Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncAMP-dependent protein kinase activity

PRKACA PRKACG

1.85e-047602GO:0004691
GeneOntologyMolecularFunctioncyclic nucleotide-dependent protein kinase activity

PRKACA PRKACG

3.15e-049602GO:0004690
GeneOntologyMolecularFunctionAMP-activated protein kinase activity

PRKACA PRKACG

3.93e-0410602GO:0004679
GeneOntologyBiologicalProcessprotein-DNA complex organization

ZNF462 HDAC9 GLMN MBTD1 SMCHD1 SUPT16H ERCC6L2 AHR TEX15 IFI16 USP16 HP1BP3

2.12e-059995912GO:0071824
GeneOntologyBiologicalProcesschromatin organization

ZNF462 HDAC9 GLMN MBTD1 SMCHD1 SUPT16H ERCC6L2 TEX15 IFI16 USP16 HP1BP3

4.04e-058965911GO:0006325
DomainTPR-like_helical_dom

APPBP2 SAMD9 TRANK1 WDR35 CSTF3

7.15e-04233575IPR011990
DomainCyclin_N

CABLES2 CCNB1

4.55e-0333572IPR006671
DomainCyclin_N

CABLES2 CCNB1

4.55e-0333572PF00134
DomainCYCLIN

CABLES2 CCNB1

6.00e-0338572SM00385
Domain-

CABLES2 CCNB1

6.63e-03405721.10.472.10
Domain-

SAMD9 TRANK1 MCM8 ERCC6L2 GNAT3 ABCC11 DNAH14

7.35e-037465773.40.50.300
DomainCyclin-like

CABLES2 CCNB1

7.63e-0343572IPR013763
PathwayKEGG_TASTE_TRANSDUCTION

TAS2R13 PRKACA PRKACG GNAT3

2.40e-0552464M5785
PathwayREACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS

PRKACA PRKACG

1.04e-045462M26988
PathwayWP_CANNABINOID_RECEPTOR_SIGNALING

PRKACA PRKACG AHR

1.12e-0429463M39676
PathwayKEGG_MEDICUS_REFERENCE_PKA_HOLOENZYME

PRKACA PRKACG

2.16e-047462M47896
PathwayREACTOME_HDL_ASSEMBLY

PRKACA PRKACG

2.88e-048462M27840
PathwayREACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION

PRKACA PRKACG GNAT3

3.66e-0443463M29837
PathwayREACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION

MCM8 CCNB1

3.70e-049462M5756
PathwayREACTOME_ROBO_RECEPTORS_BIND_AKAP5

PRKACA PRKACG

3.70e-049462M27877
PathwayREACTOME_GPER1_SIGNALING

PRKACA PRKACG GNAT3

4.19e-0445463M45008
PathwayKEGG_MEDICUS_REFERENCE_AVP_V2R_PKA_SIGNALING_PATHWAY

PRKACA PRKACG

4.61e-0410462M47648
PathwayBIOCARTA_AKAP95_PATHWAY

PRKACG CCNB1

5.62e-0411462M5731
PathwayREACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM

PRKACA PRKACG

6.73e-0412462M27950
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_ADENYLATE_CYCLASE

PRKACA PRKACG

6.73e-0412462M27363
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

PRKACA PRKACG GNAT3

7.18e-0454463M26911
PathwayKEGG_VIBRIO_CHOLERAE_INFECTION

ATP6V0A4 PRKACA PRKACG

7.18e-0454463M17906
PathwayWP_MRNA_PROCESSING

PTBP2 RBM5 CSTF3 SNRPB2

7.43e-04126464M39406
PathwayREACTOME_LOSS_OF_FUNCTION_OF_MECP2_IN_RETT_SYNDROME

NCOR2 PRKACA

7.94e-0413462M29766
PathwayWP_DOPAMINE_METABOLISM

PRKACA PRKACG

7.94e-0413462M39622
PathwayKEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY

PRKACA PRKACG

1.06e-0315462M47794
PathwayKEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY

PRKACA PRKACG

1.06e-0315462M47504
PathwayKEGG_MEDICUS_REFERENCE_DRD1_GNAS_AC_PKA_SIGNALING_PATHWAY

PRKACA PRKACG

1.21e-0316462M47551
PathwayKEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY

PRKACA PRKACG

1.21e-0316462M47645
PathwayKEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY

PRKACA PRKACG

1.21e-0316462M47650
PathwayREACTOME_RAP1_SIGNALLING

PRKACA PRKACG

1.21e-0316462M923
PathwayPID_HDAC_CLASSI_PATHWAY

HDAC9 NCOR2 PRKACA

1.29e-0366463M101
PathwayREACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING

PRKACA PRKACG

1.37e-0317462M26995
PathwayKEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY

PRKACA PRKACG

1.37e-0317462M47544
Pubmed

Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma.

DLK1 IFI16

2.93e-06260220214740
Pubmed

Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells.

PRKACA PRKACG

2.93e-06260215039079
Pubmed

The design of coiled-coil structures and assemblies.

CCDC74A CCDC168

2.93e-06260215837514
Pubmed

Retinoids repress Ah receptor CYP1A1 induction pathway through the SMRT corepressor.

NCOR2 AHR

2.93e-06260215325265
Pubmed

Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.

PRKACA PRKACG

8.77e-0636022342480
Pubmed

Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein.

PRKACA PRKACG

8.77e-06360212842892
Pubmed

Coiled coils: a highly versatile protein folding motif.

CCDC74A CCDC168

8.77e-06360211166216
Pubmed

Protein kinase A regulates cell cycle progression of mouse fertilized eggs by means of MPF.

PRKACA CCNB1

8.77e-06360215580572
Pubmed

The aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism.

NCOR2 AHR

8.77e-06360216480812
Pubmed

The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits.

PRKACA PRKACG

8.77e-06360219383776
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

PPP1R2 PHKA2 CABLES2 PRKACA PRKACG HP1BP3 CCNB1

9.52e-0643260723455922
Pubmed

CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.

ZNF462 FANCB LIAS CCDC146 ABCC11 SAMD3 ZUP1

1.07e-0544060735156780
Pubmed

Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex.

NCOR2 AHR

1.75e-05460210395741
Pubmed

Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype.

PRKACA PRKACG

1.75e-05460218385332
Pubmed

The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase.

ATP6V0A4 PRKACA

1.75e-05460225951193
Pubmed

Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets.

PRKACA PRKACG

1.75e-05460215632203
Pubmed

A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis.

PRKACA PRKACG

1.75e-05460212721358
Pubmed

The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression.

NCOR2 AHR

1.75e-05460212139968
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

SMCHD1 SUPT16H CSTF3 NUP188 SNRPB2 HP1BP3

2.68e-0534060629478914
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

GTF3C1 SMCHD1 SUPT16H PRKACG NUP188 HP1BP3

2.73e-0534160632971831
Pubmed

HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling.

PRKACA PRKACG

2.92e-05560212972513
Pubmed

Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways.

PRKACA PRKACG

2.92e-05560219483721
Pubmed

HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction.

PRKACA PRKACG

2.92e-05560221745501
Pubmed

Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts.

PRKACA PRKACG

2.92e-0556029540970
Pubmed

PKA-mediated stabilization of FoxH1 negatively regulates ERalpha activity.

PRKACA PRKACG

2.92e-05560219711044
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

LIAS APPBP2 GTF3C1 AHR GNAT3 NUP188 SAMD3 DNAH14

3.75e-0573660829676528
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

ZNF462 NCOR2 SMCHD1 SUPT16H CSTF3

3.98e-0522060535785414
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

NCOR2 ST6GAL2 MBTD1 PRTG TRANK1 RBM5 NUP188 DNAH14 HEPH CCDC33

4.02e-051215601015146197
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ZNF462 CABLES2 NCOR2 GTF3C1 MCM8 PTBP2 RBM5 CSTF3 NAALADL2 DNAH14 HP1BP3

4.24e-051489601128611215
Pubmed

Architectural DNA-binding properties of the spermatidal transition proteins 1 and 2.

PRKACA PRKACG

4.37e-0566029837753
Pubmed

Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation.

