Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpotassium:chloride symporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

2.41e-089764GO:0015379
GeneOntologyMolecularFunctionammonium channel activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

9.37e-0812764GO:0008519
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.62e-0623764GO:0015377
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

2.72e-0626764GO:0015296
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC6A5 SLC12A7 SLC12A5

9.11e-05119765GO:0015294
GeneOntologyMolecularFunctionsymporter activity

SLC12A6 SLC12A4 SLC6A5 SLC12A7 SLC12A5

2.69e-04150765GO:0015293
GeneOntologyMolecularFunctionimmune receptor activity

IL12RB1 IL13RA1 IL20RB IL27RA LILRA4

4.17e-04165765GO:0140375
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

SLC12A6 SLC12A4 LRRC26 SLC12A7 SLC12A5

4.41e-04167765GO:0015079
GeneOntologyMolecularFunctioncytokine receptor activity

IL12RB1 IL13RA1 IL20RB IL27RA

5.14e-0497764GO:0004896
GeneOntologyMolecularFunctionguanylate kinase activity

MPP1 CASK

7.69e-0411762GO:0004385
GeneOntologyMolecularFunctioncytidine deaminase activity

APOBEC3D APOBEC3B

1.09e-0313762GO:0004126
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.33e-03125764GO:0015108
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

IL12RB1 IL13RA1 TNFRSF25 NPBWR2 OR10A2 GLP1R IL20RB GPR55 PTGER3 VN1R1 ADCYAP1R1 IL27RA LILRA4

1.67e-0313537613GO:0004888
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC12A6 SLC12A4 LRRC26 SLC6A5 SLC12A7 RYR3 SLC12A5

1.95e-03465767GO:0046873
GeneOntologyMolecularFunctionpeptide receptor activity

NPBWR2 GLP1R GUCY2D ADCYAP1R1

2.01e-03140764GO:0001653
GeneOntologyMolecularFunctionadenylate cyclase activity

GUCY2D ADCY1

2.10e-0318762GO:0004016
GeneOntologyBiologicalProcessammonium transmembrane transport

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.06e-0713744GO:0072488
GeneOntologyBiologicalProcessammonium import across plasma membrane

SLC12A6 SLC12A4 SLC12A7

1.77e-074743GO:0140157
GeneOntologyBiologicalProcesschloride ion homeostasis

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.82e-0625744GO:0055064
GeneOntologyBiologicalProcessmonoatomic anion homeostasis

SLC12A6 SLC12A4 SLC12A7 SLC12A5

2.93e-0628744GO:0055081
GeneOntologyBiologicalProcesspotassium ion homeostasis

SLC12A6 SLC12A4 SLC12A7 SLC12A5

9.22e-0637744GO:0055075
GeneOntologyBiologicalProcessmetal ion transport

SLC12A6 SLC35G1 SLC12A4 GLP1R LRRC26 SLC6A5 UBR3 SLC12A7 PTGER3 HEPH ADCYAP1R1 RYR3 SLC12A5 CASK

1.09e-0510007414GO:0030001
GeneOntologyBiologicalProcesscell volume homeostasis

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.54e-0542744GO:0006884
GeneOntologyBiologicalProcesspotassium ion import across plasma membrane

SLC12A6 SLC12A4 SLC12A7 SLC12A5

3.36e-0551744GO:1990573
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC12A6 SLC35G1 SLC12A4 GLP1R LRRC26 SLC6A5 UBR3 SLC12A7 PTGER3 HEPH ADCYAP1R1 RYR3 SLC12A5 CASK

5.45e-0511577414GO:0006812
GeneOntologyBiologicalProcessproteasomal ubiquitin-independent protein catabolic process

PSME4 ENC1

7.58e-054742GO:0010499
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC12A6 SLC35G1 SLC12A4 GLP1R LRRC26 SLC6A5 UBR3 SLC12A7 PTGER3 ADCYAP1R1 RYR3 SLC12A5

1.01e-049227412GO:0098662
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC12A6 SLC35G1 SLC12A4 GLP1R LRRC26 SLC6A5 UBR3 SLC12A7 PTGER3 ADCYAP1R1 RYR3 SLC12A5

1.23e-049427412GO:0098655
GeneOntologyBiologicalProcesscAMP-mediated signaling

GLP1R PTGER3 ADCY1 ADCYAP1R1

1.61e-0476744GO:0019933
GeneOntologyBiologicalProcesspotassium ion transmembrane transport

SLC12A6 SLC12A4 LRRC26 SLC12A7 PTGER3 SLC12A5

1.86e-04232746GO:0071805
GeneOntologyBiologicalProcessclearance of foreign intracellular DNA

APOBEC3D APOBEC3B

1.89e-046742GO:0044355
GeneOntologyBiologicalProcessclearance of foreign intracellular nucleic acids

APOBEC3D APOBEC3B

1.89e-046742GO:0099046
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC12A6 SLC35G1 SLC12A4 GLP1R LRRC26 SLC6A5 UBR3 SLC12A7 PTGER3 ADCYAP1R1 RYR3 SLC12A5

2.51e-0410177412GO:0098660
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC12A6 SLC35G1 SLC12A4 GLP1R LRRC26 SLC6A5 UBR3 SLC12A7 PTGER3 HEPH ADCYAP1R1 RYR3 SLC12A5 CASK

3.32e-0413747414GO:0006811
GeneOntologyBiologicalProcesstype II interferon production

IL12RB1 VTCN1 IRF8 IL20RB IL27RA

3.55e-04169745GO:0032609
GeneOntologyBiologicalProcesslearning or memory

AAAS GLP1R BACE1 EN1 ADCY1 PTGS1 SLC12A5

3.80e-04373747GO:0007611
GeneOntologyBiologicalProcesspotassium ion transport

SLC12A6 SLC12A4 LRRC26 SLC12A7 PTGER3 SLC12A5

4.35e-04272746GO:0006813
GeneOntologyBiologicalProcesschemical homeostasis

SLC12A6 SLC35G1 MLXIPL TLCD1 SLC12A4 GLP1R INSIG1 ACSM1 PKHD1 SLC12A7 SLC66A1 RYR3 SLC12A5

4.56e-0412497413GO:0048878
GeneOntologyBiologicalProcessregulation of G protein-coupled receptor signaling pathway

GPRASP1 GUCY2D PTGER3 USP20 USP33

4.86e-04181745GO:0008277
GeneOntologyBiologicalProcessDNA cytosine deamination

APOBEC3D APOBEC3B

5.61e-0410742GO:0070383
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC12A6 SLC35G1 SLC12A4 GLP1R LRRC26 SLC6A5 UBR3 SLC12A7 PTGER3 ADCYAP1R1 RYR3 SLC12A5

