Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionantigen binding

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.04e-04190314GO:0003823
GeneOntologyBiologicalProcessadaptive immune response

IGHV3-48 TRAV8-6 TRAV8-2 IGKV3D-7 TRAV5 C5 IGHV3-21 IGHV3-11 TRAV39 IGLV9-49 TRAV18 IGHV3-66

9.52e-098383612GO:0002250
GeneOntologyBiologicalProcessimmunoglobulin mediated immune response

IGHV3-48 C5 IGHV3-21 IGHV3-11 IGHV3-66

5.20e-05235365GO:0016064
GeneOntologyBiologicalProcessB cell mediated immunity

IGHV3-48 C5 IGHV3-21 IGHV3-11 IGHV3-66

6.21e-05244365GO:0019724
GeneOntologyBiologicalProcesscollagen-activated tyrosine kinase receptor signaling pathway

COL4A2 COL4A3

1.93e-0412362GO:0038063
GeneOntologyBiologicalProcesssignal peptide processing

SPPL3 PCSK5

2.66e-0414362GO:0006465
GeneOntologyCellularComponentimmunoglobulin complex

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11 IGLV9-49 IGHV3-66

6.02e-07166396GO:0019814
GeneOntologyCellularComponentT cell receptor complex

TRAV8-6 TRAV8-2 TRAV5 TRAV39 TRAV18

1.26e-05163395GO:0042101
GeneOntologyCellularComponentcollagen type IV trimer

COL4A2 COL4A3

5.06e-056392GO:0005587
GeneOntologyCellularComponentreceptor complex

TRAV8-6 TRAV8-2 TRAV5 TRAV39 TRAV18 PTPRQ GABRA3

8.77e-05581397GO:0043235
GeneOntologyCellularComponentbasement membrane collagen trimer

COL4A2 COL4A3

9.43e-058392GO:0098651
GeneOntologyCellularComponentnetwork-forming collagen trimer

COL4A2 COL4A3

9.43e-058392GO:0098642
GeneOntologyCellularComponentcollagen network

COL4A2 COL4A3

9.43e-058392GO:0098645
GeneOntologyCellularComponentplasma membrane signaling receptor complex

TRAV8-6 TRAV8-2 TRAV5 TRAV39 TRAV18

4.61e-04350395GO:0098802
GeneOntologyCellularComponentcomplex of collagen trimers

COL4A2 COL4A3

6.96e-0421392GO:0098644
GeneOntologyCellularComponentplasma membrane protein complex

TRAV8-6 TRAV8-2 TRAV5 C5 TRAV39 TRAV18

3.11e-03785396GO:0098797
GeneOntologyCellularComponentendoplasmic reticulum lumen

COL4A2 PCSK5 COL4A3 ERLEC1

3.32e-03332394GO:0005788
DomainC4

COL4A2 COL4A3

2.57e-056252SM00111
Domain-

COL4A2 COL4A3

2.57e-0562522.170.240.10
DomainCollagen_VI_NC

COL4A2 COL4A3

2.57e-056252IPR001442
DomainNC1_IV

COL4A2 COL4A3

2.57e-056252PS51403
Domain-

IGF2R ERLEC1

2.57e-0562522.70.130.10
DomainC4

COL4A2 COL4A3

2.57e-056252PF01413
DomainMan6P_isomerase_rcpt-bd_dom

IGF2R ERLEC1

4.79e-058252IPR009011
DomainCollagen

COL4A2 COL4A3

5.74e-0385252PF01391
DomainCollagen

COL4A2 COL4A3

5.74e-0385252IPR008160
DomainCTDL_fold

COL4A2 COL4A3

8.95e-03107252IPR016187
PathwayREACTOME_COMPLEMENT_CASCADE

IGHV3-48 C5 IGHV3-21 IGHV3-11 IGHV3-66

7.25e-0884195MM14653
PathwayREACTOME_CD22_MEDIATED_BCR_REGULATION

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.20e-0735194MM17219
PathwayREACTOME_CLASSICAL_ANTIBODY_MEDIATED_COMPLEMENT_ACTIVATION

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.88e-0739194MM17212
PathwayREACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

3.39e-0745194MM14912
PathwayREACTOME_FCGR_ACTIVATION

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

4.42e-0748194MM17214
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

6.62e-0753194MM15716
PathwayREACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

7.14e-0754194MM14655
PathwayREACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

8.28e-0756194MM14815
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

9.55e-0758194MM14914
PathwayREACTOME_FCERI_MEDIATED_MAPK_ACTIVATION

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.10e-0660194MM14913
PathwayREACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.10e-0660194MM14872
PathwayREACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.11e-05107194MM14915
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.43e-05114194MM14814
PathwayREACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.48e-05131194MM15717
PathwayREACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.79e-05135194MM14781
PathwayREACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

4.22e-05150194MM14889
PathwayREACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

5.16e-05158194MM14812
PathwayBIOCARTA_NPP1_PATHWAY

COL4A2 COL4A3

7.70e-0510192M22040
PathwayBIOCARTA_NPP1_PATHWAY

COL4A2 COL4A3

7.70e-0510192MM1560
PathwayBIOCARTA_VITCB_PATHWAY

COL4A2 COL4A3

9.40e-0511192M15422
PathwayBIOCARTA_VITCB_PATHWAY

COL4A2 COL4A3

1.13e-0412192MM1526
PathwayBIOCARTA_ACE2_PATHWAY

COL4A2 COL4A3

1.33e-0413192MM1347
PathwayBIOCARTA_ACE2_PATHWAY

COL4A2 COL4A3

1.33e-0413192M12950
PathwayBIOCARTA_PLATELETAPP_PATHWAY

COL4A2 COL4A3

1.55e-0414192MM1458
PathwayBIOCARTA_PLATELETAPP_PATHWAY

COL4A2 COL4A3

1.55e-0414192M6487
PathwayREACTOME_ANCHORING_FIBRIL_FORMATION

COL4A2 COL4A3

1.79e-0415192M27161
PathwayREACTOME_LAMININ_INTERACTIONS

COL4A2 COL4A3

1.79e-0415192MM14922
PathwayREACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS

