Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessmulticellular organismal reproductive process

SOX3 SPATA31D4 SPATA31D3 FNDC3A KMT2D ARRB2 ATN1 PTPRN ACR POC1B

4.34e-0511943810GO:0048609
GeneOntologyBiologicalProcessdevelopmental process involved in reproduction

SOX3 SPATA31D4 SPATA31D3 FNDC3A KMT2D ARRB2 ATN1 PTPRN GLI2 POC1B

5.77e-0512353810GO:0003006
DomainDUF4599

SPATA31D4 SPATA31D3

2.63e-0412382PF15371
DomainDUF4599

SPATA31D4 SPATA31D3

2.63e-0412382IPR027970
DomainGrowth_fac_rcpt_

ERBB3 TIE1 NOTCH4

3.89e-03156383IPR009030
Domainfn3

ROBO4 FNDC3A TIE1

4.33e-03162383PF00041
DomainHMG_box

SOX3 KMT2D

5.20e-0353382PF00505
DomainHMG

SOX3 KMT2D

5.40e-0354382SM00398
Domain-

SOX3 KMT2D

5.59e-03553821.10.30.10
DomainFN3

ROBO4 FNDC3A TIE1

6.25e-03185383SM00060
DomainFN3

ROBO4 FNDC3A TIE1

7.64e-03199383PS50853
DomainHMG_box_dom

SOX3 KMT2D

7.73e-0365382IPR009071
DomainFN3_dom

ROBO4 FNDC3A TIE1

8.74e-03209383IPR003961
DomainTyrKc

ERBB3 TIE1

1.38e-0288382SM00219
DomainTyr_kinase_cat_dom

ERBB3 TIE1

1.38e-0288382IPR020635
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

SOX3 KMT2D TLE2

6.84e-0542273M27272
Pubmed

A20-Binding Inhibitor of Nuclear Factor-κB Targets β-Arrestin2 to Attenuate Opioid Tolerance.

TNIP1 ARRB2

1.36e-06241234031190
Pubmed

The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function.

BCL11A ATN1

4.06e-06341222675500
Pubmed

A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions.

ERBB3 ARRB2

2.84e-05741217148612
Pubmed

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium.

TIE1 NOTCH4

2.84e-05741211344305
Pubmed

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.

ROBO4 TIE1 NOTCH4

4.72e-055941321421844
Pubmed

Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.

ROBO4 NOTCH4

6.07e-051041217496152
Pubmed

CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 gene variants and risk of childhood medulloblastoma.

KMT2D GLI2

6.07e-051041226290144
Pubmed

Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

TLE2 NOTCH4

7.41e-051141215499562
Pubmed

Meta-analysis identifies six new susceptibility loci for atrial fibrillation.

HCN4 SYNPO2L

8.88e-051241222544366
Pubmed

Developmental guidance of the retroflex tract at its bending point involves Robo1-Slit2-mediated floor plate repulsion.

ROBO4 GLI2

1.05e-041341225366972
Pubmed

Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium.

ROBO4 HCN4

1.41e-041541223255421
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

SPATA31D4 SPATA31D3 GPR63 NOTCH4

1.64e-0423341437704626
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

FNDC3A KMT2D ATN1 RBM12B FBRS

1.94e-0445741532344865
Pubmed

A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis.

SOX3 ERBB3

2.29e-041941234686326
Pubmed

The chromosomal location of the mouse mammary tumor gene Int6 and related pseudogenes in the mouse genome.

FNDC3A NOTCH4

2.29e-04194127558022
Pubmed

Klf2 is an essential regulator of vascular hemodynamic forces in vivo.

TIE1 NOTCH4

3.09e-042241217141159
Pubmed

Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation.

HCN4 GLI2

3.68e-042441234062094
Pubmed

Holoprosencephaly Overview

KMT2D GLI2

4.00e-042541220301702
Pubmed

Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment.

CSTF3 ACR

4.00e-042541215782160
Pubmed

Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.

ROBO4 NOTCH4

4.67e-042741235894043
Pubmed

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

TLE2 POC1B

5.03e-042841217041588
Pubmed

Extra-embryonic vasculature development is regulated by the transcription factor HAND1.

