Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCA2 ATP7B ABCC5 ABCA8 ATP6V0A2	1.21e-04	109	88	5	GO:0042626
GeneOntologyBiologicalProcess	inner ear receptor cell stereocilium organization	TPRN STRC STRCP1 OTOG	7.72e-05	53	88	4	GO:0060122
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	SHANK1 DIP2B MAP2 TPRN PLXNA4 BBS1 NFASC AFDN STRC RET RAPGEF2 STRCP1	7.78e-05	748	88	12	GO:0048667
GeneOntologyBiologicalProcess	positive regulation of B cell mediated immunity	ATAD5 IGHG3 IGHG4 TP53BP1	9.59e-05	56	88	4	GO:0002714
GeneOntologyBiologicalProcess	positive regulation of immunoglobulin mediated immune response	ATAD5 IGHG3 IGHG4 TP53BP1	9.59e-05	56	88	4	GO:0002891
GeneOntologyBiologicalProcess	positive regulation of female receptivity	NCOA2 NCOA1	1.07e-04	4	88	2	GO:0045925
GeneOntologyBiologicalProcess	cellular response to Thyroglobulin triiodothyronine	NCOA2 NCOA1	1.07e-04	4	88	2	GO:1904017
GeneOntologyBiologicalProcess	cell morphogenesis	SHANK1 DIP2B FAT1 MAP2 MYO9A TPRN PLXNA4 BBS1 NFASC AFDN STRC RET RAPGEF2 ZMYM3 STRCP1	1.48e-04	1194	88	15	GO:0000902
GeneOntologyBiologicalProcess	auditory receptor cell stereocilium organization	TPRN STRC STRCP1	1.82e-04	26	88	3	GO:0060088
GeneOntologyBiologicalProcess	myelin assembly	ABCA2 ANK2 NFASC	2.28e-04	28	88	3	GO:0032288
GeneOntologyBiologicalProcess	response to Thyroglobulin triiodothyronine	NCOA2 NCOA1	2.67e-04	6	88	2	GO:1904016
GeneOntologyBiologicalProcess	inner ear receptor cell development	TPRN STRC STRCP1 OTOG	2.69e-04	73	88	4	GO:0060119
GeneOntologyBiologicalProcess	chemosensory behavior	SHANK1 BBS1 MRGPRX3	3.09e-04	31	88	3	GO:0007635
GeneOntologyBiologicalProcess	auditory receptor cell morphogenesis	TPRN STRC STRCP1	3.09e-04	31	88	3	GO:0002093
GeneOntologyBiologicalProcess	neuron projection development	SHANK1 DIP2B MAP2 MYO9A TPRN PLXNA4 BBS1 NFASC AFDN CRTAC1 STRC RET RAPGEF2 STRCP1 OTOG	3.28e-04	1285	88	15	GO:0031175
GeneOntologyBiologicalProcess	regulation of B cell mediated immunity	ATAD5 IGHG3 IGHG4 TP53BP1	3.64e-04	79	88	4	GO:0002712
GeneOntologyBiologicalProcess	regulation of immunoglobulin mediated immune response	ATAD5 IGHG3 IGHG4 TP53BP1	3.64e-04	79	88	4	GO:0002889
Domain	DUF1518	NCOA2 NCOA1	5.98e-05	3	84	2	PF07469
Domain	DUF1518	NCOA2 NCOA1	5.98e-05	3	84	2	IPR010011
Domain	Nuc_rcpt_coact_Ncoa-typ	NCOA2 NCOA1	5.98e-05	3	84	2	IPR014920
Domain	SRC-1	NCOA2 NCOA1	5.98e-05	3	84	2	IPR014935
Domain	Src1_rcpt_coact	NCOA2 NCOA1	5.98e-05	3	84	2	IPR008955
Domain	Nuclear_rcpt_coactivator	NCOA2 NCOA1	5.98e-05	3	84	2	IPR017426
Domain	DUF1518	NCOA2 NCOA1	5.98e-05	3	84	2	SM01151
Domain	SRC-1	NCOA2 NCOA1	5.98e-05	3	84	2	PF08832
Domain	-	NCOA2 NCOA1	5.98e-05	3	84	2	4.10.630.10
Domain	Nuc_rec_co-act	NCOA2 NCOA1	5.98e-05	3	84	2	PF08815
Domain	Nuc_rcpt_coact	NCOA2 NCOA1	2.96e-04	6	84	2	IPR009110
Domain	RA	MYO9A AFDN RAPGEF2	3.60e-04	31	84	3	SM00314
Domain	PDZ	SHANK1 MPP4 AFDN RAPGEF2 AHNAK2	4.37e-04	141	84	5	PF00595
Domain	AAA+_ATPase	ABCA2 ATAD5 ABCC5 DNAH6 ABCA8	4.81e-04	144	84	5	IPR003593
Domain	AAA	ABCA2 ATAD5 ABCC5 DNAH6 ABCA8	4.81e-04	144	84	5	SM00382
Domain	PDZ	SHANK1 MPP4 AFDN RAPGEF2 AHNAK2	5.45e-04	148	84	5	SM00228
Domain	RA	MYO9A AFDN RAPGEF2	5.63e-04	36	84	3	PF00788
Domain	-	SHANK1 MPP4 AFDN RAPGEF2 AHNAK2	5.79e-04	150	84	5	2.30.42.10
Domain	PDZ	SHANK1 MPP4 AFDN RAPGEF2 AHNAK2	5.97e-04	151	84	5	PS50106
Domain	RA	MYO9A AFDN RAPGEF2	6.11e-04	37	84	3	PS50200
Domain	PDZ	SHANK1 MPP4 AFDN RAPGEF2 AHNAK2	6.15e-04	152	84	5	IPR001478
Domain	RA_dom	MYO9A AFDN RAPGEF2	7.69e-04	40	84	3	IPR000159
Domain	ABC_A	ABCA2 ABCA8	1.28e-03	12	84	2	IPR026082
Domain	ABC_tran	ABCA2 ABCC5 ABCA8	1.31e-03	48	84	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA2 ABCC5 ABCA8	1.31e-03	48	84	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCA2 ABCC5 ABCA8	1.39e-03	49	84	3	PS00211
Domain	ABC_transporter-like	ABCA2 ABCC5 ABCA8	1.48e-03	50	84	3	IPR003439
Domain	ConA-like_dom	FAT1 COL14A1 NBEA TRIM22 ADGRG4	3.09e-03	219	84	5	IPR013320
Domain	PAS	NCOA2 NCOA1	5.61e-03	25	84	2	PF00989
Domain	PAS_fold	NCOA2 NCOA1	5.61e-03	25	84	2	IPR013767
Pubmed	Dhx33 promotes B-cell growth and proliferation by controlling activation-induced rRNA upregulation.	CD19 IGHG3 IGHG4 DHX33	2.91e-09	8	90	4	36631557
Pubmed	Id3 Orchestrates Germinal Center B Cell Development.	CD19 IGHG3 IGHG4	3.33e-07	6	90	3	27457619
Pubmed	Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice.	CD19 IGHG3 IGHG4	3.33e-07	6	90	3	21339646
Pubmed	The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma.	CD19 IGHG3 IGHG4	3.33e-07	6	90	3	28069569
Pubmed	O-GlcNAcylation is required for B cell homeostasis and antibody responses.	CD19 IGHG3 IGHG4	3.33e-07	6	90	3	29187734
Pubmed	Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.	CD19 IGHG3 IGHG4	3.33e-07	6	90	3	26366712
Pubmed	STAT3 signaling in B cells controls germinal center zone organization and recycling.	CD19 IGHG3 IGHG4	3.33e-07	6	90	3	37200190