COL4A2 COL4A3

2.60e-0418192M27164
PathwayREACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS

COL4A2 COL4A3

2.60e-0418192MM14882
PathwayREACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS

COL4A2 IGHV3-48 IGHV3-11

2.91e-0498193M27152
PathwayBIOCARTA_AMI_PATHWAY

COL4A2 COL4A3

3.22e-0420192M15394
PathwayREACTOME_NCAM1_INTERACTIONS

COL4A2 COL4A3

3.22e-0420192MM15061
PathwayBIOCARTA_INTRINSIC_PATHWAY

COL4A2 COL4A3

4.28e-0423192M15997
PathwayBIOCARTA_INTRINSIC_PATHWAY

COL4A2 COL4A3

4.28e-0423192MM1427
PathwayREACTOME_COMPLEMENT_CASCADE

IGHV3-48 C5 IGHV3-11

4.66e-04115193M19752
PathwayREACTOME_LAMININ_INTERACTIONS

COL4A2 COL4A3

7.32e-0430192M27216
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

COL4A2 COL4A3

8.33e-0432192MM14924
PathwayREACTOME_POTENTIAL_THERAPEUTICS_FOR_SARS

IGHV3-48 MTA1 IGHV3-11

1.09e-03154193M39007
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

COL4A2 COL4A3

1.18e-0338192MM14969
PathwayREACTOME_VESICLE_MEDIATED_TRANSPORT

IGHV3-48 IGF2R IGHV3-21 IGHV3-11 IGHV3-66

1.34e-03645195MM15232
PathwayREACTOME_COLLAGEN_CHAIN_TRIMERIZATION

COL4A2 COL4A3

1.37e-0341192MM15538
PathwayREACTOME_NCAM1_INTERACTIONS

COL4A2 COL4A3

1.43e-0342192M7169
PathwayREACTOME_INNATE_IMMUNE_SYSTEM

IGHV3-48 C5 IGF2R IGHV3-21 IGHV3-11 IGHV3-66

1.49e-03995196MM14661
PathwayREACTOME_COLLAGEN_CHAIN_TRIMERIZATION

COL4A2 COL4A3

1.57e-0344192M27812
PathwayREACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES

COL4A2 COL4A3

2.03e-0350192MM14796
PathwayREACTOME_COLLAGEN_DEGRADATION

COL4A2 COL4A3

2.28e-0353192MM14566
PathwayREACTOME_SIGNALING_BY_PDGF

COL4A2 COL4A3

2.63e-0357192MM14713
PathwayREACTOME_SIGNALING_BY_PDGF

COL4A2 COL4A3

2.72e-0358192M2049
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

COL4A2 COL4A3

2.81e-0359192M27218
PathwayREACTOME_CD22_MEDIATED_BCR_REGULATION

IGHV3-48 IGHV3-11

3.00e-0361192M27581
PathwayREACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES

COL4A2 COL4A3

3.00e-0361192M27103
PathwayREACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES

COL4A2 COL4A3

3.00e-0361192MM14637
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

COL4A2 COL4A3

3.20e-0363192M11187
PathwayREACTOME_COLLAGEN_DEGRADATION

COL4A2 COL4A3

3.30e-0364192M26953
PathwayREACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES

COL4A2 COL4A3

3.61e-0367192M26999
PathwayREACTOME_FCGR_ACTIVATION

IGHV3-48 IGHV3-11

3.83e-0369192M27108
PathwayREACTOME_SCAVENGING_OF_HEME_FROM_PLASMA

IGHV3-48 IGHV3-11

3.83e-0369192M27150
PathwayREACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS

IGHV3-48 IGHV3-11

4.05e-0371192M1078
PathwayREACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION

IGHV3-48 IGHV3-11

4.05e-0371192M27203
PathwayREACTOME_COLLAGEN_FORMATION

COL4A2 COL4A3

4.62e-0376192MM14573
PathwayREACTOME_ECM_PROTEOGLYCANS

COL4A2 COL4A3

4.62e-0376192M27219
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

COL4A2 COL4A3

4.62e-0376192MM14867
PathwayREACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

IGHV3-48 IGHV3-11

5.11e-0380192M6121
PathwayREACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS

IGHV3-48 IGHV3-11

5.36e-0382192M27110
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

COL4A2 COL4A3

5.75e-0385192M16441
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

IGHV3-48 IGHV3-11

5.88e-0386192M601
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

IGHV3-48 IGHV3-11

5.88e-0386192M27206
PathwayREACTOME_FCERI_MEDIATED_MAPK_ACTIVATION

IGHV3-48 IGHV3-11

6.01e-0387192M27205
PathwayREACTOME_HEMOSTASIS

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

6.35e-03571194MM14472
PathwayREACTOME_COLLAGEN_FORMATION

COL4A2 COL4A3

6.42e-0390192M631
PathwayREACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS

IGHV3-48 IGHV3-11

7.13e-0395192M29842
PathwayWP_SMALL_CELL_LUNG_CANCER

COL4A2 COL4A3

7.28e-0396192M39834
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

COL4A2 COL4A3

1.01e-02114192MM14571
PathwayREACTOME_PARASITE_INFECTION

IGHV3-48 IGHV3-11

1.05e-02116192M29843
PathwayREACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION

IGHV3-48 IGHV3-11

1.38e-02134192M29840
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.41e-02719194MM14540
PathwayREACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION

IGHV3-48 IGHV3-11

1.42e-02136192M27207
PathwayREACTOME_VESICLE_MEDIATED_TRANSPORT

COL4A2 IGHV3-48 IGF2R IGHV3-11

1.45e-02725194M27507
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

COL4A2 COL4A3

1.50e-02140192M587
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

IGHV3-48 IGHV3-11

1.56e-02143192M27107
Pubmed

IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes.