5.76e-0411157412GO:0034220
DomainKCL_cotranspt

SLC12A6 SLC12A4 SLC12A7 SLC12A5

2.53e-104764IPR000076
DomainSLC12A_fam

SLC12A6 SLC12A4 SLC12A7 SLC12A5

8.78e-097764IPR004842
DomainSLC12_C

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.75e-088764IPR018491
DomainSLC12

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.75e-088764PF03522
DomainAA-permease/SLC12A_dom

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.75e-0622764IPR004841
DomainAA_permease

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.75e-0622764PF00324
DomainKCC1

SLC12A6 SLC12A4

1.63e-052762IPR000622
DomainDUSP

USP20 USP33

2.43e-046762SM00695
DomainDUSP

USP20 USP33

2.43e-046762PF06337
Domain-

USP20 USP33

3.39e-0477623.30.2230.10
DomainDUSP

USP20 USP33

3.39e-047762PS51283
DomainPept_C19_DUSP

USP20 USP33

3.39e-047762IPR006615
DomainHEMATOPO_REC_L_F2

IL12RB1 IL27RA

4.50e-048762PS01353
DomainZnF_UBP

USP20 USP33

8.78e-0411762SM00290
DomainAPOBEC_N

APOBEC3D APOBEC3B

1.05e-0312762PF08210
DomainAPOBEC_N

APOBEC3D APOBEC3B

1.05e-0312762IPR013158
DomainZnf_UBP

USP20 USP33

1.44e-0314762IPR001607
DomainAPOBEC/CMP_deaminase_Zn-bd

APOBEC3D APOBEC3B

1.44e-0314762IPR016192
Domainzf-UBP

USP20 USP33

1.44e-0314762PF02148
DomainZF_UBP

USP20 USP33

1.44e-0314762PS50271
Domain-

IL12RB1 IL13RA1 CD33 VTCN1 PKHD1 IL20RB SIGLECL1 IL27RA LILRA4

1.45e-036637692.60.40.10
DomainGuanylate_kinase_CS

MPP1 CASK

1.89e-0316762IPR020590
DomainA/G_cyclase_CS

GUCY2D ADCY1

2.14e-0317762IPR018297
DomainCytidine_deaminase-like

APOBEC3D APOBEC3B

2.14e-0317762IPR016193
DomainCYT_DCMP_DEAMINASES_1

APOBEC3D APOBEC3B

2.14e-0317762PS00903
DomainCMP_dCMP_Zn-bd

APOBEC3D APOBEC3B

2.14e-0317762IPR002125
DomainTSP_1

SEMA5B ADAMTS5 SSPOP

2.16e-0363763PF00090
DomainIg-like_fold

IL12RB1 IL13RA1 CD33 VTCN1 PKHD1 IL20RB SIGLECL1 IL27RA LILRA4

2.22e-03706769IPR013783
DomainTSP1

SEMA5B ADAMTS5 SSPOP

2.36e-0365763SM00209
DomainTSP1_rpt

SEMA5B ADAMTS5 SSPOP

2.36e-0365763IPR000884
DomainTSP1

SEMA5B ADAMTS5 SSPOP

2.36e-0365763PS50092
DomainNucleotide_cyclase

GUCY2D ADCY1

2.40e-0318762IPR029787
Domain-

GUCY2D ADCY1

2.40e-03187623.30.70.1230
DomainGUANYLATE_CYCLASE_1

GUCY2D ADCY1

2.67e-0319762PS00452
DomainGuanylate_cyc

GUCY2D ADCY1

2.67e-0319762PF00211
DomainGUANYLATE_CYCLASE_2

GUCY2D ADCY1

2.67e-0319762PS50125
DomainA/G_cyclase

GUCY2D ADCY1

2.67e-0319762IPR001054
DomainCYCc

GUCY2D ADCY1

2.67e-0319762SM00044
DomainGUANYLATE_KINASE_2

MPP1 CASK

3.91e-0323762PS50052
DomainGUANYLATE_KINASE_1

MPP1 CASK

3.91e-0323762PS00856
DomainHormR

GLP1R ADCYAP1R1

4.61e-0325762SM00008
DomainGuanylate_kin

MPP1 CASK

4.99e-0326762PF00625
DomainGK/Ca_channel_bsu

MPP1 CASK

4.99e-0326762IPR008145
DomainGuanylate_kin-like_dom

MPP1 CASK

4.99e-0326762IPR008144
DomainGuKc

MPP1 CASK

4.99e-0326762SM00072
DomainHRM

GLP1R ADCYAP1R1

5.77e-0328762PF02793
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.10e-087614M27339
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.10e-087614MM15081
PathwayBIOCARTA_CHREBP_PATHWAY

MLXIPL ACSM1 ADCY1

9.05e-0610613MM1530
PathwayBIOCARTA_CHREBP_PATHWAY

MLXIPL ACSM1 ADCY1

7.11e-0519613M22004
Pubmed

Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

2.10e-11476412637262
Pubmed

Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.46e-09876411395011
Pubmed

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.46e-09876424393035
Pubmed

Similar effects of all WNK3 variants on SLC12 cotransporters.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.46e-09876421613606
Pubmed

Cation-chloride cotransporters and neuronal function.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

2.63e-09976419323993
Pubmed

A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.

SLC12A6 SLC12A4 SLC12A7

1.00e-08376311551954
Pubmed

Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.

SLC12A6 SLC12A4 SLC12A7

1.00e-08376315262997
Pubmed

K-Cl cotransporter gene expression during human and murine erythroid differentiation.

SLC12A6 SLC12A4 SLC12A7

1.00e-08376321733850
Pubmed

Rare independent mutations in renal salt handling genes contribute to blood pressure variation.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.49e-072276418391953
Pubmed

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.

CCNF USP20 USP33

2.00e-07676323486064
Pubmed

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).

SLC12A6 SLC12A4 SLC12A7

5.57e-07876312386165
Pubmed

Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.

SLC12A6 SLC12A7 SLC12A5

8.34e-07976314532115
Pubmed

Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4.

SLC12A7 SLC12A5

4.71e-06276220516068
Pubmed

Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.

SLC12A6 SLC12A4

4.71e-06276234031912
Pubmed

Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter.

SLC12A7 SLC12A5

4.71e-06276212106695
Pubmed

SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus.

