Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncarbohydrate kinase activity

HK1 PFKFB3 PFKFB4

4.20e-0521653GO:0019200
GeneOntologyMolecularFunction6-phosphofructo-2-kinase activity

PFKFB3 PFKFB4

6.23e-054652GO:0003873
GeneOntologyMolecularFunctionfructose-2,6-bisphosphate 2-phosphatase activity

PFKFB3 PFKFB4

1.04e-045652GO:0004331
GeneOntologyMolecularFunctionphosphofructokinase activity

PFKFB3 PFKFB4

2.17e-047652GO:0008443
GeneOntologyMolecularFunctionsugar-phosphatase activity

PFKFB3 PFKFB4

4.62e-0410652GO:0050308
GeneOntologyMolecularFunctioncarbohydrate phosphatase activity

PFKFB3 PFKFB4

5.63e-0411652GO:0019203
GeneOntologyCellularComponentCLOCK-BMAL transcription complex

CLOCK NPAS2

9.76e-055662GO:1990513
DomainEnvoplakin

EVPLL EVPL

1.27e-052672IPR030460
Domain6Pfruct_kin

PFKFB3 PFKFB4

7.57e-054672IPR003094
Domain6Phosfructo_kin

PFKFB3 PFKFB4

7.57e-054672IPR013079
Domain6PF2K

PFKFB3 PFKFB4

7.57e-054672PF01591
DomainPrprotnconvertsP

PCSK2 PCSK7

2.63e-047672IPR002884
DomainP_proprotein

PCSK2 PCSK7

2.63e-047672PF01483
DomainS8_pro-domain

PCSK2 PCSK7

2.63e-047672IPR032815
Domain-

PCSK2 PCSK7

2.63e-0476723.30.70.850
DomainS8_pro-domain

PCSK2 PCSK7

2.63e-047672PF16470
DomainNuc_translocat

CLOCK NPAS2

3.50e-048672IPR001067
DomainPeptidase_S8_His-AS

PCSK2 PCSK7

4.49e-049672IPR022398
DomainPG/BPGM_mutase_AS

PFKFB3 PFKFB4

4.49e-049672IPR001345
DomainPeptidase_S8_Ser-AS

PCSK2 PCSK7

4.49e-049672IPR023828
DomainPeptidase_S8_subtilisin-rel

PCSK2 PCSK7

5.60e-0410672IPR015500
DomainPGAM

PFKFB3 PFKFB4

5.60e-0410672SM00855
DomainSUBTILASE_ASP

PCSK2 PCSK7

5.60e-0410672PS00136
DomainSUBTILASE_HIS

PCSK2 PCSK7

5.60e-0410672PS00137
DomainSUBTILASE_SER

PCSK2 PCSK7

5.60e-0410672PS00138
DomainPG_MUTASE

PFKFB3 PFKFB4

5.60e-0410672PS00175
Domain-

PCSK2 PCSK7

6.83e-04116723.40.50.200
DomainPeptidase_S8/S53_dom

PCSK2 PCSK7

6.83e-0411672IPR000209
DomainPeptidase_S8

PCSK2 PCSK7

6.83e-0411672PF00082
DomainHis_Phos_1

PFKFB3 PFKFB4

8.18e-0412672PF00300
DomainHis_Pase_superF_clade-1

PFKFB3 PFKFB4

8.18e-0412672IPR013078
DomainDynein_heavy_chain_D4_dom

DNAH6 DNAH11

1.12e-0314672IPR024317
DomainDynein_HC_stalk

DNAH6 DNAH11

1.12e-0314672IPR024743
DomainDynein_heavy_dom-2

DNAH6 DNAH11

1.12e-0314672IPR013602
DomainDHC_N2

DNAH6 DNAH11

1.12e-0314672PF08393
DomainMT

DNAH6 DNAH11

1.12e-0314672PF12777
DomainAAA_8

DNAH6 DNAH11

1.12e-0314672PF12780
DomainATPase_dyneun-rel_AAA

DNAH6 DNAH11

1.12e-0314672IPR011704
DomainAAA_5

DNAH6 DNAH11

1.12e-0314672PF07728
DomainDHC_fam

DNAH6 DNAH11

1.29e-0315672IPR026983
DomainDynein_heavy_dom

DNAH6 DNAH11

1.29e-0315672IPR004273
DomainDynein_heavy

DNAH6 DNAH11

1.29e-0315672PF03028
DomainPropept_inh

PCSK2 PCSK7

1.67e-0317672IPR009020
Domain-

EPHB4 PCSK2 PCSK7

2.29e-03736732.60.120.260
DomainHis_PPase_superfam

PFKFB3 PFKFB4

2.31e-0320672IPR029033
Domain-

PFKFB3 PFKFB4

2.31e-03206723.40.50.1240
DomainFG_GAP

ITFG2 ITGA8

2.80e-0322672PS51470
DomainPAS_fold_3

CLOCK NPAS2

3.06e-0323672IPR013655
DomainPAS_3

CLOCK NPAS2

3.06e-0323672PF08447
DomainFG-GAP

ITFG2 ITGA8

3.33e-0324672PF01839
DomainFG-GAP

ITFG2 ITGA8

3.33e-0324672IPR013517
DomainPAS

CLOCK NPAS2

3.61e-0325672PF00989
DomainPAS_fold

CLOCK NPAS2

3.61e-0325672IPR013767
DomainPAC

CLOCK NPAS2

3.90e-0326672IPR001610
DomainPAC

CLOCK NPAS2

3.90e-0326672SM00086
DomainPAC

CLOCK NPAS2

3.90e-0326672PS50113
DomainGalactose-bd-like

EPHB4 PCSK2 PCSK7

4.69e-0394673IPR008979
DomainSpectrin/alpha-actinin

EVPLL EVPL

5.87e-0332672IPR018159
DomainPAS

CLOCK NPAS2

5.87e-0332672SM00091
DomainSPEC

EVPLL EVPL

5.87e-0332672SM00150
DomainPAS

CLOCK NPAS2

6.60e-0334672IPR000014
DomainPAS

CLOCK NPAS2

6.60e-0334672PS50112
DomainCadherin_CS

FAT1 FAT3 PCDH10

7.07e-03109673IPR020894
Pubmed

PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma.

CUL1 PFKFB3 PFKFB4

3.98e-07868336115843
Pubmed

Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.

HK1 PFKFB3 PFKFB4

5.95e-07968321074528
Pubmed

Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1.

HK1 PFKFB3 PFKFB4

8.49e-071068325974097
Pubmed

Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.

CLOCK EP300 NPAS2

1.55e-061268314645221
Pubmed

Loss of PFKFB4 induces cell death in mitotically arrested ovarian cancer cells.

PFKFB3 PFKFB4

3.77e-06268228152500
Pubmed

Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta.

PFKFB3 PFKFB4

3.77e-0626828830046
Pubmed

Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation.

PFKFB3 PFKFB4

3.77e-06268216311927
Pubmed

Overexpression of Protein Phosphatase 2 Regulatory Subunit B"Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma.

PPP2R3A HK1

3.77e-06268235945177
Pubmed

Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia.

CLOCK NPAS2

3.77e-06268224824748
Pubmed

Ciliary Hedgehog signaling regulates cell survival to build the facial midline.

TMEM231 PTCH1 TUBG1

6.77e-061968334672258
Pubmed

Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo.

PFKFB3 PFKFB4

1.13e-05368214623077
Pubmed

NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators.

CLOCK NPAS2

1.13e-05368226895328
Pubmed

Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.

PCSK2 PCSK7

1.13e-05368222396549
Pubmed

Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia.

PFKFB3 PFKFB4

1.13e-05368230819197
Pubmed

Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study.

PCSK2 PCSK7

1.13e-05368212358783
Pubmed

Peripheral circadian oscillators require CLOCK.

CLOCK NPAS2

1.13e-05368217637349
Pubmed

Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors.

CLOCK NPAS2

1.13e-05368211441146
Pubmed

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.

CLOCK NPAS2

1.13e-05368224270424
Pubmed

Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes.

FAT1 FAT3

1.13e-05368215744052
Pubmed

CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock.

CLOCK NPAS2

1.13e-05368217417633
Pubmed

Circadian variation of blood pressure and the vascular response to asynchronous stress.

CLOCK NPAS2

1.13e-05368217360665
Pubmed

Association of Per1 and Npas2 with autistic disorder: support for the clock genes/social timing hypothesis.

CLOCK NPAS2

1.13e-05368217264841
Pubmed

Association of CLOCK, ARNTL, and NPAS2 gene polymorphisms and seasonal variations in mood and behavior.

CLOCK NPAS2

1.13e-05368226134245
Pubmed

Mutations in CREBBP and EP300 genes affect DNA repair of oxidative damage in Rubinstein-Taybi syndrome cells.

OGG1 EP300

1.13e-05368231504229
Pubmed

Breast cancer risk, nightwork, and circadian clock gene polymorphisms.

CLOCK NPAS2

1.13e-05368224919398
Pubmed

Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.

PFKFB3 PFKFB4

1.13e-05368217143338
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

EPHB4 CUL1 HK1 KCTD5 DAPK2 PCSK7 EP300 SEMA4G DNAH11

1.23e-0573068934857952
Pubmed

Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines.

PFKFB3 PFKFB4

2.25e-0546829464277
Pubmed

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme.

PFKFB3 PFKFB4

2.25e-0546827574501
Pubmed

CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcription.

CLOCK EP300

2.25e-05468219922678
Pubmed

Functionally Complete Excision of Conditional Alleles in the Mouse Suprachiasmatic Nucleus by Vgat-ires-Cre.

CLOCK NPAS2

2.25e-05468229671710
Pubmed

[EXPRESSION OF PFKFB, HK2, NAMPT, TSPAN13 AND HSPB8 GENES IN PEDIATRIC GLIOMA].

PFKFB3 PFKFB4

2.25e-05468227491149
Pubmed

Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes.

CLOCK NPAS2

2.25e-05468219829696
Pubmed

Genetic components of the circadian clock regulate thrombogenesis in vivo.

CLOCK NPAS2

2.25e-05468218413500
Pubmed

Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.

PFKFB3 PFKFB4

2.25e-05468210095107
Pubmed

ARNTL (BMAL1) and NPAS2 gene variants contribute to fertility and seasonality.

CLOCK NPAS2

2.25e-05468220368993
Pubmed

Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase.

PFKFB3 PFKFB4

2.25e-0546822837207
Pubmed

Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis.

