Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	PRAMEF9 KLHL40 PRAMEF15 ENC1 FBXL15 KLHL41 PRAMEF4 FBXL21P FBXL7 BUB1B	1.66e-07	212	109	10	GO:0031461
GeneOntologyCellularComponent	ubiquitin ligase complex	PRAMEF9 KLHL40 PRAMEF15 ENC1 FBXL15 KLHL41 PRAMEF4 FBXL21P FBXL7 BUB1B OS9	2.33e-06	352	109	11	GO:0000151
GeneOntologyCellularComponent	keratin filament	KRTAP16-1 KRTAP4-8 KRTAP4-11 KRTAP4-6 KRTAP4-9	1.55e-04	97	109	5	GO:0045095
GeneOntologyCellularComponent	transferase complex	CCNL2 PRAMEF9 KLHL40 PRAMEF15 ENC1 FBXL15 ATG14 CCND1 KLHL41 PRAMEF4 FBXL21P FBXL7 BUB1B OS9	4.81e-04	963	109	14	GO:1990234
Domain	MRGPCRFAMILY	MAS1 MRGPRE MRGPRG MRGPRX3	3.51e-07	11	109	4	IPR026234
Domain	KAP	KRTAP16-1 KRTAP4-7 KRTAP4-8 KRTAP4-11 KRTAP4-6 KRTAP4-9	1.09e-06	58	109	6	IPR002494
Domain	Keratin_B2	KRTAP4-7 KRTAP4-8 KRTAP4-11 KRTAP4-6 KRTAP4-9	3.45e-06	40	109	5	PF01500
Domain	zf-C2H2_11	ZNF532 ZNF592 ZNF687	1.58e-05	9	109	3	PF16622
Domain	LRR_6	CARMIL2 FBXL15 NLRP14 FBXL7 LRRC74B	1.70e-05	55	109	5	PF13516
Domain	EIF3C_N_dom	EIF3CL EIF3C	3.37e-05	2	109	2	IPR008905
Domain	eIF-3c_N	EIF3CL EIF3C	3.37e-05	2	109	2	PF05470
Domain	PD736990	DEFB112 DEFB110	3.37e-05	2	109	2	PD736990
Domain	EIF3C	EIF3CL EIF3C	3.37e-05	2	109	2	IPR027516
Domain	Keratin_B2_2	KRTAP16-1 KRTAP4-8 KRTAP4-11 KRTAP4-6	7.71e-05	39	109	4	PF13885
Domain	IQSEC_PH	IQSEC3 IQSEC2	1.01e-04	3	109	2	IPR033742
Domain	IQ_SEC7_PH	IQSEC3 IQSEC2	1.01e-04	3	109	2	PF16453
Domain	BTB-kelch_protein	KLHL40 ENC1 KLHL41 IVNS1ABP	1.14e-04	43	109	4	IPR017096
Domain	Kelch	KLHL40 ENC1 KLHL41 IVNS1ABP	3.65e-04	58	109	4	SM00612
Domain	BACK	KLHL40 ENC1 KLHL41 IVNS1ABP	4.16e-04	60	109	4	SM00875
Domain	BACK	KLHL40 ENC1 KLHL41 IVNS1ABP	4.43e-04	61	109	4	IPR011705
Domain	BACK	KLHL40 ENC1 KLHL41 IVNS1ABP	4.43e-04	61	109	4	PF07707
Domain	CD59_antigen_CS	LYPD5 GML	4.99e-04	6	109	2	IPR018363
Domain	-	CARMIL2 PRAMEF15 FBXL15 PRAMEF4 FBXL21P NLRP14 FBXL7 LRRC74B	5.89e-04	321	109	8	3.80.10.10
Domain	BTB	KLHL40 ENC1 KLHL41 IVNS1ABP KCNS1 ZBTB11	6.57e-04	180	109	6	SM00225
Domain	L_dom-like	CARMIL2 PRAMEF15 FBXL15 PRAMEF4 FBXL21P NLRP14 FBXL7 LRRC74B	6.79e-04	328	109	8	IPR032675
Domain	Kelch_1	KLHL40 ENC1 KLHL41 IVNS1ABP	7.48e-04	70	109	4	PF01344
Domain	Kelch_1	KLHL40 ENC1 KLHL41 IVNS1ABP	7.48e-04	70	109	4	IPR006652
Domain	BTB/POZ_dom	KLHL40 ENC1 KLHL41 IVNS1ABP KCNS1 ZBTB11	7.58e-04	185	109	6	IPR000210
Domain	Semap_dom	SEMA6C SEMA6D PLXNA1	7.72e-04	31	109	3	IPR001627
Domain	SEMA	SEMA6C SEMA6D PLXNA1	7.72e-04	31	109	3	PS51004
Domain	Sema	SEMA6C SEMA6D PLXNA1	7.72e-04	31	109	3	SM00630
Domain	Sema	SEMA6C SEMA6D PLXNA1	7.72e-04	31	109	3	PF01403
Domain	IQ	IQSEC3 IQSEC2 MYO1F CAMTA1	7.90e-04	71	109	4	PF00612
Domain	SKP1/BTB/POZ	KLHL40 ENC1 KLHL41 IVNS1ABP KCNS1 ZBTB11	8.48e-04	189	109	6	IPR011333
Domain	Plexin_repeat	SEMA6C SEMA6D PLXNA1	8.48e-04	32	109	3	IPR002165
Domain	PSI	SEMA6C SEMA6D PLXNA1	8.48e-04	32	109	3	PF01437
Domain	BTB	KLHL40 ENC1 KLHL41 IVNS1ABP ZBTB11	1.03e-03	131	109	5	PF00651
Domain	Orgcat_transp/SVOP	SLC22A4 SLC22A5	1.18e-03	9	109	2	IPR004749
Domain	IQ_motif_EF-hand-BS	IQSEC3 IQSEC2 MYO1F CAMTA1	1.91e-03	90	109	4	IPR000048
Domain	IQ	IQSEC3 IQSEC2 MYO1F CAMTA1	2.15e-03	93	109	4	PS50096
Domain	PSI	SEMA6C SEMA6D PLXNA1	2.15e-03	44	109	3	IPR016201
Domain	PSI	SEMA6C SEMA6D PLXNA1	2.45e-03	46	109	3	SM00423
Domain	BTB	KLHL40 ENC1 KLHL41 IVNS1ABP ZBTB11	2.47e-03	160	109	5	PS50097
Domain	-	KLHL40 ENC1 KLHL41	2.76e-03	48	109	3	2.120.10.80
Domain	-	IQSEC3 IQSEC2	3.37e-03	15	109	2	1.10.1000.11
Domain	Sec7	IQSEC3 IQSEC2	3.37e-03	15	109	2	PF01369
Domain	Sec7_alpha_orthog	IQSEC3 IQSEC2	3.37e-03	15	109	2	IPR023394
Domain	FBOX	FBXL15 FBXL21P FBXL7	3.47e-03	52	109	3	SM00256
Domain	SEC7	IQSEC3 IQSEC2	3.84e-03	16	109	2	PS50190
Domain	Sec7	IQSEC3 IQSEC2	3.84e-03	16	109	2	SM00222
Domain	Sec7_dom	IQSEC3 IQSEC2	3.84e-03	16	109	2	IPR000904
Domain	PINT	EIF3CL EIF3C	3.84e-03	16	109	2	SM00088
Domain	Kelch-typ_b-propeller	KLHL40 ENC1 KLHL41	4.07e-03	55	109	3	IPR015915
Domain	PCI_dom	EIF3CL EIF3C	4.33e-03	17	109	2	IPR000717
Domain	Cyclin_C-dom	CCNL2 CCND1	4.33e-03	17	109	2	IPR004367
Domain	Cyclin_C	CCNL2 CCND1	4.33e-03	17	109	2	PF02984
Domain	PCI	EIF3CL EIF3C	4.33e-03	17	109	2	PF01399
Domain	Cyclin_C	CCNL2 CCND1	4.33e-03	17	109	2	SM01332
Domain	Gal_Oxase/kelch_b-propeller	KLHL40 ENC1 KLHL41	4.96e-03	59	109	3	IPR011043
Domain	Leu-rich_rpt_Cys-con_subtyp	FBXL15 FBXL7	5.41e-03	19	109	2	IPR006553