PRKACA PRKACG

4.37e-05660219197368
Pubmed

Regulation of a novel androgen receptor target gene, the cyclin B1 gene, through androgen-dependent E2F family member switching.

NCOR2 CCNB1

4.37e-05660222508987
Pubmed

Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin.

PRKACA PRKACG

6.11e-05760211438671
Pubmed

Dynamic binding of PKA regulatory subunit RI alpha.

PRKACA PRKACG

6.11e-05760216407073
Pubmed

Phosphorylation of HIV Nef by cAMP-dependent protein kinase.

PRKACA PRKACG

6.11e-05760215629779
Pubmed

BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing.

MCM8 GOLGA8H TEX15

6.15e-054460338085152
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

NCOR2 MBTD1 GTF3C1 SMCHD1 SUPT16H RBM5 NUP188 IFI16 SNRPB2 HP1BP3

6.80e-051294601030804502
Pubmed

Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression.

HDAC9 NCOR2

8.14e-05860211959865
Pubmed

HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism.

PRKACA PRKACG

8.14e-0586021978848
Pubmed

CCL3L1 prevents gp120-induced neuron death via the CREB cell signaling pathway.

PRKACA PRKACG

8.14e-05860219100722
Pubmed

HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro.

PRKACA PRKACG

8.14e-0586027946090
Pubmed

Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).

PRKACA PRKACG

8.14e-05860212628924
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

ZNF462 SLC25A18 GTF3C1 PTBP2 SUPT16H RBM5 CSTF3 SNRPB2 HP1BP3

9.39e-05108260938697112
Pubmed

Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.

HDAC9 NCOR2

1.05e-04960211466315
Pubmed

Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.

PRKACA PRKACG

1.05e-0496027688126
Pubmed

Ellis-van Creveld Syndrome

PRKACA WDR35

1.05e-04960237903214
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

FANCB GTF3C1 SMCHD1 RBM5 CSTF3 IFI16

1.31e-0445360629656893
Pubmed

HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition.

PRKACA PRKACG

1.31e-041060220433920
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

GLMN GTF3C1 SMCHD1 SUPT16H PRKACA RBM5 CSTF3 NUP188 HARS1 SNRPB2

1.50e-041425601030948266
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

ZNF462 GTF3C1 SMCHD1 SUPT16H USP16 CCNB1

1.58e-0446960627634302
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

PPP1R2 PHKA2 CABLES2 NCOR2 GTF3C1 SUPT16H NUP188 CCNB1

1.64e-0491060836736316
Pubmed

Analysis of BCL6-interacting proteins by tandem mass spectrometry.

HDAC9 NCOR2 WDR35

1.72e-046260316147992
Pubmed

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

PRKACA PRKACG

1.91e-041260210830164
Pubmed

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

ST6GAL2 MANBA MCM8 TLR6 HP1BP3

2.08e-0431360520800603
Pubmed

Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif.

PRKACA PRKACG

2.26e-041360218836454
Pubmed

Viral genetic determinants of nonprogressive HIV type 1 subtype C infection in antiretroviral drug-naive children.

PRKACA PRKACG

2.26e-041360219895210
Pubmed

MCM8 interacts with DDX5 to promote R-loop resolution.

MCM8 CCNB1

2.26e-041360238858601
Pubmed

The HIV-1 matrix protein p17 activates the transcription factors c-Myc and CREB in human B cells.

PRKACA PRKACG

2.26e-041360220402410
Pubmed

Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection.

PRKACA PRKACG

2.26e-041360220392842
Pubmed

Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS.

WDR35 RBM5 HP1BP3

2.26e-046860336966392
Pubmed

IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.

AHR TLR6

2.63e-041460223853597
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

SMCHD1 SUPT16H NUP188 IFI16 HP1BP3

2.73e-0433260525693804
Pubmed

cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.

PRKACA PRKACG

3.03e-04156022165385
Pubmed

A Y2H-seq approach defines the human protein methyltransferase interactome.

TAF1A CCDC74A ECI2 SAMD3 ZUP1

3.13e-0434260523455924
Pubmed

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

NCOR2 SMCHD1 NUP188

3.39e-047860328611094
Pubmed

Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all.