SLC12A6 SLC12A7

4.71e-06276231393094
Pubmed

CD33 and SIGLECL1 Immunoglobulin Superfamily Involved in Dementia.

CD33 SIGLECL1

4.71e-06276232647856
Pubmed

Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.

SLC12A6 SLC12A4

4.71e-06276217510708
Pubmed

Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.

SLC12A6 SLC12A7

4.71e-06276210347194
Pubmed

Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion.

DAB2 IRF8

4.71e-06276211823414
Pubmed

Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia.

SLC12A6 SLC12A4

4.71e-06276231835175
Pubmed

The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55.

GPRASP1 GPR55

4.71e-06276221718301
Pubmed

Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.

USP20 USP33

4.71e-06276233792613
Pubmed

Murine Leukemia Virus P50 Protein Counteracts APOBEC3 by Blocking Its Packaging.

APOBEC3D APOBEC3B

1.41e-05376232641479
Pubmed

APOBEC3 deletion increases the risk of breast cancer: a meta-analysis.

APOBEC3D APOBEC3B

1.41e-05376227602762
Pubmed

Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia.

PTGER3 PTGS1

1.41e-05376222397921
Pubmed

Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.

SLC12A6 SLC12A4

1.41e-05376231352162
Pubmed

A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice.

APOBEC3D APOBEC3B

1.41e-05376222691411
Pubmed

Studies on the restriction of murine leukemia viruses by mouse APOBEC3.

APOBEC3D APOBEC3B

1.41e-05376222666481
Pubmed

APOBEC3 deletion polymorphism is associated with epithelial ovarian cancer risk among Chinese women.

APOBEC3D APOBEC3B

1.41e-05376224577894
Pubmed

APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism.

APOBEC3D APOBEC3B

1.41e-05376216648136
Pubmed

Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.

APOBEC3D APOBEC3B

1.41e-05376223533681
Pubmed

Spontaneous recovery from Friend retrovirus-induced leukemia. Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC.

APOBEC3D APOBEC3B

1.41e-0537621541833
Pubmed

In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.

APOBEC3D APOBEC3B

1.41e-05376227356895
Pubmed

IFN-α treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.

APOBEC3D APOBEC3B

1.41e-05376223315078
Pubmed

Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response.

APOBEC3D APOBEC3B

1.41e-05376225589647
Pubmed

Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex.

APOBEC3D APOBEC3B

1.41e-05376223671100
Pubmed

Structural perspectives on HIV-1 Vif and APOBEC3 restriction factor interactions.

APOBEC3D APOBEC3B

1.41e-05376231518043
Pubmed

APOBEC3 signature mutations in chronic lymphocytic leukemia.

APOBEC3D APOBEC3B

1.41e-05376224840555
Pubmed

IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.

SLC12A6 SLC12A7

1.41e-05376217133354
Pubmed

Requirement for CD4(+) T cells in the Friend murine retrovirus neutralizing antibody response: evidence for functional T cells in genetic low-recovery mice.

APOBEC3D APOBEC3B

1.41e-0537629765497
Pubmed

Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.

USP20 USP33

1.41e-05376212865408
Pubmed

Biochemical and biological studies of mouse APOBEC3.

APOBEC3D APOBEC3B

1.41e-05376224453360
Pubmed

APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription.

APOBEC3D APOBEC3B

1.41e-05376223449789
Pubmed

APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice.

APOBEC3D APOBEC3B

1.41e-05376218434399
Pubmed

Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection.

APOBEC3D APOBEC3B

1.41e-05376219153238
Pubmed

Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection.

APOBEC3D APOBEC3B

1.41e-05376218772436
Pubmed

Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes.

SLC12A6 SLC12A4

1.41e-05376235274823
Pubmed

Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo.

APOBEC3D APOBEC3B

1.41e-05376218786991
Pubmed

Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.

APOBEC3D APOBEC3B

1.41e-053762286744
Pubmed

Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning.

SLC12A6 SLC12A5

1.41e-05376222252133
Pubmed

Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3.

APOBEC3D APOBEC3B

1.41e-05376224725948
Pubmed

The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3.

APOBEC3D APOBEC3B

1.41e-05376220702647
Pubmed

Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.

APOBEC3D APOBEC3B

1.41e-05376220980520
Pubmed

Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.

APOBEC3D APOBEC3B

1.41e-053762284359
Pubmed

Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.

APOBEC3D APOBEC3B

1.41e-05376220617165
Pubmed

Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice.

APOBEC3D APOBEC3B

1.41e-05376231801862
Pubmed

Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain.

APOBEC3D APOBEC3B

1.41e-05376239208378
Pubmed

Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure.

APOBEC3D APOBEC3B

1.41e-05376231943071
Pubmed

Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.

USP20 USP33

1.41e-05376212056827
Pubmed

NudC-like protein 2 restrains centriole amplification by stabilizing HERC2.

NUDCD2 USP33

1.41e-05376231427565
Pubmed

Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.

APOBEC3D APOBEC3B

1.41e-05376220566830
Pubmed

Role of adenylate cyclase 1 in retinofugal map development.

EN1 ADCY1

1.41e-05376222102330
Pubmed

Chromosome mapping of Rfv3, a host resistance gene to Friend murine retrovirus.

APOBEC3D APOBEC3B

1.41e-0537627884913
Pubmed

N-linked glycosylation protects gammaretroviruses against deamination by APOBEC3 proteins.

APOBEC3D APOBEC3B

1.41e-05376225505062
Pubmed

Molecular analysis of γ1, γ3, and α class switch recombination junctions in APOBEC3-deficient mice using high-throughput sequencing.

APOBEC3D APOBEC3B

1.41e-05376231595054
Pubmed

Role of APOBEC3 in genetic diversity among endogenous murine leukemia viruses.

APOBEC3D APOBEC3B

1.41e-05376217967065
Pubmed

Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.

APOBEC3D APOBEC3B

1.41e-05376220335265
Pubmed

Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.

SLC12A6 SLC12A7

1.41e-05376224089410
Pubmed

Deaminase-Dead Mouse APOBEC3 Is an In Vivo Retroviral Restriction Factor.

APOBEC3D APOBEC3B

1.41e-05376229593034
Pubmed

Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family.

SLC12A4 SLC12A5

1.41e-05376212739168
Pubmed

Mouse APOBEC3 interferes with autocatalytic cleavage of murine leukemia virus Pr180gag-pol precursor and inhibits Pr65gag processing.

APOBEC3D APOBEC3B

1.41e-05376231830125
Pubmed

Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.

