Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	miRNA binding	DICER1 ZC3H10 AGO4 AGO3 QKI	2.43e-05	48	144	5	GO:0035198
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DOCK1 DOCK2 DENND2A PSD3 DOCK5 BCAR3 HERC2 HERC1 C9orf72	4.67e-05	231	144	9	GO:0005085
GeneOntologyMolecularFunction	regulatory RNA binding	DICER1 ZC3H10 AGO4 AGO3 QKI	8.46e-05	62	144	5	GO:0061980
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	POLR2A DICER1 CDKAL1 DUS2 FARSA POLR3B KARS1 ALKBH8 AGO4 AGO3 SMG6	2.25e-04	417	144	11	GO:0140098
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	POLR2A TERF2 DICER1 CDKAL1 DUS2 LIG3 FARSA POLR3B KARS1 ALKBH8 AGO4 AGO3 CHD5 SMG6	2.42e-04	645	144	14	GO:0140640
GeneOntologyMolecularFunction	double-stranded RNA binding	DICER1 DUS2 AGO4 AGO3 ZFR2	2.52e-04	78	144	5	GO:0003725
GeneOntologyCellularComponent	RISC-loading complex	DICER1 AGO4 AGO3	3.56e-05	10	142	3	GO:0070578
MousePheno	increased circulating insulin level	SLC5A10 TCF20 GLIS3 PPP1R3C FARSA KCNB1 CPT1C ARNT2 SIK2 BCAR3 HERC1	2.71e-05	283	118	11	MP:0002079
MousePheno	axonal dystrophy	UBE4B ATP8A2 DST HERC2	3.14e-05	22	118	4	MP:0003225
Domain	ARM-type_fold	DOCK1 DOCK2 XPO4 CUL9 USP9Y TRIP12 DOCK5 PPP2R1A ELMO3 IPO9 USO1 MTOR SYMPK	1.81e-06	339	141	13	IPR016024
Domain	DOCK_N	DOCK1 DOCK2 DOCK5	4.17e-06	5	141	3	PF16172
Domain	DOCK_N	DOCK1 DOCK2 DOCK5	4.17e-06	5	141	3	IPR032376
Domain	PAZ	DICER1 AGO4 AGO3	3.42e-05	9	141	3	PS50821
Domain	PAZ	DICER1 AGO4 AGO3	3.42e-05	9	141	3	SM00949
Domain	PAZ	DICER1 AGO4 AGO3	3.42e-05	9	141	3	PF02170
Domain	PAZ_dom	DICER1 AGO4 AGO3	3.42e-05	9	141	3	IPR003100
Domain	ARM-like	DOCK2 XPO4 CUL9 USP9Y TRIP12 PPP2R1A ELMO3 IPO9 MTOR SYMPK	3.96e-05	270	141	10	IPR011989
Domain	DHR-1_domain	DOCK1 DOCK2 DOCK5	6.65e-05	11	141	3	IPR027007
Domain	DHR_2	DOCK1 DOCK2 DOCK5	6.65e-05	11	141	3	PS51651
Domain	DHR_1	DOCK1 DOCK2 DOCK5	6.65e-05	11	141	3	PS51650
Domain	DHR-2	DOCK1 DOCK2 DOCK5	6.65e-05	11	141	3	PF06920
Domain	DOCK	DOCK1 DOCK2 DOCK5	6.65e-05	11	141	3	IPR026791
Domain	DOCK_C	DOCK1 DOCK2 DOCK5	6.65e-05	11	141	3	IPR010703
Domain	DOCK-C2	DOCK1 DOCK2 DOCK5	6.65e-05	11	141	3	PF14429
Domain	DHR-2	DOCK1 DOCK2 DOCK5	6.65e-05	11	141	3	IPR027357
Domain	Cul7	CUL9 HERC2	1.69e-04	3	141	2	PF11515
Domain	CPH_domain	CUL9 HERC2	1.69e-04	3	141	2	IPR021097
Domain	CEBP_ZZ	CPEB2 CPEB4	3.36e-04	4	141	2	PF16366
Domain	RRM_7	CPEB2 CPEB4	3.36e-04	4	141	2	PF16367
Domain	CEBP_ZZ	CPEB2 CPEB4	3.36e-04	4	141	2	IPR032296
Domain	Argonaute_N	AGO4 AGO3	3.36e-04	4	141	2	IPR032474
Domain	Argonaute_Mid_dom	AGO4 AGO3	3.36e-04	4	141	2	IPR032473
Domain	ArgoL2	AGO4 AGO3	3.36e-04	4	141	2	IPR032472
Domain	ArgoN	AGO4 AGO3	3.36e-04	4	141	2	PF16486
Domain	ArgoMid	AGO4 AGO3	3.36e-04	4	141	2	PF16487
Domain	ArgoL2	AGO4 AGO3	3.36e-04	4	141	2	PF16488
Domain	DUF1785	AGO4 AGO3	5.58e-04	5	141	2	SM01163
Domain	ArgoL1	AGO4 AGO3	8.32e-04	6	141	2	PF08699
Domain	ArgoL1	AGO4 AGO3	8.32e-04	6	141	2	IPR014811
Domain	HECT	TRIP12 HERC2 HERC1	1.08e-03	27	141	3	PF00632
Domain	HECTc	TRIP12 HERC2 HERC1	1.08e-03	27	141	3	SM00119
Domain	HECT_dom	TRIP12 HERC2 HERC1	1.08e-03	27	141	3	IPR000569
Domain	HECT	TRIP12 HERC2 HERC1	1.08e-03	27	141	3	PS50237
Domain	APC_su10/DOC_dom	CUL9 HERC2	1.16e-03	7	141	2	IPR004939
Domain	DOC	CUL9 HERC2	1.16e-03	7	141	2	PS51284
Domain	Yip1	YIPF4 YIPF7	1.16e-03	7	141	2	IPR006977
Domain	ANAPC10	CUL9 HERC2	1.16e-03	7	141	2	PF03256
Domain	Yip1	YIPF4 YIPF7	1.16e-03	7	141	2	PF04893
Domain	APC10	CUL9 HERC2	1.16e-03	7	141	2	SM01337
Domain	-	XPO4 CUL9 TRIP12 PPP2R1A IPO9 MTOR SYMPK	1.50e-03	222	141	7	1.25.10.10
Domain	PIWI	AGO4 AGO3	1.54e-03	8	141	2	PS50822
Domain	Piwi	AGO4 AGO3	1.54e-03	8	141	2	SM00950
Domain	Piwi	AGO4 AGO3	1.54e-03	8	141	2	PF02171
Domain	Piwi	AGO4 AGO3	1.54e-03	8	141	2	IPR003165
Domain	PHD	TCF20 KMT2D CHD5 KDM2A	4.63e-03	89	141	4	SM00249
Domain	SEA	HSPG2 MUC17	4.85e-03	14	141	2	SM00200
Domain	Znf_PHD	TCF20 KMT2D CHD5 KDM2A	5.01e-03	91	141	4	IPR001965
Domain	ZF_PHD_2	TCF20 KMT2D CHD5 KDM2A	5.83e-03	95	141	4	PS50016
Domain	SH3	DOCK1 DOCK2 NEBL DOCK5 DST MAP3K21	6.01e-03	216	141	6	PS50002
Domain	ZF_PHD_1	TCF20 KMT2D CHD5 KDM2A	6.05e-03	96	141	4	PS01359
Domain	SH3_domain	DOCK1 DOCK2 NEBL DOCK5 DST MAP3K21	6.55e-03	220	141	6	IPR001452
Pathway	BIOCARTA_DICER_PATHWAY	DICER1 AGO4 AGO3	4.83e-06	5	112	3	M22079
Pathway	BIOCARTA_FREE_PATHWAY	XDH GSR GSS	2.66e-05	8	112	3	MM1400
Pathway	REACTOME_DISEASES_OF_METABOLISM	HSPG2 TCN2 HLCS GALNT12 GSS B4GALT1 PPP1R3C MUC17 GYS1 OPLAH	2.98e-05	250	112	10	M27554
Pathway	REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS	DICER1 AGO4 AGO3	3.96e-05	9	112	3	M27340
