Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainPH_dom-like

SPTBN4 SPTBN5 RANBP2 PTPN13 PLEKHG7 OSBPL3 FARP1 FRMD7 OSBPL11 TNS2 LRBA RASAL2

4.97e-074268512IPR011993
Domain-

SPTBN4 SPTBN5 RANBP2 PTPN13 PLEKHG7 OSBPL3 FARP1 FRMD7 OSBPL11 TNS2 RASAL2

1.57e-0639185112.30.29.30
Domain-

DCAF13 RAE1 IFT172 DTL APAF1 CDC20B SMU1 SEMA5A LRBA

2.05e-053338592.130.10.10
DomainWD40/YVTN_repeat-like_dom

DCAF13 RAE1 IFT172 DTL APAF1 CDC20B SMU1 SEMA5A LRBA

2.15e-05335859IPR015943
DomainWD40

DCAF13 RAE1 IFT172 DTL APAF1 CDC20B SMU1 LRBA

2.35e-05259858PF00400
DomainWD40

DCAF13 RAE1 IFT172 DTL APAF1 CDC20B SMU1 LRBA

3.00e-05268858SM00320
DomainWD40_repeat

DCAF13 RAE1 IFT172 DTL APAF1 CDC20B SMU1 LRBA

3.33e-05272858IPR001680
DomainWD_REPEATS_1

DCAF13 RAE1 IFT172 DTL APAF1 CDC20B SMU1 LRBA

3.89e-05278858PS00678
DomainWD_REPEATS_2

DCAF13 RAE1 IFT172 DTL APAF1 CDC20B SMU1 LRBA

3.99e-05279858PS50082
DomainWD_REPEATS_REGION

DCAF13 RAE1 IFT172 DTL APAF1 CDC20B SMU1 LRBA

3.99e-05279858PS50294
DomainWD40_repeat_dom

DCAF13 RAE1 IFT172 DTL APAF1 CDC20B SMU1 LRBA

6.20e-05297858IPR017986
DomainWD40_repeat_CS

DCAF13 RAE1 DTL APAF1 CDC20B SMU1

1.03e-04164856IPR019775
DomainKIND_dom

PTPN13 SPIRE1

2.03e-045852IPR011019
DomainKIND

PTPN13 SPIRE1

2.03e-045852SM00750
DomainKIND

PTPN13 SPIRE1

2.03e-045852PS51377
DomainFERM_C

PTPN13 FARP1 FRMD7

2.19e-0426853PF09380
DomainFERM_C

PTPN13 FARP1 FRMD7

2.46e-0427853SM01196
DomainFERM_PH-like_C

PTPN13 FARP1 FRMD7

2.46e-0427853IPR018980
DomainPH

SPTBN4 SPTBN5 PLEKHG7 OSBPL3 FARP1 OSBPL11 RASAL2

2.75e-04278857SM00233
DomainPH_DOMAIN

SPTBN4 SPTBN5 PLEKHG7 OSBPL3 FARP1 OSBPL11 RASAL2

2.81e-04279857PS50003
DomainPH_domain

SPTBN4 SPTBN5 PLEKHG7 OSBPL3 FARP1 OSBPL11 RASAL2

2.88e-04280857IPR001849
DomainFERM_N

PTPN13 FARP1 FRMD7

4.50e-0433853PF09379
DomainFERM_N

PTPN13 FARP1 FRMD7

4.50e-0433853IPR018979
DomainPH_dom-spectrin-type

SPTBN4 SPTBN5

7.22e-049852IPR001605
DomainARM-type_fold

AP4E1 BZW2 IFT172 PRKDC LRBA TRIP12 TBCD

8.96e-04339857IPR016024
DomainFERM_M

PTPN13 FARP1 FRMD7

1.20e-0346853PF00373
DomainOxysterol-bd

OSBPL3 OSBPL11

1.31e-0312852IPR000648
DomainOxysterol-bd_CS

OSBPL3 OSBPL11

1.31e-0312852IPR018494
DomainOxysterol_BP

OSBPL3 OSBPL11

1.31e-0312852PF01237
DomainOSBP

OSBPL3 OSBPL11

1.31e-0312852PS01013
Domain-

PTPN13 FARP1 FRMD7

1.44e-03498531.20.80.10
DomainFERM_central

PTPN13 FARP1 FRMD7

1.44e-0349853IPR019748
DomainFERM_domain

PTPN13 FARP1 FRMD7

1.44e-0349853IPR000299
DomainFERM_1

PTPN13 FARP1 FRMD7

1.53e-0350853PS00660
DomainFERM_2

PTPN13 FARP1 FRMD7

1.53e-0350853PS00661
DomainFERM_3

PTPN13 FARP1 FRMD7

1.53e-0350853PS50057
DomainKAZAL_2

SLCO1B3 SPOCK2 CFI

1.53e-0350853PS51465
DomainBand_41_domain

PTPN13 FARP1 FRMD7

1.53e-0350853IPR019749
DomainB41

PTPN13 FARP1 FRMD7

1.53e-0350853SM00295
DomainFERM/acyl-CoA-bd_prot_3-hlx

PTPN13 FARP1 FRMD7

1.53e-0350853IPR014352
DomainFERM-adjacent

FARP1 FRMD7

1.55e-0313852IPR014847
DomainFA

FARP1 FRMD7

1.55e-0313852SM01195
DomainFA

FARP1 FRMD7

1.55e-0313852PF08736
DomainKazal_dom

SLCO1B3 SPOCK2 CFI

1.62e-0351853IPR002350
DomainTSP_1

SPON1 ISM1 SEMA5A

2.97e-0363853PF00090
DomainCation_ATPase_N

ATP2C2 ATP13A5

2.99e-0318852PF00690
DomainCation_ATPase_N

ATP2C2 ATP13A5

2.99e-0318852SM00831
DomainTSP1

SPON1 ISM1 SEMA5A

3.24e-0365853SM00209
DomainTSP1_rpt

SPON1 ISM1 SEMA5A

3.24e-0365853IPR000884
DomainTSP1

SPON1 ISM1 SEMA5A

3.24e-0365853PS50092
DomainATPase_P-typ_cation-transptr_N

ATP2C2 ATP13A5

3.33e-0319852IPR004014
Domain-

AP4E1 PRKDC LRBA TRIP12 TBCD

3.44e-032228551.25.10.10
DomainPH

SPTBN4 SPTBN5 OSBPL3 FARP1 OSBPL11

3.93e-03229855PF00169
DomainCH

SPTBN4 SPTBN5 CFAP47

4.00e-0370853PF00307
DomainEz/rad/moesin-like

FARP1 FRMD7

4.06e-0321852IPR000798
Domain-

SPTBN4 SPTBN5 CFAP47

4.16e-03718531.10.418.10
DomainCH

SPTBN4 SPTBN5 CFAP47

4.50e-0373853PS50021
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

RANBP2 TRMT10C HSPA4L BZW2 OSBPL3 FANCI IFT172 DTL SMU1 LRP1 GEMIN4 TNS2 PRKDC

1.04e-06974881328675297
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RANBP2 PTPN13 ALMS1 LRP1 GEMIN4 KIF14 ZDBF2 LRBA NXF1

1.19e-0641888934709266
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

CFAP47 ALMS1 NLRP7 FANCI FARP1 TRAPPC6B TRIP12 PROC

1.83e-0632688817015433