APOBEC3D APOBEC3B

1.41e-05376221998583
Pubmed

Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway.

APOBEC3D APOBEC3B

1.41e-05376238115583
Pubmed

Effects of zidovudine on Friend virus complex infection in Rfv-3r/s genotype-containing mice used as a model for HIV infection.

APOBEC3D APOBEC3B

1.41e-0537622157836
Pubmed

Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells.

APOBEC3D APOBEC3B

1.41e-05376235458563
Pubmed

Two genetic determinants acquired late in Mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency.

APOBEC3D APOBEC3B

1.41e-05376222275865
Pubmed

Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.

APOBEC3D APOBEC3B

1.41e-053762293683
Pubmed

Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene.

APOBEC3D APOBEC3B

1.41e-05376219150103
Pubmed

Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters.

SLC12A6 SLC12A7

1.41e-05376212657561
Pubmed

Initial sequencing and comparative analysis of the mouse genome.

APOBEC3D APOBEC3B

1.41e-05376212466850
Pubmed

Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling.

USP20 USP33

2.82e-05476221525354
Pubmed

Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo.

APOBEC3D APOBEC3B

2.82e-05476218983852
Pubmed

APOBEC3 regulates keratinocyte differentiation and expression of Notch3.

APOBEC3D APOBEC3B

2.82e-05476231400166
Pubmed

Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.

APOBEC3D APOBEC3B

2.82e-05476223725696
Pubmed

APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.

APOBEC3D APOBEC3B

2.82e-05476221985787
Pubmed

APOBEC3A functions as a restriction factor of human papillomavirus.

APOBEC3D APOBEC3B

2.82e-05476225355878
Pubmed

Human and murine APOBEC3s restrict replication of koala retrovirus by different mechanisms.

APOBEC3D APOBEC3B

2.82e-05476226253512
Pubmed

Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains.

APOBEC3D APOBEC3B

2.82e-05476217020885
Pubmed

Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in friend virus-infected mice.

APOBEC3D APOBEC3B

2.82e-05476220375169
Pubmed

APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions.

APOBEC3D APOBEC3B

2.82e-05476221147467
Pubmed

Mice deficient in APOBEC2 and APOBEC3.

APOBEC3D APOBEC3B

2.82e-05476216055735
Pubmed

The incorporation of APOBEC3 proteins into murine leukemia viruses.

APOBEC3D APOBEC3B

2.82e-05476218572219
Pubmed

Restriction of foamy viruses by APOBEC cytidine deaminases.

APOBEC3D APOBEC3B

2.82e-05476216378963
Pubmed

Multifaceted HIV-1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s.

APOBEC3D APOBEC3B

2.82e-05476232893454
Pubmed

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.

APOBEC3D APOBEC3B

2.82e-05476215269786
Pubmed

Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection.

APOBEC3D APOBEC3B

2.82e-05476224821801
Pubmed

Small molecular compounds inhibit HIV-1 replication through specifically stabilizing APOBEC3G.

APOBEC3D APOBEC3B

2.82e-05476220363737
Pubmed

Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils.

APOBEC3D APOBEC3B

2.82e-05476229343743
Pubmed

APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses.

APOBEC3D APOBEC3B

2.82e-05476215674295
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

IL12RB1 IL13RA1 IL20RB IL27RA

9.09e-0642574602
GeneFamilyApolipoprotein B mRNA editing enzyme catalytic subunits

APOBEC3D APOBEC3B

6.32e-0412572406
GeneFamilySolute carriers

SLC12A6 SLC35G1 SLC12A4 SLC6A5 SLC12A7 SLC12A5

1.48e-03395576752
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

MPP1 CASK

3.02e-0326572904
CoexpressionFOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP

COL4A4 SLC35G1 TNFRSF25 DNAH3 SERPINE3 INSIG1 ACSM1 IRF8 HEPH CASK

5.83e-065877410M40869
CoexpressionSRC_UP.V1_UP

COL4A4 MLXIPL AAAS IRF8 GPR55 FUT5

1.14e-05178746M2714
CoexpressionGSE9006_TYPE_1_DIABETES_AT_DX_VS_1MONTH_POST_DX_PBMC_DN

CCNF DAB2 BACE1 ADAMTS5 SLC66A1 SLC12A5

2.02e-05197746M5786
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3

TICRR MLXIPL TCERG1L SLC12A4 SEMA5B GUCY2D DAB2 IRF8 ADAMTS5 SLC12A7 EN1 PTGER3

4.43e-0510747412M1941
ToppCellLPS_only-Endothelial-Epi-like|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL4A4 SLC35G1 MLXIPL IL20RB ADCY1 PTGS1

7.97e-081267664c598f7bae09aca7a4ecce63dfd6890b26468c73
ToppCellLPS_only-Endothelial-Epi-like-Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL4A4 SLC35G1 MLXIPL IL20RB ADCY1 PTGS1

7.97e-08126766e065304f480a5e38532b66508b0ee87cc48bba9b
ToppCell10x5'-blood-Myeloid_Dendritic|blood / Manually curated celltypes from each tissue

IL13RA1 OR10A2 CD33 GUCY2D LRRC26 LILRA4

5.54e-071757661c48eec300d5a6d4a810947b995af3b8c0a5a601
ToppCellmild-Myeloid-pDC|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TLCD1 GUCY2D LRRC26 DAB2 IRF8 LILRA4

6.54e-0718076638614155fa537d0defda914c531c697be0ef06d8
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MPP1 INSIG1 DAB2 IRF8 HSD17B14 PTGS1

7.20e-071837664cc0961a67de76b8d756cd9ffcaa98e3fe3c3a69
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD33 INSIG1 DAB2 IRF8 HSD17B14 PTGS1

8.69e-071897660a490730cdc912d5233de59057550de0e4065747
ToppCellBLOOD--(3)_DC_(cDC+pDC)| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

IL13RA1 CD33 LRRC26 DAB2 IRF8 LILRA4

9.53e-07192766e290c55a1321e9e577f49e8ba20501b2c8150044
ToppCellsevere-Myeloid-pDC|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TLCD1 GUCY2D LRRC26 IRF8 LILRA4

8.30e-061617659e8e8ac11f7fb8c8697357c21034b613f191db2b
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RGSL1 CD33 DAB2 PKHD1 PTGS1

9.62e-06166765bb8135119dc37fdbba476599a56d368f422688dc
ToppCell10x5'-blood-Myeloid_Dendritic-pDC|blood / Manually curated celltypes from each tissue