PRKACA PRKACG

3.91e-041760224189052
Pubmed

Oct4 links multiple epigenetic pathways to the pluripotency network.

NCOR2 PTBP2 SMCHD1 SUPT16H

4.26e-0420360422083510
Pubmed

Liganded ERα Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation.

USP16 CCNB1

4.91e-041960226389696
Pubmed

Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation.

PRKACA SYT1

4.91e-041960215529118
Pubmed

Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells.

GOLGA8H SYT1

4.91e-041960214622145
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

NCOR2 PTBP2 SMCHD1 CSTF3 SNRPB2 CCNB1

4.98e-0458260620467437
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NCOR2 GTF3C1 SMCHD1 RBM5 CSTF3 IFI16 SNRPB2 CCNB1

5.92e-04110360834189442
Pubmed

DJ-1 associates with synaptic membranes.

GOLGA8H SYT1

6.02e-042160221645620
Pubmed

The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.

PRKACA PRKACG

6.02e-042160222114277
Pubmed

Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.

PRKACA PRKACG

6.02e-04216029671211
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF462 GTF3C1 PTBP2 SMCHD1 SUPT16H HP1BP3

6.26e-0460860636089195
Pubmed

The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.

PRKACA PRKACG

6.61e-04226029151826
Pubmed

microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart.

PTBP2 CCNB1

6.61e-042260219015276
Pubmed

HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.

PRKACA PRKACG

7.23e-04236029730685
Pubmed

Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells.

NCOR2 DLK1

7.23e-042360219737349
Pubmed

The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.

PRKACA PRKACG

7.23e-04236029278385
Pubmed

The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis.

TLR6 ACE

7.23e-042360220207250
Pubmed

Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity.

PRKACA CCDC168

7.23e-042360222792062
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SLC25A18 GTF3C1 PTBP2 FAM186A SMCHD1 SUPT16H PRKACA RBM5 HP1BP3

7.76e-04144260935575683
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

PPP1R2 PHKA2 FANCB GTF3C1 GNAT3 NUP188 SNRPB2 CCNB1

7.99e-04115560820360068
Pubmed

Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.

SMCHD1 SUPT16H HP1BP3

8.30e-0410660319394292
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

PHKA2 SAMD9 GTF3C1 MCM8 GNAT3 HP1BP3

8.86e-0465060638777146
Pubmed

Comprehensive proteomic analysis of the human spliceosome.

RBM5 CSTF3 SNRPB2

9.00e-0410960312226669
Pubmed

Molecular mechanisms of bitter and sweet taste transduction.

TAS2R13 GNAT3

9.26e-042660211696554
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

SMCHD1 SUPT16H CSTF3 NUP188 SNRPB2 HP1BP3

9.58e-0466060632780723
Pubmed

Role of phosphorylation in the nuclear biology of HIV-1.

PRKACA PRKACG

9.99e-042760221651489
Pubmed

Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.

ATP6V0A4 CCNB1

1.07e-032860222808246
Pubmed

Notch signaling in stomach epithelial stem cell homeostasis.

CBLIF DLK1

1.15e-032960221402740
Pubmed

Isolation and characterization of proteins associated with histone H3 tails in vivo.

HDAC9 SUPT16H

1.23e-033060217403666
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

NCOR2 PTBP2 SMCHD1 SUPT16H CSTF3 SYT1 HP1BP3

1.25e-0395460736373674
Pubmed

The protein interaction landscape of the human CMGC kinase group.

PPP1R2 CABLES2 SUPT16H PRKACA NUP188 CCNB1

1.25e-0369560623602568
Pubmed

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.

HDAC9 PHKA2

1.32e-033160214684825
Pubmed

Glucagon and regulation of glucose metabolism.

PRKACA PRKACG

1.32e-033160212626323
Pubmed

The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.

SMCHD1 CSTF3 SNRPB2 CCNB1

1.43e-0328160424163370
Pubmed

KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.