Pathway	REACTOME_MICRORNA_MIRNA_BIOGENESIS	POLR2A DICER1 AGO4 AGO3	4.20e-05	25	112	4	M712
Pathway	BIOCARTA_FREE_PATHWAY	XDH GSR GSS	5.63e-05	10	112	3	M96
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	NUP85 UBE4B TMEM115 GALNT12 TRIP12 PHGDH CDKAL1 PPP2R1A NAA35 FARSA KARS1 IPO9 USO1 MTOR PA2G4 GEMIN4 EMC10 QKI SEC23A SYMPK	3.03e-09	942	146	20	31073040
Pubmed	The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.	DOCK1 DOCK2 DOCK5 ELMO3	2.07e-07	13	146	4	21930703
Pubmed	A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.	ZKSCAN1 MTOR QKI	2.89e-07	4	146	3	36691031
Pubmed	Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.	DICER1 AGO4 AGO3	7.20e-07	5	146	3	19393748
Pubmed	Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.	UBE4B TRIP12 HERC2	7.20e-07	5	146	3	22124266
Pubmed	The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo.	DOCK1 DOCK2 DOCK5	7.20e-07	5	146	3	24365888
Pubmed	Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.	DICER1 AGO4 AGO3	7.20e-07	5	146	3	12526743
Pubmed	Differential expression of components of the microRNA machinery during mouse organogenesis.	DICER1 AGO4 AGO3	7.20e-07	5	146	3	16036130
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 NUP85 UBE4B POLR2A CUL9 BABAM2 KCNH3 SLC38A10 KMT2D DST CELSR3 MTOR BTBD7 CHD5 HERC2 HERC1 SMG6 SYMPK	9.81e-07	1105	146	18	35748872
Pubmed	mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion.	POLR2A TSC1 MTOR	1.44e-06	6	146	3	25332234
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	TCF20 NUP85 UBE4B POLR2A LIG3 KMT2D KARS1 GEMIN4 KDM2A SYMPK	1.96e-06	341	146	10	32971831
Pubmed	Defining the membrane proteome of NK cells.	DOCK2 NUP85 APMAP CDKAL1 B4GALT1 BPNT2 FARSA IPO9 AGO4 AGO3 USO1 MTOR PA2G4 GYS1 CHD5 GEMIN4 HERC2 ITPRIPL1	2.14e-06	1168	146	18	19946888
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	TCF20 NEBL POLR2A HLCS TSC1 DICER1 CDKAL1 STRIP2 FARSA POLR3B USO1 ARNT2 MGA ITPRIPL1	2.81e-06	733	146	14	34672954
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TCF20 WDR81 DPYSL4 TSC1 PPP2R1A FARSA SLC7A3 DST AGO3 KCNB1 ZKSCAN1 MTOR HERC2 MGA SEC23A SMG6	3.19e-06	963	146	16	28671696
Pubmed	Suppression of microRNA Activity in Kidney Collecting Ducts Induces Partial Loss of Epithelial Phenotype and Renal Fibrosis.	DICER1 AGO4 AGO3	4.00e-06	8	146	3	29021386
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TCF20 POLR2A CUL9 TRIP12 DICER1 PPP2R1A KARS1 DST MTOR GEMIN4 HERC2 SEC23A SYMPK	4.15e-06	653	146	13	22586326
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	TCF20 UBE4B POLR2A TSC1 TRIP12 PHGDH LIG3 PPP2R1A NAA35 POLR3B KARS1 IPO9 DST PA2G4 GEMIN4 KDM2A HERC2 MGA SEC23A	4.22e-06	1353	146	19	29467282
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	DOCK1 CPEB2 DICER1 PPP2R1A KARS1 AGO4 AGO3 ZKSCAN1 CPEB4 SFXN2 QKI	4.43e-06	462	146	11	31138677
Pubmed	Identification of eight members of the Argonaute family in the human genome.	DICER1 AGO4 AGO3	5.98e-06	9	146	3	12906857
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TCF20 UBE4B ATG13 PSD3 CUL9 TSC1 SNX19 STRIP2 BTBD7 ZFR2	9.30e-06	407	146	10	12693553
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CCDC137 NUP85 XPO4 SNX19 DICER1 PHGDH CDKAL1 PDXK LIG3 PPP2R1A FARSA POLR3B KARS1 IPO9 DST MTOR PA2G4 GEMIN4 COMMD10	1.02e-05	1440	146	19	30833792
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	NUP85 XPO4 PHGDH PPP2R1A IPO9 MTOR GEMIN4	1.30e-05	183	146	7	23956138
Pubmed	Critical role for hypothalamic mTOR activity in energy balance.	TSC1 MTOR	1.75e-05	2	146	2	19356717
Pubmed	Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes.	TSC1 MTOR	1.75e-05	2	146	2	33352197
Pubmed	Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival.	TRMT112 ALKBH8	1.75e-05	2	146	2	20308323
Pubmed	TSC/MTOR mutated renal cell carcinoma with leiomyomatous stroma is a distinct entity: a comprehensive study of 12 cases.	TSC1 MTOR	1.75e-05	2	146	2	36592877
Pubmed	Prognostic implication of TSC1 and mTOR expression in gastric carcinoma.	TSC1 MTOR	1.75e-05	2	146	2	24615476
Pubmed	Selective Response to Mammalian Target of Rapamycin Inhibition in a Patient with Metastatic Renal Cell Carcinoma Bearing TSC1 Mutation.	TSC1 MTOR	1.75e-05	2	146	2	25796537
Pubmed	Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1.	DOCK1 DOCK2	1.75e-05	2	146	2	28467910
Pubmed	DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.	DOCK2 DOCK5	1.75e-05	2	146	2	25339677