TIE1 NOTCH4

5.03e-042841215073150
Pubmed

Dosage-dependent requirement for mouse Vezf1 in vascular system development.

TIE1 NOTCH4

5.39e-042941215882861
Pubmed

Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy.

ERBB3 KMT2D ATN1

5.71e-0413741330862715
Pubmed

Interaction network of human early embryonic transcription factors.

KMT2D BCL11A ATN1 FBRS

7.69e-0435141438297188
Pubmed

GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.

GLI2 IER2

8.80e-043741222465667
Pubmed

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.

CSTF3 OGFOD1 RBM12B

8.80e-0415941330581152
Pubmed

An AUTS2-Polycomb complex activates gene expression in the CNS.

ATN1 FBRS

9.28e-043841225519132
Pubmed

Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.

BCL11A POC1B FBRS

9.79e-0416541316107646
Pubmed

Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.

BCL11A NYAP2

1.08e-034141220889853
InteractionPAX9 interactions

KMT2D BCL11A ATN1 TLE2 FBRS

3.82e-06130375int:PAX9
InteractionUTY interactions

HRG KMT2D TLE2

9.84e-0623373int:UTY
InteractionGSC interactions

KMT2D BCL11A ATN1 FBRS

1.92e-0587374int:GSC
Cytoband9q21.32

SPATA31D4 SPATA31D3

1.32e-04194129q21.32
GeneFamilyFibronectin type III domain containing

ROBO4 FNDC3A TIE1

9.26e-04160223555
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231|Adult / Lineage, Cell type, age group and donor

ROBO4 MMP11 ACR NOTCH4

1.67e-051674145af9127bae05768a5164d5708a4ad37edca99324
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ROBO4 NYAP2 TIE1 ACR

1.71e-0516841455c9de7b3a1d6cf7b02b020ff92ab4ede8d195cc
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HRG TIE1 ACR NOTCH4

1.79e-0517041455fe16d98ea284d05fb899888e4569c685644c7b
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NYAP2 TIE1 HCN4 NOTCH4

1.87e-05172414c84cab89c97d647b8a256fd08e33d9102810febd
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HRG TIE1 ACR NOTCH4

2.05e-0517641477516048aefbe1f48e825052756df0c310c1c486
ToppCelldroplet-Bladder-BLADDER-1m-Endothelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 TIE1 RBM12B NOTCH4

2.14e-051784146bef4ef48f649c6e38ae732bc08e6d7814db588b
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Pulmonary_neuroendocrine|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SOX3 HCN4 PTPRN SYNPO2L

2.24e-0518041457689ccbbd44c0e78e061edd87d3102c5f2dcc9a
ToppCell3'_v3-Lung-Myeloid_Dendritic-pDC|Lung / Manually curated celltypes from each tissue

SPATA31D3 BCL11A MMP11 NOTCH4

2.28e-051814143d7f089fb434fbc989f1fa159e22133ae00b2487
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ROBO4 TIE1 TLE2 NOTCH4

2.33e-05182414997d37ca2af661c92a56add888762724dfccc890
ToppCell5'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TFEB ROBO4 TIE1 NOTCH4

2.44e-0518441497e97de52daaff8840f4ee76a94ba5e3f79de7ce
ToppCelldroplet-Mammary_Gland-nan-21m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 TIE1 ACR NOTCH4

2.49e-0518541462cfcb0e2a9e6718e6b200dfbb1a81eaead229b5
ToppCelldroplet-Kidney-nan-3m-Endothelial-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 MMP11 TIE1 ACR

2.54e-05186414d72cdbb6d79ab33a5823c42e93c2ba566244f64c
ToppCellEndothelial-A-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

ROBO4 TIE1 ACR NOTCH4

2.54e-05186414796cbae2a417502aaf0891fc9c382bbfd88967fe
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ROBO4 TIE1 ACR NOTCH4

2.65e-05188414a11b12f1857953bcdbfb5f25e127f2350c39567d
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ROBO4 TIE1 ACR NOTCH4

