Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Rho GDP-dissociation inhibitor activity	ARHGDIA ARHGDIG	3.84e-05	3	72	2	GO:0005094
GeneOntologyBiologicalProcess	amyloid-beta clearance by cellular catabolic process	TREM2 LRP4 ABCA7	2.16e-06	8	71	3	GO:0150094
GeneOntologyBiologicalProcess	multi-pass transmembrane protein insertion into ER membrane	NOMO2 NOMO3 NOMO1	3.23e-06	9	71	3	GO:0160063
GeneOntologyBiologicalProcess	protein insertion into ER membrane	EMC3 NOMO2 NOMO3 NOMO1	3.78e-06	31	71	4	GO:0045048
GeneOntologyBiologicalProcess	amyloid-beta clearance	TREM2 LRP2 LRP4 ABCA7	1.07e-05	40	71	4	GO:0097242
GeneOntologyBiologicalProcess	positive regulation of engulfment of apoptotic cell	TREM2 ABCA7	1.17e-05	2	71	2	GO:1901076
GeneOntologyBiologicalProcess	protein localization to organelle	KNTC1 EMC3 BNIP3L NF1 EIF4ENIF1 NOMO2 MTOR NUP133 LRP2 MACF1 ABCA7 NOMO3 SEC13 NOMO1	1.76e-05	1091	71	14	GO:0033365
GeneOntologyBiologicalProcess	protein insertion into membrane	EMC3 NOMO2 NOMO3 NOMO1	2.63e-05	50	71	4	GO:0051205
GeneOntologyBiologicalProcess	regulation of engulfment of apoptotic cell	TREM2 ABCA7	3.50e-05	3	71	2	GO:1901074
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO2 NOMO3 NOMO1	3.24e-06	9	72	3	GO:0160064
GeneOntologyCellularComponent	nuclear pore outer ring	NUP133 NUP43 SEC13	4.62e-06	10	72	3	GO:0031080
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO2 NOMO3 NOMO1	1.39e-05	14	72	3	GO:0072379
HumanPheno	Aplasia/Hypoplasia of the corpus callosum	NF1 MTOR CYP11A1 PPFIBP1 KATNB1 TREM2 LRP2 MACF1 EML1 ADNP HCCS	4.08e-05	772	20	11	HP:0007370
HumanPheno	Abnormal corpus callosum morphology	SIN3B NF1 MTOR CYP11A1 PPFIBP1 KATNB1 TREM2 LRP2 MACF1 EML1 ADNP HCCS	4.12e-05	937	20	12	HP:0001273
HumanPheno	Lissencephaly	MTOR PPFIBP1 KATNB1 NUP133 MACF1 EML1	6.05e-05	189	20	6	HP:0001339
Domain	WD40_repeat_dom	KNTC1 EML5 WDHD1 KATNB1 APAF1 NUP43 EML1 EIF3I SEC13 DCAF12	1.74e-07	297	71	10	IPR017986
Domain	DUF2012	NOMO2 NOMO3 NOMO1	2.10e-07	4	71	3	PF09430
Domain	DUF2012	NOMO2 NOMO3 NOMO1	2.10e-07	4	71	3	IPR019008
Domain	-	EML5 WDHD1 KATNB1 APAF1 NUP133 NUP43 EML1 EIF3I SEC13 DCAF12	5.00e-07	333	71	10	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	EML5 WDHD1 KATNB1 APAF1 NUP133 NUP43 EML1 EIF3I SEC13 DCAF12	5.28e-07	335	71	10	IPR015943
Domain	WD40	EML5 WDHD1 KATNB1 APAF1 NUP43 EML1 EIF3I SEC13 DCAF12	5.81e-07	259	71	9	PF00400
Domain	WD40	EML5 WDHD1 KATNB1 APAF1 NUP43 EML1 EIF3I SEC13 DCAF12	7.72e-07	268	71	9	SM00320
Domain	WD40_repeat	EML5 WDHD1 KATNB1 APAF1 NUP43 EML1 EIF3I SEC13 DCAF12	8.74e-07	272	71	9	IPR001680
Domain	WD_REPEATS_1	EML5 WDHD1 KATNB1 APAF1 NUP43 EML1 EIF3I SEC13 DCAF12	1.05e-06	278	71	9	PS00678
Domain	WD_REPEATS_2	EML5 WDHD1 KATNB1 APAF1 NUP43 EML1 EIF3I SEC13 DCAF12	1.08e-06	279	71	9	PS50082
Domain	WD_REPEATS_REGION	EML5 WDHD1 KATNB1 APAF1 NUP43 EML1 EIF3I SEC13 DCAF12	1.08e-06	279	71	9	PS50294
Domain	Carb-bd-like_fold	NOMO2 NOMO3 NOMO1	2.91e-06	8	71	3	IPR013784
Domain	WD40_repeat_CS	EML5 WDHD1 KATNB1 APAF1 NUP43 EIF3I DCAF12	2.94e-06	164	71	7	IPR019775
Domain	CarboxyPept_regulatory_dom	NOMO2 NOMO3 NOMO1	1.47e-05	13	71	3	IPR014766
Domain	-	NOMO2 NOMO3 NOMO1	1.47e-05	13	71	3	2.60.40.1120