Pubmed	ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis.	CD19 IGHG3 IGHG4	5.82e-07	7	90	3	38458187
Pubmed	Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.	CD19 IGHG3 IGHG4	5.82e-07	7	90	3	18835195
Pubmed	Autonomous membrane IgE signaling prevents IgE-memory formation.	CD19 IGHG3 IGHG4	5.82e-07	7	90	3	27428827
Pubmed	B-Cell-Specific Myd88 L252P Expression Causes a Premalignant Gammopathy Resembling IgM MGUS.	CD19 IGHG3 IGHG4	5.82e-07	7	90	3	33343574
Pubmed	Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits.	CD19 IGHG3 IGHG4	5.82e-07	7	90	3	25180063
Pubmed	Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis.	CD19 IGHG3 IGHG4	5.82e-07	7	90	3	30538335
Pubmed	TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.	CD19 IGHG3 IGHG4	5.82e-07	7	90	3	30274972
Pubmed	The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment.	NCOA2 NCOA1 NR4A1	9.30e-07	8	90	3	12082103
Pubmed	Mouse model for acute Epstein-Barr virus infection.	CD19 IGHG3 IGHG4	9.30e-07	8	90	3	27856754
Pubmed	Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells.	CD19 IGHG3 IGHG4	9.30e-07	8	90	3	22431510
Pubmed	Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.	CD19 IGHG3 IGHG4	9.30e-07	8	90	3	33432228
Pubmed	Transcription factors of the alternative NF-κB pathway are required for germinal center B-cell development.	CD19 IGHG3 IGHG4	9.30e-07	8	90	3	27457956
Pubmed	TRAF3 Acts as a Checkpoint of B Cell Receptor Signaling to Control Antibody Class Switch Recombination and Anergy.	CD19 IGHG3 IGHG4	9.30e-07	8	90	3	32591397
Pubmed	The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response.	CD19 IGHG3 IGHG4	1.39e-06	9	90	3	31767615
Pubmed	Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.	CD19 IGHG3 IGHG4	1.39e-06	9	90	3	32522871
Pubmed	TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate.	CD19 IGHG3 IGHG4	1.39e-06	9	90	3	32619424
Pubmed	The X-Linked Helicase DDX3X Is Required for Lymphoid Differentiation and MYC-Driven Lymphomagenesis.	CD19 IGHG3 IGHG4	1.39e-06	9	90	3	35815807
Pubmed	Regulation of B cell fate by chronic activity of the IgE B cell receptor.	CD19 IGHG3 IGHG4	1.39e-06	9	90	3	27935477
Pubmed	Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells.	CD19 IGHG3 IGHG4	1.98e-06	10	90	3	33207194
Pubmed	PRMT5 is essential for B cell development and germinal center dynamics.	CD19 IGHG3 IGHG4	1.98e-06	10	90	3	30604754
Pubmed	BTG1 mutation yields supercompetitive B cells primed for malignant transformation.	CD19 IGHG3 IGHG4	2.72e-06	11	90	3	36656933
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1 OTOG	2.72e-06	11	90	3	31776257
Pubmed	T-bet regulates T-independent IgG2a class switching.	CD19 IGHG3 IGHG4	2.72e-06	11	90	3	12882831
Pubmed	IgH isotype-specific B cell receptor expression influences B cell fate.	CD19 IGHG3 IGHG4	3.62e-06	12	90	3	28923960
Pubmed	Inflammation-induced formation of fat-associated lymphoid clusters.	CD19 IGHG3 IGHG4	5.97e-06	14	90	3	26147686
Pubmed	SRC-1 and TIF2 control energy balance between white and brown adipose tissues.	NCOA2 NCOA1	6.62e-06	2	90	2	12507421
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	6.62e-06	2	90	2	11687802
Pubmed	B cell-specific deficiency for Smad2 in vivo leads to defects in TGF-beta-directed IgA switching and changes in B cell fate.	CD19 SMAD2	6.62e-06	2	90	2	16455997
Pubmed	Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction.	NCOA2 NCOA1	6.62e-06	2	90	2	15070739
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	6.62e-06	2	90	2	34910522
Pubmed	Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency.	NCOA2 NCOA1	6.62e-06	2	90	2	11897715
Pubmed	Tumor necrosis factor-alpha suppresses the expression of steroid receptor coactivator-1 and -2: a possible mechanism contributing to changes in steroid hormone responsiveness.	NCOA2 NCOA1	6.62e-06	2	90	2	15231721
Pubmed	Distinct steady-state nuclear receptor coregulator complexes exist in vivo.	NCOA2 NCOA1	6.62e-06	2	90	2	9751728
Pubmed	Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis.	NCOA2 NCOA1	6.62e-06	2	90	2	25148457
Pubmed	Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action.	NCOA2 MAP2 NCOA1	9.16e-06	16	90	3	10882104
Pubmed	Dynamic regulation of B cell complement signaling is integral to germinal center responses.	CD19 IGHG3 IGHG4	9.16e-06	16	90	3	34031614
Pubmed	A comprehensive resource of interacting protein regions for refining human transcription factor networks.	NCOA2 ANK2 MAP2 NR4A1 TP53BP1 SMAD2	1.08e-05	191	90	6	20195357
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1 OTOG	1.11e-05	17	90	3	20856818
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DIP2B MAP2 MYO9A KDM3B AFDN AKAP13 LIMCH1 RAPGEF2 E2F8 OTOG AHNAK2	1.41e-05	861	90	11	36931259
Pubmed	Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.	IGHG3 IGHG4 SERPINA10 KNG1	1.71e-05	59	90	4	17330941
