Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1I CACNA1H CACNA1G	5.30e-08	3	76	3	GO:0008332
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1I CACNA1H CACNA1G	1.87e-05	14	76	3	GO:0008331
GeneOntologyMolecularFunction	sodium channel activity	TRPM4 CACNA1I CACNA1H CACNA1G	4.57e-05	52	76	4	GO:0005272
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	CACNA1I CACNA1H CACNA1G	1.29e-04	26	76	3	GO:0005248
GeneOntologyMolecularFunction	calcium channel activity	TRPM4 CACNA1I CACNA1H CACNA1G CNGA4	1.33e-04	129	76	5	GO:0005262
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TRPM4 CACNA1I CACNA1H CACNA1G CNGA4	2.78e-04	151	76	5	GO:0015085
GeneOntologyMolecularFunction	gated channel activity	TRPM4 PIEZO1 LRRC26 CACNA1I CACNA1H CACNA1G CNGA4	2.80e-04	334	76	7	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPM4 PIEZO1 LRRC26 CACNA1I CACNA1H CACNA1G CNGA4	3.29e-04	343	76	7	GO:0005261
GeneOntologyMolecularFunction	glycogen binding	PPP1R3D EPM2A	5.06e-04	9	76	2	GO:2001069
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	TRPM4 LRRC26 CACNA1I CACNA1H CACNA1G	6.52e-04	182	76	5	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	TRPM4 LRRC26 CACNA1I CACNA1H CACNA1G	6.85e-04	184	76	5	GO:0022832
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1I CACNA1H CACNA1G	7.15e-04	46	76	3	GO:0005245
GeneOntologyMolecularFunction	monoatomic ion channel activity	TRPM4 PIEZO1 LRRC26 CACNA1I CACNA1H CACNA1G CNGA4	1.81e-03	459	76	7	GO:0005216
GeneOntologyBiologicalProcess	membrane depolarization during action potential	TRPM4 CACNA1I CACNA1H CACNA1G	9.17e-06	36	76	4	GO:0086010
GeneOntologyBiologicalProcess	positive regulation of calcium ion-dependent exocytosis	CACNA1I CACNA1H CACNA1G	5.24e-05	20	76	3	GO:0045956
GeneOntologyBiologicalProcess	transmission of nerve impulse	SPTBN4 CACNA1I CACNA1H CACNA1G PRX	5.87e-05	112	76	5	GO:0019226
GeneOntologyBiologicalProcess	sodium ion transport	SPTBN4 TRPM4 CACNA1I CACNA1H CACNA1G GNAS CNGA4	6.92e-05	275	76	7	GO:0006814
GeneOntologyCellularComponent	sodium channel complex	TRPM4 CACNA1I CACNA1H CACNA1G	3.58e-06	29	76	4	GO:0034706
GeneOntologyCellularComponent	voltage-gated sodium channel complex	CACNA1I CACNA1H CACNA1G	3.03e-05	17	76	3	GO:0001518
GeneOntologyCellularComponent	cation channel complex	TRPM4 LRRC26 CACNA1I CACNA1H CACNA1G CNGA4	2.15e-04	235	76	6	GO:0034703
GeneOntologyCellularComponent	spectrin	SPTBN4 SPTBN5	4.62e-04	9	76	2	GO:0008091
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1I CACNA1H CACNA1G	6.26e-04	46	76	3	GO:0005891
Domain	VDCC_T_a1	CACNA1I CACNA1H CACNA1G	6.22e-08	3	75	3	IPR005445
Domain	VDCCAlpha1	CACNA1I CACNA1H CACNA1G	7.31e-06	10	75	3	IPR002077
Domain	Ion_trans_dom	TRPM4 CACNA1I CACNA1H CACNA1G CNGA4	9.53e-05	114	75	5	IPR005821
Domain	Ion_trans	TRPM4 CACNA1I CACNA1H CACNA1G CNGA4	9.53e-05	114	75	5	PF00520
Domain	-	PRAMEF7 PODNL1 LRRC75B LRRC10B LRRC26 FBXL19 PRAMEF8	3.03e-04	321	75	7	3.80.10.10
Domain	L_dom-like	PRAMEF7 PODNL1 LRRC75B LRRC10B LRRC26 FBXL19 PRAMEF8	3.45e-04	328	75	7	IPR032675
Domain	PH_dom-spectrin-type	SPTBN4 SPTBN5	5.62e-04	9	75	2	IPR001605
Domain	CYTOCHROME_B5_2	HERC2 NENF	1.21e-03	13	75	2	PS50255
Domain	CYTOCHROME_B5_1	HERC2 NENF	1.21e-03	13	75	2	PS00191
Domain	Cyt-b5	HERC2 NENF	1.40e-03	14	75	2	PF00173
Domain	Cyt_B5-like_heme/steroid-bd	HERC2 NENF	1.40e-03	14	75	2	IPR001199
Domain	Cyt-b5	HERC2 NENF	1.40e-03	14	75	2	SM01117
Domain	-	HERC2 NENF	1.40e-03	14	75	2	3.10.120.10
Domain	Channel_four-helix_dom	CACNA1I CACNA1H CACNA1G	1.56e-03	57	75	3	IPR027359
Domain	-	CACNA1I CACNA1H CACNA1G	1.56e-03	57	75	3	1.20.120.350
Domain	PDZ	ARHGAP23 RGS3 PRX MPP7	2.50e-03	141	75	4	PF00595
Domain	PRAME_family	PRAMEF7 PRAMEF8	2.60e-03	19	75	2	IPR026271
Domain	PDZ	ARHGAP23 RGS3 PRX MPP7	2.98e-03	148	75	4	SM00228
Domain	-	ARHGAP23 RGS3 PRX MPP7	3.12e-03	150	75	4	2.30.42.10
Domain	PDZ	ARHGAP23 RGS3 PRX MPP7	3.20e-03	151	75	4	PS50106
Domain	PDZ	ARHGAP23 RGS3 PRX MPP7	3.27e-03	152	75	4	IPR001478
Domain	Actinin_actin-bd_CS	SPTBN4 SPTBN5	3.81e-03	23	75	2	IPR001589
Domain	Spectrin	SPTBN4 SPTBN5	3.81e-03	23	75	2	PF00435
Domain	ACTININ_2	SPTBN4 SPTBN5	3.81e-03	23	75	2	PS00020
Domain	ACTININ_1	SPTBN4 SPTBN5	3.81e-03	23	75	2	PS00019
Domain	Ankyrin_rpt	TRPM4 ASB10 KANK2 ANKRD33B KRIT1	4.06e-03	262	75	5	IPR002110
Domain	Leu-rich_rpt	PODNL1 LRRC75B LRRC10B LRRC26 FBXL19	4.68e-03	271	75	5	IPR001611
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	SPTBN4 SPTBN5 CACNA1I CACNA1H CACNA1G	3.35e-06	63	52	5	M11187
Pathway	REACTOME_SMOOTH_MUSCLE_CONTRACTION	TRIM72 CACNA1I CACNA1H CACNA1G	1.83e-05	43	52	4	M1429
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	TBXA2R CACNA1I CACNA1H CACNA1G GNAS ADCY3	4.68e-05	178	52	6	M2890
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1I CACNA1H CACNA1G	7.96e-05	23	52	3	M47666
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1I CACNA1H CACNA1G	1.03e-04	25	52	3	M47948
Pathway	WP_PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM_IN_SENESCENCE_WP5122	GNAS PTGIS ADCY3	1.98e-04	31	52	3	M42531
Pathway	WP_PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM_IN_SENESCENCE_WP5321	GNAS PTGIS ADCY3	2.61e-04	34	52	3	M48061