PPP1R2 NCOR2 IFI16

1.49e-0313060335545047
CoexpressionPARENT_MTOR_SIGNALING_UP

LIAS SAMD9 TRANK1 GTF3C1 RBM5 SYT1 ECI2 NUP188 IFI16

5.39e-06567609M16909
ToppCellsevere_COVID-19-HSPC|severe_COVID-19 / disease group, cell group and cell class (v2)

ZNF462 ST6GAL2 PRTG ABCC11 DLK1 NAALADL2

1.29e-071746066d35bacf073537b272ff821e604c899fb9ce6a7c
ToppCellVE|World / Condition, Cell_class and T cell subcluster

SAMD9 TRANK1 SMCHD1 SAMD3 IFI16 HP1BP3

2.93e-072006068ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCellCOVID-19_Moderate-NK_activated|World / disease group, cell group and cell class

SAMD9 TRANK1 CCDC146 SAMD3 IFI16

5.20e-06186605ff8f32f69516bf785224fa12f8139a95359b0279
ToppCellMild-CD8+_T_activated|World / Disease group and Cell class

SAMD9 TRANK1 SMCHD1 SAMD3 IFI16

6.70e-0619660579632190e44fcef9d7c11d9b9e37f2ebf0e6e255
ToppCellCV-Moderate-1|CV / Virus stimulation, Condition and Cluster

SAMD9 TRANK1 SMCHD1 SAMD3 IFI16

6.87e-06197605e3d00d850b4d191f9592ef993c0eaadfe5710b5f
ToppCellMild-CD8+_T_activated|Mild / Disease group and Cell class

SAMD9 TRANK1 SMCHD1 SAMD3 IFI16

7.04e-06198605ceac1b51bacfd0dd7fe7c6a666f7927055e1f380
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF462 PRTG ATP6V0A4 DLK1

7.42e-0516660437794a84601a2a949d579663d4a4bb8bc8fb5923
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF462 PRTG ATP6V0A4 DLK1

7.42e-0516660481c546c6d847e49e662b81e71992ca0f7a99e890
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ST6GAL2 CCDC168 SAMD3 DNAH14

8.90e-05174604ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ST6GAL2 CCDC168 SAMD3 DNAH14

9.30e-0517660440993c41c1017b53039a337174fc56632b278609
ToppCellsevere_COVID-19-HSPC|World / disease group, cell group and cell class (v2)

ST6GAL2 ABCC11 DLK1 NAALADL2

9.51e-05177604289f6aed6f054b04b01659434d8c8b467d1bf5dd
ToppCellT_cells-ISG-high_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SAMD9 TRANK1 SMCHD1 IFI16

9.93e-05179604af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

SAMD9 TRANK1 SMCHD1 IFI16

1.08e-041836048f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellCOVID-19_Severe-CD8+_T_activated|COVID-19_Severe / Disease condition and Cell class

SAMD9 CCDC146 SAMD3 IFI16

1.15e-04186604fc087b79240fe7ada5810d4f4b3c7287eab598ff
ToppCellCOVID-19_Severe-Lymphoid_T/NK-CD8+_T_activated|COVID-19_Severe / Disease group, lineage and cell class

SAMD9 CCDC146 SAMD3 IFI16

1.17e-041876044c4c4406e16a15dedcd50bbcc2059d722a2e3d2c
ToppCellT_cells-ISG-high_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

SAMD9 TRANK1 SMCHD1 IFI16

1.20e-041886046f8946d4710f6e32c937213f99b790b098b8819c
ToppCell(7)_DC_1|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ZNF462 CCDC74A AHR ABCC11

1.20e-04188604832887afa4a54ed80906bc02176d646529c13398
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SAMD9 CCDC146 SAMD3 IFI16

1.25e-04190604b9182c84e44aa31684b5388cf3ef4fd1b9e51de4
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 CCDC146 SAMD3 IFI16

1.25e-0419060488c092a5e78ccaddf406f8fff74376bb761b9790
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SAMD9 CCDC146 SAMD3 IFI16

1.25e-041906044b42a16902d7d1494f953cc88af1e761e76bdf2c
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 CCDC146 SAMD3 IFI16

1.25e-041906049501f0995f3d52be90c02b1aa0c7d184bd788c16
ToppCellMild/Remission-B_activate-7|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SAMD9 TRANK1 SMCHD1 IFI16