Domain	LRR_CC	FBXL15 FBXL7	5.41e-03	19	109	2	SM00367
Domain	PRAME_family	PRAMEF15 PRAMEF4	5.41e-03	19	109	2	IPR026271
Domain	EGF_CA	TPO STAB2 F12 VWA2	5.69e-03	122	109	4	SM00179
Pubmed	Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21.	KRTAP16-1 KRTAP4-7 KRTAP4-8 KRTAP4-11 KRTAP4-6 KRTAP4-9	1.98e-09	37	111	6	11279113
Pubmed	Size polymorphisms in the human ultrahigh sulfur hair keratin-associated protein 4, KAP4, gene family.	KRTAP4-7 KRTAP4-8 KRTAP4-11 KRTAP4-6	6.81e-09	8	111	4	15955084
Pubmed	Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.	SEMA6C SEMA6D PLXNA1	3.15e-07	5	111	3	20512151
Pubmed	Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation.	SEMA6C SEMA6D PLXNA1	6.28e-07	6	111	3	21831918
Pubmed	Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.	MAS1 MRGPRE MRGPRX3	1.75e-06	8	111	3	24583173
Pubmed	Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.	MRGPRE MRGPRG MRGPRX3	1.75e-06	8	111	3	12909716
Pubmed	Control of species-dependent cortico-motoneuronal connections underlying manual dexterity.	SEMA6C SEMA6D PLXNA1	2.62e-06	9	111	3	28751609
Pubmed	Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway.	MRGPRE MRGPRG MRGPRX3	2.62e-06	9	111	3	12397184
Pubmed	A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.	MRGPRE MRGPRG MRGPRX3	5.12e-06	11	111	3	11551509
Pubmed	On and off retinal circuit assembly by divergent molecular mechanisms.	SEMA6C SEMA6D PLXNA1	6.82e-06	12	111	3	24179230
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZMYND8 SETDB1 PTPN13 SALL2 ZNF532 ZNF592 BUB1B ZBTB11 ZNF687	8.24e-06	418	111	9	34709266
Pubmed	Haplotype in the IBD5 region is associated with refractory Crohn's disease in Slovenian patients and modulates expression of the SLC22A5 gene.	SLC22A4 SLC22A5	1.01e-05	2	111	2	21695374
Pubmed	Molecular and functional characterization of organic cation/carnitine transporter family in mice.	SLC22A4 SLC22A5	1.01e-05	2	111	2	11010964
Pubmed	Analysis of the influence of OCTN1/2 variants within the IBD5 locus on disease susceptibility and growth indices in early onset inflammatory bowel disease.	SLC22A4 SLC22A5	1.01e-05	2	111	2	16469794
Pubmed	Gene expression of carnitine organic cation transporters 1 and 2 (OCTN) is downregulated in patients with ulcerative colitis.	SLC22A4 SLC22A5	1.01e-05	2	111	2	21910182
Pubmed	Association of SLC22A4/5 polymorphisms with steroid responsiveness of inflammatory bowel disease in Japan.	SLC22A4 SLC22A5	1.01e-05	2	111	2	18274826
Pubmed	Expression patterns of the organic cation/carnitine transporter family in adult murine brain.	SLC22A4 SLC22A5	1.01e-05	2	111	2	17576045
Pubmed	Substrate discrimination by ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5: gain-of-function by interchange of selected amino acids.	SLC22A4 SLC22A5	1.01e-05	2	111	2	19814996
Pubmed	Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5).	SLC22A4 SLC22A5	1.01e-05	2	111	2	19141711
Pubmed	Contribution of the IBD5 locus to Crohn's disease in the Swedish population.	SLC22A4 SLC22A5	1.01e-05	2	111	2	17340776
Pubmed	Prevalence of SLC22A4 1672T and SLC22A5 -207C combination defined TC haplotype in Hungarian ulcerative colitis patients.	SLC22A4 SLC22A5	1.01e-05	2	111	2	17387389
Pubmed	Expression pattern of ATM and cyclin D1 in ductal carcinoma, normal adjacent and normal breast tissues of Iranian breast cancer patients.	CCND1 ATM	1.01e-05	2	111	2	21850541
Pubmed	EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.	EIF3CL EIF3C	1.01e-05	2	111	2	36157221
Pubmed	Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men.	SLC22A4 SLC22A5	1.01e-05	2	111	2	32964310
Pubmed	Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons.	SLC22A4 SLC22A5	1.01e-05	2	111	2	21606177
Pubmed	Prognostic significance of ATM and cyclin B1 in pancreatic neuroendocrine tumor.	CCND1 ATM	1.01e-05	2	111	2	22707287
Pubmed	Direct or indirect association in a complex disease: the role of SLC22A4 and SLC22A5 functional variants in Crohn disease.	SLC22A4 SLC22A5	1.01e-05	2	111	2	16835882
Pubmed	Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption.	SLC22A4 SLC22A5	1.01e-05	2	111	2	20020740
Pubmed	Identification, characterization, and functional study of the two novel human members of the semaphorin gene family.	SEMA6C SEMA6D	1.01e-05	2	111	2	12110693
Pubmed	[Possible role of selected IGR and SLC22A4/SLC22A5 loci in development of inflammatory bowel diseases].	SLC22A4 SLC22A5	1.01e-05	2	111	2	19581171