IGHV3-48 IGKV3D-7 TRAV5 IGHV3-21 IGHV3-11 TRAV18 IGHV3-66

2.86e-127739715608191
Pubmed

1.3 A X-ray structure of an antibody Fv fragment used for induced membrane-protein crystallization.

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.83e-091539412657787
Pubmed

Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

9.73e-09223942499654
Pubmed

STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion.

STAG3L2 STAG3L3 STAG3L1

1.30e-08539310698974
Pubmed

Molecular analysis of spontaneous somatic mutants.

IGHV3-48 IGHV3-21 IGHV3-11

1.30e-085393401950
Pubmed

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region.

IGHV3-48 IGHV3-21 IGHV3-11

1.05e-06183936788376
Pubmed

The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus.

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

3.36e-06913949841928
Pubmed

Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13.

COL4A2 COL4A3

3.67e-0633923025878
Pubmed

Collagen types in various layers of the human aorta and their changes with the atherosclerotic process.

COL4A2 COL4A3

3.67e-0633923089234
Pubmed

Higher-order immunoglobulin repertoire restrictions in CLL: the illustrative case of stereotyped subsets 2 and 169.

IGHV3-48 IGHV3-21

3.67e-06339233036024
Pubmed

Nature and the multiple functions of the 67-kD elastin-/laminin binding protein.

COL4A2 COL4A3

7.34e-0643927827955
Pubmed

The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA.

TRAV8-2 TRAV5 TRAV39 TRAV18

1.15e-051243948188290
Pubmed

In vitro interactions of oxidatively modified LDL with type I, II, III, IV, and V collagen, laminin, fibronectin, and poly-D-lysine.

COL4A2 COL4A3

1.22e-0553929409248
Pubmed

Insertional mutation of the collagen genes Col4a3 and Col4a4 in a mouse model of Alport syndrome.

COL4A2 COL4A3

1.83e-05639210534397
Pubmed

Abnormal basement membrane in the inner ear and the kidney of the Mpv17-/- mouse strain: ultrastructural and immunohistochemical investigations.

COL4A2 COL4A3

1.83e-05639216041630
Pubmed

Stimulation of extracellular matrix components in the normal brain by invading glioma cells.

COL4A2 COL4A3

1.83e-0563929506531
Pubmed

Angiogenesis and collagen type IV expression in different endothelial cell culture systems.

COL4A2 COL4A3

1.83e-05639223551189
Pubmed

HIV-1 gp160 protein-macrophage interactions modulate mesangial cell proliferation and matrix synthesis.

COL4A2 COL4A3

1.83e-0563927495302
Pubmed

Monoclonal antibody to human basement membrane collagen type IV.

COL4A2 COL4A3

1.83e-0563926811420
Pubmed

Localization of type IV collagen a 1 to a 6 chains in basement membrane during mouse molar germ development.

COL4A2 COL4A3

1.83e-05639211732842
Pubmed

Developmental distribution of collagen IV isoforms and relevance to ocular diseases.

COL4A2 COL4A3

1.83e-05639219275937
Pubmed

Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin.

COL4A2 COL4A3

1.83e-0563926988303
Pubmed

Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas.

COL4A2 COL4A3

1.83e-0563926389236
Pubmed

A tumor derived motility factor that stimulates cell migration on extracellular matrix.

COL4A2 COL4A3

1.83e-0563929673377
Pubmed

Extracellular matrix of the human optic nerve head.

COL4A2 COL4A3

1.83e-0563922426947
Pubmed

Collagen IV in the developing lens capsule.

COL4A2 COL4A3

1.83e-05639212225806
Pubmed

Corneal cell proteins and ocular surface pathology.

COL4A2 COL4A3

2.56e-05739210416788
Pubmed

Nidogen-1. Expression and ultrastructural localization during the onset of mesoderm formation in the early mouse embryo.

COL4A2 COL4A3

2.56e-05739210639489
Pubmed

Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development.

COL4A2 COL4A3

2.56e-0573927521231
Pubmed

Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M.

COL4A2 COL4A3

2.56e-05739211711546
Pubmed

Regulation of protease nexin-1 target protease specificity by collagen type IV.

COL4A2 COL4A3

2.56e-0573928006028
Pubmed

Hypoplastic basement membrane of the lens anlage in the inheritable lens aplastic mouse (lap mouse).

COL4A2 COL4A3

2.56e-05739210716744
Pubmed

Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface.

COL4A2 COL4A3

2.56e-0573921724753
Pubmed

Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth.

COL4A2 COL4A3

3.42e-05839210382266
Pubmed

Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling.

COL4A2 COL4A3

3.42e-05839211683410
Pubmed

Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II.

COL4A2 COL4A3

3.42e-0583923997552
Pubmed

Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium.

COL4A2 COL4A3

3.42e-05839229422532
Pubmed

Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons.

COL4A2 COL4A3

3.42e-05839210970885
Pubmed

Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV.

COL4A2 COL4A3

3.42e-0583921377218
Pubmed

Molecular properties of wild-type and mutant betaIG-H3 proteins.

COL4A2 COL4A3

3.42e-05839211867580
Pubmed

Developmental changes in seminiferous tubule extracellular matrix components of the mouse testis: alpha 3(IV) collagen chain expressed at the initiation of spermatogenesis.

COL4A2 COL4A3

4.39e-0593928562707
Pubmed

MMP-9 from TNF alpha-stimulated keratinocytes binds to cell membranes and type I collagen: a cause for extended matrix degradation in inflammation?

COL4A2 COL4A3

4.39e-0593929878537
Pubmed

Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.