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

RANBP2 DCAF13 CHERP FANCI SMU1 GEMIN4 KIF14 PRKDC TRIP12 NXF1

6.16e-06653881022586326
Pubmed

The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.

RANBP2 RAE1 NXF1

1.04e-051788310668806
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

AP4E1 PTPN13 FANCI PRKDC TRIP12 GPR151 TBCD

1.83e-0532288726514267
Pubmed

Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients.

SLC30A8 LRP1

1.90e-05388224423473
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

RANBP2 CHERP HSPA4L FANCI IFT172 SMU1 GEMIN4 PRKDC LRBA

3.50e-0563888933239621
Pubmed

RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export.

RANBP2 NXF1

3.79e-05488214729961
Pubmed

Interleukin 1 participates in the development of anti-Listeria responses in normal and SCID mice.

SPTBN4 PRKDC

3.79e-0548821531270
Pubmed

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.

PRKDC TDP1

3.79e-05488219851285
Pubmed

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.

PRKDC TDP1

3.79e-05488212023295
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

HSPA4L FARP1 APAF1 GEMIN4 TRIP12 AKR1C2 NXF1 TBCD

3.94e-0549888836634849
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

SPTBN4 RAP2B FARP1 LRP1 BTBD9 RASAL2

4.40e-0525188627507650
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

SUPT3H TRMT10C USP17L2 RAE1 FANCI DTL SMU1 LRP1 OSBPL11 BTBD9 TRIP12

4.67e-051005881119615732
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

AP4E1 RANBP2 PTPN13 ALMS1 LRBA RASAL2

5.70e-0526388634702444
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

RANBP2 TRMT10C DCAF13 CHERP HSPA4L FANCI SMU1 GEMIN4 KIF14 PRKDC TTC3 NXF1 RASAL2

5.97e-051425881330948266
Pubmed

OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype.

OSBPL3 OSBPL11

6.30e-05588223028956
Pubmed

Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth.

SPC25 PRKDC

6.30e-05588227197203
Pubmed

Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex.

RANBP2 NXF1

6.30e-05588216314397
Pubmed

Activated protein C decreases tumor necrosis factor related apoptosis-inducing ligand by an EPCR- independent mechanism involving Egr-1/Erk-1/2 activation.

TNFSF10 PROC

6.30e-05588217932312
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

RANBP2 PTPN13 HSPA4L BZW2 FANCI GEMIN4 PRKDC LRBA RASAL2

7.79e-0570888939231216
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

RANBP2 TRMT10C PTPN13 CHERP RAE1 FARP1 SMU1 SPOCK2 PRKDC TRIP12 NXF1

9.02e-051082881138697112
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

RANBP2 IGHA1 HSPA4L BZW2 OSBPL3 FANCI GEMIN4 SPIRE1 SNRK LRBA PKD1L3 RASAL2

9.40e-051284881217353931
Pubmed

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.

PRKDC PROC

9.43e-05688228827518
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

HARS2 RANBP2 SUPT3H TRMT10C PTPN13 RAP2B FARP1 SMU1 GEMIN4 KIF14 SPIRE1 TAF1L NXF1

9.81e-051497881331527615
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

RANBP2 CHERP RAE1 HSPA4L FARP1 SMU1 ZDBF2 PRKDC

1.18e-0458388829844126
Pubmed

NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery.

RAE1 ULBP3

1.32e-04788225583577
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

RANBP2 RAE1 HSPA4L BZW2 FANCI DTL GEMIN4 PRKDC TRIP12 TBCD

1.36e-04942881031073040
Pubmed

Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.

RANBP2 RAE1 NXF1

1.45e-044088337516964
Pubmed

Interactome of the Autoimmune Risk Protein ANKRD55.

RANBP2 FANCI PRKDC LRBA NXF1

1.48e-0419788531620119
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

RANBP2 TRMT10C CHERP IGHA1 SPOCK2 NXF1 HMGB1P1 TBCD

1.55e-0460788839147351
Pubmed

Global landscape of HIV-human protein complexes.

HARS2 RANBP2 ALMS1 OSBPL3 SMU1 GEMIN4 PRKDC

1.64e-0445788722190034
Pubmed

ABCE1 is a highly conserved RNA silencing suppressor.

RAP2B FANCI ULBP3 HMGB1P1 TBCD

1.74e-0420488525659154
Pubmed

Imaging within single NPCs reveals NXF1's role in mRNA export on the cytoplasmic side of the pore.

RANBP2 NXF1

1.75e-04888231375530
Pubmed

A protein interaction landscape of breast cancer.

DCAF13 RAE1 IGHA1 HSPA4L FANCI SMU1 LRP1 MUC5B

2.09e-0463488834591612
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

SPTBN5 FANCI LRP1 TNS2 TBCD

2.18e-0421488522199357
Pubmed

Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.