TUBG1 DNAH11

3.75e-05568218729223
Pubmed

Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators.

CLOCK NPAS2

3.75e-05568218316400
Pubmed

The centrosomal E3 ubiquitin ligase FBXO31-SCF regulates neuronal morphogenesis and migration.

CUL1 TUBG1

3.75e-05568223469015
Pubmed

CLOCK gene variants associate with sleep duration in two independent populations.

CLOCK NPAS2

3.75e-05568220149345
Pubmed

Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock.

CLOCK NPAS2

3.75e-05568211439184
Pubmed

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.

PCSK2 PCSK7

5.62e-0566828940009
Pubmed

Identification of positional candidate genes for body weight and adiposity in subcongenic mice.

PCSK2 CFAP61

5.62e-05668217536020
Pubmed

Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock.

CLOCK EP300

5.62e-05668220930143
Pubmed

Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron.

CUL1 EP300

5.62e-05668228883095
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

CUL1 FAT1 SCAPER AKAP13 RPRD2 TUBG1 DNAH11 WDR48

5.91e-0568968836543142
Pubmed

Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.

PTCH1 TUBG1 DNAH11

6.71e-054068332317081
Pubmed

The trophoblast clock controls transport across placenta in mice.

CLOCK NPAS2

7.86e-05768233913482
Pubmed

The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate.

PFKFB3 PFKFB4

7.86e-05768215896703
Pubmed

Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.

FAT1 FAT3

7.86e-05768222510986
Pubmed

Proteolytic processing in the secretory pathway.

PCSK2 PCSK7

7.86e-05768210409610
Pubmed

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.

PCSK2 PCSK7

7.86e-0576827819324
Pubmed

Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.

FAT1 FAT3

7.86e-05768216059920
Pubmed

The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors.

CLOCK NPAS2

7.86e-0576829576906
Pubmed

PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.

CUL1 EP300

7.86e-05768218809579
Pubmed

Transcriptional architecture and chromatin landscape of the core circadian clock in mammals.

CLOCK NPAS2

7.86e-05768222936566
Pubmed

The methamphetamine-sensitive circadian oscillator does not employ canonical clock genes.

CLOCK NPAS2

1.05e-04868219204282
Pubmed

Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.

PCSK2 PCSK7

1.05e-0486829885250
Pubmed

Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.

PCSK2 PCSK7

1.05e-04868210037747
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

CUL1 RPL31 NOP58 KCTD5 SCAPER PFKFB3 PCDH10 NKRF CDC23

1.12e-0497168933306668
Pubmed

The activation and physiological functions of the proprotein convertases.

PCSK2 PCSK7

1.34e-04968218343183
Pubmed

The prohormone theory and the proprotein convertases: it is all about serendipity.

PCSK2 PCSK7

1.34e-04968221805236
Pubmed

The proprotein convertases, 20 years later.

PCSK2 PCSK7

1.34e-04968221805237
Pubmed

The biology and therapeutic targeting of the proprotein convertases.

PCSK2 PCSK7

1.34e-04968222679642
Pubmed

The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.

PCSK2 PCSK7

1.34e-04968223775089
Pubmed

GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

PTCH1 TUBG1

1.34e-04968223446420
Pubmed

Autonomous and non-cell autonomous role of cilia in structural birth defects in mice.

PTCH1 TUBG1

1.34e-04968238079449
Pubmed

The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.

RPL31 NOP58 LAP3 NKRF TUBG1

1.40e-0425368529911972
Pubmed

Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

NOP58 LAP3 EP300 CDC23 WDR48

1.51e-0425768530945288
Pubmed

Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.

PCSK2 PCSK7

1.68e-041068216163737
Pubmed

Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.

CLOCK NPAS2

1.68e-041068216528748
Pubmed

Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling.

PTCH1 DNAH11

1.68e-041068221098568
Pubmed

Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice.

EPHB4 PTCH1

1.68e-041068218568073
Pubmed

Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study.

CLOCK NPAS2

1.68e-041068219934327
Pubmed

Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination.

PKD1 DNAH11

2.05e-041168227272319
Pubmed

Primary cilia are critical for tracheoesophageal septation.

PTCH1 TUBG1

2.05e-041168237776236
Pubmed

Loss of ciliary transition zone protein TMEM107 leads to heterotaxy in mice.

PTCH1 DNAH11

2.45e-041268231887266
Pubmed

Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate.

PTCH1 TUBG1

2.45e-041268228069795
Pubmed

Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells.

PTCH1 TUBG1

2.45e-041268223918393
Pubmed

Nubp2 is required for cranial neural crest survival in the mouse.

PTCH1 TUBG1

2.45e-041268231733190
Pubmed

The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5.

PTCH1 TUBG1

2.45e-041268230931988
Pubmed

Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling.

PTCH1 TUBG1

2.90e-041368224853502
Pubmed

Hypoxia-mediated promotion of glucose metabolism in non-small cell lung cancer correlates with activation of the EZH2/FBXL7/PFKFB4 axis.

PFKFB4 WDR48

2.90e-041368237179372
Pubmed

SHH E176/E177-Zn2+ conformation is required for signaling at endogenous sites.

PTCH1 TUBG1

2.90e-041368228263766
Pubmed

Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation.

RPL31 HK1 PES1 AKAP13 TUBG1

3.33e-0430568521244100
Pubmed

A hypomorphic allele reveals an important role of inturned in mouse skeletal development.