OR10A2 GUCY2D LRRC26 IRF8 LILRA4

1.08e-0517076559cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCellCOVID_vent-Lymphocytic-Dendritic-pDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.11e-05171765779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCellCOVID_vent-Lymphocytic-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.11e-05171765debbb071d260639b16269c94d172766908325c58
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|normal_Lymph_Node / Location, Cell class and cell subclass

LRRC26 DAB2 IRF8 SIGLECL1 LILRA4

1.24e-0517576529fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCellmild-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TLCD1 LRRC26 DAB2 IRF8 LILRA4

1.28e-0517676559a9c262c252b7d220a025837922d98e9d6b0a24
ToppCellLeuk-UTI-Other-RBC|Leuk-UTI / Disease, Lineage and Cell Type

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.62e-051857655b5dd856d6efc0539d92533cff134bbc3f98be45
ToppCellHealthy_donor-pDC|Healthy_donor / disease group, cell group and cell class (v2)

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.62e-051857657fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCellLeuk-UTI-Other|Leuk-UTI / Disease, Lineage and Cell Type

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.62e-05185765895e8087e97ac0eab3446385e6e0dd24bea7f42c
ToppCellcontrol-Myeloid-pDC|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.67e-05186765fe31e9cf4575ee40b50489593c51d8c36c3cc532
ToppCellcontrol-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.67e-05186765fccee4cfcc887358cf916d974f29627095b5ad9c
ToppCellPBMC-Mild-Myeloid-pDC-pDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.75e-0518876589411c4db3df5e1dc36cf8af4ffcc0abbecbe4df
ToppCellPBMC-Mild-Myeloid-pDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.75e-05188765de6a270b6e4fe09c39a52c296632d86ada98465b
ToppCellPBMC-Mild-Myeloid-pDC-pDC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.75e-05188765879054b780378ae05be68e597c77c931bf0ade03
ToppCellPBMC-Mild-Myeloid-pDC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.80e-05189765209cae68d78c8f72479b169e27c3ff7e143adece
ToppCellPBMC-Mild-Myeloid-pDC-pDC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.80e-05189765a9ad1fb12304541f909dd0eeac9b9eb28c31fd41
ToppCellCOVID-19_Mild-Myeloid-pDC|COVID-19_Mild / Disease group, lineage and cell class

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.80e-05189765c6cfd6aa21c19f2c62d80218bbc924e14e82aada
ToppCellPBMC-Mild-Myeloid-pDC-pDC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.80e-0518976598ca646231fbd5f29827c2dd31ac4503026bad7d
ToppCell(011)_pDC|World / immune cells in Peripheral Blood (logTPM normalization)

GUCY2D LRRC26 DAB2 IRF8 LILRA4

1.89e-05191765d82ac4f6d9863734e09bf3cb71c1354a49b66b4f
ToppCell(01)_Dendritic_cell|World / immune cells in Peripheral Blood (logTPM normalization)

IL13RA1 LRRC26 DAB2 IRF8 LILRA4

1.89e-051917651f4c8078e1a6cd14937c714330af608caced2acf
ToppCellFetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MPP1 CD33 INSIG1 DAB2 IRF8

1.99e-051937652d0dd2671ff27b922eb316f1ed0140353536ef30
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GUCY2D LRRC26 IRF8 GPR55 LILRA4

2.09e-05195765d8fa96c8f14bd088c3f8bd14f894a2c5b7ad46a7
ToppCellBronchus_Control_(B.)-Immune-TX-TRAM-1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

SLC12A6 COL4A4 ACSM1 HSD17B14 LILRA4

2.09e-05195765dabf667875ed48fdce4f803f5ead39c71a6df42b
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IL13RA1 CD33 LRRC26 IRF8 LILRA4

2.20e-0519776589fe4885efc8db142c0dc0506840ae8aceba9ef9
ToppCelldistal-Hematologic-Alveolar_Macrophage-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MPP1 CD33 DAB2 IRF8 LILRA4

2.25e-05198765e1dc5a56fc23d3b1b4350d7162acec5762115b64
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Myeloid-Microglia|GW26 / Sample Type, Dataset, Time_group, and Cell type.

IL13RA1 CD33 DAB2 IRF8 PTGS1

2.25e-05198765c0d33629438504a1545e07f0e5af2e76f50fd55b
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Myeloid|GW26 / Sample Type, Dataset, Time_group, and Cell type.

IL13RA1 CD33 DAB2 IRF8 PTGS1

2.25e-051987652b93995f66c7352acc25d6c71d025b847881dacd
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MPP1 IL13RA1 CD33 DAB2 SLC12A5

2.30e-051997654e552015989defc32fe9068e0ba28521b2a1a09c
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MPP1 IL13RA1 CD33 DAB2 IRF8

2.30e-05199765c4fc638a8dad3a9b77634e8912a9326c8a2f11f5
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MPP1 IL13RA1 CD33 DAB2 SLC12A5

2.30e-0519976542d57522aa05892f37790d0039d936e065565359
ToppCellcellseq2-Immune-Immune_Myeloid-IM-IM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MPP1 CD33 DAB2 IRF8 PTGS1

2.30e-05199765372fb9eb90022dc4ac770a75b4e207c33d1d0c43
ToppCellTransverse-Macrophage-LYVE1_Macrophage|Transverse / Region, Cell class and subclass

MLXIPL IL13RA1 DAB2 SLC12A7 SLC12A5

2.30e-05199765facf79c256db5ae57bdb613e86ec90616a6f67ca
ToppCellTransverse-(6)_Macrophage-(61)_LYVE1_Macrophage|Transverse / shred on region, Cell_type, and subtype

MLXIPL IL13RA1 DAB2 SLC12A7 SLC12A5

2.30e-05199765dcc2a7f4d1fa30aaaad655dd59c5a2b039d264bf
ToppCellcellseq2-Immune-Immune_Myeloid-IM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MPP1 CD33 DAB2 IRF8 PTGS1

2.30e-05199765dd3bf59cdc18091889cbf6c43f37100ba537843d
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Myeloid-Microglia|GW23 / Sample Type, Dataset, Time_group, and Cell type.

IL13RA1 CD33 DAB2 IRF8 PTGS1

2.30e-051997654ddfbcaa8054b69b3398d8c0d5fab8ae94805cb9
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MPP1 IL13RA1 CD33 DAB2 IRF8

2.30e-05199765697a9a58c0cdb77222700d029873355d37f6ab28
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MPP1 IL13RA1 CD33 DAB2 SLC12A5

2.30e-051997650554f41ae53c275c92fe692bd999d7578d244fce
ToppCell(1)_T_cell-(18)_cycling_gd_T|(1)_T_cell / shred on Cell_type and subtype

CCNF TICRR GUCY2D LRRC26 APOBEC3B

2.30e-051997659369d0e4efe809e3e8757294ebebba5a47b30528
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Myeloid|GW23 / Sample Type, Dataset, Time_group, and Cell type.