Pubmed	Polymorphisms in the organic cation transporter genes SLC22A4 and SLC22A5 and Crohn's disease in a New Zealand Caucasian cohort.	SLC22A4 SLC22A5	1.01e-05	2	111	2	16519742
Pubmed	ATM is required for rapid degradation of cyclin D1 in response to gamma-irradiation.	CCND1 ATM	1.01e-05	2	111	2	19071090
Pubmed	Functional activity of L-carnitine transporters in human airway epithelial cells.	SLC22A4 SLC22A5	1.01e-05	2	111	2	26607009
Pubmed	OCTNs: will the real IBD5 gene please stand up?	SLC22A4 SLC22A5	1.01e-05	2	111	2	16773684
Pubmed	Association of the organic cation transporter OCTN genes with Crohn's disease in the Spanish population.	SLC22A4 SLC22A5	1.01e-05	2	111	2	16333318
Pubmed	Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients.	SLC22A4 SLC22A5	1.01e-05	2	111	2	21793125
Pubmed	Organic cation/carnitine transporter family expression patterns in adult murine heart.	SLC22A4 SLC22A5	1.01e-05	2	111	2	19233567
Pubmed	Expression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium.	SLC22A4 SLC22A5	1.01e-05	2	111	2	18641280
Pubmed	SLC22A4 and SLC22A5 gene polymorphisms and Crohn's disease in the Chinese Han population.	SLC22A4 SLC22A5	1.01e-05	2	111	2	19659785
Pubmed	Characterization of organic cation/carnitine transporter family in human sperm.	SLC22A4 SLC22A5	1.01e-05	2	111	2	12788076
Pubmed	Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis.	SLC22A4 SLC22A5	1.01e-05	2	111	2	21706137
Pubmed	ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis.	CCND1 ATM	1.01e-05	2	111	2	23318439
Pubmed	Evidence for association of OCTN genes and IBD5 with ulcerative colitis.	SLC22A4 SLC22A5	1.01e-05	2	111	2	16361305
Pubmed	Evidence for the association of the SLC22A4 and SLC22A5 genes with type 1 diabetes: a case control study.	SLC22A4 SLC22A5	1.01e-05	2	111	2	16796743
Pubmed	Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons.	SEMA6D PLXNA1	1.01e-05	2	111	2	37344233
Pubmed	Expression and functional analysis of intestinal organic cation/L-carnitine transporter (OCTN) in Crohn's disease.	SLC22A4 SLC22A5	1.01e-05	2	111	2	22325173
Pubmed	Polymorphisms in OCTN1 and OCTN2 transporters genes are associated with prolonged time to progression in unresectable gastrointestinal stromal tumours treated with imatinib therapy.	SLC22A4 SLC22A5	1.01e-05	2	111	2	23127916
Pubmed	LPS-induced inflammation delays the transportation of ASP+ due to down-regulation of OCTN1/2 in alveolar epithelial cells.	SLC22A4 SLC22A5	1.01e-05	2	111	2	31591905
Pubmed	Tagging genes with cassette-exchange sites.	AGO2 DOCK9 ENC1 ZMYND8 EIF3CL HELZ EIF3C PLXNA1	1.27e-05	335	111	8	15741177
Pubmed	Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.	SEMA6C SEMA6D PLXNA1	1.72e-05	16	111	3	22632726
Pubmed	Sema6B, Sema6C, and Sema6D expression and function during mammalian retinal development.	SEMA6C SEMA6D	3.02e-05	3	111	2	23646199
Pubmed	A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease.	SLC22A4 SLC22A5	3.02e-05	3	111	2	15685536
Pubmed	Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents.	BUB1B ATM	3.02e-05	3	111	2	34545188
Pubmed	Functional variants of OCTN cation transporter genes are associated with Crohn disease.	SLC22A4 SLC22A5	3.02e-05	3	111	2	15107849
Pubmed	Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization.	SEMA6D PLXNA1	3.02e-05	3	111	2	29777213
Pubmed	Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease.	SLC22A4 SLC22A5	3.02e-05	3	111	2	16771961
Pubmed	Polymorphisms in the IBD5 locus are associated with Crohn disease in pediatric Ashkenazi Jewish patients.	SLC22A4 SLC22A5	3.02e-05	3	111	2	19412005
Pubmed	Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis.	SLC22A4 SLC22A5	3.02e-05	3	111	2	16255050
Pubmed	SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes.	CCND1 SALL2	3.02e-05	3	111	2	29689621
Pubmed	Expression of the organic cation/carnitine transporter family (Octn1,-2 and-3) in mdx muscle and heart: Implications for early carnitine therapy in Duchenne muscular dystrophy to improve cellular carnitine homeostasis.	SLC22A4 SLC22A5	3.02e-05	3	111	2	32070725
Pubmed	Variants of OCTN1-2 cation transporter genes are associated with both Crohn's disease and ulcerative colitis.	SLC22A4 SLC22A5	3.02e-05	3	111	2	16441470
Pubmed	IGR2096a_1 T and IGR2198a_1 C alleles on IBD5 locus of chromosome 5q31 region confer risk for Crohn's disease in Hungarian patients.	SLC22A4 SLC22A5	3.02e-05	3	111	2	19214536