Domain	CarboxyPept-like_regulatory	NOMO2 NOMO3 NOMO1	3.45e-05	17	71	3	IPR008969
Domain	RhoGDI_domain	ARHGDIA ARHGDIG	4.26e-05	3	71	2	IPR024792
Domain	Rho_GDI	ARHGDIA ARHGDIG	4.26e-05	3	71	2	IPR000406
Domain	Rho_GDI	ARHGDIA ARHGDIG	4.26e-05	3	71	2	PF02115
Domain	-	ARHGDIA ARHGDIG	4.26e-05	3	71	2	2.70.50.30
Domain	HELP	EML5 EML1	2.12e-04	6	71	2	PF03451
Domain	HELP	EML5 EML1	2.12e-04	6	71	2	IPR005108
Domain	Ldl_recept_b	LRP2 LRP4	1.26e-03	14	71	2	PF00058
Domain	LDLRB	LRP2 LRP4	1.26e-03	14	71	2	PS51120
Domain	LY	LRP2 LRP4	1.45e-03	15	71	2	SM00135
Domain	LDLR_classB_rpt	LRP2 LRP4	1.45e-03	15	71	2	IPR000033
Domain	AcylCo_DH/oxidase_C	FANCG ACADL	1.65e-03	16	71	2	IPR009075
Domain	Apc4_WD40_dom	EML5 WDHD1	2.59e-03	20	71	2	IPR024977
Domain	ANAPC4_WD40	EML5 WDHD1	2.59e-03	20	71	2	PF12894
Domain	cEGF	LRP2 LRP4	4.37e-03	26	71	2	IPR026823
Domain	cEGF	LRP2 LRP4	4.37e-03	26	71	2	PF12662
Pathway	REACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION	NUP133 NUP43 SEC13	1.13e-04	24	56	3	MM15658
Pathway	REACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION	NUP133 NUP43 SEC13	1.62e-04	27	56	3	M29807
Pathway	REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN	NUP133 NUP43 SEC13	2.71e-04	32	56	3	M29579
Pathway	REACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS	NUP133 NUP43 SEC13	2.98e-04	33	56	3	M27016
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_CYTOCHROME_C_RELEASE	BNIP3L PRELID3A	3.21e-04	7	56	2	MM15333
Pathway	REACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN	NUP133 NUP43 SEC13	3.26e-04	34	56	3	M27041
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	NUP133 NUP43 SEC13	3.55e-04	35	56	3	M27320
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	NUP133 NUP43 SEC13	3.86e-04	36	56	3	M26974
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	NUP133 NUP43 SEC13	3.86e-04	36	56	3	M27245
Pathway	REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS	NUP133 NUP43 SEC13	4.19e-04	37	56	3	M1029
Pathway	REACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS	NUP133 NUP43 SEC13	4.19e-04	37	56	3	M27038
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS	MTOR NUP133 NUP43 SEC13	4.81e-04	92	56	4	MM14951
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	NUP133 NUP43 SEC13	4.90e-04	39	56	3	M27238
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	NUP133 NUP43 SEC13	5.29e-04	40	56	3	MM14945
Pathway	REACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS	NUP133 NUP43 SEC13	5.69e-04	41	56	3	M29574
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	NUP133 NUP43 SEC13	5.69e-04	41	56	3	MM15200
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	NUP133 NUP43 SEC13	6.11e-04	42	56	3	MM15039
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	NUP133 NUP43 SEC13	6.55e-04	43	56	3	MM14609
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	NUP133 NUP43 SEC13	6.55e-04	43	56	3	M26975
Pathway	REACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES	KNTC1 NUP133 NUP43 SEC13	6.60e-04	100	56	4	MM14561
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS	MTOR NUP133 NUP43 SEC13	6.85e-04	101	56	4	M27253
Pathway	REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS	NUP133 NUP43 SEC13	7.01e-04	44	56	3	M109