Pubmed	T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.	NCOA2 NCOA1 NR4A1	1.85e-05	20	90	3	11877444
Pubmed	The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.	NCOA2 NCOA1	1.98e-05	3	90	2	21035760
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	1.98e-05	3	90	2	30801007
Pubmed	Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors.	NCOA2 NCOA1	1.98e-05	3	90	2	24550004
Pubmed	Distinctive functions of p160 steroid receptor coactivators in proliferation of an estrogen-independent, tamoxifen-resistant breast cancer cell line.	NCOA2 NCOA1	1.98e-05	3	90	2	21059860
Pubmed	RORgammat recruits steroid receptor coactivators to ensure thymocyte survival.	NCOA2 NCOA1	1.98e-05	3	90	2	16148126
Pubmed	Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse.	NCOA2 NCOA1	1.98e-05	3	90	2	16914740
Pubmed	Absence of the steroid receptor coactivator-3 induces B-cell lymphoma.	NCOA2 NCOA1	1.98e-05	3	90	2	16675958
Pubmed	Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene.	NCOA2 NCOA1	1.98e-05	3	90	2	9506940
Pubmed	Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers.	NCOA2 NCOA1	1.98e-05	3	90	2	28390937
Pubmed	The role of SRC1 and SRC2 in steroid-induced SDF1 expression in normal and ectopic endometrium.	NCOA2 NCOA1	1.98e-05	3	90	2	24586072
Pubmed	Steroid receptor coactivator 2 is essential for progesterone-dependent uterine function and mammary morphogenesis: insights from the mouse--implications for the human.	NCOA2 NCOA1	1.98e-05	3	90	2	17045797
Pubmed	Research resource: loss of the steroid receptor coactivators confers neurobehavioral consequences.	NCOA2 NCOA1	1.98e-05	3	90	2	23927929
Pubmed	RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis.	CD19 RAPGEF2	1.98e-05	3	90	2	20595512
Pubmed	Effects of RET, NRG1 and NRG3 Polymorphisms in a Chinese Population with Hirschsprung Disease.	RET NRG3	1.98e-05	3	90	2	28256518
Pubmed	Recurrent MEIS1-NCOA2/1 fusions in a subset of low-grade spindle cell sarcomas frequently involving the genitourinary and gynecologic tracts.	NCOA2 NCOA1	1.98e-05	3	90	2	33574497
Pubmed	Expression and significance of androgen receptor coactivators in urothelial carcinoma of the bladder.	NCOA2 NCOA1	1.98e-05	3	90	2	18845648
Pubmed	The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP.	NCOA2 NCOA1	1.98e-05	3	90	2	12138202
Pubmed	Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain.	NCOA2 NCOA1	1.98e-05	3	90	2	14757047
Pubmed	Structure and chromosomal locations of mouse steroid receptor coactivator gene family.	NCOA2 NCOA1	1.98e-05	3	90	2	10501088
Pubmed	Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators.	NCOA2 NCOA1	1.98e-05	3	90	2	12114525
Pubmed	Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice.	NCOA2 NCOA1	1.98e-05	3	90	2	15983373
Pubmed	The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism.	NCOA2 NCOA1	1.98e-05	3	90	2	16423883
Pubmed	Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.	NCOA2 GRAMD2A MYO9A AFDN	2.52e-05	65	90	4	23319000
Pubmed	Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains.	IGHG3 IGHG4	3.96e-05	4	90	2	6283537
Pubmed	miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation.	NCOA2 NCOA1	3.96e-05	4	90	2	26066330
Pubmed	Somatic mutation in genes for the variable portion of the immunoglobulin heavy chain.	IGHG3 IGHG4	3.96e-05	4	90	2	6801765
Pubmed	Sequence analysis of cloned cDNA encoding part of an immunoglobulin heavy chain.	IGHG3 IGHG4	3.96e-05	4	90	2	113776
Pubmed	BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites.	CD19 TP53BP1	3.96e-05	4	90	2	28912125
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	3.96e-05	4	90	2	18849963
Pubmed	Highly specific anti-estradiol antibodies: structural characterisation and binding diversity.	IGHG3 IGHG4	3.96e-05	4	90	2	11812141
Pubmed	Multiple amino acid substitutions between murine gamma 2a heavy chain Fc regions of Ig1a and Ig1b allotypic forms.	IGHG3 IGHG4	3.96e-05	4	90	2	6794027
Pubmed	Immunoglobulin diversity: analysis of the germ-line VH gene repertoire of the murine anti-GAT response.	IGHG3 IGHG4	3.96e-05	4	90	2	6306571
Pubmed	Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation.	NCOA2 NCOA1	3.96e-05	4	90	2	11818499
Pubmed	Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins.	NCOA2 NCOA1	3.96e-05	4	90	2	10454563
Pubmed	Further evidence that BALB/c and C57BL/6 gamma 2a genes originate from two distinct isotypes.	IGHG3 IGHG4	3.96e-05	4	90	2	2510996
Pubmed	Spontaneous deletions in Ig heavy chain genes: flanking sequences influence splice site selection.	IGHG3 IGHG4	3.96e-05	4	90	2	1754385
Pubmed	Sialic acid residues are essential for the anaphylactic activity of murine IgG1 antibodies.	IGHG3 IGHG4	3.96e-05	4	90	2	19050247
Pubmed	The molecular and biochemical characterization of mutant monoclonal antibodies with increased antigen binding.	IGHG3 IGHG4	3.96e-05	4	90	2	1672339