Pubmed	Selective Tuberous Sclerosis Complex 1 Gene Deletion in Smooth Muscle Activates Mammalian Target of Rapamycin Signaling and Induces Pulmonary Hypertension.	TSC1 MTOR	1.75e-05	2	146	2	26991739
Pubmed	Mammalian target of rapamycin complex 1 activation in podocytes promotes cellular crescent formation.	TSC1 MTOR	1.75e-05	2	146	2	24990893
Pubmed	KMT2D regulates activation, localization, and integrin expression by T-cells.	KMT2D COMMD10	1.75e-05	2	146	2	38765012
Pubmed	Collagen type IV and Perlecan exhibit dynamic localization in the Allantoic Core Domain, a putative stem cell niche in the murine allantois.	COL4A1 HSPG2	1.75e-05	2	146	2	19924818
Pubmed	mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.	TSC1 MTOR	1.75e-05	2	146	2	19934433
Pubmed	mRNA 3'-UTR shortening is a molecular signature of mTORC1 activation.	TSC1 MTOR	1.75e-05	2	146	2	26074333
Pubmed	GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease.	PPP1R3C GYS1	1.75e-05	2	146	2	33034425
Pubmed	PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism.	PPP1R3C GYS1	1.75e-05	2	146	2	9045612
Pubmed	Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation.	TSC1 MTOR	1.75e-05	2	146	2	15185396
Pubmed	Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.	TRMT112 ALKBH8	1.75e-05	2	146	2	20123966
Pubmed	mTORC1 Activation Promotes Spermatogonial Differentiation and Causes Subfertility in Mice.	TSC1 MTOR	1.75e-05	2	146	2	27605345
Pubmed	Activation of mTORC1 in collecting ducts causes hyperkalemia.	TSC1 MTOR	1.75e-05	2	146	2	24203997
Pubmed	Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling.	TSC1 MTOR	1.75e-05	2	146	2	21268018
Pubmed	Critical roles for the TSC-mTOR pathway in β-cell function.	TSC1 MTOR	1.75e-05	2	146	2	19690069
Pubmed	Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies.	GSS OPLAH	1.75e-05	2	146	2	25851806
Pubmed	TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species.	TSC1 MTOR	1.75e-05	2	146	2	18809716
Pubmed	TSC/MTOR -associated Eosinophilic Renal Tumors Exhibit a Heterogeneous Clinicopathologic Spectrum : Several Distinct Entities or a Tumor Family?	TSC1 MTOR	1.75e-05	2	146	2	36727758
Pubmed	Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas.	DICER1 KMT2D	1.75e-05	2	146	2	26841698
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	PDXK AGO3 HERC2 MGA SEC23A	1.77e-05	76	146	5	27542412
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	ASNSD1 APMAP TRIP12 DICER1 PHGDH DUS2 FARSA KARS1 IPO9 AGO3 USO1 PA2G4 CPEB4 GEMIN4 HERC2 QKI CRBN SEC23A	1.90e-05	1371	146	18	36244648
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK1 DOCK2 DOCK5	2.55e-05	14	146	3	12432077
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	TCF20 NUP85 APMAP POLR2A TRIP12 DICER1 PHGDH LIG3 PPP2R1A DST PA2G4 HERC2 MGA SEC23A CXADR	2.87e-05	1024	146	15	24711643
Pubmed	LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway.	PHGDH TGFBI PPP2R1A KARS1 IPO9 DST	3.16e-05	142	146	6	30809309
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	HLCS C16orf96 STRIP2 PPP1R3C LIG3 PPP2R1A AGO3 PA2G4 GYS1 GEMIN4 HERC1	3.26e-05	573	146	11	28330616
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	CCDC137 CUL9 TRIP12 DICER1 STRIP2 DST HERC2	3.35e-05	212	146	7	33853758
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	PSD3 USP9Y PPP2R1A IPO9 HERC2	3.41e-05	87	146	5	17148452
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DOCK1 DOCK2 TRIP12 PHGDH DOCK5 PPP2R1A IPO9 USO1 GEMIN4 SEC23A SYMPK	3.75e-05	582	146	11	20467437
Pubmed	Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs.	DICER1 AGO4 AGO3	3.90e-05	16	146	3	20102707
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	ASNSD1 UBE4B OR13C8 XPO4 TSC1 SYS1 DICER1 MAD2L1BP GSR GSS NAA35 ALKBH8 SLC7A3 IPO9 BTBD7 KDM2A MGA	4.46e-05	1327	146	17	32694731
Pubmed	Proteomics analysis of the estrogen receptor alpha receptosome.	POLR2A PPP2R1A FARSA KARS1 PA2G4	4.70e-05	93	146	5	20348541
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	DOCK1 APMAP PSD3 HLCS PHGDH CDKAL1 PPP2R1A FARSA DST USO1 GEMIN4 MAP3K21	4.75e-05	708	146	12	39231216
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PSD3 DICER1 DST CHD5 SIK2 KDM2A SMG6	4.89e-05	225	146	7	12168954
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	NUP85 PHGDH PDXK LIG3 PPP2R1A USO1 MTOR PA2G4 SEC23A	5.20e-05	400	146	9	35013556
Pubmed	Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.	TSC1 MTOR	5.24e-05	3	146	2	17562867
Pubmed	miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-κB in high-grade serous ovarian carcinoma.	TSC1 MTOR	5.24e-05	3	146	2	28800130