Pubmed	The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease.	SLC22A4 SLC22A5	3.02e-05	3	111	2	16344054
Pubmed	OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease.	SLC22A4 SLC22A5	3.02e-05	3	111	2	18756601
Pubmed	BRCA1-IRIS activates cyclin D1 expression in breast cancer cells by downregulating the JNK phosphatase DUSP3/VHR.	DUSP3 CCND1	3.02e-05	3	111	2	17278098
Pubmed	Role of SLC22A4, SLC22A5, and RUNX1 genes in rheumatoid arthritis.	SLC22A4 SLC22A5	3.02e-05	3	111	2	16652416
Pubmed	Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.	SLC22A4 SLC22A5	3.02e-05	3	111	2	15955786
Pubmed	Phosphorylation of cyclin D1 regulated by ATM or ATR controls cell cycle progression.	CCND1 ATM	3.02e-05	3	111	2	18606783
Pubmed	Lack of association between IBD5 and Crohn's disease in Japanese patients demonstrates population-specific differences in inflammatory bowel disease.	SLC22A4 SLC22A5	3.02e-05	3	111	2	16373276
Pubmed	Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.	SLC22A4 SLC22A5	3.02e-05	3	111	2	33124720
Pubmed	Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn's disease.	SLC22A4 SLC22A5	3.02e-05	3	111	2	17006998
Pubmed	Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs.	AGO2 TRIM71	3.02e-05	3	111	2	33599613
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	SLC25A33 ZMYND8 IVNS1ABP MFGE8 PTPN13 OS9 ALG3	4.81e-05	296	111	7	34186245
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SEMA6C AGO2 CAPN10 IVNS1ABP FBXL7 ZNF532 ZNF592 MED12L ZNF687	5.21e-05	529	111	9	14621295
Pubmed	Role of CARD15, DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases.	SLC22A4 SLC22A5	6.03e-05	4	111	2	17451203
Pubmed	Risk factors for perianal Crohn's disease: the role of genotype, phenotype, and ethnicity.	SLC22A4 SLC22A5	6.03e-05	4	111	2	17509030
Pubmed	rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.	SLC22A4 SLC22A5	6.03e-05	4	111	2	17786191
Pubmed	Runt-related transcription factor 3 is associated with ulcerative colitis and shows epistasis with solute carrier family 22, members 4 and 5.	SLC22A4 SLC22A5	6.03e-05	4	111	2	18668679
Pubmed	Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease.	SLC22A4 SLC22A5	6.03e-05	4	111	2	16437728
Pubmed	Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.	EIF3CL EIF3C	6.03e-05	4	111	2	10504338
Pubmed	Transport of gabapentin by LAT1 (SLC7A5).	SLC22A4 SLC22A5	6.03e-05	4	111	2	23567998
Pubmed	A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5).	SLC22A4 SLC22A5	6.03e-05	4	111	2	12535646
Pubmed	Association of organic cation transporter risk haplotype with perianal penetrating Crohn's disease but not with susceptibility to IBD.	SLC22A4 SLC22A5	6.03e-05	4	111	2	16344053
Pubmed	Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2.	SEMA6D PLXNA1	6.03e-05	4	111	2	14977921
Pubmed	Relationship between CARD15, SLC22A4/5, and DLG5 polymorphisms and early-onset inflammatory bowel diseases: an Italian multicentric study.	SLC22A4 SLC22A5	6.03e-05	4	111	2	16670523
Pubmed	Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.	SEMA6D PLXNA1	6.03e-05	4	111	2	16715077
Pubmed	Streamlined analysis schema for high-throughput identification of endogenous protein complexes.	ZMYND8 INTS3 ZNF592 ZNF687	8.10e-05	71	111	4	20133760
Pubmed	Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease.	SLC22A4 SLC22A5	1.00e-04	5	111	2	17476680
Pubmed	The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population.	SLC22A4 SLC22A5	1.00e-04	5	111	2	18162085
Pubmed	A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9.	CCND1 SETDB1	1.00e-04	5	111	2	19010785
Pubmed	Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy.	SLC22A4 SLC22A5	1.00e-04	5	111	2	18698678
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	GPR20 MRGPRE MRGPRG ADGRL3	1.23e-04	79	111	4	12679517
Pubmed	Lack of evidence for association of primary sclerosing cholangitis and primary biliary cirrhosis with risk alleles for Crohn's disease in Polish patients.	SLC22A4 SLC22A5	1.50e-04	6	111	2	18715515
Pubmed	Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk.	SLC22A4 SLC22A5	1.50e-04	6	111	2	18433468
Pubmed	Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease.	SLC22A4 SLC22A5	1.50e-04	6	111	2	17213842
Pubmed	Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.	ENC1 KLHL41	1.50e-04	6	111	2	19424503