Pubmed	An autoimmune disease variant of IgG1 modulates B cell activation and differentiation.	IGHG3 IGHG4	3.96e-05	4	90	2	30287618
Pubmed	Switch transcripts in immunoglobulin class switching.	IGHG3 IGHG4	3.96e-05	4	90	2	7892607
Pubmed	Determination of the primary structure of a mouse G2a immunoglobulin. Identification of the disulfide bridges.	IGHG3 IGHG4	3.96e-05	4	90	2	4565406
Pubmed	Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment.	IGHG3 IGHG4	3.96e-05	4	90	2	1713710
Pubmed	Structure of the constant and 3' untranslated regions of the murine Balb/c gamma 2a heavy chain messenger RNA.	IGHG3 IGHG4	3.96e-05	4	90	2	6777755
Pubmed	P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain.	NCOA2 NCOA1	3.96e-05	4	90	2	18267973
Pubmed	The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses.	IGHG3 IGHG4	3.96e-05	4	90	2	9103199
Pubmed	Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cells.	NCOA2 NCOA1	3.96e-05	4	90	2	15331759
Pubmed	Gene conversion and polymorphism: generation of mouse immunoglobulin gamma 2a chain alleles by differential gene conversion by gamma 2b chain gene.	IGHG3 IGHG4	3.96e-05	4	90	2	6297797
Pubmed	Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain.	IGHG3 IGHG4	3.96e-05	4	90	2	98524
Pubmed	IgG1 protects against renal disease in a mouse model of cryoglobulinaemia.	IGHG3 IGHG4	3.96e-05	4	90	2	25363774
Pubmed	Mutational deglycosylation of the Fc portion of immunoglobulin G causes O-sulfation of tyrosine adjacently preceding the originally glycosylated site.	IGHG3 IGHG4	3.96e-05	4	90	2	20621099
Pubmed	Immunoglobulin heavy constant gamma 1 silencing decreases tonicity-responsive enhancer-binding protein expression to alleviate diabetic nephropathy.	IGHG3 IGHG4	3.96e-05	4	90	2	38268239
Pubmed	Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98).	IGHG3 IGHG4	3.96e-05	4	90	2	12414967
Cytoband	3q27	LIPH ABCC5 KNG1	1.68e-05	25	91	3	3q27
Cytoband	Ensembl 112 genes in cytogenetic band chrXq13	FAM236D FAM236A FAM236B FAM236C ZMYM3	2.04e-05	165	91	5	chrXq13
Cytoband	Ensembl 112 genes in cytogenetic band chr1q24	METTL13 POGK FAM78B ALDH9A1	1.32e-04	129	91	4	chr1q24
Cytoband	11p15.1	MRGPRX3 E2F8 OTOG	2.38e-04	60	91	3	11p15.1
Cytoband	1q24.1	POGK FAM78B	1.04e-03	24	91	2	1q24.1
Cytoband	14q32.33	INF2 IGHG3 IGHG4 AHNAK2	1.13e-03	228	91	4	14q32.33
Cytoband	15q15.3	STRC STRCP1	1.13e-03	25	91	2	15q15.3
Cytoband	Ensembl 112 genes in cytogenetic band chr3q27	LIPH ABCC5 KNG1	2.15e-03	128	91	3	chr3q27
Cytoband	Xq13.2	FAM236A FAM236B	3.03e-03	41	91	2	Xq13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	STRC TP53BP1 STRCP1	3.18e-03	147	91	3	chr15q15
Cytoband	Ensembl 112 genes in cytogenetic band chr14q32	INF2 IGHG3 IGHG4 SERPINA10 AHNAK2	5.46e-03	566	91	5	chr14q32
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	MAP2 AKAP13 NBEA	1.52e-04	29	65	3	396
GeneFamily	PDZ domain containing	SHANK1 MPP4 AFDN RAPGEF2 AHNAK2	2.16e-04	152	65	5	1220
GeneFamily	Adhesion G protein-coupled receptors, subfamily G	ADGRG5 ADGRG4	2.64e-04	7	65	2	917
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	CD19 AKAP13 TRIM22	8.17e-04	51	65	3	870
GeneFamily	ATP binding cassette subfamily A	ABCA2 ABCA8	1.13e-03	14	65	2	805
GeneFamily	Cadherin related	FAT1 RET	1.67e-03	17	65	2	24
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	NCOA2 NCOA1	1.67e-03	17	65	2	486
ToppCell	LPS-IL1RA+antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO9A COL14A1 AKAP13 ZNF385B LIMCH1 ABCA8 GULP1	7.35e-08	177	90	7	b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANK2 MAP2 FAM78B NFASC NBEA RET ABCA8	1.69e-07	200	90	7	553e9612874480f4d2a45671462e266cd0a09321
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D122\|Adult / Lineage, Cell type, age group and donor	FAT1 LIPH AKAP13 ZNF385B LIMCH1 ST3GAL3	8.02e-07	157	90	6	31d1bd9138c60e8485664ec4144f987226e3eef9
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Adult / Lineage, Cell type, age group and donor	FAT1 LIPH AKAP13 ZNF385B LIMCH1 HID1	9.98e-07	163	90	6	e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCell	367C-Lymphocytic-Plasma_cell-\|367C / Donor, Lineage, Cell class and subclass (all cells)	ADGRG5 SPAG4 PLPP5 IGHG3 IGHG4 HID1	1.15e-06	167	90	6	f2185eb72f0137136f6d71af2a70168fded6c940
ToppCell	367C-Lymphocytic-Plasma_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	ADGRG5 SPAG4 PLPP5 IGHG3 IGHG4 HID1	1.15e-06	167	90	6	5e768cf24699893e05d1bcb1c92dba2336943a64
ToppCell	Int-URO-Lymphocyte-B-B_intermediate\|Int-URO / Disease, Lineage and Cell Type	ANK2 CD19 IGHG3 IGHG4 FAM78B NEB	1.19e-06	168	90	6	5b3fb1fc8fea810c6d4e6feb42c24fb57e8066de
ToppCell	metastatic_Brain-B_lymphocytes-Plasma_cells\|metastatic_Brain / Location, Cell class and cell subclass	ADGRG5 SPAG4 PLPP5 CD19 IGHG3 IGHG4	1.28e-06	170	90	6	53634da9e9c72f6400639954c286c6e38ea5a188