2.71e-051894142e43428f1ef9683c6f8c9897d46aa7d34bf9047f
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-endo_bronchial_(8)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ROBO4 TIE1 ACR NOTCH4

2.71e-051894144bc3826e0515b3cf2e2ef72a7b2cf9c32ade1812
ToppCellEndothelial-A-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

ROBO4 TIE1 ACR NOTCH4

2.76e-051904146e83fa0eb8cabe0ffb35375f16e6bf3755ec4977
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ROBO4 TIE1 ACR NOTCH4

2.76e-051904142655df8c0883dd811fa7617301f9c4b0a4dd55ec
ToppCell10x5'-GI_large-bowel-Lymphocytic_B-Memory_B_cells|GI_large-bowel / Manually curated celltypes from each tissue

LARGE2 TFEB BCL11A MMP11

2.88e-0519241431f7245bce79969674a775ecf175e7c6af68b503
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ROBO4 TIE1 ACR NOTCH4

3.00e-0519441468004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCellEndothelial-A-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

ROBO4 TIE1 ACR NOTCH4

3.00e-05194414abea887dd472c1a0d572e690bc8914c1b94712ad
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Endothelial-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

ROBO4 TIE1 ACR NOTCH4

3.18e-05197414f969685dee212f33a6f09e54c0cd1fd24ffef546
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ROBO4 TIE1 ACR NOTCH4

3.18e-0519741496d63a8d00583e2aa0a38412e2ae27e23f399493
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ROBO4 TIE1 ACR NOTCH4

3.18e-051974141a137af40697137bb9d2b5caf2b1ffda55f04461
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ROBO4 TIE1 ACR NOTCH4

3.24e-05198414f88198e11e835ad53d339c312f8f7b7b0b5c02d3
ToppCellKidney-Endothelial|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.

ROBO4 TIE1 ACR NOTCH4

3.31e-05199414b543f0686522df43737e9ffa5c9733e42b8a9f4d
ToppCelldistal-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ROBO4 TNIP1 NOTCH4 IER2

3.37e-052004147a355c3883fd409b2e0868164bb6e7ce4b745776
ToppCellLPS-IL1RA+antiTNF-Unknown-Endothelial|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NYAP2 CAND2 FBRS

2.43e-0413241346c80eab16a70da9f363a9fbdf50bccab0b287d7
ToppCellLPS-IL1RA+antiTNF-Unknown|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NYAP2 CAND2 FBRS

2.43e-04132413a022c3c41654166cb106f27dc54fa88e8c40f898
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ROBO4 TIE1 NOTCH4

2.48e-04133413bc29a2faa151b0e48c1c7e3f016cccc49f9a15eb
ToppCellTCGA-Peripheral_Nervous_System-Primary_Tumor-Paraganglioma-Paraganglioma-3|TCGA-Peripheral_Nervous_System / Sample_Type by Project: Shred V9

FNDC3A KMT2D RBM12B

2.59e-04135413ac20133d4a36f48338b45bffb13e842cb66f83ad
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

LARGE2 BCL11A MMP11

3.01e-0414241366135fee18448cc09a78bc6ede05afd63c72ae21
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-7|TCGA-Endometrium / Sample_Type by Project: Shred V9

ROBO4 NOTCH4 SYNPO2L

3.19e-04145413ffbdadea0185e5d3b85f2868d5ec82b50cf2e2a1
ToppCellsevere_COVID-19-MAIT|World / disease group, cell group and cell class (v2)

ERBB3 MMP11 SYNPO2L

3.81e-0415441365ec7f7ef05c589903c4c9fe3849478c325fdc61
ToppCellLPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NYAP2 CAND2 FBRS

3.81e-0415441316fdafb5c64d2db321554f87129a962d113f1668
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ROBO4 TIE1 NOTCH4

3.81e-04154413b0735365de153d4586ca17896431d7bd9c7d8eac
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK|Thalamus / BrainAtlas - Mouse McCarroll V32

ROBO4 TIE1 NOTCH4

3.88e-04155413fe6c4aba0e98cda84bf178aeac2e9fa834477f22
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 TIE1 NOTCH4