PTCH1 TUBG1

3.38e-041468225774014
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH6 DNAH11

3.38e-04146829373155
Pubmed

The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway.

PTCH1 TUBG1

3.89e-041568226035863
Pubmed

Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation.

PTCH1 EP300

3.89e-041568214517255
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

CUL1 TPR RPL31 USP32 SCAPER PCDH10 NKRF RFWD3

4.29e-0492268827609421
Pubmed

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning.

PTCH1 TUBG1

4.44e-041668218272593
Pubmed

PER2 variantion is associated with depression vulnerability.

CLOCK NPAS2

4.44e-041668219693801
Pubmed

Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.

PCSK2 PCSK7

4.44e-041668220876279
Pubmed

The ciliopathy gene Rpgrip1l is essential for hair follicle development.

PTCH1 TUBG1

5.03e-041768225398052
Pubmed

Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.

TUBG1 DNAH11

5.03e-041768222357932
Pubmed

Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos.

PTCH1 EP300

5.03e-041768218330926
Pubmed

Multiple essential roles for primary cilia in heart development.

PTCH1 TUBG1

5.03e-041768223351706
Pubmed

Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis.

PTCH1 TUBG1

5.65e-041868234446743
Pubmed

CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.

CLOCK NPAS2

5.65e-041868220180986
GeneFamily6-phosphofructo-2-kinases/fructose-2,6-biphosphatases

PFKFB3 PFKFB4

4.48e-0545021077
GeneFamilyEF-hand domain containing|Plakins

EVPLL EVPL

2.08e-048502939
GeneFamilyProprotein convertase subtilisin/kexin family

PCSK2 PCSK7

2.67e-049502973
GeneFamilyDyneins, axonemal

DNAH6 DNAH11

9.93e-0417502536
GeneFamilyCadherin related

FAT1 FAT3

9.93e-041750224
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

CLOCK EP300

9.93e-0417502486
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T4_reg-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TPR NOP58 CD6 LRRTM4 PCSK7 ANKRD12

4.76e-07191686c5e22df4a8741b8096cdd1618271fd48d6265846
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM231 PZP DNAH6 SEC14L4 DNAH11

6.07e-0616968514aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TMEM231 PZP DNAH6 SEC14L4 DNAH11

9.41e-061856855e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

NIBAN1 PPP2R3A DAPK2 CFAP61 NPAS2

1.04e-051896859c1debd65c13d63fd4f3158917d621b44b714c26
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 FAT3 PFKFB3 DNAH6 DNAH11

1.04e-05189685904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellCOPD-Lymphoid-T_Cytotoxic|Lymphoid / Disease state, Lineage and Cell class

NIBAN1 CD6 DAPK2 PFKFB3 PZP

1.07e-0519068510bece40d980d37a01dae8ce887655bf9f93040c
ToppCellIPF-Lymphoid-T_Cytotoxic|Lymphoid / Disease state, Lineage and Cell class

NIBAN1 CD6 DAPK2 PFKFB3 PZP

1.15e-051936853c8a022dbd4f8d25b14fd137ce64c2713a7dbe41
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPL31 NIBAN1 CD6 PCSK7 CCR7

1.15e-051936857022b3ce6220d6d1722a4e2947630a8da002cdce
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPL31 NIBAN1 CD6 PCSK7 CCR7

1.15e-051936853083305b7ae09a37d7f45b915d49b2b396276822
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPL31 NIBAN1 CD6 PCSK7 CCR7

1.15e-051936851218e74ee5e00d230222b10acc50cb96201016b4
ToppCellnormal_Lung-T/NK_cells-CD4+_Th|normal_Lung / Location, Cell class and cell subclass

RPL31 NIBAN1 CD6 CCR7 ANKRD12

1.21e-05195685d6c69f149f3d96fe83f920e38277dede102d04b5
ToppCellControl-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

NIBAN1 CD6 DAPK2 AKAP13 PFKFB3

1.21e-051956856687e579582d7a239bee80846de0cf827a6f6a62
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RPL31 CD6 PCSK7 CCR7 ANKRD12

1.21e-0519568553528e5788083bce5a8d4611ab3808878e6a9cd3
ToppCellnormal_Lung-T/NK_cells-CD4+_Th|T/NK_cells / Location, Cell class and cell subclass

NIBAN1 CD6 CCR7 ANKRD12 PFKFB3

1.27e-0519768580b3902ceea242148a1f1707c633f66afedf5183
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP61 TMEM231 DNAH6 SEC14L4 DNAH11

1.37e-05200685af6a551f83808c1c839df7ba7b1702ca28ea6e1b
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP61 TMEM231 PZP DNAH6 DNAH11

1.37e-0520068585c98da55f7cd4ffdf9d309b56c8cc5d43f3c04c
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP61 TMEM231 DNAH6 SEC14L4 DNAH11

1.37e-0520068573ac1cf40ddd764be1100cbfaaa29563665457d8
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP61 TMEM231 PZP DNAH6 DNAH11

1.37e-0520068512bc7d95c4166d12487081a76d210b7abe5991b0
ToppCellILEUM-non-inflamed-(3)_MNP-(3)_moDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SCAPER PCSK7 AKAP13 ANKRD12