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADGRG5 ANK2 CD19 IGHG3 IGHG4 MRGPRX3	1.32e-06	171	90	6	a2938e56cb5749004317798dc7ac0f0c2d4d8ae0
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT1 LIPH PLXNA4 ABCC5 CRTAC1 NBEA	1.78e-06	180	90	6	b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	MAP2 LIPH AFDN LIMCH1 NRG3 ABCA8	2.02e-06	184	90	6	561592edc3083fad41b91811151b442207c65dd9
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GRAMD2A MAP2 LIPH AFDN LIMCH1 NRG3	2.08e-06	185	90	6	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-Plasma_B-Plasma_B-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADGRG5 SPAG4 PLPP5 CD19 IGHG3 IGHG4	2.08e-06	185	90	6	96423bdcf0e85ca41370f79347d27c22f3de98f5
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	MAP2 AFDN LIMCH1 NRG3 PAPSS2 ABCA8	2.22e-06	187	90	6	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	Control-Epithelial-ATI\|Epithelial / Disease state, Lineage and Cell class	MAP2 INF2 LIMCH1 NRG3 PAPSS2 ABCA8	2.22e-06	187	90	6	3a032432f780525f4f4c2a358897d9989b1ecae7
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-B_lymphocytic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPAG4 PLPP5 CD19 IGHG3 IGHG4 HID1	2.29e-06	188	90	6	c3cae529fdbeb233d2b32bcc3537a8aba26a7dc2
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANK2 PLXNA4 COL14A1 LIMCH1 ABCA8 GULP1	2.36e-06	189	90	6	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	Adult-Epithelial-club_cell\|Adult / Lineage, Cell type, age group and donor	FAT1 LIPH PLXNA4 ABCC5 NBEA GULP1	2.43e-06	190	90	6	756bff697d30aec56c0ebfca94295f084a15bf37
ToppCell	B_cells\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ADGRG5 SPAG4 CD19 IGHG3 IGHG4 HID1	2.51e-06	191	90	6	72e3191990973440e4f91427208df360f73e4f41
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANK2 PLXNA4 COL14A1 LIMCH1 ABCA8 GULP1	2.58e-06	192	90	6	dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANK2 PLXNA4 COL14A1 LIMCH1 ABCA8 GULP1	2.66e-06	193	90	6	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANK2 PLXNA4 COL14A1 LIMCH1 ABCA8 GULP1	2.74e-06	194	90	6	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANK2 PLXNA4 COL14A1 LIMCH1 ABCA8 GULP1	2.74e-06	194	90	6	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	MS-plasma-\|MS / Condition, Cell_class and T cell subcluster	SPAG4 PLPP5 CD19 IGHG3 IGHG4 HID1	2.82e-06	195	90	6	b0a51dea06899e6a4477c3436c85e114cd8f6214
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANK2 FAM78B PLXNA4 NFASC RET ABCA8	2.82e-06	195	90	6	9fea1ddb68da83ca43dd8006c9e51295b1817f0e
ToppCell	MS-plasma\|MS / Condition, Cell_class and T cell subcluster	SPAG4 PLPP5 CD19 IGHG3 IGHG4 HID1	2.82e-06	195	90	6	de866c0eaec36d94a3101eb9f949ca9544207f33
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT1 FCAR LIPH ABCC5 ZNF385B LIMCH1	2.91e-06	196	90	6	ed76eeb37400ca154feae9b7ebaddb6c434f8b81
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	NCOA2 MYO9A NCOA1 ZNF385B LIMCH1 RAPGEF2	2.91e-06	196	90	6	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANK2 MAP2 FAM78B NFASC RET ABCA8	2.91e-06	196	90	6	e874aa82a20bb59582c8cd7f8d30b2ed02903a85
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	NCOA2 MYO9A NCOA1 ZNF385B LIMCH1 RAPGEF2	3.08e-06	198	90	6	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	ASK428-Epithelial-Type_1\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	MAP2 INF2 LIPH LIMCH1 PAPSS2 ABCA8	3.08e-06	198	90	6	0047a9ef7684230ac5179efea94461480e90bdaf
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ANK2 PLXNA4 COL14A1 LIMCH1 PAPSS2 ABCA8	3.17e-06	199	90	6	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	NCOA2 DIP2B NCOA1 NBEA LIMCH1 RAPGEF2	3.17e-06	199	90	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYO9A LIPH CRTAC1 AKAP13 ZNF385B LIMCH1	3.17e-06	199	90	6	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ANK2 PLXNA4 COL14A1 LIMCH1 PAPSS2 ABCA8	3.27e-06	200	90	6	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	ANK2 PLXNA4 COL14A1 LIMCH1 PAPSS2 ABCA8	3.27e-06	200	90	6	a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCell	Adult-Immune-B_cell-D122\|Adult / Lineage, Cell type, age group and donor	SPAG4 PLPP5 CD19 IGHG3 IGHG4	1.58e-05	155	90	5	5857aebd43b901fc9f8c46f2d628582969db9e6a
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ANK2 CD19 IGHG3 IGHG4 NEB	1.63e-05	156	90	5	d81e78bec5c8a3f3ec9e1447ebab2c5805b815eb
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|368C / Donor, Lineage, Cell class and subclass (all cells)	ATAD5 ABCC5 LIMCH1 KLHDC4 GULP1	2.33e-05	168	90	5	1bc6a1915d48f547385ed4f44e118bcc8a4a7b6c
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	ATAD5 ABCC5 LIMCH1 KLHDC4 GULP1	2.33e-05	168	90	5	69f534de0f9a293047bea03cb1b78551087a8df5
ToppCell	BAL-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPAG4 CD19 IGHG3 IGHG4 HID1	2.39e-05	169	90	5	9ab34f602d46ce87283d243b81621e8806504f43