LRP1 MUC5B AKR1C2

2.34e-044788311208732
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

RANBP2 RAP2B RAE1 FARP1 SMU1 KIF14 PRKDC TRIP12

2.73e-0466088832780723
Pubmed

A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.

FANCI TDP1

2.81e-041088217478428
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

RANBP2 CHERP RAE1 OSBPL3 FARP1 SMU1 GEMIN4 PRKDC TRIP12

2.97e-0484788935850772
Pubmed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

RAE1 HSPA4L BZW2 FANCI DNAH17 CDC37L1

3.27e-0436388625036637
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

SPTBN4 ALMS1 SPOCK2 TRIP12

3.41e-0413088412421765
Pubmed

The OSBP-related protein family in humans.

OSBPL3 OSBPL11

3.43e-041188211483621
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

SPTBN5 HARS2 TRMT10C ALMS1 HSPA4L OSBPL3 DTL GEMIN4 OSBPL11 SPIRE1 ZDBF2 TTC3

3.83e-041496881232877691
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SPTBN4 PTPN13 IFT172 DENND6B LRP1 SPOCK2 PRKDC LRBA TTC3 TRIP12 RASAL2

3.97e-041285881135914814
Pubmed

A family of 12 human genes containing oxysterol-binding domains.

OSBPL3 OSBPL11

4.11e-041288211735225
Pubmed

An oxysterol-binding protein family identified in the mouse.

OSBPL3 OSBPL11

4.11e-041288212215260
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

PTPN13 OSBPL3 FARP1 DTL OSBPL11 SPIRE1 SPOCK2 TTC3 TRIP12 AKR1C2

4.15e-041084881011544199
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

RANBP2 DCAF13 APAF1 SMU1 PRKDC LRBA TRIP12 NXF1

4.20e-0470488829955894
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

RANBP2 DTL KIF14 TRIP12 NXF1

4.44e-0425088533536335
Pubmed

The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.

SLCO1B3 AKR1C2

4.85e-041388211682476
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTBN4 SPTBN5

4.85e-041388218796539
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

PTPN13 ALMS1 SMU1 OSBPL11 KIF14 PRKDC LRBA

4.95e-0454988738280479
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

HARS2 TRMT10C RAE1 OSBPL3 FARP1 SMU1 GEMIN4 TRIP12 AKR1C2 DIRAS2 NXF1

6.81e-041371881136244648
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

RANBP2 CHERP RAE1 FANCI ZDBF2 PRKDC TRIP12 TAF1L HMGB1P1

6.98e-0495488936373674
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

RANBP2 CHERP RAE1 FANCI GEMIN4 PRKDC TRIP12

6.99e-0458288720467437
Pubmed

JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.

RANBP2 PRKDC

7.42e-041688226291670
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SPTBN4 RANBP2 RAP2B OSBPL3 FARP1 LRP1 BTBD9 TTC3 RASAL2

7.46e-0496388928671696
Pubmed

Human colostrum: identification of minor proteins in the aqueous phase by proteomics.

IGHA1 MUC5B CFI CTSH

7.80e-0416288416502470
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

RAE1 BZW2 FANCI TNS2 PRKDC RASAL2

8.15e-0443288623455922
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

SPON1 ISM1 SEMA5A

9.27e-047588320637190
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTBN4 SPTBN5

9.43e-041888212119179
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

PTPN13 ALMS1 RAE1 KIF14 PRKDC RASAL2

9.61e-0444688624255178
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SPTBN4 RANBP2 DCAF13 NLRP7 HSPA4L DTL CAPRIN2 PRKDC TTC3 TRIP12 FBXO15

1.03e-031442881135575683
Pubmed

Protein interaction discovery using parallel analysis of translated ORFs (PLATO).

SLC22A16 DTL OSBPL11

1.04e-037888323503679
Pubmed

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.

RANBP2 ALMS1 IGHA1 KIF14 ULBP3

1.04e-0330288530561431
Pubmed

Functional dynamics of H3K9 methylation during meiotic prophase progression.

PTGDS AKR1C2

1.05e-031988217599069
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

SUPT3H DPP10 FARP1 SLC30A8 SEMA5A SNRK HMGB1P1 RASAL2

1.08e-0381488823251661
Pubmed

Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.

OSBPL3 SMU1 PRKDC HMGB1P1

1.15e-0318088430110629
Pubmed

Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.

IFT172 DNAH17

1.17e-032088221689717
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

AP4E1 SUPT3H OSBPL3 FANCI FRMD7 DNAH17 WNT16 CAPRIN2 SLC30A8 RASAL2

1.18e-031242881030973865
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

PTPN13 CHERP FANCI SMU1 GEMIN4

1.22e-0331388538270169
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

ALMS1 LRP1 KIF14 RASAL2

1.25e-0318488432908313
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

HARS2 TRMT10C DCAF13 SMU1 GEMIN4 KIF14 PRKDC TRIP12 NXF1 RASAL2

1.29e-031257881036526897
Pubmed

DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.

DCAF13 DTL

1.29e-032188230111536
Pubmed

A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.

PTPN13 GEMIN4

1.29e-032188224923560
Pubmed

Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities.

SMU1 PRKDC

1.41e-032288231839203
Pubmed

Myosin-X recruits lamellipodin to filopodia tips.

TRMT10C RAE1 RASAL2

1.52e-038988336861887
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PTPN13 ALMS1 OSBPL3 DTL KIF14 SPIRE1 TRIP12 RASAL2

1.54e-0386188836931259
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

DCAF13 RAE1 SMU1 TRIP12 NXF1

1.58e-0333288525693804
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

CABP7 FARP1 DENND6B PRKDC TTC3

1.58e-0333288537433992
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

RANBP2 SUPT3H CHERP RAE1 OSBPL3 SMU1 PRKDC TRIP12 TAF1L NXF1

1.60e-031294881030804502
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

AP4E1 ZNF510 TDP1 CFI TTC3 IL1RL2 CTSH

1.80e-0368688729987050
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

RANBP2 TRMT10C DCAF13 CHERP RAE1 HSPA4L PRKDC LRBA TRIP12 NXF1

1.83e-031318881030463901
Pubmed

Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.