Pathway	REACTOME_NCAM1_INTERACTIONS	CACNA1I CACNA1H CACNA1G	4.91e-04	42	52	3	M7169
Pathway	KEGG_MEDICUS_REFERENCE_AVP_V2R_PKA_SIGNALING_PATHWAY	GNAS ADCY3	5.89e-04	10	52	2	M47648
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTBN4 SPTBN5	5.89e-04	10	52	2	MM15112
Pathway	REACTOME_EICOSANOIDS	CYP4F8 PTGIS	8.60e-04	12	52	2	M27129
Pathway	REACTOME_EICOSANOIDS	CYP4F8 PTGIS	8.60e-04	12	52	2	MM14845
Pubmed	Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.	CACNA1I CACNA1H CACNA1G	1.17e-08	3	80	3	23488970
Pubmed	T-type channels: release a brake, engage a gear.	CACNA1I CACNA1H CACNA1G	1.17e-08	3	80	3	26488564
Pubmed	Differential interactions of Na+ channel toxins with T-type Ca2+ channels.	CACNA1I CACNA1H CACNA1G	1.17e-08	3	80	3	18591418
Pubmed	Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.	CACNA1I CACNA1H CACNA1G	1.17e-08	3	80	3	11230107
Pubmed	Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	CACNA1I CACNA1H CACNA1G	1.17e-08	3	80	3	11897840
Pubmed	Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.	CACNA1I CACNA1H CACNA1G	1.17e-08	3	80	3	28846697
Pubmed	Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.	CACNA1I CACNA1H CACNA1G	1.17e-08	3	80	3	33547341
Pubmed	Calmodulin regulates Cav3 T-type channels at their gating brake.	CACNA1I CACNA1H CACNA1G	1.17e-08	3	80	3	28972185
Pubmed	Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.	CACNA1I CACNA1H CACNA1G	1.17e-08	3	80	3	11927664
Pubmed	Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.	CACNA1I CACNA1H CACNA1G	4.68e-08	4	80	3	28165634
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1I CACNA1H CACNA1G	6.51e-07	8	80	3	28330839
Pubmed	Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.	CACNA1I CACNA1H CACNA1G	6.51e-07	8	80	3	34478646
Pubmed	Intracellular calcium plays an essential role in cardiac development.	CACNA1I CACNA1H CACNA1G	6.51e-07	8	80	3	12761855
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1I CACNA1H CACNA1G	9.75e-07	9	80	3	16382099
Pubmed	Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.	CACNA1I CACNA1H CACNA1G	1.39e-06	10	80	3	24778262
Pubmed	Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL-1 atrial myocytes.	TRPM4 PIEZO1	5.23e-06	2	80	2	38098265
Pubmed	Glycogenic activity of R6, a protein phosphatase 1 regulatory subunit, is modulated by the laforin-malin complex.	PPP1R3D EPM2A	5.23e-06	2	80	2	23624058
Pubmed	Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles.	CACNA1H CACNA1G	5.23e-06	2	80	2	23436820
Pubmed	A T-type calcium channel required for normal function of a mammalian mechanoreceptor.	CACNA1I CACNA1H	5.23e-06	2	80	2	12808460
Pubmed	Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period.	CACNA1H CACNA1G	5.23e-06	2	80	2	14988077
Pubmed	Different distribution of Cav3.2 and Cav3.1 transcripts encoding T-type Ca(2+) channels in the embryonic heart of mice.	CACNA1H CACNA1G	5.23e-06	2	80	2	21079360
Pubmed	Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice.	CACNA1H CACNA1G	5.23e-06	2	80	2	21622683
Pubmed	Deficiency of T-type Ca2+ channels Cav3.1 and Cav3.2 has no effect on angiotensin II-induced hypertension but differential effect on plasma aldosterone in mice.	CACNA1H CACNA1G	5.23e-06	2	80	2	31042060
Pubmed	Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.	CACNA1I CACNA1H	5.23e-06	2	80	2	25071191
Pubmed	The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.	CACNA1H CACNA1G	5.23e-06	2	80	2	22886848
Pubmed	Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.	CACNA1H CACNA1G	5.23e-06	2	80	2	20685979
Pubmed	Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes.	CACNA1I CACNA1H	5.23e-06	2	80	2	36786913
Pubmed	Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice.	CACNA1H CACNA1G	5.23e-06	2	80	2	29082441
Pubmed	[Decreased mRNA expressions of T-type channel alpha1H and alpha1G in the sperm of varicocele patients and their implication].	CACNA1H CACNA1G	5.23e-06	2	80	2	22574369
Pubmed	Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses.	CACNA1I CACNA1G	5.23e-06	2	80	2	26627919
Pubmed	Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.	CACNA1H CACNA1G	5.23e-06	2	80	2	21438841
Pubmed	T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells.	CACNA1H CACNA1G	5.23e-06	2	80	2	22469755
Pubmed	β-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A.	CACNA1H CACNA1G	5.23e-06	2	80	2	22808078
Pubmed	5,6-EET potently inhibits T-type calcium channels: implication in the regulation of the vascular tone.	CACNA1H CACNA1G	1.57e-05	3	80	2	24327205
Pubmed	Ppp1r3d deficiency preferentially inhibits neuronal and cardiac Lafora body formation in a mouse model of the fatal epilepsy Lafora disease.	PPP1R3D EPM2A	1.57e-05	3	80	2	32892347
Pubmed	Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse.	TBXA2R PTGIS	1.57e-05	3	80	2	18514659
Pubmed	Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo.	CACNA1H CACNA1G	1.57e-05	3	80	2	24966091
Pubmed	Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels.	CACNA1I CACNA1G	1.57e-05	3	80	2	27353765
Pubmed	T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions.	CACNA1H CACNA1G	1.57e-05	3	80	2	31919478
Pubmed	Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria.	CACNA1H CACNA1G	1.57e-05	3	80	2	25825486