COL4A2 COL4A3

4.39e-05939212101409
Pubmed

Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome.

COL4A2 COL4A3

4.39e-05939210880400
Pubmed

Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A.

COL4A2 COL4A3

4.39e-0593928995276
Pubmed

Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans.

COL4A2 COL4A3

5.48e-05103929136074
Pubmed

Distribution of fibronectin, type I collagen, type IV collagen, and laminin in the cardiac jelly of the mouse embryonic heart with retinoic acid-induced complete transposition of the great arteries.

COL4A2 COL4A3

5.48e-05103929415455
Pubmed

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

COL4A2 COL4A3

6.70e-051139217339318
Pubmed

Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development.

COL4A2 COL4A3

6.70e-051139214998921
Pubmed

Binding of mouse and human fibulin-2 to extracellular matrix ligands.

COL4A2 COL4A3

6.70e-05113927500359
Pubmed

Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3.

COL4A2 COL4A3

6.70e-05113929731539
Pubmed

Matrilin-2 interacts with itself and with other extracellular matrix proteins.

COL4A2 COL4A3

8.03e-051239212180907
Pubmed

Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice.

COL4A2 COL4A3

8.03e-051239216024816
Pubmed

Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice.

COL4A2 COL4A3

8.03e-05123928918877
Pubmed

Basement membrane fragility underlies embryonic lethality in fukutin-null mice.

COL4A2 COL4A3

8.03e-051239215837576
Pubmed

Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning.

COL4A2 COL4A3

8.03e-051239226794322
Pubmed

Basal lamina molecules are concentrated in myogenic regions of the mouse limb bud.

COL4A2 COL4A3

9.48e-05133929833687
Pubmed

Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors.

COL4A2 COL4A3

1.11e-041439212878203
Pubmed

Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.

COL4A2 COL4A3

1.27e-041539210625553
Pubmed

Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye.

COL4A2 COL4A3

1.27e-04153929264260
Pubmed

Inhibition of distal lung morphogenesis in Nkx2.1(-/-) embryos.

COL4A2 COL4A3

1.27e-041539210706142
Pubmed

Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.

COL4A2 COL4A3

1.46e-041639215878328
Pubmed

Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation.

COL4A2 COL4A3

1.85e-04183929160753
Pubmed

Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development.

COL4A2 COL4A3

2.07e-041939215689378
Pubmed

The Wilms tumor gene, Wt1, maintains testicular cord integrity by regulating the expression of Col4a1 and Col4a2.

COL4A2 COL4A3

2.54e-042139223325811
Pubmed

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.

COL4A2 COL4A3

2.54e-042139227856617
Pubmed

Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.

COL4A2 COL4A3

3.91e-042639224742657
Pubmed

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.

COL4A2 COL4A3

5.58e-043139222925884
Pubmed

Large-scale identification of genes implicated in kidney glomerulus development and function.

COL4A2 COL4A3

6.72e-043439216498405
Pubmed

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.

COL4A2 SLC6A15 B3GLCT IGF2R ERLEC1 SLC30A6

8.37e-04100739634597346
Pubmed

Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

MTA1 KIAA0825

8.40e-043839233283408
Pubmed

Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus.

IGHV3-48 IGHV3-11

8.84e-04393928490662
Pubmed

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

PCSK5 IGF2R

8.84e-043939219010793
Pubmed

Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.

COL4A2 COL4A3

9.30e-044039227068110
Cytoband14q11

TRAV8-6 TRAV8-2 TRAV5 TRAV39 TRAV18

9.69e-0813239514q11
CytobandEnsembl 112 genes in cytogenetic band chr14q11

TRAV8-6 TRAV8-2 TRAV5 TRAV39 TRAV18

9.03e-06332395chr14q11
Cytoband14q32.33

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

4.25e-0522839414q32.33
Cytoband7q11.23

STAG3L2 STAG3L3 STAG3L1

7.91e-05973937q11.23
CytobandEnsembl 112 genes in cytogenetic band chr14q32

IGHV3-48 MTA1 IGHV3-21 IGHV3-11 IGHV3-66

1.14e-04566395chr14q32
CytobandEnsembl 112 genes in cytogenetic band chr3p22

NKTR CMTM7 SLC22A14

5.20e-04184393chr3p22
CytobandEnsembl 112 genes in cytogenetic band chr7q11

STAG3L2 STAG3L3 STAG3L1

1.59e-03271393chr7q11
CytobandEnsembl 112 genes in cytogenetic band chr12q21

SLC6A15 PTPRQ

6.44e-03141392chr12q21
GeneFamilyT-cell receptor alpha locus at 14q11.2

TRAV8-6 TRAV8-2 TRAV5 TRAV39 TRAV18

2.14e-06117335371
GeneFamilyCD molecules|MRH domain containing

IGF2R ERLEC1

4.82e-0563321233
GeneFamilyImmunoglobulin heavy locus at 14q32.33

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

3.59e-04187334349
GeneFamilyCollagens

COL4A2 COL4A3

3.18e-0346332490
CoexpressionXU_CREBBP_TARGETS_DN

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.17e-0656374MM642
CoexpressionYAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.29e-05102374MM872
CoexpressionRASHI_RESPONSE_TO_IONIZING_RADIATION_6

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

3.57e-05132374MM996
CoexpressionAtlasAravindRamakr_StemCell-hypoxiaGrown_fromBlastocyst-derived-humanEmbryonicStemCells_top-relative-expression-ranked_500_k-means-cluster#2

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

8.96e-05163314Arv_SC-hpx_blastocyst_500_K2
CoexpressionAtlasAravindRamakr_StemCell-H9hpx_top-relative-expression-ranked_500_k-means-cluster#3

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.18e-04175314Arv_SC-H9hpx_500_K3
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-48 IGHV3-21 IGHV3-11 IGLV9-49 ERLEC1 IGHV3-66