IL13RA1 CD33 DAB2 IRF8 PTGS1

2.30e-051997653ba48a4715d5e9387650aa97e0c5d7f7897bf380
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal|GW23 / Sample Type, Dataset, Time_group, and Cell type.

IL13RA1 DAB2 IRF8 SLC12A7 PTGS1

2.36e-052007650eccf41edefc3b8b5d0316f57d5ba572949aec2b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal-BMP_responsible_cell|GW23 / Sample Type, Dataset, Time_group, and Cell type.

IL13RA1 DAB2 IRF8 SLC12A7 PTGS1

2.36e-0520076501d707c4f8ee0daac635b7260937b1baebc6fc23
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MLXIPL IL13RA1 CD33 APOBEC3B PTGS1

2.36e-05200765a1503bcc774bed9563eda7cf90b8b5bf4405ad85
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MLXIPL IL13RA1 CD33 APOBEC3B PTGS1

2.36e-0520076525247f8b6ba6cd899ba6bd47e28e090d697e4632
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal|GW10 / Sample Type, Dataset, Time_group, and Cell type.

MPP1 IL13RA1 DAB2 IRF8 PTGS1

2.36e-052007655c638c80661017c85f9390f1b398ac7728c8f001
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal-BMP_responsible_cell|GW10 / Sample Type, Dataset, Time_group, and Cell type.

MPP1 IL13RA1 DAB2 IRF8 PTGS1

2.36e-05200765604a88633d4162337e394155c7346dbdef8b9f5a
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

MPP1 CD33 DAB2 IRF8 HSD17B14

2.36e-052007653cfb28299a55fc1c150262a7333c59a48ae65ad1
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gabrg1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IL13RA1 TCERG1L GLP1R DAB2

4.99e-051187643f0a304ef9c9e5ba047fc09f4372590eed624328
ToppCell|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TICRR ADAMTS5 PTGER3 PTGS1

5.50e-05121764da8fe561dcf50792d0cbcaad383d564f900a6677
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_PT|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TCERG1L ENC1 PTGS1 RYR3

8.17e-05134764cb676d5bbc468bd3ce1b6712d41c986ee9221ac5
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERPINE3 RGSL1 SSPOP HEPH

9.16e-05138764c1a46fbf1beffa12c3d1b78361e0613e2e9e2d13
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERPINE3 RGSL1 SSPOP HEPH

1.02e-0414276467d4ff3483ae34f77c3325aa0fbd3462ca19ade4
ToppCellPND28-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RGSL1 ACSM1 LRRC26 PKHD1

1.11e-041457649b69bfdbf91ef197b4c483617aa67498d9d2cd79
ToppCellPND28-Epithelial-Epithelial_Airway-Neurosecretory-Secretory|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RGSL1 ACSM1 LRRC26 PKHD1

1.11e-0414576431af9fce1dcd7e8ae1604476598e099232017ee9
ToppCellPND28-Epithelial-Epithelial_Airway-Neurosecretory|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RGSL1 ACSM1 LRRC26 PKHD1

1.11e-0414576476f0cde9acdc3ad5948c007dccf312665972c9e6
ToppCellInt-URO-Other|Int-URO / Disease, Lineage and Cell Type

TLCD1 LRRC26 IRF8 LILRA4

1.30e-04151764ea5f25842e621be41a6491c9959d419d9cc7ebd6
ToppCellInt-URO-Other-RBC|Int-URO / Disease, Lineage and Cell Type

TLCD1 LRRC26 IRF8 LILRA4

1.30e-041517640344d482f1c55c9eaa15beb8d6bac1c6cdca21b3
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGSL1 IRF8 PTGER3 PTGS1

1.51e-041577647fdc0094dd5729990a91a30c1982a14c74650b52
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-microglial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGSL1 IRF8 PTGER3 PTGS1

1.51e-04157764c762b03e254c73222094725ca8ac1c8eb428bccb
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGSL1 IRF8 PTGER3 PTGS1

1.51e-041577646b5b08bb5520fcf6f4c0560f7ed7645ec179806d
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

LRRC26 DAB2 IRF8 LILRA4

1.54e-041587642af7beb48272e5368d9ba6b80f08d47ab8556c08
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLC35G1 TNFRSF25 GPR55 CASK

1.58e-041597646599707107083af6da092fe8984afc8fd89d2bb8
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SLC35G1 TNFRSF25 GPR55 CASK

1.58e-04159764916d070d099726f22deb71966efccff00f8ea071
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL12RB1 TNFRSF25 ACSM1 IL27RA

1.62e-041607648308ca6f37986c526432a0fbc5f7ec2e75cfb6d7
ToppCellPND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TICRR IL13RA1 IRF8 SSPOP

1.66e-0416176476c993a4533362db2250c88b3ee3ede55362d54e
ToppCellnormal_Lung-Myeloid_cells-Undetermined|Myeloid_cells / Location, Cell class and cell subclass

GPRASP1 GPR55 LILRA4 SLC12A5

1.66e-04161764283012858e575c70d09950de53da041509f59bfa
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL4A4 MLXIPL PTGS1 USP33

1.70e-0416276406f5d6c0bb26fe9d5180bc2ebf2c54bf52e715f3
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL4A4 MLXIPL PTGS1 USP33

1.70e-04162764d0d9c18a73bc0bf4f38308ef2eee8ae20f6a7918
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Tmem132c_(SN/VTA_(SNr))--|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CCNF SLC6A5 HSD17B14

1.71e-0463763e1b68ef6123ad084ce602b09fd1ba394785797e5
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Tmem132c_(SN/VTA_(SNr))|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CCNF SLC6A5 HSD17B14

1.71e-04637639bfd9ba1335a155ed9e56dd41dd3621b37d4234e
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Tmem132c_(SN/VTA_(SNr))-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CCNF SLC6A5 HSD17B14

1.71e-04637639a90c761898618fc7e5e2984baa1021b74d4ac39
ToppCellmetastatic_Brain-Myeloid_cells-pDCs|metastatic_Brain / Location, Cell class and cell subclass