Pubmed	Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels.	CACNA1H CACNA1G	1.57e-05	3	80	2	21084288
Pubmed	Electric field stimulation unmasks a subtle role for T-type calcium channels in regulating lymphatic contraction.	CACNA1H CACNA1G	1.57e-05	3	80	2	37739992
Pubmed	Global genetic deletion of CaV3.3 channels facilitates anaesthetic induction and enhances isoflurane-sparing effects of T-type calcium channel blockers.	CACNA1I CACNA1G	1.57e-05	3	80	2	33299036
Pubmed	ZnT-1 enhances the activity and surface expression of T-type calcium channels through activation of Ras-ERK signaling.	CACNA1H CACNA1G	1.57e-05	3	80	2	22572848
Pubmed	Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.	CACNA1H CACNA1G	3.13e-05	4	80	2	31800012
Pubmed	Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.	CACNA1H CACNA1G	3.13e-05	4	80	2	21788606
Pubmed	Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons.	GNAS ADCY3	3.13e-05	4	80	2	24034253
Pubmed	A novel EPM2A mutation yields a slow progression form of Lafora disease.	PPP1R3D EPM2A	3.13e-05	4	80	2	30041081
Pubmed	T-type Ca2+ channels elicit pro-proliferative and anti-apoptotic responses through impaired PP2A/Akt1 signaling in PASMCs from patients with pulmonary arterial hypertension.	CACNA1H CACNA1G	3.13e-05	4	80	2	28655554
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CCDC142 TRPM4 LPAR5 MROH6 IL17RE PIEZO1 CACNA1H NLGN2 HERC2 FBXL19 ANKRD33B	4.48e-05	1105	80	11	35748872
Pubmed	Developmental expression patterns of alpha1H T-type Ca2+ channels during spermatogenesis and organogenesis in mice.	CACNA1H CACNA1G	5.20e-05	5	80	2	12060068
Pubmed	T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B.	CACNA1H CACNA1G	5.20e-05	5	80	2	29720258
Pubmed	Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure.	PIEZO1 GNAS	5.20e-05	5	80	2	31205027
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1H CACNA1G	1.09e-04	7	80	2	12900400
Pubmed	Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.	GNAS ADCY3	1.86e-04	9	80	2	9417641
Pubmed	Real-time monitoring of receptor and G-protein interactions in living cells.	TBXA2R GNAS	2.84e-04	11	80	2	15782186
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	PRAMEF7 ZSCAN5A PRAMEF8	3.30e-04	58	80	3	31598710
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTBN4 SPTBN5	4.01e-04	13	80	2	18796539
Pubmed	Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers.	SPTBN4 PRX	6.14e-04	16	80	2	21745462
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	TBXA2R FAM210B PTGIS DNMT3B	6.53e-04	170	80	4	19064572
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF7 PRAMEF8	6.95e-04	17	80	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF7 PRAMEF8	6.95e-04	17	80	2	37781892
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	CACNA1H CACNA1G	6.95e-04	17	80	2	27725084
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF7 PRAMEF8	7.81e-04	18	80	2	29731491
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF7 PRAMEF8	7.81e-04	18	80	2	23894331
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTBN4 SPTBN5	7.81e-04	18	80	2	12119179
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF7 PRAMEF8	7.81e-04	18	80	2	14675769
Pubmed	PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.	CCNF FBXL19	7.81e-04	18	80	2	28614300
Pubmed	Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.	CACNA1G NLGN2	7.81e-04	18	80	2	31910261
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF7 PRAMEF8	7.81e-04	18	80	2	12890732
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF7 PRAMEF8	7.81e-04	18	80	2	39181896
Pubmed	Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.	IL17RE GNAS	8.71e-04	19	80	2	20459687
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF7 PRAMEF8	8.71e-04	19	80	2	28604677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF7 PRAMEF8	9.66e-04	20	80	2	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF7 PRAMEF8	9.66e-04	20	80	2	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF7 PRAMEF8	9.66e-04	20	80	2	21425410
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	TRPM4 GPAA1 OBSL1 CACNA1H UQCRC1 GNAS HERC2	1.13e-03	697	80	7	28298427
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF7 PRAMEF8	1.17e-03	22	80	2	31729367
Pubmed	Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.	UQCRC1 GNAS	1.17e-03	22	80	2	15242332
Pubmed	The sequence and analysis of duplication-rich human chromosome 16.	TRIM72 CACNA1H SLC22A31	1.19e-03	90	80	3	15616553
Pubmed	The DNA sequence and comparative analysis of human chromosome 20.	PPP1R3D FAM210B CPXM1 GNAS PTGIS DNMT3B	1.24e-03	517	80	6	11780052
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF7 PRAMEF8	1.28e-03	23	80	2	19480014
Pubmed	The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.	FAM210B SEMA5A CDH10	1.35e-03	94	80	3	23431145
Pubmed	Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice.	CDH10 MPP7	1.40e-03	24	80	2	26178733
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	SPTBN4 SPTBN5	1.51e-03	25	80	2	8493579
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF7 PRAMEF8	1.51e-03	25	80	2	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF7 PRAMEF8	1.51e-03	25	80	2	12620990
