDPVQNNFIPPIVAR	DCBLD1	376	Q8N8Z6
APVPAPDNTVFEVRL	HELZ2	421	Q9BYK8
TEPETLIPLVQFPQA	HELZ2	2366	Q9BYK8
SEQVPLFRDPLQPQF	ERVFC1	286	P60507
VIRAPRIASFPQPQV	SDK2	131	Q58EX2
QVVRQLEAEPGLPPV	SCO2	146	O43819
EPETVPTPALLNVRQ	SBNO1	66	A3KN83
EPPVFQENPLRTSLA	CDH15	371	P55291
PEVVLRNDVAPTIIP	CDH3	726	P22223
LPLRNADVNVLPIPD	METTL4	391	Q8N3J2
ALLAEQEPQPERLVP	MOCS3	31	O95396
NEAPIFVPPEKRVEV	CDH1	481	P12830
SNFAQLIVREPPRPI	PTPRK	281	Q15262
PQNRIIFSPVAPKEE	OGT	896	O15294
PEQTPLAFDNRFVPI	OVGP1	631	Q12889
LLSRQVPPDPVQVEE	KIF17	376	Q9P2E2
EAQAPVALVAQPEPL	KIF17	696	Q9P2E2
PFVRPLPHIAVLQDE	MEGF6	466	O75095
VRVPPKFVVQPRDQD	DSCAM	686	O60469
EQRPTTLPIQPFVFQ	RUSC2	686	Q8N2Y8
SPDPIIPQNVIHFIL	RTL1	706	A6NKG5
SLTVVFREPFPVQPQ	SZT2	3386	Q5T011
QPRFAPVLINAAEII	UTP15	431	Q8TED0
PQPEVRRYVLPLNID	RPE65	361	Q16518
RSEEFQFLNPTPVPL	TRIM31	256	Q9BZY9
FFVPADQALRLLPPQ	PSAPL1	231	Q6NUJ1
LDVSPAPQTERNIPF	TREML2	121	Q5T2D2
PPIIFEASVDLVQIP	TAPBPL	91	Q9BX59
PQERLTSILPENFPV	SPATA31C2	431	B4DYI2
PRPVAEIVPSFINKD	RLN1	66	P04808
LPENFPVSPELRRQL	SPATA31A6	581	Q5VVP1
LDVLSERFPPQQATP	NCOA1	966	Q15788
LVPPVELANPENQFR	GNAS	756	Q5JWF2
QVFPPLQIPQARFAV	PROX1	381	Q92786
PENFPVSPELRRQLE	SPATA31A7	586	Q8IWB4
VPRVRVPPNVLYEDL	FAM90A26	436	D6RGX4
LVEEIQLFPDPEPVR	SEMA4A	456	Q9H3S1
QLFPDPEPVRNLQLA	SEMA4A	461	Q9H3S1
NLVIGRLFPLIEPQE	PKD1L3	961	Q7Z443
LPPRQPQRVNSIDFV	SHLD2	571	Q86V20
VALLQDVRAEQPSPP	SPINDOC	136	Q9BUA3
VVDVRIPQLAPPASD	PKN2	546	Q16513
PQTIRFQPTVEERPL	SPEM1	176	Q8N4L4
VFGPNILRPQVEDPV	ARHGAP22	311	Q7Z5H3
FLVTQPPLQAPEFIL	ANHX	306	E9PGG2
REVLNAVPVLPHIPA	CYP2D7	221	A0A087X1C5
PENFPVSPELRRQLE	SPATA31A3	586	Q5VYP0
VSLGLPVPQPDVIFQ	ZNF2	51	Q9BSG1
PEVAAQLPAVRQLLP	ZSWIM9	296	Q86XI8
PENFPVSPELRRQLE	SPATA31A1	586	Q5TZJ5
APVFEIPLQNVVVAP	SPEG	721	Q15772
PENFPVSPELRRQLE	SPATA31A5	586	Q5VU36
EPELVFAVNLPPAQL	SHANK3	1276	Q9BYB0
RVVPPPFEQEALQTL	REXO5	696	Q96IC2
EVAVPEVRLPEVQLP	PRX	561	Q9BXM0
PFGNNEKLPVVIRVP	SPPL2A	376	Q8TCT8
DVPFSEVVKLAPNPR	XYLB	486	O75191
VTELLPPFQRLIQPE	PLPP5	26	Q8NEB5
ALIPETPLRQSEFPN	ROS1	1601	P08922
RIIAEAPQELALPPE	RPAP1	651	Q9BWH6
EAQPLFPPVRQIVLE	TET3	616	O43151
FVQRPLPALQVVPAK	ZNF839	61	A8K0R7
VPPQQLVPCFQVTLR	ZACN	211	Q401N2
PPAARLQEPVTFRDV	ZNF8	16	P17098
INIPPPSVNRTEIVF	HDLBP	256	Q00341
DLRLPPEPVLNANTV	WNT10A	46	Q9GZT5
FVPFVDEQQPTEIPI	ITFG1	316	Q8TB96
PVVPANEPSLRELVQ	ZNF629	126	Q9UEG4
FPSVPQEETLRQAPA	ZNF777	11	Q9ULD5
PDFLRQIPLQDVAFP	SLIT1	701	O75093
NDPSIIFAQPAARPV	TUT4	1526	Q5TAX3
PEPLPIQVAFRRPET	RIPOR1	411	Q6ZS17
FLPDQDQRSQLILPP	GTF2H3	231	Q13889
QLIKPVPFCPVRQAD	ZNF518B	806	Q9C0D4
PAVAPDFVPFVQLRP	KIAA2013	116	Q8IYS2
PEFPPAAAQVFEQRI	NACC2	481	Q96BF6
IFLQVVDVPDPPEAV	MYBPC2	631	Q14324
VPIPIPADTRDNEVN	MYPN	211	Q86TC9