Pubmed	Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria.	ACO1 ALAS2	5.24e-05	3	146	2	24509859
Pubmed	Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.	TSC1 MTOR	5.24e-05	3	146	2	15624760
Pubmed	Role of DOCK2 and DOCK180 in fetal thymus colonization.	DOCK1 DOCK2	5.24e-05	3	146	2	19728314
Pubmed	mTOR activation protects liver from ischemia/reperfusion-induced injury through NF-κB pathway.	TSC1 MTOR	5.24e-05	3	146	2	28356345
Pubmed	Tsc1 haploinsufficiency without mammalian target of rapamycin activation is sufficient for renal cyst formation in Tsc1+/- mice.	TSC1 MTOR	5.24e-05	3	146	2	16912167
Pubmed	mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.	TSC1 MTOR	5.24e-05	3	146	2	29056426
Pubmed	Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer.	TSC1 MTOR	5.24e-05	3	146	2	31961824
Pubmed	Mutations in TSC1, TSC2, and MTOR Are Associated with Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma.	TSC1 MTOR	5.24e-05	3	146	2	26831717
Pubmed	Eosinophilic Renal Cell Tumors With a TSC and MTOR Gene Mutations Are Morphologically and Immunohistochemically Heterogenous: Clinicopathologic and Molecular Study.	TSC1 MTOR	5.24e-05	3	146	2	32091432
Pubmed	Low-grade oncocytic tumor of kidney harboring TSC/MTOR mutation: clinicopathologic, immunohistochemical and molecular characteristics support a distinct entity.	TSC1 MTOR	5.24e-05	3	146	2	35099634
Pubmed	Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells.	TSC1 MTOR	5.24e-05	3	146	2	21674478
Pubmed	Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1.	TSC1 MTOR	5.24e-05	3	146	2	23878397
Pubmed	Surmounting limited gene delivery into primary immune cell populations: Efficient cell type-specific adenoviral transduction by CAR.	COMMD10 CXADR	5.24e-05	3	146	2	25903647
Pubmed	Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy.	TSC1 MTOR	5.24e-05	3	146	2	23169238
Pubmed	mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.	TSC1 MTOR	5.24e-05	3	146	2	31534053
Pubmed	A new homozygous HERC1 gain-of-function variant in MDFPMR syndrome leads to mTORC1 hyperactivation and reduced autophagy during cell catabolism.	TSC1 HERC1	5.24e-05	3	146	2	32921582
Pubmed	mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.	TSC1 MTOR	5.24e-05	3	146	2	26931735
Pubmed	Glycogen synthase downregulation rescues the amylopectinosis of murine RBCK1 deficiency.	PPP1R3C GYS1	5.24e-05	3	146	2	35084461
Pubmed	Hypervascularization in mTOR-dependent focal and global cortical malformations displays differential rapamycin sensitivity.	TSC1 MTOR	5.24e-05	3	146	2	31125447
Pubmed	Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle.	CPEB2 CPEB4	5.24e-05	3	146	2	26398195
Pubmed	DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.	DOCK2 DOCK5	5.24e-05	3	146	2	24913231
Pubmed	Interaction between protein phosphatase 2A and members of the importin beta superfamily.	PPP2R1A IPO9	5.24e-05	3	146	2	12670497
Pubmed	Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins.	MTOR PA2G4	5.24e-05	3	146	2	30224479
Pubmed	The PINK1 p.Asn521Thr Variant Is Associated with Earlier Disease Onset in GRN/C9orf72 Frontotemporal Lobar Degeneration.	C9orf72 PINK1	5.24e-05	3	146	2	36361641
Pubmed	DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis.	DOCK2 DOCK5	5.24e-05	3	146	2	36804596
Pubmed	T-cell-specific mTOR deletion in mice ameliorated CD4+ T-cell survival in lethal sepsis induced by severe invasive candidiasis.	TSC1 MTOR	5.24e-05	3	146	2	31668132
Pubmed	DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway.	TSC1 MTOR	5.24e-05	3	146	2	29378913
Pubmed	mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis.	TSC1 MTOR	5.24e-05	3	146	2	26382847
Pubmed	TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.	TSC1 HERC1	5.24e-05	3	146	2	16464865
Pubmed	CPEB2, a novel putative translational regulator in mouse haploid germ cells.	CPEB2 CPEB4	5.24e-05	3	146	2	12672660
Pubmed	Role of TSC-mTOR pathway in diabetic nephropathy.	TSC1 MTOR	5.24e-05	3	146	2	18926585
Pubmed	mTORC1 Signaling is a Critical Regulator of Postnatal Tendon Development.	TSC1 MTOR	5.24e-05	3	146	2	29215029
Pubmed	A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?	GSS OPLAH	5.24e-05	3	146	2	20413906
Pubmed	IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance.	TSC1 MTOR	5.24e-05	3	146	2	24333417
Pubmed	An mTurq2-Col4a1 mouse model allows for live visualization of mammalian basement membrane development.	COL4A1 HSPG2	5.24e-05	3	146	2	38051393
Interaction	FKBP5 interactions	ASNSD1 EPHB6 NUP85 DICER1 PPP2R1A POLR3B AGO4 AGO3 MAPK7 C9orf72 MAP3K21 PINK1 SYMPK	7.62e-06	414	142	13	int:FKBP5