RANBP2 RAE1

1.83e-032588210601273
Pubmed

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.

GEMIN4 PRKDC

1.83e-032588215385968
Pubmed

PIDD orchestrates translesion DNA synthesis in response to UV irradiation.

FANCI PRKDC

1.83e-032588221415862
Pubmed

VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.

OSBPL3 OSBPL11

1.83e-032588224885147
Pubmed

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

SPTBN4 SPTBN5

1.83e-03258828493579
Pubmed

Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.

RANBP2 RAE1

1.98e-032688212228227
Pubmed

Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.

AKR1C2 DIRAS2

1.98e-032688223892084
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

PTPN13 ALMS1 ZDBF2 RASAL2

1.99e-0320988436779422
Pubmed

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.

RAE1 OSBPL3 SPIRE1

2.24e-0310288315778465
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

SPTBN4 KIF14 PRKDC TRIP12 NXF1

2.27e-0336188526167880
Pubmed

PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.

RANBP2 HSPA4L GEMIN4 PRKDC

2.28e-0321788431685992
Pubmed

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

DTL SMU1

2.29e-032888217041588
Pubmed

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.

SUPT3H ATP2C2

2.29e-032888218839057
Pubmed

Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.

PRKDC CTSH

2.29e-032888235227662
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

PTPN13 FANCI TBCD

2.37e-0310488331240132
GeneFamilyWD repeat domain containing

DCAF13 RAE1 IFT172 DTL APAF1 CDC20B SMU1 LRBA

5.44e-06262678362
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SPTBN4 PLEKHG7 OSBPL3 FARP1 OSBPL11 RASAL2

1.14e-04206676682
GeneFamilyEF-hand domain containing|Spectrins

SPTBN4 SPTBN5

2.81e-0476721113
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

PTPN13 FARP1 FRMD7

8.42e-04506731293
GeneFamilyOxysterol binding proteins|Pleckstrin homology domain containing

OSBPL3 OSBPL11

8.72e-0412672670
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

GEMIN4 LY75 CTSH

8.92e-0451673870
GeneFamilyWD repeat domain containing|DDB1 and CUL4 associated factors

DCAF13 DTL

1.99e-0318672498
CoexpressionAtlasdev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#4_top-relative-expression-ranked_1000

ALMS1 HSPA4L CAPRIN2 PRKDC PHYHIPL

1.03e-0572855gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k4_1000
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_500

SUPT3H ALMS1 HSPA4L FANCI CAPRIN2 KIF14 PRKDC PHYHIPL FBXO15

2.36e-05385859gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_500
CoexpressionAtlasgamma delta T cells, Tgd.vg3+24alo.e17.Th, TCRd+ Vg3+ CD24-, Fetal Thymus, avg-3

PTPN13 TNFSF10 BZW2 OSBPL3 FANCI FARP1 DTL SPC25 KIF14

4.56e-05419859GSM476664_500
CoexpressionAtlasdev gonad_e13.5_M_GermCell_Oct_k-means-cluster#4_top-relative-expression-ranked_1000

ALMS1 HSPA4L CAPRIN2 PRKDC RASAL2

8.03e-05110855gudmap_dev gonad_e13.5_M_GermCell_Oct_k4_1000
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000

SUPT3H DCAF13 ALMS1 HSPA4L FANCI CAPRIN2 KIF14 PRKDC LRBA PHYHIPL FBXO15 RASAL2

1.00e-048208512gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TNFSF10 FARP1 SPON1 DNAH17 SPOCK2 PHYHIPL AKR1C2 PROC

4.51e-091948788ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCellNS-moderate-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ALMS1 FANCI ATP2C2 DTL ISM1 CDC20B SEMA5A

9.42e-08190877250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TNFSF10 FARP1 SPON1 SEMA5A SPOCK2 PHYHIPL PROC

1.05e-07193877ffa1932da2979d7b63dbac32eb5788346a3f5b2a
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP47 HSPA4L FANCI DTL CDC20B KIF14

1.46e-061808760c146e80d55d18b6988dd21b1da635801bd3140c
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP47 HSPA4L FANCI DTL CDC20B KIF14

1.46e-06180876e9af22beae2f3c7fe213b4e19df84abfd2453433
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP47 HSPA4L FANCI DTL CDC20B KIF14

1.46e-0618087611455ba704ac73f69b474845136cfecec6a88349
ToppCellCOVID-19-kidney-PCT-S1|kidney / Disease (COVID-19 only), tissue and cell type

TNFSF10 FARP1 SPON1 SEMA5A PHYHIPL PROC

1.65e-0618487651ed1ebfdef45149541917c66cbacad87072e51f
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l33-52|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FANCI DTL CAPRIN2 SPC25 KIF14 MUC5B

1.71e-0618587647c69500877b851c0c9744f5e1ef2ee0bff99168
ToppCellNS-critical-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FANCI DTL ISM1 CDC20B SLCO1B3 SEMA5A

1.99e-061908767be0f2ff86ca8500a43e0d44e5e292530f9ba0bb
ToppCellmoderate-Epithelial-FOXN4+|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ALMS1 FANCI ATP2C2 DTL CDC20B SEMA5A

2.25e-061948765dffa578149104dda33774361e9e77b227b5f1ce
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SUPT3H SPOCK2 ZNF510 LRBA TTC3 TBCD

2.31e-061958764b9663509cc5e3f409f6d0d37640cb301a827d98
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PTPN13 PLEKHG7 FARP1 ATP2C2 MUC5B AKR1C2

2.31e-06195876e7230a849ea31e6eef9bc6f5468938499450582d
ToppCellCaecum-(1)_T_cell-(18)_cycling_gd_T|Caecum / shred on region, Cell_type, and subtype

FANCI DTL SPC25 CDC20B KIF14 RASAL2

2.53e-0619887664278d8831c81874937e76b561c53928dfc437c5
ToppCellcritical-Epithelial-FOXN4+|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FANCI DTL ISM1 CDC20B SLCO1B3 SEMA5A

2.53e-061988766b160b3d6a2c1b1641c2c7dcec1a7ef38411fec9
ToppCellCaecum-T_cell-cycling_gd_T|Caecum / Region, Cell class and subclass