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_DEATH_GENES	BNIP3L PRELID3A APAF1	7.01e-04	44	56	3	M27499
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	NUP133 NUP43 SEC13	7.99e-04	46	56	3	M27397
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	NUP133 NUP43 SEC13	8.51e-04	47	56	3	M27395
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	NUP133 NUP43 SEC13	8.51e-04	47	56	3	MM14939
Pathway	REACTOME_GENE_SILENCING_BY_RNA	NUP133 NUP43 SEC13	9.61e-04	49	56	3	MM14837
Pathway	REACTOME_MITOTIC_SPINDLE_CHECKPOINT	KNTC1 NUP133 NUP43 SEC13	9.76e-04	111	56	4	M27673
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	NUP133 NUP43 SEC13	1.02e-03	50	56	3	MM14610
Pathway	REACTOME_MITOTIC_SPINDLE_CHECKPOINT	KNTC1 NUP133 NUP43 SEC13	1.19e-03	117	56	4	MM15387
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	NUP133 NUP43 SEC13	1.21e-03	53	56	3	M27212
Pathway	REACTOME_SNRNP_ASSEMBLY	NUP133 NUP43 SEC13	1.28e-03	54	56	3	M29594
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	NUP133 NUP43 SEC13	1.35e-03	55	56	3	MM14917
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	NUP133 NUP43 SEC13	1.57e-03	58	56	3	MM15149
Pathway	REACTOME_SNRNP_ASSEMBLY	NUP133 NUP43 SEC13	1.57e-03	58	56	3	MM14736
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_DEATH_GENES	BNIP3L PRELID3A	1.57e-03	15	56	2	MM15227
Pathway	REACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION	KNTC1 NUP133 NUP43 SEC13	1.61e-03	127	56	4	M27181
Pathway	REACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS	NUP133 NUP43 SEC13	1.65e-03	59	56	3	M27606
Pathway	REACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION	KNTC1 NUP133 NUP43 SEC13	1.70e-03	129	56	4	MM14894
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	KNTC1 ARHGDIA ARHGDIG EMC3 NUP133 NUP43 FNBP1L MPP7 SEC13	1.97e-03	720	56	9	M41838
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	NUP133 NUP43 SEC13	2.18e-03	65	56	3	MM15147
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_FORMINS	KNTC1 NUP133 NUP43 SEC13	2.29e-03	140	56	4	M27550
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_FORMINS	KNTC1 NUP133 NUP43 SEC13	2.35e-03	141	56	4	MM15266
Pathway	REACTOME_NUCLEAR_ENVELOPE_NE_REASSEMBLY	NUP133 NUP43 SEC13	2.48e-03	68	56	3	MM14921
Pathway	PID_P75_NTR_PATHWAY	ARHGDIA APAF1 PRDM4	2.48e-03	68	56	3	M153
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	NUP133 NUP43 SEC13	2.80e-03	71	56	3	M27394
Pathway	REACTOME_RHOG_GTPASE_CYCLE	ARHGDIA ARHGDIG MPP7	2.80e-03	71	56	3	MM15604
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_CYTOCHROME_C_RELEASE	BNIP3L PRELID3A	2.81e-03	20	56	2	M27628
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO2 NOMO3 NOMO1	8.51e-09	3	72	3	36011023
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO2 NOMO3 NOMO1	8.51e-09	3	72	3	25576386
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO2 NOMO3 NOMO1	3.40e-08	4	72	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO2 NOMO3 NOMO1	3.40e-08	4	72	3	9267806
Pubmed	Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6.	SIN3B EMC3 NOMO2 NOMO3 NOMO1	2.11e-07	63	72	5	31266804
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO2 NOMO3 NOMO1	4.73e-07	8	72	3	15257293
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO2 NOMO3 NOMO1	7.08e-07	9	72	3	36261522
