Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentpresynaptic active zone cytoplasmic component

ERC1 PCLO UNC13A

3.27e-0523573GO:0098831
GeneOntologyCellularComponentapoptosome

UACA APAF1

4.37e-054572GO:0043293
GeneOntologyCellularComponentcytoskeleton of presynaptic active zone

ERC1 PCLO

2.02e-048572GO:0048788
GeneOntologyCellularComponentcell cortex region

ERC1 PCLO UNC13A

2.51e-0445573GO:0099738
GeneOntologyCellularComponentinsulin-responsive compartment

MYO5A LRP1

3.95e-0411572GO:0032593
GeneOntologyCellularComponentpresynaptic cytoskeleton

ERC1 PCLO

6.51e-0414572GO:0099569
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

PBRM1 UACA MYO5A CENPE ERC1 PAK5 TBC1D7 SYNE2 LRP1 APPL1 GRIN2A TRIP11 ARPC4 UNC13A

4.64e-10963581428671696
Pubmed

A Saccharomyces cerevisiae assay system to investigate ligand/AdipoR1 interactions that lead to cellular signaling.

ADIPOR1 APPL1

2.73e-06258223762377
Pubmed

Adiponectin inhibits D‑gal‑induced cardiomyocyte senescence via AdipoR1/APPL1.

ADIPOR1 APPL1

2.73e-06258234396435
Pubmed

An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes.

AKAP6 ADCY5

2.73e-06258219574217
Pubmed

Adiponectin receptor binding proteins--recent advances in elucidating adiponectin signalling pathways.

ADIPOR1 APPL1

8.19e-06358220875820
Pubmed

Evidence for decreased expression of APPL1 associated with reduced insulin and adiponectin receptors expression in PCOS patients.

ADIPOR1 APPL1

8.19e-06358227075719
Pubmed

Exercise training performed simultaneously to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in mice.

ADIPOR1 APPL1

8.19e-06358223046739
Pubmed

ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.

ERC1 UNC13A

1.64e-05458228264913
Pubmed

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.

TMEM67 SYNE2

1.64e-05458219596800
Pubmed

Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells.

ADIPOR1 APPL1

1.64e-05458219661063
Pubmed

The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins.

SYNE2 BRAP

1.64e-05458223707952
Pubmed

Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo.

UBE4A APPL1

1.64e-05458237429524
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

PBRM1 STAG1 PCLO SYNE2 APAF1 INTS1 ARPC4

1.89e-0549858736634849
Pubmed

APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function.

ADIPOR1 APPL1

2.72e-05558216622416
Pubmed

Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival phosphatidylinositol 3-kinase/Akt pathway.

APPL1 GRIN2A

2.72e-05558222933778
Pubmed

Human immunodeficiency virus-1 Tat protein increases the number of inhibitory synapses between hippocampal neurons in culture.

LRP1 GRIN2A

2.72e-05558224198379
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

AKAP6 ERC1 SYNE2 APAF1 APPL1

3.76e-0522558512168954
Pubmed

Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release.

PCLO UNC13A

4.08e-05658214734538
Pubmed

A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1.

PCLO UNC13A

4.08e-05658219812333
Pubmed

Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity.

PBRM1 PCLO

4.08e-05658225636086
Pubmed

Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures.

LRP1 GRIN2A

5.71e-05758223267846
Pubmed

Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death.

LRP1 GRIN2A

5.71e-05758219036954
Pubmed

Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis.

UACA APAF1

5.71e-05758215271982
Pubmed

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.

ERC1 UNC13A

5.71e-05758236398873
Pubmed

Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes.

LRP1 GRIN2A

5.71e-05758223760271
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

ERC1 SYNE2 CCDC18 TRIP11 BRAP

6.31e-0525158529778605
Pubmed

HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes.

LRP1 GRIN2A

7.60e-05858217360663
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

MAST4 ERC1 PAK5 SYNE2 DYRK1B CCDC18 TRIP11 ABTB2

8.76e-0586158836931259
Pubmed

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.

PCLO SYNE2 APPL1

1.09e-045558318570454
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

AKAP6 UACA SYNE2 TRIM55 APPL1 TRIP11

1.78e-0449758623414517
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

UACA MYO5A ERC1 FER ZNF281 ARPC4 AP3S2

1.97e-0472458736232890
Pubmed

Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS-Hook-FHIP complexes.