ToppCell	BAL-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPAG4 CD19 IGHG3 IGHG4 HID1	2.39e-05	169	90	5	89fbafdb4628ce7a90c50398870e0f8ee90cfd91
ToppCell	BAL-Control-Lymphocyte-B-Plasmablast-Plasmablast-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SPAG4 CD19 IGHG3 IGHG4 HID1	2.39e-05	169	90	5	75d367eb35768d3063096e8866cea649dac3b1bd
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-Plasma_cells\|B_lymphocytes / Location, Cell class and cell subclass	ADGRG5 SPAG4 IGHG3 IGHG4 RET	2.39e-05	169	90	5	150c08c7b1dc0f46173a7b8f6a3fc70d82906c0d
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAP2 MYO9A AFDN LIMCH1 ABCA8	2.39e-05	169	90	5	cd16e8462ee09877be962fbd9a3badcb825820b0
ToppCell	BAL-Control-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPAG4 CD19 IGHG3 IGHG4 HID1	2.46e-05	170	90	5	7dcb6319ba4d7b258dd0a17449d837800ef46ccc
ToppCell	BAL-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPAG4 CD19 IGHG3 IGHG4 HID1	2.46e-05	170	90	5	7377e59fba4bf97ba893ccf6b5e149b5152407be
ToppCell	BAL-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPAG4 CD19 IGHG3 IGHG4 HID1	2.46e-05	170	90	5	e18211029e9ffad54458fd921f455172aad407c7
ToppCell	Control-B_cell-Plasmablast\|Control / Disease group,lineage and cell class （2021.01.30）	SPAG4 CD19 IGHG3 IGHG4 HID1	2.53e-05	171	90	5	c09afc4b111b2b5acca75177554f6364ee02d37c
ToppCell	10x5'-Lung-Lymphocytic_B_plasma\|Lung / Manually curated celltypes from each tissue	SPAG4 CD19 IGHG3 IGHG4 HID1	2.60e-05	172	90	5	8156fb6de66a4c92ade703b71c2e9187291e50ef
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPAG4 KITLG FAM78B AFDN PCDHA2	2.60e-05	172	90	5	490745024730df6357f6c2b81d7a64e21557c0d5
ToppCell	droplet-Fat-Scat-21m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPP4 AFDN LIMCH1 RAPGEF2 NEB	2.68e-05	173	90	5	f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
ToppCell	10x5'-bone_marrow-Lymphocytic_B_plasma-Plasma_cells\|bone_marrow / Manually curated celltypes from each tissue	SPAG4 PLPP5 IGHG3 IGHG4 HID1	2.68e-05	173	90	5	300904fd35536a69be81d76fe33fe16544523ceb
ToppCell	Plasma_cells\|World / lung cells shred on cell class, cell subclass, sample id	ADGRG5 SPAG4 PLPP5 IGHG3 IGHG4	2.68e-05	173	90	5	52a387e2a4694af61a9223a4c2ecf4e6f762c064
ToppCell	10x5'-bone_marrow-Lymphocytic_B_plasma\|bone_marrow / Manually curated celltypes from each tissue	SPAG4 PLPP5 IGHG3 IGHG4 HID1	2.75e-05	174	90	5	b1931028cf80af5eff6da15d7f0196205f17926f
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	MAP2 AFDN LIMCH1 NRG3 PAPSS2	2.75e-05	174	90	5	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	10x5'-blood-Lymphocytic_B_plasma-Plasmablasts\|blood / Manually curated celltypes from each tissue	PLPP5 IGHG3 IGHG4 HID1 E2F8	2.83e-05	175	90	5	2e048bf7961c3d86b6e12a1ebae3b3f2359af457
ToppCell	3'_v3-bone_marrow-Lymphocytic_B_plasma-Plasma_cells\|bone_marrow / Manually curated celltypes from each tissue	SPAG4 PLPP5 IGHG3 IGHG4 HID1	2.83e-05	175	90	5	51301f3f44d3e88397f367cedd1e2abaa2be4c6f
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-Plasma_B-Plasma_B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SPAG4 PLPP5 IGHG3 IGHG4 ABCA8	2.91e-05	176	90	5	67d6dc38708692f8c58cea5ed896f10718e9ffa6
ToppCell	Adult-Immune-B_cell\|Adult / Lineage, Cell type, age group and donor	ADGRG5 PLPP5 CD19 IGHG3 IGHG4	2.91e-05	176	90	5	4aa00dcde907ad83d3aa4bb10439b7b5c4be1e5d
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-Plasma_B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SPAG4 PLPP5 IGHG3 IGHG4 ABCA8	2.91e-05	176	90	5	125be81311f87563ca321472fcce6e0e0ae24c16
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122\|Adult / Lineage, Cell type, age group and donor	FAT1 KITLG LIPH ZNF385B LIMCH1	2.91e-05	176	90	5	3fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell	BAL-Control-Lymphocyte-B\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPAG4 CD19 IGHG3 IGHG4 HID1	2.91e-05	176	90	5	7c1ecec45b5fe5e73cbce0fadca726ffd10c0316
ToppCell	(2)_Plasma_cells\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	SPAG4 PLPP5 IGHG3 IGHG4 HID1	2.99e-05	177	90	5	ed3c936bb69f9bc7291b4f6cde1d204078117c48
ToppCell	VE-plasma\|VE / Condition, Cell_class and T cell subcluster	SPAG4 CD19 IGHG3 IGHG4 HID1	2.99e-05	177	90	5	0c1cc0834de55717cb4f69d020339060ce2c9a03
ToppCell	VE-plasma-\|VE / Condition, Cell_class and T cell subcluster	SPAG4 CD19 IGHG3 IGHG4 HID1	2.99e-05	177	90	5	3a3c94cf30012e2aa266bc4d7fe772e45fa90f6d
ToppCell	IPF-Myeloid-pDC\|Myeloid / Disease state, Lineage and Cell class	ADGRG5 PLXNA4 RET RAPGEF2 KLHDC4	3.24e-05	180	90	5	0f8567aa835d4e3a52f6631ae15216eca18a030c
ToppCell	BLOOD--(5)_Plasma\| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SPAG4 PLPP5 IGHG3 IGHG4 HID1	3.24e-05	180	90	5	1ac0a0a715f4a36df0762bb0de44802d6ffa284c
ToppCell	cellseq-Immune-Lymphocytic_B-Lymphocytic_B\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SPAG4 PLPP5 CD19 IGHG3 IGHG4	3.24e-05	180	90	5	cd04d7bf92986a5b8a0193c9b92ec47da3929bac