1.26e-0818439615f2c10101ccc8ed059520fc082ee42593dff269
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-48 IGHV3-21 IGHV3-11 IGLV9-49 ERLEC1 IGHV3-66

1.26e-08184396a90a58d9e319afa1cd572e4c2f516fadc42f56e5
ToppCellhealthy_donor-Lymphocytic-Plasma_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11 ERLEC1 IGHV3-66

1.43e-08188396bd53b0371154cff680226897b61c9809a239d1b6
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A3 IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11 IGHV3-66

1.72e-08194396a4a70369541876e1192df8828b63e3d1746ae3d9
ToppCellmetastatic_Lymph_Node-B_lymphocytes-Plasma_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

IGHV3-48 IGHV3-21 IGHV3-11 IGLV9-49 ERLEC1

1.54e-071423955ba3a33c2ee20be8baaed97536ca6e9d1de6752f
ToppCell367C-Lymphocytic-Plasma_cell-|367C / Donor, Lineage, Cell class and subclass (all cells)

IGHV3-48 IGHV3-21 IGHV3-11 IGLV9-49 IGHV3-66

3.45e-07167395f2185eb72f0137136f6d71af2a70168fded6c940
ToppCell367C-Lymphocytic-Plasma_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

IGHV3-48 IGHV3-21 IGHV3-11 IGLV9-49 IGHV3-66

3.45e-071673955e768cf24699893e05d1bcb1c92dba2336943a64
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-SELL+_CD8_T|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRAV8-2 TRAV5 TRAV39 TRAV18 HELB

3.99e-0717239510090b4b40f0f6f07a514e86811cadeecdf21670
ToppCell3'_v3-bone_marrow-Lymphocytic_B_plasma-Plasma_cells|bone_marrow / Manually curated celltypes from each tissue

IGHV3-48 IGHV3-21 IGHV3-11 ERLEC1 IGHV3-66

4.35e-0717539551301f3f44d3e88397f367cedd1e2abaa2be4c6f
ToppCell(2)_Plasma_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

IGHV3-48 IGHV3-21 IGLV9-49 ERLEC1 IGHV3-66

4.60e-07177395ed3c936bb69f9bc7291b4f6cde1d204078117c48
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-21 IGHV3-11 IGLV9-49 ERLEC1 IGHV3-66

5.00e-07180395cea079bc02e08c46600eed05ab9924ec90e1e3d3
ToppCellcellseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

IGHV3-48 IGHV3-21 IGHV3-11 IGLV9-49 IGHV3-66

5.42e-071833955ab4aa0304b832f98fff89b6c24ad5b7dd014c11
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IGHV3-48 IGHV3-21 IGHV3-11 IGLV9-49 ERLEC1

5.72e-071853950fff2608f507e019ebb69c27e58fd5be3b049bef
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IGHV3-48 IGHV3-21 IGHV3-11 IGLV9-49 ERLEC1

5.72e-0718539579edc1eeb7b5b9123961ac3ecf398ee68d9dddb9
ToppCellhealthy_donor-Lymphocytic-Plasma_cell-IgA_Plasmablast|healthy_donor / Disease condition, Lineage, Cell class and subclass

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11 ERLEC1

5.88e-07186395e2c050ba02e1f84f0b7258dc92e7ff6ab349ff67
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11 IGHV3-66

7.05e-0719339534f6c13884fdf7f8a87f942fcb36a58cfac3f65d
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_plasma|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11 IGHV3-66

7.05e-07193395282b47dae6043eabb1e13d41d91c07b5ec21cd65
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11 IGHV3-66

7.23e-071943956ef4aeb8d8e35e4df58ff2a8256caa2113291de9
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11 IGHV3-66

7.42e-0719539513f4ee21568fd747608412d33559d10561dbb3c8
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-48 IGHV3-21 IGHV3-11 IGLV9-49 IGHV3-66

7.42e-07195395f3f7f1a77a1edd2b50a8211c76fe289738eb04cf
ToppCellCOVID_vent-Lymphocytic-Plasma_cell-IgM_Plasmablast|COVID_vent / Disease condition, Lineage, Cell class and subclass

IGHV3-48 IGHV3-21 IGHV3-11 ERLEC1 IGHV3-66

7.61e-07196395026a06d8d2089806823e6f6453d3ede84ae93bc6
ToppCellBiopsy_IPF-Immune-Plasma_cells|Biopsy_IPF / Sample group, Lineage and Cell type

IGHV3-48 IGHV3-21 IGHV3-11 IGLV9-49 IGHV3-66

7.61e-07196395a1b6a8000b86efcb07843998aa3a49bb1f54bcda
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell-IgA_Plasmablast|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11 ERLEC1

7.80e-07197395fdbf4eb9fa5aefb4ffb307494fe4774bf5e0aaeb
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IGHV3-48 IGHV3-21 IGHV3-11 ERLEC1 IGHV3-66

7.80e-071973951e63879633f20646e44873ae6b662f6faf4806fd
ToppCellhealthy_donor-Lymphocytic-Plasma_cell-IgG_Plasmablast|healthy_donor / Disease condition, Lineage, Cell class and subclass

IGKV3D-7 IGHV3-21 IGHV3-11 ERLEC1

9.39e-06152394a2ba2d95ac9010e1a62db34dcad10d004f8a90cc
ToppCell368C-Lymphocytic-Plasma_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.21e-05162394f945688815229c8386cbcbf46deee7df316fa8d3
ToppCell368C-Lymphocytic-Plasma_cell-|368C / Donor, Lineage, Cell class and subclass (all cells)

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.21e-05162394c21a54310b239d999bbc9d8fb5e8fda16e0bc336
ToppCellBAL-Mild-Lymphocyte-B|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

COL4A3 IGHV3-48 IGHV3-21 IGHV3-11

1.43e-05169394307571e57c3bfdf15f0fe1a8b36585e8e4f8a207
ToppCellControl-Lymphoid-B_Plasma|World / Disease state, Lineage and Cell class