Interaction	LMBR1L interactions	NUP85 UBE4B TMEM115 GALNT12 TRIP12 PHGDH CDKAL1 PPP2R1A NAA35 FARSA KARS1 IPO9 USO1 MTOR PA2G4 GEMIN4 EMC10 QKI SEC23A SYMPK	1.08e-05	946	142	20	int:LMBR1L
GeneFamily	Yip1 domain containing	YIPF4 YIPF7	5.29e-04	7	92	2	105
GeneFamily	Argonaute/PIWI family	AGO4 AGO3	7.03e-04	8	92	2	408
Coexpression	DURCHDEWALD_SKIN_CARCINOGENESIS_DN	DOCK1 TMEM248 XDH GALNT12 GSR B4GALT1 TGFBI CPEB4 COMMD10 BCAR3 QKI	3.01e-07	265	146	11	M1684
Coexpression	DURCHDEWALD_SKIN_CARCINOGENESIS_DN	DOCK1 TMEM248 XDH GALNT12 GSR B4GALT1 TGFBI CPEB4 COMMD10 BCAR3 QKI	3.90e-07	272	146	11	MM1027
Coexpression	GSE37301_HEMATOPOIETIC_STEM_CELL_VS_LYMPHOID_PRIMED_MPP_UP	DENND2A ACO1 GALNT12 FANCE BTBD7 CPEB4 HERC1 PINK1	7.65e-06	179	146	8	M8828
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP	TCN2 GALNT12 ZNF385B PPP1R3C	1.47e-05	27	146	4	M14833
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP	TCN2 GALNT12 ZNF385B PPP1R3C	3.33e-05	33	146	4	MM477
Coexpression	TBK1.DF_DN	COL4A1 TERF2 DICER1 ITGB6 NAA35 POLR3B ZKSCAN1 GEMIN4 CXADR	3.39e-05	286	146	9	M2864
Coexpression	LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN	CPEB2 DNAJC9-AS1 UBE4B TMEM115 DPYSL4 SNX19 ALKBH8 AGO4 ATRIP AGO3 MTOR CHD5 TMEM35B CRBN PINK1	4.69e-05	807	146	15	M14594
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 CPEB2 COL4A1 DENND2A NEBL GLIS3 ITGB6 ARNT2	2.33e-07	191	146	8	9032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 CPEB2 COL4A1 DENND2A NEBL GLIS3 ITGB6 ARNT2	2.33e-07	191	146	8	5717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NUP85 ATG13 HLCS XPO4 ZSWIM1 CDKAL1 DOCK5 LIG3	2.62e-07	194	146	8	0e9830ad070c47acaa952400bf2a3ddbff664a2f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 DENND2A PSD3 GLIS3 ITGB6 DST SLC15A1 ARNT2	2.73e-07	195	146	8	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 DENND2A PSD3 GLIS3 ITGB6 DST SLC15A1 ARNT2	2.73e-07	195	146	8	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	facs-Skin-Anagen-24m-Epithelial-inner_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR155 WDR81 HLCS GSS ZFR2 HERC2	9.77e-07	100	146	6	97ca9cda55a05fbb4d1f5d61f847c965e014f05c
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_1\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	GPR155 PRTG SLC7A3 ARNT2 SIK2 MAPK7	1.95e-05	168	146	6	53a982869dbf14f6a948589be9f2f3df3b9a7e97
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRTG ITGB6 KCNH3 TGFBI HRH1 PPP1R36	2.09e-05	170	146	6	a121e10099faaeb60251eec162f38caf7c4238c2
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_mature_DC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CPEB2 PSD3 ITGB6 KCNH3 ATRIP PLAG1	2.16e-05	171	146	6	341f9f79c1ed654ab347e25dc4936f89ffdf9617
ToppCell	facs\|World / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TCN2 POLR2A B4GALT1 PPP2R1A KARS1 ITPRIPL1	2.16e-05	171	146	6	bb71e816dde44fda6af0ad98d979be9f8740fda6
ToppCell	facs\|World / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCN2 POLR2A B4GALT1 PPP2R1A KARS1 ITPRIPL1	2.16e-05	171	146	6	5bcb96ed7fc15548f2dc9cf47482f890640cb39c
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|356C / Donor, Lineage, Cell class and subclass (all cells)	EPHB6 GPR155 HLCS P2RY8 MTOR AGMAT	2.30e-05	173	146	6	e3cb7c8c09f937da6b8d673e9adfec5d94a15548
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRTG ITGB6 KCNH3 TGFBI HRH1 PPP1R36	2.46e-05	175	146	6	f7cd2ef79d91d64976fcdb5f1e7343b24ba27456
ToppCell	18-Airway-Epithelial-Submucosal_gland_basal\|Airway / Age, Tissue, Lineage and Cell class	COL4A1 XDH ITGB6 GSS ZFR2 GASK1A	2.97e-05	181	146	6	33938e6521712058312879f84f4ae381c2bfc379
ToppCell	droplet-Heart-nan-18m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF5 C11orf16 LRRC46 CHD5 PPP1R36 CXADR	3.16e-05	183	146	6	1701c8c212f1fdb6e4764375542a203e19753d14
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Lymphocytic-T_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XPO4 DICER1 PHGDH GSR FARSA ELMO3	3.25e-05	184	146	6	185b49630da61cbf45c0926d1b992943296d2a54
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	NEBL PSD3 LMOD2 DST CPEB4 QKI	3.25e-05	184	146	6	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	Control-Myeloid-Macrophage_Alveolar\|World / Disease state, Lineage and Cell class	ACER3 ACO1 DST SIK2 HRH1 BCAR3	3.35e-05	185	146	6	85cb81759589a26d83676cffbf2bc37399683c10