Pubmed	PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2.	SLC22A4 SLC22A5	1.50e-04	6	111	2	15523054
Pubmed	ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.	SETDB1 MYO1F	1.50e-04	6	111	2	27732843
Pubmed	The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein.	AGO2 TRIM71	1.50e-04	6	111	2	24602972
Pubmed	Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor.	MAS1 F12	1.50e-04	6	111	2	25339356
Cytoband	17q21.2	KRTAP16-1 KRTAP4-7 KRTAP4-8 KRTAP4-11 KRTAP4-9	8.06e-07	70	111	5	17q21.2
Cytoband	11p15.4	MRGPRE NLRP14 OR52H1 MRGPRG OR2AG1	1.32e-04	200	111	5	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	DUSP3 KRTAP16-1 KRTAP4-7 KRTAP4-8 KRTAP4-11 KRTAP4-6 KRTAP4-9	1.59e-04	473	111	7	chr17q21
Cytoband	1p36.21	PRAMEF9 PRAMEF15 PRAMEF4	4.91e-04	63	111	3	1p36.21
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	CCNL2 PRAMEF9 SLC25A33 PRAMEF15 PRAMEF4 SCNN1D CAMTA1	1.38e-03	681	111	7	chr1p36
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	MRGPRE NLRP14 OR52H1 MRGPRG MRGPRX3 OR2AG1	2.56e-03	564	111	6	chr11p15
GeneFamily	G protein-coupled receptors, Class A orphans	GPR15 GPR20 MAS1 MRGPRE MRGPRG MRGPRX3	2.32e-06	78	89	6	262
GeneFamily	Keratin associated proteins	KRTAP16-1 KRTAP4-7 KRTAP4-8 KRTAP4-11 KRTAP4-6 KRTAP4-9	1.62e-05	109	89	6	619
GeneFamily	Kelch like\|BTB domain containing	KLHL40 ENC1 KLHL41 IVNS1ABP	5.32e-05	42	89	4	617
GeneFamily	F-box and leucine rich repeat proteins	FBXL15 FBXL21P FBXL7	1.44e-04	21	89	3	558
GeneFamily	PRAME family	PRAMEF9 PRAMEF15 PRAMEF4	2.17e-04	24	89	3	686
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL40 ENC1 KLHL41 IVNS1ABP ZBTB11	5.23e-04	134	89	5	861
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA6C SEMA6D	4.30e-03	20	89	2	736
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENC1 KRTAP4-7 KRTAP4-8 KCNS1 KRTAP4-6 XAF1 KRTAP4-9 UBASH3B	1.39e-09	133	109	8	f7d0763b5eec2db33044d6850fd57462494038c1
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL4A2 GFRA1 CNNM1 FBXL7 SEMA6D UBASH3B	5.43e-06	180	109	6	01f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A2 FBXL21P FBXL7 SEMA6D UBASH3B CA8	6.96e-06	188	109	6	8268574584e5fb869a6cb8bbd7135cd7454a6a25
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A2 FBXL7 SEMA6D UBASH3B GDF11 CA8	7.18e-06	189	109	6	222e67d3fd106c43b0cae6538dddeaa7be1f759f
ToppCell	Tracheal-10x5prime-Stromal-Pericyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL4A2 GPR20 KLHL40 ADAMTS12 MFGE8 SEMA6D	9.63e-06	199	109	6	cefc3b50f65e95da850e4720c7b44bf584073491
ToppCell	Tracheal-10x5prime-Stromal-Pericyte-Muscle_pericyte_systemic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL4A2 GPR20 KLHL40 ADAMTS12 MFGE8 SEMA6D	9.63e-06	199	109	6	aaa460c389cd6d38a13ba1a446f91a94f9573ad8
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Prlr-Inhibitory_Gad1Gad2_Id2.Prlr_(Interneuron,_Neurogliaform3)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TPO GPR15 KLHL41 CA8	1.01e-05	55	109	4	948f26841f18d2d45f74c7c0c7b5be10737a4f43
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Prlr\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TPO GPR15 KLHL41 CA8	1.01e-05	55	109	4	616be3c334949ab0264293b9771d494381d74fb4
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Prlr-Inhibitory_Gad1Gad2_Id2.Prlr_(Interneuron,_Neurogliaform3)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TPO GPR15 KLHL41 CA8	1.01e-05	55	109	4	ed14bdb80cf2ff171b0dfc391ac0b150da344992
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-6\|TCGA-Skin / Sample_Type by Project: Shred V9	KRTAP16-1 KRTAP4-8 KRTAP4-11 KRTAP4-6 KRTAP4-9	2.99e-05	146	109	5	522c32103c24fc26836bb5b642083904682d9292
ToppCell	droplet-Marrow-BM-1m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AGO2 DUSP3 IQSEC2 PTPN13 SLC22A5	5.84e-05	168	109	5	2e88d9cb7c80a4656fab290db8b45a5a0599d769
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 MAS1 GFRA1 PTPN13 ADGRL3	6.89e-05	174	109	5	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CCND1 CNNM1 MED12L UBASH3B VWA2	6.89e-05	174	109	5	46bd0ef7d0541386de7a901d85d53d0176dc92bf
ToppCell	facs-Heart-RV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQSEC3 GPR20 MFGE8 SEMA6D KRTAP4-9	7.08e-05	175	109	5	bfac175b79bb7d3d81074a2407c206a7647ee75d
ToppCell	facs-Heart-RV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQSEC3 GPR20 MFGE8 SEMA6D KRTAP4-9	7.08e-05	175	109	5	c94fb35bbac95123201ca87ca835aecaefc0c490