IGHV3-48 IGKV3D-7 IGHV3-11 IGLV9-49

1.46e-05170394fb05f49b7113470995b3c16683c54dc1a660b73a
ToppCell10x5'-Lung-Lymphocytic_B-Memory_B_cells|Lung / Manually curated celltypes from each tissue

COL4A3 IGHV3-48 IGHV3-21 IGLV9-49

1.53e-051723942cb2dc7cfd6db5a98a393b1a84c23abf3d692a53
ToppCellControl-Lymphoid-B_Plasma|Control / Disease state, Lineage and Cell class

IGHV3-48 IGKV3D-7 IGHV3-11 IGLV9-49

1.53e-0517239461e33836b8cb0f347f3e699eb587a37073b6fa4c
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-48 IGHV3-21 IGLV9-49 ERLEC1

1.56e-051733940ca2169a275404118038c0489a48062879488765
ToppCellmetastatic_Brain-B_lymphocytes-MALT_B_cells|metastatic_Brain / Location, Cell class and cell subclass

IGHV3-48 IGHV3-21 IGLV9-49 IGHV3-66

1.67e-0517639450e207403d48ce1b55a78897adb5519a2430a626
ToppCellControl-Lymphoid_P|Control / Disease group, lineage and cell class

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11

1.67e-05176394d895a6b295cd649273ff80ad7785a3e0ae4c728a
ToppCellControl-Lymphoid_P-Plasmablast|Control / Disease group, lineage and cell class

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11

1.67e-051763944b4416f342b732d2cc60133838728880326257d8
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IGHV3-48 IGHV3-21 IGHV3-11 ERLEC1

1.71e-05177394c2b0fb5921eea24d248d6e6ccb57c29b0832602c
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11

1.71e-051773944c434a7b7cc54cf4dac996bbc3f5124d9ef9a9cd
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11

1.71e-05177394fc40918825b7e1eb6861df59dfca944778a64b98
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IGHV3-48 IGHV3-21 IGHV3-11 ERLEC1

1.71e-05177394111fb0707ff37ca631d85bb5a09e067ffe568eb8
ToppCellVE-plasma|VE / Condition, Cell_class and T cell subcluster

IGHV3-48 IGHV3-21 IGHV3-11 IGLV9-49

1.71e-051773940c1cc0834de55717cb4f69d020339060ce2c9a03
ToppCellVE-plasma-|VE / Condition, Cell_class and T cell subcluster

IGHV3-48 IGHV3-21 IGHV3-11 IGLV9-49

1.71e-051773943a3c94cf30012e2aa266bc4d7fe772e45fa90f6d
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11

1.71e-05177394d746122bf8d208c3aa4d156e8c12d0a0e555c6e5
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-B_cells-Immature_B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGHV3-48 IGHV3-21 IGHV3-11 ZDHHC23

1.75e-051783942e51c1596022b7047994ee13c18375bad19a54a5
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells-Pre-B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGHV3-21 IGHV3-11 IGLV9-49 CMTM7

1.75e-0517839434ef4d36ddfb1cdeaaaf5d952e1ad6dc2785ce1e
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.75e-05178394107dae8b00c4257697a63700e72bb434cdb8406f
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11

1.79e-05179394837ed81f18257f444eaeadc4fac89deedd4e3061
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11

1.79e-05179394494febe77c6d4e6a2c6f0928bbf4c84b0301f188
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-11

1.79e-05179394b6ee4f41d8fb5f047b7bdd8489dda0a89fc6d43f
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-48 IGKV3D-7 IGHV3-21 IGHV3-66

1.87e-05181394e47664a264a2c37390d1668ce04eef2e0172f4cb
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-48 IGHV3-21 IGLV9-49 ERLEC1

1.91e-051823941bf2e4fd6222b41a7d08df6dcc500c9401db8c18
ToppCellMild_COVID-19-B_cell|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.95e-05183394dea119e2988e954475f557f0bbe12556a83e81a4
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.99e-051843943f8a359e40bebe58545f708682e5e5d1b70cf5cb
ToppCell367C-Lymphocytic-Plasma_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IGHV3-48 IGHV3-11 IGLV9-49 ERLEC1

1.99e-05184394fc708a5c8a7b19fab973c72dc4383a7d30f8b59a
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

1.99e-0518439464bede8db709fd32f40c03265b96f0b12155bb8a
ToppCell367C-Lymphocytic-Plasma_cell-|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IGHV3-48 IGHV3-11 IGLV9-49 ERLEC1

1.99e-0518439414a5288d861260f63fbe0cbea3569cf643e7597e
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-B_cells-Pre-B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGHV3-48 IGHV3-21 IGLV9-49 CMTM7

2.03e-051853940fa7970709dc957dea95fabbd83263a0335babd5
ToppCellBAL-Mild-Lymphocyte-B-B_cell|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.03e-05185394609080adb2cfb105bb7b8efb617553833299f371
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.03e-0518539408bc817908076734d66f2805cb954141f2cc5a18
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.03e-051853941704a12153a9b107bf03ecccd1a036cf61334d7a
ToppCellAnterior_Cingulate_gyrus_(CgG)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 STAG3L2 STAG3L3 STAG3L1

2.08e-0518639432af3f211f9ad5d5c6b86b83325cfbf2f8466b56
ToppCellMild_COVID-19-B_cell-B_cell|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.08e-05186394855a5a00ba2aa1b5c63b8db56d026ddecc546050
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-21 IGHV3-11 IGLV9-49 IGHV3-66

2.17e-051883946844cebca177fdf38b21a40d606230a033717a3a
ToppCellcellseq2-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