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CPEB2 DENND2A PSD3 ITGB6 DST HRH1	3.56e-05	187	146	6	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CPEB2 DENND2A PSD3 ITGB6 DST HRH1	3.56e-05	187	146	6	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CPEB2 DENND2A PSD3 ITGB6 DST HRH1	3.56e-05	187	146	6	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	Control-Myeloid-Macrophage_Alveolar\|Control / Disease state, Lineage and Cell class	ACER3 ACO1 PSD3 DST SIK2 HRH1	3.78e-05	189	146	6	937e876122bc4b94372a4104e9c1a9068c232018
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPEB2 DENND2A GLIS3 ITGB6 DST ARNT2	3.78e-05	189	146	6	8c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPEB2 DENND2A GLIS3 ITGB6 DST ARNT2	3.78e-05	189	146	6	5d902a4660a27548764bf04c6de152b565da835c
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	NEBL PSD3 LMOD2 CPEB4 EMC10 QKI	3.78e-05	189	146	6	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	NEBL PSD3 LMOD2 CPEB4 EMC10 QKI	3.89e-05	190	146	6	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	facs-Tongue-nan-3m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPEB2 EPHB6 NEBL TCN2 XDH ITGB6	3.89e-05	190	146	6	719a5cecc3e8001ca9c38165258b5ff9c800713a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 COL4A1 DENND2A NEBL GLIS3 ITGB6	4.01e-05	191	146	6	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	droplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEBL YIPF7 LMOD2 STRIP2 PPP1R3C CXADR	4.01e-05	191	146	6	97fb4232417a39801e87725755fd16a57c250209
ToppCell	Control-Myeloid-Macrophage_Alveolar\|Myeloid / Disease state, Lineage and Cell class	ACER3 ACO1 PSD3 DST SIK2 HRH1	4.01e-05	191	146	6	a7bb8aba9c59c037d995a77928cc7b4d5cbb82b9
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HLCS COX18 C2orf74 USP9Y DICER1 QKI	4.01e-05	191	146	6	cadb7a9de16f4bb21606de0e25cddd2d748c7f0b
ToppCell	droplet-Heart-nan-3m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEBL YIPF7 LMOD2 STRIP2 PPP1R3C CXADR	4.01e-05	191	146	6	64070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 CPEB2 DENND2A GLIS3 ITGB6 ARNT2	4.25e-05	193	146	6	263d185af6ed80e639f864e4966268e0862c61dc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 CPEB2 DENND2A GLIS3 ITGB6 ARNT2	4.25e-05	193	146	6	80e058c224749b5fe0ba3e944b48317c2371cb63
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 CPEB2 DENND2A GLIS3 ITGB6 ARNT2	4.25e-05	193	146	6	b991fbbb4618401624f0b3045f0e81a606d3a763
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	NEBL PSD3 LMOD2 DST CPEB4 EMC10	4.50e-05	195	146	6	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	droplet-Trachea-3m-Epithelial-airway_epithelial-epithelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IGSF5 LMOD2 ITGB6 PDXK KCNH3 SLC14A2	4.50e-05	195	146	6	4d7ca21f14730e1b6d0473bc1a11aa626db948f3
ToppCell	droplet-Trachea-3m-Epithelial-airway_epithelial-epithelial_cell-epithelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IGSF5 LMOD2 ITGB6 PDXK KCNH3 SLC14A2	4.50e-05	195	146	6	8727554ef047ca7f1d4b888a8468f148c64a6918
ToppCell	droplet-Trachea-nan-3m-Epithelial-epithelial_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF5 LMOD2 ITGB6 PDXK KCNH3 SLC14A2	4.50e-05	195	146	6	9f0ee826d4f0997aee8d63284ed24549bbdf6a28
ToppCell	Biopsy_IPF-Epithelial-AT1\|Biopsy_IPF / Sample group, Lineage and Cell type	COL4A1 HSPG2 NEBL ITGB6 DST PTPRQ	4.90e-05	198	146	6	75bdecbe111fededf6082b11de18b84ca308ef6d
ToppCell	(02)_MMP9/10+-(1)_GFP\|(02)_MMP9/10+ / shred by cell type by condition	COL4A1 ITGB6 B4GALT1 TGFBI PPP2R1A BCAR3	5.03e-05	199	146	6	448ba982be804007f991d469eca9d885b21ae499
ToppCell	Biopsy_Control_(H.)-Epithelial-AT1\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	COL4A1 HSPG2 NEBL ITGB6 DST CXADR	5.18e-05	200	146	6	3a9633f5913f12b6865fc777c84f3f3ba795a78d
Disease	FEV/FEC ratio	COL4A1 HSPG2 NEBL GLIS3 GALNT12 SYS1 BABAM2 FANCE DST ZKSCAN1 CPT1C CPEB4 HERC1 MGA SLC14A2 RNF32-DT CXADR SMG6	2.89e-05	1228	143	18	EFO_0004713
Disease	urate measurement	NEBL SLC22A11 PSD3 GLIS3 XDH BABAM2 ITGB6 PHGDH CDKAL1 B4GALT1 CPT1C CPEB4 AGMAT SLC14A2 RNF32-DT	3.12e-05	895	143	15	EFO_0004531
Disease	Focal Cortical Dysplasia of Taylor, Type IIb	TSC1 MTOR	6.97e-05	3	143	2	C1846389
Disease	FOCAL CORTICAL DYSPLASIA OF TAYLOR	TSC1 MTOR	6.97e-05	3	143	2	C1846385
Disease	Focal Cortical Dysplasia of Taylor, Type IIa	TSC1 MTOR	6.97e-05	3	143	2	C1846386
Disease	Isolated focal cortical dysplasia type II	TSC1 MTOR	6.97e-05	3	143	2	cv:C1846385
Disease	FOCAL CORTICAL DYSPLASIA, TYPE II	TSC1 MTOR	6.97e-05	3	143	2	607341
Disease	cerebellar ataxia, mental retardation and dysequlibrium syndrome (is_implicated_in)	ATP8A2 WDR81	1.39e-04	4	143	2	DOID:0050997 (is_implicated_in)