MYO5A APPL1 TRIP11

2.42e-047258334882091
Pubmed

Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.

ERC1 PCLO

2.46e-041458221228161
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

AKAP6 UBE4A STAG1 MYO5A ERC1 LRP1 ZBTB47 APPL1 TRIP11

2.60e-04128558935914814
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

MYO5A PCLO DYRK1B GRIN2A ADCY5

2.85e-0434758517114649
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

NIBAN1 PAK5 PTDSS1 ARHGAP11A ADCY5 UNC13A MYO16

4.00e-0481458723251661
Pubmed

Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.

LRP1 GRIN2A

4.11e-041858219455133
Pubmed

HIV tat and neurotoxicity.

LRP1 GRIN2A

4.59e-041958216697675
Pubmed

Scanning the human proteome for calmodulin-binding proteins.

AKAP6 STAG1 SYNE2

4.97e-049258315840729
Pubmed

mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.

ERC1 UNC13A

5.09e-042058223791195
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

PBRM1 ERC1 PCLO ZBTB47 ZNF281

5.21e-0439658526687479
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF567 PBRM1 STAG1 INTS1 ARHGAP11A ZNF281

5.21e-0460858636089195
Pubmed

mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.

SYNE2 INTS1 BRAP

5.98e-049858334943047
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

MYO5A PCLO PAK5 GRIN2A

6.07e-0423158416452087
Pubmed

Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.

MYO5A PCLO ARPC4 UNC13A

6.27e-0423358429518331
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

KLHL5 PBRM1 MYO5A CENPE

6.37e-0423458436243803
Pubmed

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.

TRIML1 TRIM55 BRAP

7.31e-0410558322493164
Pubmed

Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment.

TRIM55 ARHGAP11A

8.00e-042558215782160
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

MYO5A LRP1 GRIN2A ARPC4

8.28e-0425158427507650
Pubmed

Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.

ERC1 UNC13A

8.66e-042658217124501
Pubmed

Interactome of the negative regulator of nuclear import BRCA1-binding protein 2.

SYNE2 BRAP

8.66e-042658225820252
Pubmed

A germline-specific class of small RNAs binds mammalian Piwi proteins.

TMEM67 ZNF652 LRP1 APPL1 AP3S2

9.25e-0445058516751776
Pubmed

Proteomic profiling of Myc-associated proteins.

AKAP6 ADIPOR1 ERC1

9.28e-0411458321150319
Pubmed

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.

APAF1 GBP3

1.08e-032958233278357
Pubmed

The synaptic vesicle cycle.

PCLO UNC13A

1.23e-033158215217342
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

MYO5A PCLO APPL1 GRIN2A

1.26e-0328158428706196
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

UACA UNC13A MYO16

1.36e-0313058312421765
Pubmed

Biological insights from 108 schizophrenia-associated genetic loci.

PBRM1 STAG1 LRP1 GRIN2A

1.66e-0330358425056061
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_500_k-means-cluster#4

UBE4A KLHL5 CENPE PCLO SYNE2 MAGEE2

1.25e-05192576Facebase_RNAseq_e10.5_Lateral Nasal Eminence_500_K4
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

KLHL5 PCLO SYNE2 GBP3 ZNF281 TRIP11

2.32e-07199586c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TBX22 SYNE2 TRIM55 ADCY5

3.16e-05138584a88c3ae56b0af60f6e87cabade4f21e2bbb336f2
ToppCellLPS-antiTNF-Unknown-Endothelial-Monocytes-Macrophages|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CSF2RB CCDC18 GBP3 ARHGAP11A

3.53e-05142584b66f9602dba30d1d4fbcc49ceb112eb5bd916ba1
ToppCellVE-Treg-naive_CD4|VE / Condition, Cell_class and T cell subcluster

MAST4 ZNF652 SYNE2 AP3S2

5.10e-051565846501baf73616e702946de9fb13d267e30a68888b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO5A ERC1 ABTB2 MYO16

5.91e-05162584285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

CYP4F22 LRRC4C UNC13A MYO16

6.05e-0516358419c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPE CCDC18 ARHGAP11A UNC13A

6.80e-05168584a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPE CCDC18 KCNN4 ARHGAP11A