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF7 PRAMEF8	1.64e-03	26	80	2	18500982
Pubmed	Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring.	SEMA5A CDH10	1.64e-03	26	80	2	39152101
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ARHGAP23 NLGN2 KANK2	1.76e-03	103	80	3	10819331
Pubmed	Rex1/Zfp42 as an epigenetic regulator for genomic imprinting.	GNAS DNMT3B	1.77e-03	27	80	2	21233130
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF7 PRAMEF8	1.90e-03	28	80	2	25089626
Pubmed	Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.	TMEM160 ADCY3	1.90e-03	28	80	2	24861553
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	AARS2 DYRK1B PTGIS RGS3	2.08e-03	233	80	4	37704626
Pubmed	TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer.	ASB10 GNAS	2.18e-03	30	80	2	34285210
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF7 PRAMEF8	2.18e-03	30	80	2	38786026
Cytoband	16q24.3	PIEZO1 CDT1 SLC22A31	1.06e-04	52	80	3	16q24.3
Cytoband	20q13.3	PPP1R3D GNAS	5.58e-04	20	80	2	20q13.3
Cytoband	5p15.2	SEMA5A ANKRD33B	1.02e-03	27	80	2	5p15.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16q24	PIEZO1 CDT1 SLC22A31	1.77e-03	136	80	3	chr16q24
GeneFamily	Calcium voltage-gated channel subunits	CACNA1I CACNA1H CACNA1G	6.59e-05	26	55	3	253
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN4 SPTBN5	1.89e-04	7	55	2	1113
GeneFamily	PDZ domain containing	ARHGAP23 RGS3 PRX MPP7	1.17e-03	152	55	4	1220
GeneFamily	PRAME family	PRAMEF7 PRAMEF8	2.40e-03	24	55	2	686
GeneFamily	Ankyrin repeat domain containing	ASB10 KANK2 ANKRD33B KRIT1	6.26e-03	242	55	4	403
ToppCell	Endothelial-G\|World / shred on cell class and cell subclass (v4)	MROH6 DTX1 GNAS TMEM200B MPP7	2.99e-06	124	80	5	4b72809463f2986b7d1b7ab9de633ac4d7854a92
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Acta2Rgs5.Fos_(Mural.Acta2Rgs5.Fos)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	LRRC10B PTGIS PRX TMEM200B DNMT3B	4.87e-06	137	80	5	5ca712230a888403769547c2e03760131abaa4cf
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Acta2Rgs5.Fos_(Mural.Acta2Rgs5.Fos)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	LRRC10B PTGIS PRX TMEM200B DNMT3B	4.87e-06	137	80	5	2282caba7a59d7c0d7a3de8b04a94a24fa01d10c
ToppCell	BL-critical-LOC-Epithelial-FOXN4+\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LRRC26 SEMA5A CDT1 KANK2 TMEM200B	1.04e-05	160	80	5	3f737451d5713deed20061aa72a9ef77a9a2bc06
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|World / disease group, cell group and cell class (v2)	TRPM4 EPM2A LRRC26 ANKRD33B GASK1A	1.27e-05	167	80	5	bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PODNL1 LRRC75B RASAL3 IL17RE CDH10	1.51e-05	173	80	5	0a355386210a13927ea29b10b64cb059459952d4
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-immature_innate_lymphoid_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PODNL1 LRRC75B RASAL3 IL17RE CDH10	1.51e-05	173	80	5	3678b300cad4effd7f49bfb043305ed512693848
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 LRRC75B RASAL3 IL17RE CDH10	1.55e-05	174	80	5	aae7ab9df5a78716034ddfd5bd47adc69912d624
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 LRRC75B RASAL3 IL17RE CDH10	1.55e-05	174	80	5	d9489c4196d103ead8cb6279492bbe563a222e45
ToppCell	facs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB PIEZO1 CPXM1 ANKRD33B PTGIS	1.83e-05	180	80	5	12537d8a569faa69f474284d2c201475722b8ca1
ToppCell	10x5'-bone_marrow-Lymphocytic_B-Pre-B\|bone_marrow / Manually curated celltypes from each tissue	DTX1 LRRC26 KANK2 ANKRD33B DNMT3B	1.93e-05	182	80	5	a5fd392178c2f533e265d2e3ce63b90c2553e4c1
ToppCell	Hippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Ccnd1_(Mural.Rgs5Acta2.Ccnd1)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TRIM72 TBXA2R ASB10 TMEM200B	1.93e-05	88	80	4	5fdfc72988dcbb7d2025866b2b00eab8f11f332f
ToppCell	Hippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Ccnd1_(Mural.Rgs5Acta2.Ccnd1)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TRIM72 TBXA2R ASB10 TMEM200B	1.93e-05	88	80	4	b9874366925fa1c08a74b14c3c6e127b9dffa23e
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRIM72 TBXA2R PTPRB DTX1 DNMT3B	2.09e-05	185	80	5	59acaf025353405948dc34ccccf37ec5c08ea903
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CCDC142 AARS2 RINL PTGIS PRX	2.09e-05	185	80	5	daea170d827226dda6750bf1838ffd82f070c4d4
ToppCell	droplet-Fat-Gat-18m-Lymphocytic-T_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 IL17RE RINL CDH10	2.14e-05	186	80	5	2c1166777b31b802bf88a77acc2838a33c801e76
ToppCell	(1)_Osterolineage_cells-(10)_OLC-1\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	PODNL1 CPXM1 SEMA5A PTGIS RGS3	2.31e-05	189	80	5	46c5b975fb9d33017f2d9b7770d45a8bdf95baa2
ToppCell	NS-critical-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LRRC26 SEMA5A CDT1 KANK2 TMEM200B	2.37e-05	190	80	5	7be0f2ff86ca8500a43e0d44e5e292530f9ba0bb
ToppCell	NS-moderate-d_16-33-Epithelial-FOXN4+\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LRRC26 SEMA5A CDT1 KANK2 TMEM200B	2.37e-05	190	80	5	250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASB10 LRRC10B CACNA1H KANK2 ADCY3	2.55e-05	193	80	5	7631bf3362b4fa061ffeab4879ab12c4708dc4c0