Disease	Dysequilibrium syndrome	ATP8A2 WDR81	2.31e-04	5	143	2	C0394006
Disease	Intellectual Disability	TCF20 TCN2 ATP8A2 PPP2R1A POLR3B KARS1 ALKBH8 MTOR QKI	3.46e-04	447	143	9	C3714756
Disease	Global developmental delay	COL4A1 TCF20 POLR2A KARS1 ALKBH8	4.87e-04	133	143	5	C0557874
Disease	peak expiratory flow	GLIS3 GALNT12 PHGDH DST SLC15A1 SFXN2 PLAG1 KDM2A RNF32-DT	7.50e-04	498	143	9	EFO_0009718
Disease	Developmental delay (disorder)	COL4A1 TCF20 ALKBH8	7.67e-04	37	143	3	C0424605
Disease	Paroxysmal atrial fibrillation	HSPG2 NEBL UBE4B ARNT2 HERC1	1.00e-03	156	143	5	C0235480
Disease	familial atrial fibrillation	HSPG2 NEBL UBE4B ARNT2 HERC1	1.00e-03	156	143	5	C3468561
Disease	Persistent atrial fibrillation	HSPG2 NEBL UBE4B ARNT2 HERC1	1.00e-03	156	143	5	C2585653
Disease	PRADER-WILLI SYNDROME	MAGEL2 HERC2	1.02e-03	10	143	2	176270
Disease	Prader-Willi syndrome	MAGEL2 HERC2	1.02e-03	10	143	2	cv:C0032897
Disease	osteoarthritis, knee	GLIS3 BABAM2 RNF32-DT CRBN SMG6	1.06e-03	158	143	5	EFO_0004616
Disease	Atrial Fibrillation	HSPG2 NEBL UBE4B ARNT2 HERC1	1.12e-03	160	143	5	C0004238
Disease	Leukoencephalopathy	COL4A1 TCN2	1.25e-03	11	143	2	C0270612
Disease	Enzymopathy	GSR GSS	1.25e-03	11	143	2	C0520572
Disease	Royer Syndrome	MAGEL2 HERC2	1.49e-03	12	143	2	C0265222
Disease	Anemia, Hemolytic, Acquired	COL4A1 GSR	1.76e-03	13	143	2	C0002879
Disease	Anemia, Hemolytic	COL4A1 GSR	1.76e-03	13	143	2	C0002878
Disease	Anemia, Microangiopathic	COL4A1 GSR	1.76e-03	13	143	2	C0002889
Disease	Microangiopathic hemolytic anemia	COL4A1 GSR	1.76e-03	13	143	2	C0221021
Disease	Prader-Willi Syndrome	MAGEL2 HERC2	1.76e-03	13	143	2	C0032897
Disease	Childhood Ataxia with Central Nervous System Hypomyelinization	COL4A1 TCN2	2.04e-03	14	143	2	C1858991
Disease	Neoplasm of uncertain or unknown behavior of bladder	TSC1 MTOR	2.35e-03	15	143	2	C0496930
Disease	Benign neoplasm of bladder	TSC1 MTOR	2.35e-03	15	143	2	C0154017
Disease	Carcinoma in situ of bladder	TSC1 MTOR	2.35e-03	15	143	2	C0154091
Disease	free androgen index	UBE4B SLC22A11 GLIS3 ZNF385B C2orf74 DOCK5 QKI	2.38e-03	374	143	7	EFO_0007005
Disease	T-Cell Lymphoma	KMT2D MGA	2.68e-03	16	143	2	C0079772
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	TSC1 MTOR	2.68e-03	16	143	2	DOID:0110861 (implicated_via_orthology)
Disease	vital capacity	HSPG2 DENND2A TCF20 GLIS3 C16orf96 TRIP12 KCNH3 FANCE DST PLAG1 KDM2A SLC14A2 RNF32-DT SMG6	2.79e-03	1236	143	14	EFO_0004312
Disease	insulin resistance	DOCK1 CDKAL1 MTOR	2.97e-03	59	143	3	EFO_0002614
Disease	uric acid measurement	SLC22A11 B4GALT1 DUS2 CPEB4 SIK2 SFXN2 AGMAT SLC14A2 RNF32-DT	3.00e-03	610	143	9	EFO_0004761
Disease	Carcinoma of bladder	TSC1 MTOR	3.39e-03	18	143	2	C0699885
Disease	intraocular pressure measurement	COL4A1 PRTG GLIS3 BABAM2 ELMO3 MTOR HERC2 SMG6	3.47e-03	509	143	8	EFO_0004695
Disease	testosterone measurement	YIPF4 POLR2A SLC22A11 PSD3 GLIS3 WDR81 XDH C16orf96 ZNF385B GSS DOCK5 GYS1 CPEB4 RNF32-DT	3.68e-03	1275	143	14	EFO_0004908
Disease	prion disease	ATRIP CPEB4	3.78e-03	19	143	2	EFO_0004720
Disease	DiGeorge syndrome (implicated_via_orthology)	DOCK1 DICER1	3.78e-03	19	143	2	DOID:11198 (implicated_via_orthology)
Disease	hematocrit	ASNSD1 ACO1 TRMT112 GLIS3 HLCS ITGB6 PHGDH CDKAL1 B4GALT1 AGMAT EMC10 SLC14A2	3.85e-03	1011	143	12	EFO_0004348
Disease	serum IgG glycosylation measurement	DOCK2 ACO1 B4GALT1 SLC38A10 ALKBH8 COMMD10 HRH1 CRBN	4.08e-03	523	143	8	EFO_0005193
Disease	body surface area	TRIP12 DICER1 DOCK5 KCNE4 MTOR PA2G4 PLAG1 KDM2A SYMPK	4.22e-03	643	143	9	EFO_0022196
Disease	cardiovascular system disease (is_implicated_in)	XDH GYS1	4.61e-03	21	143	2	DOID:1287 (is_implicated_in)
Disease	coronary atherosclerosis measurement, traffic air pollution measurement	DOCK1 NEBL	4.61e-03	21	143	2	EFO_0007908, EFO_0007938

Protein segments in the cluster

Peptide	Gene	Start	Entry
AEAVMLGQPISMVLP	ACO1	226	P21399
MLPTVLRMAGDPVAN	PPP2R1A	521	P30153
LFTMDRVLTPPMGTV	TGFBI	491	Q15582
QMLRMLLSPGGVSQP	CCDC137	226	Q6PK04
PSPIGSTRMLQLMTI	SMG6	931	Q86US8
LIMIIPPMFGAVQSV	ACER3	41	Q9NUN7
MRLREPLLSGSAAMP	B4GALT1	1	P15291
MSTRQFERTPPIMGI	ATG13	196	O75143
RAMSVLMIPIAATVP	COX18	261	Q8N8Q8
MLSRIPPVAARLQMS	CHD5	1881	Q8TDI0
SVPLLMPLVTLMERQ	BCAR3	706	O75815
PVMLPRRSLLVMTGE	ALKBH8	271	Q96BT7
EVSMVTAVPGRLPVM	GSR	306	P00390
QVMMILIPGQTLPLQ	CRBN	86	Q96SW2
TVPLLGAMMLLESPI	APMAP	51	Q9HDC9
MAHVTGRVLPAPMLQ	AGO3	406	Q9H9G7
EMTELTGRVLPAPML	AGO4	396	Q9HCK5
LQPLSMAGLQLMTPA	DICER1	6	Q9UPY3
TIPIAPDMRGQATMV	ATP8A2	1051	Q9NTI2
TLPVAPMAATGQVRM	ARNT2	21	Q9HBZ2