FANCI DTL SPC25 CDC20B KIF14 RASAL2

2.53e-061988765b719b67f8384863077070e1eb7e04a320e6dab4
ToppCellCaecum-T_cell-cycling_gd_T|T_cell / Region, Cell class and subclass

FANCI DTL SPC25 CDC20B KIF14 RASAL2

2.60e-0619987664d1e495307a91bc012130613126d86e0cf170b0
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPN13 OSBPL3 FARP1 PKD1L3 CTSH

5.70e-061308756434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP47 ALMS1 SPC25 SPOCK2 LRBA

1.34e-05155875441fcb6d05364fc6f4973f0b973f1a80b573ce1f
ToppCellNS-moderate-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFAP47 ALMS1 FANCI DTL CDC20B

1.42e-05157875410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DPP10 TNFSF10 SPON1 SPOCK2 PROC

2.03e-051698758f397cf4f9fd7c6fa88d01a95289ce2a6bc6938d
ToppCellNS-critical-d_0-4-Epithelial-FOXN4+|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DPP10 FANCI ATP13A5 SEMA5A CFI

2.21e-05172875a00bb44d33658cb3a98accd6b60f3ce964c425b4
ToppCell10x5'-bone_marrow-Lymphocytic_NK-Cycling_NK|bone_marrow / Manually curated celltypes from each tissue

FANCI DTL SPC25 SLC30A8 KIF14

2.27e-051738758a9dd85f718564c07cf3120ad648daeb60c94fc5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FANCI DTL SPC25 CDC20B KIF14

2.34e-0517487584da9faff088d05233183b425385beb054c92d1b
ToppCellHealthy/Control-Plasmablast|Healthy/Control / Disease group and Cell class

NLRP7 IGHA1 DTL SPC25 KIF14

2.34e-0517487597d19ef3240a1f648c6befaabb9ce45ad469cbce
ToppCell390C-Myeloid-Dendritic-pDC|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

NLRP7 CAPRIN2 ZDBF2 PTGDS PROC

2.47e-05176875aab9603b7943b7f7243eb6190ebba998566196f3
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG7 IFT172 CDC20B MUC5B FBXO15

2.47e-05176875dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCellControl|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DTL ISM1 SLCO1B3 SNRK RASAL2

2.53e-05177875b8ff6940e31b749776e81ae4f5bbd577dba9749c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH17 SNRK SPOCK2 PHYHIPL AKR1C2

2.53e-05177875da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCellHealthy_donor-Plasmablast|Healthy_donor / disease group, cell group and cell class (v2)

NLRP7 IGHA1 DTL SPC25 KIF14

2.60e-05178875388b8b4fa20dcc6e9ae4b06118e20b2c20c52bde
ToppCellsevere-multiplets|World / disease stage, cell group and cell class

SPTBN5 IGHA1 DTL SPC25 KIF14

2.90e-051828755e30ec7120a988d9ee3000513e1209618f28f5f9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FARP1 SPON1 SEMA5A SPOCK2 PHYHIPL

2.90e-051828755e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCelldroplet-Lung-nan-18m-Myeloid-Proliferating_Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FANCI DTL CAPRIN2 SPC25 MUC5B

2.90e-0518287511494a66d986297b837332ee9d382b71b9f22591
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DTL CAPRIN2 SPC25 KIF14 MUC5B

2.97e-051838756c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

OSBPL3 DTL KIF14 PRKDC LRBA

3.13e-05185875a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellMild-CD4+_T|Mild / Disease group and Cell class

PTPN13 SPON1 TNS2 SPOCK2 CTSH

3.13e-05185875c28ecb63146de1b02418e5a4fad0ae7c2b66a41d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TNFSF10 FARP1 SPON1 SPOCK2 PHYHIPL

3.21e-051868755c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FANCI DTL SPC25 KIF14 SPOCK2

3.21e-05186875993c58ef4445bf81bbc9b489635883848b5b4c8e
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

OSBPL3 DTL KIF14 PRKDC LRBA

3.21e-051868758571956890fc9894d766ba294a28e376b4aba428
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

PTPN13 OSBPL3 FARP1 SNRK LRBA

3.47e-05189875830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPON1 SPOCK2 PHYHIPL AKR1C2 PROC

3.56e-05190875b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTP1 SPON1 WNT16 SEMA5A PTGDS

3.56e-05190875050d6e0546954675b6adbfecb67854b1e09739d1
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FANCI DTL ISM1 SPC25 SEMA5A

3.56e-05190875e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

FANCI DTL SPC25 KIF14 TBCD

3.56e-05190875d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Cycling_T|GI_small-bowel / Manually curated celltypes from each tissue

FANCI DTL SPC25 KIF14 PHYHIPL

3.65e-05191875e642fa7395c05fb53324c9d46bbc52f89fc9673f
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TNFSF10 SPON1 SPOCK2 PHYHIPL PROC

3.83e-051938750f2167eef8203a5659c8c72e4e77646003d64797
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TNFSF10 DTL SLCO1B3 SNRK RASAL2

3.83e-05193875af5108260783e69a7d67896c5bf64f862525926d
ToppCellhuman_hepatoblastoma-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

FANCI DTL SPC25 KIF14 TBCD

3.83e-051938754b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCellPSB-critical-LOC-Epithelial-FOXN4+|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FANCI DTL ISM1 CDC20B KIF14

3.83e-05193875b7d9c5bed524423e92f01496a9f8fad11b33a3f7
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating-T_cells_proliferating_L.1.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FANCI DTL SPC25 KIF14 SPOCK2

3.83e-05193875b835d28de9daeec5213172c96f62b332cda53bb5
ToppCell3'_v3-Lung-Myeloid_Mac-Cycling_Myeloid-Mac|Lung / Manually curated celltypes from each tissue

FANCI DTL SPC25 KIF14 PIWIL3

3.93e-05194875a8ae49157ca3f9e8b3f1750a995aee012dc859b6
ToppCellwk_20-22-Hematologic_Lymphocytic-B-Pro-B|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SLC22A16 FANCI DTL SPC25 KIF14