7.12e-05170584e08a6c5ac34c456da8c7318f104e06fca585be1f
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UACA SYNE2 LRP1 APPL1

7.62e-05173584e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCellfacs-Large_Intestine-Proximal-3m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UACA SYNE2 LRP1 APPL1

7.62e-0517358499532bb768ee35fed939a377acb5215d3f8904bd
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADIPOR1 CENPE CCDC18 ARHGAP11A

7.96e-05175584f7d191cde68de8f3457fa62b1df53b6d0dbe5001
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 STAG1 FER TRIP11

8.14e-05176584749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAG1 SYNE2 GBP3 TRIP11

8.51e-0517858401dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 OLFML2A CPXM2 ADCY5

8.69e-051795848da6863edc756540bb097cc7221c1408640d9bb4
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 OLFML2A CPXM2 ADCY5

8.69e-05179584f39c13c99a07d009cc677e363ffe089089c64916
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NIBAN1 MAST4 CENPE SYNE2

8.88e-051805846bb9f41c3a99d1bbe697f589fb2bcea9b7bfbeee
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 MYO5A PAK5 UNC13A

9.27e-05182584be32b5b8153c1053cbb55f1fccfa27c3ee97c1e1
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AKAP6 OLFML2A CPXM2 LRRC4C

9.27e-05182584a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCellRA-13._Vascular_Smooth_Muscle|RA / Chamber and Cluster_Paper

AKAP6 NIBAN1 CPXM2 ADCY5

9.47e-05183584818fd886e0188091310825f9145fa53328f2c979
ToppCell(1)_T_cells-(1)_T_regulatory|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

NIBAN1 MAST4 KCNN4 ZNF281

9.67e-051845843cbf81757653652441843d85cb7ec1dcf25ca1b0
ToppCellCOVID-19-Heart-CM_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 NIBAN1 TRIM55 ADCY5

9.67e-05184584e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UACA CENPE SYNE2 ARHGAP11A

1.01e-0418658415ab6666748a641226e42e6ca6eeaf186a501c95
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UACA CENPE SYNE2 ARHGAP11A

1.01e-041865844ed1b97e2552f3c4134f25665d7513498ffac16c
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NIBAN1 MAST4 ERC1 KCNN4

1.01e-0418658474eb69a52090f9e2426a47e03a1c478ee0cfec18
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NIBAN1 CENPE CCDC18 ARHGAP11A

1.03e-0418758473931a5ea73799095daff100b5f18853c57c74dc
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

AKAP6 NIBAN1 CPXM2 CHSY3

1.05e-0418858434e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellControl-Fibroblasts-Adventitial_FB|Control / group, cell type (main and fine annotations)

CPXM2 UACA LRP1 ABTB2

1.05e-04188584706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

NIBAN1 CPXM2 PCLO ZMAT1

1.05e-041885840d86044bc340e3efb90d0022dd299873639d831c
ToppCellP07-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

OLFML2A NIBAN1 GRIN2A ADCY5

1.05e-041885846ec22b79b19d57ea187f312907819dc2d01f3efe
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NIBAN1 LRP1 ADCY5 ABTB2

1.07e-0418958445e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

AKAP6 NIBAN1 MAST4 TRIM55

1.09e-0419058493c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellnormal_Pleural_Fluid-T/NK_cells-Treg|T/NK_cells / Location, Cell class and cell subclass

NIBAN1 MAST4 CSF2RB SYNE2

1.09e-04190584519356c4925b5b6647e7d763d4084cd9b2e94f0a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MAST4 GRIN2A LRRC4C MYO16

1.09e-041905841bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCellLV-06._Ventricular_Cardiomyocyte_II|LV / Chamber and Cluster_Paper

AKAP6 NIBAN1 MAST4 ADCY5

1.12e-0419158425f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NIBAN1 CENPE SYNE2 ARHGAP11A

1.12e-04191584912e2d10d3423aa7f708fcf2b11da1845f12d7d3
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 ADCY5 ABTB2 MYO16

1.12e-0419158414057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

AKAP6 NIBAN1 MAST4 TRIM55

1.12e-041915845d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NIBAN1 CENPE SYNE2 ARHGAP11A

1.12e-0419158477a2746b6d9c53b08d4405411c16fcc5a6c734ce
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ERC1 FER TRIM55 ABTB2