Pubmed	Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex.	NUP133 NUP43 SEC13	7.08e-07	9	72	3	17360435
Pubmed	The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis.	NUP133 NUP43 SEC13	1.01e-06	10	72	3	15146057
Pubmed	The discovery of a Werner Helicase Interacting Protein (WHIP) association with the nuclear pore complex.	NUP133 NUP43 SEC13	1.01e-06	10	72	3	20676042
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO2 NOMO3 NOMO1	1.39e-06	11	72	3	32820719
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	USP34 CLGN NF1 NOMO2 PPFIBP1 COX5B NUP133 EIF3I ADNP NOMO3 NOMO1	2.61e-06	910	72	11	36736316
Pubmed	Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.	NOMO2 PPFIBP1 KAZN NOMO3 NOMO1	3.41e-06	110	72	5	27889896
Pubmed	Characterization of Rho-GDIgamma and Rho-GDIalpha mRNA in the developing and mature brain with an analysis of mice with targeted deletions of Rho-GDIgamma.	ARHGDIA ARHGDIG	4.23e-06	2	72	2	16054116
Pubmed	Hyperactivation of mTOR critically regulates abnormal osteoclastogenesis in neurofibromatosis Type 1.	NF1 MTOR	4.23e-06	2	72	2	21748792
Pubmed	Carcinoma-associated eIF3i overexpression facilitates mTOR-dependent growth transformation.	MTOR EIF3I	4.23e-06	2	72	2	16929481
Pubmed	Insulin inhibition of apolipoprotein B mRNA translation is mediated via the PI-3 kinase/mTOR signaling cascade but does not involve internal ribosomal entry site (IRES) initiation.	MTOR APOB	4.23e-06	2	72	2	17698027
Pubmed	Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors.	ARHGDIA ARHGDIG	4.23e-06	2	72	2	15513926
Pubmed	Truncated apo B-70.5-containing lipoproteins bind to megalin but not the LDL receptor.	LRP2 APOB	4.23e-06	2	72	2	10330424
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 ARHGDIA NF1 MTOR NUP133 MACF1 EIF3I ADNP SEC13	8.15e-06	653	72	9	22586326
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	DDX50 PPFIBP1 APAF1 ARID5B MACF1 APOB MGAM2 SEC13	8.70e-06	496	72	8	31343991
Pubmed	C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.	NF1 APOB	1.27e-05	3	72	2	11727199
Pubmed	Apaf-1 deficiency and neural tube closure defects are found in fog mice.	APAF1 ABCA7	1.27e-05	3	72	2	11504943
Pubmed	Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls.	TREM2 ABCA7	1.27e-05	3	72	2	28789839
Pubmed	MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1.	NF1 MTOR	2.53e-05	4	72	2	24509877
Pubmed	p53 and NF 1 loss plays distinct but complementary roles in glioma initiation and progression.	NF1 MTOR	2.53e-05	4	72	2	29392777
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	ARHGDIA EIF4ENIF1 NOMO2 AHSA1 NOMO3 SEC13 NOMO1	2.88e-05	425	72	7	24999758
Pubmed	The functional interactome landscape of the human histone deacetylase family.	SIN3B ARID5B NUP133 TFIP11 ADNP BRMS1	3.08e-05	289	72	6	23752268
Pubmed	Integrated structural analysis of the human nuclear pore complex scaffold.	NUP133 NUP43 SEC13	3.32e-05	30	72	3	24315095
Pubmed	Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.	SIN3B DDX3Y BRMS1	3.32e-05	30	72	3	16449650
Pubmed	The Structure Inventory of the Nuclear Pore Complex.	NUP133 NUP43 SEC13	3.32e-05	30	72	3	27016207