1.27e-04191604382686d62f7b8576c44bb9726a4e10dc26fd348e
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

HDAC9 MANBA SMCHD1 WDR35

1.33e-0419360408696a99309f5b088692ddac8cca35413b5e810d
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-B_cell-B_cell-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HDAC9 CABLES2 GLMN LIAS

1.35e-041946049a99abc65e7509e7ae8fb392f5ee4b2a83128072
ToppCellMild/Remission-B_activate-7|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SAMD9 TRANK1 SMCHD1 IFI16

1.35e-0419460401c97543972159a9468272da06e7e611e2c21fae
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SAMD9 TRANK1 SMCHD1 IFI16

1.38e-04195604b64d9e1a8834401b4dc501566546647754ae21fc
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ZNF462 DLK1 HP1BP3 CCNB1

1.41e-041966048faac7fbdee3a9297023c3151ef1751605413e44
ToppCellmild-Myeloid-Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SAMD9 TRANK1 SMCHD1 IFI16

1.41e-04196604ded44b38ea489946e9eedfe752b5a9fde9149c16
ToppCellMild-CD4+_T_activated|World / Disease group and Cell class

SAMD9 TRANK1 SMCHD1 IFI16

1.41e-04196604417b4fc2e4388f34c410576131b02936f93e46b6
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-NK_dim-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SAMD9 GTF3C1 SAMD3 IFI16

1.41e-041966045b5cf6f70534661d694f47359b6595b4580876c3
ToppCellMild-CD4+_T_activated|Mild / Disease group and Cell class

SAMD9 TRANK1 SMCHD1 IFI16

1.41e-04196604daa1c3322d81e649161e889e1d78451d2d425d09
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 TRANK1 SMCHD1 IFI16

1.44e-041976040b4fdf0131dd67a86ee3209fa66db0ca2e01a10e
ToppCellsevere-Myeloid-Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SAMD9 TRANK1 SMCHD1 IFI16

1.44e-04197604c8a90d82170cf20e14aebecddcf7cc0ca56cda87
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 TRANK1 SMCHD1 IFI16

1.44e-04197604b3876076684781fb8384117f2cf367d828985986
ToppCellsystemic_lupus_erythematosus-treated|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SAMD9 SMCHD1 SAMD3 IFI16

1.46e-041986048165ff735095c52994fb5057d89be93cc378b7da
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SAMD9 SMCHD1 SAMD3 IFI16

1.46e-041986044c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 TRANK1 SAMD3 IFI16

1.46e-04198604ce92d5fbc2eac27fb246b044fb1914ab92506275
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SAMD9 TRANK1 SAMD3 IFI16

1.46e-04198604fed823d6e684d113bcc9ff3cd1803bb001aa02fa
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 TRANK1 SAMD3 IFI16

1.46e-041986040e918e9db9b884f5328d438e90efe065e27266ee
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SAMD9 TRANK1 SAMD3 IFI16

1.46e-041986041ef3a6bd681c223eed58300348adfef89df5563c
ToppCellCV-Mild-1|CV / Virus stimulation, Condition and Cluster

SAMD9 TRANK1 SMCHD1 IFI16

1.46e-041986044b078714c49e7befb7b113d72485e712236d35fa
ToppCellCOVID-19_Severe-Lymphoid_T/NK-NK_activated|COVID-19_Severe / Disease group, lineage and cell class

SAMD9 TRANK1 SAMD3 IFI16

1.49e-04199604edf5f80b4c299e6bf462675f2cd3329d86c923d8
ToppCellVE-CD4-antiviral_CD4|VE / Condition, Cell_class and T cell subcluster

SAMD9 TRANK1 SMCHD1 IFI16

1.49e-04199604056a0538ca5e825ae6195b4c76c208708a014533
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SMCHD1 AHR ACE IFI16

1.52e-04200604b7533c571eeea0cb3678e1a57d3dc036fa8d0f49
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SMCHD1 AHR ACE IFI16

1.52e-04200604a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCellmild-CD8+_Tem|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SAMD9 TRANK1 SMCHD1 SAMD3