IGHV3-48 IGHV3-21 IGLV9-49 ERLEC1

2.17e-0518839433360f1c30315d9772731c9067834dc059172b79
ToppCellPBMC-Mild-Lymphocyte-B-Plasmablast-Plasmablast-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IGHV3-48 IGHV3-21 IGHV3-11 ERLEC1

2.21e-05189394c296660061b46e3abae1e7cf29df20274e5a8add
ToppCellPBMC-Mild-Lymphocyte-B-Plasmablast-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGHV3-48 IGHV3-21 IGHV3-11 ERLEC1

2.21e-0518939473ee4cfb1057832f700be59b6917dedde3e89880
ToppCellPBMC-Mild-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGHV3-48 IGHV3-21 IGHV3-11 ERLEC1

2.21e-05189394a1bda6ed5c52a5d33d229018cb5982cae6305533
ToppCellPBMC-Mild-Lymphocyte-B-Plasmablast-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IGHV3-48 IGHV3-21 IGHV3-11 ERLEC1

2.21e-0518939431594cc59eb1c5b01407dfd72b1487ecca8bf5ec
ToppCellPBMC-Mild-Lymphocyte-B-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGHV3-48 IGHV3-21 IGHV3-11 ERLEC1

2.21e-05189394f2daf4889ef98bbefe3e44832618ac102a75b4d9
ToppCellPBMC-Mild-Lymphocyte-B-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGHV3-48 IGHV3-21 IGHV3-11 ERLEC1

2.21e-051893949de17ade3cc3e9cd1394338bd048fb1ce64ac50f
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-B_lymphocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

COL4A3 IGHV3-48 IGHV3-21 ERLEC1

2.26e-05190394a21d0c574abf21e7cb865a21a48f29c92d055fbe
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.26e-0519039479ee6d10dfbb775da149a1104da5823cf63bbb46
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.26e-0519039418762ce78ed0b206ade19e1c8ff76a2647489f68
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.35e-05192394ca4d8e540d9e6fa47ecf97648cbd5abfc7ab7f85
ToppCellCOVID-19-Lymphoid-Plasma,_B_cells|COVID-19 / Condition, Lineage and Cell class

COL4A3 IGHV3-48 IGHV3-11 IGHV3-66

2.40e-05193394bffd97a73365e1dd23ff3b0320b4860f04ec091a
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell-IgM_Plasmablast|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IGHV3-48 IGHV3-21 IGHV3-11 ERLEC1

2.40e-051933947b4b0271e4fbece703876acb053ae236afb7cdba
ToppCellBiopsy_Other_PF-Immune-Plasma_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

IGHV3-48 IGHV3-21 IGLV9-49 IGHV3-66

2.50e-05195394d0305c6a68c9e361507b04db94f86873085d49b3
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.50e-051953942d18f08f33f3b261c77b8adf87d1a184cc6d7400
ToppCellBronchial-10x5prime-Immune_Lymphocytic-T-T_CD4-CD4_TRM/EMRA|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TRAV8-6 TRAV8-2 TRAV39 IGLV9-49

2.50e-051953946b6c4a0c713f32c757bd303aa84ec7dc3d825cc8
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_plasma|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.55e-05196394c38e7f533c619afe008de0e99042f7180c2da918
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A3 IGHV3-48 IGHV3-21 IGHV3-11

2.55e-05196394e9fe5090452ffdde4bb81b62d57037d823281d00
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.55e-05196394fec21383435779bf4c632decd3d29c6ca7baebfb
ToppCellCOVID_vent-Lymphocytic-Plasma_cell-IgA_Plasmablast|COVID_vent / Disease condition, Lineage, Cell class and subclass

IGHV3-48 IGKV3D-7 IGHV3-21 ERLEC1

2.60e-0519739499fe44ef42c65d24fe64947fd5bf6d91b9a4b2c3
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A3 IGHV3-48 IGHV3-21 IGHV3-11

2.60e-0519739488b29d205237f07a9a26cc15a1cf4ed4816a4c4b
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A3 IGHV3-48 IGHV3-21 IGHV3-66

2.60e-051973940e56255862fed099e771ebd2529393dc5a3641ba
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.60e-051973942662138671262b30508c5759038bcdcfe6551696
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_cell-B_mature|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A3 IGHV3-48 IGHV3-21 IGHV3-66

2.60e-05197394da175e66d0a743a1b91d46f224b5ff1d37aa5410
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-48 IGHV3-21 IGHV3-11 IGHV3-66

2.60e-051973949fe1b757f76c2d43d39aa9ac500eaba98723985c
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell-IgG_Plasmablast|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IGHV3-48 IGHV3-21 ERLEC1 IGHV3-66

2.60e-05197394b754fad4f3caae6de95df901fd96ea8697fe41b1
ToppCellControl-Control-Lymphocyte-B-Plasmablast|Control / Disease, condition lineage and cell class

IGHV3-48 IGHV3-21 IGHV3-11 ERLEC1

2.71e-05199394c11aa8bca3723a886e7082ae48bb922dd8396be4
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_cell-B_naive|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-48 IGHV3-21 IGHV3-11 IGLV9-49

2.71e-051993948e02d3a066e79e0f2024a10738e0ea070513ef19
ToppCell10x5'v1-week_17-19-Lymphocytic_T-T_NK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TRAV8-6 TRAV8-2 TRAV5 TRAV18

2.76e-05200394b7ab3f644e6002635771dccaa192a111b4e0ed5b
ToppCell10x5'v1-week_17-19-Lymphocytic_T|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TRAV8-6 TRAV8-2 TRAV5 TRAV18

2.76e-052003942e01a35caeff5967a8b873c5122500d068dcf54c
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_B1|TCGA-Thymus / Sample_Type by Project: Shred V9

TRAV8-6 TRAV8-2 TRAV18

2.18e-041343936744851df56efb24aa92631dae19b687f149ae42
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_B1-4|TCGA-Thymus / Sample_Type by Project: Shred V9