5.44e-05135684b7a792a7c0c22d8b703509f134115f0e394d7de0
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NIBAN1 NOP58 LRRTM4 PZP

7.57e-051476849566398275cad79223db90ffe640830acf2db864
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 DAPK2 ITGA8 TUBG1

7.77e-05148684f85dc34f6a4a15ecffa4fbd5644dea12ce30089b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 DAPK2 ITGA8 TUBG1

7.77e-051486844b1fdf90c585f89cee1cf521db4e3fafc9d74d9a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 DAPK2 ITGA8 TUBG1

7.77e-0514868455826b7e9f79ab78a93abd4fc662bc37aa121471
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NOP58 ITFG2 PZP NKRF

7.98e-051496843378d0fe79de6d7879fd48717ded5027593c785f
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

DAPK2 SCAPER PCSK7 ANKRD12

8.40e-05151684999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 SH3PXD2A LRRTM4 FAM135B

1.08e-041616847d1bc73f4c82465b3f489d6737048b0cd54f22cf
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 SH3PXD2A LRRTM4 FAM135B

1.08e-04161684410eef62c83c704cbfc5a1b643c4db11bbdcd81f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 SH3PXD2A LRRTM4 FAM135B

1.08e-0416168471022485da6754a2b57b4c3e758e3de4c95cc292
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 SH3PXD2A LRRTM4 FAM135B

1.08e-0416168459ae8a7c9a04ecaa335b8064852a5a91a21780bd
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPL31 CD6 KCNN1 CCR7

1.18e-04165684567c9f8fe29b5d34c2e39d9a17db54eba51ee559
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPL31 CD6 KCNN1 CCR7

1.18e-04165684cdc05f4a3c2c301f537ae641314875e5ecc16510
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPL31 CD6 KCNN1 CCR7

1.18e-041656842ebabe6fdbcf8765bcf9d98faf20da783c9d113d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 SH3PXD2A LRRTM4 FAM135B

1.21e-04166684f742d15b02a6f651bbd00f53e3d871f40d05a03d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 SH3PXD2A LRRTM4 FAM135B

1.21e-041666840f013bb5fdb72e88c2fc73d60cd01551a2db6341
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 SH3PXD2A LRRTM4 FAM135B

1.21e-04166684e941df9a1091164edde3def8fc7d410186b2bd88
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 SH3PXD2A LRRTM4 FAM135B

1.21e-04166684aeda46bea5d8463c24a83b98b9ed92d962d733e5
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD6 OTUD6B RPRD2 NKRF

1.24e-041676843b717d33aaf1ef0869cc4bca8432ba8008875cc5
ToppCell356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|356C / Donor, Lineage, Cell class and subclass (all cells)

NIBAN1 CD6 AKAP13 PFKFB3

1.27e-041686849d6ca10c272aea28082c09d469940f7232f6461c
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP61 TMEM231 DNAH6 DNAH11

1.30e-04169684fba841664939c771881ba97f14ef1df6635c04ff
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT3 HNF4G DNAH6 DNAH11

1.30e-0416968412bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NIBAN1 FAT3 DAPK2 DNAH6

1.36e-04171684f648789e6aefe508bb748401bf9b3cd830fb0ddf
ToppCell356C-Lymphocytic-ILC-ILC-2|ILC / Donor, Lineage, Cell class and subclass (all cells)

USP32 RPRD2 LCMT2 RFWD3

1.39e-041726844977e1f4deae781750e27a8054deccd336cfb74a
ToppCell356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NIBAN1 CD6 AKAP13 PFKFB3

1.45e-0417468499d7421ad5eafe7751ef90698a92f683aa33bca8
ToppCell10x3'2.3-week_17-19-Lymphocytic_T-T_NK-CD8_T_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RPL31 CD6 CCR7 NPAS2

1.45e-04174684fee2ee3e888ce71f9f3f05d7dc8aaa9549480205
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 FAT3 PFKFB3 DNAH11

1.52e-04176684327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l5|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RPL31 CD6 CCR7 PDE11A

1.55e-04177684f069197d39aacf7ad63be13133a6f3fd35d429ac
ToppCellRSV-Healthy-4|RSV / Virus stimulation, Condition and Cluster

HK1 CCR7 PFKFB3 PFKFB4

1.58e-04178684a5835951492c051443f3c30d45f9a7b1b2557477
ToppCellRSV-Healthy-4|Healthy / Virus stimulation, Condition and Cluster

HK1 CCR7 PFKFB3 PFKFB4

1.58e-04178684a6d71aebb5c462311f8ade24f659642b6b329633
ToppCell367C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DAPK2 PKD1 ITGA8 TMEM231

1.62e-041796845aa8465e943b6b666c7f8b1937fcc3764bfe91f6
ToppCellrenal_papilla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

FAT3 DAPK2 PFKFB3 NPAS2

1.65e-0418068449829e833fe6d2431cfd2e8f378c2aaa3b2b46a4
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CFAP61 TMEM231 DNAH6 DNAH11

1.69e-04181684dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

CFAP61 TMEM231 DNAH6 DNAH11

1.72e-04182684fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellCiliated_cells-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

TMEM231 DNAH6 SEC14L4 DNAH11

1.72e-04182684e93968f800bfeb258e4e834fc8bf92d1cb72cd73
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