3.93e-051948753590ff471f74a361ee5bf02a58e3104cd3bf7d00
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NLRP7 IGHA1 DTL SPC25 CTSH

3.93e-05194875ffba703f61faaac8b4b9a5e46cd335214303de7b
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TNFSF10 DTL SLCO1B3 SNRK RASAL2

3.93e-051948750b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FANCI DTL SPC25 KIF14 SPOCK2

4.02e-0519587567670d16ddd5d5ab7bc2254df329f5a7b2581556
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FANCI DTL SPC25 KIF14 SPOCK2

4.02e-0519587523dc2f8a3a038195a31feee7e3a51094a7a7c23e
ToppCellCOVID-19-T_cells-Cycling_NK/T_cells|COVID-19 / group, cell type (main and fine annotations)

SLC22A16 FANCI DTL SPC25 KIF14

4.02e-05195875764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PTPN13 FARP1 ATP2C2 LRBA BTBD9

4.02e-051958759406866f99555198a9be311fbd65751b70f35446
ToppCellCOVID-19_Convalescent-CD4+_Tcm|COVID-19_Convalescent / Disease condition and Cell class

SUPT3H PTPN13 TNFSF10 SPOCK2 CTSH

4.12e-05196875f2a5eeb1cebde2762865ab29792370b751214c4d
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating-T_cells_proliferating_L.1.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FANCI DTL SPC25 KIF14 SPOCK2

4.12e-051968759d4f0a95e49bda25864cbe27e4e86096cba5609f
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TNFSF10 PLEKHG7 ATP2C2 CDC20B AKR1C2

4.12e-05196875b07db4a53ab9be9aad6fae5e45f9547db829d096
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TNFSF10 PLEKHG7 ATP2C2 CDC20B AKR1C2

4.12e-05196875c366f980cc04abfe1c0c14746c11810c812a42c0
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FANCI DTL SPC25 KIF14 PTGDS

4.22e-0519787576b61e60a757e58b465569538e632d6d9953e89a
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DPP10 FANCI FARP1 KIF14 SEMA5A

4.22e-05197875196eaecef7003ed83f323c1f157c6a3594650097
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial|6_mon / Sample Type, Dataset, Time_group, and Cell type.

SPON1 SEMA5A CFI CTSH PHYHIPL

4.22e-05197875965d5a3f8c9b12cb8a8d3429702ae29ebd8c6122
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial-Astroglia|6_mon / Sample Type, Dataset, Time_group, and Cell type.

SPON1 SEMA5A CFI CTSH PHYHIPL

4.22e-051978753f088eb29197bc575400d6dafd8083e69e4a149f
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NLRP7 IGHA1 DTL SPC25 KIF14

4.22e-051978756fe013f98c64b3c5a4e61002254717fb411f8e59
ToppCellBrain_organoid-organoid_Velasco_nature-6_mon-Macroglial-Astroglia|6_mon / Sample Type, Dataset, Time_group, and Cell type.

SPON1 SEMA5A PTGDS CTSH PHYHIPL

4.33e-05198875715ecad21f572b195ff3b78216b1a7b32bbb4ace
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_ciliated-Deuterosomal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP47 AADACL2 DTL CDC20B KIF14

4.33e-05198875f31790442ef142f1c0c49bf3daf2d0efb193d2c9
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasmablast|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NLRP7 IGHA1 FANCI DTL SPC25

4.33e-05198875cfbe0bae21b6cd9cd15d3e659b618b44cfe3eaec
ToppCellBrain_organoid-organoid_Velasco_nature-6_mon-Macroglial|6_mon / Sample Type, Dataset, Time_group, and Cell type.

SPON1 SEMA5A PTGDS CTSH PHYHIPL

4.33e-051988759d03768f8b6c74e060c5f045508538f9b331f469
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

DCAF13 FANCI DTL SPC25 KIF14

4.33e-05198875880f9817f5145f10f29fc05c5866090433532fe2
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-IN_Progenitors|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

SPON1 SEMA5A PTGDS CTSH PHYHIPL

4.33e-051988753811d9e3e54bbe8b208c591697e43b55ab5bbf0e
ToppCellMS-cycling-|MS / Condition, Cell_class and T cell subcluster

IGHA1 FANCI DTL SPC25 KIF14

4.33e-0519887519c5d6b65de490118574b1f86b45c58b3a51df7f
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TNFSF10 SEMA5A CFI PHYHIPL PROC

4.33e-05198875be305d89d48c67ce922fa71aaf15e24d00c89ff6
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

FANCI DTL SPC25 KIF14 SPOCK2

4.33e-0519887580b105a7c7d00ea3b5e586831fbb755bd84f9d1a
ToppCellMS-cycling|MS / Condition, Cell_class and T cell subcluster

IGHA1 FANCI DTL SPC25 KIF14

4.33e-051988750c22f2cc0e5ca91cabcd4aac2b9ef05af47e967f
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FANCI DTL SPC25 KIF14 SPOCK2

4.33e-05198875c73e906d2d12d6eba0e606958be16e63a2292cd0
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2_proliferating-AT2_proliferating_L.0.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FANCI DTL SPC25 KIF14 CTSH

4.43e-05199875d7dbc551c05da32c698908348572fb0ce1166e10
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DPP10 ATP2C2 LRP1 SEMA5A PHYHIPL

4.43e-05199875333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PTPN13 FARP1 ATP2C2 BTBD9 CTSH

4.43e-051998755cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2_proliferating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FANCI DTL SPC25 KIF14 CTSH

4.43e-051998756a89c3a65fa50af92585c52bec203bcff6f94efc
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DPP10 ATP2C2 LRP1 SEMA5A PHYHIPL

4.43e-05199875e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SPTBN5 PTPN13 RAP2B BTBD9 CTSH

4.43e-05199875121de4e02585de3a3010398387c523bacf8ce546
ToppCellTCGA-Stomach-Primary_Tumor|TCGA-Stomach / Sample_Type by Project: Shred V9