3.96e-04156413f894fac4e44a23718b20ad80c9677bf4f2118002
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Junb_(Mural,_IEG+)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PNRC1 CAND2 SYNPO2L

3.96e-041564135df19a235843829f5a1a90ca21b0964ef8b4e115
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Junb_(Mural,_IEG+)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PNRC1 CAND2 SYNPO2L

3.96e-04156413029ba0832ee9c4a2c85620e4df2260e02d86b45c
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ROBO4 TIE1 ACR

4.03e-041574132c946c6ab284fac3c25db688ed0aabe5a3f9ffa5
ToppCellControl-Endothelial_cells-Inflamed_endothelial_cells|Control / group, cell type (main and fine annotations)

ROBO4 TIE1 NOTCH4

4.26e-04160413958256e3d3836160763b82bb48f794087918d935
ToppCellsevere-Myeloid-pDC|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

BCL11A MMP11 NOTCH4

4.34e-041614139e8e8ac11f7fb8c8697357c21034b613f191db2b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 TIE1 NOTCH4

4.42e-04162413c399b9e4854916a59f5cae2d8dbf19660f8759be
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 TIE1 NOTCH4

4.42e-04162413a291248b693c771845174393934a782f1d8bd7ce
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 TIE1 NOTCH4

4.50e-041634131feb4ef7b8abcfca9a72c8d13c40548de79e7db2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 TIE1 NOTCH4

4.50e-0416341373c03e29a6d7a6863c5e9aa5e8b963ef691f1ddb
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARRB2 TIE1 NOTCH4

4.50e-04163413bb09e6ca3406eee0593d9a312db7e05934309dd2
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|Fibroblasts / Location, Cell class and cell subclass

MMP11 PTPRN APCDD1L

4.58e-041644139b4a6007abae992db871d9f6f731d5af724de30d
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LARGE2 ERBB3 NYAP2

4.58e-04164413d6f71d804bb65301c02ea4e6673e20688b5fcd5b
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FAM20C CAND2 TIE1

4.66e-0416541362457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCellsevere-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

BCL11A MMP11 NOTCH4

4.74e-04166413ae38850fde549b8dd6fb12f0ef80b428ade50485
ToppCellInfluenza_Severe-pDC|Influenza_Severe / Disease group and Cell class

BCL11A MMP11 NOTCH4

4.74e-04166413b43a5cd4d28118cf6e56a435deb8ea9435608a90
ToppCellsevere-Myeloid-mDC|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ROBO4 BCL11A ZNF385A

4.83e-0416741350b1cea9048bd8df9aff3fb9a548443f950d1090
ToppCell10x5'-Lung-Myeloid_Dendritic-pDC|Lung / Manually curated celltypes from each tissue

GPR63 BCL11A MMP11

4.91e-0416841390f713dae3fcbd6ca801a019e3861c263ff3366b
ToppCellMild/Remission-B_naive-4|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

LARGE2 PNRC1 BCL11A

5.00e-04169413c3a6179a64589a370108fea809b157839347759c
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|356C / Donor, Lineage, Cell class and subclass (all cells)

TIE1 NOTCH4 APCDD1L

5.00e-04169413337be3bf485b54afad86e256cb0c4c1d0c2a9a2a
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|356C / Donor, Lineage, Cell class and subclass (all cells)

TIE1 NOTCH4 APCDD1L

5.00e-04169413605cc2638271803cf1d972ab3fa8f13f89666376
ToppCelldroplet-Kidney-nan-21m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARRB2 ZNF385A MMP11

5.08e-04170413510625bd725d3590cffcd7acd1d42219f6eb1139
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D122|Adult / Lineage, Cell type, age group and donor

ROBO4 TIE1 NOTCH4

5.17e-04171413bd20e85d36fa9d7ddc8afef6a1dea75efc9ee1dc
ToppCelldroplet-Lung-nan-18m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OGFOD1 FAM20C ARRB2

5.17e-041714137ca404539344e14dcd90c746c9122f713a7db78b
ToppCelldroplet-Lung-nan-18m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OGFOD1 FAM20C ARRB2