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	KNTC1 ARHGDIA NF1 DDX50 MTOR NUP133 APOB EIF3I ADNP AHSA1 MGAM2 NOMO1	3.37e-05	1425	72	12	30948266
Pubmed	Hepatic lipase maturation: a partial proteome of interacting factors.	NOMO2 NOMO3 NOMO1	3.67e-05	31	72	3	19136429
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	KNTC1 USP34 ARHGDIA EMC3 CLGN DDX50 MTOR PPFIBP1 NUP133 NUP43 LRP4 EIF3I	3.73e-05	1440	72	12	30833792
Pubmed	The sequence and analysis of duplication-rich human chromosome 16.	ARHGDIG NOMO2 NOMO3 NOMO1	3.77e-05	90	72	4	15616553
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	EMC3 NOMO2 NUP133 DDX3Y COLGALT2 AHSA1 NOMO3 NOMO1	3.95e-05	613	72	8	22268729
Pubmed	Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb.	BNIP3L MTOR	4.21e-05	5	72	2	17928295
Pubmed	Transcriptional repression by leukaemia-associated ETO family members can be independent of oligomerization and coexpressed hSIN3B and N-CoR.	SIN3B CBFA2T2	4.21e-05	5	72	2	18586123
Pubmed	Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.	LRP2 LRP4	4.21e-05	5	72	2	19047013
Pubmed	An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.	NOMO2 NOMO3 NOMO1	4.44e-05	33	72	3	30783098
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SIN3B EIF4ENIF1 DDX50 ZNF277 PPFIBP1 COX5B MACF1 TFIP11 EIF3I MPP7 SEC13 NOMO1	5.43e-05	1497	72	12	31527615
Pubmed	The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.	ARHGDIA ARHGDIG	6.31e-05	6	72	2	11809807
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	CLGN NF1 MTOR NUP133 NUP43 RHBDD3 EIF3I NOMO1	6.42e-05	657	72	8	36180527
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	NUP133 NUP43 SEC13	6.81e-05	38	72	3	12791264
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	USP34 EML5 DDX50 WDHD1 ARID5B LRP2 MACF1 DDX3Y TFIP11 APOB	7.72e-05	1084	72	10	11544199
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	ARHGDIA CLGN NF1 EML5 EIF4ENIF1 SERINC1 MTOR PPFIBP1 NUP133 HCCS NOMO1	8.21e-05	1321	72	11	27173435
Pubmed	A protein interaction framework for human mRNA degradation.	NOMO2 COX5B KATNB1 EIF3I NOMO3 NOMO1	8.48e-05	347	72	6	15231747
Pubmed	The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice.	NF1 MTOR	8.82e-05	7	72	2	16906226
Pubmed	C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47.	SERINC1 APOB	8.82e-05	7	72	2	24916387
Pubmed	Centrin 2 localizes to the vertebrate nuclear pore and plays a role in mRNA and protein export.	NUP133 NUP43	8.82e-05	7	72	2	18172010
Pubmed	Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.	NF1 MTOR	8.82e-05	7	72	2	21896734
Pubmed	RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG.	ARHGDIA ARHGDIG	8.82e-05	7	72	2	8939998
Pubmed	Systematic Protein-Protein Interaction Analysis Reveals Intersubcomplex Contacts in the Nuclear Pore Complex.	NUP133 SEC13	1.17e-04	8	72	2	27194810
Pubmed	mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin.	MTOR EIF3I	1.17e-04	8	72	2	16541103
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ARHGDIA SIN3B DDX50 NUP133 MACF1 TFIP11 EIF3I ADNP AHSA1	1.31e-04	934	72	9	33916271
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	PPFIBP1 ARID5B NUP43 FNBP1L ABCA7 MPP7	1.35e-04	378	72	6	34315543
Pubmed	Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.	NF1 MTOR	1.51e-04	9	72	2	27340174