DCAF13 OSBPL3 FANCI DTL KIF14

4.43e-0519987538f1f612b29feb868322999ceeda78e52447ec4f
ToppCellSepsis-Bac-SEP-Myeloid-pDC|Bac-SEP / Disease, condition lineage and cell class

NLRP7 IGHA1 PTGDS TTC3 PROC

4.43e-051998757f6569de050262f3d8d9d41c0f0cc139de85c0cb
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma|TCGA-Stomach / Sample_Type by Project: Shred V9

DCAF13 OSBPL3 FANCI DTL KIF14

4.43e-05199875b10698aee2e6c17bc559eb4f723024141f914b90
ToppCellBiopsy_Control_(H.)-Immune-Proliferating_Macrophages|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

FANCI DTL SPC25 KIF14 AKR1C2

4.54e-05200875ce9fad55f779afd3d6c5a9c5a15e2d9f548b7c7e
ToppCellcritical-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FANCI DTL ISM1 CDC20B SEMA5A

4.54e-05200875f39db4250ce220a3eb58edee3f7fc3671701d46f
ToppCellMacroglial-Astrocytes-GFAP---|Macroglial / cells hierarchy compared to all cells using T-Statistic

CFAP47 DPP10 SPON1 SPOCK2 CTSH

4.54e-0520087588d66550781a3c9102ff7455f5cff6fb072943cd
ToppCellMacroglial-Astrocytes-GFAP-|Macroglial / cells hierarchy compared to all cells using T-Statistic

CFAP47 DPP10 SPON1 SPOCK2 CTSH

4.54e-05200875d6a059b0ef763c281c60b1ac76da6079ea822f80
ToppCellMacroglial-Astrocytes-GFAP--|Macroglial / cells hierarchy compared to all cells using T-Statistic

CFAP47 DPP10 SPON1 SPOCK2 CTSH

4.54e-0520087516269fa4adb28fc6ed032bbdba8781237dd0d249
ToppCellMacroglial-Astrocytes-GFAP----L1-2|Macroglial / cells hierarchy compared to all cells using T-Statistic

CFAP47 DPP10 SPON1 SPOCK2 CTSH

4.54e-05200875c6f43bbbd5df5f2c19ae385f1a6b6a330abede2f
ToppCellBiopsy_IPF-Immune-Proliferating_T_cells|Biopsy_IPF / Sample group, Lineage and Cell type

FANCI DTL SPC25 KIF14 SPOCK2

4.54e-05200875c43d1a83b2a8ad060f3d80c9438da8b7a5e307fb
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte-|COVID_vent / Disease condition, Lineage, Cell class and subclass

FANCI DTL SPC25 KIF14 PRKDC

4.54e-052008757e4c0db43a03ca11380a54f44a3cf1991e055b80
ToppCellMacroglial-Astrocytes-GFAP|Macroglial / cells hierarchy compared to all cells using T-Statistic

CFAP47 DPP10 SPON1 SPOCK2 CTSH

4.54e-0520087579634b1086934412ae92f259ab43554ce545008f
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte|COVID_vent / Disease condition, Lineage, Cell class and subclass

FANCI DTL SPC25 KIF14 PRKDC

4.54e-052008759775ca7dedb76fcbb74f80f86b33c94e394c320a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FANCI DTL CDC20B KIF14

1.09e-041268748ae631694bbba40f64e55e2be8162d7a40eeadc5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH17 SNRK PHYHIPL AKR1C2

1.34e-04133874f303ab771482281d8793974f9f5279cee09431fe
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Nxph2_Sla|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SPTBN5 SPON1 DTL SEMA5A

1.38e-041348746d97fa07f55ae20c17b9d5262e893957cccc6dba
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN13 OSBPL3 ISM1 SEMA5A

1.73e-0414287458c2882cb0ede8cc5d84c85a650d28267268e748
Diseaselarge artery stroke

SUPT3H FARP1 DTL LRP1

3.40e-04113864EFO_0005524
DiseaseBardet-Biedl Syndrome

ALMS1 IFT172

6.41e-0413862C0752166
Diseasecolonic neoplasm, overall survival

DPP10 ISM1

7.47e-0414862EFO_0000638, EFO_0004288
Diseasediffuse idiopathic skeletal hyperostosis

SUPT3H SLC30A8

8.60e-0415862EFO_0007236
Diseaselysophosphatidylcholine 20:5 measurement

RAP2B DPP10

1.39e-0319862EFO_0010364
Diseaseblood metabolite measurement

ALMS1 SLC22A16

1.39e-0319862EFO_0005664
Diseasecolorectal cancer

DPP10 OSBPL3 CAPRIN2 LRP1 SPOCK2 LRBA BTBD9

1.94e-03604867MONDO_0005575
Diseasesquamous cell lung carcinoma, family history of lung cancer

BTBD9 IL1RL2 PROC

1.99e-0385863EFO_0000708, EFO_0006953
DiseaseBMI-adjusted fasting blood glucose measurement

SPC25 SLC30A8

2.04e-0323862EFO_0008036
Diseasefasting blood glucose measurement, HOMA-B, fasting blood insulin measurement

SPC25 SLC30A8

2.41e-0325862EFO_0004465, EFO_0004466, EFO_0004469
Diseasechromatid-type aberration frequency