TRAV8-2 TRAV5 TRAV18

2.48e-0414039321e5f55a98b819d3638ec971d5029b2fcbd1ebc7
ToppCell10x5'-blood-Lymphocytic_B_plasma-Plasma_cells|blood / Manually curated celltypes from each tissue

IGHV3-48 IGHV3-11 ERLEC1

2.86e-0414739358089378fac1743ce99dc4f1bd7b5253a927f050
ToppCell10x5'-blood-Lymphocytic_B_plasma|blood / Manually curated celltypes from each tissue

IGHV3-48 IGHV3-11 ERLEC1

3.04e-041503936bab0a8bf78ed7de9e1b67ede7496488f80f4863
ToppCellAT1-AT2_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

COL4A2 COL4A3 C5

3.35e-04155393010e45ef4b505bf419ea41e4d1619521d1c78319
ToppCell10x5'-Lung-Lymphocytic_B-ABC_aged-B_memory|Lung / Manually curated celltypes from each tissue

COL4A3 IGHV3-11 IGHV3-66

3.60e-04159393d3202ddc291b8686dbe67690df13c7daffec2199
ToppCellwk_20-22-Hematologic_Lymphocytic-T_&_ILC-T_entry|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PCSK5 TRAV8-2 TRAV18

3.81e-04162393a27750117e7f16a0bd07cc5f58a56becb39e800b
ToppCell3'_v3-blood-Lymphocytic_B_plasma-Plasma_cells|blood / Manually curated celltypes from each tissue

COL4A3 IGHV3-48 ERLEC1

4.02e-041653931c0c24fe252b761cf879b83562e23c02f0b6489f
DrugBrompheniramine maleate [980-71-2]; Down 200; 9.2uM; PC3; HT_HG-U133A

COL4A3 HMGXB3 MTA1 SLC22A14 GRAMD4

4.05e-061992854013_DN
Diseaseglucose metabolism decline measurement

PCSK5 COL4A3

3.83e-059312EFO_0009392
Diseasetumor necrosis factor ligand superfamily member 11 measurement

IGHV3-21 IGHV3-11

8.27e-0513312EFO_0010617
Diseaseatrophic macular degeneration, age-related macular degeneration, wet macular degeneration

COL4A3 B3GLCT

1.82e-0360312EFO_0001365, EFO_0004683, EFO_1001492
Diseasenon-lobar intracerebral hemorrhage

COL4A2 SLC6A15

2.00e-0363312EFO_0010178
DiseaseLung diseases

PCSK5 IGF2R

3.05e-0378312C0024115
DiseaseParkinson Disease

MTA1 IGF2R

3.61e-0385312C0030567
Diseaseage at menopause

SPPL3 GPR45 HELB

3.86e-03302313EFO_0004704

Protein segments in the cluster

PeptideGeneStartEntry
INCTYTDSSSTYLYW

TRAV5

41

A0A0B4J249
SSCSYRIESYWTYEV

ERLEC1

111

Q96DZ1
WESQASLIEYYSDYT

B3GLCT

291

Q6Y288
TCNYYSNSYSFWLAS

COL4A3

1621

Q01955
FSNCSYAQYWDSTIS

ADAM20

376

O43506
SDWYSVYTSAIAFTV

GRAMD4

226

Q6IC98
YYASRNDKSYWLSTT

COL4A2

1556

P08572
WVSVIYSCGSTYYAD

IGHV3-66

66

A0A0C4DH42
SFGFYSSIYCSTWLL

FFAR2

86

O15552
WVSYISSSSSYTNYA

IGHV3-11

66

P01762
CFEWLTNYNYSTSES

KIAA0825

71

Q8IV33
CRASQSVSSSYLSWY

IGKV3D-7

46

A0A0C4DH55
TSWSNYYESPSTQCL

HMGXB3

736

Q12766
WVSYISSSGSTIYYA

IGHV3-48

66

P01763
WYLEECSSTLATTYS

PCSK5

346

Q92824
CTLSSGYSNYKVDWY

IGLV9-49

41

A0A0B4J1Y8
SYAYTTAEVVYSWTL

GABRA3

211

P34903
WVSSISSSSSYIYYA

IGHV3-21

66

A0A0B4J1V1
SFYATSTCVLWLSYL

GPR45

301

Q9Y5Y3
TIFSYYTFWLTASTS

PTPRQ

1061

Q9UMZ3
AYSSLSQSYLYIDWT

C5

456

P01031
CVWFTVSYTYFTLSL

SLC22A14

386

Q9Y267
YTLCQVNYSFYSWTQ

HELB

556

Q8NG08
DNSTYNFRWYTSYAC

IGF2R

746

P11717
ECEQSSATTYYWYRE

SLC6A15

196

Q9H2J7
SRSWSYNGYYSDLST

NKTR

406

P30414
CWMQSYSTSFLTDSY

STAG3L1

31

P0CL83
RACESCYTTQSYQWY

MTA1

391

Q13330
SLWTNYSAYSYFEVV

CMTM7

66

Q96FZ5
RCNYSSSYSPSLFWY

TRAV8-2

41

A0A0B4J237
YSWAYSLVDSSQVST

SPPL3

6

Q8TCT6
RCNYSSSVSVYLFWY

TRAV8-6

41

A0A0B4J262
CWMQSYSTSFLTDSY

STAG3L2

31

P0CL84
NCTYQSSYSTFLFWY

TRAV18

41

A0A075B6X5
YSSALSFTCVWYSVI

ZDHHC23

346

Q8IYP9
WTSFLSAASTAIYVY

TM9SF3

516

Q9HD45
WCSSTNSIALTAYTY

SLC30A6

51

Q6NXT4
CWMQSYSTSFLTDSY

STAG3L3

31

P0CL85
CNYSTTSDRLYWYRQ

TRAV39

41

A0A0B4J263