5.17e-04171413ab113c8e773b0af47a87aed50e96be3ba71c3c82
ToppCell5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ROBO4 TIE1 NOTCH4

5.17e-04171413b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TIE1 ACR NOTCH4

5.17e-041714131597459c971d6befa991d59dc66b41b6a522f797
ToppCellCOVID-pDC|COVID / Condition, Cell_class and T cell subcluster

BCL11A MMP11 NOTCH4

5.26e-041724133ecbb000495dde32f6153ef6bdea9c8802ff3985
ToppCellControl-Endothelial_cells-Systemic_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

TIE1 ACR NOTCH4

5.26e-04172413c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCellEndothelial-A-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

ROBO4 TIE1 NOTCH4

5.26e-04172413a3201773a25832e92dd113fad165f1ecd37f5e91
ToppCellCOVID-pDC-|COVID / Condition, Cell_class and T cell subcluster

BCL11A MMP11 NOTCH4

5.26e-04172413a7827faa1afab51fdaf0cb1a2babcd2e00d411e5
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)|368C / Donor, Lineage, Cell class and subclass (all cells)

TIE1 NOTCH4 APCDD1L

5.35e-0417341322200fe74e33e2beae0eed289ca8476bbc0b1b2d
ToppCelldroplet-Fat-SCAT-30m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIE1 RBM12B NOTCH4

5.35e-04173413eb58b0189e71e38d4f4f1cf544a82cde8d1c86bc
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)-|368C / Donor, Lineage, Cell class and subclass (all cells)

TIE1 NOTCH4 APCDD1L

5.35e-04173413ec88e871b49331fca59bc610a8ae58e2d5e76bc1
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Endothelial-endothelial_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HRG TIE1 NOTCH4

5.35e-041734132a5ea28c65dd4ee03ba3d0bfe0c819b1d583f8da
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Endothelial|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HRG TIE1 NOTCH4

5.35e-041734136a7e4fa2d9d00f50decc89b535d8a68ec96de58a
ToppCelldroplet-Fat-Scat-21m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 TIE1 SYNPO2L

5.35e-04173413f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
ToppCelldroplet-Heart-4Chambers-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 TIE1 NOTCH4

5.35e-041734139a04271c51fae34f547db3206f9ff5857686e45c
ToppCelldroplet-Mammary_Gland-nan-3m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 TIE1 NOTCH4

5.35e-04173413fbc8ed566ea36c39c258dd6b3823c82f5d6eb17f
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l27|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ROBO4 TIE1 ACR

5.35e-04173413ad9777e4ae70b11676ec735eb6db91776ca0cb19
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D|PND01-03-samps / Age Group, Lineage, Cell class and subclass

ROBO4 TIE1 NOTCH4

5.44e-04174413b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCelldroplet-Lung-18m-Hematologic-myeloid-interstitial_macrophage|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

OGFOD1 FAM20C ARRB2

5.44e-04174413ca0c2f42544092848541863c4a47b334e6828b8a
ToppCelldroplet-Lung-18m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

OGFOD1 FAM20C ARRB2

5.44e-0417441333e5903adb746f693433bdca11a75c508bbf50c0
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ROBO4 TIE1 NOTCH4

5.44e-04174413b1bcd5f4505d2ccef4183fcfbf1de81964b3f9e0
ToppCell3'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TFEB PNRC1 TNIP1

5.53e-04175413cd42020fe57afeaadfbd3ef6d7375e66d71e9669
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

LARGE2 NYAP2 PTPRN

5.53e-041754139941c35601134d88d1b3249c81f8b43a8fc61610
ToppCell368C-Endothelial_cells-Endothelial-D|368C / Donor, Lineage, Cell class and subclass (all cells)

ROBO4 TIE1 NOTCH4

5.53e-04175413c4088b5f9fa145869cf5dd8bee7680b1c8fada42
ToppCell368C-Endothelial_cells-Endothelial-D-|368C / Donor, Lineage, Cell class and subclass (all cells)

ROBO4 TIE1 NOTCH4

5.53e-04175413ca0d3e3a0a271cccdd3881b055fecb626712478d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 TIE1 NOTCH4

