Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glutathione hydrolase activity	GGTLC3 GGT1	3.48e-04	9	63	2	GO:0036374
GeneOntologyMolecularFunction	unmethylated CpG binding	KDM2A FBXL19	4.34e-04	10	63	2	GO:0045322
Domain	Tankyrase_bdg_C	KIAA1671 TNKS1BP1	1.05e-05	2	61	2	SM01319
Domain	Tankyrase-bd_C	KIAA1671 TNKS1BP1	1.05e-05	2	61	2	IPR032764
Domain	Tankyrase_bdg_C	KIAA1671 TNKS1BP1	1.05e-05	2	61	2	PF15327
Domain	PHD_4	KDM2A FBXL19	3.14e-05	3	61	2	PF16866
Domain	Znf_CXXC	KDM2A FBXL19	5.66e-04	11	61	2	IPR002857
Domain	ZF_CXXC	KDM2A FBXL19	5.66e-04	11	61	2	PS51058
Domain	zf-CXXC	KDM2A FBXL19	5.66e-04	11	61	2	PF02008
Domain	Leu-rich_rpt_Cys-con_subtyp	KDM2A FBXL19	1.73e-03	19	61	2	IPR006553
Domain	LRR_CC	KDM2A FBXL19	1.73e-03	19	61	2	SM00367
Domain	-	SAFB SAFB2	2.12e-03	21	61	2	1.10.720.30
Domain	SAP	SAFB SAFB2	2.32e-03	22	61	2	PF02037
Domain	SAP	SAFB SAFB2	2.54e-03	23	61	2	SM00513
Domain	SAP	SAFB SAFB2	3.00e-03	25	61	2	PS50800
Domain	SAP_dom	SAFB SAFB2	3.00e-03	25	61	2	IPR003034
Domain	RRM_1	SAFB EIF4H RBM15B SAFB2	4.75e-03	208	61	4	PF00076
Domain	EF-hand_8	RYR1 CAPN11	5.50e-03	34	61	2	PF13833
Domain	RRM	SAFB EIF4H RBM15B SAFB2	5.52e-03	217	61	4	SM00360
Domain	RRM_dom	SAFB EIF4H RBM15B SAFB2	6.45e-03	227	61	4	IPR000504
Domain	RRM	SAFB EIF4H RBM15B SAFB2	6.76e-03	230	61	4	PS50102
Domain	-	SAFB EIF4H RBM15B SAFB2	8.29e-03	244	61	4	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	SAFB EIF4H RBM15B SAFB2	1.00e-02	258	61	4	IPR012677
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	STRN3 SAFB MAP1S MYCBP2 RBM15B SAFB2 KLC2 GIGYF2 TNKS1BP1 ADD1	1.44e-06	774	64	10	15302935
Pubmed	No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p.	SAFB SAFB2	3.33e-06	2	64	2	19077293
Pubmed	Low SAFB levels are associated with worse outcome in breast cancer patients.	SAFB SAFB2	3.33e-06	2	64	2	19137425
Pubmed	Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?	SAFB SAFB2	3.33e-06	2	64	2	14587024
Pubmed	SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells.	SAFB SAFB2	3.33e-06	2	64	2	19901029
Pubmed	Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells.	SAFB SAFB2	3.33e-06	2	64	2	26273616
Pubmed	Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1.	SAFB SAFB2	3.33e-06	2	64	2	26092125
Pubmed	Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively inhibit the intranuclear mobility and function of ERα.	SAFB SAFB2	3.33e-06	2	64	2	22566185
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	MYCBP2 GIGYF2 TNKS1BP1 ACSS2 ADCY5 ADD1 RUSC2	3.53e-06	347	64	7	17114649
Pubmed	The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2.	SAFB SAFB2	9.99e-06	3	64	2	19674106
Pubmed	iCLIP identifies novel roles for SAFB1 in regulating RNA processing and neuronal function.	SAFB ASTN2	9.99e-06	3	64	2	26694817
Pubmed	SAFB1 interacts with and suppresses the transcriptional activity of p53.	SAFB SAFB2	2.00e-05	4	64	2	21130767
Pubmed	Scaffold attachment factor SAFB1 suppresses estrogen receptor alpha-mediated transcription in part via interaction with nuclear receptor corepressor.	SAFB SAFB2	2.00e-05	4	64	2	16195251
Pubmed	SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor.	SAFB SAFB2	2.00e-05	4	64	2	12660241