ToppCell	BLOOD--(5)_Plasmablasts\| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SPAG4 PLPP5 IGHG3 IGHG4 HID1	3.24e-05	180	90	5	4b9be1b19d4ecd0a3b924e4557a1ecfbcff2d705
ToppCell	cellseq-Immune-Lymphocytic_B\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SPAG4 PLPP5 CD19 IGHG3 IGHG4	3.24e-05	180	90	5	663a800ab70e7ab7d13183417f9c1ed36907aa5e
ToppCell	BAL-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPAG4 CD19 IGHG3 IGHG4 HID1	3.24e-05	180	90	5	6a777a308fa3160d31eda468db930e71862020b2
ToppCell	AT1_cells-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	GRAMD2A MAP2 LIMCH1 PAPSS2 ABCA8	3.24e-05	180	90	5	ff4728782c3ec814ba071cc22b7894abdd9da837
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA2 ANK2 MAP2 NBEA RET	3.41e-05	182	90	5	be32b5b8153c1053cbb55f1fccfa27c3ee97c1e1
ToppCell	severe_influenza-B_intermediate\|World / disease group, cell group and cell class (v2)	GRAMD2A ANK2 CD19 IGHG3 IGHG4	3.41e-05	182	90	5	e633a908a2fb30ed362cf22fbb8d6839f31f1751
ToppCell	COVID-19-lung-AT1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GRAMD2A MAP2 LIPH ZNF385B LIMCH1	3.50e-05	183	90	5	7b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCell	368C-Lymphocytic-Plasma_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SPAG4 PLPP5 IGHG3 IGHG4 HID1	3.50e-05	183	90	5	7733cf919eda146efe41c93990658ce92db73aa8
ToppCell	368C-Lymphocytic-Plasma_cell-\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SPAG4 PLPP5 IGHG3 IGHG4 HID1	3.50e-05	183	90	5	d91441cbf94f5c3b7c36f2ca3a46895870bd730f
ToppCell	B_cell_maturation-plasma\|World / Lineage and Cell class	SPAG4 PLPP5 IGHG3 IGHG4 HID1	3.50e-05	183	90	5	0c3cb61912df05f1beba1004540770ef1a4de786
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ANK2 CD19 IGHG3 IGHG4 NEB	3.50e-05	183	90	5	01664fce6b70a02c9d39d747b6a6aabc86d57bc2
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GRAMD2A MAP2 AFDN LIMCH1 NRG3	3.59e-05	184	90	5	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	367C-Lymphocytic-Plasma_cell-\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SPAG4 PLPP5 IGHG3 IGHG4 HID1	3.59e-05	184	90	5	14a5288d861260f63fbe0cbea3569cf643e7597e
ToppCell	10x5'-Liver-Lymphocytic_B_plasma-Plasma_cells\|Liver / Manually curated celltypes from each tissue	SPAG4 PLPP5 IGHG3 IGHG4 HID1	3.59e-05	184	90	5	6f70d8f8ab8362d51f8a58735d42223e06566397
ToppCell	367C-Lymphocytic-Plasma_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SPAG4 PLPP5 IGHG3 IGHG4 HID1	3.59e-05	184	90	5	fc708a5c8a7b19fab973c72dc4383a7d30f8b59a
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GRAMD2A MAP2 AFDN LIMCH1 NRG3	3.59e-05	184	90	5	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	FAT1 KITLG LIPH ZNF385B LIMCH1	3.69e-05	185	90	5	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	ADGRG5 SPAG4 CD19 IGHG3 IGHG4	3.69e-05	185	90	5	10f7e5daf8e95dda9453212e84b64874f4e0d7ab
ToppCell	Mesenchymal_cells-Osteo-CAR\|World / Lineage and Cell class	FAT1 KITLG FAM78B LIMCH1 KNG1	3.69e-05	185	90	5	16f1588893d09c864e0cb4f837a1b972a1a57baa
ToppCell	normal_Lung-B_lymphocytes-MALT_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	SPAG4 PLPP5 IGHG3 IGHG4 HID1	3.78e-05	186	90	5	f4d72463c5f287da6436287eda0a349b4185841e
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KITLG AFDN LIMCH1 HID1 TRIM37	3.78e-05	186	90	5	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	IPF-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	SPAG4 PLPP5 IGHG3 IGHG4 E2F8	3.78e-05	186	90	5	f9c21daf905d0bb0e0e769ca4bb069ea4b1ba25b
ToppCell	Epithelial-alveolar_epithelial_cell_type_1\|World / Lineage, Cell type, age group and donor	MAP2 LIPH AFDN LIMCH1 NRG3	3.78e-05	186	90	5	09d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCell	Control-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	SPAG4 PLPP5 IGHG3 IGHG4 HID1	3.78e-05	186	90	5	a08a50bff4e629588faa22440d57334b1df0e8df
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NFASC NBEA RET ABCA8 GULP1	3.88e-05	187	90	5	dfc2b95d70daf533bc0cc4ce78af9f65dd75a25b
ToppCell	B_cells-Plasma_cells_and_plasmablasts\|World / Immune cells in Kidney/Urine in Lupus Nephritis	SPAG4 PLPP5 IGHG3 IGHG4 HID1	3.88e-05	187	90	5	9325cadd5f2c667d526696899e7aa36a98226d4b
ToppCell	severe_influenza-B_intermediate\|severe_influenza / disease group, cell group and cell class (v2)	GRAMD2A ANK2 CD19 IGHG3 IGHG4	3.88e-05	187	90	5	d6db8595aa72fdabc4a056ba6ce09876868a66d5
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GRAMD2A MAP2 LIMCH1 NRG3 PAPSS2	3.88e-05	187	90	5	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPAG4 PLPP5 CD19 IGHG3 IGHG4	3.88e-05	187	90	5	8089ae6ee59533a090fe0b19bdd057fba8fa11de
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-Plasma_cells\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	ADGRG5 SPAG4 IGHG3 IGHG4	3.98e-05	94	90	4	4b6623de5a517ebf5df865e0dcd615111622ad3e