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Pericytes\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	COL4A2 GPR20 ADAMTS12 MFGE8 ADGRL3	7.28e-05	176	109	5	2015539c58aa0bb118e111ffedd63dd9fe863bb1
ToppCell	facs-SCAT\|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRGPRG CCL7 XAF1 PLXNA1 CA8	8.09e-05	180	109	5	6c70b6b7480507fa94625013222ad338ee7dd1d9
ToppCell	COVID-19_Mild-CD4+_T_activated\|COVID-19_Mild / Disease condition and Cell class	AGO2 CARMIL2 EIF3CL XAF1 EIF3C	8.52e-05	182	109	5	877b6e611626628e709568747512f2827ebb2795
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COL4A2 TPO MFGE8 FBXL7 ADGRL3	8.52e-05	182	109	5	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	Pericytes-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	COL4A2 GPR20 ADAMTS12 MFGE8 ADGRL3	8.75e-05	183	109	5	d04deef7cd4e1738227a6593b84874ce0168c773
ToppCell	COVID-19-Heart-EC_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TPO DOCK9 FBXL7 TBCD CA8	8.75e-05	183	109	5	ff95382cfed592190d0636d2b750328471f82e0d
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_A\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ENC1 LYPD5 HELZ ATM ZNF844	9.20e-05	185	109	5	25781cf68e693e97dc1885e2879ab24fa946b51e
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A2 STAB2 MID2 SALL2 FBXL7	9.44e-05	186	109	5	2cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	COL4A2 ADAMTS12 PTPN13 SEMA6D ADGRL3	9.44e-05	186	109	5	cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A2 FBXL7 SEMA6D UBASH3B CA8	9.44e-05	186	109	5	77592a6397b44b2b59a4fc39d7224dd95343efe6
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A2 STAB2 MID2 SALL2 FBXL7	9.44e-05	186	109	5	90d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell	Pericytes-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	COL4A2 GPR20 ADAMTS12 SEMA6D ADGRL3	9.93e-05	188	109	5	f16ff998393bf1954bbf10caab15173bdb104ac1
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A2 FBXL7 SEMA6D UBASH3B CA8	9.93e-05	188	109	5	4544552ebd67e9eb3e40d8511bb2b03a6e1178f8
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 MFGE8 PTPN13 ZNF532 ADGRL3	9.93e-05	188	109	5	997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A2 FBXL7 SEMA6D UBASH3B CA8	9.93e-05	188	109	5	3139540a656c0436b2123ea50741ff8d00112165
ToppCell	COVID-19-Heart-EC_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TPO DOCK9 FBXL7 TBCD CA8	1.02e-04	189	109	5	fe49852ba15f948b384d6b4c258927c70b741357
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A2 FBXL7 SEMA6D UBASH3B CA8	1.04e-04	190	109	5	2f54da2bee411f8868348a4c37034184b8f58a89
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A2 FBXL7 SEMA6D UBASH3B CA8	1.04e-04	190	109	5	59720dfe9de1b980807644536c919d2a02ba69dd
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	COL4A2 GFRA1 MFGE8 FBXL7 ADGRL3	1.04e-04	190	109	5	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GPR20 ADAMTS12 MFGE8 FBXL7 ADGRL3	1.04e-04	190	109	5	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	COVID-19-Heart-EC_3\|Heart / Disease (COVID-19 only), tissue and cell type	TPO DOCK9 XAF1 TBCD CA8	1.04e-04	190	109	5	78e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCell	COVID-19-Heart-Mito_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TPO KLHL40 KLHL41 FBXL7 CA8	1.04e-04	190	109	5	ea74e0e38bcaba125b48c88331e9ba09228d3178
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 GPR20 MFGE8 FBXL7 ADGRL3	1.07e-04	191	109	5	04c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	COL4A2 ADAMTS12 PTPN13 SEMA6D ADGRL3	1.07e-04	191	109	5	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A2 FBXL21P FBXL7 UBASH3B PLXNA1	1.10e-04	192	109	5	342842378c20267c5044bdd622515e8b9f895623
ToppCell	EC-Sinusoidal_ECs\|EC / Lineage and Cell class	COL4A2 STAB2 ENC1 TSPAN3 SEMA6D	1.12e-04	193	109	5	1291b1d3494dcb4b9309f8bff63fb662e7eca0c8
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A2 STAB2 DUSP3 CCND1 CA8	1.12e-04	193	109	5	2483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A2 STAB2 DUSP3 MFGE8 SEMA6D	1.15e-04	194	109	5	c8b9551b93a5aed62154b487db90130604a6125c
ToppCell	COVID-19-lung-Pericytes/_Smooth_Muscle\|lung / Disease (COVID-19 only), tissue and cell type	COL4A2 GPR20 MFGE8 SEMA6D ADGRL3	1.15e-04	194	109	5	5e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A2 STAB2 DUSP3 MFGE8 FBXL7	1.18e-04	195	109	5	12ba6d95e42d06b1991b011043c0e3370a7b4131