MSMAPITGENIRPFI	COL4A1	1531	P02462
MLASPARPTLRMLAN	RNF32-DT	1	Q8NI28
TLMVLELAPPTQRLM	RAD21L1	321	Q9H4I0
MLEPVQRPDVVLMGA	HSPG2	626	P98160
IMPLIRQIQTAVMPN	QKI	251	Q96PU8
RMGPRSPSVIFMINL	P2RY8	51	Q86VZ1
MPAMRGLLAPQNTFL	KCNH3	1	Q9ULD8
FTVLLMPNGPMRITS	PA2G4	321	Q9UQ80
LQLIMMVLGTPSPAV	MAPK7	271	Q13164
ILVAVASMPSRQPML	OR10AC1	46	Q8NH08
VSGLRSVQVPLMLNM	KCNE4	141	Q8WWG9
SELQAPPLMGTVVMA	MAD2L1BP	201	Q15013
GVLMAQPLTPGVLMV	MAGEL2	236	Q9UJ55
RMVLQPVRSPSGMNL	MGA	1786	Q8IWI9
LVAPISLMMLNPIGF	GPR155	171	Q7Z3F1
VPALPIVVQLMEMGF	HERC2	2456	O95714
LMVSVLGPLSIDPNM	DST	4646	Q03001
ESPGVMPLSLLRQMF	HERC1	2671	Q15751
ELPGPRMSMTSILTR	LMOD2	336	Q6P5Q4
PTTMRLLDGLMFQTP	HLCS	476	P50747
MAVPAALILRESPSM	COMMD10	1	Q9Y6G5
VNTPSPRLAAMMLLQ	PINK1	331	Q9BXM7
PNIPMIMLGVSLAIL	ITGB6	706	P18564
RIMGDLMRTMPILSP	NUP85	231	Q9BW27
LMRTMPILSPGNTQT	NUP85	236	Q9BW27
MPNLTPLVGLEELEM	LRRC4	211	Q9HBW1
RMEMQPTLTDLPLLP	LRRC46	226	Q96FV0
LSVQASLMTPVQPML	LIG3	471	P49916
MAPMGIRLSPLGVAV	BPNT2	1	Q9NX62
HMRQLLMDRGLPVIP	ALAS2	456	P22557
MAPEIVNIVEPMVGL	PTPRQ	501	Q9UMZ3
PMTMDRITALPTGVL	PRTG	176	Q2VWP7
APRLPSTMLLMNLAA	F2RL3	106	Q96RI0
IVPPQGTMFVLEMRD	ITPRIPL1	241	Q6GPH6
LNRQEIPPTLLMGMR	CPT1C	286	Q8TCG5
LLMILSAMAVTRFPP	GASK1A	21	Q9UFP1
DVHTRLQMPVLGMTP	DPYSL4	71	O14531
AVSNMLPVIVGPLVM	FAXDC2	226	Q96IV6
MVVLSVRPMEPIITN	IGSF5	76	Q9NSI5
SMLQLIHDPVSPRGM	KDM2A	721	Q9Y2K7
PLPTRTEGVIDMRSM	KCNB1	571	Q14721
PLSMLLNGIVDPAVM	DOCK1	1521	Q14185
PLSMLLNGIVDPAVM	DOCK2	1526	Q92608
PLSMLLSGIVDPAVM	DOCK5	1546	Q9H7D0
GVPRPLRAVELAMIM	CPEB2	446	Q7Z5Q1
MSPEVALNRISPMLS	BABAM2	1	Q9NXR7
DRPVEMMTGPQLITI	C16orf96	916	A6NNT2
SPALVQPLMRSVMEA	DENND2A	691	Q9ULE3
VIPEGAMLRLGMTNP	CDKAL1	281	Q5VV42
AMLRLGMTNPPYILE	CDKAL1	286	Q5VV42
AAPNLSRMGAIPVMI	CXADR	341	P78310
SRMGAIPVMIPAQSK	CXADR	346	P78310
MMVQRLGLISPPASQ	GLIS3	1	Q8NEA6
MNLNVPMRPGILVQR	C2orf74	76	A8MZ97
IRMQSPVDVIRSPTM	GALNT12	296	Q8IXK2
QALMLGLLEPRMRTP	ELMO3	286	Q96BJ8
AMKRGLISTPPSDML	BTBD7	536	Q9P203
VVPLNMMLPQAALET	ASNSD1	241	Q9NWL6
GPMQMRLIPTLVSIM	IPO9	641	Q96P70
ILMMLLNRYSEPPGS	CUL9	916	Q8IWT3
GVPRPLRAVELAMIM	CPEB4	586	Q17RY0
IPVVLFLMMSGAPDT	EMC10	231	Q5UCC4
RNLMSLLMAVRPSLP	FANCE	96	Q9HB96
TMASPQLMPLVVVLS	HRH1	21	P35367
VMPGVSMLIRGLPDV	ATRIP	751	Q8WXE1
LAPMVRVGTLPMRLL	DUS2	16	Q9NX74
PMGLVTPNIMLSIDR	CELSR3	2316	Q9NYQ7
ALIAIPMSSQTPRML	DNAJC9-AS1	121	A6NH13
MLEMLLPGQPEAVAR	GSS	316	P48637
MPLNRTLSMSSLPGL	GYS1	1	P13807
AMMGPLILMSRQALP	SLC22A11	476	Q9NSA0
TMNISLPGEMVTLGP	SLC15A1	406	P46059
PMMILPCRQALSTLL	SLC38A10	286	Q9HBR0
STSLLGSMFPMPRVI	SLC7A3	346	Q8WY07
SIIPMLTGEVIPVME	C9orf72	171	Q96LT7
MPRTLDGQITMEKTP	HS3ST6	141	Q96QI5
VMTPMLNPLIYSLRN	OR13C8	286	Q8NGS7
LEPLHAMMERGPQTL	MTOR	2051	P42345
MPRPGTMALCLLTLV	MUC17	1	Q685J3
PLTRMPLSVMLVVSS	MUC17	276	Q685J3
PPGRLSMMSFILNAL	SYS1	61	Q8N2H4
PRPAIVVLLMSMVNE	USO1	361	O60763
SRPPLVVFMISVSAM	TMEM248	16	Q9NWD8
SRITMSAPGMILLPV	SFXN2	231	Q96NB2
SAPGMILLPVIMERL	SFXN2	236	Q96NB2
MIQVLDPRPLTSSVM	PPP1R3C	6	Q9UQK1
PEEMPITVLQSMKLG	STRIP2	546	Q9ULQ0
EMLLPMGLPENVSVI	FARSA	441	Q9Y285
LGFLEIETPMMNIIP	KARS1	261	Q15046
SSPTMMPRLRAIQLT	MAP3K21	546	Q5TCX8
VSLSSEAMPMVRIVP	OPLAH	216	O14841
SRPLMVLTEFMELGP	EPHB6	741	O15197
VGLPVTMHSPNMRLL	SIK2	371	Q9H0K1
ARPVGVCSMMRLPVQ	AGMAT	51	Q9BSE5
GVRPSPMQLELRMVQ	PDXK	281	O00764
MQMSLSLLPPTALVG	SEC23A	151	Q15436
TPLALQFLMTSPMRG	TCN2	246	P20062
LEMGPPQRLMVNSAV	C11orf16	351	Q9NQ32
QMITTLPLGMTCPID	PLAG1	306	Q6DJT9
TGVLVLITMLPMIPQ	TSC1	131	Q92574
RLMLLNMPGQLPQTL	TSC1	316	Q92574
LVMGPPMLQEISNLF	TMEM35B	76	Q8NCS4
PRMQVTISVTSPLMR	ZFR2	726	Q9UPR6
MMAAALGPPEVIAQL	XPO4	1	Q9C0E2
IMMGFEPLVNQRLLP	NAA35	296	Q5VZE5
PMGLIIMPGMISRAL	SLC5A10	311	A0PJK1
MFPISRGIPNMLLSE	TRMT112	106	Q9UI30
QELAMVPRMIVTPQS	POLR2A	516	P24928
LMDTLMTDPVRLPSG	UBE4B	1236	O95155
VPQVRVSVMPMLLLA	TMEM115	161	Q12893
VMSMYTLLRNQPEPT	XDH	121	P47989
NMRSPVMSTLLPSLR	PPP1R36	311	Q96LQ0
IIRNALPIGRMPIML	POLR3B	126	Q9NW08
LPIGRMPIMLRSSNC	POLR3B	131	Q9NW08
NLNMPPLRDGARVLM	USP9Y	1031	O00507
TTLPALVRTPTLMMQ	ZNF385B	91	Q569K4
LVRTPTLMMQPSLDI	ZNF385B	96	Q569K4
GSVPMGSRNRILQLM	TCF20	401	Q9UGU0
VLSARPTMSPTEMLR	nan	91	Q6ZWC4
PLSELGKETIMLMTP	SNX19	376	Q92543
QSPLPMLLMRTVIQS	SYMPK	991	Q92797
QTSDPAMLPTMIGLL	PHGDH	471	O43175
LMPMPSLGFNRQVVR	YIPF4	96	Q9BSR8
QVHGPEMLARGMVPL	ZKSCAN1	146	P17029
LTVLNPMKPVDGSIM	YIPF7	131	Q8N8F6
PVAVSMAQPLAGITM	ZC3H10	396	Q96K80
PISPMALTMLNGLLI	ZSWIM1	26	Q9BR11
LVVTPPILSSGMFIM	TRIP12	656	Q14669
EMEMPLLLQAIPVGV	SLC14A2	276	Q15849
MPLTPMIQQRIKEGG	PSD3	476	Q9NYI0
RQLRNPPTTIGMMTL	TERF2	316	Q15554
VLDTLLQMSGPEVPM	WDR81	821	Q562E7
PTMPLLAMLLRGLTQ	GEMIN4	211	P57678
LMELPLMINPTGCAR	KMT2D	5326	O14686
QMKGRPSLILDTPAM	NEBL	756	O76041