1.14e-041925842510f22197502f60fd266b7f42eff040f25b8ae7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ERC1 FER TRIM55 ABTB2

1.14e-04192584e8e316f396834bcd34843e56e1d86f310fd6aada
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MAST4 GRIN2A LRRC4C MYO16

1.14e-0419258425460ca9ebd3d49f666394cf99ab77a5e8f77250
ToppCellILEUM-inflamed-(1)_Tregs|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

NIBAN1 MAST4 SYNE2 ZNF281

1.14e-041925841fe3417dfd1cf1758fd82c9ac13dbd88bdf0b548
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

MAST4 STAG1 ERC1 SYNE2

1.14e-04192584e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AKAP6 OLFML2A NIBAN1 ADCY5

1.16e-04193584469a7f1c2ff7137cc5a064464456911f67f92e70
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NIBAN1 CENPE CCDC18 ARHGAP11A

1.16e-04193584a332dfdcc48c405020014e644aa4d14fda98cc86
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

PBRM1 APPL1 ZNF281 TRIP11

1.16e-04193584abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 MYO5A PCLO PAK5

1.16e-04193584a189d46c39067b717509cd144e0225cc93d7731d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

UACA LRP1 CHSY3 GRIN2A

1.19e-0419458481713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

AKAP6 NIBAN1 MAST4 TRIM55

1.19e-0419458489812fb164065041357bb37a3c2d87028ec3de4e
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

AKAP6 NIBAN1 MAST4 TRIM55

1.19e-04194584c3535f7cc0076653c72db582047cff053c322397
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

UACA LRP1 CHSY3 GRIN2A

1.19e-04194584627cffe2d448e74fc5df92e74e5b922a73304137
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

NIBAN1 MAST4 SYNE2 CHSY3

1.21e-04195584dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NIBAN1 STAG1 LRP1 TRIP11

1.21e-041955845c86fddd6d0530beecf45ea5ba6b823123847696
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCLO PAK5 CHSY3 GRIN2A

1.23e-04196584676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 MYO5A PCLO PAK5

1.23e-0419658436b4f08fc038dfde6343ff0869e1a027d882adb5
ToppCellCOVID-19-lung-Capillary_Aerocytes|lung / Disease (COVID-19 only), tissue and cell type

KLHL5 UACA SYNE2 GRIN2A

1.23e-041965844ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

UACA CENPE CCDC18 KCNN4

1.26e-041975840fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_dorsal_progenitors|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

UACA CENPE CCDC18 ARHGAP11A

1.28e-041985845f0964c3aa7e1dc52cbb46e754078920b65bcb88
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCLO PAK5 CHSY3 GRIN2A

1.28e-041985846d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCLO PAK5 GRIN2A UNC13A

1.28e-041985848ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

UACA CENPE CCDC18 ARHGAP11A

1.28e-04198584629d674a9c9108c1acb3f7af57bbdbf34bb0528e
ToppCellmetastatic_Brain-Fibroblasts-Pericytes|Fibroblasts / Location, Cell class and cell subclass

OLFML2A NIBAN1 UACA SYNE2

1.28e-0419858486a4c8e859ce11a95875f8844963baeb1ba898ec
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCLO PAK5 CHSY3 GRIN2A

1.28e-041985844ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellIPF-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

MAST4 CPXM2 MYO5A SYNE2

1.28e-04198584b8bd1ba268480f54451648e01631b615a3401144
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NIBAN1 MAST4 SYNE2 CHSY3

1.28e-041985841408e02e053ad3406229bfe8189da03be6366e81
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 CPXM2 GRIN2A ADCY5

1.28e-04198584c12e7511628db819a52959bb68580e27c00c2e41
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

SYNE2 CCDC18 APPL1 TRIP11

1.28e-0419858476d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCLO PAK5 CHSY3 GRIN2A

1.28e-041985840ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellLPS_only|World / Treatment groups by lineage, cell group, cell type

MAST4 CSF2RB CENPE GBP3

1.31e-04199584852cf595c2255983cff9045f2bb746d4391cf5ba
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating-cycling_dorsal_progenitors|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

UACA CENPE CCDC18 ARHGAP11A

1.31e-04199584ca17e8c0f5bc2c41ce28351a7418d934404e563b
ToppCellLPS_anti-TNF-Endothelial-Endothelial-FOXM1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