5.53e-0417541390302e8a44858ef3b2a165b88284d4788d591a99
ToppCelldroplet-Kidney-nan-18m-Endothelial-kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 TIE1 NOTCH4

5.62e-041764135386386619cf173939d3c117b20e6f27ab397993
ToppCellfacs-Heart-RV-18m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 TIE1 NOTCH4

5.62e-04176413fb3d03f64592e1df1d9785d9f2e70938d7ff9ce8
ToppCellfacs-Heart-RV-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 TIE1 NOTCH4

5.62e-041764133270a36fc91a5583646ffeb70bfcbc5af7292aac
ToppCelldroplet-Kidney-nan-18m-Endothelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 TIE1 NOTCH4

5.62e-04176413820edade963768e4bfd86b554da4cd7100567ac8
ToppCellfacs-Heart-RV-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROBO4 TIE1 NOTCH4

5.62e-0417641399410c121f55adbc7fcc013c8fa8905a45dba76b
ToppCellnormal_Lung-Endothelial_cells-EPCs|normal_Lung / Location, Cell class and cell subclass

ROBO4 TIE1 NOTCH4

5.62e-0417641371d1bd425772d89d8c550b909e0ec0e36ff22a7e
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ROBO4 TIE1 NOTCH4

5.62e-0417641396779273b94345250cf53ba671203345b43d9e00
ToppCellAdult-Endothelial-endothelial_cell_of_vein|Adult / Lineage, Cell type, age group and donor

ROBO4 ACR NOTCH4

5.62e-04176413043683c61c5d1a7f8a4666a612310246bd3d83a2
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ROBO4 MMP11 NOTCH4

5.72e-0417741316197068260fc062bf8b730a51a199887ea580b9
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ROBO4 TIE1 NOTCH4

5.72e-0417741312f8627124acbf436e75681ff1ce429ff5e3f256
ToppCellfacs-Lung-EPCAM-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR63 TIE1 ACR

5.72e-041774132433924dcb085ebbe2545d476ebd7ee68e6092fb
ToppCelltumor_Lung-Endothelial_cells-EPCs|tumor_Lung / Location, Cell class and cell subclass

TIE1 PTPRN NOTCH4

5.72e-04177413f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ROBO4 TIE1 NOTCH4

5.72e-04177413fdf2af00fc971f0cd3915e1416e4a256458d6ea8
ToppCellmyeloid-Dendritic_cell-Plasmacytoid_dendritic_cell|myeloid / Lineage, cell class and subclass

BCL11A MMP11 NOTCH4

5.81e-04178413f75591988bbbeba073b66329a3437cb9b02f7648
DiseaseMalignant neoplasm of skin

ERBB3 GLI2 NOTCH4

6.59e-0559393C0007114
DiseaseSkin Neoplasms

ERBB3 GLI2 NOTCH4

6.59e-0559393C0037286
Diseaseschizophrenia (is_implicated_in)

BCL11A ATN1 NOTCH4

1.52e-0478393DOID:5419 (is_implicated_in)
Diseasecolorectal adenocarcinoma (is_marker_for)