SDR42E2 LRRC26 IRF8 LILRA4

1.78e-0416476406db4cc064f0765c481ce880207823872c27bfa9
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_LINC00507_PSRC1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TCERG1L LRRIQ1 ENC1 PTGER3

1.82e-041657646de69b75174731931e7e80a3488f983a7ba4defe
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL12RB1 TICRR TNFRSF25 IL27RA

1.82e-0416576426c750f10f6401752e2e63d91dc844c81b29d735
ToppCellInt-URO-Myeloid-tDC|Int-URO / Disease, Lineage and Cell Type

DAB2 IRF8 LILRA4 SLC12A5

1.82e-041657649803c3db6cdcf925bea7d9c382bf4fd05acf3509
ToppCellsevere-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TLCD1 LRRC26 IRF8 LILRA4

1.86e-04166764ae38850fde549b8dd6fb12f0ef80b428ade50485
ToppCell368C-Myeloid-Dendritic-pDC|368C / Donor, Lineage, Cell class and subclass (all cells)

APOBEC3D LRRC26 IRF8 LILRA4

1.91e-041677641e2fc1637769405a61f4c7e44945712a1888a299
ToppCellChildren_(3_yrs)-Immune-enucleated_erythrocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

AAAS SLC12A7 USP20 RYR3

1.95e-041687648f0c4dfad9f6fed9dcc31795abfe77758ceb46a1
ToppCellB_cells-pDCs|World / Immune cells in Kidney/Urine in Lupus Nephritis

GUCY2D LRRC26 IRF8 LILRA4

1.95e-04168764dc8f94424f60ab56facdcffa969e7f3466ee1b6e
ToppCell10x5'-lymph-node_spleen-Myeloid_Dendritic-pDC|lymph-node_spleen / Manually curated celltypes from each tissue

GUCY2D LRRC26 DAB2 LILRA4

1.95e-04168764cfed36fece51871a5abbcde71f6bd5e7212357ff
ToppCell390C-Lymphocytic-NK_cells-Proliferating_NK_cell|390C / Donor, Lineage, Cell class and subclass (all cells)

CCNF TRIM66 TICRR APOBEC3B

2.04e-041707645319f73cff64f2bb67472c7156ee1d0f006c6fc0
ToppCellICU-SEP-Myeloid-pDC|ICU-SEP / Disease, Lineage and Cell Type

LRRC26 DAB2 IRF8 LILRA4

2.09e-0417176472c448a0dc4c569bd6b465f9aa395f38034e7ea6
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 TNFRSF25 RGSL1 IL27RA

2.09e-04171764246fc7edcefc47437d1df6029f295aca3b34b2b2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GUCY2D LRRC26 IRF8 LILRA4

2.09e-04171764af1c93eb75f45c042ea475d93db56e4da207e31f
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-Ly6g5b+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 TNFRSF25 RGSL1 IL27RA

2.09e-041717641fb4e11f92b48dc2d6e553c22e2571bbd8c223c6
ToppCellCOVID-pDC|COVID / Condition, Cell_class and T cell subcluster

GUCY2D LRRC26 IRF8 LILRA4

2.14e-041727643ecbb000495dde32f6153ef6bdea9c8802ff3985
ToppCellBronchial_Biopsy-Immune-Mast_cells|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

MPP1 CD33 HSD17B14 PTGS1

2.14e-04172764c477008444d2d71071177807870d7455e90c2fad
ToppCelllymphoid-B_cell-pro-B|B_cell / Lineage, cell class and subclass

MPP1 TICRR DAB2 BACE1

2.14e-04172764da1e2e54f442f5c2032c857c4812e9060f2053cd
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-stromal_related|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ENC1 ACSM1 PTGER3 IL27RA

2.14e-04172764a03f30a996a9474ad4cccd209476423a042df002
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ENC1 ACSM1 PTGER3 IL27RA

2.14e-04172764f92a53ad2e464cd68ba1714bcc1d5911479cdf1c
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-CD141+_DCs|Myeloid_cells / Location, Cell class and cell subclass

COL4A4 TLCD1 TCERG1L IRF8

2.14e-041727641215f61f115b042f84721b64c2ed1f48081535f1
ToppCellCOVID-pDC-|COVID / Condition, Cell_class and T cell subcluster

GUCY2D LRRC26 IRF8 LILRA4

2.14e-04172764a7827faa1afab51fdaf0cb1a2babcd2e00d411e5
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL12RB1 TNFRSF25 RGSL1 IL27RA

2.18e-041737640a355386210a13927ea29b10b64cb059459952d4
DrugPotassium Chloride

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.71e-096764DB00761
DrugBumetanide

SLC12A6 SLC12A4 SLC12A7 PTGS1

2.02e-0716764ctd:D002034
Drugfurosemide

SLC12A6 TNFRSF25 SLC12A4 SLC6A5 SLC12A7 ADCY1 PTGS1 SLC12A5

3.50e-06272768CID000003440
DrugDCPIB

SLC12A6 SLC12A4 SLC12A5

5.79e-0611763CID010071166
Drug((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy)acetic acid

SLC12A4 SLC12A7

1.10e-052762ctd:C095651
DrugFurosemide

SLC12A6 TNFRSF25 SLC12A4 SLC12A7 PTGS1 SLC12A5

1.84e-05164766ctd:D005665
Disease4-hydroxyphenylacetylglutamine measurement

DNAH3 ACSM1

1.71e-053712EFO_0800688
DiseaseAutosomal Recessive Polycystic Kidney Disease

NPHP3 PKHD1

2.03e-049712C0085548
Diseasemyeloid cell surface antigen CD33 measurement

CD33 SIGLECL1

5.87e-0415712EFO_0008238
DiseaseBenign Neoplasm

GLP1R GPR55 APOBEC3B

5.98e-0468713C0086692
DiseaseNeoplasms

GLP1R GPR55 APOBEC3B

5.98e-0468713C0027651
Diseaseepilepsy (implicated_via_orthology)

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.54e-04163714DOID:1826 (implicated_via_orthology)
Diseasediastolic blood pressure, body mass index

GLP1R SAYSD1

6.70e-0416712EFO_0004340, EFO_0006336
Diseaseglaucoma (is_marker_for)

PTGS1 HEPH

1.05e-0320712DOID:1686 (is_marker_for)
DiseaseSchizophrenia

ACSM1 SLC6A5 BACE1 EN1 PTGER3 PTGS1 ADCYAP1R1 SLC12A5

1.25e-03883718C0036341
Diseasealcohol use disorder (implicated_via_orthology)