FAT3 ITGA8 CFAP61 NKRF

1.72e-04182684ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4-Inhibitory_Neuron.Gad1Gad2.Igfbp4.Rgs4_(Striatum,_interneuron)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CD6 NMUR1 CCR7

1.75e-0471683b0dbb059a7d05f825da608879b23aeebd6e9e61f
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4-Inhibitory_Neuron.Gad1Gad2.Igfbp4.Rgs4_(Striatum,_interneuron)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CD6 NMUR1 CCR7

1.75e-0471683149504ce72da0730074ea436fc2034ce8cb585d5
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP61 TMEM231 DNAH6 DNAH11

1.76e-0418368458847e8f3a7ce3e33adba9477bcd55e769a64a90
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 FAT3 PCDH10 DNAH11

1.80e-041846842cbed6462fea2622871bb7e49b0df3d984239281
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-T-T_CD8-CD8_TRM|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF836 NIBAN1 DAPK2 PCSK7

1.80e-0418468417ffa0e890960c00a3b5fa33d48caba66c61dbb0
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 FAT3 PCDH10 DNAH11

1.80e-04184684ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 FAT3 PCDH10 DNAH11

1.80e-041846842b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFAP61 TMEM231 DNAH6 DNAH11

1.80e-041846845daff849625f2f41d56615569c0ed59cd733b34c
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RPL31 CD6 LRRTM4 CCR7

1.83e-04185684406b52516b26e9fe2c9e768950af447ec7ad5f3e
ToppCell15-Airway-Epithelial-Multiciliated_cell|Airway / Age, Tissue, Lineage and Cell class

CFAP61 DNAH6 SEC14L4 DNAH11

1.83e-041856840998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

CFAP61 TMEM231 DNAH6 DNAH11

1.83e-0418568430f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RPL31 CD6 LRRTM4 CCR7

1.83e-04185684f2ebd099c8dfcfaca4298bcdd618c50701a9c2c8
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

CFAP61 TMEM231 DNAH6 DNAH11

1.83e-0418568418a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NIBAN1 CD6 CCR7 PZP

1.87e-041866849d576dce2c5deefef1adda16c6da7055c8d57f8f
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PTCH1 DNAH11 NPAS2 WDR48

1.87e-0418668477bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A HNF4G FAM135B NPAS2

1.87e-04186684b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

TPR ANKRD12 HNF4G EP300

1.87e-0418668403db813598b67b1e08f759758a1c2023396921fa
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PTCH1 DNAH11 NPAS2 WDR48

1.87e-0418668413bc41c60fd628af31899a5e8b480e06cc4781be
ToppCellCiliated_cells-B-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

TMEM231 PZP DNAH6 DNAH11

1.91e-041876842b4262c2e7c7830a976be168cee6eeb738d4feda
ToppCellsystemic_lupus_erythematosus-flare-Hematopoietic-Progen|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RPL31 CD6 CCR7 PCDH10

1.91e-0418768416fffe894a2c7d5186556ad000e0be229511fbdb
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|368C / Donor, Lineage, Cell class and subclass (all cells)

DAPK2 PTCH1 DNAH11 NPAS2

1.91e-04187684b827d9da7032bf051756ddf88352af922eb0f87b
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|368C / Donor, Lineage, Cell class and subclass (all cells)

DAPK2 PTCH1 DNAH11 NPAS2

1.91e-0418768461c00604dda8b36a5c3eea6554e5601aa1b884f7
ToppCellMild/Remission-B_intermediate-0|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RPL31 PCSK7 CCR7 ANKRD12

1.95e-04188684614032d18f8060bb12d1af7a1cf1cf4d8b2b505b
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFAP61 TMEM231 DNAH6 DNAH11

1.95e-041886842b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T4_reg|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TPR CD6 PCSK7 ANKRD12

1.95e-04188684e5c480b9a030536578f1cc91fb61738f752525b3
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CD6 NMUR1 CCR7

1.98e-047468308874e430b4c9fcb2c1758c4178cb0c45671b125
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFAP61 TMEM231 DNAH6 DNAH11

1.99e-0418968468a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

PPP2R3A DAPK2 AKAP13 CFAP61

1.99e-041896845e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT3 ITGA8 PTCH1 PZP

1.99e-041896842a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCellNS-critical-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EPHB4 GEN1 TUBG1 RFWD3

2.03e-041906847be0f2ff86ca8500a43e0d44e5e292530f9ba0bb
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK2 FAT3 DNAH6 NPAS2

2.03e-0419068449e09cdb843b3d889a06a811aa5affae68b25a75
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

NIBAN1 PPP2R3A DAPK2 AKAP13

2.03e-04190684fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellnucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-CD8_T|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RPL31 NIBAN1 CD6 PZP

2.07e-04191684f7a42a9d7493ea25cd8bd297c22e49e4bad7f0a4
ToppCellLV-06._Ventricular_Cardiomyocyte_II|LV / Chamber and Cluster_Paper

NIBAN1 PPP2R3A DAPK2 AKAP13

2.07e-0419168425f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 PPP2R3A FAT3 PFKFB3

2.07e-04191684d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCelltumor_Lung-T/NK_cells-Exhausted_Tfh|tumor_Lung / Location, Cell class and cell subclass

NIBAN1 CD6 DAPK2 ANKRD12

2.07e-041916843e259eba83f8159d1a1a96b98d0e867fe547c5e7
ToppCellControl-Lymphoid-T_Cytotoxic|Control / Disease state, Lineage and Cell class