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	ARHGDIA EMC3 CLGN NOMO2 PPFIBP1 NUP133 RHBDD3 NOMO3 NOMO1	1.51e-04	952	72	9	38569033
Pubmed	Human transcription factor protein interaction networks.	SIN3B EIF4ENIF1 DDX50 COX5B ARID5B LRP2 TFIP11 EIF3I ADNP SEC13 BRMS1	1.64e-04	1429	72	11	35140242
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	USP34 ABCC3 EMC3 CLGN NF1 NOMO2 LRP4 ABCA7 NOMO1 DCAF12	1.78e-04	1201	72	10	35696571
Pubmed	BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy.	BNIP3L APAF1	1.88e-04	10	72	2	17576813
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	KNTC1 USP34 NOMO2 ARID5B MACF1 FNBP1L EIF3I	2.17e-04	588	72	7	38580884
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	SIN3B EIF4ENIF1 NUP133 MACF1 KCNB2	2.20e-04	263	72	5	34702444
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP2 LRP4	2.30e-04	11	72	2	24639464
Pubmed	Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.	SIN3B BRMS1	2.30e-04	11	72	2	14581478
Pubmed	CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.	ARHGDIG PPFIBP1 DYNLT2	2.30e-04	57	72	3	36849460
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	USP34 SIN3B EIF4ENIF1 ARID5B LRP2 ADNP	2.33e-04	418	72	6	34709266
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP34 NF1 WDHD1 MTOR	2.52e-04	147	72	4	29576527
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	NOMO2 MTOR COX5B NUP133 AHSA1 NOMO3 NOMO1	2.61e-04	606	72	7	36538041
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	EIF4ENIF1 ZNF277 CBFA2T2 LRP2 KAZN NOMO3 NOMO1	2.66e-04	608	72	7	16713569
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	BNIP3L EIF4ENIF1 CBFA2T2 INAVA ADNP PRDM4	2.71e-04	430	72	6	35044719
Pubmed	A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland.	LRP2 APOB	2.75e-04	12	72	2	8631881
Pubmed	TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.	TREM2 APOB	2.75e-04	12	72	2	27477018
Pubmed	Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.	DDX3Y NOMO3 NOMO1	2.95e-04	62	72	3	15862967
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP34 NOMO2 PPFIBP1 ARID5B LRP2 NUP43 LRP4 MACF1 TFIP11 PRDM4	3.06e-04	1285	72	10	35914814
Pubmed	Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.	DDX50 PPFIBP1 MACF1 MPP7	3.48e-04	160	72	4	31678930
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ABCC3 NF1 WDHD1 COX5B ARID5B COLGALT2 NOMO3	3.55e-04	638	72	7	31182584
Pubmed	The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions.	NUP133 NUP43	3.78e-04	14	72	2	17363900
Pubmed	Maternal diabetes causes coordinated down-regulation of genes involved with lipid metabolism in the murine fetal heart.	ACADL APOB	3.78e-04	14	72	2	18502258
Pubmed	Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis.	NUP133 EIF3I SEC13	4.58e-04	72	72	3	33106477
Pubmed	Large-scale analysis of the human ubiquitin-related proteome.	EMC3 COX5B NUP133 NUP43 RHBDD3	4.89e-04	313	72	5	16196087
Pubmed	SZT2 dictates GATOR control of mTORC1 signalling.	MTOR SEC13	4.98e-04	16	72	2	28199315
Pubmed	Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.	EMC3 COX5B NUP133 NUP43	5.43e-04	180	72	4	21139048
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KNTC1 SIN3B PPFIBP1 MACF1 KAZN DCAF12	5.58e-04	493	72	6	15368895