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASB10 LRRC10B CACNA1H KANK2 ADCY3	2.55e-05	193	80	5	8d15c63f2ae48d0a00d7ef5fdafa917ab8ad0571
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	ARHGAP23 NLGN2 ANKRD33B ADCY3 TMEM200B	2.68e-05	195	80	5	5562665dd3beb70e2358aa32611a337bef5731c1
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CCDC142 CCNF PPP1R3D AARS2 CPXM1	2.68e-05	195	80	5	5812b1615676f3b77eb4769216b98b360c417c0d
ToppCell	Caecum-(1)_T_cell-(18)_cycling_gd_T\|Caecum / shred on region, Cell_type, and subtype	CCNF LRRC26 STYK1 CDT1 PRX	2.89e-05	198	80	5	64278d8831c81874937e76b561c53928dfc437c5
ToppCell	critical-Epithelial-FOXN4+\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LRRC26 SEMA5A CDT1 KANK2 TMEM200B	2.89e-05	198	80	5	6b160b3d6a2c1b1641c2c7dcec1a7ef38411fec9
ToppCell	Caecum-T_cell-cycling_gd_T\|Caecum / Region, Cell class and subclass	CCNF LRRC26 STYK1 CDT1 PRX	2.89e-05	198	80	5	5b719b67f8384863077070e1eb7e04a320e6dab4
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CPXM1 KANK2 PTGIS TMEM200B GASK1A	2.96e-05	199	80	5	21335475bbfbad8a6943b8076a6c1c67f3eec5d3
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-4\|TCGA-Brain / Sample_Type by Project: Shred V9	TRIM72 PNMA6F NEURL1 STYK1	9.98e-05	134	80	4	04ee54e788f6659af0349be8c0ff991fcac2b2aa
ToppCell	Lymphoid-T_cells_(Cd8+_T_cell)\|World / shred on cell class and cell subclass (v4)	PODNL1 RASAL3 DTX1 RINL	1.15e-04	139	80	4	c85f50fb536f4df6fa4dbdebe48e1ecea1df1121
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-MyoFB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	NEURL1 OBSL1 CACNA1G TMEM200B	1.22e-04	141	80	4	7ae8ead02e5aeb4106c4a30c08a7a061da3a5d6a
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	EPM2A CACNA1G CLUH PRX	1.32e-04	144	80	4	5e948d4cb913ccd8f82262a1b4d20967aadab3ab
ToppCell	facs-Marrow-KLS-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB STYK1 PTGIS PRX	1.71e-04	154	80	4	37765512dfae557b9f6eb30a29463b93682a4404
ToppCell	droplet-Liver-Hepatocytes-24m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 DTX1 STYK1	1.84e-04	157	80	4	cbb08d5c151f0622123276926a2a15bb7d271e90
ToppCell	droplet-Liver-Hepatocytes-24m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 DTX1 STYK1	1.84e-04	157	80	4	16581e2399a211633f870dce326c75ff4b6a5fe6
ToppCell	Adult-Immune-mast_cell-D175\|Adult / Lineage, Cell type, age group and donor	DTX1 NEURL1 RUNDC1 RGS3	1.93e-04	159	80	4	9f53fe2e0f25448d62a591c8e528e9a49b5400d5
ToppCell	PND01-03-samps\|World / Age Group, Lineage, Cell class and subclass	PTPRB ANKRD33B PTGIS PRX	2.02e-04	161	80	4	1973b112d8d67aacc02751797d0148e7b53bfa66
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Pre-B\|bone_marrow / Manually curated celltypes from each tissue	LRRC75B ARHGAP23 DTX1 DNMT3B	2.07e-04	162	80	4	e088e66aabc307dde5d2b9aa295c34ef68155b1a
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TRIM72 DYRK1B CDT1 KANK2	2.07e-04	162	80	4	ca30d9bf61f4133566fdc91c7996e130ea554d01
ToppCell	343B-Fibroblasts-Fibroblast-D-\|343B / Donor, Lineage, Cell class and subclass (all cells)	CPXM1 NLGN2 FBXL19 PTGIS	2.12e-04	163	80	4	8d2b2119c6b3d5b677da6f377fd85146590e1246
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CCNF RASAL3 CDT1 GASK1A	2.12e-04	163	80	4	360cd65decda24853124f33a174f5224d7f3ce23
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CCNF RASAL3 CDT1 GASK1A	2.12e-04	163	80	4	b59d9b4f7c9f4e5e2c7783a49a96729dae3a81e5
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCNF PTPRB SHF CDT1	2.12e-04	163	80	4	3efbbdc9cb2613bb76d8c2f07cd4ec1a2c51a622
ToppCell	343B-Fibroblasts-Fibroblast-D\|343B / Donor, Lineage, Cell class and subclass (all cells)	CPXM1 NLGN2 FBXL19 PTGIS	2.12e-04	163	80	4	acfb2ece6202479e615d54fd3ecb8b4a571b5a18
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCNF STYK1 RINL GASK1A	2.17e-04	164	80	4	ae09e5aabd1347b865474255e7411c04f63efb3b
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TBXA2R PODNL1 CDT1 PRX	2.17e-04	164	80	4	1592a5becad7e0f3f990f0d7581d75fcfc7da023
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NHSL2 PTGIS ADCY3 NENF	2.22e-04	165	80	4	4e13fccd32029e2879e85f8966e582a46c09e4aa
ToppCell	facs-Spleen-nan-18m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNF ARHGAP23 ASB10 CACNA1G	2.27e-04	166	80	4	8d535fab019356894b4dad3fbdbc4d2ad3e16082
ToppCell	facs-Spleen-nan-18m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNF ARHGAP23 ASB10 CACNA1G	2.27e-04	166	80	4	f56b1c0d6cb5353a16a2598bda905287f16d2c39
ToppCell	facs-Heart-RV-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 STYK1 CDH10	2.27e-04	166	80	4	c0fd3f3f5c3412746da279b856af0d28b9b70c5d
ToppCell	facs-Heart-RV-3m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 STYK1 CDH10	2.27e-04	166	80	4	33c4876df43b4c1d100699bca47459918bd054d6
ToppCell	facs-Heart-RV-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 STYK1 CDH10	2.27e-04	166	80	4	ac9b9df57d65ccbbf9ae3add50c5663efcd30dcb
ToppCell	facs-Spleen-nan-18m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNF ARHGAP23 ASB10 CACNA1G	2.27e-04	166	80	4	a5074c96c6561273029aceb93402a7e038140f50