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_B_plasma-Plasma_cells\|lymph-node_spleen / Manually curated celltypes from each tissue	SPAG4 PLPP5 IGHG3 IGHG4 HID1	3.98e-05	188	90	5	c7b1807c96f87fbcd37739a159cf00f9a1ff5d71
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	8.20e-06	2	85	2	DOID:0110471 (implicated_via_orthology)
Disease	sarcoplasmic/endoplasmic reticulum calcium ATPase 3 measurement	PCIF1 SERPINA10	2.46e-05	3	85	2	EFO_0802036
Disease	Colorectal Carcinoma	SHANK1 FAT1 ATP7B ANK2 MAP2 NPAP1 ABCC5 RET ABCA8 SMAD2	3.42e-05	702	85	10	C0009402
Disease	breast carcinoma (is_marker_for)	ATP7B NCOA1 AFDN SMAD2	4.03e-05	66	85	4	DOID:3459 (is_marker_for)
Disease	Nonsyndromic Deafness	KITLG TPRN STRC OTOG	9.01e-05	81	85	4	C3711374
Disease	triglycerides to total lipids in medium HDL percentage	PCIF1 ABCA8 TP53BP1	5.73e-04	56	85	3	EFO_0022333
Disease	cholesterol to total lipids in medium HDL percentage	PCIF1 ABCA8 TP53BP1	7.01e-04	60	85	3	EFO_0022237
Disease	triglycerides to total lipids in small HDL percentage	PCIF1 ABCA8 TP53BP1	1.19e-03	72	85	3	EFO_0022336
Disease	Colorectal Neoplasms	FAT1 ATP7B ABCC5 RET ABCA8	1.25e-03	277	85	5	C0009404
Disease	post-traumatic stress disorder symptom measurement	CPA5 NBEA PCDHA2	1.73e-03	82	85	3	EFO_0008535
Disease	response to clopidogrel, cardiovascular event measurement	NCOA2 CRTAC1	1.99e-03	23	85	2	EFO_0006919, GO_1903493
Disease	mean reticulocyte volume	ADGRG5 PCIF1 AFDN AKAP13 KBTBD2 NEB TRIM37 E2F8	2.14e-03	799	85	8	EFO_0010701

Protein segments in the cluster

Peptide	Gene	Start	Entry
VIFIPESFMPSRSPC	BTN2A3P	231	Q96KV6
FTFPASKSQDRMAPP	AFDN	1231	P55196
TVPFDSESPIRMKFT	ATAD5	646	Q96QE3
AMVFKPSPFTPVSAL	ALDH9A1	176	P49189
PTLPFVKTVPTTIMA	ADGRG4	1651	Q8IZF6
AERSPVTFFDTPPML	ATP7B	756	P35670
TPYFKASARVVMPPI	FAM78B	46	Q5VT40
HTKLMRIPSFFPSPE	AKAP13	2691	Q12802
PIFPMTVKTIRFPES	PCDHA2	131	Q9Y5H9
LASDPLTPEFIKPTM	NR4A1	21	P22736
LTPEFIKPTMDLASP	NR4A1	26	P22736
PFTESKSKIPVRTMP	ANK2	3296	Q01484
DPFFLSKPSSFPKAM	NRG3	111	P56975
ISEFAPPNTPVVMVK	FAT1	376	Q14517
LDPKSTIVAIFPSPM	PAPSS2	471	O95340
PSLPVDMRVPFSELK	CPA5	76	Q8WXQ8
FPMPFISAKSSPVIP	FCAR	26	P24071
MIKIPSDTFTIIPDF	PLXNA4	226	Q9HCM2
MIFTPFLPPADLSVF	FAM236A	1	A0A1B0GUQ0
LPMPTKRRSTFVQSP	DIP2B	121	Q9P265
FPKTPMLFVRIKPSL	KBTBD2	361	Q8IY47
TIMFKVVPVSDPPVN	MPP4	226	Q96JB8
RKVPAESMPTLTPAF	KDM3B	591	Q7LBC6
SRMRPHIFTLSVPFP	LAGE3	56	Q14657
PPMTKAFFDTAEESP	LIPH	311	Q8WWY8
RHPISKILSPVMTFP	MRGPRX3	91	Q96LB0
ETVLSLEFPFPKPDM	POGK	81	Q9P215
FSFPAAKPKEPTMVA	INF2	606	Q27J81
PAASSASPMFKPIFT	POM121C	696	A8CG34
LRSPMKFFDTTPTGR	ABCC5	956	O15440
AFVSVLDVPPRMLSP	NFASC	421	O94856
VPTPPEDFAVFATMK	DNAH6	766	Q9C0G6
PPTPALTRMEQSRFK	PCIF1	591	Q9H4Z3
PSFHVTPLKLMVSPT	E2F8	691	A0AVK6
MRTVPGPLFTDFVRP	DMRTB1	181	Q96MA1
MTDPTRRFFKVTPPP	CD19	326	P15391
MIFTPFLPPADLSVF	FAM236B	1	A0A1B0GV22
IMEKTQSLPTRPPTF	COL14A1	1001	Q05707
SPSTDIFDMIPFSPI	GULP1	211	Q9UBP9
VPNVLTFDFMSKPSP	DHX33	451	Q9H6R0
IPASFGTRAPPMVRK	ABCA2	1706	Q9BZC7
FRETPLPIDPSMFPT	CDK11A	711	Q9UQ88
VKPTPRSGFSVAMAP	KLHDC4	291	Q8TBB5
SPIPRRPTQSFVKFM	KIAA1210	1186	Q9ULL0
ISLMKRPPGFSPFRS	KNG1	376	P01042
FRDIASPKFSMPSPV	CRTAC1	331	Q9NQ79
SPKFSMPSPVRTVIT	CRTAC1	336	Q9NQ79
FLFPPKPKDTLMISR	IGHG3	171	P01860
FLFPPKPKDTLMISR	IGHG4	121	P01861
SLPVFAFIMTKFRPV	METTL13	201	Q8N6R0
MIFTPFLPPADLSVF	FAM236C	1	P0DP71
MIFTPFLPPADLSVF	FAM236D	1	A0A1B0GTK5
TDSFFPSRKPPMSEK	GRAMD2A	236	Q8IUY3
FTILAKMSLPSVPVF	BBS1	236	Q8NFJ9
LSASFAFMLPVATPP	SLC13A5	496	Q86YT5
VPFVPMTLPTKVLSA	PHKA2	711	P46019
PEATLTFPFLDKMPE	LIMCH1	721	Q9UPQ0
PSSEKSPVMTPQFKF	LIMCH1	751	Q9UPQ0
PAPRFPLMTKAVTVR	OTOG	1621	Q6ZRI0
PVVVPFPTMTFAEVL	DARS2	311	Q6PI48
VHRKPMASFVTTPVP	TRIM37	251	O94972
PRPPAITGVESFMTK	NCOA1	251	Q15788
SPGPRTTMFRIPEFK	NBEA	1321	Q8NFP9
KPYSIRVPMDIPVFT	HID1	441	Q8IV36
TAIFPRFSKPAPMFL	ST3GAL3	96	Q11203
RVSVTKPFMLPPVAA	KITLG	176	P21583
SFKPPVTRESPISMC	NPAP1	506	Q9NZP6
MPPPRVFKSFLSLLF	SPAG4	126	Q9NPE6
FMKFRVPAPFPSLTK	SIX6OS1	166	Q8N1H7
IPFLAVSDLMRFPPS	STRC	806	Q7RTU9
LAPPAMKFSRSLSVP	SHANK1	901	Q9Y566
IPFIFTFLIPPATMI	ABCA8	1161	O94911
FPKLMVPRFSFPAPS	AHNAK2	5386	Q8IVF2
IAFLLSPAFAMSPVP	ADGRG5	296	Q8IZF4
PPLKFTAPSMASVLE	CLUH	1221	O75153
VPMKERPVLPSSESF	NCOA2	256	Q15596
MTLTKPSREAPLPFI	RAPGEF2	386	Q9Y4G8
MSSILPFTPPVVKRL	SMAD2	1	Q15796
PTKPMFVIAFLSPLS	PLPP5	56	Q8NEB5
PARSEDMPFSPKASV	TP53BP1	256	Q12888
PSLDIKPFMSFPVDS	ZNF385B	106	Q569K4
EPSSPQERMFTIDPK	MAP2	651	P11137
KPPISSAEMTFRRPA	RET	666	P07949
TPPPTFSFRERMTHK	ZDHHC16	251	Q969W1
TAYSMPPVIKVDRPF	SERPINA10	406	Q9UK55
MNVSSVVKPSFFPLP	ZNF844	476	Q08AG5
PPSRVSPFKDMILCF	ZNF496	216	Q96IT1
SFEIRPAPKPVMETI	TPRN	296	Q4KMQ1
IPFLAVSDLMRFPPS	STRCP1	806	A6NGW2
SSDPKVLTLFMAVPP	TRIM22	426	Q8IYM9
KVPLFMSRAPSEIDP	TTC4	41	O95801
VPVPMFLPTTLESTD	ZMYM3	896	Q14202
FMNIIPTKETPPTRI	ATP6V0A2	356	Q9Y487
ARPIFFTPKDNMSIP	MYO9A	1666	B2RTY4
KATPTPFTPEMERVK	NEB	6346	P20929