Pubmed	Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.	NF1 MTOR	6.33e-04	18	72	2	33323119
Pubmed	Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.	SIN3B BRMS1	7.06e-04	19	72	2	22984288
Pubmed	Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.	SIN3B BRMS1	7.06e-04	19	72	2	28554894
Pubmed	The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.	SIN3B WDHD1 ADNP	7.19e-04	84	72	3	26299517
Pubmed	KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.	MTOR SEC13	7.84e-04	20	72	2	28199306
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	KNTC1 USP34 WDHD1 MTOR NUP133 NUP43 MACF1 EIF3I AHSA1 SEC13	8.05e-04	1455	72	10	22863883
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	KNTC1 USP34 CLGN EIF4ENIF1 WDHD1 NOMO2 TFIP11	8.07e-04	733	72	7	34672954
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	ARHGDIA COX5B NUP133 ADNP AHSA1 NOMO3	8.45e-04	534	72	6	35032548
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP2 LRP4	8.65e-04	21	72	2	21337463
Pubmed	Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.	CYP11A1 LRP2	8.65e-04	21	72	2	9616220
Pubmed	A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.	USP34 COX5B CTAGE1 APOB	8.82e-04	205	72	4	12040188
Pubmed	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	BNIP3L ACADL CYP11A1 COX5B HCCS NT5M	9.12e-04	542	72	6	14651853
Pubmed	Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.	NOMO2 NOMO3 NOMO1	9.36e-04	92	72	3	10493829
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	EMC3 NOMO2 PPFIBP1 COX5B APAF1 NUP133 MACF1 TFIP11 MPP7 NOMO1	9.50e-04	1487	72	10	33957083
Pubmed	SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.	SIN3B BRMS1	1.04e-03	23	72	2	9651585
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	NF1 NUP133 TFIP11 KAZN EML1 NOMO1	1.08e-03	560	72	6	21653829
Interaction	TRPC6 interactions	SIN3B EMC3 NOMO2 NOMO3 NOMO1	1.11e-05	82	72	5	int:TRPC6
GeneFamily	WD repeat domain containing	EML5 WDHD1 KATNB1 APAF1 NUP43 EML1 EIF3I SEC13 DCAF12	2.07e-08	262	47	9	362
GeneFamily	Nucleoporins	NUP133 NUP43 SEC13	7.75e-05	32	47	3	1051
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	NUP133 DDX3Y LY75	3.14e-04	51	47	3	870
GeneFamily	Low density lipoprotein receptors	LRP2 LRP4	5.07e-04	13	47	2	634
GeneFamily	DEAD-box helicases	DDX50 DDX3Y	5.33e-03	42	47	2	499
Coexpression	GSE25087_TREG_VS_TCONV_FETUS_UP	CLGN NF1 DDX50 SERINC1 LRP4 LY75	1.78e-05	198	72	6	M4647
Coexpression	ZENG_GU_ICB_CONTROL_METAGENE_21_PRECICTIVE_ICB_RESISTANCE	PRELID3A NOMO2 LRP2 EIF3I NOMO3 NOMO1	2.22e-05	206	72	6	MM17087
Drug	Nitrofurantoin [67-20-9]; Down 200; 16.8uM; HL60; HT_HG-U133A	EIF4ENIF1 WDHD1 MTOR CBFA2T2 MACF1 NT5M BRMS1	2.72e-06	197	71	7	2341_DN
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	CTAGE1 LRP4 MACF1 APOB	2.41e-04	127	70	4	EFO_0008595, EFO_0020947
Disease	brain infarction, neuritic plaque measurement, Lewy body dementia, cerebral amyloid angiopathy, neurofibrillary tangles measurement	KAZN KCNB2	1.24e-03	22	70	2	EFO_0004277, EFO_0006790, EFO_0006792, EFO_0006797, EFO_0006798
Disease	nephrosis (biomarker_via_orthology)	CYP11A1 LRP2	1.24e-03	22	70	2	DOID:2527 (biomarker_via_orthology)