CENPE SYNE2 CCDC18 ARHGAP11A

1.31e-0419958498575fcce726589e93fbb4df1aab03e57cb56076
ToppCellLPS_IL1RA-Endothelial-Endothelial-FOXM1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CENPE SYNE2 CCDC18 ARHGAP11A

1.31e-04199584be2276c9a1994579ba1d2998b49bf549c1324d44
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

KLHL5 SYNE2 APPL1 TRIP11

1.31e-04199584a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / Treatment groups by lineage, cell group, cell type

MAST4 SYNE2 GBP3 LRRC4C

1.33e-04200584b036f5e22c95a3b14391785b6e91aa183b9bc9a8
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Stem_cells-Neuroepithelial_cell|2m / Sample Type, Dataset, Time_group, and Cell type.

CENPE SYNE2 CCDC18 ARHGAP11A

1.33e-042005840d9b8d51a7630e70e60c76c763ff82df4c559152
ToppCellfacs-Brain_Non-Myeloid-Hippocampus|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL5 MAST4 ZNF281 ABTB2

1.33e-04200584fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

MAST4 UACA SYNE2 GBP3

1.33e-04200584edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Stem_cells|2m / Sample Type, Dataset, Time_group, and Cell type.

CENPE SYNE2 CCDC18 ARHGAP11A

1.33e-042005840675f580ccef705875854247bbfd4ee2bcf126a1
ToppCellLPS_only-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

MAST4 UACA SYNE2 GBP3

1.33e-0420058481e76508c9050d533853d5fd2f3097b27613d836
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CENPE SYNE2 CCDC18 ARHGAP11A

1.33e-04200584dd5b753bb1333fa502b9d3a6d65a53a9882b2451
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

PCLO PAK5 CHSY3 GRIN2A

1.33e-0420058448d801219bc771d6c7e151dc88ca4c179988de85
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

OLFML2A MAST4 SYNE2 KCNN4

1.33e-0420058477ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCellNon-neuronal-Dividing-IPC|World / Primary Cells by Cluster

CENPE SYNE2 CCDC18 ARHGAP11A

1.33e-04200584971533181daa1bfac1f1b8c507d2013f891f9078
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

MAST4 LRRC4C UNC13A MYO16

1.33e-042005845c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

MAST4 UACA SYNE2 GBP3

1.33e-042005844bb609a284d4e6066f17470a1736076aa4a1f84c
Diseaseobsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa

AKAP6 STAG1 PCLO SYNE2 GRIN2A

4.28e-05200575EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
DiseaseMajor Depressive Disorder

CSF2RB PCLO APAF1 LRP1 ADCY5

1.07e-04243575C1269683
DiseaseUnipolar Depression

CSF2RB PCLO APAF1 LRP1 ADCY5

1.45e-04259575C0041696
Diseasesusceptibility to common cold measurement

NIBAN1 MYO5A MYO16

1.58e-0454573EFO_0008417
Diseaseurate measurement, bone density

AKAP6 MAST4 CSF2RB ERC1 GBP3 LRRC4C MYO16

1.84e-04619577EFO_0003923, EFO_0004531
Diseasesphingomyelin 14:0 measurement

PAK5 SYNE2

4.89e-0417572EFO_0010390
DiseaseHypermetropia, Myopia

AKAP6 TMEM67 LRRC4C ADCY5

4.94e-04189574HP_0000540, HP_0000545
Diseasecoagulation factor V measurement

MAST4 PAK5

6.81e-0420572EFO_0008087
Diseaseblood pressure

TBC1D7 MYO16

8.26e-0422572EFO_0004325
DiseaseAlzheimer disease, gastroesophageal reflux disease