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	KIAA1671 CDR2L DNAAF2 FLG MYCBP2 SMDT1 GIGYF2 STYXL2 TNKS1BP1 NOPCHAP1 FBXL19	2.66e-05	1321	64	11	27173435
Pubmed	Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase.	GGTLC3 GGT1	3.32e-05	5	64	2	2904146
Pubmed	Expression of multiple gamma-glutamyltransferase genes in man.	GGTLC3 GGT1	3.32e-05	5	64	2	7906515
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	KIAA1671 STRN3 SAFB EIF4H SAFB2 GIGYF2 TNKS1BP1 NOPCHAP1 ADD1	5.13e-05	934	64	9	33916271
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	MYCBP2 SAFB2 GIGYF2	7.46e-05	44	64	3	26471122
Pubmed	RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery.	KLC2 RUSC2	9.27e-05	8	64	2	34432492
Pubmed	PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.	SAFB MAP1S EIF4H MYCBP2 TNKS1BP1	9.40e-05	247	64	5	32989298
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SAFB MAP1S CLK3 RBM15B SAFB2	1.01e-04	251	64	5	31076518
Pubmed	Intrinsically Disordered Protein TEX264 Mediates ER-phagy.	SAFB MAP1S TEX264 SAFB2	1.03e-04	131	64	4	31006538
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	KIAA1671 CNNM3 COL18A1 SAFB NBEAL2 DOK3 NOPCHAP1 FBXL19	1.41e-04	832	64	8	36724073
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	KDM2A FBXL19	1.49e-04	10	64	2	29276034
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIAA1671 CDR2L MYCBP2 CLK3 KLC2 GIGYF2 TNKS1BP1 RUSC2	1.78e-04	861	64	8	36931259
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PPP1R26 CDR2L MAP1S FAM83F MYCBP2 NBEAL2 TNKS1BP1 FBXL19 RYR1	1.83e-04	1105	64	9	35748872
Pubmed	The human gamma-glutamyltransferase gene family.	GGTLC3 GGT1	2.99e-04	14	64	2	18357469
Pubmed	Tagging genes with cassette-exchange sites.	SAFB EIF4H SAFB2 GIGYF2 FBXL19	3.85e-04	335	64	5	15741177
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KIAA1671 MYCBP2 GIGYF2 KDM2A TNKS1BP1 ADD1	5.20e-04	549	64	6	38280479
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	KIAA1671 EIF4H KLC2 GIGYF2 TNKS1BP1 ADD1	6.04e-04	565	64	6	25468996
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	KIAA1671 EIF4H TNKS1BP1 ADD1	6.07e-04	209	64	4	36779422
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	STRN3 MYCBP2 SAFB2 TNKS1BP1	6.40e-04	212	64	4	33853758
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	MYCBP2 GIGYF2 KDM2A TNKS1BP1	8.00e-04	225	64	4	12168954
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PPP1R26 GIGYF2 ASTN2	8.96e-04	102	64	3	9734811
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	ARMCX4 ADCY5	8.96e-04	24	64	2	32212159
Pubmed	Large-scale cDNA transfection screening for genes related to cancer development and progression.	TLCD3B NEU4 IER5	1.24e-03	114	64	3	15498874
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	MYCBP2 CLK3 KLC2 SHROOM2	1.27e-03	255	64	4	15324660
Pubmed	Genome-wide association study of smoking behaviours in patients with COPD.	BST1 ASTN2	1.31e-03	29	64	2	21685187
Pubmed	Defining the membrane proteome of NK cells.	CNNM3 EIF4H MYCBP2 CLK3 NBEAL2 ACBD5 KLC2 GIGYF2	1.32e-03	1168	64	8	19946888
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	KIAA1671 STRN3 MAP1S KLC2 GIGYF2	1.39e-03	446	64	5	24255178
GeneFamily	Zinc fingers CXXC-type	KDM2A FBXL19	2.51e-04	12	36	2	136
GeneFamily	CD molecules\|Gamma-glutamyltransferases	GGTLC3 GGT1	2.97e-04	13	36	2	564