Disease	middle cerebral artery infarction (biomarker_via_orthology)	BNIP3L MTOR APAF1	1.42e-03	93	70	3	DOID:3525 (biomarker_via_orthology)
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	LRP4 MACF1 APOB	1.91e-03	103	70	3	EFO_0008595, EFO_0020944
Disease	Toxic Encephalitis	CRISPLD2 MTOR	2.16e-03	29	70	2	C0154659
Disease	Neurotoxicity Syndromes	CRISPLD2 MTOR	2.16e-03	29	70	2	C0235032
Disease	Encephalopathy, Toxic	CRISPLD2 MTOR	2.16e-03	29	70	2	C0149504
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	ARHGDIA NUP133	2.31e-03	30	70	2	C1868672

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASLWLWKSDIASHFS	ADNP	791	Q9H2P0
ILDDVWDSWVLKAFD	APAF1	241	O14727
EKKAHDNWSAAWTAE	CTAGE1	426	Q96RT6
HSEWEKAGEVSREVW	ACADL	76	P28330
HWTERDASNWSTDKL	AHSA1	26	O95433
EVKTFLALAHKWWDE	COQ3	96	Q9NZJ6
AWKEILKWEALHAAE	HCCS	161	P53701
WAHSLDAQDSLKIWF	ABCA7	1461	Q8IZY2
LWHWDASTDVPEKSS	NUP43	286	Q8NFH3
DADIKVSFWQWAHED	MMP26	146	Q9NRE1
HEDWCWKNKSLEVEV	NOMO3	561	P69849
SEEDIWWALELSHLH	ABCC3	1391	O15438
ARAWAWTELLDAVHA	NIBAN3	296	Q86XR2
KWELDDSSEKHAYSW	NUP133	296	Q8WUM0
LEHWQGLEAEDWTAA	INKA1	161	Q96EL1
HEDWCWKNKSLEVEV	NOMO2	561	Q5JPE7
AELDHHWVAKAWLND	KAZN	521	Q674X7
AAHWLGDNAATWDDL	MGAM2	571	Q2M2H8
HGKLDFNWVTRWLDD	PPFIBP1	716	Q86W92
WTEAQKIWEDGSSDH	KIAA1109	4691	Q2LD37
WLASAADDHTVKLWD	KATNB1	161	Q9BVA0
EREWADEWKHLDHAL	CBFA2T2	341	O43439
DNTSVVWFWLHKGEA	COX5B	96	P10606
TWDDELEKSAAAWAS	CRISPLD2	81	Q9H0B8
SQDDATWWQAKHEAD	MPP7	266	Q5T2T1
HEDWCWKNKSLEVEV	NOMO1	561	Q15155
AWKKLIDWLEDAESH	MACF1	2686	O94854
DSSAMLWWKCEHHSL	LY75	101	O60449
AEKTDELGLASSWHW	KNTC1	656	P50748
ELGLASSWHWISLKD	KNTC1	661	P50748
LYWADWDTHAKIERA	LRP2	2521	P98164
WWRLEAQTKGSHEDA	FANCG	571	O15287
FHEAWKKLIDWLEDA	MACF1	6556	Q9UPN3
SDWWTLAAKNLTDFA	APOB	2551	P04114
SADDNHLSPSRWKWA	KCNB2	481	Q92953
KALHWTTSDWARHSD	BNIP5	46	P0C671
ELWDQFDSLDKHTQW	FNBP1L	6	Q5T0N5
FTDDDKTDHLSWEWN	ARHGDIA	181	P52565
LFTDDDRTHHLSWEW	ARHGDIG	201	Q99819
DGHKDWIFSIAWISD	DCAF12	181	Q5T6F0
HTGAVWCVDADWDTK	EIF3I	51	Q13347
WCVDADWDTKHVLTG	EIF3I	56	Q13347
VEALKKSADWVSDWS	BNIP3L	131	O60238
SERLQAEWHDSDWIL	DDX50	641	Q9BQ39
AEWHDSDWILSVPAK	DDX50	646	Q9BQ39
KTWKDHVAAWDVIFS	CYP11A1	261	P05108
DDSNDHVLSVWDWQK	EML1	346	O00423
GIDDSHTVVLWDWKK	EML5	791	Q05BV3
EWEALELTDHQWALD	EMC3	221	Q9P0I2
GHSRWCDKSVEDDWS	DDX3Y	121	O15523
ETVATDWDRTHAWKS	COLGALT2	581	Q8IYK4
SKAAVSEELKWWHER	INAVA	581	Q3KP66
EVAEWTDKAVNHIWK	PRDM4	451	Q9UKN5
QATWYEKLHEWEDAL	MTOR	1446	P42345
LHSWADDWKAILDSK	NT5M	211	Q9NPB1
QKLEAHSDWVRDVAW	SEC13	206	P55735
LWTNDHALAWHLSDD	SUSD2	266	Q9UGT4
GWAAIEWIIEHSESA	PRELID3A	156	Q96N28
KELDHWTLLQGSWTD	SIN3B	421	O75182
AVDSSKWAWDSGLVL	SLC9A5	351	Q14940
LIDFAHSWNESWVEK	SERINC1	171	Q9NRX5
LSSEWWDDKLHARGS	BRMS1	176	Q9HCU9
WDDKLHARGSSRSWD	BRMS1	181	Q9HCU9
DSDGVWDPEKWHASL	EIF4ENIF1	56	Q9NRA8
LEDLVKWVHSDFSKW	ARID5B	106	Q14865
SEKEVADHWAADGWR	CLGN	431	O14967
VASPDLWSHWEDSAL	RHBDD3	241	Q9Y3P4
LHCLHFSSWDSSKEW	WDHD1	511	O75717
AGNTEAWEDTHAKWE	NF1	771	P21359
AWEDTHAKWEQATKL	NF1	776	P21359
KILAASALWAAAWHG	TREM2	186	Q9NZC2
ADAHWWSERTHKNLS	RHCG	36	Q9UBD6
WLGHLLKAWFSETDS	ZNF852	526	Q6ZMS4
DWSDWEEHPASAVCL	ZNF277	291	Q9NRM2
FDVSSELLEWIWHDN	USP34	2251	Q70CQ2
DLSADAFHRLIWEVW	TFIP11	471	Q9UBB9
DWEDSEDWLSAHSLK	VWA3A	86	A6NCI4
IAWDSWVAAKHEAES	DYNLT2	171	Q8IZS6
LAVDWVHDKLYWTDS	LRP4	516	O75096