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_pDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	IL17RE LRRC26 CPXM1 DNMT3B	2.32e-04	167	80	4	8ddf9da71a7c4ed53588435db826563a24cee616
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-immature_innate_lymphoid_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PODNL1 RASAL3 IL17RE RINL	2.32e-04	167	80	4	5d1919bea8e5a52ac6fc953caff15509b7142923
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PODNL1 RASAL3 IL17RE RINL	2.32e-04	167	80	4	d8f497860d48342a3aaaad328f88e4d55ab4faeb
ToppCell	facs-Heart-LV-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 DTX1 RINL	2.38e-04	168	80	4	18c266162a879544c0103d9dff0270af68964f9e
ToppCell	facs-Liver-Non-hepatocytes-24m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 STYK1 RINL	2.38e-04	168	80	4	1254c66f0cd53ef3b913933c0b0648d091da07e9
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PODNL1 RASAL3 DTX1 RINL	2.38e-04	168	80	4	6c758eb120faf06ff72d157b495e399191c79ec9
ToppCell	facs-MAT-Fat-24m-Lymphocytic-T_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN4 PODNL1 IL17RE CDH10	2.38e-04	168	80	4	22fa707689e8d6ca5154103b7374007d644d61c3
ToppCell	facs-Heart-LV-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 DTX1 RINL	2.38e-04	168	80	4	cb1506cd43a4f36f9024cc9b8e5319365498d244
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 DTX1 RINL	2.43e-04	169	80	4	18ba8fc2ba8838484d3b223428cd41568e2ccb10
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB IL17RE PRX GASK1A	2.43e-04	169	80	4	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	droplet-Lung-nan-21m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 DTX1 RINL	2.43e-04	169	80	4	47a63afd80cb7ba2258ba57d3084d8b2a7bc4e8d
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NLGN2 FBXL19 RUNDC1 TMEM200B	2.49e-04	170	80	4	330b5fc8fde307eda9dcc7bc9053ea8a7e1f0f6d
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NLGN2 FBXL19 RUNDC1 TMEM200B	2.49e-04	170	80	4	0c9d38e89b048166b879e6b4bdf7c5dfe8ab57c4
ToppCell	10x5'-Lung-Lymphocytic_T_CD8-Trm_gut_CD8\|Lung / Manually curated celltypes from each tissue	LPAR5 DNLZ STYK1 SEMA5A	2.54e-04	171	80	4	c8ccb7795ce8321739e3bc07db2ffc183d04e660
ToppCell	droplet-Liver-nan-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3D IL17RE SEMA5A PTGIS	2.60e-04	172	80	4	f814b6134ad608015765399d54cc1e5e1873ed34
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 LRRC75B RASAL3 DTX1	2.60e-04	172	80	4	f45489e80c59b824846ffda675de0d118a8b850c
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PODNL1 RASAL3 IL17RE DTX1	2.60e-04	172	80	4	30f4979abf0218618a56afb06aa6afc23ad838ec
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CCNF STYK1 SEMA5A CDT1	2.66e-04	173	80	4	20889aa85e36ad3bafdb91b91e43964493c949f9
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB ASB10 CACNA1H RGS3	2.66e-04	173	80	4	a2c1ef3f4d7e9f68fc77ee7c42a4727bdea5da94
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB ASB10 CACNA1H RGS3	2.66e-04	173	80	4	4830136f1f1976e00ac9af9062a531ac42533041
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB ASB10 CACNA1H RGS3	2.66e-04	173	80	4	0b79e2a4fd19d524c24b69a6b524ffc6affdabe5
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CCNF STYK1 SEMA5A CDT1	2.66e-04	173	80	4	46e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	PTPRB ANKRD33B RGS3 PRX	2.72e-04	174	80	4	b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-CD8+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 DTX1 RINL	2.72e-04	174	80	4	986e591d3d46009e53548dfa1f2126cf31063ef4
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 CDT1 RINL	2.72e-04	174	80	4	ecee7e012ccd7876fb9df8aa939f8eb05b0c2b13
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 CDT1 RINL	2.72e-04	174	80	4	693fc31bed0f560644e419fa70ef09f863425416
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-Alox5+_Lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN4 RASAL3 LPAR5 RUNDC1	2.72e-04	174	80	4	a8bd1fa08bf061a627529a38e5a23a68b6d80697
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN4 RASAL3 LPAR5 RUNDC1	2.72e-04	174	80	4	7f8f6a15a823809effd37c1a5b09ef19b6d67755
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPTBN4 NEURL1 ADCY3 CDH10	2.72e-04	174	80	4	7fb7bdf62563f2102fb38618b503eb2817b6594f
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCNF PPP1R3D PTPRB CDT1	2.72e-04	174	80	4	6c36d607c48267a75ab4da6fb2fe3f931d1b3b52
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 DTX1 RINL	2.72e-04	174	80	4	785be49a2dbbb1dff0fbced1b48b942c2f4a508d
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PODNL1 RASAL3 DTX1 RINL	2.72e-04	174	80	4	7c8cc5c2872fc7bcca7ebddaf5a6f20e617a2674
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 DTX1 RINL	2.78e-04	175	80	4	a72c6ceca5ddbd34f652e7302defefa2d105e17e
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	CCNF LRRC26 STYK1 CDT1	2.78e-04	175	80	4	fd8b5b756f3df4a04938785f3d9edbb6f1cd20f6
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD8+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 DTX1 RINL	2.78e-04	175	80	4	9a462e9e6f7bbb64abb09ad6c080df3576073540