GLP1R ADCY1 ADCYAP1R1 RYR3

1.27e-03195714DOID:1574 (implicated_via_orthology)
DiseaseRenal glomerular disease

COL4A4 NPHP3

1.40e-0323712C0268731
DiseaseGlomerulopathy Assessment

COL4A4 NPHP3

1.40e-0323712C4521256
DiseaseCiliopathies

NPHP3 GUCY2D PKHD1

2.40e-03110713C4277690

Protein segments in the cluster

PeptideGeneStartEntry
WQAGTTPWNIFPVIS

BACE1

331

P56817
VWDVSTETCVPLPWF

AAAS

271

Q9NRG9
FNTIWKPWLQPCCGT

ARSH

531

Q5FYA8
TWFVSWNPCLPCVVK

APOBEC3D

101

Q96AK3
FQITWFVSWTPCPDC

APOBEC3B

86

Q9UH17
QPQWVTGPWLACSRT

ADAMTS5

876

Q9UNA0
PPCPQTWRSLWIGYS

COL4A4

1586

P53420
VVWGPSASVAPNAWS

DAB2

571

P98082
SKNWWNCIVTTHGPP

FBXO42

216

Q6P3S6
ELVCTAPQWVPVSWV

CASK

911

O14936
GPVITWHNPVTIWCQ

LILRA4

36

P59901
AQLCAWPWPTDVLTG

MTIF2

46

P46199
VVPCGTPWGQWYQTL

NUDCD2

11

Q8WVJ2
ALVPWGCPWTQAEGT

GUCY2D

146

Q02846
VNVSCPWYLPWASSV

GLP1R

81

P43220
FSSCPSGSIQWIWDV

SLC66A1

11

Q6ZP29
SWACEQGTPPIFSWL

CD33

166

P20138
DWWAQQPSTGVPLVT

IRF8

176

Q02556
VGQYTVQWPGTWCFI

PTGER3

196

P43115
TIFSSAWWVPPCCGT

INSIG1

121

O15503
PWGPCELWVTASTIA

IL27RA

481

Q6UWB1
PNCTIPGLWTWLRNS

PTGS1

66

P23219
PAAQQVSPEWIWACI

LIG3

986

P49916
ICCTIWVLVWTGSIP

GPR55

141

Q9Y2T6
SQQPLVWPAWVYCTR

EN1

266

Q05925
SCGLSFPWPEQVWFK

NPBWR2

196

P48146
HIWIPSSWCSLTEGP

IL20RB

81

Q6UXL0
SVENLCTVIWTWNPP

IL13RA1

41

P78552
CTVIWTWNPPEGASS

IL13RA1

46

P78552
WIPTGLCWSWIPITS

LRRIQ1

931

Q96JM4
IIGWGTPTVCVTVWA

ADCYAP1R1

271

P41586
WFPGFPVATVQTTWL

OR10A2

136

Q9H208
VVGCLPWAWSSKPNS

ADCY1

691

Q08828
SVWACASFQELWPSP

CCNF

71

P41002
WPGQVVICVSSIFWT

DNAH3

1281

Q8TD57
PVSCSWFLWRQPGEF

DCST1

31

Q5T197
VLTCTPWGAPIIWDG

A3GALT2

71

U3KPV4
SWSKWSSPVCVPPEN

IL12RB1

221

P42701
PAQVGDSFGPTWWTC

MAN2C1

66

Q9NTJ4
CISPGNIWTPLWEEL

HSD17B14

181

Q9BPX1
RWTVPATCPQPWRYT

ENC1

471

O14682
DQACSSPQWVPVSWV

MPP1

451

Q00013
LGYSQPWIQVPTSWV

SDR42E2

296

A6NKP2
WPSPWVIVIGSFFST

SLC12A6

566

Q9UHW9
WPSPWVIVIGSFFST

SLC12A7

501

Q9Y666
TLAWPSPWVIVIGSF

SLC12A5

501

Q9H2X9
PIIGSWFWTRVEACV

GPRASP1

611

Q5JY77
WTWPFNTPVALPRCS

FUT5

81

Q11128
TVENSQWSLWPEIPC

RGSL1

41

A5PLK6
HTVCGTEVFGWTPWT

SSPOP

2766

A2VEC9
SFVSVLPWGSCNNPW

SLC6A5

301

Q9Y345
SVNVETCPPAWRLWP

NPHP3

651

Q7Z494
VPWEPGTWLISCQVN

HEPH

336

Q9BQS7
SCSFHGIPTPSVQWW

SIGLECL1

26

Q8N7X8
IGILWPVFTSEPNQW

PKHD1

3241

P08F94
VWTTQPWTIPANEAV

IARS2

296

Q9NSE4
WPPPEQWCKQLFSSV

MLXIPL

211

Q9NP71
WPSPWVIVIGSFFST

SLC12A4

501

Q9UP95
SQNPISCFEWWFPGI

TM4SF20

41

Q53R12
IWTLVEPWTAGCTVF

ACSM1

276

Q08AH1
ASTPVPGSPWCVVWT

TCERG1L

336

Q5VWI1
TPWSPAVVEKWFPFC

TICRR

486

Q7Z2Z1
AGQDPSCVWVGWVTP

RYR3

1336

Q15413
FLTIWTTVVANPGQW

VN1R1

291

Q9GZP7
FSPSVIIILVPCWWH

UNQ5815/PRO19632

71

Q6UWF5
TPLSPCFVEHVSWWA

SERPINE3

121

A8MV23
NTPCPVPIFWASWGS

SEMA5B

716

Q9P283
TPWNTAIPLPSCWDQ

SAYSD1

81

Q9NPB0
WDCIVQTWPAIVSSG

PSME4

1046

Q14997
PETQEALCPQVTWSW

TNFRSF25

286

Q93038
ALCPQVTWSWDQLPS

TNFRSF25

291

Q93038
SCTPSWFWGPVVTLE

USP20

526

Q9Y2K6
IVSGIWALLCVWQTP

TLCD1

56

Q96CP7
WPVPAFDIITQWCFE

UBR3

1706

Q6ZT12
VPTWWTVGGALCVVA

SLC35G1

336

Q2M3R5
CNTDPGSPWSIRFTW

TRIM66

236

O15016
KRFVVSCVPSWFWGP

USP33

551

Q8TEY7
SCVPSWFWGPVVTLQ

USP33

556

Q8TEY7
PRWFPQPTVVWASQV

VTCN1

171

Q7Z7D3
PWPVWAQVSATASPS

LRRC26

21

Q2I0M4