1.52e-04200604d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-NK_activated|COVID-19_Severe / Disease, condition lineage and cell class

SAMD9 TRANK1 SAMD3 IFI16

1.52e-042006046a77f9643646bafc1157bf1fc1e4c614860ee642
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

SAMD9 TRANK1 SAMD3 IFI16

1.52e-042006042281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SMCHD1 AHR ACE IFI16

1.52e-04200604bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCellLPS_IL1RA_TNF-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SMCHD1 AHR ACE IFI16

1.52e-04200604d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCellControl_saline-Endothelial-Endothelial-Activated_Alv_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

SMCHD1 AHR ACE IFI16

1.52e-04200604be55cef682ba87250dad97689332c8820b3a7420
ToppCellLPS_only-Endothelial-Endothelial-Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

SMCHD1 AHR ACE IFI16

1.52e-04200604432384faeade8e609154fab3d96c955a8ec868dd
ToppCellSepsis-Int-URO-Myeloid-cDC1|Int-URO / Disease, condition lineage and cell class

ZNF462 HDAC9 CCDC74A SUPT16H

1.52e-0420060477479f733cc4ce62a07ab33d5dc2d41c911c74fc
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD8+_T_activated|COVID-19_Severe / Disease, condition lineage and cell class

SAMD9 CCDC146 SAMD3 IFI16

1.52e-04200604b7f80b2db07119069fbf3d245cf1ad79e8648bab
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SMCHD1 AHR ACE IFI16

1.52e-0420060489821a264e872ed53e08e9d3609d5cc5c314503e
ToppCellSepsis-URO-Myeloid-cDC1|URO / Disease, condition lineage and cell class

ZNF462 HDAC9 CCDC74A IFI16

1.52e-04200604c5ca81218be40b30e2f9252c1a004cb95d988447
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SMCHD1 AHR ACE IFI16

1.52e-0420060479e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Alv_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SMCHD1 AHR ACE IFI16