ToppCell	COVID-19-Heart-EC_1\|Heart / Disease (COVID-19 only), tissue and cell type	TPO DOCK9 XAF1 TBCD CA8	1.18e-04	195	109	5	50a193475db1bb1e05b8590225a553688c372c14
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GPR20 ADAMTS12 MFGE8 FBXL7 ADGRL3	1.21e-04	196	109	5	b8759e6231e0254797d6c30930407b79440c57bb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 ADAMTS12 MFGE8 FBXL7 ADGRL3	1.21e-04	196	109	5	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 ADAMTS12 MFGE8 FBXL7 ADGRL3	1.21e-04	196	109	5	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	Endothelial\|World / Lineage, Cell type, age group and donor	COL4A2 STAB2 DOCK9 FBXL7 ADGRL3	1.21e-04	196	109	5	96c6d78482a130ce4e29f6629972a06d10d7530e
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 GPR20 GFRA1 MFGE8 ADGRL3	1.24e-04	197	109	5	ea746772adb9df4ddb0508d4ef35f2027bf09c35
ToppCell	severe-unassigned\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TPO DIS3L DOCK9 TRIM71 MED12L	1.24e-04	197	109	5	70704b149b2820b8601d2495b7cd9cbe91eda262
ToppCell	LV-09._Endothelium_I\|LV / Chamber and Cluster_Paper	TPO DOCK9 XAF1 TBCD CA8	1.24e-04	197	109	5	f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 ADAMTS12 MFGE8 FBXL7 ADGRL3	1.27e-04	198	109	5	79576525a10ed3e3a9d1608077cd16ecda23376f
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	COL4A2 FBXL7 SEMA6D UBASH3B CA8	1.33e-04	200	109	5	ca5401b76ab014080914bf78042d368cf318effa
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1--L2-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	COL4A2 FBXL7 SEMA6D UBASH3B CA8	1.33e-04	200	109	5	70c47d3bbe67d88c5b9dff99c33a603d25fa2ab0
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	COL4A2 FBXL7 SEMA6D UBASH3B CA8	1.33e-04	200	109	5	40286010bd17cf9e34ecd5440953b072ebfae208
ToppCell	Tracheal-10x5prime-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL4A2 ADAMTS12 MFGE8 SEMA6D ADGRL3	1.33e-04	200	109	5	fc2fc3bfcf1ad9bfb9fe07bbed8068126930bee6
ToppCell	(09)_Ionocytes-(3)_72hpi\|(09)_Ionocytes / shred by cell type and Timepoint	DIS3L CAMTA1 VWA2 ADGRL3	1.54e-04	110	109	4	fce7d5a0617fc664b657f5bb9abb290e7cc234cb
Disease	Malignant lymphoma - lymphocytic, intermediate differentiation	CCND1 ATM	3.40e-05	3	100	2	C0555202
Disease	Coxsackievirus Infections	SLC22A4 SLC22A5	1.69e-04	6	100	2	C0010246
Disease	Myocarditis	SLC22A4 SLC22A5	1.69e-04	6	100	2	C0027059
Disease	Carditis	SLC22A4 SLC22A5	1.69e-04	6	100	2	C0869523
Disease	acetylcarnitine measurement	SLC22A4 SLC22A5	3.14e-04	8	100	2	EFO_0021038
Disease	butyrylcarnitine measurement	SLC22A4 SLC22A5	3.14e-04	8	100	2	EFO_0020010
Disease	factor VIII measurement	STAB2 F12 ABCC12	3.41e-04	40	100	3	EFO_0004630
Disease	mental or behavioural disorder	COL4A2 GPR20 KRTAP4-7 SEMA6D KRTAP4-8	3.67e-04	179	100	5	EFO_0000677
Disease	nervonoylcarnitine (C24:1) measurement	SLC22A4 SLC22A5	4.03e-04	9	100	2	EFO_0800549
Disease	Small Lymphocytic Lymphoma	CCND1 ATM	5.03e-04	10	100	2	C0855095
Disease	B-CELL MALIGNANCY, LOW-GRADE	CCND1 ATM	5.03e-04	10	100	2	C1868683
Disease	Malignant mesothelioma	AGO2 SETDB1 SLC22A5 CCL7	5.26e-04	109	100	4	C0345967
Disease	lignoceroylcarnitine (C24) measurement	SLC22A4 SLC22A5	6.13e-04	11	100	2	EFO_0800541
Disease	tryptophan betaine measurement	SLC22A4 SLC22A5	7.34e-04	12	100	2	EFO_0021017
Disease	hexanoylcarnitine measurement	SLC22A4 SLC22A5	7.34e-04	12	100	2	EFO_0021040
Disease	colorectal cancer (is_implicated_in)	CCND1 PTPN13 BUB1B ATM	7.79e-04	121	100	4	DOID:9256 (is_implicated_in)
Disease	Intellectual Disability	IQSEC3 TMEM135 CAPN10 MED12L ZBTB11 TBCD CA8	8.34e-04	447	100	7	C3714756
Disease	homostachydrine measurement	SLC22A4 SLC22A5	8.66e-04	13	100	2	EFO_0021164
Disease	dihomo-linolenoylcarnitine (C20:3n3 or 6) measurement	SLC22A4 SLC22A5	8.66e-04	13	100	2	EFO_0800547
Disease	cerotoylcarnitine (C26) measurement	SLC22A4 SLC22A5	8.66e-04	13	100	2	EFO_0800542
Disease	head and neck squamous cell carcinoma (is_implicated_in)	CCND1 PTPN13	1.16e-03	15	100	2	DOID:5520 (is_implicated_in)
Disease	Mental Retardation, Psychosocial	TMEM135 CAPN10 TBCD CA8	1.30e-03	139	100	4	C0025363
Disease	Profound Mental Retardation	TMEM135 CAPN10 TBCD CA8	1.30e-03	139	100	4	C0020796
Disease	Mental deficiency	TMEM135 CAPN10 TBCD CA8	1.30e-03	139	100	4	C0917816
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	CCND1 ATM	1.32e-03	16	100	2	C0334634