AKAP6 CENPE ZNF652 LRRC4C

9.95e-04228574EFO_0003948, MONDO_0004975
DiseasePsychotic Disorders

PBRM1 CSF2RB PAK5

9.96e-04101573C0033975

Protein segments in the cluster

PeptideGeneStartEntry
FAQDMKYAMEEHDKH

UNC13A

1091

Q9UPW8
FLAYHMASAKMHKEL

APAF1

486

O14727
EIVHGIMHLYKTNKM

BRAP

136

Q7Z569
EMHVIVEKQLYNHMG

ADAM2

181

Q99965
FHMDKVHYILQEVVM

AP3S2

111

P59780
KQEDMMFHKIYIQKH

ADCY5

451

O95622
FQYGKHMAMSHKINS

PDSS2

281

Q86YH6
LMNQHDTEMKYYIVH

DYRK1B

161

Q9Y463
FKHHNYKEMRQLMKV

CPXM2

316

Q8N436
EEMKQMEVYRSHSKF

ERC1

421

Q8IUD2
HVMKMKHGEAYYSEV

PAK5

171

Q9P286
YMKKAEIEHHEMAKS

PBRM1

281

Q86U86
LQAHHAMEKMEEFVY

ADIPOR1

71

Q96A54
AHHETIKMKVLEYMA

MAGEE2

471

Q8TD90
KHVHNFMMDIQYTKE

KCNN4

296

O15554
MDKNYMAHLVEVQHE

INTS1

1281

Q8N201
NMTNEKMHHYINEVL

MYO16

796

Q9Y6X6
MHMKVYDESIQLDHK

LRP1

1831

Q07954
DVYTSRKKQHQTMMH

APPL1

166

Q9UKG1
RKKQHQTMMHYFCAL

APPL1

171

Q9UKG1
HINDKTSDYEMHKMR

C2CD6

601

Q53TS8
EMYEEMMHKTHKYKA

PCLO

1916

Q9Y6V0
MMHKTHKYKAFPAAN

PCLO

1921

Q9Y6V0
YQQMMEEKEKSYQEH

GBP3

511

Q9H0R5
AVMLVIFYKMRKQHH

LRRC4C

541

Q9HCJ2
DLHKVAHNYTMEHFM

KLHL5

336

Q96PQ7
MKMRYEHIDHTFEIQ

CSF2RB

361

P32927
KEAYHMEMISHQENH

CCDC18

1221

Q5T9S5
YDKATMKLHMLHNQY

FER

171

P16591
DHEIIMMNHVYKERF

MAST4

366

O15021
MAEDTYSHKMVKTNH

DUXA

1

A6NLW8
HMDFEQKYKMVLEEN

CENPE

826

Q02224
YMKIFNQSADIMHAK

CYP4F22

171

Q6NT55
MKVHAYVHKVASQMN

OLFML2A

136

Q68BL7
TFEQSIKAYHMMNKF

TMEM67

866

Q5HYA8
YSTQMKMEHEKDIHS

ARHGAP11A

691

Q6P4F7
HLLQKHKEFRMEMDY

SYNE2

5096

Q8WXH0
HESHAKVMMYRKEQY

TBC1D7

71

Q9P0N9
KTIEISDMKYHIFQM

ABTB2

886

Q8N961
HDLMMSEEQQQHLYK

AKAP6

986

Q13023
MYKHKLVDFVIHFME

ARPC4

126

P59998
QKKSFMMIKYMHDHY

CHSY3

236

Q70JA7
QHLDHAQKTLYMDVM

ZNF567

21

Q8N184
QMEKIEHGYENMNHF

TRIM55

296

Q9BYV6
RHLNHDYMKQMTFEA

NIBAN1

196

Q9BZQ8
MDDKGHIILQSMHKY

TBX22

206

Q9Y458
QCSMKFIQKYHMERH

ZNF281

321

Q9Y2X9
VDMHAAADIFKHYMK

STAG1

881

Q8WVM7
EKKFYTMAHVRKHMV

ZBTB47

526

Q9UFB7
KEIHTYMKMFQRAQE

NPIPB2

191

A6NJ64
QVVVSEYMKMHQFLK

TRIML1

176

Q8N9V2
MYESEGKVKQMQTHF

UACA

506

Q9BZF9
ENSHLKTEYHKMMDI

TRIP11

1111

Q15643
TKVHYGIAKAHQMML

TTC29

396

Q8NA56
HQFMAQFHEKIYQML

UBE4A

371

Q14139
DFNMKQYFDEHMKTH

ZNF652

421

Q9Y2D9
SKDDVNYKMHFRMIN

PTDSS1

11

P48651
KMKMHVENFQVHRYE

ZMAT1

101

Q5H9K5
NMHVFKLEQEEYMKE

MYO5A

466

Q9Y4I1
MHQYMTKFNQKGVED

GRIN2A

701

Q12879