1.52e-0420060466f7e8ee63c828f17468e79a4b816346b33e8980
Drugrhodamine B base

AHR ACE

6.83e-062602CID000062357
Drug2,4-dimethyl-2-eicosenoic acid

FANCB DLK1

6.83e-062602CID005282673
Diseasecleft lip

NCOR2 PRTG ERCC6L2 DLK1 CCDC168 NAALADL2

2.01e-05284586EFO_0003959
DiseaseMale sterility

AHR GNAT3 ACE

1.17e-0448583C0917731
DiseaseMale infertility

AHR GNAT3 ACE

1.17e-0448583C0021364
DiseaseSubfertility, Male

AHR GNAT3 ACE

1.17e-0448583C0848676
DiseaseMYELODYSPLASTIC SYNDROME

FANCB SAMD9 DLK1

3.16e-0467583C3463824
DiseaseNon-alcoholic Fatty Liver Disease

PRKACA AHR ACE

3.59e-0470583C0400966
DiseaseNonalcoholic Steatohepatitis

PRKACA AHR ACE

3.59e-0470583C3241937
DiseaseCraniosynostosis

ZNF462 WDR35

7.05e-0420582C0010278
DiseaseFetal Growth Retardation

SAMD9 DLK1

7.05e-0420582C0015934
DiseaseLeft Ventricular Hypertrophy

AHR ACE

1.11e-0325582C0149721
DiseaseHematopoetic Myelodysplasia

SAMD9 DLK1

1.49e-0329582C2713368
Diseaselymphocyte percentage of leukocytes

PPP1R2 HDAC9 GLMN MANBA GTF3C1 IFI16

1.92e-03665586EFO_0007993

Protein segments in the cluster

PeptideGeneStartEntry
AMNFQGKLKYLHGQK

AHR

236

P35869
QAALLKQYQGKLQKM

CCDC33

736

Q8N5R6
LLQKNMQIANHTLKY

ACE

686

P12821
TYMDKLSKHGQQANK

APPBP2

191

Q92624
HMLRKKKNLLLQYNS

DLK1

341

P80370
HYKLIMNQTSQKKDG

CCDC74A

86

Q96AQ1
NSNYQMHLLKKTLQK

HP1BP3

376

Q5SSJ5
YHENIKINQAMRKKL

NCOR2

266

Q9Y618
TGNHYAMKILDKQKV

PRKACA

66

P17612
KQMKIIHKNGYSEQE

GNAT3

51

A8MTJ3
SQQYKGHKKMTTLQL

MBTD1

581

Q05BQ5
HYNKAKTVSENLKMG

MCM8

566

Q9UJA3
NKYEEGINIHLAKKM

CSTF3

191

Q12996
HSELMQKKGKYAQLI

ABCC11

716

Q96J66
MGKNYNKLKNTLRNL

LIAS

86

O43766
QKKLVIQGKHIAMHY

RBM5

161

P52756
EMKRKLHYNEGLNIK

PPP1R2

141

P41236
KIHSNGRIKMYNSKL

PRTG

366

Q2VWP7
KKMLQTNLKVSGALY

FANCB

821

Q8NB91
NQGLTKHMTVKNKYA

CCNB1

391

P14635
MNLAGAYNLKAQKLL

CBLIF

61

P27352
TGGHYAMKILNKQKV

PRKACG

66

P22612
LAKTRLQNQHGKAMY

SLC25A18

31

Q9H1K4
KMGNKYLQRTGVNLK

DNAH14

3036

Q0VDD8
GNKQMLYQAGLHFKL

MANBA

591

O00462
QKGKLNTDLYHMKRS

GOLGA8H

141

P0CJ92
VYGVFMLHKKTVNQK

IFI16

316

Q16666
NRPKKKNAINTEMYH

ECI2

156

O75521
SHKVILKANQQMPYK

CCDC168

4866

Q8NDH2
KYSGKMKVLQQLLNH

ERCC6L2

516

Q5T890
GQKRNQCLKKMIHVF

FAM186A

2216

A6NE01
KQYQQQIHMNKLLSK

HDAC9

476

Q9UKV0
NHTIYINNMNDKIKK

SNRPB2

6

P08579
MNKLTNIKRYHIAKV

HARS1

141

P12081
KGLKKTHFIKNMRQY

CABLES2

156

Q9BTV7
HIYAKLGRNKNMNLS

PHKA2

481

P46019
AMLQLYINKLDSQGK

GLMN

386

Q92990
PYVKIHLMQNGKRLK

SYT1

311

P21579
QKHLQKMQLNYKGHR

TAS2R13

206

Q9NYV9
FKKMENIQKLGNYTL

SMCHD1

776

A6NHR9
AMNHLNGQKMYGKII

PTBP2

391

Q9UKA9
GHQAVLMDLIKKYKQ

SAMD3

51

Q8N6K7
LMDLIKKYKQNTQGL

SAMD3

56

Q8N6K7
LKKSYHLNKSQIMLD

SAMD9

996

Q5K651
KNIGVMNYLKISLQH

TAF1A

126

Q15573
SNKMHAINGKLYANL

HEPH

961

Q9BQS7
LQKAMKDYLTANKHG

ST6GAL2

221

Q96JF0
LVINSKNQYKLKKGM

SUPT16H

361

Q9Y5B9
KQDTLLLAKKMNGYQ

CCDC146

796

Q8IYE0
GERKHVYTNAKKQML

USP16

671

Q9Y5T5
KMLQHYLQNKNGDGL

NUP188

1496

Q5SRE5
QNSIPNKYHKLKALM

TLR6

741

Q9Y2C9
ALILYHNKLKQGQSM

TMEM225

116

Q6GV28
LIKVQKMKAVYHILN

ATP6V0A4

296

Q9HBG4
LRKSMGNLKHKQYQI

ZUP1

536

Q96AP4
QKMYHKNNLKETTAP

ZNF462

181

Q96JM2
KLMELKLGKINQNYA

TEX15

361

Q9BXT5
QLVKYMNSGNRLLHK

TRANK1

336

O15050
YHRKILNKNGLITMQ

GTF3C1

211

Q12789
YHEQMKNAQRGKVKG

WDR35

981

Q9P2L0
TSLQGKKMAYQKVHA

NAALADL2

11

Q58DX5