Disease	oleoylcarnitine measurement	SLC22A4 SLC22A5	1.87e-03	19	100	2	EFO_0021043
Disease	maximal midexpiratory flow rate	GALNT14 MED12L	2.08e-03	20	100	2	EFO_0004313
Disease	mean platelet volume	GPR20 DIS3L ZMYND8 ATG14 SLC22A4 SLC22A5 KCNS1 CAMTA1 UBASH3B TBCD	2.43e-03	1020	100	10	EFO_0004584
Disease	stearoylcarnitine measurement	SLC22A4 SLC22A5	2.99e-03	24	100	2	EFO_0021045
Disease	lung squamous cell carcinoma (is_implicated_in)	PTPN13 ATM	2.99e-03	24	100	2	DOID:3907 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
CIVLCRRSRDPAYEL	TSPAN3	231	O60637
RTLYRSLCSCVFPLH	nan	31	Q6ZS49
RCLILRNRIHDPYDC	BUB1B	886	O60566
CYVHSSIIPTFHRRC	CAMTA1	151	Q9Y6Y1
LRCYCPAHDTGLVTL	CAMTA1	921	Q9Y6Y1
LYVAVERCPLCNTTR	ATG14	36	Q6ZNE5
LREPRYTLLVAACLC	ALG3	36	Q92685
AYLLHTTCLPLRVDC	CARMIL2	51	Q6F5E8
DSYIRRAIVHCLCPC	GPR15	306	P49685
LTCICVDRYLAIVRP	GPR20	141	Q99678
RRELSCESYPIELRC	ADGRL3	31	Q9HAR2
YISRCSVCEAPAIAI	COL4A2	1586	P08572
LSCVPHRYAQEVSRL	CAPN10	601	Q9HC96
LCCEVETIRRAYPDA	CCND1	6	P24385
KRYRLCNVHPCRSEA	ADAMTS12	586	P58397
LCHTYVRCTRSVSIP	AGO2	786	Q9UKV8
DRYIAICRPLHCSTV	OR4N4C	121	A0A096LPK9
PDSQSLRCDLIRYIC	INTS3	341	Q68E01
LRCDLIRYICGVVHP	INTS3	346	Q68E01
LHLYCDTCSVPICRE	TRIM71	286	Q2Q1W2
VCIVAVLRRYHSCLI	MED12L	881	Q86YW9
RCHRPKYQSALVCAL	MAS1	141	P04201
RLYPTSCHTACTLRF	MFGE8	206	Q08431
HRAVLACCSPYLFEI	IVNS1ABP	46	Q9Y6Y0
SLPHRRLVCCCQLYE	IQSEC2	966	Q5JU85
LVEVCVRDCSPHYRA	PLXNA1	936	Q9UIW2
DRYIAICRPLHCSTV	OR4N4	121	Q8N0Y3
CEESGRRVLVYSCRH	TPO	756	P07202
SYPSVCALRLRARHT	IGFBPL1	121	Q8WX77
DLRHPKRILFCTDYC	PRAMEF15	446	P0DUQ1
CHRLILSACSPYFRE	KLHL41	46	O60662
LRPVCGRVSCHTTCY	KRTAP4-11	161	Q9BYQ6
CCRARYLERRLTQPH	KCNS1	151	Q96KK3
CHRLVLAACSPYFRA	KLHL40	46	Q2TBA0
HCRRPRYLSSVMCVL	MRGPRX3	131	Q96LB0
YPFCRAQEIRHLLCE	OR2AG1	166	Q9H205
YSCRRPRHLTTCVCA	MRGPRE	131	Q86SM8
FPCRILLCENYRSHE	HELZ	856	P42694
PHRRLVCCSRLFEVT	IQSEC3	866	Q9UPP2
HRCSRIVRVEYRCPE	INSM2	281	Q96T92
TRHLRCTLLVYCTDL	GALNT14	96	Q96FL9
ACPLVCPRYHVASVT	MRGPRG	151	Q86SM5
RHPCLLRFLSCTVEA	SCYL3	61	Q8IZE3
CVSPVSNHVYERRLI	PRPF19	16	Q9UMS4
HRYLLCELVSDDPRC	POP5	6	Q969H6
TDRIRTCAILCHIYH	EIF3C	561	Q99613
RTDRIRTCAILCHIY	EIF3CL	561	B5ME19
RTPYVLRCLTEVALC	ATM	451	Q13315
IRIAYCIRPGTHCCL	DEFB110	51	Q30KQ9
CKRRTILTAIHCFPY	DOCK9	1916	Q9BZ29
CTERRRQTIVPVCSY	GFRA1	221	P56159
CPELRRLEVSGCYNI	FBXL7	211	Q9UJT9
ACACIYLAARTLEIP	CCNL2	241	Q96S94
IVREHYLRPCVPCHS	DIS3L	21	Q8TF46
RISYCARPTTHCCVT	DEFB112	71	Q30KQ8
LDVRLSPNYVVCRDC	CA8	66	P35219
EHSSESRCCRYPLTV	GDF11	306	O95390
SVPVYIRTCHRPSCT	LYPD5	176	Q6UWN5
LVHCREGYSRSPTLV	DUSP3	121	P51452
LRPVCGRVSCHTTCY	KRTAP4-6	171	Q9BYQ5
LRPVCGRVSCHTTCY	KRTAP4-7	176	Q9BYR0
LRPVCGRVSCHTTCY	KRTAP4-8	151	Q9BYQ9
VRPVCGRVSCHTTCY	KRTAP4-9	176	Q9BYQ8
SILRRPACVTSYSCR	KRTAP16-1	431	A8MUX0
LYRVSLACVCVRPRV	IL25	161	Q9H293
TFPCHRAVLAACSRY	ENC1	56	O14682
YRRTTSSHCPREAVI	CCL7	51	P80098
PCCLRALRETARYVV	FKRP	316	Q9H9S5
CPRVYHAKCLRLTSE	ZMYND8	106	Q9ULU4
YQDLETHRLPCTSRC	SCNN1D	601	P51172
EVPHSCSRYRLATIA	SLC22A4	76	Q9H015
EVPHSCRRYRLATIA	SLC22A5	76	O76082
CLRVLSCPRALRLHY	SALL2	636	Q9Y467
RVCPYHIRRCMTISI	GML	46	Q99445
SCHLPRDVLTRACAY	HMCES	6	Q96FZ2
LRSCRAHSVVPISCF	LRRC74B	61	Q6ZQY2
YRRCHPEAVTVRTST	PTPN13	321	Q12923
FCRTRIIPHTYCEHI	OR52H1	176	Q8NGJ2
YLPLLDRACASSVCR	FBXL21P	56	Q9UKT6
CEPCQTLAVRSYRLH	F12	436	P00748
CCSHARIPRTPYLVL	SYNE4	381	Q8N205
ECPICRQYVIRAVHV	RFFL	346	Q8WZ73
AEYCPVLRSLRVRHC	FBXL15	241	Q9H469
REYISTCVPECTHPL	ABCC12	1091	Q96J65
CLDSAYDPRICRQVI	OCRL	811	Q01968
CSYVLTIRTPRLCPH	OS9	216	Q13438
YEPVLCSRTTCRAVL	SEC23A	56	Q15436
CASCIAYPHEVIRTR	SLC25A33	246	Q9BSK2
HVCSYTCLSRVRPMR	SETDB1	576	Q15047
ICPYSVCSRHGLAIA	CNNM1	341	Q9NRU3
DLRHPKRILFCTDYC	PRAMEF4	446	O60810
PRLLYSCRLCTFVSH	ZNF513	146	Q8N8E2
IRKVYACSHCPDSRR	ZNF532	1081	Q9HCE3
CPVCSEAYIDARTLR	ZBTB11	916	O95625
RIHTRERSYVCIECG	ZNF549	296	Q6P9A3
DLRHPKRILFCTDYC	PRAMEF9	446	P0DUQ2
YGRRSVHIEVLCTLC	ZNF592	606	Q92610
TLHEAYCLRFLVLCP	XAF1	21	Q6GPH4
RHIPDTRVHCCVYFV	SEPTIN12	151	Q8IYM1
RVFLTHPATCYRTTC	VWA2	281	Q5GFL6
YLIQCCLRIPSAFRH	TMEM135	266	Q86UB9
IVYLPLSRCARHGAC	SEMA6C	511	Q9H3T2
EVRTYSLSLPGCRHI	STAB2	76	Q8WWQ8
CPCLSIYLIHERVHT	ZNF844	206	Q08AG5
RLVHTGERPYRCLQC	ZNF835	381	Q9Y2P0
LHVSRRVGYRCPSCS	ZNF687	756	Q8N1G0
REDCLPYAATVLRCL	TBCD	266	Q9BTW9
TIIDHVYCSPSLRCV	UBASH3B	461	Q8TF42
YCLVLQPLRARHCRE	ZDHHC12	101	Q96GR4
CPTCRYVISLNHRGL	MID2	76	Q9UJV3
CIIRIPLSRCERYGS	SEMA6D	506	Q8NFY4
VICDSYVRPCTLVRI	PHF5A	31	Q7RTV0
RHPKCYLERLSLESC	NLRP14	811	Q86W24
VATLMRCTPHYIRCI	MYO1F	571	O00160
RCTPHYIRCIKPNET	MYO1F	576	O00160