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|368C / Donor, Lineage, Cell class and subclass (all cells)	CCNF LRRC26 STYK1 CDT1	2.78e-04	175	80	4	36c140540497bbe1c5f08fac2d94f08cac18fabb
ToppCell	facs-Trachea-nan-18m-Lymphocytic-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 RINL CDH10	2.84e-04	176	80	4	14c6c3fdb53f9dfc02b951bc955b90213110c089
ToppCell	Entopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	TBXA2R ASB10 LRRC10B TMEM200B	2.84e-04	176	80	4	10c1f31c27e54b70f58f0b0086ac74dee2ce4197
ToppCell	facs-Trachea-nan-18m-Lymphocytic\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 RINL CDH10	2.84e-04	176	80	4	9dd862dcee6947a53189728f6b4cd40e7b67cb71
ToppCell	Entopeduncular-Endothelial-MURAL\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	TBXA2R ASB10 LRRC10B TMEM200B	2.84e-04	176	80	4	b8e52bec78876562a25f0b0de502aa9372b28bd2
ToppCell	facs-Trachea-nan-18m-Lymphocytic-T_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 RINL CDH10	2.84e-04	176	80	4	d990e7af8120210100d13caa0465b27cf77a451a
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Lymphocytic-T_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 LRRC75B RASAL3 RINL	2.90e-04	177	80	4	9d2d70d53b919fed3328812889a55e5e1a0759de
ToppCell	facs-SCAT-Fat-18m-Lymphocytic-NK_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 IL17RE DTX1 CDH10	2.90e-04	177	80	4	be35bb178fbc149f8a12984c012d98b486325ba9
ToppCell	facs-Heart-LA-18m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 IL17RE RINL	2.96e-04	178	80	4	b4b4e021e86d1d523fa40695cb0a91021dee27d1
ToppCell	facs-Heart-LA-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 IL17RE RINL	2.96e-04	178	80	4	d32b4e9c3d1f246ad49e2d8f6497989af68a6c00
ToppCell	facs-Liver-Non-hepatocytes-24m-Lymphocytic-mature_NK_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 RASAL3 DTX1 RINL	2.96e-04	178	80	4	291ffc52b824e4f59078147eb640ef34e24fb450
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF151 NEURL1 ANKRD33B CDH10	2.96e-04	178	80	4	09a215a0d6e98e4bb920cabda12af08ff4de3c98
ToppCell	droplet-Liver-Hepatocytes-21m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASAL3 DTX1 LRRC26 CACNA1I	2.96e-04	178	80	4	4289e435d465b7a1490d13bf05278f4ed77d69cd
Drug	1,3-dioxoisoindoline-5-carboxamide	CACNA1I CACNA1H CACNA1G	4.02e-08	3	79	3	CID010679219
Drug	Flunarizine	CACNA1I CACNA1H CACNA1G	4.00e-07	5	79	3	DB04841
Drug	Chenodiol [474-25-9]; Up 200; 10.2uM; HL60; HT_HG-U133A	PPP1R3D CYP4F8 FAM210B NEURL1 DYRK1B OBSL1 CACNA1I RGS3	4.37e-07	198	79	8	2402_UP
Drug	AC1L1DXN	TBXA2R CYP4F8 LPAR5 CTF1 PTGIS ADCY3	5.42e-07	86	79	6	CID000002552
Drug	3,4-dihydroquinazoline	CACNA1I CACNA1H CACNA1G	7.98e-07	6	79	3	CID000583065
Drug	LY215840	CACNA1I CACNA1H CACNA1G	1.39e-06	7	79	3	CID000132049
Drug	Cinnarizine	CACNA1I CACNA1H CACNA1G	3.33e-06	9	79	3	DB00568
Drug	Mibefradil	CACNA1I CACNA1H CACNA1G	6.50e-06	11	79	3	DB01388
Drug	EBNs	CACNA1I CACNA1H CACNA1G	6.50e-06	11	79	3	CID000150695
Drug	SQ22536	TBXA2R CACNA1I CACNA1H CACNA1G GNAS ADCY3	7.58e-06	135	79	6	CID000005270
Drug	lanthanum	TRPM4 CACNA1I CACNA1H CACNA1G ADCY3 KRIT1	7.90e-06	136	79	6	CID000023926
Drug	AC1L2VU3	CACNA1I CACNA1H CACNA1G	8.65e-06	12	79	3	CID000129572
Drug	themisone	CACNA1I CACNA1H CACNA1G	8.65e-06	12	79	3	CID000016235
Drug	tetralol	CACNA1I CACNA1H CACNA1G	1.12e-05	13	79	3	CID000010747
Drug	Mibefradil	CACNA1I CACNA1H CACNA1G	1.12e-05	13	79	3	ctd:D020748
Drug	AC1L1KS5	TBXA2R LPAR5 CACNA1I CACNA1H CACNA1G GNAS ADCY3 KRIT1	2.08e-05	334	79	8	CID000005631
Drug	pentasulfane	CACNA1I CACNA1H CACNA1G	2.18e-05	16	79	3	CID000448216
Drug	Zonisamide	CACNA1I CACNA1H CACNA1G	2.64e-05	17	79	3	DB00909
Drug	SureCN2398996	CACNA1I CACNA1H	3.56e-05	3	79	2	CID010220069
Drug	N-desmethylmethsuximide	CACNA1I CACNA1H	3.56e-05	3	79	2	CID000092154
Drug	cyclopropanecarboxylic acid	CACNA1I CACNA1H CACNA1G	3.74e-05	19	79	3	CID000015655
Drug	AC1MUNZL	TBXA2R CYP4F8 PTGIS ADCY3	4.30e-05	56	79	4	CID003643892
Drug	AC1L1AL2	TBXA2R SPTBN5 CYP4F8 PTGIS ADCY3	5.04e-05	115	79	5	CID000001035
Drug	Thioguanosine [85-31-4]; Down 200; 12.6uM; MCF7; HT_HG-U133A	CCNF TNK1 FAM210B KANK2 RGS3 KRIT1	5.23e-05	190	79	6	2619_DN
Drug	U46619	TBXA2R CYP4F8 CACNA1I CACNA1H CACNA1G PTGIS ADCY3	6.01e-05	285	79	7	CID000005618
Drug	Retrorsine [480-54-6]; Up 200; 11.4uM; PC3; HT_HG-U133A	SPTBN5 PODNL1 EPM2A PTPRB CACNA1G CDH10	6.22e-05	196	79	6	6601_UP
Drug	Flunarizine dihydrochloride [30484-77-6]; Up 200; 8.4uM; HL60; HT_HG-U133A	SPTBN4 PPP1R3D AMN FAM210B NEURL1 ADGRD2	6.22e-05	196	79	6	2381_UP
Drug	Lisinopril [83915-83-7]; Up 200; 9uM; HL60; HT_HG-U133A	TBXA2R AMN FAM210B DYRK1B RGS3 PRX	6.40e-05	197	79	6	2371_UP
Drug	0225151-0000 [351320-15-5]; Up 200; 10uM; PC3; HT_HG-U133A	TBXA2R TNK1 EPM2A FAM210B SEMA5A PRX	6.40e-05	197	79	6	6389_UP
Drug	Cinchonine [118-10-5]; Up 200; 13.6uM; PC3; HT_HG-U133A	TBXA2R PPP1R3D PTPRB NEURL1 SEMA5A KRIT1	6.40e-05	197	79	6	3988_UP
Drug	Flunixin meglumine [42461-84-7]; Up 200; 8.2uM; PC3; HT_HG-U133A	SPTBN5 NEURL1 DYRK1B CACNA1I ADGRD2 PTGIS	6.58e-05	198	79	6	4273_UP
Drug	Prazosin hydrochloride [19237-84-4]; Up 200; 9.6uM; MCF7; HT_HG-U133A	TBXA2R EPM2A NEURL1 CACNA1I GNAS PRX	6.58e-05	198	79	6	5416_UP
Drug	valdecoxib; Up 200; 10uM; PC3; HT_HG-U133A	TBXA2R SPTBN5 PPP1R3D TRPM4 CACNA1I RGS3	6.95e-05	200	79	6	6408_UP