ERBB3 IER2

5.85e-0427392DOID:0050861 (is_marker_for)
DiseaseMammary Carcinoma, Human

HRG TNIP1 ERBB3 KMT2D NOTCH4

6.11e-04525395C4704874
DiseaseMammary Neoplasms, Human

HRG TNIP1 ERBB3 KMT2D NOTCH4

6.11e-04525395C1257931
DiseaseMammary Neoplasms

HRG TNIP1 ERBB3 KMT2D NOTCH4

6.22e-04527395C1458155
DiseaseBreast Carcinoma

HRG TNIP1 ERBB3 KMT2D NOTCH4

6.83e-04538395C0678222
DiseaseParoxysmal atrial fibrillation

CAND2 HCN4 SYNPO2L

1.15e-03156393C0235480
Diseasefamilial atrial fibrillation

CAND2 HCN4 SYNPO2L

1.15e-03156393C3468561
DiseasePersistent atrial fibrillation

CAND2 HCN4 SYNPO2L

1.15e-03156393C2585653
Diseaseattention deficit hyperactivity disorder

TFEB BCL11A NYAP2 POC1B

1.20e-03354394EFO_0003888
DiseaseAtrial Fibrillation

CAND2 HCN4 SYNPO2L

1.24e-03160393C0004238
DiseaseIGFBP-3 measurement

ERBB3 NOTCH4

2.33e-0354392EFO_0004626

Protein segments in the cluster

PeptideGeneStartEntry
PITHPLLHPAPGPIR

ZNF385A

361

Q96PM9
HSPPHPPRPSSLEEL

ERBB3

1206

P21860
PIRPPFSHPISAHLP

ACR

311

P10323
LHPFPFHPSLGPLER

ATN1

986

P54259
RSDVHHPPVLPPPLA

APCDD1L

261

Q8NCL9
HPKPHDHIPLPRPQS

ARRB2

346

P32121
RPPPEHFRRPPPEHF

RBM12B

741

Q8IXT5
PPPEHFRRPPPEHFR

RBM12B

766

Q8IXT5
HVTFLPHEPPPPRPH

LARGE2

416

Q8N3Y3
PPIPRSPHIPQDHEI

OGFOD1

251

Q8N543
SALSLPPLSLPHPHP

NTM-AS1

81

Q6ZSK4
EHLLLPPQPPHPSLS

PTPRN

186

Q16849
PLPEANFPSFPLPHH

HRG

471

P04196
PTPPLFSPPPRHHLD

BCL11A

261

Q9H165
FSPPPRHHLDPHRIE

BCL11A

266

Q9H165
PDPRALPPTLFLPHF

PNRC1

46

Q12796
LLRHHPFLPSDPEPP

PERCC1

16

A0A1W2PR82
PFQPRHLAPPGLHPV

CSTF3

591

Q12996
EPPETRVSHLHPEPP

FAM47B

286

Q8NA70
PQHLLPPFHAPLPID

GLI2

51

P10070
SPPHLLDIYPRTPHP

POC1B

321

Q8TC44
SHRPPLLVFPPAPVH

NYAP2

331

Q9P242
THHPRLPAAIFRPPP

HCN4

796

Q9Y3Q4
HLLFERPRPPPFLGP

FBRS

336

Q9HAH7
SQPPEPLRPLKHPSH

C5orf60

236

A6NFR6
FLPVPSSPHTHPLLP

LINC00322

86

Q6ZN03
PGALRPHDPAHRPLL

FAM20C

126

Q8IXL6
PHDPAHRPLLRDPGP

FAM20C

131

Q8IXL6
LHRSPHPPLPGFIPV

FNDC3A

111

Q9Y2H6
LPPPFQHPDLSPLLR

GPR63

31

Q9BZJ6
PAEAFHPHLPILLPP

CAND2

511

O75155
LPAALPSDPRLHPPR

IER2

61

Q9BTL4
PPPLLARALPPDAHH

MMP11

26

P24347
EALLLPHGPLRPGPH

SYNPO2L

216

Q9H987
ISLPFPPDSLAHRPP

SOX3

26

P41225
LPLPTQPPSPFHHLD

TFEB

381

P19484
PFPLLPPHHIERVEP

SPATA31D4

241

Q6ZUB0
LEPLLPGPLLAVHPH

NOTCH4

1421

Q99466
PLSMVPPDPHHLLPD

ROBO4

71

Q8WZ75
PPDPHHLLPDGTLLL

ROBO4

76

Q8WZ75
TRHLPPAPLFPHETP

ROBO4

711

Q8WZ75
HPPPLPNSRLFHLPE

TNIP1

581

Q15025
PFPLLPPHHIERVEP

SPATA31D3

241

P0C874
HVLLPPSGPPAPRHL

TIE1

636

P35590
STLPPRPIPHPFSHL

ZNF652

536

Q9Y2D9
HHAPPVPLTPRPAGL

TLE2

131

Q04725
PHLSPRPEEPHLSPR

KMT2D

741

O14686
RPEEPHLSPRPEEPH

KMT2D

746

O14686