NIBAN1 NOP58 CD6 PZP

2.07e-0419168403b5c5e0941c3402ab3f48cbf3da2a027d110421
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFAP61 TMEM231 DNAH6 DNAH11

2.07e-04191684e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFAP61 TMEM231 DNAH6 DNAH11

2.07e-041916849d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellCOPD-Lymphoid-T_Cytotoxic|World / Disease state, Lineage and Cell class

NIBAN1 CD6 DAPK2 PZP

2.11e-041926845bfd9f5d47511441eb2d3cc3c4d7ed330ffd0bd1
ToppCellCOPD-Lymphoid-T|World / Disease state, Lineage and Cell class

NIBAN1 NOP58 CD6 DAPK2

2.11e-04192684eb4909574fb5fc91399463523e2737095773200a
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|390C / Donor, Lineage, Cell class and subclass (all cells)

RPL31 CD6 CCR7 ANKRD12

2.11e-04192684494c5eca0f07fc761f26487a2b937c7056bbe594
ToppCellControl-Lymphoid-T|World / Disease state, Lineage and Cell class

NIBAN1 NOP58 CD6 DAPK2

2.11e-04192684253cf4d2cf88ad8c45b73779336180840bef054b
ToppCellcontrol-Lymphoid-CTL|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CD6 DAPK2 PCSK7 NMUR1

2.16e-0419368489d407a88b5956559a589425b89b3eb8dc78e1dd
ToppCellCOPD-Lymphoid-T_Cytotoxic|COPD / Disease state, Lineage and Cell class

NIBAN1 CD6 DAPK2 PZP

2.16e-0419368458e94fe2e89cdafc6974938f97a4c162061a437d
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

NIBAN1 PPP2R3A CFAP61 NPAS2

2.16e-04193684dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
Drugl-leucyl-l-tyrosine

CD6 GALNS LAP3

1.13e-0515683CID000070410
Drugbrazilin

AKAP13 PFKFB3 PFKFB4

2.01e-0518683CID000073384
DrugThioguanosine [85-31-4]; Down 200; 12.6uM; MCF7; HT_HG-U133A

CUL1 TPR PPP2R3A CLOCK RFWD3 WDR48

2.22e-051906862619_DN
Drugtriethyltin

HK1 AKAP13 PTCH1

2.39e-0519683CID005359541
DrugPenbutolol sulfate [38363-32-5]; Down 200; 5.8uM; HL60; HT_HG-U133A

SH3PXD2A SCAPER PFKFB4 TMEM231 OGG1 DOP1A

2.72e-051976862972_DN
DrugSaquinavir mesylate [149845-06-7]; Down 200; 5.2uM; PC3; HT_HG-U133A

TPR RPL31 SCAPER PCSK7 EML2 TMEM231

2.72e-051976865770_DN
DrugBoldine [476-70-0]; Up 200; 12.2uM; PC3; HT_HG-U133A

CD6 ITFG2 SH3PXD2A LRRTM4 NMUR1 CCR7

2.72e-051976864004_UP
DrugViomycin sulfate [37883-00-4]; Up 200; 5.2uM; MCF7; HT_HG-U133A

PPP2R3A SCAPER EVPL PTCH1 SEMA4G WDR48

2.72e-051976867036_UP
Drugpaclitaxel; Up 200; 0.1uM; MCF7; HG-U133A

DAPK2 EML2 EVPL AKAP13 PZP WDR48

2.80e-05198686640_UP
DrugCinnarizine [298-57-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A

EPHB4 PPP2R3A ITFG2 EML2 RPRD2 ANKRD12

2.80e-051986867174_DN
DrugVerapamyl hydrochloride [152-11-4]; Up 200; 8.2uM; MCF7; HT_HG-U133A

PPP2R3A SCAPER KCNN1 EP300 SEMA4G NPAS2

2.88e-051996861509_UP
DrugDiltiazem hydrochloride [33286-22-5]; Down 200; 8.8uM; MCF7; HT_HG-U133A

PPP2R3A ITFG2 EVPL AKAP13 CLOCK OGG1

2.88e-051996865309_DN
Drugmelarsen oxide

HK1 PFKFB3 PFKFB4

4.93e-0524683CID000030830
Drugylangene

PCSK7 SAGE1

5.25e-054682CID000019725
Diseasebasal cell carcinoma (is_marker_for)

PTCH1 OGG1

1.33e-048652DOID:2513 (is_marker_for)
DiseaseSeasonal Affective Disorder

CLOCK NPAS2

5.62e-0416652C0085159
Diseaseesophagus squamous cell carcinoma (is_marker_for)

EPHB4 FAT1 PTCH1

5.91e-0474653DOID:3748 (is_marker_for)
DiseaseAdenocarcinoma of lung (disorder)

NOP58 HK1 OGG1 EP300

1.12e-03206654C0152013
DiseaseSquamous cell carcinoma of esophagus

FAT1 FAT3 EP300

1.22e-0395653C0279626
DiseaseDrug-Induced Stevens Johnson Syndrome

CUL1 EP300

1.87e-0329652C1274933
DiseaseToxic Epidermal Necrolysis

CUL1 EP300

1.87e-0329652C0014518
DiseaseMycoplasma-Induced Stevens-Johnson Syndrome

CUL1 EP300

1.87e-0329652C3658301
DiseaseStevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum

CUL1 EP300

1.87e-0329652C3658302
DiseaseStevens-Johnson Syndrome

CUL1 EP300

2.00e-0330652C0038325

Protein segments in the cluster

PeptideGeneStartEntry
VELHTQSQDRFVYTC

EP300

1656

Q09472
VSQIAVAYHNIRDID

CDC23

266

Q9UJX2
VEVVHCRRTESQDVY

CFAP61

11

Q8NHU2
RNSEQVVQSVVHLYE

AKAP13

2516

Q12802
SIDRYVAIVQAVSAH

CCR7

151

P32248
QETVRHSITEAIVAY

DNAH11

1711

Q96DT5
TRYEVIQHVEEQSKE

ANKIB1

566

Q9P2G1
RVLCQETYIEIQTEH

DOP1A

491

Q5JWR5
VSNEQEVLRVHYRAA

ANKRD12

1926

Q6UB98
VSRTEVSNNHVLIYV

PZP

1411

P20742
VYDVRNTSSHVQELV

RFWD3

566

Q6PCD5
CTHSVVSYADVRVER

NPAS2

346

Q99743
EHYTRQVVDCQLADV

LAP3

436

P28838
EYEARCTHVVINEIT

ANO6

421

Q4KMQ2
TFYNSQRHRVTDEEV

CD6

501

P30203
RTLDYEQSRQHTIFV

FAT1

2346

Q14517
HLCTQVIEISEYRTQ

NOP58

256

Q9Y2X3
TYNICSEVQVVNTER

LRRTM4

356

Q86VH4
NVTALSVERYVAVVH

NMUR1

151

Q9HB89
EQHSVRTYEVCDVQR

EPHB4

51

P54760
VRVCERYHDKQEVTS

KCNN1

301

Q92952
VQHIIVFTATRYEDR

PCSK7

431

Q16549
IHVNRTYDEQVTSRA

PDE11A

131

Q9HCR9
ETQLQHVEDYSRILC

EVPLL

281

A8MZ36
QLHERVTQECAEYRA

EVPL

121

Q92817
SIYLNVESVCTHRER

PFKFB3

431

Q16875
VVNRVADHIQSRIVY

PFKFB4

226

Q16877
LTQTEEQLHCTVYRG

OGG1

66

O15527
REQQAVHRYVLTAVD

PCDH10

191

Q9P2E7
VTAVAYRLAEQHRQI

HK1

456

P19367
TVNHYSSVVIDRRFE

PPP2R3A

11

Q06190
YVIHRNSCEVEISRV

HNF4G

201

Q14541
YRENIVSEQAHILVD

ITGA8

626

P53708
QTYIIDHNRTVVRFQ

ITFG2

331

Q969R8
EHYNSVTRLVNIVTE

OTUD6B

276

Q8N6M0
YQEALSRITSVVQQH

GALNS

461

P34059
ISQRAVTHIYNEDIE

DNAH6

236

Q9C0G6
VITLHDVYENRTDVV

DAPK2

86

Q9UIK4
EQRRVQVYLHESTQD

CUL1

271

Q13616
QVSHTYIRVRVIEES

FAT3

3531

Q8TDW7
HIKETEQCVRSYETA

GEN1

846

Q17RS7
HVYRVLQCQEEELTQ

KCTD5

156

Q9NXV2
SVAVLYSVEEQRQRH

EML2

86

O95834
TVHSRVFQILYRNEE

FAM135B

66

Q49AJ0
QQEEHYRIETRVSSS

RPRD2

1056

Q5VT52
CEQVRLQYEHTRSVG

SEC14L4

271

Q9UDX3
RDNYVRTSEISAVHI

SCAPER

361

Q9BY12
HVSNVTVNYNVTVER

PKD1

1001

P98161
IEQIIRNYARSESHT

NKRF

606

O15226
RTYVEVVHQSVAQNS

PTCH1

401

Q13635
CTHTVVSYAEVRAER

CLOCK

371

O15516
NASYIHVQRDAVRTV

C12orf50

331

Q8NA57
QQRCIATYRVHDEGV

WDR48

241

Q8TAF3
AINEVVTREYTINIH

RPL31

16

P62899
HIIEETQVFRESQSV

SEMA4G

466

Q9NTN9
YDVTDSRITHQIVDR

PES1

366

O00541
YSVAFCNHVRTEVEQ

NIBAN1

36

Q9BZQ8
EIVQQLIDEYHAATR

TUBG1

426

P23258
TRDQYATITHNVCEE

SAGE1

336

Q9NXZ1
EVISQHLVSYRNIEE

TPR

531

P12270
VNRQHSREEKYVTVQ

SH3PXD2A

261

Q5TCZ1
THIVAAYQERNVTTV

TMEM231

211

Q9H6L2
RHSTTEVSCQNQEYL

LCMT2

481

O60294
QTAREYAVSSRHNVI

POTEH

376

Q6S545
LRYQTSQERVVDEHE

USP32

1206

Q8NFA0
QTVTLERHECYDVEN

ZNF836

71

Q6ZNA1
VSTYDDVLERHQETC

ZFP69

191

Q49AA0
VRYLEHVQAVITVNA

PCSK2

501

P16519