DPP10 SEMA5A

2.61e-0326862EFO_0009862
Diseasepain

SUPT3H LRP1 SPOCK2 PKD1L3

2.62e-03196864EFO_0003843

Protein segments in the cluster

PeptideGeneStartEntry
CALMFSLDWIKAKTE

APAF1

501

O14727
FKAWMAEKDANSVTS

BZW2

191

Q9Y6E2
WKIMALDAIAKTCTF

AADACL2

31

Q6P093
TAWKMEDCIVDSCKF

ATP13A5

556

Q4VNC0
LVDQDKTMFICKSSW

CFI

131

P05156
KCKISEEMSNFLAWL

HTR1F

321

P30939
DLCSYMSWKTRKDTQ

ALMS1

341

Q8TCU4
TESQSFRKKCFKEWM

DTL

81

Q9NZJ0
AICEANIETWMKDKS

DENND6B

516

Q8NEG7
VKWTSDSKYIMCGSD

DCAF13

331

Q9NV06
CSKKYEMTSDTWLSQ

DPP10

356

Q8N608
SSEQKWMAVKCSLKT

ATP2C2

486

O75185
KDDCLLMVWSVTNKS

AP4E1

936

Q9UPM8
DGTTAASCKDMAKTW

MUC5B

5236

Q9HC84
ASCKDMAKTWLVPDS

MUC5B

5241

Q9HC84
VFTASCDKTAKMWDL

RAE1

101

P78406
CDKTAKMWDLSSNQA

RAE1

106

P78406
MFTKKEGQWDCSVCL

RANBP2

1661

P49792
EEWSCPFMETSAKNK

RAP2B

136

P61225
MLSWTSKICKENSRE

FANCI

1006

Q9NVI1
TFWSLEKFESKLAAM

KIF14

1136

Q15058
WADQVSEKMGTCSKA

LRP1

1801

Q07954
SCSMKLTIKEIWFSF

KIAA1109

1996

Q2LD37
FTMASRDACKAFWKT

FRMD7

256

Q6ZUT3
DKAWLLSMIQSKCSV

NXF1

131

Q9UBU9
KCFSCNSASERDKWM

RASAL2

136

Q9UJF2
CQAEVWSMFTAILKK

LRBA

106

P50851
SMLIASNETWKKVEC

LY75

1636

O60449
CKSSDWFIHTCMAAK

GPR151

111

Q8TDV0
AEKCWMKAAELSIKF

IFT172

1311

Q9UG01
SWVLTAAHCMDESKK

PROC

246

P04070
DFTEQSQCMKTKFWK

IL1RL2

516

Q9HB29
FDTVFWKCDMQKLTV

CABP7

116

Q86V35
DTCTKDAISAGKNWM

CHERP

166

Q8IWX8
MNDTRETCWKFFIEK

DNAH17

2906

Q9UFH2
MASRDFCKSFWKICV

FARP1

296

Q9Y4F1
WKTDIFDGCIKSCSM

FBXO15

411

Q8NCQ5
RTWKCAFMETSAKLN

DIRAS2

141

Q96HU8
AAEDWKKGDTFSCMV

IGHA1

301

P01876
CVNSLEKFHFKSWMS

CTSH

26

P09668
TKSWTTPMCEEQDSK

CAPRIN2

526

Q6IMN6
KFTLCWTEFVDMKVH

FKTN

396

O75072
KVITQSTAVKAMDWC

CDC20B

396

Q86Y33
MVADRTKVSCKSWQS

BTBD9

511

Q96Q07
LKAALDVWCKNESSM

PIWIL3

701

Q7Z3Z3
KKCSIVIEMSKFEAW

CFAP47

1681

Q6ZTR5
SCERWMSCKSEFLKK

ISM1

296

B1AKI9
EKMCLWSTDAISKDV

CDC37L1

121

Q7L3B6
LWLQSSEDMEKCSKD

OSBPL3

211

Q9H4L5
KKIWASSMDLLCTAD

PTPN13

296

Q12923
TFHCSWKMPKSEVAS

OSBPL11

456

Q9BXB4
ITCDSFKISWEMDSK

PHYHIPL

61

Q96FC7
TMCKSVTTDEWKKVF

RTP1

36

P59025
WSACSSSTCDKGKRM

SPON1

451

Q9HCB6
CSSIDKLDKMAWKDV

HARS2

236

P49590
MAKWNRASSCKLSEL

SLC22A16

311

Q86VW1
KLCADFKRTGMDSNW

TAF1L

866

Q8IZX4
FSNKCSERWKTMSAK

HMGB1P1

41

B2RPK0
NSSWLREKKAALSMC

PTGDS

51

P41222
ESFTSLQMSKKGCVW

PKD1L3

1451

Q7Z443
TLAKKCMLDWTDCNL

NLRP7

186

Q8WX94
EKSTWKMCISSTGNA

SNRK

681

Q9NRH2
FLSSVEKMERWLCSK

SPTBN5

2581

Q9NRC6
KKCTSLEESLSMTQW

SEMA5A

511

Q13591
FWNKFKSTDTSCQMA

SPC25

16

Q9HBM1
TVDLCATWEAMEKCK

AKR1C2

141

P52895
TFFKMVSMRDCKSWL

ULBP3

181

Q9BZM4
ADESKWLCSEFKESM

TDP1

406

Q9NUW8
KWKLCSASAICFIFM

SLC30A8

71

Q8IWU4
KASKFRDWLDCSSME

SUPT3H

196

O75486
WNMKTTECSNTFKSL

SMU1

376

Q2TAY7
KVEKCISDAMSWLNS

HSPA4L

736

O95757
WSTMEVCVDCKKFIS

SPIRE1

696

Q08AE8
ELDIMKFICKDFWTT

TRAPPC6B

61

Q86SZ2
FGALIDKTCMKWSTN

SLCO1B3

591

Q9NPD5
TAFWEQKCSVSSEMK

ZDBF2

351

Q9HCK1
EFHMNCWKKLKTTTF

TTC3

686

P53804
SAKDALLLWCQMKTA

SPTBN4

181

Q9H254
AVKTCWKTMSSFEKI

WNT16

231

Q9UBV4
KECSPWMSDFKVEFL

PRKDC

3681

P78527
CFFSWSLKKMELEFS

XNDC1N

181

Q6ZNB5
AVASTKMSCKCNSWE

ZNF510

166

Q9Y2H8
KKTWMAQITTAISCF

PLEKHG7

656

Q6ZR37
KQSKMAEFLDWSLCN

TBCD

221

Q9BTW9
LLMKSARNSCWSKDA

TNFSF10

221

P50591
LCGSKADTWDAKTLM

TRIP12

1866

Q14669
WKTTMKSSVQEECVS

TRMT10C

66

Q7L0Y3
DKLCSICKAMETWLS

TNS2

206

Q63HR2
WYKMDDAKVTACSIT

USP17L2

346

Q6R6M4
CKDSIGWMFSKLDTS

SPOCK2

246

Q92563
TFMVSCLKETVWMKF

GEMIN4

601

P57678