GeneFamily	F-box and leucine rich repeat proteins	KDM2A FBXL19	7.90e-04	21	36	2	558
GeneFamily	RNA binding motif containing	SAFB EIF4H RBM15B SAFB2	8.21e-04	213	36	4	725
Coexpression	GSE17580_UNINFECTED_VS_S_MANSONI_INF_TEFF_UP	CNNM3 MYCBP2 TEX264 DOK3 RBM15B ACSS2 ADD1 GGT1	2.70e-08	200	63	8	M3675
Disease	aflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)	GGTLC3 GGT1	7.65e-05	7	57	2	DOID:5022 (biomarker_via_orthology)
Disease	alcohol dependence (biomarker_via_orthology)	GGTLC3 GGT1	1.02e-04	8	57	2	DOID:0050741 (biomarker_via_orthology)
Disease	body fat percentage, type 2 diabetes mellitus	KLF14 ADCY5	4.89e-04	17	57	2	EFO_0007800, MONDO_0005148
Disease	Uterine leiomyoma, breast carcinoma	FAM83F ASTN2	1.75e-03	32	57	2	EFO_0000305, HP_0000131
Disease	bipolar I disorder	CNNM3 LRRC3C ASTN2	2.59e-03	141	57	3	EFO_0009963
Disease	cups of coffee per day measurement	CLK3 ADD1	2.73e-03	40	57	2	EFO_0006782

Protein segments in the cluster

Peptide	Gene	Start	Entry
AAGGARARWRGEGTS	BST1	26	Q10588
SSWRDLRGGEEGQGE	CDR2L	396	Q86X02
DGERWGSDRGSRGSL	ACBD5	431	Q5T8D3
RGARSGEWGLAAAGA	CLK3	131	P49761
GSDWSRGEAAGVDRG	C1orf122	6	Q6ZSJ8
RKDGDVSAAWSGSGR	SMDT1	26	Q9H4I9
ESARDWSGGRSGRSG	FLG	1101	P20930
SAWQERGGDDCGRGS	ADCY5	101	O95622
GQEEAGAGGRARSWS	ACSS2	16	Q9NR19
EGSWRRGSSAGGCRN	CAPN11	396	Q9UMQ6
DRAGCDSWRAGGGAS	DNAJB8	66	Q8NHS0
GAGEEAGVESWTLAR	ARMCX4	1866	Q5H9R4
LRESDIGWSGARAGA	ASTN2	76	O75129
RADNGEEGASLGSGW	FBXL19	166	Q6PCT2
RSRSGERWGADGDRG	RBM15B	571	Q8NDT2
EEELCGSGWGGARRS	LRRC3C	206	A6NJW4
GSGWGGARRSTDVAL	LRRC3C	211	A6NJW4
GGWDSRDDFNSGFRD	EIF4H	146	Q15056
ERSEVAAGGGSWDDR	MAP1S	311	Q66K74
ADGEAAAGGEWASRR	KIAA1671	421	Q9BY89
SLTGGEESARAWGGS	GPR162	561	Q16538
AWGSSAGRESARGDS	DNAAF2	476	Q9NVR5
ESGEQVRAGARAWGG	COL18A1	361	P39060
SWEVRDGGLGAAGDR	DOK3	101	Q7L591
WGSARDLTEEAIGGA	NEU4	136	Q8WWR8
TGGREGAEWRAGGRE	INSM2	86	Q96T92
TAGGWAAASDSRKGG	GGTLC3	206	B5MD39
EWNGDGSGSLRRSGS	KLC2	531	Q9H0B6
EEGGAARLNGRGSWA	KDM2A	871	Q9Y2K7
EDGGWRLAGSRRDGE	GIGYF2	216	Q6Y7W6
SLWQGAERGGGERRE	CCER2	196	I3L3R5
DGGGWTVIQRRSDGS	FGL1	116	Q08830
DLRGSSGEGSWENSG	KLF14	91	Q8TD94
GRGGRDHGDWDEASR	CREG1	31	O75629
GGGHSRERADEPQWS	CHGB	126	P05060
RSAGGWSEAENGKEG	RYR1	1336	P21817
AAREAEGTAGGWGVF	IER5	151	Q5VY09
AEAAGGSGRARWARG	RUSC2	1251	Q8N2Y8
GAGEARSSGDGTEWD	STRN3	316	Q13033
RAGGRAEAASWGDRG	SH3D21	11	A4FU49
AEAASWGDRGNDKGG	SH3D21	16	A4FU49
RGVEGSDEAAWRERG	NBEAL2	1456	Q6ZNJ1
TAAGEAEDGTGRWRA	SHROOM2	651	Q13796
DEGEAWSLARDRGGN	MYCBP2	2651	O75592
GRDAVWRGGVGSERD	PPP1R26	1046	Q5T8A7
DGESAAGSGGGRWRL	SOWAHC	401	Q53LP3
SRWEDGSRDGVSLGA	SMIM1	11	B2RUZ4
TAGSDGRGGIWDRLL	NOPCHAP1	31	Q8N5I9
EGQEEGASGGESAWR	FAM83F	356	Q8NEG4
RREDDRSWQGTADGG	SAFB	826	Q15424
RWLNSGRGDEASEEG	ADD1	446	P35611
GGWGGAQEEEREREA	CLEC11A	31	Q9Y240
AGWVRGGAARDTPDA	CNNM3	46	Q8NE01
NERVRGLETGDWGGA	ZSWIM9	466	Q86XI8
RSVGASDGSSWEGVG	RBP3	1196	P10745
NADRGAAGGAGVESW	MKRN3	186	Q13064
GEGAVGGFRSSWCED	SPNS3	236	Q6ZMD2
GWRSASSGQGGEELE	STYXL2	371	Q5VZP5
GAGEGSTREWASRCG	TNKS1BP1	781	Q9C0C2
GASSRGWDDGDTRSE	TEX264	246	Q9Y6I9
DGAGRGCGRATWSVR	RPS6KL1	371	Q9Y6S9
RDSRDGWGGYGSDKR	SAFB2	816	Q14151
SGSSRQAGDEKEWRG	ZNF205	181	O95201
GGDDGAARAPGSTWA	TLCD3B	106	Q71RH2
AGGWAAASDSRKGGE	GGT1	551	P19440
GAGDTQEWERGREPA	LRRC73	266	Q5JTD7