Drug	methsuximide	CACNA1I CACNA1H	7.10e-05	4	79	2	CID000006476
Drug	7-oxabicyclo[2.2.1]heptane	TBXA2R PTGIS	7.10e-05	4	79	2	CID000009234
Drug	AC1L1TJF	CACNA1I CACNA1H CACNA1G ADCY3	8.22e-05	66	79	4	CID000003377
Drug	hydroxamates	CACNA1I CACNA1H CACNA1G	8.75e-05	25	79	3	CID000033630
Drug	cicaprost	TBXA2R CTF1 GNAS PTGIS	1.03e-04	70	79	4	CID005311044
Drug	AC1O7G5C	CACNA1I CACNA1H	1.18e-04	5	79	2	CID006603942
Drug	phensuximide	CACNA1I CACNA1H	1.18e-04	5	79	2	CID000006839
Drug	CAS 298-57-7	CACNA1I CACNA1H CACNA1G PTGIS	1.22e-04	73	79	4	CID000002761
Drug	ethosuximide	EPM2A CACNA1I CACNA1H CACNA1G	1.28e-04	74	79	4	CID000003291
Drug	rufinamide	CACNA1I CACNA1H CACNA1G	1.38e-04	29	79	3	CID000129228
Drug	anacardic acid	CACNA1I CACNA1H CACNA1G	1.53e-04	30	79	3	CID000167551
Drug	nisoldipine	TBXA2R CACNA1I CACNA1H CACNA1G	1.58e-04	78	79	4	CID000004499
Drug	AC1MQ5W8	CACNA1I CACNA1H	1.77e-04	6	79	2	CID003396482
Drug	cerebrocrast	CACNA1I CACNA1H	1.77e-04	6	79	2	CID000159556
Drug	Bay K 8644	TBXA2R CACNA1I CACNA1H CACNA1G ADCY3	1.77e-04	150	79	5	CID000002303
Drug	CNS 1145	CACNA1I CACNA1H CACNA1G	2.04e-04	33	79	3	CID000190902
Drug	IHC-64	CACNA1I CACNA1H CACNA1G	2.04e-04	33	79	3	CID000162753
Drug	EP 045	TBXA2R GNAS	2.47e-04	7	79	2	CID009576927
Drug	losigamone	CACNA1I CACNA1H	2.47e-04	7	79	2	CID000060572
Disease	Hemorrhagic Disorders	TBXA2R GNAS	1.76e-05	3	72	2	C0019087
Disease	hemoglobin measurement, mean corpuscular hemoglobin concentration	PIEZO1 CDT1	1.63e-04	8	72	2	EFO_0004509, EFO_0004528
Disease	Sclerocystic Ovaries	SPTBN4 ARHGAP23 ADGRD2 GNAS	4.33e-04	144	72	4	C1136382
Disease	Polycystic Ovary Syndrome	SPTBN4 ARHGAP23 ADGRD2 GNAS	4.33e-04	144	72	4	C0032460
Disease	obsolete_red blood cell distribution width	PRMT6 CCNF LPAR5 ARHGAP23 PIEZO1 ADGRD2 CDT1 KANK2 CLUH SLC22A31	1.55e-03	1347	72	10	EFO_0005192
Disease	suicidal ideation, suicide behaviour	AMN FBXL19	1.57e-03	24	72	2	EFO_0004320, EFO_0007623
Disease	chromatid-type aberration frequency	SEMA5A GNAS	1.84e-03	26	72	2	EFO_0009862
Disease	sciatic neuropathy (biomarker_via_orthology)	CACNA1I CACNA1H NLGN2	1.85e-03	99	72	3	DOID:11446 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PRSRLPIRLLRGLLA	GNAS	471	P84996
RCRRQPRLRLPTDSL	EPM2A	211	B3EWF7
LLAELRAREPARRRR	B3GALT6	166	Q96L58
GITSLRRVPRRRLPS	LINC00242	11	Q5T6M2
RRQAELNPRAPRLLR	CTF1	106	Q16619
AIPAARRRPIRVLSL	DNMT3B	566	Q9UBC3
VLRLLLRRRARPDSA	ASB10	131	Q8WXI3
QARPPARRRLRLSVD	CDT1	61	Q9H211
AKVPPDLRRRLERLR	CPXM1	716	Q96SM3
PLLDALREPRLRRIF	CCDC142	401	Q17RM4
LLVAPPLLRRAGRLR	AMN	376	Q9BXJ7
VRLLPRRLPLAFRDA	DYRK1B	26	Q9Y463
LLPLQRLRRRSVRPG	ANKRD33B	406	A6NCL7
PLFRRCPRLRRLDLR	FBXL19	646	Q6PCT2
RARIRARRLRVLPSE	RASAL3	416	Q86YV0
VARRRLRPLRDPLLR	RGS3	271	P49796
EASPRVRPRRRLLDL	SLC16A8	231	O95907
SLFRRCRRRLIPHPR	CDRT15	21	Q96T59
ARLSVRPRQLRVLRP	OBSL1	1531	O75147
ERPSARLSIRRDRPL	PTPRB	1651	P23467
PLRLRHLRRPRVARL	LPAR5	126	Q9H1C0
DPVRRRALARLVLRL	GPAA1	6	O43292
SLVRRPSARRLERPR	GPR179	881	Q6PRD1
PLLRESTLRRRRVRP	HERC2	2116	O95714
LRDLPRLLRALDARP	IL17RE	616	Q8NFR9
LERRPPDFLRLLRLI	PNMA6F	406	A0A0J9YX94
LLPPRLDARLLRTAR	FAM210B	41	Q96KR6
RRLALRRPEILVQPL	MPP7	296	Q5T2T1
PRRRLRPLAALALVL	NENF	6	Q9UMX5
TLRERRPERARQLLR	LRRC75B	41	Q2VPJ9
RRFPRPLLRLVALQS	LRRC10B	126	A6NIK2
RETPQLFLRRDVRLP	KRIT1	501	O00522
LGALRRLLLRPRAPV	MROH6	461	A6NGR9
RLLLRPRAPVRLLSA	MROH6	466	A6NGR9
PRGLRLRLPRRESLL	C6orf223	161	Q8N319
LRLPRRESLLRGLCR	C6orf223	166	Q8N319
VLLRARRSPALLRTP	UQCRC1	16	P31930
RRRLRRRLDLAYPLT	DTX1	166	Q86Y01
RVPPALPRRLRALVL	PODNL1	351	Q6PEZ8
LVRPIRSRRALPPLR	FAM189A2	256	Q15884
RVLGLRRSLPAVARR	GASK1A	336	Q9UFP1
RLLRTLRPLRVISRA	CACNA1G	1381	O43497
RRIRRRPRNLTILSL	CCNF	21	P41002
RLLSRVQPRAPCLRR	DNLZ	11	Q5SXM8
LRRDIIPETLFIPRR	CDH10	686	Q9Y6N8
LRVLRLLRTLRPLRV	CACNA1I	1271	Q9P0X4
LLRTLRPLRVISRAP	CACNA1I	1276	Q9P0X4
LLRFRILPDHREPRR	CYP4F8	486	P98187
PNPRRRLRLQDLADR	ADCY3	561	O60266
ITLLPSRDNPRRLRV	PRMT6	341	Q96LA8
PPITRRRSSLLRQLL	FAM47A	251	Q5JRC9
RVAVQRRPRLSSLPR	KANK2	61	Q63ZY3
RVLRLLRTLRPLRVI	CACNA1H	1396	O95180
PPRLLELARQRLLRD	PRAMEF8	6	Q5VWM4
DRLRRSPLLRGRPRQ	SLC22A31	521	A6NKX4
RDRRQELRCRRLSPP	NLGN2	701	Q8NFZ4
PGRTLRRLRAERRRL	RUNDC1	76	Q96C34
RQERRRPLLLSLLRR	RNF151	171	Q2KHN1
PPEPLRVRARLRLRS	TMEM200B	36	Q69YZ2
RTVRLRRRLPCRLLG	NHSL2	71	Q5HYW2
LLLLSRRRTRRPGEP	PTGIS	16	Q16647
FLRRLDLPIERQPRK	CTPS1	266	P17812
PPLVLRRILRRAVRF	AARS2	346	Q5JTZ9
RRPRVRDRLPILLQR	SPTBN5	2116	Q9NRC6
FPERRREPIRSLQIL	SEMA5A	451	Q13591
LRRPPQRRARTTAVL	ADGRD2	106	Q7Z7M1
TPTLRLNRFLRAPRL	CNGA4	136	Q8IV77
ELPRKNLPERLLRER	CLUH	366	O75153
READRPSPRELRLRL	STYK1	366	Q6J9G0
RTLRAPELRRLRRRQ	RINL	366	Q6ZS11
PELRRLRRRQTALRA	RINL	371	Q6ZS11
PPRLLELARQRLLRD	PRAMEF7	6	Q5VXH5
TRLRIIRLRDRLEPR	SHF	86	Q7M4L6
IRLRDRLEPRPLAIL	SHF	91	Q7M4L6
LRPRSFTALRRPSLR	NEURL1	226	O76050
VRLRRPLSPETRRRR	ARHGAP23	1386	Q9P227
AAPARRRLQLPRLRV	PRX	181	Q9BXM0
RELQILPRVPALSRR	ZSCAN5A	181	Q9BUG6
DPRLRPIILRRARSL	PPP1R3D	61	O95685
RLVRLLEPLQERRRL	SPTBN4	1496	Q9H254
RALRSPERRPTRIGL	TRIM72	401	Q6ZMU5
RFLLPLERISEVPRR	nan	61	Q5XG85
LILQRLEDRARLPRP	TNK1	331	Q13470
LRPRDTRRISLRFRR	PIEZO1	1861	Q92508
LRRLQPRLSTRPRSL	TBXA2R	316	P21731
ARLARLRFRRSLLPP	TMEM160	11	Q9NX00
RLLLRQLCRRPRSPQ	TRPM4	1086	Q8TD43
RARRRRLRTAALRPP	LRRC26	291	Q2I0M4